JP3195420B2 - Hydrocolloid type dressing material and functional external material using the same - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention finds application in a variety of medical applications, particularly in the field of wound dressings, incontinence and osteotomy.
Particularly, the present invention relates to a functional external material which is particularly effective for use in wounds which are difficult to treat such as chronic skin ulcer.

[0002]

BACKGROUND OF THE INVENTION Hydrocolloid adhesive compositions have been known for many years. That is, Chen disclosed in U.S. Pat. No. 3,339,549 one or more water-soluble or water-swellable rubber elastomers such as polyisobutylene and one or more powdered mixtures of pectin, gelatin and carboxymethylcellulose. A hydrocolloid type adhesive composition comprising a hydrocolloid is disclosed.

[0003] In this hydrocolloid adhesive composition, a rubber elastomer provides adhesion, and a hydrocolloid powder exhibits a function of absorbing wound exudate and body fluid, ie, a function as a dressing material.

[0004] The hydrocolloid dressings (adhesive compositions) are gaining increasing attention as dressings for skin ulcers, burns and other exudative wounds.

For example, Japanese Patent Application Laid-Open No. 58-190446 discloses a sealed multilayer bandage having an adhesive layer formed on one surface of an external moisture-impermeable polymer film with an intermediate layer made of a semi-open cell polymer foam interposed therebetween. Wherein said adhesive layer comprises one or more pressure sensitive adhesive materials and optionally one or more thermoplastic elastomers,
Consists essentially of a homogeneous blend of one or more water-dispersible hydrocolloids and, optionally, one or more water-swellable cohesive reinforcing agents and / or one or more hydratable polymers. A sealed multilayer bandage has been proposed.

However, this is a hermetically sealed bandage, and the hydrocolloid type adhesive layer swells with the absorption of wound exudate, body fluid, etc., and the components are separated from each other over time. The rubber elastomer (rubber-based adhesive) that bound the particles is separated and dispersed, and exists in a point state, that is, an independent state.

[0007] As a result, the relationship between the components constituting the hydrocolloid type adhesive layer is reduced, and as a result, not only does the shape-retaining property degrade and a part of the hydrocolloid-type adhesive layer flows out of the support, but also when it is applied to an affected area, Since the adhesive strength of the peripheral portion of the fixed portion is reduced and the portion is turned up, it cannot serve as an external material of the sticking type.

[0008] To solve this problem, it is conceivable to improve the adhesive strength of the rubber-based pressure-sensitive adhesive. The absorption capacity and absorption amount decrease, and the intended purpose cannot be achieved.

[0009] Therefore, recently, studies have been made on the hydrocolloid (polymer) side which is water-absorbing and / or water-swellable. For example, JP-A-2-13463
In Japanese Patent Application Laid-Open Publication No. H11-157, there is proposed a device using polycationic hydrocolloid particles and polyanionic hydrocolloid particles as hydrocolloid particles.

Examples of the polycationic hydrocolloid particles include water-soluble chitosan salts such as chitosan maleate and chitosan glutarate. Pectin as the polyanionic hydrocolloid particles,
Carboxymethyl cellulose, alginates and the like are mentioned.

[0011]

Although the above-mentioned structure can improve the binding force between the hydrocolloid particles to a certain extent, the adhesive force is still reduced due to the absorption of wound exudate and body fluid. The hydrocolloid type dressing material (adhesive composition) is dissolved by the absorption of the liquid, and flows out of the support.

It is conceivable to add various cross-linking agents to the hydrocolloid type dressing material. However, ordinary cross-linking agents have a strong skin irritating property, impair healing properties, and have a high p.
There are problems such as increasing H to facilitate the propagation of various bacteria and deteriorating the storage stability.

Further, when the ordinary crosslinking agent is used, the rising water absorption is good but does not last for a long time. Then, the swollen gel is dispersed and the liquid flows out, or the rising water absorption rate is slightly increased. There is a problem that the flow becomes insufficient and the liquid often flows out.

