JP2613865B2 - Cosmetics - Google Patents
CosmeticsInfo
- Publication number
- JP2613865B2 JP2613865B2 JP5252245A JP25224593A JP2613865B2 JP 2613865 B2 JP2613865 B2 JP 2613865B2 JP 5252245 A JP5252245 A JP 5252245A JP 25224593 A JP25224593 A JP 25224593A JP 2613865 B2 JP2613865 B2 JP 2613865B2
- Authority
- JP
- Japan
- Prior art keywords
- present
- cosmetic
- water
- ultraviolet absorber
- basic amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、色、臭いが変化せず、
沈殿が生じないなど経時保存安定性に優れた水溶性紫外
線吸収剤含有の化粧料に関する。BACKGROUND OF THE INVENTION The present invention relates to
The present invention relates to a cosmetic containing a water-soluble ultraviolet absorber having excellent storage stability over time, such as no precipitation.
【０００２】[0002]
【従来の技術及び発明が解決しようとする課題】紫外線
により皮膚は炎症（紅斑）を起こし、黒化する。この変
化を押さえるために紫外線吸収剤を配合した製剤が汎用
されている。紫外線吸収剤としては、油溶性物質と水溶
性物質がある。油溶性紫外線吸収剤は、皮膚への塗布時
に「べたつき」があり官能特性が悪く、さらに乳化製剤
にしか使用できないといった製剤化において制限があ
る。一方、水溶性紫外線吸収剤は、「べたつき」がなく
官能特性が良く、乳化・可溶化製剤双方に配合でき製剤
の汎用性も高い。2. Description of the Related Art Ultraviolet rays cause inflammation (erythema) on the skin and cause darkening. In order to suppress this change, preparations containing an ultraviolet absorber are widely used. UV absorbers include oil-soluble substances and water-soluble substances. The oil-soluble ultraviolet absorber has a limitation in formulation such that it has "stickiness" when applied to the skin, has poor sensory characteristics, and can be used only for emulsified formulations. On the other hand, the water-soluble ultraviolet absorber has no stickiness, has good sensory characteristics, and can be blended in both emulsified and solubilized preparations, and has high versatility of the preparation.
【０００３】水溶性紫外線吸収剤は、アルカリ中和塩と
して水へ溶解する。水溶性紫外線吸収剤には、スルホン
酸等の酸が多く、その対イオンはアルカリイオンであ
る。アルカリイオンとしては、アルカリ金属塩として水
酸化ナトリウム、水酸化カリウム等、有機アミンとして
トリエタノールアミン、ジイソプロパノールアミン、ア
ミノメチルプロパール、アミノヒドロキシメチルプロパ
ンジオール等が適用される。[0003] Water-soluble ultraviolet absorbers dissolve in water as alkali neutralized salts. The water-soluble ultraviolet absorber contains many acids such as sulfonic acid, and its counter ion is an alkali ion. Examples of the alkali ion include sodium hydroxide and potassium hydroxide as alkali metal salts, and triethanolamine, diisopropanolamine, aminomethylpropal, aminohydroxymethylpropanediol, and the like as organic amines.
【０００４】しかし、水溶性紫外線吸収剤をアルカリ金
属塩で溶解した場合には、室温から低温側で沈殿が生
じ、有機アミンで溶解した場合には、高温側で黄変した
り、変臭を起こすなど保存安定性が不十分である。ま
た、皮膚の黒化やしみ、そばかすを防ぎ本来の白い肌を
保つためにＬ−アスコルビン酸誘導体を追加配合した場
合、塩析効果により沈殿が生じやすくなり、さらに保存
安定性が不十分である。However, when the water-soluble ultraviolet absorber is dissolved with an alkali metal salt, precipitation occurs from room temperature to a low temperature side, and when the water-soluble ultraviolet absorber is dissolved with an organic amine, yellowing or malodor occurs at a high temperature side. Storage stability is insufficient. Further, when an L-ascorbic acid derivative is additionally added in order to prevent darkening, spots, and freckles on the skin and keep the original white skin, precipitation tends to occur due to a salting out effect, and storage stability is insufficient. .
