JP2710663B2 - Blood processing device manufacturing method - Google Patents
Blood processing device manufacturing methodInfo
- Publication number
- JP2710663B2 JP2710663B2 JP1088099A JP8809989A JP2710663B2 JP 2710663 B2 JP2710663 B2 JP 2710663B2 JP 1088099 A JP1088099 A JP 1088099A JP 8809989 A JP8809989 A JP 8809989A JP 2710663 B2 JP2710663 B2 JP 2710663B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- hollow fiber
- processing apparatus
- gas
- blood processing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Description
【発明の詳細な説明】 ＜産業上の利用分野＞ 本発明は、血液透析，血液過，血漿分離などの中空
繊維半透膜を用いる血液処理器の製造方法に関する。Description: TECHNICAL FIELD The present invention relates to a method for producing a blood processor using a hollow fiber semi-permeable membrane such as hemodialysis, blood perfusion, and plasma separation.
＜従来技術＞ 血液処理器は、血液を血液処理器に流す前処理とし
て、生理食塩水を血液処理器にプライミングが行なわ
れ、血液処理器に完全に生理食塩水に置換し、その際充
分に生理食塩水を流して血液処理器内の洗浄も同時に行
なわれる。これらの血液処理器のプライミングにおい
て、血液処理器の中空繊維半透膜への生理食塩水が問題
となる。<Prior art> In a blood processing apparatus, as a pretreatment for flowing blood to the blood processing apparatus, priming is performed on the blood processing apparatus, and the blood processing apparatus completely replaces the blood processing apparatus with the physiological saline. Washing of the inside of the blood processor by flowing physiological saline is also performed at the same time. In the priming of these blood processing devices, physiological saline solution to the hollow fiber semipermeable membrane of the blood processing device becomes a problem.
すなわち、中空繊維半透膜への生理食塩水の充填が完
全に行なわれないとプライミング時の中空繊維の洗浄効
果が悪いのみならず血流を流した時に中空繊維部で血流
のクロットを誘発したり、使用後の返血過程で血液が処
理器に残血する等の問題が発生する。In other words, if the hollow fiber semi-permeable membrane is not completely filled with physiological saline, not only is the cleaning effect of the hollow fiber at the time of priming poor, but also a blood flow clot is induced at the hollow fiber portion when the blood flow flows. This causes problems such as dripping and blood remaining in the processor during the blood return process after use.
従って、生理食塩水の充填性は、病院におけるプライ
ミング作業の効率、さらには、使用時の安全性に影響す
る特性であり、充填性の優れた血液処理器が要求されて
いる。Therefore, the filling property of physiological saline is a characteristic that affects the efficiency of priming work in hospitals, and furthermore, the safety at the time of use, and there is a demand for a blood processing apparatus with excellent filling properties.
＜発明の目的＞ 本発明者は、かかる従来の問題点を解決することを目
的として、鋭意研究した結果、中空繊維半透膜を血液処
理器に樹脂で固定し再端部を開口させた後、他方より圧
空を流すことが中空繊維半透膜への生理食塩水の充填性
改善に効率なことを見い出し、本発明に到達した。<Object of the Invention> The present inventor has conducted intensive studies with the aim of solving such a conventional problem. As a result, after fixing the hollow fiber semipermeable membrane to the blood processing apparatus with resin and opening the re-end portion, On the other hand, it has been found that flowing compressed air from the other side is effective for improving the filling property of the physiological saline into the hollow fiber semi-permeable membrane, and has reached the present invention.
＜発明の構成＞ 本発明は、以下に示す血液処理器の製造方法を提供す
るものである。<Constitution of the Invention> The present invention provides a method for manufacturing a blood processing apparatus described below.
（１）中空繊維状半透膜を構成部材とする血液処理器の
製造方法において、可塑剤を付着せしめた状態で実質的
に乾燥状態とした該中空繊維状半透膜の集束体を筒状容
器に装填せしめ、その両端を樹脂によりシール固定した
後、両端を切断して該中空繊維の中空部を開口せしめ、
該開部の一方側から該中空繊維の中空部に気体を流通せ
しめて該中空部に存在する過剰の可塑剤を除去すること
を特徴とする血液処理器の製造方法。(1) In a method for manufacturing a blood processing apparatus including a hollow fiber-like semipermeable membrane as a constituent member, the hollow fiber-like semipermeable membrane bundled in a substantially dry state with a plasticizer attached is formed in a cylindrical shape. After loading in a container and sealing and fixing both ends thereof with a resin, both ends are cut to open the hollow portion of the hollow fiber,
A method for producing a blood processing apparatus, comprising: flowing gas from one side of the opening to the hollow portion of the hollow fiber to remove excess plasticizer present in the hollow portion.