The present invention has been completed in view of the above technical problems, and comprises an adhesive composition comprising a rubber-based adhesive and a hydrocolloid powder comprising a specific polymer. The salt is mixed and dispersed in a particle state to form a hydrocolloid type dressing material, and this dressing material is applied to an affected area such as a wound,
When the wound exudate and bodily fluid are absorbed, the aluminum ion generated from the aluminum salt and the hydrocolloid powder composed of a specific polymer form an ionic bond or a coordinate bond, thereby improving the binding force of the adhesive layer to improve the dressing. It maintains the shape retention of the material, prevents its dissolution and outflow, and improves the adhesion with the affected part.
This dressing material has a good water absorption rate at the start,
In addition, it effectively absorbs bodily fluids such as wound exudate and prevents bodily fluids from flowing out from the surface of the application site, so that it is hygienic. Further, aluminum salts have no or little skin irritation and are curable. It is an object of the present invention to provide a hydrocolloid-type dressing material which is safe because it promotes germination and suppresses the propagation of various bacteria, and has excellent storage stability, and a functional external material using the same.

[0015]

In order to achieve the above object, a hydrocolloid type dressing material of the present invention comprises a rubber adhesive, polyacrylic acid and / or polyacrylic acid.
Salt, acrylic acid / vinyl alcohol copolymer, crosslinked
Ruboxymethylcellulose (sodium salt and calcium
Contains salt. ), Length of methyl vinyl ether / maleic acid
Chain polymer, carboxymethylcellulose (sodium
Contains salts and calcium salts. ), Starch-acrylate acrylate
Polymer, carboxycellulose-acrylate
Raft polymer, acrylic acid-acrylamide copolymer
-, Alginic acid and / or its soda salt, methyl vinyl
Ether / maleic anhydride copolymer, gelatin, pek
Selected from chin, carrageenan, polyvinylpyrrolidone
The adhesive composition with the hydrocolloid powder comprising at least one polymer has a solubility in water of 5 g /
It is characterized in that a readily soluble aluminum salt of 100 g or more is mixed and dispersed in a particle state.

That is, in the hydrocolloid type dressing material of the present invention, the rubber-based adhesive and the specific
In an adhesive composition comprising a hydrocolloid powder of
Further, a readily soluble aluminum salt having a solubility in water of 5 g / 100 g or more is mixed and dispersed in a particle state.

The rubber-based adhesive used in the present invention is not particularly limited as long as it imparts adhesiveness when dried. Natural or synthetic viscous rubbery substances,
For example, at least one selected from natural rubber, polyisobutylene rubber, polyurethane rubber, silicone rubber, acrylonitrile rubber, etc., of which viscosity average molecular weight (Flowry method) is about 36,000 to 12,000
Low molecular weight polyisobutylene of 0 is desirable because it has excellent adhesion.

[0018] as a hydrocolloid Powder consisting of water-absorbing and / or water-swellable polymers used in the present invention, been made to exhibit adhesive properties when wet, which will be described later, salt formation ability and / or A polymer having a functional group having a coordinating ability, and particularly when immersed in a physiological saline, is preferably a polymer having a high permeability and a large liquid absorbing power.

The hydrocolloid powder used in the present invention
The polyacrylic acid and / or salts thereof, acrylic acid / vinyl alcohol copolymers, crosslinked carboxymethylcellulose (containing sodium salt or calcium salt.),
Methyl vinyl ether / maleic acid long chain polymer, carboxymethyl cellulose (including sodium salt and calcium salt), starch-acrylate graft polymer,
Examples include at least one selected from carboxycellulose-acrylate graft polymers, acrylic acid-acrylamide copolymers, alginic acid and / or soda salts thereof, methyl vinyl ether / maleic anhydride copolymers, gelatin, pectin, carrageenan, and polyvinylpyrrolidone .

The most significant feature of the present invention is that an aluminum salt which is easily soluble in water is mixed and dispersed in the adhesive composition containing the rubber adhesive and hydrocolloid powder as essential components. It is in the point.

The aluminum salt used in the present invention is not particularly limited as long as it is easily soluble in 5 g or more with respect to 100 g of water. Inorganic aluminum salts, organic aluminum salts or a mixture thereof is used. No.

Specific typical examples include, for example, alum, calcined alum, aluminum sulfate (anhydride, hydrate), aluminum nitrate hydrate and / or aluminum lactate, aluminum salicylate and the like.

In the present invention, alum is

[0024]

(Equation 1)

Of the double salts that can be represented by the general formula,

[0026]

(Equation 2)

[0027] The trivalent metal corresponding to aluminum is aluminum, and includes aluminum ammonium sulfate hydrate, aluminum potassium sulfate hydrate, aluminum sodium sulfate hydrate, and the like. Alum is heated to make it anhydrous.

