JP2022026216A - External composition - Google Patents
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- JP2022026216A JP2022026216A JP2020129575A JP2020129575A JP2022026216A JP 2022026216 A JP2022026216 A JP 2022026216A JP 2020129575 A JP2020129575 A JP 2020129575A JP 2020129575 A JP2020129575 A JP 2020129575A JP 2022026216 A JP2022026216 A JP 2022026216A
- Authority
- JP
- Japan
- Prior art keywords
- mass
- external composition
- component
- foam
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000006260 foam Substances 0.000 claims abstract description 123
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 13
- 125000005702 oxyalkylene group Chemical group 0.000 claims abstract description 9
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 25
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、外用組成物等に関する。 The present invention relates to an external composition or the like.
外用剤の剤形として、例えば、軟膏剤、クリーム剤、ローション剤等がある。軟膏剤やクリーム剤は、半固形状であるので、広範囲に塗り広げ難い。また、ローション剤は、液状であるので、広範囲に塗り広げることには向いているが、使用時に液が垂れることがあり使い難い。 Dosage forms of external preparations include, for example, ointments, creams, lotions and the like. Since ointments and creams are semi-solid, it is difficult to spread them over a wide area. In addition, since the lotion is liquid, it is suitable for spreading over a wide area, but it is difficult to use because the liquid may drip during use.
一方、近年、簡便で広範囲に使用可能なフォーム剤が注目されている。フォーム剤は、吐出時は泡状態であるので液垂れが抑制されており、また液体であるので広範囲に塗り広げることにも適している。フォーム剤としては、皮膚への刺激を抑える目的で、非イオン性界面活性剤を用いた、ポンプ型泡吐出装置等の非ガス型泡吐出装置を用いたフォーム剤が望ましい。特許文献１には、非イオン性界面活性剤と一定量以上のアルコールを組合わせることにより、泡を長時間保持することが提案されている。 On the other hand, in recent years, a foaming agent that is simple and can be widely used has attracted attention. Since the foaming agent is in a foamy state at the time of ejection, dripping is suppressed, and since it is a liquid, it is also suitable for spreading over a wide area. As the foaming agent, a foaming agent using a non-gas type foam discharging device such as a pump type foam discharging device using a nonionic surfactant is desirable for the purpose of suppressing irritation to the skin. Patent Document 1 proposes that foam is retained for a long time by combining a nonionic surfactant and a certain amount or more of alcohol.
本発明者は、研究を進める中で、従来技術のフォーム剤は、泡の持続性は良く液垂れは抑制されているものの、塗り広げても泡がなかなか消失せず、塗り広げた部分が白化したように見えるという問題（泡切れが悪いという問題）を有することに着目した。 In the course of research by the present inventor, the foaming agent of the prior art has good foam durability and suppresses dripping, but the foam does not disappear easily even when spread, and the spread portion is whitened. I focused on having the problem that it looks like it was done (the problem that the bubbles are not broken).
そこで、本発明は、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好である、泡吐出装置用の外用組成物を提供することを課題とする。 Therefore, it is an object of the present invention to provide an external composition for a foam ejection device, which has good foaming and foam sustainability, but also has good foam breaking.
本発明者は上記課題に鑑みて鋭意研究を進めた結果、（A1成分）炭素原子数4以上の糖アルコール、及び（B成分）オキシアルキレン単位を含む非イオン性界面活性剤を含有する、泡吐出装置用の外用組成物、であれば、上記課題を解決できることを見出した。本発明者はこの知見に基づいてさらに研究を進めた結果、本発明を完成させた。即ち、本発明は、下記の態様を包含する。 As a result of diligent research in view of the above problems, the present inventor has created a foam containing (A1 component) a sugar alcohol having 4 or more carbon atoms and (B component) a nonionic surfactant containing an oxyalkylene unit. It has been found that the above-mentioned problems can be solved if it is an external composition for a discharge device. The present inventor has completed the present invention as a result of further research based on this finding. That is, the present invention includes the following aspects.
