JP2024013088A - Liquid composition for oral cavity - Google Patents

Abstract

To provide technique enabling suppression of intraoral discoloration occurring when liquid composition for oral cavity, including a water-soluble copper salt is applied.SOLUTION: Liquid composition for oral cavity including (a) a water-soluble copper salt and (b) a coloring inhibitor is provided, the liquid composition for oral cavity has a color difference ΔE* measured by the following method of 10 or more. The method comprises: 1. adding an aqueous tannic acid solution to a liquid composition for oral cavity to prepare a measurement solution with a final tannic acid concentration of 0.2 mass%; 2. leaving the measurement solution at 37°C for 1 week; 3. after standing still, centrifuging the measurement solution, collecting the precipitate and measuring the color of the precipitate using a spectrocolorimeter to obtain colorimetric values (L2*, a2*, b2*); 4. obtaining colorimetric values (L1*, a1*, b1*) using a 0.1 mass% copper gluconate aqueous solution as an object using the above steps 1. to 3.; and 5 calculating the color difference ΔE* by the following formula (I): ΔE*=((L2*-L1*)2+(a2*-a1*)2+(b2*-b1*)2)1/2 (I).SELECTED DRAWING: None

Description

FIELD OF THE INVENTION The present invention relates to liquid oral compositions.

Techniques for blending copper compounds into oral preparations include those described in Patent Document 1 (Japanese Patent Application Laid-Open No. 11-269073) and Patent Document 2 (Japanese Patent Application Laid-Open No. 2021-91654).

Patent Document 1 describes a preparation containing a salt of copper chlorophyllin and an acid (claim 1), and a method of adding an acid to prevent tongue coloring due to the salt of copper chlorophyllin (claim 7). has been done. The same document also describes that the degree of tongue coloring was observed for granules containing copper chlorophyllin potassium and citric acid (Example 1) and chewable tablets containing copper chlorophyllin potassium and citric acid. (Table 1, etc.)

Patent Document 2 describes a technology related to a dentifrice composition that contains a water-soluble polyvalent metal salt, is easy to put on a toothbrush, has excellent moldability, and is easily discharged from a storage container even after storage (paragraph 0001). A dentifrice composition containing one or more water-soluble polyvalent metal salts selected from polyvalent aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound is described (Claim 1). ).

Japanese Patent Application Publication No. 11-269073 JP2021-91654A

On the other hand, the present inventors have found that when a water-soluble copper salt such as copper gluconate is blended into a liquid oral composition, discoloration may occur in the oral cavity, for example, on the tongue, oral mucosa, or teeth. .

Therefore, the present invention provides a technique for suppressing coloring in the oral cavity when applying a liquid oral composition containing a water-soluble copper salt.

The present inventors have intensively investigated the cause of coloration when using a liquid oral composition containing a water-soluble copper salt. As a result, one of the causes was found to be a reaction between the water-soluble copper salt in the liquid oral composition and components present in the oral cavity. For example, it has been revealed that the coexistence of water-soluble copper salts and polyphenols (such as tannic acid) contained in tea can result in brown precipitates.

Therefore, the present inventors conducted further studies to suppress the coloring caused by the water-soluble copper salt in the liquid oral composition and the components present in the oral cavity, and found that the color characteristics of the liquid oral composition could be controlled. We have newly discovered that it is effective to do this, and have completed the present invention.