In the present invention, the aluminum salt is mixed and dispersed in the adhesive composition in the form of particles. Dispersibility, dissolution rate when absorbing wound exudate, body fluid, etc., and release of aluminum ions From the viewpoint of the above, it is desirable that the average particle size of the aluminum salt is 1000 μm or less, particularly 300 μm or less.

In the present invention, the mixing ratio of the rubber-based adhesive (A), the hydrocolloid powder (B), and the aluminum salt (C) depends on the adhesiveness to the application site of the human body,
From the viewpoints of the speed and amount of water absorption or water swelling and the shape retention of the adhesive layer, the above (A) is in the range of 15 to 70% by weight, particularly 35 to 50% by weight, and the above (B) is in the range of 35 to 50% by weight. 10
It is desirable that the content be 75% by weight, particularly 40 to 65% by weight, and that the content of the above (C) be 0.1 to 20% by weight, particularly 1 to 10% by weight.

In this case, examples of the kneading include known kneading machines such as a kneader mixing roll, a Banbury mixer, a twin-screw kneader, a Henschel mixer and an extrusion kneader.

As a preferred embodiment of the hydrocolloid type dressing material of the present invention, from the viewpoints of releasing metal ions slowly over a long period of time and maintaining continuous water absorption,
It is desirable to mix a metal oxide and / or metal salt which is less soluble than the above-mentioned aluminum salt and which can be ion-crosslinked.

The ion-crosslinkable metal oxide and / or metal salt is not particularly limited as long as it has a solubility of less than 5 g in 100 g of water.
An inorganic aluminum salt, an organic aluminum salt, or a mixture thereof may be used.

Specific examples thereof include, for example, zinc benzoate (anhydrous, monohydrate), zinc citrate, zinc carbonate, zinc lactate (trihydrate, dihydrate D form), Zinc oxide
(Zinc white), zinc salicylate trihydrate, zinc sulfide, zinc sulfite hydrate, calcium benzoate hydrate, calcium carbonate, calcium citrate tetrahydrate, calcium fluoride,
Calcium glycerate dihydrate, calcium hydroxide,
Calcium hydrogen phosphate (anhydride, dihydrate), calcium dihydrogen phosphate monohydrate, tricalcium phosphate, calcium phosphite hydrate, calcium sulfate (dihydrate, anhydrous), calcium sulfite water Japanese, calcium tartrate tetrahydrate, calcium thiocyanate, aluminum benzoate
(Anhydride), aluminum citrate, aluminum phosphate hydrate, aluminum hydroxide and the like.

Among the above, the most desirable combination is that the particularly insoluble metal salt is an anhydrous aluminum salt and the insoluble metal oxide is aluminum hydroxide. In particular, long-term sustained release of aluminum ions is further improved, and continuous water absorption is realized with a high water absorption rate by aluminum ions.

The compounding amount of the hardly soluble metal oxide and / or the hardly soluble metal salt is such that the hardly soluble aluminum salt (C) 1
The amount is from 10 to 5,000 parts by weight, especially from 20 to 1,000 parts by weight, preferably from 20 to 1,000 parts by weight.
Exceeding the weight part is not desirable because the amount may be too large and the balance with other components may be lost, so that the above object may not be achieved. In this case, the above-described kneader is suitably used for this kneading.

In the present invention, if desired, another rubber elastomer can be blended with the above-mentioned hydrocolloid-type dressing material in order to improve adhesiveness and stretchability.

Specific examples of the rubber elastomer include a high molecular weight polyisobutylene having a viscosity average molecular weight of about 1,000,000 to 2,000,000, a copolymer of isobutylene and a small amount of isoprene, and a viscosity average molecular weight of about 50 to 150,000,000.
Styrene copolymers such as styrene-butadiene-styrene (SBS) and styrene-isoprene-styrene (S-I-S) and styrene-ethylene / butylene-styrene (S-EB-S) But preferably a styrene-isoprene-styrene block polymer.

In this case, the compounding ratio of the rubber elastomer is preferably in the range of 0.5 to 20% by weight, particularly 2 to 8% by weight of the whole hydrocolloid type dressing material. If it is less than 0.5% by weight, it is meaningless to mix, while if it exceeds 20% by weight, the concentration of the rubber-based adhesive (A) or the specific hydrocolloid powder (B) is relatively reduced, and the adhesive strength is reduced. This is not desirable because the absorption characteristics of exudate may be reduced. For the kneading in this case, the above-described kneader is suitably used.

