JP2673252B2 - Hair restoration - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention contains one or more kinds of crude drug extracts and a specific surfactant, and is effective for promoting hair loss prevention, hair growth, hair growth and the like. It relates to an excellent hair nourishing agent.

[Prior Art] Conventionally, hair tonics containing various agents have been known. For example, vitamins such as vitamin B, amino acids such as methionine, vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol, skin function enhancers such as cepharanthin, etc. It is used for the prevention and treatment of alopecia.

However, conventional hair nourishing agents are said to be effective in preventing and improving dandruff, itchiness, hair loss, etc., and promote hair growth and hair growth, but none have yet achieved satisfactory effects.

[Problems to be Solved by the Invention] The present inventors have conducted diligent research to investigate a method for enhancing the effect of a naturally derived drug that is effective in preventing hair loss, hair growth, etc. It has been found that this problem can be solved by containing one or more substances and a specific surfactant, and completed the present invention.

[Means for Solving the Problems] That is, the invention according to claim 1 is assemblage, touki, carrot, ginger, tonin, capsicum, youtei, aloe, salamander, goshuyu, wolfberry, mugwort,
Mustard, rice, mankeishi, mannenrow, kossaiho, enshida, gentian, tanjin, loofah, ginkgo, pine, ginseng, ginseng, safflower, barberry, areca, perilla, eucalyptus, moss, mokutou, goshitsu, saiko, cha, okogi, Eleuthero, Shini, Wasabi, Joteishi, Dutch Sennichi, Gardenia, Usubasaicin, Garlic, Mint, Yokuinin,
Giraffe, palm, burdock, licorice, hop, chrysanthemum, rakkyo, leek, leeks, onion, azalea, sardine,
Senega, Amachazul, Ganoderma lucidum, Acacia, Astragalus, Onji, Kengoshi, Peonies, Valerian, Caterpillar, Kaigai, Nigaki, Soyo, Inchinko, Genshosho, Kakko Thistle, Clove, Oleander, Pleurotus, Oleander, Pleurotus, Oleander, Oleander , Bofu, Kouhong, Dioh, Toshishi, Kashu, Juniper, Agi, Kozui, one or more kinds of herbal extracts selected from the group consisting of Emmezo, and one or more anionic surfactants, and anionic interface Contains one or more surfactants having a nitrogen atom in the molecule other than the surfactant, the molecular ratio of the anionic surfactant and the surfactant having a nitrogen atom in the molecule is 20: 1 to 1 : 20 and the total amount is 0.001-10% by weight in the hair nourishing agent A hair tonic charge of coating, characterized and. The term "for application" as used herein means one that is not washed off during normal use, and excludes shampoos, rinses, and other items that have been rinsed.

The invention according to claim 2 is one or more kinds of the herbal medicine extract according to claim 1, one or more kinds of an amphoteric surfactant and a semipolar surfactant, and a non-containing compound having a nitrogen atom in the molecule. A hair nourishing agent containing one or more ionic surfactants.

 Hereinafter, the configuration of the present invention will be described in detail.

The crude drug extract used in the present invention includes a crude drug as a solvent, for example, hot water, lower alcohols such as methanol and ethanol, hydrous lower alcohols or polyhydric alcohols such as propylene glycol, 1-3 butylene glycol and hydrous polyhydric alcohols. Examples of the extract include extracts obtained by extraction with hydrous alcohol and the like, and extracts obtained by concentrating and drying the extracts. The compounding amount of the crude drug extract in the present invention is 0.005 to 10% by weight, preferably 0.01 to 5% by weight, as a dried product, based on the total amount of the hair restorer. If the amount is less than 0.005% by weight, the effects of the present invention are not sufficiently exhibited, which is not preferable.

Examples of the anionic surfactant according to claim 1 include anionic surfactants having one or more carboxylic acid groups, sulfonic acid groups, sulfuric acid ester groups, and phosphoric acid ester groups in the molecule. As those having a carboxylic acid group, fatty acid soap, ether carboxylic acid and salts thereof, carboxylic acid salts such as condensates of amino acids and fatty acids,
Further, those having a sulfonate include alkyl sulfonate, sulfosuccinic acid, ester sulfonate, alkylallyl and alkylnaphthalene sulfonate, N
-Acyl sulfonates, formalin condensed sulfonates and the like having a sulfate ester group include sulfated oils, ester sulfates, alkyl sulfates, ether sulfates, alkylallyl ether sulfates, amide sulfates, etc. Examples of compounds having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, and alkylallyl ether phosphates. One or more of these are arbitrarily selected.