According to the present invention, the following liquid oral cavity composition and method for suppressing tooth discoloration are provided.
[1] A liquid oral composition comprising (a) a water-soluble copper salt, and (b) a coloring inhibitor,
A liquid oral composition having a color difference ΔE ^* of 10 or more as measured by the following method.
(Method)
10 mL of a 0.8% by mass aqueous solution of tannic acid is added to 1.30 mL of the liquid oral composition to prepare a measurement solution with a final tannic acid concentration of 0.2% by mass.
2. The measurement solution is allowed to stand at 37°C for one week.
3. After standing still, centrifugation is performed at room temperature and 3000 rpm for 10 minutes, the supernatant is removed, and the precipitate is collected. The color of the precipitate is measured with a spectrocolorimeter to obtain colorimetric values (L2 ^* , a2 ^* , b2 ^* ) defined by the CIE1976L ^* a ^* b ^* color system.
4. Using 0.1% by mass copper gluconate aqueous solution as a control, the above 1. ~3. Obtain colorimetric values (L1 ^* , a1 ^* , b1 ^* ) defined by the CIE1976L ^* a ^* b ^* color system using the following procedure.
5. The color difference ΔE ^* is calculated using the following formula (I).
ΔE ^* = ((L2 ^* - L1 ^* ) ² + (a2 ^* - a1 ^* ) ² + (b2 ^* - b1 ^* ) ² ) ^1/2 (I)
[2] The liquid oral composition according to [1], which has a pH of 3.5 or more and 8 or less at 25°C.
[3] The liquid oral composition according to [1] or [2], wherein the component (b) is a water-soluble aluminum salt.
[4] The liquid oral composition according to [3], wherein the water-soluble aluminum salt is an aluminum salt of an organic acid.
[5] The water-soluble aluminum salt is one or more selected from the group consisting of aluminum lactate, potassium aluminum sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and aluminum allantoin chlorohydroxy. [3 The liquid oral composition described in ].
[6] Any one of [1] to [5], wherein the component (a) is one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. Liquid oral composition according to one of the above.
[7] The content of the component (b) to the content of the component (a) in the liquid oral composition is 0.25 or more and 300 or less in mass ratio, [1] to [6] Liquid oral composition according to any one of the above.
[8] The liquid oral composition according to any one of [1] to [7], which is a tongue coloring inhibitor.
[9] The liquid oral composition according to any one of [1] to [8], which is an oral mucosa coloring inhibitor.
[10] The liquid oral composition according to any one of [1] to [9], which is a mouthwash.
[11] Contains (a) a water-soluble copper salt, and (b) a coloring inhibitor,
A method for suppressing tooth discoloration, comprising applying to the oral cavity a composition having a color difference ΔE ^* of 10 or more as measured by the following method.
(Method)
10 mL of a 0.8% by mass aqueous solution of tannic acid is added to 1.30 mL of the above composition to prepare a measurement solution with a final tannic acid concentration of 0.2% by mass.
2. The measurement solution is allowed to stand at 37°C for one week.
3. After standing still, centrifugation is performed at room temperature and 3000 rpm for 10 minutes, the supernatant is removed, and the precipitate is collected. The color of the precipitate is measured with a spectrocolorimeter to obtain colorimetric values (L2 ^* , a2 ^* , b2 ^* ) defined by the CIE1976L ^* a ^* b ^* color system.
4. Using 0.1% by mass copper gluconate aqueous solution as a control, the above 1. ~3. Obtain colorimetric values (L1 ^* , a1 ^* , b1 ^* ) defined by the CIE1976L ^* a ^* b ^* color system using the following procedure.
5. The color difference ΔE ^* is calculated using the following formula (I).
ΔE ^* = ((L2 ^* - L1 ^* ) ² + (a2 ^* - a1 ^* ) ² + (b2 ^* - b1 ^* ) ² ) ^1/2 (I)

Note that arbitrary combinations of these configurations and expressions of the present invention converted between methods, devices, etc. are also effective as aspects of the present invention.

According to the present invention, it is possible to suppress discoloration in the oral cavity when applying a liquid oral composition containing a water-soluble copper salt.

Embodiments of the present invention will be described below. In this embodiment, the composition may contain each component alone or in combination of two or more.
In this specification, "~" indicating a numerical range represents the above or below, and includes both ends of the numerical value.

(Liquid oral composition)
In this embodiment, the liquid oral composition contains the following components (a) and (b).
(a) Water-soluble copper salt (b) Coloration inhibitor The liquid oral composition has a color difference ΔE ^* of 10 or more as measured by the following method.
(Method)
10 mL of a 0.8% by mass aqueous solution of tannic acid is added to 1.30 mL of the liquid oral composition to prepare a measurement solution with a final tannic acid concentration of 0.2% by mass.
2. The measurement solution is allowed to stand at 37°C for one week.
3. After standing still, centrifugation is performed at room temperature and 3000 rpm for 10 minutes, the supernatant is removed, and the precipitate is collected. The color of the precipitate was measured with a spectrocolorimeter (specifically, SE7700, manufactured by Nippon Denshoku Kogyo Co., Ltd.), and the colorimetric values specified by the CIE1976L ^* a ^* b ^* color system (L2 ^* , a2 ^* , b2 ^* ) get.
4. Using 0.1% by mass copper gluconate aqueous solution as a control, the above 1. ~3. Obtain colorimetric values (L1 ^* , a1 ^* , b1 ^* ) defined by the CIE1976L ^* a ^* b ^* color system using the following procedure.
5. The color difference ΔE ^* is calculated using the following formula (I).
ΔE ^* = ((L2 ^* - L1 ^* ) ² + (a2 ^* - a1 ^* ) ² + (b2 ^* - b1 ^* ) ² ) ^1/2 (I)
Here, step 3 above. and 4. Specifically, the colorimetric values in are measured under a D65 light source.