（２）該中空繊維状半透膜がセルロース系高分子重合体
を主体としたものである請求項１の血液処理器の製造方
法。(2) The method for producing a blood processing apparatus according to claim 1, wherein the hollow fiber-like semipermeable membrane is mainly composed of a cellulosic polymer.
（３）該セルロース系高分子重合体が、セルロースアセ
テート又は再生セルロースである請求項２の血液処理器
の製造方法。(3) The method for producing a blood processing apparatus according to claim 2, wherein the cellulose-based polymer is cellulose acetate or regenerated cellulose.
（４）該切断工程と該気体の流通工程の間に、又は該気
体の流通工程の後に、該筒状容器の一端に血液分配部材
を、他端に血液収集部材を具備せしめる請求項１〜３の
いずれかの血液処理器の製造方法。(4) A blood distribution member is provided at one end of the cylindrical container and a blood collection member is provided at the other end between the cutting step and the gas circulation step or after the gas circulation step. 3. The method for manufacturing a blood processor according to any one of the above items 3.
（５）該実質的に乾燥状態とした中空繊維状半透膜が50
〜150重量％の範囲で可塑剤を含有するものである請求
項１〜４のいずれかに記載の血液処理器の製造方法。(5) The hollow fiber-like semi-permeable membrane in a substantially dry state has 50
The method for producing a blood processing apparatus according to any one of claims 1 to 4, wherein the method comprises a plasticizer in an amount of from 150 to 150% by weight.
（６）該可塑剤が、グリセリン、エチレングリコール，
ジエチレングリコール及びポリエチレングリコールの群
から選ばれる少なくとも一種である請求項の５の血液処
理器の製造方法。(6) The plasticizer is glycerin, ethylene glycol,
6. The method for producing a blood processing apparatus according to claim 5, wherein the method is at least one selected from the group consisting of diethylene glycol and polyethylene glycol.
（７）該気体の流通工程において、気体の流速が0.2〜1
0m/sec、流通時間が１〜10分である請求項１〜６のいず
れかに記載の血液処理器の製造方法。(7) In the gas flow step, the gas flow rate is 0.2 to 1
The method according to any one of claims 1 to 6, wherein the flow time is 0 m / sec and the flow time is 1 to 10 minutes.
（８）該気体の流通工程における該気体が空気である請
求項１〜７のいずれかの血液処理器の製造方法。(8) The method according to any one of claims 1 to 7, wherein the gas in the gas distribution step is air.
（９）該血液処理器が血液透析器である請求項１〜８の
いずれかの血液処理器の製造方法。(9) The method for producing a blood processor according to any one of claims 1 to 8, wherein the blood processor is a hemodialyzer.
以下本発明についてさらに詳細に説明する。Hereinafter, the present invention will be described in more detail.
本発明において中空繊維半透膜に可塑剤を付着せし
め、且つ実質的に乾燥状態にする方法としては、特に限
定されるものでなく、例えば所定濃度に可塑剤を溶解し
た水溶液を中空繊維半透膜に付着させ余分の水溶液をエ
アーナイフで取り除いた後、熱風中で十分乾燥する方法
があげられる。In the present invention, the method of adhering the plasticizer to the hollow fiber semipermeable membrane and making it substantially dry is not particularly limited. For example, an aqueous solution in which the plasticizer is dissolved at a predetermined concentration may be used. After removing the excess aqueous solution by adhering to the film with an air knife, a method of sufficiently drying in hot air can be used.
例えばセルロースジアセテートの可塑化溶融紡糸性に
よる血液透析用の中空繊維半透膜の場合にには、セルロ
ースジアセテートの重量に対して、可塑剤が50〜150重
量％の範囲で付着された状態で実質上乾燥した後に、血
液処理器用の筒状容器内に、中空繊維半透膜の集束体と
して装填し、通常の方法によって両端がウレタン樹脂や
エポキシ樹脂等の樹脂を用いて遠心成型等によりシール
固定された後、その両端を中空糸を固定した樹脂と共に
切断して、中空繊維の中空部を開口させ、一方より気体
を中空繊維半透膜へ圧入して、中空繊維半透膜内に流す
ことにより中空繊維半透膜の内壁部に付着している過剰
の可塑剤を取り除くことにより血液処理器の生理食塩水
の充填性を改善する。For example, in the case of a hollow fiber semipermeable membrane for hemodialysis by plasticizing melt spinnability of cellulose diacetate, a state in which a plasticizer is attached in a range of 50 to 150% by weight based on the weight of cellulose diacetate. After substantially drying in a cylindrical container for a blood processing device, the hollow fiber semi-permeable membrane is charged as a bundle, and both ends are centrifugally molded using a resin such as a urethane resin or an epoxy resin by a usual method. After the seal is fixed, both ends are cut together with the resin fixing the hollow fiber, the hollow portion of the hollow fiber is opened, and gas is pressed into the hollow fiber semi-permeable membrane from one side, into the hollow fiber semi-permeable membrane. By flowing, the excess plasticizer adhering to the inner wall of the hollow fiber semipermeable membrane is removed, thereby improving the filling property of the physiological saline in the blood processor.
