JP2756581B2 - Ion source for liquid chromatography mass spectrometer - Google Patents
Ion source for liquid chromatography mass spectrometerInfo
- Publication number
- JP2756581B2 JP2756581B2 JP1120647A JP12064789A JP2756581B2 JP 2756581 B2 JP2756581 B2 JP 2756581B2 JP 1120647 A JP1120647 A JP 1120647A JP 12064789 A JP12064789 A JP 12064789A JP 2756581 B2 JP2756581 B2 JP 2756581B2
- Authority
- JP
- Japan
- Prior art keywords
- orifice plate
- hole
- small
- diameter hole
- atmospheric pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004811 liquid chromatography Methods 0.000 title claims description 10
- 239000007788 liquid Substances 0.000 claims description 18
- 239000012212 insulator Substances 0.000 claims description 10
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 description 31
- 239000007789 gas Substances 0.000 description 21
- 239000012159 carrier gas Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- 238000004807 desolvation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Sources, Ion Sources (AREA)
Description
【発明の詳細な説明】 （産業上の利用分野） この発明は液体クロマトグラフィ質量分析計用イオン
源に関するものである。Description: TECHNICAL FIELD The present invention relates to an ion source for a liquid chromatography mass spectrometer.
（従来の技術） 従来のこの種のイオン源は第３図に示されている（特
公昭62-57068号公報参照）。同図によれば、液体クロマ
トグラフ１より流出した液体試料は中空針電極２の内部
の貫通穴を通ってから、中空針電極２の先端より放電室
５に導入されている。一方、キャリアガス３は中空針電
極２の外周に設けられ、先端を細くし、中空針電極２の
先端との間に隙間を有する案内管４と、中空針電極２と
の間の隙間よりジェット流として放電室５に放出され
る。中空針電極２と、イオン通過口6aを有する対向電極
６との間に高圧電源７により高電圧が印加され、この高
電圧によってコロナ放電が発生する。なお、図におい
て、８は加速電極、９はアース電極、10はガス出口であ
る。(Prior Art) A conventional ion source of this kind is shown in FIG. 3 (see Japanese Patent Publication No. Sho 62-57068). According to the figure, the liquid sample flowing out of the liquid chromatograph 1 passes through a through hole inside the hollow needle electrode 2 and is introduced into the discharge chamber 5 from the tip of the hollow needle electrode 2. On the other hand, the carrier gas 3 is provided on the outer periphery of the hollow needle electrode 2, has a narrow tip, and is jetted from a gap between the guide tube 4 having a gap between the hollow needle electrode 2 and the hollow needle electrode 2. It is discharged into the discharge chamber 5 as a flow. A high voltage is applied between the hollow needle electrode 2 and the counter electrode 6 having the ion passage port 6a by a high voltage power supply 7, and a corona discharge is generated by the high voltage. In the figure, 8 is an acceleration electrode, 9 is a ground electrode, and 10 is a gas outlet.
したがって、上記液体クロマトグラフィ質量分析計用
イオン源において、中空針電極２の先端より噴出された
液体試料は、まず、コロナ放電によって微細化される
が、案内管４と、中空針電極２との間の隙間を流れるキ
ャリアガス３のジェット流により更に微細化され、そし
て、コロナ放電の熱によって気化されて、イオン化が促
進されるようになる。Therefore, in the ion source for liquid chromatography mass spectrometer, the liquid sample ejected from the tip of the hollow needle electrode 2 is first miniaturized by corona discharge. Is further refined by the jet flow of the carrier gas 3 flowing through the gap, and is vaporized by the heat of the corona discharge to promote ionization.