項１． （A1成分）炭素原子数4以上の糖アルコール、及び（B成分）オキシアルキレン単位を含む非イオン性界面活性剤を含有する、泡吐出装置用の外用組成物．
項２． 前記A1成分が炭素原子数4～6の糖アルコールを含む、項１に記載の外用組成物．
項３． 前記A1成分がソルビトール、マンニトール、及びエリスリトールからなる群より選択される少なくとも1種を含む、項１又は２に記載の外用組成物．
項４． 前記外用組成物中の前記A1成分の含有率が0.1～40質量％である、項１～３のいずれかに記載の外用組成物．
項５． さらに、（A2成分）グリセリン、及びグリセリン重合物からなる群より選択される少なくとも1種を含有する、項１～４のいずれかに記載の外用組成物．
項６． 前記外用組成物中の前記A2成分の含有率が0.5～45質量％である、項５に記載の外用組成物．
項７． 前記外用組成物中の1,3-ブチレングリコールの含有率が5質量％未満である、項１～６のいずれかに記載の外用組成物．
項８． 多価アルコール中の前記A1成分と（A2成分）グリセリン、及びグリセリン重合物からなる群より選択される少なくとも1種との合計含有率が80質量％以上である、項１～７のいずれかに記載の外用組成物．
項９． 前記B成分が、オキシエチレン単位及びオキシプロピレン単位からなる群より選択される少なくとも1種を含む非イオン性界面活性剤を含む、項１～８のいずれかに記載の外用組成物．
項１０． 前記B成分が、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、及びポリオキシアルキレンアルキルエーテルからなる群より選択される少なくとも1種を含む、項１～９のいずれかに記載の外用組成物．
項１１． 前記B成分がポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル、及びポリオキシアルキレン硬化ひまし油からなる群より選択される少なくとも1種を含む、項１～１０のいずれかに記載の外用組成物．
項１２． 前記外用組成物中の前記B成分の含有率が0.05～10質量％である、項１～１１のいずれかに記載の外用組成物．
項１３． 界面活性剤中の前記B成分の含有率が80質量％以上である、項１～１２のいずれかに記載の外用組成物．
項１４． 薬効成分を含有する、項１～１３のいずれかに記載の外用組成物．
項１５． 前記薬効成分が、保湿剤、抗炎症剤、ビタミン剤、抗菌剤、及び美白剤からなる群より選択される少なくとも1種である、項１４に記載の外用組成物．
項１６． 前記外用組成物中の水の含有率が25質量％以上である、項１～１５のいずれかに記載の外用組成物．
項１７． 皮膚への塗布に用いるための、項１～１６のいずれかに記載の外用組成物．
項１８． 前記泡吐出装置が非ガス型泡吐出装置である、項１～１７のいずれかに記載の外用組成物．
項１９． 項１～１８のいずれかに記載の外用組成物を泡吐出装置を備える容器に充填してなる、外用剤．
Item 1. An external composition for a foam ejection device containing a sugar alcohol having 4 or more carbon atoms (component A1) and a nonionic surfactant containing (component B) an oxyalkylene unit.
Item 2. Item 2. The external composition according to Item 1, wherein the A1 component contains a sugar alcohol having 4 to 6 carbon atoms.
Item 3. Item 2. The external composition according to Item 1 or 2, wherein the A1 component comprises at least one selected from the group consisting of sorbitol, mannitol, and erythritol.
Item 4. Item 6. The external composition according to any one of Items 1 to 3, wherein the content of the A1 component in the external composition is 0.1 to 40% by mass.
Item 5. Item 4. The external composition according to any one of Items 1 to 4, further comprising at least one selected from the group consisting of (A2 component) glycerin and a glycerin polymer.
Item 6. Item 2. The external composition according to Item 5, wherein the content of the A2 component in the external composition is 0.5 to 45% by mass.
Item 7. Item 6. The external composition according to any one of Items 1 to 6, wherein the content of 1,3-butylene glycol in the external composition is less than 5% by mass.
Item 8. Item 1 to any one of Items 1 to 7, wherein the total content of the A1 component in the polyhydric alcohol and at least one selected from the group consisting of (A2 component) glycerin and a glycerin polymer is 80% by mass or more. The described external composition.
Item 9. Item 6. The external composition according to any one of Items 1 to 8, wherein the component B comprises a nonionic surfactant containing at least one selected from the group consisting of oxyethylene units and oxypropylene units.
Item 10. Items 1 to 9 wherein the component B comprises at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene cured castor oil, and polyoxyalkylene alkyl ether. External composition described in Crab.
Item 11. Item 2. The external composition according to any one of Items 1 to 10, wherein the component B comprises at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, and polyoxyalkylene-cured castor oil. ..
Item 12. Item 2. The external composition according to any one of Items 1 to 11, wherein the content of the component B in the external composition is 0.05 to 10% by mass.