【０００５】本発明者らは、このような事情に鑑み鋭意
検討した結果、後記化粧料が、色、臭いが変化せず、沈
殿が生じない等経時保存安定性に優れていることを見出
し、本発明を完成するに至った。The present inventors have conducted intensive studies in view of such circumstances, and as a result, have found that the cosmetics described below have excellent storage stability over time such as no change in color and odor and no precipitation. The present invention has been completed.
【０００６】本発明の目的は、色、臭いが変化せず、沈
殿が生じない等経時保存安定性に優れた水溶性紫外線吸
収剤含有の化粧料を提供することにある。An object of the present invention is to provide a cosmetic containing a water-soluble ultraviolet absorber which is excellent in storage stability over time such as no change in color and odor and no precipitation.
【０００７】[0007]
【課題を解決するための手段】上記目的を達成する本発
明は、フェニルベンズイミダゾール−５−スルホン酸と
塩基性アミノ酸からなることを特徴とする化粧料であ
る。また、上記目的を達成する本発明は、フェニルベン
ズイミダゾール−５−スルホン酸、塩基性アミノ酸、Ｌ
−アスコルビン酸誘導体からなることを特徴とする化粧
料である。SUMMARY OF THE INVENTION The present invention, which achieves the above-mentioned object, comprises a phenylbenzimidazole-5-sulfonic acid.
A cosmetic comprising a basic amino acid . Further, the present invention for achieving the above object provides a phenylbenzene
Zimidazole-5-sulfonic acid, basic amino acid, L
-A cosmetic comprising an ascorbic acid derivative .
【０００８】以下、本発明の構成について詳述する。本
発明に用いられる水溶性紫外線吸収剤としては、対イオ
ンとして塩基性アミノ酸を持つフェニルベンズイミダゾ
ール−５−スルホン酸である。Hereinafter, the configuration of the present invention will be described in detail. The water-soluble ultraviolet absorbing agent used in the present invention, pairs Io
Phenylbenzimidazo with basic amino acids as amino acids
Sulfonic acid .
【０００９】本発明に用いられる塩基性アミノ酸として
は、ヒスチジン、リジン、アルギニン、オルニチンなど
が挙げられるがこれらに限定されるものではない。これ
らの塩基性アミノ酸は１種又は２種以上を混合して用い
られる。The basic amino acids used in the present invention include, but are not limited to, histidine, lysine, arginine, and ornithine. These basic amino acids are used alone or in combination of two or more.
【００１０】本発明に用いられるＬ−アスコルビン酸誘
導体としては、Ｌ−アスコルビル−２−リン酸ナトリウ
ム，Ｌ−アスコルビル−２−リン酸マグネシウム，Ｌ−
アスコルビル−２−リン酸カリウム，Ｌ−アスコルビル
−２−リン酸カルシウム，Ｌ−アスコルビル−２−硫酸
ナトリウム，Ｌ−アスコルビル−２−硫酸マグネシウ
ム，Ｌ−アスコルビル−２−硫酸カリウム及びＬ−アス
コルビル−２−硫酸カルシウムなどが挙げられるがこれ
らに限定されるものではない。これらのＬ−アスコルビ
ン酸誘導体は１種又は２種以上を混合して用いられる。The L-ascorbic acid derivative used in the present invention includes L-ascorbyl-2-sodium phosphate, L-ascorbyl-2-magnesium phosphate, and L-ascorbyl-2-magnesium phosphate.
Ascorbyl-2-potassium phosphate, L-ascorbyl-2-calcium phosphate, L-ascorbyl-2-sulfate, L-ascorbyl-2-magnesium sulfate, L-ascorbyl-2-potassium sulfate and L-ascorbyl-2-sulphate Examples include, but are not limited to, calcium. These L-ascorbic acid derivatives are used alone or in combination of two or more.