As the surfactant having a nitrogen atom in the molecule other than the anionic surfactant according to claim 1, an amphoteric surfactant having a nitrogen atom in the molecule, a semipolar surfactant, a nonionic surfactant, Mention may be made of chaotic surfactants. As the amphoteric surfactant, N, N-dimethyl-N
Carboxybetaines such as -lauryl-N-carboxymethylammonium betaine, N, N-dimethyl-N-oleyl-N-carboxymethylammonium betaine, 2
-Lauryl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and other imidazoline derivatives, N-cocoalkyl-β-aminopropionic acid sodium salt , N-coconut alkyl-β-iminodipropionic acid-di-soda salt, and other aminocarboxylic acid salts, sulfobetaine, aminobetaine, and the like. Examples of the semipolar surfactant include dimethyllaurylamine oxide and bis- (2-hydroxyethyl) laurylamine oxide. Examples of the nonionic surfactant include fatty acid alkanolamides, polyoxyethylene fatty acid amides, esters of alkanolamines, and polyoxyethylene alkylamines. As a chaotic surfactant, a fatty acid amine salt,
Examples thereof include alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridinium salts, imidazolium salts and the like.
One or more of these are arbitrarily selected.

As the amphoteric surfactant according to claim 2, carboxybetaines such as N, N-dimethyl-N-lauryl-N-carboxymethylammonium betaine and N, N-dimethyl-N-oleyl-N-carboxymethylammonium betaine, 2-lauryl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine and other imidazoline derivatives, N-cocoalkyl-β-aminopropionate sodium Examples thereof include salts, aminocarboxylic acid salts such as N-coconut alkyl-β-iminodipropionic acid-di-soda salt, sulfobetaines, aminobetaines and the like.

Examples of the semipolar surfactant according to claim 2 include dimethyllaurylamine oxide and bis- (2-hydroxyethyl) laurylamine oxide.

Examples of the nonionic surfactant according to claim 2 include fatty acid alkanolamides, polyoxyethylene fatty acid amides, alkanolamine esters, and polyoxyethylene alkylamines.

The total amount of the anionic surfactant according to claim 1 and a surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 0.001 to 10% by weight in the total amount of the hair restorer, and more preferably It is 0.01 to 5% by weight. Also,
The ratio of the anionic surfactant and the surfactant having a nitrogen atom in the molecule other than the anionic surfactant is preferably 20: 1 to 1:20 in a molecular ratio, more preferably 10: 1 to 1 :
It is 10.

The total amount of one or more of the amphoteric surfactant and the semipolar surfactant according to claim 2 and one or more of the nonionic surfactant having a nitrogen atom in the molecule is a hair nourishing agent. The total amount is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight. Further, the ratio of one or more amphoteric surfactants and semipolar surfactants and one or more nonionic surfactants having a nitrogen atom in the molecule is 20: 1 in terms of molecular ratio. ~ 1: 20 is preferred,
More preferably, it is 10: 1 to 1:10.

In addition to the above essential ingredients, the hair nourishment according to the present invention includes general-purpose ingredients usually used in hair nourishments, such as vitamin B ₆ , vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid. And derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cepharanthin, oxendron, diazoxide, minoxidil, hair growth aids such as ethinyl estradiol, hinokitiol, hexachlorophene, phenol, Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol, cooling agents such as menthol,
Drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, oils such as higher alcohols, glycerin , Polyhydric alcohols such as propylene glycol, fragrances, antioxidants, ultraviolet absorbers, dyes, alcohols such as ethanol, benzyl alcohol and isopropyl alcohol, water, moisturizers, thickeners and the like impair the effects of the present invention. It can be appropriately blended within the range not present.

The hair restorer of the present invention may be any liquid form, emulsion, ointment, cream, gel, aerosol or any other dosage form applicable to the outer skin, and is used in the form of a tonic, conditioner, scalp treatment, shampoo, rinse, etc. .

[Examples] Next, the present invention will be described in detail with reference to examples.
The present invention is not limited to these. The compounding amount is% by weight.

Using the measurement method of the hair-growth effect (hair growth effects measured in mice) Male C ₃ H mice (60 days old), the method of Ogawa et al. [(Normal and Abnormal Epidermal Differentiatio
n) Edited by M. Seiji and IA Bernstein]. That is, about 2 × the back hair of a mouse
After shaving to a size of 4 cm, sample application was performed once a day from the next day, and the change in the area ratio of the part where hair regeneration started was determined and the speed of hair regeneration was compared. The sample is a dry extract of each crude drug extract solution dissolved in 75% ethanol with stirring,
A surfactant was added to this and dissolved to obtain a sample. The test used 75% ethanol as a control. For each sample, 10 mice were used, and the average value of the rate of change was determined.
The results of the area of hair regeneration after 20 days are shown in Table 1 in percentage.