The present inventor has determined that the liquid oral composition contains components (a) and (b), and also controls the color characteristics of the liquid oral composition, specifically, the color difference ΔE ^* calculated by the above formula (I). We have newly discovered that by doing so, it is possible to effectively suppress coloring caused by water-soluble copper salts and components present in the oral cavity. Specifically, the present inventors have found that ΔE ^* obtained from colorimetric values after accelerated testing of liquid oral compositions and specific reference solutions is suitable as an indicator of coloring in the oral cavity; It has been revealed that a liquid oral cavity composition having an excellent effect of suppressing intraoral coloration can be obtained by setting ΔE ^* in a specific range relative to a reference liquid.

The colorimetric value ΔE ^* of the liquid oral composition calculated by the above formula (I) is preferably 10 or more, from the viewpoint of improving the coloring suppression effect when applying the liquid oral composition to the oral cavity. is 12 or more, more preferably 15 or more, even more preferably 20 or more.
In addition, if ΔE ^* is too large, the color will be of a different type, making the cause of the coloring unclear. Therefore, the colorimetric value ΔE ^* of the liquid oral composition calculated by the above formula (I) is as follows: For example, it is 100 or less, preferably 90 or less, more preferably 80 or less, still more preferably 70 or less.

Also, step 3 above. and 4. From the colorimetric values obtained, ΔL ^* , Δa ^* , and Δb ^* of the liquid oral composition can be determined using the following formula.
ΔL ^* = (L2 ^* - L1 ^* ) ²
Δa ^* = (a2 ^* - a1 ^* ) ²
Δb ^* = (b2 ^* - b1 ^* ) ²

The ΔL ^* of the liquid oral cavity composition is preferably 10 or more, more preferably 20 or more, and even more preferably 30 or more, from the viewpoint of improving the coloration suppressing effect.
Further, from the same viewpoint, ΔL ^* of the liquid oral cavity composition is preferably 80 or less, more preferably 70 or less, still more preferably 60 or less.

The Δa ^* of the liquid oral cavity composition may be, for example, 0.05 or more, and preferably 0.1 or more, from the viewpoint of improving the coloration suppressing effect.
In addition, from the viewpoint of improving the effect of suppressing coloration, the Δa ^* of the liquid oral cavity composition is preferably 10 or less, more preferably 7 or less, and still more preferably 4 or less.

The Δb ^* of the liquid oral cavity composition is preferably -20 or more, more preferably -15 or more, and still more preferably -10 or more from the viewpoint of improving the coloration suppressing effect.
Further, from the viewpoint of improving the coloration suppressing effect, the Δb ^* of the liquid oral cavity composition is preferably 10 or less, more preferably 4 or less, and even more preferably 3 or less.

The pH of the liquid oral composition at room temperature (25° C., the same applies hereinafter) is preferably 3.5 or higher, more preferably 4.0 or higher, from the viewpoint of suppressing tooth demineralization, and For example, it is also preferably 4.5 or more, or 5 or more, or 5.5 or more.
In addition, from the viewpoint of improving the effect of suppressing coloration, the pH of the liquid oral cavity composition at room temperature is preferably 8 or less, more preferably 7.5 or less, and still more preferably 7 or less.

Next, the components contained in the liquid oral composition will be explained.

(Component (a))
Component (a) is a water-soluble copper salt, and specifically refers to a water-soluble one among inorganic acid salts of copper and organic acid salts of copper. The water-soluble copper salt may be either anhydrous or hydrated. Component (a) may be anything that is used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
In addition, the component (a) is, for example, one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. From the viewpoint of further improving the mixing effect of the water-soluble copper salt, such as the halitosis suppressing effect, the water-soluble copper salt preferably contains copper gluconate and copper sulfate, and more preferably copper gluconate.
As component (a), for example, commercially available products can be used.