Item 13. Item 6. The external composition according to any one of Items 1 to 12, wherein the content of the component B in the surfactant is 80% by mass or more.
Item 14. Item 6. The external composition according to any one of Items 1 to 13, which contains a medicinal ingredient.
Item 15. Item 2. The external composition according to Item 14, wherein the medicinal ingredient is at least one selected from the group consisting of a moisturizer, an anti-inflammatory agent, a vitamin agent, an antibacterial agent, and a whitening agent.
Item 16. Item 2. The external composition according to any one of Items 1 to 15, wherein the content of water in the external composition is 25% by mass or more.
Item 17. Item 6. The external composition according to any one of Items 1 to 16, which is used for application to the skin.
Item 18. Item 6. The external composition according to any one of Items 1 to 17, wherein the foam discharging device is a non-gas type foam discharging device.
Item 19. An external preparation prepared by filling a container provided with a foam discharge device with the external composition according to any one of Items 1 to 18.
本発明によれば、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好である、泡吐出装置用の外用組成物を提供することができる。 According to the present invention, it is possible to provide an external composition for a foam ejection device, which has good foaming and foam sustainability, but also has good foam breaking.
本明細書中において、「含有」及び「含む」なる表現については、「含有」、「含む」、「実質的にからなる」及び「のみからなる」という概念を含む。 In the present specification, the expressions "contains" and "contains" include the concepts of "contains", "contains", "substantially consists" and "consists of only".
本発明は、その一態様において、（A1成分）炭素原子数4以上の糖アルコール、及び（B成分）オキシアルキレン単位を含む非イオン性界面活性剤を含有する、泡吐出装置用の外用組成物（本明細書において、「本発明の外用組成物」と示すこともある。）に関する。以下、これについて説明する。 In one aspect of the present invention, the present invention is an external composition for a foam ejection device, which comprises (A1 component) a sugar alcohol having 4 or more carbon atoms and (B component) a nonionic surfactant containing an oxyalkylene unit. (In the present specification, it may be referred to as "the external composition of the present invention"). This will be described below.
炭素原子数4以上の糖アルコール（A1成分）は、糖アルコールであって、分子を構成する炭素原子の数が4以上のものである限り、特に制限されない。糖アルコールは、典型的には、アルドースの還元によって生じるもの（アルジトール、好ましくはD－アルジトール）である。糖アルコールの炭素原子数は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは4～7、より好ましくは4～6、さらに好ましくは5～6、よりさらに好ましくは6である。炭素原子数4以上の糖アルコールとしては、例えばエリスリトール、トレイトール等のテトリトール（C4H6（OH）4）； アラビニトール、キシリトール、リビトール等のペンチトール（C5H7（OH）5）； アリトール、イジトール、ガラクチトール、ソルビトール、マンニトール等のヘキシトール（C6H8（OH）6）； ボレミトール、ペルセイトール等のヘプチトール（C7H9（OH）7）等が挙げられる。本発明の一態様において、これらの中でも、泡立ち、泡の持続性、泡切れ等の観点から、好ましくはソルビトール、マンニトール、エリスリトール等が挙げられ、（特に泡の持続性の観点から）より好ましくはソルビトール、マンニトール等が挙げられる。 The sugar alcohol (A1 component) having 4 or more carbon atoms is not particularly limited as long as it is a sugar alcohol and has 4 or more carbon atoms constituting the molecule. Sugar alcohols are typically those produced by the reduction of aldose (alditol, preferably D-alditol). The number of carbon atoms of the sugar alcohol is preferably 4 to 7, more preferably 4 to 6, still more preferably 5 to 6, still more preferably 6 from the viewpoints of foaming, foam sustainability, foam breakage and the like. Examples of sugar alcohols having 4 or more carbon atoms include tetritor such as erythritol and threitol (C 4 H 6 (OH) 4 ); pentitol such as arabinitol, xylitol and ribitol (C 5 H 7 (OH) 5 ); Hexitols such as aritol, iditol, galactitol, sorbitol, and mannitol (C 6 H 8 (OH) 6 ); heptitols such as volemitol and persetol (C 7 H 9 (OH) 7 ) and the like can be mentioned. In one aspect of the present invention, among these, sorbitol, mannitol, erythritol and the like are preferably mentioned from the viewpoint of foaming, foam sustainability, foam breakage and the like, and more preferably (particularly from the viewpoint of foam sustainability). Examples include sorbitol and mannitol.
A1成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The A1 component can be used alone or in combination of any two or more.