Comparative Example 1 (1) 75% ethanol 100 Comparative Example 2 (1) 50% ethanol extract of dried sea bream (dry matter) 0.2 (2) 75% ethanol Residue Comparative Example 3 (1) 70% ethanol extract of Touki (dried) Material) 0.2 (2) 75% ethanol residue Comparative Example 4 (1) Kujin 50% ethanol extract (dry matter) 0.2 (2) 75% ethanol residue Comparative Example 5 (1) Chixetuni ginseng 50% ethanol extract ( Dry matter) 0.2 (2) 75% ethanol Residue Example 1 (1) Dodecylbenzene sulfonate 0.05 (2) Lauryl dimethylamine oxide 0.05 (3) Gardenia 70% ethanol extract (dry matter) 0.1 (4) 75% ethanol Residue Example 2 (1) Sodium lauryl sulfate 0.04 (2) Dimethyllaurylamine oxide 0.06 (3) Ethanol extract of hops (dry product) 0.1 (4) 75% ethanol Residue Example 3 (1) Dimethylstearylamine oxide 0.075 (2) Sodium lauryl sulfate 0.025 (3) Licorice hot water extract (dry matter) 0.1 (4) 75% ethanol Residual Example 4 (1) Dimethylstearylamine oxide 0.15 (2) Monosodium lauryl phosphate 0.05 (3) 50% ethanol extract (dry matter) of cashew 0.05 (4) 75% ethanol Residue Example 5 (1) Dimethylstearylamine oxide 0.03 (2) Sodium laurylmethyltaurine 0.02 (3) Mushroom extract (dry matter) 0.1 (4) Hot water extract of kohhong (dry matter) 0.05 (5) 75% ethanol Residue Example 6 (1) Betaine laurylaminoacetate 0.03 (2) Lauroyldiethanolami Do 0.02 (3) 70% ethanol extract of dried cutlet (dry matter) 0.05 (4) Bacillus methanol extract (dry matter) 0.05 (5) Calyx propanol extract (dry matter) 0.05 (4) 75% ethanol Residue Example 7 (1) Dimethyllaurylamine oxide 0.04 (2) Monosodium laurylphosphate 0.01 (3) 70% ethanol extract (dry matter) of safflower 0.05 (4) methanol extract of kossaiho (dry matter) 0.05 (5) propanol extract of eleuthero (dry matter) 0.05 (6) 75% ethanol residual Example 8 (1) Dimethyllaurylamine oxide 0.03 (2) Lauryl metal taurine sodium 0.02 (3) 70% ethanol extract of racchio (dry matter) 0.05 (4) Methanol extract of onion (dry matter) 0.05 (5) Propanol extract (dry matter) 0.05 (6) 75% ethanol Residue Example 9 (1) Laurilua Betaine noacetate 0.03 (2) Lauroyldiethanolamide 0.02 (3) 70% ethanol extract of dokkatsu (dry matter) 0.05 (4) Methanol extract of rhubarb (dry matter) 0.05 (5) Propanol extract of Mokutou (dry matter) ) 0.05 (6) 75% Ethanol Residue Example 10 (1) Dimethyloleylamine oxide 0.03 (2) Lauroyldiethanolamide 0.02 (3) 70% ethanol extract of Joteishi (dry matter) 0.05 (4) Methanol extract of Asatsuki ( Dry matter) 0.05 (5) Ganoderma lucidum propanol extract (dry matter) 0.05 (6) 75% ethanol Residue Example 11 (1) Dimethyllaurylamine oxide 0.05 (2) Sodium laurylacetate 0.01 (3) 70% ethanol of bittern Extract (dry product) 0.04 (4) Methanol extract of Diou (dry product) 0.05 (5) Sodium Caustic propanol extract (dry matter) 0.05 (6) 75% ethanol Residue Example 12 (1) Dimethyloleylamine oxide 0.06 (2) Monosodium lauryl glutamate 0.01 (3) Ginger 70% ethanol extract (dry matter) 0.04 (4) Tonin methanol extract (dry matter) 0.04 (5) Aloe propanol extract (dry matter) 0.05 (6) 75% ethanol Residue Example 13 (1) Laurylaminoacetate betaine 0.03 (2) Lauroyldiethanolamide 0.02 (3) 70% ethanol extract of mint (dry matter) 0.05 (4) Methanol extract of burdock (dry matter) 0.05 (5) Propanol extract of garlic (dry matter) 0.05 (6) 75% ethanol Residual implementation Example 14 (1) Dimethyloleylamine oxide 0.03 (2) Lauroyldiethanolamide 0.02 (3) Mustard 70% Ethanol extract (dry matter) 0.05 (4) Methanol extract of Enishida (dry matter) 0.05 (5) Propanol extract of Kagosou (dry matter) 0.05 (6) 75% ethanol Residue Example 15 (1) Dimethyl Lauryl amine oxide 0.05 (2) Sodium lauryl sulfate 0.01 (3) 70% ethanol extract of Psycho (dry product) 0.04 (4) Methanol extract of wasabi (dry product) 0.05 (5) Propanol extract of Shini (dry product) ) 0.05 (6) 75% ethanol Residue Example 16 (1) Dimethyloleylamine oxide 0.06 (2) Monosodium lauryl glutamate 0.01 (3) 70% ethanol extract (dry matter) of gentian 0.04 (4) Methanol extract of kyoto (Dry product) 0.04 (5) Propanol extract of Gosshitsu (Dry product) 0.05 (6) 75% ethanol Residue Example 17 (1 Dimethyllaurylamine oxide 0.05 (2) Sodium lauryl sulfate 0.01 (3) 70% ethanol extract of broom (dry matter) 0.04 (4) Methanol extract of ondi (dry matter) 0.05 (5) Propanol extract of senega (dry matter) Material) 0.05 (6) 75% Ethanol Residue Example 18 (1) Dimethyloleylamine oxide 0.06 (2) Monosodium lauryl glutamate 0.01 (3) 70% ethanol extract of Kengoshi (dry matter) 0.04 (4) Extraction of clove with methanol Dry matter 0.04 (5) Senso propanol extract (dry matter) 0.05 (6) 75% ethanol Residue Example 19 (1) Laurylaminoacetic acid betaine 0.03 (2) Lauroyldiethanolamide 0.02 (3) Ukogi 70 % Ethanol extract (dry matter) 0.05 (4) Methanol extract of syrup (dry matter) 0.05 (5) ) Goshuyu propanol extract (dry matter) 0.05 (6) 75% ethanol Residue Example 20 (1) Dimethyloleylamine oxide 0.03 (2) Lauroyldiethanolamide 0.02 (3) 70% ethanol extract of chive (dry matter) 0.05 (4) Methanolic extract of Heron (dry matter) 0.05 (5) Propanol extract of Bowfu (dry matter) 0.05 (6) 75% ethanol Residue Example 21 (1) Dimethyllaurylamine oxide 0.05 (2) Sodium lauryl sulfate 0.01 (3) 70% ethanol extract of Kouzui (dry matter) 0.04 (4) Methanol extract of Acacia catechu (dry matter) 0.05 (5) Propanol extract of Dermatophyta (dry matter) 0.05 (6) 75% ethanol Residual implementation Example 22 (1) Dimethyloleylamine oxide 0.06 (2) Monosodium lauryl glutamate 0.01 (3 70% ethanol extract of Shazenshi (dry matter) 0.04 (4) methanol extract of radix angelicae dahuricae (dry matter) 0.04 (5) tea propanol extract (dry matter) 0.05 (6) 75% ethanol balance As is clear from Table 1, the effect on hair regeneration was observed in each example.

