JP3193542B2 - Anti-aging skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic for preventing skin aging (a cosmetic used for preventing skin aging). More specifically, skin aging prevention effects (rough skin improvement effect, keratin improvement effect, effect of increasing turnover speed, beautiful skin effect, etc.)
Related to excellent skin cosmetics.

[0002]

2. Description of the Related Art Aged skin is rough skin that is dry and has no smoothness and in which keratinocyte exfoliation is observed. And aging skin,
It is said that the turnover speed is low when the skin has an anti-aging effect, and the turnover speed is high. The present applicant has previously found that γ-amino-β-hydroxybutyric acid enhances skin functions and has an anti-aging effect, and has proposed the same (Japanese Patent Publication No. 1-13685).

[0003] On the other hand, assembly extracts, carrot extracts, etc. are known substances and only have a blood circulation-promoting effect. They promote skin functions similar to γ-amino-β-hydroxybutyric acid and salts thereof, and prevent aging. It has not been found to have any effect.

[0004] However, skin cosmetics comprising solely a skin stimulant, which is a component that enhances skin functions, are:
In all cases, the effects such as anti-aging are slow-acting, and it takes a long time for the effects to appear, so that they are not sufficiently satisfactory, and there is still room for improvement.

[0005] In view of such circumstances, the present inventor has excellent skin aging prevention effects (rough skin improvement effect, keratin improvement effect,
The effect of increasing the speed of turnover, the beautiful skin effect, etc.)
As a result of intensive studies as to whether or not there is a fast-acting skin aging preventive cosmetic which is expressed in a very short time of 1 to 2 months after the start of use and is persistent, γ-amino-β-hydroxybutyric acid and a salt thereof The present inventors have found that this object can be achieved by blending the assembly extract and / or the carrot extract with at least one selected from the group consisting of: and completed the present invention.

[0006]

That is, the present invention provides γ
-Amino- [beta] -hydroxybutyric acid and a salt thereof, and at least one selected from the group consisting of an assembly extract and / or a carrot extract.

Hereinafter, the configuration of the present invention will be described in detail. In order to achieve the above object, the skin aging preventive cosmetic of the present invention comprises (a) at least one selected from the group of γ-amino-β-hydroxybutyric acid and salts thereof, and (b) assembly extract and / or And a carrot extract. The present inventor has investigated the compounding ratio which maximizes the synergistic effect of the above-mentioned constituents contained in the skin aging preventive cosmetic, and as a result, (a) from the group of γ-amino-β-hydroxybutyric acid and salts thereof. In the combination of at least one selected and (b) the assembly extract and / or carrot extract, the ratio (weight ratio) of the respective compounding amounts is preferably (a) :( b) = 1: 1 to 30. The excellent effects aimed at by the present invention were recognized.

[0008] As mentioned above, the skin aging preventive cosmetic of the present invention comprises at least one member selected from the group consisting of γ-amino-β-hydroxybutyric acid and salts thereof, and an assembly extract and / or a carrot extract. Both of which act synergistically on the skin to dilate peripheral blood vessels of the skin, enhance skin function, prevent skin wrinkles, and provide fine and firm skin (Beautiful skin effect) as well as excellent skin aging prevention effects (rough skin improvement effect, keratin improvement effect, and effect of increasing turnover speed) in a short time, and exhibit remarkable effects such as sustaining.

As described above, γ-amino-β-hydroxybutyric acid and salts thereof applied to the present invention are known compounds and are described in detail in the above publication. γ-amino-
As the salts of β-hydroxybutyric acid, potassium, sodium, calcium and magnesium salts of γ-amino-β-hydroxybutyric acid neutralized with either caustic potash, caustic soda or calcium hydroxide or magnesium hydroxide Is applied.