本発明の一態様において、A1成分は、炭素原子数4～6の糖アルコールを含むことが好ましい。また、本発明の一態様において、A1成分は、ソルビトール、マンニトール、及びエリスリトールからなる群より選択される少なくとも1種を含むことが好ましい。 In one aspect of the present invention, the A1 component preferably contains a sugar alcohol having 4 to 6 carbon atoms. Further, in one aspect of the present invention, the A1 component preferably contains at least one selected from the group consisting of sorbitol, mannitol, and erythritol.
本発明の外用組成物中のA1成分の含有率は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該含有率は、例えば0.1～40質量％である。該含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは0.2～40質量％、より好ましくは0.4～35質量％、さらに好ましくは0.5～30質量％である。泡立ち、泡の持続性、泡切れ等の観点から、本発明の好ましい一態様において、該含有率の下限は、例えば1質量％、2質量％、3質量％、4質量％、5質量％、6質量％、7質量％、8質量％、9質量％、10質量％であり得る。 The content of the A1 component in the external composition of the present invention is not particularly limited as long as foaming, foam sustainability, and foam breakage can be satisfactorily exhibited. The content is, for example, 0.1 to 40% by mass. The content is preferably 0.2 to 40% by mass, more preferably 0.4 to 35% by mass, and further preferably 0.5 to 30% by mass from the viewpoints of foaming, foam sustainability, foam breakage and the like. From the viewpoint of foaming, foam sustainability, foam breakage, etc., in a preferred embodiment of the present invention, the lower limit of the content is, for example, 1% by mass, 2% by mass, 3% by mass, 4% by mass, 5% by mass, It can be 6% by weight, 7% by weight, 8% by weight, 9% by weight, 10% by weight.
本発明の外用組成物は、泡立ち、泡の持続性、泡切れ等（特に、泡の持続性）の観点から、グリセリン、及びグリセリン重合物からなる群より選択される少なくとも1種（A2成分）を含有することが好ましい。 The external composition of the present invention is at least one selected from the group consisting of glycerin and a glycerin polymer (A2 component) from the viewpoint of foaming, foam persistence, foam breakage, etc. (particularly, foam persistence). Is preferably contained.
グリセリン重合物は、グリセリンが2つ以上重合してなるものであり、その限りにおいて、特に制限されない。グリセリン重合物としては、例えばジグリセリン、ポリグリセリンが挙げられ、泡切れの観点から、好ましくはポリグリセリンが挙げられる。ポリグリセリンのグリセリン重合数は、例えば3～30であり、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは5～20、より好ましくは7～15、さらに好ましくは8～12である。 The glycerin polymer is obtained by polymerizing two or more glycerins, and is not particularly limited as long as it is. Examples of the glycerin polymer include diglycerin and polyglycerin, and from the viewpoint of foam breakage, polyglycerin is preferable. The number of glycerin polymerizations of polyglycerin is, for example, 3 to 30, preferably 5 to 20, more preferably 7 to 15, and even more preferably 8 to 12 from the viewpoint of foaming, foam sustainability, foam breakage, and the like. ..
A2成分としては、泡立ち、泡の持続性、泡切れ等（特に、泡切れ）の観点から、好ましくはグリセリン、ポリグリセリン等が挙げられ、より好ましくはグリセリンが挙げられる。 Examples of the A2 component include glycerin, polyglycerin and the like, and more preferably glycerin, from the viewpoints of foaming, foam sustainability, foam breakage and the like (particularly, foam breakage).
A2成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The A2 component can be used alone or in combination of any two or more.
本発明の一態様において、A2成分は、グリセリン、及びポリグリセリンからなる群より選択される少なくとも1種を含むことが好ましく、グリセリンを含むことがより好ましい。 In one aspect of the present invention, the A2 component preferably contains at least one selected from the group consisting of glycerin and polyglycerin, and more preferably contains glycerin.
本発明の外用組成物がA2成分を含有する場合、本発明の外用組成物中のA2成分の含有率は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該含有率は、例えば0.5～45質量％である。該含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは1～45質量％、より好ましくは2～40質量％、さらに好ましくは4～35質量％、よりさらに好ましくは6～30質量％、とりわけ好ましくは6～25質量％、特に好ましくは8～25質量％である。 When the external composition of the present invention contains an A2 component, the content of the A2 component in the external composition of the present invention is not particularly limited as long as foaming, foam sustainability, and foam breakage can be satisfactorily exhibited. The content is, for example, 0.5 to 45% by mass. The content is preferably 1 to 45% by mass, more preferably 2 to 40% by mass, still more preferably 4 to 35% by mass, still more preferably 6 from the viewpoint of foaming, foam sustainability, foam breakage and the like. It is -30% by mass, particularly preferably 6 to 25% by mass, and particularly preferably 8 to 25% by mass.