In the present invention, if desired, a plasticizer or a solvent, for example, a tackifier such as mineral oil or petrolatum, mineral oil or a terpene resin can be added to the adhesive layer.

The mixing ratio of the plasticizer, the solvent, or the tackifier is preferably in the range of 1 to 20% by weight, particularly 3 to 10% by weight of the whole hydrocolloid type dressing material. If the amount is less than 20% by weight, the content of the rubber adhesive (A) or the specific hydrocolloid powder (B) is relatively reduced, and the exudate absorption characteristics are reduced. It is not desirable because of fear. For the kneading in this case, the above-described kneader is suitably used.

Further, in the present invention, if desired, another water-absorbing and / or water-swelling polymer may be contained in the hydrocolloid-type dressing material.
In this case, in order to maintain the shape retaining property of the adhesive layer, its content is desirably adjusted to 30% by weight or less of the whole dressing material. If the content exceeds 30% by weight, the shape retention may be lost and a part may flow out. For the kneading in this case, the above-described kneader is suitably used.

The examples are not particularly limited as long as they exhibit adhesiveness when wet, and are, for example, karaya gum, guar gum, locust bean gum, polyvinyl alcohol, polyethylene glycol, polyacrylamide, water-insoluble starch. -At least one selected from acrylonitrile graft polymers, water-insoluble crosslinked dextrins, and the like.

In the functional external material of the present invention, the above-mentioned hydrocolloid-type dressing material is laminated on a support.
From the viewpoint that the handleability is good, and the support protects the hydrocolloid type dressing material, the shape retention is realized, the long-term use is possible, and the stain on the clothes can be prevented. desirable.

The support used in the present invention is not particularly limited as long as it is flexible and waterproof, and therefore, is a nonporous or porous film or sheet, or a foamed sheet. Any combination of these can be used, and examples of the material include those formed of a natural material or a synthetic material. Among them, the support formed of a synthetic resin is particularly strong, expensive, and excellent. It is desirable from the viewpoint of easy securing of elasticity.

When a foamed sheet is used as this support, it is desirable to attach another film or sheet having a bacterial barrier property to a continuous porous material in order to impart moisture permeability and bacterial barrier properties.

The thickness of the support is 10-20.
It is desirable to use a film having a thickness of 0 μm, particularly 20 to 150 μm. If the thickness is too thin, less than 10 μm, problems arise in strength and handleability.
If it exceeds 00 μm, it is not preferable because it becomes too thick, resulting in reduced adhesion to the application site of the human body, a problem in handling, and an economic disadvantage.

On the other hand, when a foamed sheet is used as the support, it is preferably a continuous porous sheet to provide cushioning property, moisture permeability and bacterial barrier property, and has a thickness of 100 to 5000 μm. And preferably 300 to 2000 μm.

The support made of the synthetic resin is not particularly limited. For example, polyethylene resin, polypropylene resin, polyester resin, polyurethane resin, polyamide polyether urethane resin, polyvinyl chloride resin, polyvinylidene chloride resin, A non-porous or porous film or sheet made of at least one resin selected from the group consisting of polyamide resins and the like, that is, a mono-layer, two-layer or three or more layers formed of these resins Either a hole or a porous film or sheet may be used.

In this support, those using a polyethylene resin, particularly a linear low-density polyethylene resin, are excellent in the production and processability of the support, the production cost is low, and the obtained support is extensible. It is most preferable because of high strength and high strength.

The linear low-density polyethylene resin is a copolymer of ethylene and an α-olefin, and examples of the α-olefin include butene, hexene and octene.

The support made of the synthetic resin may include, if desired, a filler blended therein. Examples of the filler include calcium carbonate, talc, clay, kaolin, silica, barium sulfate, kaolin sulfate, and kaolin sulfate. Examples include aluminum hydroxide, zinc oxide, calcium oxide, titanium oxide, alumina, and mica.

The filler has an average particle diameter of 30 μm or less, and preferably in the range of 0.1 to 10 μm. In addition, from the standpoint of making bacterial barrier properties a necessary property, those having an average pore diameter of 0.5 μm or less are desirable.

When the particle size exceeds 30 μm, the particle size is too large, and when a porous film or sheet is obtained, the water vapor permeability becomes too large because the through holes become large, and conversely, it is too small, less than 0.1 μm. Aggregation occurs and dispersibility is poor, which is not preferable.