（発明が解決しようとする課題） 従来の液体クロマトグラフィ質量分析計用イオン源
は、コロナ放電によって微細化された液体試料が、キャ
リアガス３のジェット流によって更に微細化されるが、
微細化された液体試料の粒滴がキャリアガスのジェット
流によって対向電極６と衝突し、対向電極６上で気化
し、結晶化するため、対向電極６の通過口6aにおいて、
目詰まりが起きる問題があった。また、キャリアガス３
のために案内管４内の圧力が放電室５に比べて高圧力に
なった場合、キャリアガス３を放電室５に放出する際、
断熱膨張が生じ、クラスタイオンが生成して、イオン源
の性能が低下する問題があった。更に、対向電極６のイ
オン通過口6aを通ったイオンは加速電極８によって引き
出されるが、引き出されたイオンの拡散を抑制する手段
がなされていなかったから、イオンの補集効率が悪くな
る問題もあった。(Problems to be Solved by the Invention) In a conventional ion source for a liquid chromatography mass spectrometer, a liquid sample miniaturized by corona discharge is further miniaturized by a jet flow of a carrier gas 3.
The droplets of the micronized liquid sample collide with the counter electrode 6 by the jet flow of the carrier gas, and are vaporized and crystallized on the counter electrode 6, so that at the passage 6a of the counter electrode 6,
There was a problem of clogging. In addition, carrier gas 3
When the carrier gas 3 is discharged into the discharge chamber 5 when the pressure in the guide tube 4 becomes higher than that in the discharge chamber 5 due to
There is a problem that adiabatic expansion occurs, cluster ions are generated, and the performance of the ion source is reduced. Further, ions passing through the ion passage opening 6a of the counter electrode 6 are extracted by the accelerating electrode 8, but since there is no means for suppressing the diffusion of the extracted ions, there is a problem that the ion collection efficiency is deteriorated. Was.
この発明の目的は、従来の上記問題を解決して、イオ
ン通過口での目詰まりを防止すると共に、イオンの補集
効率等を良くして、性能を向上させることである。SUMMARY OF THE INVENTION An object of the present invention is to solve the conventional problems described above, prevent clogging in an ion passage port, improve ion collection efficiency, and improve performance.
（課題を解決するための手段） 上記目的を達成するために、この発明の液体クロマト
グラフィ質量分析計用イオン源は、筒状体、該筒状体の
天部の開口に絶縁体を介して取付けた貫通穴付の天板、
および該筒状体の底部の開口に絶縁体を介して取付けた
小径穴付のオリフィス板で囲むように形成された大気圧
イオン化室と、上記天板の貫通穴内を、間隙を保って貫
通しながら上記オリフィス板の小径穴と同軸上に配設さ
れ、先端が上記大気圧イオン化室内で上記オリフィス板
の小径穴と距離をおいて対向する液体試料の流れる中空
針電極と、上記オリフィス板の小径穴と中空針電極の先
端との間に向けられた噴出口より高温の乾燥ガスを噴出
する少なくとも２つ以上のガス供給管と、上記オリフィ
ス板の上記大気圧イオン化室と反対側部で上記オリフィ
ス板の小径穴と同軸上に配設された網状の筒状電極と、
該筒状電極の上記オリフィス板と反対側の近傍で上記オ
リフィス板の小径穴と同軸上に配設された穴をもつスキ
マーとを備えたことを特徴とするものである。(Means for Solving the Problems) In order to achieve the above object, an ion source for a liquid chromatography mass spectrometer according to the present invention is attached to a cylindrical body and an opening at the top of the cylindrical body via an insulator. Top plate with through holes,
And an atmospheric pressure ionization chamber formed so as to be surrounded by an orifice plate with a small diameter hole attached to the opening at the bottom of the cylindrical body via an insulator, and penetrates through the through hole of the top plate with a gap kept therebetween. A hollow needle electrode through which the liquid sample flows, which is disposed coaxially with the small diameter hole of the orifice plate and whose tip faces the small diameter hole of the orifice plate in the atmospheric pressure ionization chamber at a distance, and the small diameter of the orifice plate. At least two or more gas supply pipes for ejecting hot dry gas from an ejection port directed between the hole and the tip of the hollow needle electrode; and the orifice at a side of the orifice plate opposite to the atmospheric pressure ionization chamber. A mesh-like cylindrical electrode arranged coaxially with the small diameter hole of the plate,
A skimmer having a hole disposed coaxially with a small diameter hole of the orifice plate in the vicinity of the cylindrical electrode on the side opposite to the orifice plate.
なお、筒状体の外周には加熱ヒータを配設し、大気圧
イオン化室内の温度を150℃程度に保っている。A heater is provided on the outer periphery of the cylindrical body, and the temperature in the atmospheric pressure ionization chamber is maintained at about 150 ° C.
