JP3192217B2 - Medical tubing - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical tube used for blood transfusion, transfusion, etc., which can always set a stable flow rate.

[0002]

2. Description of the Related Art Conventionally, a tube made of vinyl chloride has been used for blood transfusion or infusion. However, when a highly lipid-soluble drug such as nitroglycerin is contained in an infusion solution, the drug adsorbs to the inner wall of the tube. For example, the set amount of medicine may not be supplied to the human body.

[0003] For this reason, a tube using a polyolefin resin having high hydrophobicity has been used in order to make it difficult for drug adsorption to occur.

[0004] However, when the hydrophobicity of the tube is increased, the wettability is deteriorated, and once the air bubbles adhere, there have been problems such as difficulty in removing the air bubbles.

[0005] For example, in the priming operation, care must be taken to prevent air bubbles from adhering to the inside of the tube, and once it adheres to the inner wall of the tube, it sometimes takes time to remove it.

Further, when the flow rate is adjusted by using a clamp or the like, the tube is deformed, and the flow path is extremely narrow. In the vicinity where the flow path is narrowing, air bubbles are particularly likely to adhere. Therefore, even if the flow rate is accurately adjusted by using a clamp, if air bubbles adhere to that portion, the flow may be obstructed and the flow rate may change. there were.

[0007] For this purpose, a process has been developed in which a hydrophilic substance such as a surfactant is coated on the inner wall of a hydrophobic tube by dipping in a solution thereof and drying the coating to increase wettability. .

[0008]

However, when coated on the inner wall of the tube, there is a possibility that the coated hydrophilic substance may be eluted, and furthermore, the coating process becomes complicated and mass production is not possible, and improvement is desired. Was rare. In addition, if the infusion is continued for a long time, the wettability may change with time because the coating peels off.

[0009]

DISCLOSURE OF THE INVENTION An object of the present invention is to make it easy to manufacture, and there is no danger of generation of elutes, and it is difficult for air bubbles to adhere to the inner wall, or even if they adhere, they are easily desorbed. It is to provide a medical tube that can be used.

[0010]

This and other objects are achieved by the invention described hereinafter. That is, 1,2-
This is achieved by a medical tube comprising 100 parts by weight of polybutadiene and 0.02 to 5.0 parts by weight of a fatty acid ester-based nonionic surfactant.

[0011]

According to the present invention, a fatty acid ester-based nonionic surfactant is added in an amount of 0.02 to 100 parts by weight of 1,2-polybutadiene.
Is 5.0 parts by weight, the wettability of the inner wall of the tube is increased due to the effect of the surfactant incorporated in the resin serving as the base material. It is difficult to remove even if it adheres. Further, since a fatty acid ester-based nonionic surfactant is blended with 1,2-polybutadiene, elution is unlikely to occur, and there is little change in the inner surface of the tube over time.

The nonionic surfactants of the fatty acid ester type used in the present invention include fatty acid esters of glycerin such as glycerin monostearate, glycerin monolaurate, glycerin monooleate and glycerin monopalmitate; Fatty acid esters of propylene glycol such as laurate, propylene glycol monostearate, propylene glycol monooleate, and propylene monopalmitate; fatty acid esters of sorbitan such as sorbitan monolaurate, sorbitan monostearate, sorbitan monooleate, and sorbitan palmitate There is. These surfactants are highly miscible with olefin resins because of their high lipophilicity.

The amount of the fatty acid ester nonionic surfactant used in the present invention is 0.02 to 5.0 parts by weight based on 100 parts by weight of 1,2-polybutadiene.
Preferably it is 0.03-4.0 parts by weight. If the amount is less than 0.02 parts by weight, the wettability of the inner wall of the tube is poor, and if it exceeds 5.0 parts by weight, the surfactant may be eluted into the infusion solution, which is not preferable.

[0014]

Further, a laminated structure having the resin of the tube of the present invention inside may be adopted. At that time, the thickness of the resin serving as the inner wall can be appropriately changed depending on the required flexibility and the like.

[0016] The medical tube of the present invention comprises 1,2-
After blending a fatty acid ester-based nonionic surfactant with 100 parts by weight of polybutadiene, extrusion molding, which is a generally known method for producing a tube, can be applied.

[0017]

【Example】

[0018]

Examples 1-3: 1.2-polybutadiene (RB81
0, manufactured by Nippon Synthetic Rubber Co., Ltd.) and glycerin monostearate (Riquemar, manufactured by Rika Vitamin Co., Ltd.) according to the compounding amounts shown in Table 1. The inner diameter was 2.1 m using an extruder.
A tube having an outer diameter of 3.1 mm was prepared.

[0019]

Comparative Example 1 A tube was prepared from the same 1.2-polybutadiene used in the examples by the same method as in the examples.

[0020]

[Table 1]

[Experimental Example] The tubes prepared in Examples 1 to 3 and Comparative Example 1 were cut to a length of 2 m, a drip tube with a bottle needle was attached to one end, and a clamp was set near the center of the tube. A puncture needle was connected to the end, and a bottle needle was pierced into the drug solution outlet of the infusion bag to introduce the infusion solution into the tube. The infusion bag is suspended at a high place, and the flow rate is adjusted by creme while observing the amount of dripping in the drip tube (the number of drippings per unit time, when about 60 drops are dropped per minute, it becomes 60 ml per hour). Was. About one hour later, the rate of change (the following equation) when the flow rate was observed again was observed.
Table 2 shows the results. From Table 2, it can be seen that the tubes of Examples 1 to 3 have almost no change in the flow rate.

Rate of change (%) = 100 × (flow rate after 1 hour) − (initial flow rate (60 ml / hour)) ÷ (initial flow rate (60 ml / hour)) Also, the result of visual observation of the tube No air bubbles were observed on the tube of the example, but air bubbles were observed on the tube of Comparative Example 1 near the clamp.

[0023]

[Table 2]

[Test Example] The tubes prepared in Examples 1 to 3 and Comparative Example 1 were subjected to a safety test according to the pharmacy method. Table 3 shows the results.

[0025]

[0026]

[Table 3]

Further, when the infusion solution that was flowed in the experimental examples of Examples 1 to 3 was analyzed, almost no surfactant was detected.

[0028]

The present invention relates to 1,2-polybutadiene 100
This is a medical tube in which 0.02 to 5.0 parts by weight of a fatty acid ester-based nonionic surfactant is blended in parts by weight, and the surfactant is blended in 1,2-polybutadiene. In addition, the wettability of the inner wall of the tube is improved as compared with the case where the tube is not blended, and even if air bubbles adhere during blood transfusion or transfusion, the tube can be easily removed. further,
Even when the flow rate is adjusted by the clamp, no air bubbles adhere to the flow path, and a stable flow rate can be secured without a change in the flow rate. Further, it has the same effect of preventing air bubble adhesion as the coated one, and has the advantage that there is no fear that the surfactant is eluted.

Claims (3)

(57) [Claims] 1. A fatty acid ester-based nonionic surfactant is used in an amount of 0.02 to 100 parts by weight of 1,2-polybutadiene.
A medical tube made of a resin mixed with 5.0 parts by weight. 2. The medical tube according to claim 1, wherein the amount of the fatty acid ester-based nonionic surfactant is 0.03 to 4.0 parts by weight. 3. The medical tube according to claim 1, wherein the fatty acid ester nonionic surfactant is glycerin monostearate.