【００１１】本発明に用いられる水溶性紫外線吸収剤の
化粧料への配合量は化粧料全量中の総量として０．００
１〜２０重量％が好ましく、更に好ましくは０．０１〜
１０重量％である。０．００１重量％未満では有効な紫
外線吸収効果が得られにくく、２０重量％を超えてもそ
の効果分に見合った効果の向上は望めず、保存安定性が
悪くなり易く、個々の製剤を保持し難くなる。The amount of the water-soluble ultraviolet absorber used in the present invention in the cosmetic is 0.000 as a total amount in the total amount of the cosmetic.
It is preferably 1 to 20% by weight, more preferably 0.01 to 20% by weight.
10% by weight. If the amount is less than 0.001% by weight, it is difficult to obtain an effective ultraviolet absorbing effect. If the amount exceeds 20% by weight, the effect corresponding to the effect cannot be expected to be improved, and the storage stability tends to deteriorate, and individual preparations are retained. It becomes difficult to do.
【００１２】本発明に用いられる塩基性アミノ酸の化粧
料への配合量は、化粧料全量中に配合する水溶性紫外線
吸収剤を水溶液に中和溶解する量であり、その量は水溶
性紫外線吸収剤の配合量および塩基性アミノ酸の種類に
より上下する。The amount of the basic amino acid used in the present invention in the cosmetic is an amount that neutralizes and dissolves the water-soluble ultraviolet absorber incorporated in the total amount of the cosmetic in the aqueous solution. It fluctuates depending on the amount of the agent and the type of basic amino acid.
【００１３】Ｌ−アスコルビン酸誘導体の化粧料への配
合量は化粧料全量中の０．００１〜１０重量％が好まし
く、更に好ましくは０．０１〜５重量％である。０．０
０１重量％未満では美白効果が得られにくく、１０重量
％を超えると変臭、変色や沈殿を生じやすくなるため、
好ましくない。The amount of the L-ascorbic acid derivative in the cosmetic is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, based on the total amount of the cosmetic. 0.0
If it is less than 01% by weight, it is difficult to obtain a whitening effect, and if it exceeds 10% by weight, odor, discoloration and precipitation are liable to occur.
Not preferred.
【００１４】本発明の化粧料には、上記原料の他にター
ル系色素、酸化鉄などの着色顔料、パラベンなどの防腐
剤、脂肪酸セッケン、セチル硫酸ナトリウムなどの陰イ
オン性界面活性剤、ポリオキシエチレンアルキルエーテ
ル、ポリオキシエチレン脂肪酸エステル、ポリオキシエ
チレン多価アルコール脂肪酸エステル、ポリオキシエチ
レン硬化ヒマシ油、多価アルコール脂肪酸エステル、ポ
リグリセリン脂肪酸エステルなどの非イオン性界面活性
剤、テトラアルキルアンモニウム塩などの陽イオン性界
面活性剤、ベタイン型、スルホベタイン型、スルホアミ
ノ酸型、Ｎ−ステアロイル−Ｌ−グルタミン酸ナトリウ
ムなどの両イオン性界面活性剤、レシチン、リゾフォス
ファチジルコリンなどの天然系界面活性剤、酸化チタ
ン、酸化亜鉛などの顔料、ジブチルヒドロキシトルエン
などの抗酸化剤、パラメトキシケイ皮酸２−エチルヘキ
シル、４−ｔｅｒｔ−ブチル−４´−メトキシジベンゾ
イルメタンなどの油溶性紫外線吸収剤を、本発明の目的
を達成する範囲内で適宜配合することができる。The cosmetic of the present invention includes, in addition to the above-mentioned raw materials, tar pigments, coloring pigments such as iron oxide, preservatives such as parabens, anionic surfactants such as fatty acid soap and sodium cetyl sulfate, Nonionic surfactants such as ethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, polyglycerin fatty acid ester, tetraalkyl ammonium salt, etc. Cationic surfactants, amphoteric surfactants such as betaine type, sulfobetaine type, sulfoamino acid type, sodium N-stearoyl-L-glutamate, and natural surfactants such as lecithin and lysophosphatidylcholine , Titanium oxide, zinc oxide, etc. And an antioxidant such as dibutylhydroxytoluene and an oil-soluble ultraviolet absorber such as 2-ethylhexyl paramethoxycinnamate and 4-tert-butyl-4'-methoxydibenzoylmethane. Can be appropriately blended.