（作用） この発明においては、中空針電極の先端とオリフィス
板の小径穴との距離を1cmにし、中空針電極に印加する
電圧を３〜7Kv、オリフィス板に印加する電圧を60〜65
V、天板を100Vにすると、中空針電極の先端より噴出さ
れる液体試料は、コロナ放電により、正に帯電した微小
液滴となり、オリフィス板の小径穴の方向に流れるが、
ガス供給管の噴出口より噴出した高温の乾燥ガスは、オ
リフィス板の小径穴と中空針電極の先端との空間に流れ
込み、上記微小液滴を乾燥して、イオンを生成した後、
流れ方向を変え、中空針電極の先端より天板の貫通穴方
向に中空針電極に沿って流れ、天板の貫通穴より大気圧
イオン化室外へと流出する。このことより、上記微小液
滴より気化した溶媒分子は効率よく大気圧イオン化室外
へ放出される。一方、大気圧イオン化室内で生成したイ
オンは、オリフィス板の小径穴を貫通した後、65Vの電
圧の印加された網状の筒状電極内を通るようになるが、
網状の筒状電極によりイオン化された液体試料の粒子の
拡散が抑制され、網状の筒状電極内の中央部を通るよう
になる。その後、網状の筒状電極内の中央部を通ったイ
オンは、スキマーの穴を通過するようになる。(Operation) In the present invention, the distance between the tip of the hollow needle electrode and the small diameter hole of the orifice plate is 1 cm, the voltage applied to the hollow needle electrode is 3 to 7 Kv, and the voltage applied to the orifice plate is 60 to 65.
V, when the top plate is set to 100 V, the liquid sample ejected from the tip of the hollow needle electrode becomes positively charged fine droplets by corona discharge and flows in the direction of the small diameter hole of the orifice plate.
The high-temperature dry gas spouted from the spout of the gas supply pipe flows into the space between the small-diameter hole of the orifice plate and the tip of the hollow needle electrode, and after drying the microdroplets to generate ions,
The flow direction is changed, flows along the hollow needle electrode from the tip of the hollow needle electrode in the direction of the through hole of the top plate, and flows out of the atmospheric pressure ionization chamber through the through hole of the top plate. As a result, the solvent molecules vaporized from the microdroplets are efficiently released outside the atmospheric pressure ionization chamber. On the other hand, ions generated in the atmospheric pressure ionization chamber pass through the small-diameter hole of the orifice plate, and then pass through the mesh-like cylindrical electrode to which a voltage of 65 V is applied.
The diffusion of the particles of the ionized liquid sample is suppressed by the reticulated tubular electrode, and the particles pass through the central portion in the reticulated tubular electrode. Thereafter, the ions that have passed through the central portion of the mesh-like cylindrical electrode pass through the holes of the skimmer.
（実施例） 以下、この発明の実施例について図面を参照しながら
説明する。(Example) Hereinafter, an example of the present invention will be described with reference to the drawings.