The assembly used in the present invention (Swertia)
Japanica Makino) is a known substance, and is an extract obtained by digesting a dried and crushed whole flowering plant in ethanol or hydrous ethanol and filtering off. Extracts obtained by the following methods were applied to Examples and Comparative Examples. 50 g of the crushed assembly is added to 250 ml of aqueous ethanol (ethanol 90% by weight) at a temperature of 40 to 50 ° C.
And the residue was similarly digested again several times to obtain 1.5 l of extract. 100 ml of purified water was added to the residue which was concentrated under reduced pressure. After aging for 1 week, the extract obtained by filtering off the insoluble portion was concentrated under reduced pressure, and then ethanol was added to reduce the ethanol content of the extract to 40% by weight. To obtain 100 ml of assembly extract. (Note that after 100 g of this extract was concentrated under reduced pressure, it was extracted with 200 ml of ethyl acetate (40 ml × 5 times), and then ethyl acetate was distilled off from this extract under reduced pressure to give a residue of 0.95 to 1.05 g. .)

The ginseng used in the present invention is also a known substance, such as Panax ginseng.
Seng C.I. A. Meyer) is an extract obtained by immersing the dried ground comminuted product of Meyer) in ethanol or hydrated ethanol and filtering off. Extracts obtained by the following methods were applied to Examples and Comparative Examples. 50 g of the ginseng ginseng was cold-immersed in 200 ml of water-containing ethanol (ethanol 90% by weight) for 1 week, the ethanol of the extract obtained by filtration was distilled off, and purified water was added to reduce the ethanol content of the extract to 50% by weight. The resulting mixture was aged in a cool place for 7 to 10 weeks, and then filtered to obtain 100 ml of a Korean ginseng extract. (In addition, this extract 10.0
g was concentrated under reduced pressure, 30 ml of purified water was added and dissolved, and the aqueous solution was filtered. Then, ether 40 was added to the filtrate.
Add the ml and shake gently.
The lower aqueous solution was separated. Further, the aqueous solution is saturated with water.
-120 ml of butanol (40 ml x 3 times) was added and shaken vigorously. After standing for a while, the butanol layer was separated, and the butanol solution was heated on a water bath to remove n-butanol. 1.2 g. )

The compounding amount of γ-amino-β-hydroxybutyric acid and its salt is 0.1% based on the total amount of the ingredients of the cosmetic.
1 to 2% by weight (hereinafter abbreviated as wt%).

The amount of the assembly extract is preferably 0.1 to 5.0 wt% based on the total amount of the prescription components of the cosmetic.
%.

The amount of the carrot extract is preferably 0.1 to 5.0 wt% based on the total amount of the ingredients of the cosmetic.
%.

The cosmetics of the present invention include, in addition to the above-mentioned raw materials, tar pigments, coloring pigments such as iron oxide, preservatives such as paraben, anionic surfactants such as fatty acid soap and sodium cetyl sulfate, polyoxyethylene. Nonionic surfactants such as alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid esters, and polyglycerin fatty acid esters; Ionic surfactants, amphoteric surfactants such as betaine type, sulfobetaine type, sulfoamino acid type, sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, titanium oxide and the like Pigment, dibutyl hydroxy And antioxidants such as toluene, may be appropriately blended within the range to achieve the object of the present invention.

The cosmetic preparation of the present invention includes creams, emulsions, lotions, packs and the like. For example, in the case of a cream or the like, this cosmetic can be produced by a usual method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, followed by cooling.

[0017]

The present invention will be described below in detail based on examples and comparative examples. The methods for measuring the turnover speed of the stratum corneum, the method for measuring the effect of improving rough skin, the method for measuring the effect of improving stratum corneum, and the sensory test described in the examples are as follows.

Method for measuring the turnover speed of the stratum corneum 5 wt% of the fluorescent dye dansyl chloride was added to white petrolatum.
% Ointment is prepared, and occlusively applied to the skin of the forearm of the subject for 24 hours to allow dansyl chloride to penetrate into the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover speed of the stratum corneum of the skin. In addition, the turnover speed of the normal skin stratum corneum is 14 to 16 days, but it extends around 18 days in aged skin. On the other hand, when the anti-aging effect appears, it is reduced to around 12 days.