本発明の外用組成物がA2成分を含有する場合、本発明の外用組成物中のA1成分とA2成分との合計含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは1～85質量％、より好ましくは2～75質量％、さらに好ましくは4～70質量％、よりさらに好ましくは5～65質量％、とりわけ好ましくは7～55質量％、とりわけさらに好ましくは9～50質量％である。本発明の一態様において、該含有率の下限は、例えば12質量％、14質量％、16質量％、18質量％、又は19質量％であり得る。 When the external composition of the present invention contains an A2 component, the total content of the A1 component and the A2 component in the external composition of the present invention is preferably from the viewpoint of foaming, foam sustainability, foam breakage and the like. 1 to 85% by mass, more preferably 2 to 75% by mass, still more preferably 4 to 70% by mass, still more preferably 5 to 65% by mass, particularly preferably 7 to 55% by mass, and even more preferably 9 to 50%. It is mass%. In one aspect of the invention, the lower limit of the content may be, for example, 12% by weight, 14% by weight, 16% by weight, 18% by weight, or 19% by weight.
本発明の外用組成物がA2成分を含有する場合、本発明の外用組成物中のA1成分とA2成分との含有比は、泡立ち、泡の持続性、泡切れ等の観点から、A1成分1質量部に対して、A2成分が、好ましくは0.05～45質量部、より好ましくは0.1～40質量部、さらに好ましくは0.2～35質量部、よりさらに好ましくは0.3～30質量部である。本発明のさらに好ましい態様において、A1成分1質量部に対して、A2成分は、好ましくは0.4～10質量部、0.5～5質量部、0.6～3質量部、0.8～2質量部である。 When the external composition of the present invention contains an A2 component, the content ratio of the A1 component to the A2 component in the external composition of the present invention is the A1 component 1 from the viewpoint of foaming, foam sustainability, foam breakage, etc. The A2 component is preferably 0.05 to 45 parts by mass, more preferably 0.1 to 40 parts by mass, still more preferably 0.2 to 35 parts by mass, and even more preferably 0.3 to 30 parts by mass with respect to parts by mass. In a more preferable embodiment of the present invention, the A2 component is preferably 0.4 to 10 parts by mass, 0.5 to 5 parts by mass, 0.6 to 3 parts by mass, and 0.8 to 2 parts by mass with respect to 1 part by mass of the A1 component.
本発明の一態様において、本発明の外用組成物は、A1成分及びA2成分以外の他の多価アルコールを含有することができる。他の多価アルコールとしては、例えばプロピレングリコール、ジプロピレングリコール、1,3－ブチレングリコール、1,2－ペンタンジオール、1,2－ヘキサンジオール、1,3,6－ヘキサントリオール、ポリエチレングリコール、ポリプロピレングリコール等が挙げられる。ただ、その場合、泡立ち、泡の持続性、泡切れ等の観点から、他の多価アルコールの含有量はより低いことが好ましい。 In one aspect of the present invention, the external composition of the present invention may contain a polyhydric alcohol other than the A1 component and the A2 component. Other polyhydric alcohols include, for example, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,3,6-hexanetriol, polyethylene glycol, polypropylene. Glycol and the like can be mentioned. However, in that case, it is preferable that the content of the other polyhydric alcohol is lower from the viewpoint of foaming, foam sustainability, foam breakage and the like.
他の多価アルコールは、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 Other polyhydric alcohols can be used alone or in combination of any two or more.