第１図はこの発明の実施例を用いた液体クロマトグラ
フィ質量分析計の概略構成を示しており、同図におい
て、11は筒状体、12は天板、12aは天板12の貫通穴、13
はオリフィス板、13aはオリフィス板13の小径穴、14は
大気圧イオン化室、15は中空針電極、16は高温の乾燥ガ
スを噴出するガス供給管、16aはガス供給管16の噴出
口、17は網状の筒状電極、18は図示するようにコーン状
の部材であるスキマー、18aはスキマー18の穴、19は加
熱ヒータ、20は第１チャンバー、21はスキマー取付用筒
体、22はスキマー取付用筒体21内に配設されたレンズ
系、23は第２チャンバー、24は質量分析計である。第２
図は第１図の要部である大気圧イオン化イオン源を示し
ており、同図において、筒状体11と、この筒状体11の天
部の開口に絶縁体24aを介して取付けた貫通穴12a付の天
板12と、筒状体11の底部の開口に絶縁体24bを介して取
付けた小径穴13a付のオリフィス板13とで囲んで大気圧
イオン化室14が形成されている。そして、液体試料の流
れる中空針電極15は天板12の貫通穴12a内を貫通しなが
らオリフィス板13の小径穴13aと同軸上に配設され、そ
の先端が大気圧イオン化室14内でオリフィス板13の小径
穴13aと距離をおいて対向している。また、高温の乾燥
ガスを噴出する２個のガス供給管16は天板12の貫通穴12
aを挟んで対象の位置で天板12をそれぞれ貫通して大気
圧イオン化室14内に延び、その先端部において中空針電
極15の軸線側に曲がり、噴出口16aがオリフィス板13の
小径穴13aと中空針電極15の先端との間に向けられてい
る。更に、網状の筒状電極17はオリフィス板13の大気圧
イオン化室14と反対側部で、絶縁体24cを介してオリフ
ィス板13の小径穴13aと同軸上に配設されている。筒状
電極17のオリフィス板13と反対側の近傍で、スキマー18
の穴18aがオリフィス板13の小径穴13aと同軸に配設され
ている。加熱ヒータ19は筒状体11の外周に配設され、大
気圧イオン化室14内を加温する。FIG. 1 shows a schematic configuration of a liquid chromatography mass spectrometer using an embodiment of the present invention. In FIG. 1, 11 is a cylindrical body, 12 is a top plate, 12a is a through hole of the top plate 12, 13
Is an orifice plate, 13a is a small-diameter hole of the orifice plate 13, 14 is an atmospheric pressure ionization chamber, 15 is a hollow needle electrode, 16 is a gas supply pipe for ejecting a high-temperature dry gas, 16a is an ejection port of the gas supply pipe 16, 17 Is a mesh-shaped cylindrical electrode, 18 is a skimmer which is a cone-shaped member as shown, 18a is a hole of the skimmer 18, 19 is a heater, 20 is a first chamber, 21 is a skimmer mounting cylinder, and 22 is a skimmer. A lens system disposed in the mounting cylinder 21, 23 is a second chamber, and 24 is a mass spectrometer. Second
The figure shows an atmospheric pressure ionization ion source which is a main part of FIG. 1. In FIG. 1, a cylindrical body 11 and a through-hole attached to an opening at the top of the cylindrical body 11 through an insulator 24a are shown. An atmospheric pressure ionization chamber 14 is formed by being surrounded by a top plate 12 having a hole 12a and an orifice plate 13 having a small diameter hole 13a attached to an opening at the bottom of the cylindrical body 11 via an insulator 24b. The hollow needle electrode 15 through which the liquid sample flows is disposed coaxially with the small-diameter hole 13a of the orifice plate 13 while penetrating through the through-hole 12a of the top plate 12, and the tip thereof is located within the orifice plate 14 in the atmospheric pressure ionization chamber 14. It faces 13 small diameter holes 13a with a distance. Further, two gas supply pipes 16 for ejecting high-temperature dry gas are provided in the through holes 12 of the top plate 12.
Each penetrates the top plate 12 at the target position across the a and extends into the atmospheric pressure ionization chamber 14, bends at the tip thereof toward the axis of the hollow needle electrode 15, and the ejection port 16 a is a small-diameter hole 13 a of the orifice plate 13. And the tip of the hollow needle electrode 15. Further, the reticulated cylindrical electrode 17 is disposed on the opposite side of the orifice plate 13 from the atmospheric pressure ionization chamber 14 and coaxially with the small-diameter hole 13a of the orifice plate 13 via an insulator 24c. In the vicinity of the cylindrical electrode 17 on the side opposite to the orifice plate 13, a skimmer 18 is provided.
The hole 18a is disposed coaxially with the small-diameter hole 13a of the orifice plate 13. The heater 19 is arranged on the outer periphery of the cylindrical body 11 and heats the inside of the atmospheric pressure ionization chamber 14.