Example 23 Hair Tonic By adjusting the tonic having the composition shown below, the effect on symptoms such as dandruff, hair growth and hair loss was examined in actual use.

20 men (aged) with symptoms such as dandruff, hair growth, and hair loss
24 to 60 years old) was applied once or twice a day at a rate of 1 to 5 ml for 4 months, and the results shown in Table 2 were obtained. It had excellent symptoms such as dandruff, hair growth and hair loss.

(1) Jasho 70% ethanol extract (dry matter) 0.05 (2) Fennel 90% ethanol extract (dry matter) 1.0 (3) Chrysanthemum methanol extract (dry matter) 0.5 (4) Dimethyllaurylamine oxide 0.3 ( 5) Sodium lauryl sulfate 0.05 (6) Propylene glycol 5.0 (7) Sodium hyaluronate 0.01 (8) 75% ethanol Residual In Table 2 above, the effect was determined based on the following criteria.

1. Antidandruff effect test "Ineffective" means that no improvement is seen regardless of treatment.

 "Effective" means that the occurrence of dandruff has been reduced.

 "Excellent effect" means that the occurrence of dandruff has stopped.

2. Hair growth effect test "Ineffective" means that no improvement is seen regardless of treatment.

“Effective” means that hair growth is observed in more than 2/3 of the hair loss area.

 "Excellent effect" means that the hair has grown on the epilation area.