本発明の外用組成物において、多価アルコール中のA1成分とA2成分との合計含有率（本発明の外用組成物がA2成分を含有しない場合は、A1成分の含有率を意味する）は、例えば70質量％以上、好ましくは80質量％以上、より好ましくは85質量％以上、さらに好ましくは90質量％以上、よりさらに好ましくは95質量％以上、とりわけ好ましくは97質量％以上、とりわけさらに好ましくは98質量％、特に好ましくは99質量％以上である。該含有率は、100質量％以下である。 In the external composition of the present invention, the total content of the A1 component and the A2 component in the polyhydric alcohol (when the external composition of the present invention does not contain the A2 component, it means the content of the A1 component). For example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, still more preferably 95% by mass or more, particularly preferably 97% by mass or more, and particularly still more preferable. It is 98% by mass, particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の一態様において、本発明の外用組成物は、泡立ち、泡の持続性、泡切れ等の観点から、他の多価アルコール（例えば、1,3-ブチレングリコール、マクロゴール400、及び1,3,6－ヘキサントリオールからなる群より選択される少なくとも1種の多価アルコール）の含有量がより低いことが好ましい。本発明の外用組成物中の該多価アルコール（一例として、1,3-ブチレングリコール）の含有率は、例えば0質量％以上5質量％未満、好ましくは0質量％以上4質量％未満、より好ましくは0質量％以上3質量％未満、さらに好ましくは0質量％以上2質量％未満、よりさらに好ましくは0質量％以上1質量％未満、とりわけ好ましくは0質量％以上0.5質量％未満、とりわけさらに好ましくは0質量％以上0.1質量％未満、とりわけよりさらに好ましくは0質量％以上0.01質量％未満である。本発明の一態様において、該含有率は、0質量％であることができる。 In one aspect of the invention, the external composition of the invention comprises other polyhydric alcohols (eg, 1,3-butylene glycol, macrogol 400, and 1) in terms of foaming, foam persistence, foam breakage, and the like. , At least one polyhydric alcohol selected from the group consisting of 3,6-hexanetriol) is preferably lower in content. The content of the polyvalent alcohol (for example, 1,3-butylene glycol) in the external composition of the present invention is, for example, 0% by mass or more and less than 5% by mass, preferably 0% by mass or more and less than 4% by mass. It is preferably 0% by mass or more and less than 3% by mass, more preferably 0% by mass or more and less than 2% by mass, still more preferably 0% by mass or more and less than 1% by mass, particularly preferably 0% by mass or more and less than 0.5% by mass, and particularly further. It is preferably 0% by mass or more and less than 0.1% by mass, and more preferably 0% by mass or more and less than 0.01% by mass. In one aspect of the invention, the content can be 0% by weight.
オキシアルキレン単位を含む非イオン性界面活性剤（B成分）は、分子内にオキシアルキレン単位（アルキレンオキサイドの単独重合鎖）を有する非イオン性界面活性剤である限り、特に制限されない。オキシアルキレン単位は、複数個に分かれて存在することができる。「アルキレン」の炭素原子数は、例えば2～4、好ましくは2～3である。オキシアルキレン単位におけるアルキレンオキサイドの平均付加モル数は、特に制限されないが、例えば10～300、好ましくは25～250、より好ましくは35～200である。 The nonionic surfactant (component B) containing an oxyalkylene unit is not particularly limited as long as it is a nonionic surfactant having an oxyalkylene unit (monopolymerized chain of alkylene oxide) in the molecule. The oxyalkylene unit can be divided into a plurality of pieces. The number of carbon atoms of the "alkylene" is, for example, 2 to 4, preferably 2 to 3. The average number of moles of alkylene oxide added in the oxyalkylene unit is not particularly limited, but is, for example, 10 to 300, preferably 25 to 250, and more preferably 35 to 200.
B成分として、泡立ち、泡の持続性、泡切れ等の観点から、オキシエチレン単位及びオキシプロピレン単位からなる群より選択される少なくとも1種を含む非イオン性界面活性剤が好ましい。当該比イオン性界面活性剤は、分子内にオキシエチレン単位（エチレンオキサイドの単独重合鎖）、及び／又はオキシプロピレン単位（プロピレンオキサイドの単独重合鎖）を有する非イオン性界面活性剤である限り、特に制限されない。オキシエチレン単位におけるエチレンオキサイドの平均付加モル数は、特に制限されないが、例えば10～300、好ましくは25～250、より好ましくは35～200である。オキシプロピレン単位におけるプロピレンオキサイドの平均付加モル数は、特に制限されないが、例えば10～300、好ましくは20～200、より好ましくは25～100である。 As the component B, a nonionic surfactant containing at least one selected from the group consisting of oxyethylene units and oxypropylene units is preferable from the viewpoint of foaming, foam sustainability, foam breakage and the like. The specific ionic surfactant is a nonionic surfactant having an oxyethylene unit (polyethylene oxide homopolymerized chain) and / or an oxypropylene unit (propylene oxide homopolymerized chain) in the molecule. There are no particular restrictions. The average number of moles of ethylene oxide added per oxyethylene unit is not particularly limited, but is, for example, 10 to 300, preferably 25 to 250, and more preferably 35 to 200. The average number of moles of propylene oxide added in an oxypropylene unit is not particularly limited, but is, for example, 10 to 300, preferably 20 to 200, and more preferably 25 to 100.