したがって、中空針電極15の先端とオリフィス板13の
小径穴13aとの距離を1cmにし、中空針電極15に印加する
電圧を３〜7Kv、オリフィス板13に印加する電圧を60〜6
5V、天板を100Vにすると、中空針電極15の先端より噴出
される液体試料は、コロナ放電により、正に帯電した微
小液滴を形成して、オリフィス板13の小径穴13aの方向
に流れるが、ガス供給管16の噴出口16aより噴出した高
温の乾燥ガスは、オリフィス板13の小径穴13aと中空針
電極15の先端との空間に流れ込み、上記微小液滴を乾燥
して、イオンを生成した後、流れ方向を変え、中空針電
極15の先端より天板12の貫通穴12a方向に中空針電極15
に沿って流れ、天板12の貫通穴12aより大気圧イオン化
室14外へと流出する。このことにより、中空針電極15の
先端とオリフィス板13の小径穴13aとの空間の溶媒ガス
濃度が減少し、コロナ放電によって生成されるクラスタ
イオンの脱溶媒化が促進される。また、乾燥ガスの天板
12の貫通穴12a方向への流れに沿って、上記微小液滴を
乾燥により生成した溶媒分子も、大気圧イオン化室14外
へ放出される。一方、大気圧イオン化室14内で生成した
イオンは、オリフィス板13の小径穴13aを通過した後、6
5Vの電圧の印加された網状の筒状電極17内を通るように
なるが、網状の筒状電極17によりイオンの拡散が抑制さ
れ、網状の筒状電極17内の中央部を通るようになる。そ
の後、網状の筒状電極17内の中央部を通ったイオンは、
スキマー18の穴18aを通過してから、レンズ系22を通
り、そして質量分析計24に入射されるようになる。ま
た、加熱ヒータ19で筒状体11を加熱し、大気圧イオン化
室14内を150℃程度に保つと、中空針電極15の先端より
噴出される液体試料の液滴が促進され、イオン化が良好
になる。Therefore, the distance between the tip of the hollow needle electrode 15 and the small diameter hole 13a of the orifice plate 13 is set to 1 cm, the voltage applied to the hollow needle electrode 15 is 3 to 7 Kv, and the voltage applied to the orifice plate 13 is 60 to 6
When the top plate is set to 100 V and the top plate is set to 100 V, the liquid sample ejected from the tip of the hollow needle electrode 15 forms minute droplets positively charged by corona discharge and flows in the direction of the small-diameter hole 13 a of the orifice plate 13. However, the high-temperature dry gas spouted from the spout 16a of the gas supply pipe 16 flows into the space between the small-diameter hole 13a of the orifice plate 13 and the tip of the hollow needle electrode 15, and dries the microdroplets to form ions. After the generation, the flow direction is changed and the hollow needle electrode 15 is moved from the tip of the hollow needle electrode 15 in the direction of the through hole 12a of the top plate 12.
And flows out of the atmospheric pressure ionization chamber 14 through the through hole 12a of the top plate 12. As a result, the concentration of the solvent gas in the space between the tip of the hollow needle electrode 15 and the small-diameter hole 13a of the orifice plate 13 is reduced, and desolvation of cluster ions generated by corona discharge is promoted. Also, the top plate of dry gas
Along with the flow of the 12 in the direction of the through hole 12a, the solvent molecules generated by drying the microdroplets are also discharged out of the atmospheric pressure ionization chamber 14. On the other hand, ions generated in the atmospheric pressure ionization chamber 14 pass through the small-diameter hole 13a of the orifice plate 13, and
Although it passes through the reticulated tubular electrode 17 to which a voltage of 5 V is applied, diffusion of ions is suppressed by the reticulated tubular electrode 17, and passes through the central portion in the reticulated tubular electrode 17. . After that, the ions that have passed through the central portion of the reticulated cylindrical electrode 17 are
After passing through the hole 18a of the skimmer 18, it passes through the lens system 22 and enters the mass spectrometer 24. Further, when the cylindrical body 11 is heated by the heater 19 and the inside of the atmospheric pressure ionization chamber 14 is maintained at about 150 ° C., droplets of the liquid sample ejected from the tip of the hollow needle electrode 15 are promoted, and ionization is improved. become.
ところで、上記実施例では２個のガス供給管16が使用
されているが、その数は２個以上であってもよい。ま
た、筒状体11の形状は円形に限らず、方形等の多角形で
あってもよい。In the above embodiment, two gas supply pipes 16 are used, but the number may be two or more. The shape of the cylindrical body 11 is not limited to a circle, but may be a polygon such as a square.