この場合の中空繊維半透膜内を流す気体の流速は、0.
2m/sec〜10m/sec気体の流通時間は１分〜10分が好まし
い。In this case, the flow velocity of the gas flowing through the hollow fiber semipermeable membrane is 0.
The flow time of the gas of 2 m / sec to 10 m / sec is preferably 1 minute to 10 minutes.
かかる範囲であれば、中空繊維半透膜内壁の過剰に付
着している可塑剤を取除くことが出来る。Within such a range, the excessively adherent plasticizer on the inner wall of the hollow fiber semipermeable membrane can be removed.
気体の流通速度が0.2m/sec未満であると、中空繊維半
透膜内壁部に付着した過剰の可塑剤を取り除く効果が少
なく、好ましくない、又、10m/secを超えると気体の使
用量が多く経済的にも好ましくない。一方、流通時間に
ついては、１分〜10分が好ましい、１分未満までは可塑
剤の除去が十分に行なわれず好ましくない。10分を超え
ると気体の使用量が多く経済的にも好ましくない。When the gas flow rate is less than 0.2 m / sec, the effect of removing excess plasticizer attached to the inner wall of the hollow fiber semipermeable membrane is small, which is not preferable, and when the gas flow rate exceeds 10 m / sec, the amount of gas used is reduced. It is not economically desirable. On the other hand, the circulation time is preferably from 1 minute to 10 minutes, and if it is less than 1 minute, the plasticizer is not sufficiently removed, which is not preferable. If it exceeds 10 minutes, the amount of gas used is large, which is not economically preferable.
＜実施例＞ 以下に本発明の実施例と比較例と共に示すが、本発明
は、それらによって何ら限定されるものでない。セルロ
ースジアセテートをポリエチレングリコールと共に可塑
化溶融により紡糸して得られた血液透析用中空繊維半透
膜の集束体に、グリセリンを含有した水溶液を付着せし
めた後エアーナイフにより過剰に付着した水溶液を除去
し熱風中で乾燥することによりセルロースジアセテート
中空繊維半透膜の集束体を得た。<Examples> Hereinafter, examples of the present invention and comparative examples are shown, but the present invention is not limited thereto. An aqueous solution containing glycerin is applied to the bundle of the hollow fiber semipermeable membrane for hemodialysis obtained by plasticizing and spinning cellulose diacetate together with polyethylene glycol, and then the excess aqueous solution is removed with an air knife. After drying in hot air, a bundle of cellulose diacetate hollow fiber semipermeable membrane was obtained.
かかる集束体を常法に従って筒状容器に装填し両端を
ウレタン樹脂により遠心成型後に切断し、分配板等のヘ
ッダー部材を固着させて、血液透析器を組み立てた、一
方のヘッダーより、圧空をを吹込み、中空繊維半透膜内
での圧空の流速を０〜10m/sec圧空処理時間を０〜10分
の条件で中空繊維半透膜に圧空を流した。Such a bundle is loaded into a cylindrical container according to a conventional method, and both ends are cut after centrifugal molding with urethane resin, a header member such as a distribution plate is fixed, and a hemodialyzer is assembled. The air was blown into the hollow fiber semi-permeable membrane under the condition that the flow rate of the compressed air in the hollow fiber semi-permeable membrane was 0 to 10 m / sec and the pressure processing time was 0 to 10 minutes.
圧空処理後に、血液処理器を立てた状態で固定し下側
より、生理食塩水１をヘッド圧力50g/cm2・Ｇで導入
して血液透析器内に充填を行なった後、血液透析器の外
面より生理食塩水の充填されていない中空繊維半透膜の
本数を測定したところ、表Ｉのような結果が得られた。After the air pressure treatment, the blood processor is fixed in an upright state, physiological saline 1 is introduced from the lower side at a head pressure of 50 g / cm 2 · G, and the inside of the hemodialyzer is filled. The number of hollow fiber semipermeable membranes not filled with physiological saline was measured from the outer surface, and the results shown in Table I were obtained.