【００１５】本発明の化粧料の剤型としては、クリー
ム、乳液、化粧水、美容液、パックなどが挙げられる。
この化粧料は、例えば乳液等の場合、油相及び水相をそ
れぞれ加熱溶解したものを乳化分散して冷却する通常の
方法により製造することができる。Examples of the dosage form of the cosmetic of the present invention include creams, emulsions, lotions, serums, and packs.
For example, in the case of an emulsion or the like, this cosmetic can be produced by a usual method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, and cooling.
【００１６】[0016]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳述する。尚、実施例に示す％とは重量％である。実施
例に記載の保存安定性試験法は下記のとおりである。The present invention will be described below in detail based on examples and comparative examples. The percentages shown in the examples are percentages by weight. The storage stability test method described in the examples is as follows.
【００１７】保存安定性試験法試料を４５℃、２５℃及
び０℃の恒温槽に入れて経日観察を行い、下記の判定基
準に従って評価した。Storage stability test method Samples were placed in thermostats at 45 ° C., 25 ° C. and 0 ° C. and observed over time, and evaluated according to the following criteria.
【００１８】 [0018]
【００１９】ここで異常とは、変色・変臭が生じる，化
粧水で沈殿が生じる，乳化物で相分離が生じる現象を意
味する。Here, "abnormal" means a phenomenon in which discoloration / odor is generated, precipitation occurs in a lotion, and phase separation occurs in an emulsion.
【００２０】実施例１〜２、比較例１ フェニルベンズイミダゾール−５−スルホン酸と塩基性
アミノ酸を表１の組成において配合し、下記の調製方法
に基づいてスキンクリームを調製した。それぞれについ
て前記の諸試験を実施し、その結果を表２に示した。 〔組成〕Examples 1-2 , Comparative Example 1 Phenylbenzimidazole-5-sulfonic acid and a basic amino acid were blended in the composition shown in Table 1, and a skin cream was prepared according to the following preparation method. Each of the above tests was performed for each, and the results are shown in Table 2 . 〔composition〕
【００２１】[0021]
【表１】 [Table 1]
【００２２】[0022]
【表２】 [Table 2]
【００２３】〔調製方法〕 （Ａ）を７０℃、Ｂを５０℃にて均一に溶解し、（Ａ）
を攪拌しながら（Ｂ）を（Ａ）に注入して乳化分散した
後、攪拌しながら温度３０℃まで冷却して調製する。[Preparation Method] (A) was uniformly dissolved at 70 ° C. and B was uniformly dissolved at 50 ° C.
After stirring (B) into (A) while stirring to emulsify and disperse, the mixture is cooled to 30 ° C. while stirring to prepare.
【００２４】〔特性〕 本発明の実施例１、２のスキンクリームは、諸特性にお
いて顕著な効果が認められた。一方、比較例１のスキン
クリームは本発明の実施例に比べて諸特性において劣っ
ていた。[Properties] The skin creams of Examples 1 and 2 of the present invention showed remarkable effects in various properties. On the other hand, the skin cream of Comparative Example 1 was inferior in various properties as compared with the Examples of the present invention.
