JP3455553B2 - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JP3455553B2 JP3455553B2 JP22772992A JP22772992A JP3455553B2 JP 3455553 B2 JP3455553 B2 JP 3455553B2 JP 22772992 A JP22772992 A JP 22772992A JP 22772992 A JP22772992 A JP 22772992A JP 3455553 B2 JP3455553 B2 JP 3455553B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- retinol
- external preparation
- present
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Cosmetics (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明はレチノールの安定性を著
しく向上させた皮膚外用剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin in which retinol stability is remarkably improved.
【０００２】[0002]
【従来の技術】レチノールは皮膚角化症等の予防、治療
や、皮膚老化の防止、回復に有効な成分であることが知
られている。2. Description of the Related Art Retinol is known to be an effective component for the prevention and treatment of cutaneous keratoses and the like, and the prevention and restoration of skin aging.
【０００３】しかしながらレチノールは構造的に極めて
不安定であり、光、空気、熱、金属イオン等により容易
に種々の異性化、分解、重合等を起こすため、安定に皮
膚外用剤に配合することが困難であった。安定化を目的
として脂肪酸エステル化などの手法が試みられている
が、エステル化は安定化には効果があるものの皮膚への
作用という面ではレチノール自身よりはるかに劣ってし
まう。However, retinol is structurally extremely unstable and easily undergoes various isomerizations, decompositions, polymerizations and the like due to light, air, heat, metal ions, etc., so that it can be stably compounded in an external preparation for skin. It was difficult. Although methods such as fatty acid esterification have been attempted for the purpose of stabilization, esterification is effective for stabilization but is far inferior to retinol itself in terms of action on the skin.
【０００４】[0004]
【発明が解決しようとする課題】本発明者らは係る事情
に鑑み鋭意研究の結果、レチノールとともに、乳酸塩の
一種または二種以上を含有させればレチノールの安定性
が著しく向上することを見出し、本発明を完成するに至
った。DISCLOSURE OF INVENTION Problems to be Solved by the Invention As a result of intensive studies conducted by the present inventors in view of such circumstances, the stability of retinol was remarkably improved by containing retinol together with one or more lactate salts. The present invention has been completed and the present invention has been completed.
【０００５】[0005]
【課題を解決するための手段】すなわち本発明の要旨
は、０．０００１〜１重量％のレチノールとともに、
０．００１〜１重量％の乳酸塩の一種または二種以上を
含有し、レチノールを安定配合したことを特徴とする皮
膚外用剤に存在する。That is, the gist of the present invention is to provide 0.0001 to 1% by weight of retinol,
It exists in an external preparation for skin characterized by containing 0.001 to 1% by weight of one or more kinds of lactate and stably blending retinol.
【０００６】以下、本発明の構成について詳述する。The structure of the present invention will be described in detail below.
【０００７】本発明にもちいられるレチノールは通称ビ
タミンＡと呼ばれ、末端が水酸基であるレチノール自身
を示し、その脂肪酸エステルは含まない。ａｌｌ−トラ
ンス型または１３−シス型であることが望ましく、それ
らの混合物であっても構わない。The retinol used in the present invention is commonly called vitamin A, which means retinol itself having a hydroxyl group at the terminal, and does not contain its fatty acid ester. All-trans type or 13-cis type is desirable, and a mixture thereof may be used.
【０００８】本発明に従って皮膚外用剤に含有される量
としては特に制限はないが、レチノールとしての肌への
効果を考えると０．０００１重量％以上であり、レチノ
ールの効果を強く訴求するためには好ましくは０．００
１重量％以上である。上限は皮膚外用剤としての性質上
好ましくは１重量％である。The amount contained in the external preparation for skin according to the present invention is not particularly limited, but considering the effect on the skin as retinol, it is 0.0001% by weight or more, and in order to strongly appeal the effect of retinol. Is preferably 0.00
It is 1% by weight or more. The upper limit is preferably 1% by weight in view of the property as an external preparation for skin.
【０００９】また本発明の効果を発揮する目的で皮膚外
用剤に含有させられる乳酸塩としては、ナトリウム、カ
リウムなどの無機アルカリ塩、エタノールアミン、塩基
性アミノ酸などの有機アルカリ塩等で、モノ塩、ジ塩、
トリ塩が有名である。As the lactate contained in the external preparation for skin for the purpose of exerting the effect of the present invention, inorganic alkali salts such as sodium and potassium, organic alkali salts such as ethanolamine and basic amino acid, and mono-salts are used. , Di-salt,
Tori salt is famous.