The content of component (a) in the liquid oral composition is preferably 0.001 mass based on the entire liquid oral composition from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect. % or more, more preferably 0.01% by mass or more, still more preferably 0.03% by mass or more, even more preferably 0.08% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring in the oral cavity, the content of component (a) in the liquid oral composition is preferably 10% by mass or less, more preferably The content is 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, even more preferably 0.2% by mass or less.

In addition, the content of component (a) in the liquid oral composition is preferably 0.001% by mass as the amount of copper blended from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect. The content is more preferably 0.003% by mass or more, and may be, for example, 0.01% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring in the oral cavity, the content of component (a) in the liquid oral composition is preferably 0.08% by mass or less, more preferably 0.08% by mass or less, as the amount of copper blended. It is not more than .06% by mass, and may be, for example, not more than 0.03% by mass.

(Component (b))
Component (b) is a coloring inhibitor.
Specific examples of component (b) include water-soluble aluminum salts.

Component (b) is preferably a water-soluble aluminum salt from the viewpoint of more stably obtaining the effect of suppressing coloration in the oral cavity.
Specifically, the water-soluble aluminum salt refers to a water-soluble one among inorganic acid salts of aluminum and organic acid salts of aluminum. Any water-soluble aluminum salt may be used as long as it is used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.

From the viewpoint of more stably suppressing intraoral coloration, the water-soluble aluminum salt is preferably a group consisting of aluminum lactate, aluminum potassium sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and allantoin chlorohydroxy aluminum. One or more types selected from.

From the viewpoint of more stably suppressing coloring in the oral cavity, the water-soluble aluminum salt is preferably an aluminum salt of an organic acid.
The aluminum salt of an organic acid is, for example, one or more selected from the group consisting of aluminum lactate, aluminum citrate, and aluminum benzoate, and preferably aluminum lactate.

The content of the water-soluble aluminum salt in the liquid oral composition is preferably 0.01% by mass or more, more preferably The content is 0.03% by mass or more, more preferably 0.06% by mass or more, even more preferably 0.1% by mass or more, even more preferably 0.15% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring and suppressing the metallic taste, the content of the water-soluble aluminum salt in the liquid oral composition is preferably 5% by mass or less, more preferably 5% by mass or less, based on the entire liquid oral composition. is 3.5% by mass or less, more preferably 3% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less.

In addition, the content of water-soluble aluminum salt in the liquid oral composition is preferably 0.002% by mass or more, more preferably 0.002% by mass or more, based on the aluminum content, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. It is .005% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring and suppressing the metallic taste, the content of water-soluble aluminum salt in the liquid oral composition may be, for example, 1% by mass or less, preferably 0. The content is .5% by mass or less, more preferably 0.2% by mass or less.

The total content of component (b) in the liquid oral composition is preferably 0.01% by mass or more, more preferably 0.01% by mass or more based on the entire liquid oral composition, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. is 0.03% by mass or more, more preferably 0.06% by mass or more, even more preferably 0.1% by mass or more, even more preferably 0.15% by mass or more.
In addition, from the viewpoint of improving the coloration suppressing effect, the total content of component (b) in the liquid oral composition is preferably 5% by mass or less, more preferably 3.0% by mass or less, based on the entire liquid oral composition. It is 5% by mass or less, more preferably 3% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less.

In addition, the content of component (a) to the content of component (a) in the liquid oral composition (water solubility (b)/(a)) is a mass ratio, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. Therefore, it is preferably 0.25 or more, more preferably 0.5 or more.
Further, from the viewpoint of suppressing metallic taste, the above mass ratio (water-soluble aluminum salt/water-soluble copper salt) is preferably 300 or less, more preferably 100 or less, still more preferably 50 or less, and even more preferably 20 or less. , more preferably 5 or less.

In this embodiment, preferably component (a) is copper gluconate and component (b) is aluminum lactate.
At this time, the content of copper gluconate is preferably 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition, and the content of aluminum lactate is preferably 0.01% by mass or more and 0.2% by mass or less with respect to the entire liquid oral composition. It is preferably 0.01% by mass or more and 3% by mass or less based on the whole.