B成分である非イオン性界面活性剤としては、例えばポリオキシエチレンポリオキシプロピレングリコール； ポリオキシエチレン脂肪酸エステル（例えばC12～24、好ましくはC16～20のモノ脂肪酸（飽和又は不飽和脂肪酸）ポリエチレングリコール等）等のポリオキシアルキレン脂肪酸エステル； ポリオキシエチレン硬化ひまし油等のポリオキシアルキレン硬化ひまし油； ポリオキシエチレンラウリルエーテル、ポリオキシエチレンオレイルエーテル、ポリオキシエチレンデシルエーテル、ポリオキアルキレンデシルエーテル等のポリオキアルキレンアルキルエーテル； ポリオキシエチレン硬化ひまし油エーテル等のポリオキシアルキレン硬化ひまし油エーテル； ポリオキシエチレングリセリルエーテル脂肪酸エステル等のポリオキシアルキレングリセリルエーテル脂肪酸エステル； ポリオキシエチレンソルビタン脂肪酸エステル等が挙げられる。これらの中でも、泡立ち、泡の持続性、泡切れ等の観点から、好ましくはポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、ポリオキシアルキレンアルキルエーテル等が挙げられ、より好ましくはポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油等が挙げられる、さらに好ましくはポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル等が挙げられ、よりさらに好ましくはポリオキシエチレンポリオキシプロピレングリコールが挙げられる。 Examples of the nonionic surfactant which is the component B include polyoxyethylene polyoxypropylene glycol; polyoxyethylene fatty acid ester (for example, C12 to 24, preferably C16 to 20 monofatty acid (saturated or unsaturated fatty acid) polyethylene glycol). Etc.), etc. Polyoxyalkylene fatty acid ester; Polyoxyalkylene cured castor oil such as polyoxyethylene hydrogenated castor oil; Examples thereof include alkylene alkyl ether; polyoxyalkylene hydrogenated castor oil ether such as polyoxyethylene hydrogenated castor oil ether; polyoxyalkylene glyceryl ether fatty acid ester such as polyoxyethylene glyceryl ether fatty acid ester; and polyoxyethylene sorbitan fatty acid ester. Among these, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene alkyl ether and the like are preferable from the viewpoints of foaming, foam sustainability, foam breakage and the like. More preferably, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene cured castor oil and the like can be mentioned, and more preferably, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester and the like can be mentioned, and even more. Preferred is polyoxyethylene polyoxypropylene glycol.
B成分である非イオン性界面活性剤のHLB値は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該HLB値は、例えば10～20、好ましくは12～18である。 The HLB value of the nonionic surfactant as the component B is not particularly limited as long as it can satisfactorily exhibit foaming, foam sustainability, and foam breakage. The HLB value is, for example, 10 to 20, preferably 12 to 18.
B成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The B component can be used alone or in combination of any two or more.
本発明の一態様において、B成分は、オキシエチレン単位及びオキシプロピレン単位からなる群より選択される少なくとも1種を含む非イオン性界面活性剤を含むことが好ましい。また、本発明の一態様において、B成分は、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、及びポリオキシアルキレンアルキルエーテルからなる群より選択される少なくとも1種を含むことがより好ましい。また、本発明の一態様において、B成分は、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシアルキレン脂肪酸エステル、及びポリオキシアルキレン硬化ひまし油からなる群より選択される少なくとも1種を含むことがさらに好ましい。 In one aspect of the invention, the component B preferably comprises a nonionic surfactant comprising at least one selected from the group consisting of oxyethylene units and oxypropylene units. Further, in one embodiment of the present invention, the B component is at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene cured castor oil, and polyoxyalkylene alkyl ether. It is more preferable to include it. Further, in one aspect of the present invention, it is more preferable that the component B contains at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, and polyoxyalkylene cured castor oil.