2. Hair loss effect test "Ineffective" means that no improvement is seen regardless of treatment.

 "Effective" means that the progress of hair loss was reduced.

 "Effectiveness" means that hair loss has stopped.

Example 24 Heartic (1) Eucalyptus methanol extract (dry matter) 0.05 (2) Yokuinin 80% ethanol extract (dry matter) 0.05 (3) Leek 1,3-butylene glycol extract (dry matter) 0.05 (4) 90% ethanol extract of Usabasaicin (dry product) 0.05 (5) Hot water extract of Gensho (dry product) 0.05 (6) 70% ethanol extract of Inchinko (dry product)
0.05 (7) Dimethyllaurylamine oxide 0.01 (8) Polyoxyethylene (8 mol) oleyl alcohol ether 0.05 (9) 1,3-butylene glycol 0.05 (10) 60% ethanol Residual Example 24 is excellent in hair nourishing effect. Was there.

[Effects of the Invention] The hair nourishing agent of the present invention contains various kinds of properties (for example, hair growth, hair growth, hair loss prevention) which are remarkably superior to those of the conventional hair nourishing agent by containing the crude drug extract and the specific surfactant. Effect etc.)
Is shown.

Front page continued (72) Inventor Kiyoshi Miyazawa, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Research Institute Co., Ltd.

Claims (2)

(57) [Claims] 1. Assemblage, touki, carrot, ginger,
Tonin, Capsicum, Youtei, Aloe, Peppermint, Goshuyu, Cucumber, Artemisia, Mustard, Rice, Mankeishi, Mannenrou, Kossaijo, Enishida, Gentian,
Tanjin, loofah, kyoto, pine, kudzu, chixenin ginseng, safflower, barberry, areca, perilla, eucalyptus, Kagosou, mokutou, goshitsu, psycho, cha, ukulegi, elephant's fox, shinui, horseradish, jadeish, netherlands, gardenia, gardenia, Usbasaicin, garlic, peppermint, yokinin, giraffe, palm, burdock, licorice, hops, chrysanthemum, lacchio, leek, leek, onion,
Asatsuki, Shishido, Senega, Achacha, Ganoderma lucidum, Acacia pygmaum, Fennel, Onji, Kengoshi, Peonies, Cleoptera, Catalpa, Kaigai, nigaki,
Soybean, Chinese mackerel, Gentian ginger, Cichlid thistle, Clove, Rhubarb, Senso, Chazenzi, Gobaishi, Dokatsu, Kyoukatsu, Jasho, Bouki, Boufu, Kouhon, Dioh, Toshishi, Kashu, Juniperus, Aghi, Kozui, Emmezo It contains one or more kinds of crude drug extracts, one or more kinds of anionic surfactants, and one or more kinds of surfactants having a nitrogen atom in the molecule other than anionic surfactants. The molecular ratio of the anionic surfactant to the surfactant having a nitrogen atom in the molecule is 20: 1 to 1:20 and the total amount thereof is 0.001 to 10% by weight in the hair nourishing agent. Hair nourishing agent for application. 2. Assembly, Toki, carrot, ginger,
Tonin, Capsicum, Youtei, Aloe, Peppermint, Goshuyu, Cucumber, Artemisia, Mustard, Rice, Mankeishi, Mannenrou, Kossaijo, Enishida, Gentian,
Tanjin, loofah, kyoto, pine, kudzu, chixenin ginseng, safflower, barberry, areca, perilla, eucalyptus, Kagosou, mokutou, goshitsu, psycho, cha, ukulegi, elephant's fox, shinui, horseradish, jadeish, netherlands, gardenia, gardenia, Usbasaicin, garlic, peppermint, yokinin, giraffe, palm, burdock, licorice, hops, chrysanthemum, lacchio, leek, leek, onion,
Asatsuki, Shishido, Senega, Achacha, Ganoderma lucidum, Acacia pygmaum, Fennel, Onji, Kengoshi, Peonies, Cleoptera, Catalpa, Kaigai, nigaki,
Soybean, Chinese mackerel, Gentian ginger, Cichlid thistle, Clove, Rhubarb, Senso, Chazenzi, Gobaishi, Dokatsu, Kyoukatsu, Jasho, Bouki, Boufu, Kouhon, Dioh, Toshishi, Kashu, Juniperus, Aghi, Kozui, Emmezo One or more kinds of crude drug extracts, one or more kinds selected from the group consisting of an amphoteric surfactant, dimethyllaurylamine oxide and bis- (2-hydroxyethyl) laurylamine oxide, and a nitrogen atom in the molecule A hair nourishing agent containing one or more nonionic surfactants having