(water)
Liquid oral compositions specifically include water.
The content of water in the liquid oral composition can be, for example, the remainder after removing components other than water in the liquid oral composition.

Further, the content of water in the liquid oral composition is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, based on the entire liquid oral composition. It is preferably 99.99% by mass or less, more preferably 99.90% by mass or less.

(Other ingredients)
The liquid oral composition may contain components other than the above-mentioned components as long as the effects of the present invention are not impaired.
Such components include, for example, medicinal ingredients, abrasives, binders, thickeners, surfactants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, and detergents. agents, adsorbents, etc., and can be appropriately selected depending on the dosage form. Specific examples of additive components are shown below, but the components that can be blended in the present invention are not limited to these.

Examples of medicinal ingredients include one or two selected from the group consisting of bactericidal agents, anti-inflammatory agents, blood circulation promoters, tartar deposition inhibitors, stain removers, hypersensitivity inhibitors, vitamins, and plaque-degrading enzymes. The above can be mentioned. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals and the like.

Among medicinal ingredients, the bactericidal agent is selected from the group consisting of, for example, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroylsarcosine, and triclosan. One or more types may be mentioned.

Examples of anti-inflammatory agents include β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, tranexamic acid, and ε-aminocapron. Examples include one or more selected from the group consisting of acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterin, dihydrocholesterol, and lysozyme hydrochloride.

Examples of blood circulation promoters include sodium chloride.

Examples of tartar deposition inhibitors include zeolite, disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, and phosphoric acid. Examples include one or more selected from the group consisting of sodium hydrogen hydrate, disodium hydrogen phosphate (crystal), trisodium phosphate, and sodium polyphosphate.

Examples of the stain remover include Macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000). etc.), sodium polyphosphate, and polyvinylpyrrolidone.

Examples of the hypersensitivity suppressant include at least one selected from the group consisting of potassium nitrate and aluminum salts other than water-soluble aluminum salts.

Examples of vitamin preparations include ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, pyridoxine hydrochloride, DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotine. One or more types selected from the group consisting of acid esters can be mentioned.

Examples of plaque-degrading enzymes include dextranase.

Examples of abrasives include silica-based abrasives such as silicic anhydride, silica (crystalline silica or amorphous silica), silica gel, and aluminosilicate; zeolite, calcium hydrogen phosphate anhydrate, and calcium hydrogen phosphate dihydrate. selected from the group consisting of calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasives. One or more types may be mentioned.

Examples of binders include pullulan, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinyl Examples include one or more selected from the group consisting of organic binders such as pyrrolidone and carboxyvinyl polymers, thickening silicic anhydride, and bentonite.

The thickening agent may be one that is commercially available as a raw material for pharmaceuticals, foods, and cosmetics, such as polyhydric alcohols, more specifically sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3- Examples include one or more selected from the group consisting of butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylit, maltit, lactit, trehalose, sodium hyaluronate, and hydrolyzed collagen. .

Specific examples of the surfactant include anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, and preferably anionic surfactants, nonionic surfactants, and amphoteric surfactants. One or more selected from the group consisting of:

Anionic surfactants include, for example, N-acylamino acid salts, α-olefin sulfonates, N-acyl sulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters. One or more selected types may be mentioned.
Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and One or more types selected from the group consisting of glycerin fatty acid esters can be mentioned.
Examples of amphoteric surfactants include one or more selected from the group consisting of alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and coconut oil fatty acid amide alkyl betaine.

Examples of flavoring agents include monosodium L-glutamate, saccharin, sodium saccharin, disodium glycyrrhizinate, trisodium glycyrrhizinate, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, xylitol, inositol, D-sorbitol. , D-mannitol, arabitol, raffinose, lactulose, lactitol, erythritol, reduced palatinose, palatinose, palatinite, acesulfame K, maltose, maltosyltrehalose or maltitol, neohesperidin dihydrochalcone, perillartin, p-methoxycinnamic aldehyde and thaumatin One or more types selected from the group consisting of:

Examples of preservatives include paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol and ethanol; sorbic acid and benzoic acid. , dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, and alkyldiaminoethylglycine hydrochloride.

Examples of the flavor include one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavor, and peppermint oil.