（発明の効果） この発明によれば、次のような効果が奏される。(Effects of the Invention) According to the present invention, the following effects can be obtained.
（１） ガス供給管の噴出口より噴出した高温の乾燥ガ
スが液体試料の正に帯電した微小液滴を乾燥して、イオ
ンを生成した後、流れ方向を変え、中空針電極の先端よ
り天板の貫通穴方向に中空針電極に沿って流れ、天板の
貫通穴より大気圧イオン化室外へと流出するようになる
ので、液体試料の液滴がオリフィス板上で気化すること
がなくなり、オリフィス板の小径穴を目詰まりさせるこ
とがなくなる。また、大気圧イオン化室内での乾燥ガス
の流れにより、数100μl/minの液体試料を完全に中空針
電極とオリフィス板との間の空間で気化できるようにな
り、その際、イオン源内の汚染もなく、長時間の連続使
用に耐えられるようになった。更に、乾燥ガスの流れに
沿って、微小液滴の乾燥により生成する溶媒分子が効率
よく大気圧イオン化室外に放出されることにより、微小
液滴の乾燥により生成したクラスタイオンの脱溶媒化を
促進し、分析感度を向上する。(1) A high-temperature dry gas spouted from the spout of the gas supply pipe dries positively charged microdroplets of the liquid sample, generates ions, changes the flow direction, and changes the flow direction from the tip of the hollow needle electrode. The liquid flows along the hollow needle electrode in the direction of the through hole of the plate and flows out of the atmospheric pressure ionization chamber through the through hole of the top plate, so that the liquid sample droplet does not vaporize on the orifice plate, and the orifice The small diameter hole of the plate is not clogged. In addition, the flow of the dry gas in the atmospheric pressure ionization chamber makes it possible to completely vaporize a liquid sample of several hundred μl / min in the space between the hollow needle electrode and the orifice plate. No, it can withstand continuous use for a long time. Furthermore, the solvent molecules generated by drying the microdroplets are efficiently released outside the atmospheric pressure ionization chamber along the flow of the drying gas, thereby promoting the desolvation of the cluster ions generated by drying the microdroplets. And improve the analytical sensitivity.
（２） 大気圧イオン化室内で生成されたイオンは、オ
リフィス板の小径穴を通過した後、網状の筒状電極によ
りイオン化された液体試料の粒子の拡散が抑制され、網
状の筒状電極の中央部を通るようになるため、イオンの
補集効率がよくなり、イオン源としての性能が向上する
ようになる。(2) After the ions generated in the atmospheric pressure ionization chamber pass through the small diameter hole of the orifice plate, the diffusion of the particles of the liquid sample ionized by the reticulated cylindrical electrode is suppressed, and the center of the reticulated cylindrical electrode is reduced. Since the ions pass through the portion, the ion collection efficiency is improved, and the performance as an ion source is improved.