【００１０】これらを一種または二種以上含有させる
が、本発明の効果を発揮する目的で含有せしめる量とし
ては０．００１重量％以上が必要であり、過剰に含有さ
せても本発明の効果を阻害するものではない。しかしな
がら著しく過剰に含有させた場合、皮膚外用剤としての
品質を損ねることがあるので注意が必要である。好まし
くは１重量％以下である。One kind or two or more kinds of these are contained, but the amount to be contained for the purpose of exerting the effect of the present invention is 0.001% by weight or more, and the effect of the present invention can be obtained even if it is contained in excess. It does not hinder. However, it should be noted that the content as a skin external preparation may be impaired if the content is excessively excessive. It is preferably 1% by weight or less.
【００１１】本発明においてレチノールとヒドロキシカ
ルボン酸塩を含有する皮膚外用剤基剤としては通常の皮
膚外用剤基剤ならばいずれのものも利用できる。すなわ
ち、液状、ゲル状、ペースト状、クリーム状、あるいは
粉末状、固状などのもので、皮膚外用剤を修飾する成分
として保湿剤、油分、界面活性剤、増粘剤、金属封鎖
剤、その他の紫外線吸収剤、薬剤、色素、香料などが併
用できることは言うまでもない。In the present invention, as the skin external preparation base containing retinol and hydroxycarboxylic acid salt, any ordinary skin external preparation base can be used. That is, liquid, gel, paste, cream, powder, solid or the like, as a component for modifying the skin external preparation, a moisturizer, an oil, a surfactant, a thickener, a sequestering agent, etc. It goes without saying that the ultraviolet absorbers, drugs, dyes, fragrances, etc. can be used in combination.
【００１２】[0012]
【実施例】次に本発明をより多くの実施例で詳述するが
本発明はこれにより限定されるものではない。EXAMPLES The present invention will now be described in more detail with reference to more examples, but the present invention is not limited thereto.
【００１３】[0013]
【表１】 [Table 1]
【００１４】実施例１、２では比較例に比べレチノール
の安定性が向上しているが、これは本発明に係る効果で
ある。The stability of retinol was improved in Examples 1 and 2 as compared with Comparative Example, which is an effect according to the present invention.
【００１５】レチノールの定量方法
エタノールを溶媒として用いた３２５ｎｍでの吸光度測
定法により定量を実施した。なお計算にあたっては極大
吸収３２５ｎｍ Ｅ（１％，１ｃｍ）＝１８３５とし
た。本発明に係る効果である。 Quantitative Method of Retinol Quantitative analysis was carried out by an absorbance measuring method at 325 nm using ethanol as a solvent. In the calculation, the maximum absorption was 325 nm E (1%, 1 cm) = 1835. This is the effect according to the present invention.
【００１６】[0016]
【００１７】実施例３ 美容エッセンス （重量％） カルボキシビニルポリマー ０．４ グリセリン ５ プロピレングリコール ５ 乳酸ナトリウム ０．０５ トリエタノールアミン ３．８ ＰＯＥ（６０）硬化ヒマシ油 ０．５ レチノール ０．１ スクワラン １ α−トコフェロール ０．０５ メチルパラベン ０．２ エチルアルコール ６ 精製水 全体を１００とする量 Example 3 Beauty Essence (wt%) Carboxyvinyl Polymer 0.4 Glycerin 5 Propylene Glycol 5 Sodium Lactate 0.05 Triethanolamine 3.8 POE (60) Hydrogenated Castor Oil 0.5 Retinol 0.1 Squalane 1 α-Tocopherol 0.05 Methylparaben 0.2 Ethyl alcohol 6 Purified water 100
【００１８】[0018]
【００１９】[0019]
【００２０】実施例４ ナイトクリーム （重量％） スクワラン １５ ２−エチルヘキサン酸トリグリセリド ５ ワセリン ５ ブチルパラベン ０．２ ジグリセリンジイソステアレート ２ ＰＥＧ４００ジイソステアレート ０．５ レチノール ０．１ グリセリン １０ クエン酸三ナトリウム ０．３ 乳酸ナトリウム ０．１ 乳酸 ０．１ 精製水 全体を１００とする量 Example 4 Night Cream (wt%) Squalane 15 2-Ethylhexanoic Acid Triglyceride 5 Vaseline 5 Butylparaben 0.2 Diglycerin Diisostearate 2 PEG400 Diisostearate 0.5 Retinol 0.1 Glycerin 10 Quen Trisodium acid 0.3 Sodium lactate 0.1 Lactic acid 0.1 Purified water 100
【００２１】実施例３〜４の皮膚外用剤は日常的な使用
においてレチノールの安定性に優れたものであった。The external preparations for skin of Examples 3 to 4 were excellent in retinol stability in daily use.