In the present invention, when a polyethylene resin or a polypropylene resin is used, the kneading and dispersing properties of the filler are improved, the shaping and processing properties are improved, or the functional strength of the film is improved. In order to
An olefin terpolymer or a softener may be blended.

The olefin terpolymer is not particularly limited as long as it is a rubber-like substance having a number average molecular weight of 5,000 to 200,000. Specific examples thereof include ethylene, α-olefin and non-conjugated diolefin. A cyclic or non-cyclic copolymer having a heavy bond (hereinafter referred to as E
PDM) is used.

The EPDM is a terpolymer composed of ethylene, propylene or butene-1 and the polyene monomers listed below. Examples of the polyene monomer include dicyclopentadiene, 1,5-cyclooctadiene, 1,1- Cyclooctadienes, 1,6-cyclododecadienes, 1,7-cyclododecadienes, 1,5
9-cyclododecatriene, 1,4-cycloheptadiene, 1,4-cyclohexadiene, 1,6-heptadiene, norbornadiene, methylene norbornene, 2-methylpentadiene-1,4,1,5-hexadiene, methyl-tetrahydro Indene, 1,4-hexadiene and the like. The copolymerization ratio of each monomer is preferably 30 to 80 mol% for ethylene and 0.1 to 2 for polyene.
Mooney viscosity of a terpolymer with 0 mol% remaining α-olefin

[0057]

(Equation 3)

It is preferable that the number is 1 to 60.

The softener is not particularly limited as long as it has a number average molecular weight of 1,000 to 30,000, and specific examples thereof include petroleum-based process oils as low-viscosity softeners, There are liquid paraffin, aliphatic oils and low molecular weight plasticizers, and softening agents such as polybutene, low molecular weight polyisobutylene and liquid rubber are preferably used as relatively high viscosity softening agents.

Incidentally, the thermoplastic porous film includes:
Ordinarily used antioxidants, ultraviolet stabilizers, antistatic agents, pigments, lubricants, fluorescent agents and the like may be added.

The above-mentioned hydrocolloid type dressing material is laminated on the support, and the layer thickness is generally 200 to 3000 μm, especially 1000 to 200 μm.
If the thickness is too thin, less than 200 μm, the adhesive strength is reduced, the cushioning property is reduced, and there is a problem in the adhesion to the application site of the human body, and the liquid absorption is small. On the other hand, it is not preferable because
If the thickness exceeds 00 μm, it is not preferable because it becomes too thick and causes a problem in adhesion to a human body, or it becomes too thick and easily comes off, or a local stress is applied.

For forming the hydrocolloid type dressing material layer, a known method such as solvent coating, rolling with a roll, or extrusion with an extruder is employed. In the case of forming a hydrocolloid type dressing material layer by this solvent coating, since this layer thickness is 200 μm or more, a plurality of coatings are required, and it is not necessarily economical. It is desirable to use an extrusion method.

In the present invention, a porous support is used. As the porous support, a film or sheet formed of the above synthetic resin can be perforated with a fine needle, uniaxially or biaxially stretched. It is formed directly into a porous material or formed into a porous material by stretching.
Those formed by eluting the filler with alkali or water or the like can be mentioned. In this case, a thin highly moisture-permeable film can be laminated on the surface of the porous body to have a bacterial barrier property.

The porous support has a moisture permeability of 300 to 2000 g / m ² · 24 hr, particularly 500 to 2000 g / m ² · 24 hr.
Those at 1500 g / m ² · 24 hr are beneficial.

The moisture permeability of the support is 300 g / m ² · 24 h
If it is less than r, the moisture permeability is too small and the moisture in the wound exudate absorbed by the dressing material layer evaporates poorly from the surface of the support, causing a change in the components of the adhesive layer. May flow out, while the moisture permeability is 200
If it exceeds 0 g / m ² · 24 hr, the moisture permeability is too large,
Undesirably, the components in the dressing layer evaporate and dry the wound surface, resulting in a delay in healing.

In the present invention, the moisture permeability is a value measured by the Paynes cup method.

The thickness of the moisture-permeable support is 10
It is desirable to form a film having a thickness of from 100 μm to 100 μm, especially from 20 to 80 μm. If the thickness is less than 10 μm, it is not preferable because a problem arises in strength and handleability. It is not preferable because the adhesiveness of the human body to the application site is reduced, the handling is problematic, and the moisture permeability is reduced.