第１図はこの発明の実施例を用いた液体クロマトグラフ
ィ質量分析計の概略構成断面図、第２図はこの発明の実
施例の液体クロマトグラフィ質量分析計用イオン源の断
面図である。第３図は従来の液体クロマトグラフィ質量
分析計用イオン源の構成図である。 図中、 11……筒状体 12……天板 12a……天板の貫通穴 13……オリフィス板 13……ａオリフィス板の小径穴 14……大気圧イオン化室 15……中空針電極 16……ガス供給管 16a……ガス供給管の噴出口 17……網状の筒状電極 18……スキマー 18a……スキマーの穴 19……加熱ヒータ 24a……絶縁体 24b……絶縁体 24c……絶縁体FIG. 1 is a schematic cross-sectional view of a liquid chromatography mass spectrometer using an embodiment of the present invention, and FIG. 2 is a cross-sectional view of an ion source for a liquid chromatography mass spectrometer according to an embodiment of the present invention. FIG. 3 is a configuration diagram of a conventional ion source for a liquid chromatography mass spectrometer. In the figure, 11: cylindrical body 12: top plate 12a: through hole of top plate 13: orifice plate 13: small diameter hole of a orifice plate 14: atmospheric pressure ionization chamber 15: hollow needle electrode 16 ... gas supply pipe 16a ... gas supply pipe spout 17 ... net-like cylindrical electrode 18 ... skimmer 18a ... skimmer hole 19 ... heater 24a ... insulator 24b ... insulator 24c ... Insulator
Claims (2)
介して取付けた貫通穴付の天板、および該筒状体の底部
の開口に絶縁体を介して取付けた小径穴付のオリフィス
板で囲むように形成された大気圧イオン化室と、上記天
板の貫通穴を、間隙を保って貫通しながら上記オリフィ
ス板の小径穴と同軸上に配設され、先端が上記大気圧イ
オン化室内で上記オリフィス板の小径穴と距離をおいて
対向する液体試料の流れる中空針電極と、上記オリフィ
ス板の小径穴と中空針電極の先端との間に向けられた噴
出口より高温の乾燥ガスを噴出する少なくとも２つ以上
のガス供給管と、上記オリフィス板の上記大気圧イオン
化室と反対側部で上記オリフィス板の小径穴と同軸上に
配設された網状の筒状電極と、該筒状電極の上記オリィ
ス板と反対側の近傍で上記オリフィス板の小径穴と同軸
上に配設された穴をもつスキマーとを備えたことを特徴
とする液体クロマトグラフィ質量分析計用イオン源。1. A cylindrical body, a top plate having a through hole attached to an opening at a top portion of the cylindrical body via an insulator, and a top plate with a through hole attached to an opening at a bottom portion of the tubular body via an insulator. An atmospheric pressure ionization chamber formed so as to be surrounded by an orifice plate with a small-diameter hole, and a through-hole of the top plate are arranged coaxially with the small-diameter hole of the orifice plate while penetrating the top plate with a gap therebetween. A hollow needle electrode through which a liquid sample flows at a distance from the small-diameter hole of the orifice plate in the atmospheric pressure ionization chamber, and a jet port directed between the small-diameter hole of the orifice plate and the tip of the hollow needle electrode. At least two or more gas supply pipes for injecting a high-temperature dry gas, and a mesh-like cylindrical electrode disposed coaxially with the small-diameter hole of the orifice plate on the side of the orifice plate opposite to the atmospheric pressure ionization chamber. And near the opposite side of the cylindrical electrode from the orifice plate. In liquid ion source for chromatography mass spectrometer, characterized in that a skimmer with a small-diameter hole and the hole disposed coaxially of the orifice plate.
を特徴とする請求項１記載の液体クロマトグラフィ質量
分析計用イオン源。2. The ion source for a liquid chromatography mass spectrometer according to claim 1, wherein a heater is provided on the outer periphery of the cylindrical body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1120647A JP2756581B2 (en) | 1989-05-15 | 1989-05-15 | Ion source for liquid chromatography mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1120647A JP2756581B2 (en) | 1989-05-15 | 1989-05-15 | Ion source for liquid chromatography mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03179252A JPH03179252A (en) | 1991-08-05 |
| JP2756581B2 true JP2756581B2 (en) | 1998-05-25 |
Family
ID=14791403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1120647A Expired - Fee Related JP2756581B2 (en) | 1989-05-15 | 1989-05-15 | Ion source for liquid chromatography mass spectrometer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2756581B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5140855A (en) * | 1990-11-13 | 1992-08-25 | Biological Monitoring, Inc. | Monitoring tank modules and array for use with biological sensors |
| EP2296167B1 (en) | 1999-09-20 | 2012-11-07 | Hitachi, Ltd. | Ion source, mass spectrometer, detector and monitoring system |
| KR100895981B1 (en) * | 2007-08-06 | 2009-05-07 | 주식회사 휴텍스 | A System and a Method for Sample Injecting Automatically for Chromatography |
| CN107121694A (en) * | 2017-05-26 | 2017-09-01 | 宜昌后皇真空科技有限公司 | A kind of method and system for monitoring pulse gas cluster ions beam on-line |
-
1989
- 1989-05-15 JP JP1120647A patent/JP2756581B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03179252A (en) | 1991-08-05 |
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