Examples of colorants include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red malt pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, coumarind pigment; A type selected from the group consisting of legal pigments such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1; riboflavin, and titanium dioxide. Or two or more types can be mentioned.

Examples of pH adjusting agents include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, sodium acetate hydroxide, potassium hydroxide, A group consisting of acids, alkalis, and buffers such as sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate. One or more types selected from the following may be mentioned.

Examples of the solvent include, in addition to the above-mentioned water, lower alcohols such as ethanol and propanol.

A solubilizer may be added to promote dissolution of the above additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol.

Examples of the base include sodium hydrogen carbonate.

Examples of cleaning agents include sodium polyphosphate.

Examples of adsorbents include β-cyclodextrin.

Furthermore, in addition to the above-mentioned components, components suitable for use in oral compositions such as liquid oral compositions can also be appropriately blended within a range that does not impair the content of the present invention.

(liquid preparation)
Moreover, the liquid oral composition is specifically a liquid preparation. Liquid formulations are specifically oral formulations.
Specific embodiments of the liquid oral composition include one selected from the group consisting of mouthwashes, liquid toothpastes, and mouth fresheners. The liquid oral composition is preferably a mouthwash.

(Production method)
In this embodiment, the liquid oral composition includes, for example, a step of blending components (a), (b), water, and other components as appropriate.

Here, the above formula difference ΔE ^* can be controlled, for example, by appropriately adjusting the type and blending ratio of each component constituting the liquid oral composition.
More specifically, in this embodiment, it is important to design a formulation by appropriately selecting and combining the types and amounts of components (a) and (b).

The liquid oral composition obtained in this embodiment contains components (a) and (b) and has the above-mentioned ΔE ^* within a specific range. Alternatively, discoloration of teeth can be effectively suppressed.

The liquid oral composition obtained in this embodiment is suitably used as, for example, a tongue coloring inhibitor, an oral mucosa coloring inhibitor, or a tooth coloring inhibitor.

In the present embodiment, the method for suppressing tongue discoloration, the method for suppressing oral mucosal discoloration, and the method for suppressing tooth discoloration all involve applying a composition containing components (a) and (b) and having a ΔE ^* of 10 or more to the oral cavity. Including applying.

Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various configurations other than those described above may also be adopted.

The present embodiment will be specifically described below with reference to Examples and Comparative Examples, but the present embodiment is not limited to these Examples.

(Test example)
(Examples 1 to 4, Comparative Examples 1 to 7)
Mouthwashes for each example were prepared by mixing the components listed in Table 1, and evaluated by the method described below. Details of the components listed in each table are shown below.
Copper gluconate: Fuso Chemical Industry Co., Ltd. Aluminum lactate: Fujifilm Wako Pure Chemical Industries, Ltd. Tannic acid: Nacalai Tesque Co., Ltd.

(color measurement)
To 30 mL of the mouthwash of each example, 10 mL of a 0.8% by mass aqueous solution of tannic acid was added, so that the final concentration of tannic acid was 0.2% by mass, and the final concentration of components (a) and (b) was Measurement solutions having the concentrations shown in Table 1 were prepared.
The obtained measurement solution was allowed to stand at 37°C for one week.
After standing still, centrifugation is performed at room temperature and 3000 rpm for 10 minutes, the supernatant is removed, and the precipitate is collected. The color of the precipitate was measured using a spectrophotometer (SE7700, manufactured by Nippon Denshoku Kogyo Co., Ltd.) under a D65 light source, and the colorimetric values specified by the CIE1976L ^* a ^* b ^* color system (L2 ^* , a2 ^* , b2 ^* ) obtained.
On the other hand, 0.1% by mass copper gluconate aqueous solution was used as Control Example 1, and the above 1. ~3. Colorimetric values (L1 ^* , a1 ^* , b1 ^* ) defined by the CIE1976L ^* a ^* b ^* color system were obtained using the following procedure.
The color difference ΔE ^* was calculated using the following formula (I).
ΔE ^* = ((L2 ^* - L1 ^* ) ² + (a2 ^* - a1 ^* ) ² + (b2 ^* - b1 ^* ) ² ) ^1/2 (I)
The measurement results are also shown in Table 1.

(pH measurement)
The pH of the mouthwash in each example at 25° C. was measured using a pH meter (LAQUAtwin, manufactured by As One Corporation).
The measurement results are also shown in Table 1.