On the other hand, when a foamed sheet is used for the support, it is preferably a continuous porous one to impart moisture permeability and bacterial barrier properties, and has a thickness of 100 to 5,000.
μm, preferably 300 to 2000 μm
m is good.

In the present invention, an antibacterial substance is added to the adhesive layer.
For example, ibitone such as hibitene, benzalkonium chloride, benzethonium chloride, povidone iodine, silver sulfadiazine, sulfuric acid and antibiotics such as fradiomycin sulfate, gentamicin sulfate, etc.
Seeds can be added in combination or in combination, and the amount of addition is in the range of 0.01 to 20%, preferably 0.05 to 5%, to disinfect or sterilize the application site of the human body and to prevent the growth of bacteria. It is desirable.

[0070]

The hydrocolloid-type dressing material of the present invention has the above-mentioned constitution, and the adhesive layer is adhered to an application site of a human body such as a wound site.

The wound exudate and bodily fluid are initially rapidly absorbed by the water-absorbing polymer and / or water-swellable polymer in the hydrocolloid type dressing, and
In a readily soluble aluminum salt mixed in the form of fine powder, the release of aluminum ions from the surface of the fine particles rapidly and continuously occurs.

The released aluminum ions have remarkably high ionic crosslinkability, and are adjacent to the water-absorbing polymer and / or
Alternatively, the water-swellable polymer is quickly and efficiently cross-linked, and has an effect of maintaining shape retention over a long period of time and sustaining high water absorption.

In this case, since the fine powder of the aluminum salt and the hydrocolloid powder are well mixed with each other, the probability of contact with each other is high, and from this point, ionic crosslinking is likely to occur.

In the present invention, when a sparingly soluble metal salt and / or a sparingly soluble metal oxide is used, the metal ion is gradually released over a long period of time, and the effect of maintaining more continuous water absorption can be obtained. It has.

In the functional external material of the present invention, the above-mentioned hydrocolloid type dressing material is laminated on the support, so that the handleability is good, and the support protects the hydrocolloid type dressing material. It has the effect of maintaining shape retention.

[0076]

The present invention will be described below in detail with reference to examples, but the present invention is not limited to these examples.

[0077] Structure Example FIG 1 of a functional bandage of the present invention is a perspective view of a functional bandage of the present invention, FIG. 2 is a longitudinal sectional view thereof. 1 and 2, the functional external use material 1 of the present invention is formed by forming a hydrocolloid type dressing material layer 3 on one surface of a support 2. In this case, the support 2 is permeable to moisture. Hydrocolloid particles composed of a water-absorbing and / or water-swelling polymer have a functional group having a salt-forming ability and / or a coordination ability. In addition, 4 is a peelable separator.

Example 1 Potassium alum, which is a crystalline powder, was crushed and finely ground in a mortar in advance, and uniformly mixed with a kneader at a mixing ratio described below to obtain a hydrocolloid composition.

Mixing ratio of hydrocolloid composition CCMNa 17.5 parts by weight Pectin 12.5 parts by weight Gelatin 19.5 parts by weight Potassium alum 3.0 parts by weight White petrolatum 0.5 parts by weight The above-mentioned CMCNa is a sodium salt of carboxymethyl cellulose. That is.

Next, polyisobutylene (viscosity average molecular weight (Flowry method)) was added to 58 parts by weight of the hydrocolloid composition.
70,000) and 42 parts by weight were mixed well with a small kneader to obtain a hydrocolloid type dressing material of the present invention.

Further, this hydrocolloid type dressing material was formed into a 1.3 mm thick sheet by a press machine to obtain the dressing material layer 3.

Then, a polyurethane film (35 μm) was used as the support 2, and the above-mentioned dressing material layer 3 was laminated on one surface thereof to obtain a functional external use material 1 of the present invention.

At this time, potassium alum particles in the hydrocolloid type dressing material layer 3 were confirmed by elemental analysis, and the size thereof was measured by electron microscopic observation. The number average was 15 μm.

Example 2 A hydrocolloid composition was obtained by uniformly stirring and mixing a potassium aluminum sulfate powder (decahydrate) and aluminum hydroxide in a mixing ratio described below with a kneader.

Mixing ratio of hydrocolloid composition 16.5 parts by weight of CMCNa 15.5 parts by weight of pectin 18.5 parts by weight of gelatin 1 part by weight of PVP 2.0 parts by weight of potassium alum 2.0 parts by weight of aluminum hydroxide 2.0 parts by weight of the above PVP Is polyvinylpyrrolidone.