【００２２】[0022]
【発明の効果】本発明の皮膚外用剤においては乳酸塩を
含有することによりレチノールの安定性を著しく向上さ
せることができる。The external preparation for skin of the present invention can remarkably improve the stability of retinol by containing lactate .
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 昭62−419（ＪＰ，Ａ) 特開 平２−273613（ＪＰ，Ａ) 特公 昭36−17850（ＪＰ，Ｂ１) 特公 昭35−16497（ＪＰ，Ｂ１) 特表 平６−500079（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 ─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-62-419 (JP, A) JP-A-2-273613 (JP, A) JP-B 36-17850 (JP, B1) JP-B 35- 16497 (JP, B1) Special table HEI 6-500079 (JP, A) (58) Fields investigated (Int.Cl. 7 , DB name) A61K 7/00
Claims (2)
ともに、０．００１〜１重量％の乳酸塩の一種または二
種以上を含有し、レチノールを安定配合したことを特徴
とする皮膚外用剤。1. An external preparation for skin comprising 0.0001 to 1% by weight of retinol and 0.001 to 1% by weight of one or more kinds of lactate , and a stable blend of retinol.
ともに、０．００１〜１重量％の乳酸塩の一種または二
種以上を配合することを特徴とする皮膚外用剤中のレチ
ノールの安定化方法。2. A method for stabilizing retinol in an external preparation for skin, comprising blending 0.0001 to 1% by weight of retinol with 0.001 to 1% by weight of one or more lactate salts. .
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22772992A JP3455553B2 (en) | 1992-07-13 | 1992-07-13 | External preparation for skin |
| ES93914997T ES2221921T3 (en) | 1992-07-13 | 1993-07-13 | COMPOSITION FOR DERMATOLOGICAL PREPARATION. |
| DE69333526T DE69333526T2 (en) | 1992-07-13 | 1993-07-13 | DERMATOLOGICAL COMPOSITION |
| US08/204,286 US5484816A (en) | 1992-07-13 | 1993-07-13 | External skin treatment composition |
| PCT/JP1993/000969 WO1994001074A1 (en) | 1992-07-13 | 1993-07-13 | Composition for dermatologic preparation |
| DE1993634151 DE69334151T2 (en) | 1992-07-13 | 1993-07-13 | Retinol-containing, stabilized skin care product for external use |
| ES04000012T ES2289370T3 (en) | 1992-07-13 | 1993-07-13 | STABILIZED COMPOSITION FOR EXTERNAL SKIN TREATMENT THAT RETINOL INCLUDES. |
| EP04000012A EP1433477B1 (en) | 1992-07-13 | 1993-07-13 | Stabilised external skin treatment composition comprising retinol |
| AT93914997T ATE266999T1 (en) | 1992-07-13 | 1993-07-13 | DERMATOLOGICAL COMPOSITION |
| TW85115876A TW317502B (en) | 1992-07-13 | 1993-07-13 | |
| EP93914997A EP0608433B1 (en) | 1992-07-13 | 1993-07-13 | Composition for dermatologic preparation |
| TW82105572A TW302284B (en) | 1992-07-13 | 1993-07-13 | |
| EP06075806A EP1714640A1 (en) | 1992-07-13 | 1993-07-13 | Stabilised external skin treatment composition comprising retinol. |
| KR1019940700795A KR100295030B1 (en) | 1992-07-13 | 1993-07-13 | Skin external composition |
| AT04000012T ATE365530T1 (en) | 1992-07-13 | 1993-07-13 | STABILIZED SKIN CARE PRODUCT CONTAINING RETINOL FOR EXTERNAL USE |
| US08/429,905 US6024941A (en) | 1992-07-13 | 1995-04-27 | External skin treatment composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22772992A JP3455553B2 (en) | 1992-07-13 | 1992-07-13 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0632711A JPH0632711A (en) | 1994-02-08 |
| JP3455553B2 true JP3455553B2 (en) | 2003-10-14 |
Family
ID=16865446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22772992A Expired - Lifetime JP3455553B2 (en) | 1992-07-13 | 1992-07-13 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3455553B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07238010A (en) * | 1994-02-24 | 1995-09-12 | Kanebo Ltd | Skin cosmetic |
-
1992
- 1992-07-13 JP JP22772992A patent/JP3455553B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0632711A (en) | 1994-02-08 |
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