＜発明の効果＞ 本発明の血液処理器の製造方法によれば、プライミン
グ性の良好な血液処理器の製造することが可能になり、
残血の少ないより安全な血液処理器を提供することがで
きる。 <Effect of the Invention> According to the method for manufacturing a blood processing apparatus of the present invention, it is possible to manufacture a blood processing apparatus having good priming properties,
A safer blood processor with less residual blood can be provided.
Claims (9)
理器の製造方法において、可塑剤を付着せしめた状態で
実質的に乾燥状態とした該中空繊維状半透膜の集束体を
筒状容器に装填せしめ、その両端を樹脂によりシール固
定した後、両端を切断して該中空繊維の中空部を開口せ
しめ、該開部の一方側から該中空繊維の中空部に気体を
流通せしめて該中空部に存在する過剰の可塑剤を除去す
ることを特徴とする血液処理器の製造方法。1. A method for manufacturing a blood processing apparatus comprising a hollow fiber semipermeable membrane as a constituent member, wherein a bundle of the hollow fibrous semipermeable membrane which is substantially dried with a plasticizer attached thereto is provided. After being charged into a cylindrical container, and both ends thereof are sealed and fixed with a resin, both ends are cut to open the hollow portion of the hollow fiber, and gas is passed from one side of the open portion to the hollow portion of the hollow fiber. Removing the excess plasticizer present in the hollow portion by using the method.
重合体を主体としたものである請求項１の血液処理器の
製造方法。2. The method according to claim 1, wherein the hollow fiber semipermeable membrane is mainly composed of a cellulosic polymer.
スアセテート又は再生セルロースである請求項２の血液
処理器の製造方法。3. The method according to claim 2, wherein the cellulosic polymer is cellulose acetate or regenerated cellulose.
は該気体の流通工程の後に、該筒状容器の一端に血液分
配部材を、他端に血液収集部材を具備せしめる請求項１
〜３のいずれかの血液処理器の製造方法。4. A blood distribution member is provided at one end of the cylindrical container and a blood collection member is provided at the other end between the cutting step and the gas flowing step or after the gas flowing step. 1
3. The method for producing a blood processing apparatus according to any one of items 1 to 3.
膜が50〜150重量％の範囲で可塑剤を含有するものであ
る請求項１〜４のいずれかに記載の血液処理器の製造方
法。5. The blood processor according to claim 1, wherein the hollow fiber-like semipermeable membrane in a substantially dry state contains a plasticizer in a range of 50 to 150% by weight. Manufacturing method.
ール、ジエチレングリコール及びポリエチレングリコー
ルの群から選ばれる少なくとも一種である請求項の５の
血液処理器の製造方法。6. The method according to claim 5, wherein said plasticizer is at least one selected from the group consisting of glycerin, ethylene glycol, diethylene glycol and polyethylene glycol.
0.2〜10m/sec、流通時間が１〜10分である請求項１〜６
のいずれかに記載の血液処理器の製造方法。7. The method according to claim 7, wherein the flow rate of the gas is
0.2 to 10 m / sec, circulation time is 1 to 10 minutes.
The method for producing a blood processor according to any one of the above.
ある請求項１〜７のいずれかの血液処理器の製造方法。8. The method for producing a blood processing apparatus according to claim 1, wherein said gas in said gas distribution step is air.
〜８のいずれかの血液処理器の製造方法。9. The blood treatment device according to claim 1, wherein said blood treatment device is a hemodialyzer.
9. The method for producing a blood processing apparatus according to any one of items 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1088099A JP2710663B2 (en) | 1989-04-10 | 1989-04-10 | Blood processing device manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1088099A JP2710663B2 (en) | 1989-04-10 | 1989-04-10 | Blood processing device manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02268767A JPH02268767A (en) | 1990-11-02 |
| JP2710663B2 true JP2710663B2 (en) | 1998-02-10 |
Family
ID=13933422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1088099A Expired - Fee Related JP2710663B2 (en) | 1989-04-10 | 1989-04-10 | Blood processing device manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2710663B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995024262A1 (en) * | 1994-03-08 | 1995-09-14 | Teijin Limited | Hollow-fiber blood-purifying membrane and process for producing the same |
| JP2003053156A (en) * | 2001-08-17 | 2003-02-25 | Kawasumi Lab Inc | Dialysis module and manufacturing method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5438927A (en) * | 1977-08-31 | 1979-03-24 | Senko Med Instr Mfg | Treating of hollow yarn |
| JPS56136567A (en) * | 1980-03-28 | 1981-10-24 | Terumo Corp | Method and apparatus for washing hollow thread type blood dialyzer |
| JPS59225066A (en) * | 1983-06-03 | 1984-12-18 | テルモ株式会社 | Production of blood treating apparatus |
-
1989
- 1989-04-10 JP JP1088099A patent/JP2710663B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02268767A (en) | 1990-11-02 |
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