Next, polyisobutylene (viscosity average molecular weight (Flowry method)) was added to 58 parts by weight of this hydrocolloid composition.
= 70,000) and 42 parts by weight of a 14: 1 mixture (weight ratio) of natural rubber were sufficiently kneaded with a small kneader to obtain a hydrocolloid type dressing material of the present invention.

The dressing material layer 3 was obtained by forming the hydrocolloid type dressing material into a 1.5 mm thick sheet using a press machine.

Further, a polyurethane film (40 μm) was used as the support 2, and the hydrocolloid type dressing material layer 3 was laminated on one surface thereof to obtain the functional external use material 1 of the present invention.

Example 3 A hydrocolloid composition was obtained by uniformly stirring and mixing potassium aluminum sulphate powder (hydrate) and calcined alum in a mixing ratio described below in a kneader.

Mixing ratio of hydrocolloid composition CMCNa 20.0 parts by weight Pectin 20.0 parts by weight Gelatin 5.0 parts by weight PVP 0.8 parts by weight Potassium alum 2.0 parts by weight Baked alum 2.0 parts by weight Means polyvinylpyrrolidone.

Next, in the same manner as in Example 2, the hydrocolloid-type dressing material of the present invention and
A functional external use material of the present invention was obtained.

Example 4 A functional external material of the present invention was obtained in the same manner as in Example 2, except that aluminum potassium hydroxide powder was used instead of aluminum hydroxide.

Example 5 A functional external material of the present invention was obtained in the same manner as in Example 3 except that potassium aluminum sulfate was used instead of calcined alum.

Reference Example A functional external material was obtained in the same manner as in Example 1 except that potassium alum, which was not powdered, was used.

The size of the potassium alum particles in the hydrocolloid type dressing material layer at this time was determined in Example 1.
As a result, the number average was 1200 μm.

Comparative Example 1 An external material was prepared in the same manner as in Example 1 except that aluminum hydroxide was used instead of potassium alum.

Comparative Example 2 An external material was prepared in the same manner as in Example 1, except that zinc sulfate was used instead of potassium alum.

Comparative Example 3 An external material was produced in the same manner as in Example 1 except that aluminum oxide was used instead of potassium alum.

Comparative Example 4 An external use material was obtained in the same manner as in Example 1 except that potassium alum was removed and other hydrocolloid components were increased in the same ratio.

Using the samples of the above Examples and Reference Examples and Comparative Examples, the results of measuring the change over time in the amount of liquid absorbed in physiological saline by the method described below are shown in FIG.
6 to FIG.

The size of the adhesive layer of the subject was 20 mmφ ×
One test sample was immersed in 100 ml of physiological saline at 1.3 ° C. at a thickness of 1.3 mm, and the water absorption over time was measured by weight measurement using the formula 4.

[0102]

(Equation 4)

From the results shown in FIG. 3, it is recognized that the smaller the size of potassium alum, the better the rise of water absorption and the higher the water absorption.

Further, from the results shown in FIG. 4, those using potassium alum (Example 1), that is, those using a readily soluble aluminum salt show the most excellent water absorption properties,
Next, one using aluminum hydroxide (Comparative Example 1),
In the case of the one using zinc sulfate (Comparative Example 2) and the one using aluminum oxide (Comparative Example 3), the water absorption characteristics deteriorate in order,
In particular, it was found that the case using no ionic crosslinking agent (Comparative Example 4) was the worst.

In particular, from the results shown in FIG.
In the case of the sample, the layer of the hydrocolloid type dressing material began to disperse, and the measurement became impossible on the way.

From the results shown in FIGS. 5 and 6, when the amount of the easily soluble aluminum salt is increased, the rise of the water absorption is good. On the other hand, the addition of the easily soluble aluminum salt and the slightly soluble aluminum salt is the most excellent. It is noted that the water-absorbing property of the steel sheet is improved.

Further, when the above-mentioned subject was stuck on the rat skin wound and the appearance was observed, the results in each of the examples and reference examples were 3
No outflow of exudate was observed even after one day, but that of Comparative Example 4 was one day, and that of Comparative Example 3 was one day,
The outflow of the hydrocolloid-type dressing material was observed in 2 days in Comparative Example 2 and 2 days in Comparative Example 1, respectively.