Measurement Test Method for Improvement of Rough Skin The effect of continuous application for 20 weeks was examined on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of the sample was applied to the test site of the left leg of the subject twice a day, and the skin condition before and after the start of the test was determined according to the criteria shown in Table 1. The lower leg on the right side was used as a sample without application.

[0020]

[Table 1]

The test results before and after the test and the control site are compared, and when the degree of dryness of the skin is improved by two or more stages (for example, + →-, ++ → ±), “effective” and one stage of improvement Is "Slightly valid", and the case where there is no change is "Invalid". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

Measurement test method of keratin improvement (enhancement of exfoliation of keratinocytes) effect Scotch tape (Nichiban Mending tape) is applied to the skin of a test part before and after the above-mentioned measurement test for measuring rough skin improvement.
Was adhered to the tape, and when the tape was peeled off, the state of the keratinous cells attached to the tape was examined in detail by a scanning electron microscope.

[0023]

[Table 2]

The judgment is "valid" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 or more, "valid" when it is 1 point, and "moderately" when it is 0 point. Invalid ". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.

Sensory test (bare skin effect test) Female subjects complaining of rough skin, fine wrinkles, dry skin, etc.
The sample was applied twice a day (morning and evening) to 20 persons (55 years old) for 3 consecutive months, and the effect after 1, 2, and 3 months was evaluated. In the test results, for each item of skin wettability, smoothness, and elasticity, the respondents answered that "skin was moistened", "skin became smooth", and "skin became taut" Indicated by the number of people.

Examples 1 to 8 and Comparative Examples 1 to 7 [Skin cream] γ-amino-β-hydroxybutyric acid and its salt, and assembly extract and / or carrot extract are mixed as shown in Tables 4 and 5. (In terms of dry residue, the same applies hereinafter), a skin cream was prepared with the composition shown in Table 3 below, and the above-described experiments were performed. Note that γ-amino-β-hydroxybutyric acid is GAB
As the salts of OB and γ-aminobutyric acid-β-hydroxybutyric acid, potassium salt is GABOB-K, and sodium salt is G
ABOB-N, its calcium salt is abbreviated as GABOB-C, and its magnesium salt is abbreviated as GABOB-M.

(1) Composition

[0028]

[Table 3]

(2) Preparation Method The components (A) and (B) were each dissolved by heating to 80 ° C., mixed, and cooled to 30 ° C. with stirring to prepare each skin cream.

(3) Characteristics Tables 4 to 6 show the results of various tests conducted on each skin cream. As shown in Tables 4 to 6, the assembly extract, carrot extract, or γ-amino-β- of Comparative Examples 1 to 7 were used.
A skin cream containing only hydroxybutyric acid and its salt alone did not provide sufficient effects in various properties, and the assembly extract and / or carrot extract of Examples 1 to 8 of the present invention and γ-amino-β- A skin cream containing at least one selected from the group consisting of hydroxybutyric acid and salts thereof has a remarkable effect on various properties, and in a sensory test, showed an excellent skin effect 1 to 2 months after application of the sample. .

[0031]

[Table 4]

[0032]

[Table 5]

[0033]

[Table 6]

Examples 9 to 11 [Skin Lotion] Skin lotions were prepared according to the compositions shown in Table 7, and various tests were carried out.

(1) Composition

[0036]

[Table 7]

(2) Preparation method After the components (A) and (B) were uniformly dissolved, the components (A) and (B) were mixed, dispersed by stirring, and then charged into a container. At the time of use, the contents were uniformly shaken and used.

(3) Characteristics Examples 9 to 11 all showed good results in the above tests.

[0039]

As described above, the present invention provides a useful skin aging preventive cosmetic composition having excellent skin aging preventing effects (rough skin improving effect, keratin improving effect, effect of increasing turnover speed, beautiful skin effect, etc.). It is clear to offer.

Claims (1)

(57) [Claims] An anti-aging skin cosmetic comprising at least one member selected from the group consisting of γ-amino-β-hydroxybutyric acid and a salt thereof, and an assembly extract and / or a carrot extract.