(Evaluation method)
Samples for evaluation were prepared by adding 10 mL of a 0.8% by mass aqueous solution of tannic acid to 30 mL of the mouthwash of each example. The color of the precipitate in the obtained sample was visually confirmed, and compared with Control Example 1, it was evaluated based on the following criteria. The results are also shown in Table 1.
-: Deterioration ±: No change +: Improvement

From Table 1, in each Example, since the ΔE ^* of the mouthwash was within a specific range, coloring when coexisting with tannic acid could be suitably suppressed.

Claims (11)

A liquid oral composition comprising (a) a water-soluble copper salt, and (b) a coloring inhibitor,
A liquid oral composition having a color difference ΔE ^* of 10 or more as measured by the following method.
(Method)
10 mL of a 0.8% by mass aqueous solution of tannic acid is added to 1.30 mL of the liquid oral composition to prepare a measurement solution with a final tannic acid concentration of 0.2% by mass.
2. The measurement solution is allowed to stand at 37°C for one week.
3. After standing still, centrifugation is performed at room temperature and 3000 rpm for 10 minutes, the supernatant is removed, and the precipitate is collected. The color of the precipitate is measured with a spectrocolorimeter to obtain colorimetric values (L2 ^* , a2 ^* , b2 ^* ) defined by the CIE1976L ^* a ^* b ^* color system.
4. Using 0.1% by mass copper gluconate aqueous solution as a control, the above 1. ~3. Obtain colorimetric values (L1 ^* , a1 ^* , b1 ^* ) defined by the CIE1976L ^* a ^* b ^* color system using the following procedure.
5. The color difference ΔE ^* is calculated using the following formula (I).
ΔE ^* = ((L2 ^* - L1 ^* ) ² + (a2 ^* - a1 ^* ) ² + (b2 ^* - b1 ^* ) ² ) ^1/2 (I) The liquid oral composition according to claim 1, having a pH of 3.5 or more and 8 or less at 25°C. The liquid oral composition according to claim 1 or 2, wherein the component (b) is a water-soluble aluminum salt. 4. The liquid oral composition according to claim 3, wherein the water-soluble aluminum salt is an aluminum salt of an organic acid. 4. The water-soluble aluminum salt is one or more selected from the group consisting of aluminum lactate, potassium aluminum sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and aluminum allantoin chlorohydroxy. liquid oral composition. The liquid oral composition according to claim 1 or 2, wherein the component (a) is one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. thing. The liquid oral cavity according to claim 1 or 2, wherein the content of the component (b) to the content of the component (a) in the liquid oral composition is 0.25 or more and 300 or less in mass ratio. Composition for use. The liquid oral composition according to claim 1 or 2, which is a tongue coloring inhibitor. The liquid oral composition according to claim 1 or 2, which is an oral mucosa coloring inhibitor. The liquid oral composition according to claim 1 or 2, which is a mouthwash. (a) a water-soluble copper salt; and (b) a coloring inhibitor;
A method for suppressing tooth discoloration, comprising applying to the oral cavity a composition having a color difference ΔE ^* of 10 or more as measured by the following method.
(Method)
10 mL of a 0.8% by mass aqueous solution of tannic acid is added to 1.30 mL of the above composition to prepare a measurement solution with a final tannic acid concentration of 0.2% by mass.
2. The measurement solution is allowed to stand at 37°C for one week.
3. After standing still, centrifugation is performed at room temperature and 3000 rpm for 10 minutes, the supernatant is removed, and the precipitate is collected. The color of the precipitate is measured with a spectrocolorimeter to obtain colorimetric values (L2 ^* , a2 ^* , b2 ^* ) defined by the CIE1976L ^* a ^* b ^* color system.
4. Using 0.1% by mass copper gluconate aqueous solution as a control, the above 1. ~3. Obtain colorimetric values (L1 ^* , a1 ^* , b1 ^* ) defined by the CIE1976L ^* a ^* b ^* color system using the following procedure.
5. The color difference ΔE ^* is calculated using the following formula (I).
ΔE ^* = ((L2 ^* - L1 ^* ) ² + (a2 ^* - a1 ^* ) ² + (b2 ^* - b1 ^* ) ² ) ^1/2 (I)