[0108]

According to the hydrocolloid type dressing material of the present invention, the adhesive composition comprising the rubber-based adhesive and the hydrocolloid powder composed of a specific polymer has a water-soluble aluminum content. The salt is mixed and dispersed in the form of particles to form a hydrocolloid type dressing material. When this dressing material is applied to an affected area such as a wound and absorbs wound exudate and body fluid, it is identified as aluminum ions generated from aluminum salts. Hydrocolloid powder composed of a polymer forms an ionic bond or a coordinate bond, thereby improving the binding force of the adhesive layer, maintaining the shape retention of the dressing material, preventing its dissolution or outflow, This dressing material improves the adhesion to the affected area, and this dressing material has a good rising water absorption rate. It is also hygienic because it effectively absorbs bodily fluids such as wound exudate and prevents bodily fluids from flowing out from the surface of the application site. Furthermore, aluminum salts have no or little skin irritation and are curable. It is safe because it promotes the growth of bacteria and suppresses the propagation of various bacteria, and has the effect of having excellent storage stability.

Further, in the functional external use material of the present invention, since the excellent hydrocolloid type dressing material is laminated on the support, the handleability is good, and the support uses the hydrocolloid type dressing material. It is extremely beneficial because it protects and maintains its shape retention and can be used effectively over a long period of time.

[Brief description of the drawings]

FIG. 1 is a perspective view showing one embodiment of a functional external material of the present invention.

FIG. 2 is a sectional view of the same.

FIG. 3 is an absorption characteristic diagram of physiological saline in Example 1 and Reference Example.

FIG. 4 is an absorption characteristic diagram of physiological saline in Example 1 and Comparative Examples 1 to 4.

FIG. 5 is a graph showing absorption characteristics of physiological saline in Examples 2 and 4.

FIG. 6 is a graph showing absorption characteristics of physiological saline in Examples 3 and 5.

[Explanation of symbols]

 Reference Signs List 1 functional external use material 2 support 3 hydrocolloid type dressing material layer 4 separator

──────────────────────────────────────────────────続 き Continued on the front page (56) References JP-A-63-156717 (JP, A) JP-A-57-106615 (JP, A) JP-A-6-125977 (JP, A) (58) Field (Int.Cl. ⁷ , DB name) A61K 9/00-9/72 A61L 15/00-15/64 A61F 13/00-13/84

Claims (6)

(57) [Claims] 1. A rubber adhesive, polyacrylic acid and / or
Or its salt, acrylic acid / vinyl alcohol copolymer
ー, cross-linked carboxymethyl cellulose (sodium salt or
Contains calcium salts. ), Methyl vinyl ether / male
Carboxymethylcellulose, long-chain polymer of formic acid
(Including sodium and calcium salts), starch
Lylate salt graft polymer, carboxycellulose-A
Crylate salt graft polymer, acrylic acid-acrylic acid
A mid copolymer, alginic acid and / or a soda salt thereof,
Methyl vinyl ether / maleic anhydride copolymer,
Latin, pectin, carrageenan, polyvinylpyrrolid
Water-soluble composition in an adhesive composition with a hydrocolloid powder comprising at least one polymer selected from the group consisting of
A hydrocolloid type dressing material , wherein a readily soluble aluminum salt having a resolution of 5 g / 100 g or more is mixed and dispersed in a particle state. 2. The hydrocolloid type dressing material according to claim 1, wherein the average particle size of the aluminum salt in the hydrocolloid type dressing material is 1000 μm or less. 3. The method according to claim 1, wherein the aluminum salt is alum, calcined alum, aluminum sulfate, aluminum salicylate,
The hydrocolloid type dressing material according to claim 1, which is at least one selected from aluminum nitrate and aluminum lactate. 4. The solubility in water is less than 5 g / 100 g.
Having a solubility in a poorly soluble metal salt and / or water of 5
The hydrocolloid type dressing material according to any one of claims 1 to 3, further comprising a sparingly soluble metal oxide of less than g / 100 g . 5. A solubility in water of less than 5 g / 100 g.
Having a solubility in a poorly soluble metal salt and / or water of 5
The hydrocolloid type dressing material according to claim 4 , wherein the hardly soluble metal oxide having a weight of less than g / 100g is an anhydrous aluminum salt and / or aluminum hydroxide. 6. A functional external material in which the hydrocolloid type dressing material according to claim 1 is laminated on a support.