【００２５】実施例３ 〔スキンローション〕 表３の組成により本発明のスキンローションを下記の製
法によって調製した。 〔組成〕Example 3 [Skin lotion] The skin lotion of the present invention having the composition shown in Table 3 was prepared by the following method. 〔composition〕
【００２６】 [0026]
【００２７】〔調製方法〕 （Ａ），（Ｂ）の各成分をそれぞれ混合溶解し、（Ｂ）
を（Ａ）に加えて混合攪拌して調製した。[Preparation method] Each of the components (A) and (B) is mixed and dissolved, and (B)
Was added to (A) and mixed and stirred.
【００２８】〔特性〕 この実施例３のスキンローションは、前記諸試験すべて
において良好な結果を示した。[Properties] The skin lotion of Example 3 showed good results in all of the above tests.
【００２９】[0029]
【発明の効果】以上記載のごとく、本発明が、色、臭い
が変化せず、沈殿が生じない等保存安定性に優れた水溶
性紫外線吸収剤含有の化粧料を提供することは明らかで
ある。As described above, it is apparent that the present invention provides a cosmetic containing a water-soluble ultraviolet absorber excellent in storage stability such that the color and odor do not change and precipitation does not occur. .
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ａ６１Ｋ 7/48 Ａ６１Ｋ 7/48 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification code Agency reference number FI Technical display location A61K 7/48 A61K 7/48
Claims (2)
ン酸と塩基性アミノ酸からなることを特徴とする化粧
料。(1) Phenylbenzimidazole-5-sulfo
Cosmetics characterized by comprising an acid and a basic amino acid .
ン酸、塩基性アミノ酸、Ｌ−アスコルビン酸誘導体から
なることを特徴とする化粧料。2. Phenylbenzimidazole-5-sulfo
Acid, basic amino acid, L-ascorbic acid derivative
Cosmetics characterized by becoming .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5252245A JP2613865B2 (en) | 1993-09-14 | 1993-09-14 | Cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5252245A JP2613865B2 (en) | 1993-09-14 | 1993-09-14 | Cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0782127A JPH0782127A (en) | 1995-03-28 |
| JP2613865B2 true JP2613865B2 (en) | 1997-05-28 |
Family
ID=17234541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5252245A Expired - Fee Related JP2613865B2 (en) | 1993-09-14 | 1993-09-14 | Cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2613865B2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19713776A1 (en) * | 1997-04-03 | 1998-10-08 | Beiersdorf Ag | Light protection preparations with a content of basic amino acids and water-soluble UV filter substances |
| DE19750526A1 (en) | 1997-11-14 | 1999-05-20 | Basf Ag | Ascorbic acid derivatives containing cosmetic and pharmaceutical preparations |
| CA2394211A1 (en) * | 1999-12-15 | 2001-06-21 | Kyowa Hakko Kogyo Co., Ltd. | Stabilizers for sodium l-ascorbate-2-phosphate |
| WO2005067867A1 (en) * | 2004-01-20 | 2005-07-28 | Kose Corporation | Cosmetic |
| JP5240967B2 (en) * | 2006-02-20 | 2013-07-17 | 株式会社 資生堂 | Water-in-oil emulsified sunscreen cosmetics |
| JP5288521B2 (en) * | 2006-02-20 | 2013-09-11 | 株式会社 資生堂 | Water-in-oil emulsified sunscreen cosmetics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5814814B2 (en) * | 1977-04-19 | 1983-03-22 | 株式会社資生堂 | Stable water-in-oil emulsifier composition |
| JPH05201847A (en) * | 1992-01-28 | 1993-08-10 | Sunstar Inc | Skin-beautifying cosmetic |
| JP3162513B2 (en) * | 1992-11-11 | 2001-05-08 | ポーラ化成工業株式会社 | UV protection cosmetics |
-
1993
- 1993-09-14 JP JP5252245A patent/JP2613865B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0782127A (en) | 1995-03-28 |
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