本発明の外用組成物中のB成分の含有率は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該含有率は、例えば0.02～15質量％である。該含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは0.05～12質量％、より好ましくは0.05～10質量％、さらに好ましくは0.1～9質量％、よりさらに好ましくは0.2～9質量％、とりわけ好ましくは0.3～9質量％、とりわけさらに好ましくは0.4～9質量％である。泡立ち、泡の持続性、泡切れ等の観点から、本発明の好ましい一態様において、該含有率の上限は、例えば8質量％、7質量％、6質量％、5質量％、4質量％、3質量％、2質量％、1質量、0.8質量％であり得る。 The content of the component B in the external composition of the present invention is not particularly limited as long as foaming, foam sustainability, and foam breakage can be satisfactorily exhibited. The content is, for example, 0.02 to 15% by mass. The content is preferably 0.05 to 12% by mass, more preferably 0.05 to 10% by mass, still more preferably 0.1 to 9% by mass, still more preferably 0.2, from the viewpoints of foaming, foam sustainability, foam breakage and the like. It is -9% by mass, particularly preferably 0.3-9% by mass, and even more preferably 0.4-9% by mass. From the viewpoint of foaming, foam sustainability, foam breakage, etc., in a preferred embodiment of the present invention, the upper limit of the content is, for example, 8% by mass, 7% by mass, 6% by mass, 5% by mass, 4% by mass, It can be 3% by mass, 2% by mass, 1% by mass, or 0.8% by mass.
本発明の一態様において、本発明の外用組成物は、B成分以外の他の界面活性剤を含有することができる。他の界面活性剤としては、例えばグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、脂肪族アルカノールアミド等の非イオン性界面活性剤； 陰イオン性界面活性剤； 陽イオン性界面活性剤； 両性界面活性剤等が挙げられる。ただ、その場合、皮膚への刺激性、泡立ち、泡の持続性、泡切れ等の観点から、他の界面活性剤の含有量はより低いことが好ましい。 In one aspect of the present invention, the external composition of the present invention may contain a surfactant other than the component B. Examples of other surfactants include nonionic surfactants such as glycerin fatty acid ester, sorbitan fatty acid ester, and aliphatic alkanolamides; anionic surfactants; cationic surfactants; and amphoteric surfactants. Can be mentioned. However, in that case, the content of the other surfactant is preferably lower from the viewpoint of skin irritation, foaming, foam persistence, foam breakage and the like.
他の界面活性剤は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 Other surfactants may be used alone or in combination of any two or more.
本発明の外用組成物において、界面活性剤中のB成分の含有率は、例えば70質量％以上、好ましくは80質量％以上、より好ましくは85質量％以上、さらに好ましくは90質量％以上、よりさらに好ましくは95質量％以上、とりわけ好ましくは97質量％以上、とりわけさらに好ましくは98質量％、特に好ましくは99質量％以上である。該含有率は、100質量％以下である。 In the external composition of the present invention, the content of the B component in the surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more. It is more preferably 95% by mass or more, particularly preferably 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の外用組成物において、非イオン性界面活性剤中のB成分の含有率は、例えば70質量％以上、好ましくは80質量％以上、より好ましくは85質量％以上、さらに好ましくは90質量％以上、よりさらに好ましくは95質量％以上、とりわけ好ましくは97質量％以上、とりわけさらに好ましくは98質量％、特に好ましくは99質量％以上である。該含有率は、100質量％以下である。 In the external composition of the present invention, the content of the component B in the nonionic surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass. As described above, it is more preferably 95% by mass or more, particularly preferably 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の外用組成物中の他の界面活性剤（特に、陰イオン性界面活性剤、陽イオン性界面活性剤、及び両性界面活性剤）の含有率は、例えば0質量％以上5質量％未満、好ましくは0質量％以上4質量％未満、より好ましくは0質量％以上3質量％未満、さらに好ましくは0質量％以上2質量％未満、よりさらに好ましくは0質量％以上1質量％未満、とりわけ好ましくは0質量％以上0.5質量％未満、とりわけさらに好ましくは0質量％以上0.1質量％未満、とりわけよりさらに好ましくは0質量％以上0.01質量％未満である。本発明の一態様において、該含有率は、0質量％であることができる。 The content of other surfactants (particularly, anionic surfactants, cationic surfactants, and amphoteric surfactants) in the external composition of the present invention is, for example, 0% by mass or more and less than 5% by mass. , Preferably 0% by mass or more and less than 4% by mass, more preferably 0% by mass or more and less than 3% by mass, further preferably 0% by mass or more and less than 2% by mass, still more preferably 0% by mass or more and less than 1% by mass, in particular. It is preferably 0% by mass or more and less than 0.5% by mass, more preferably 0% by mass or more and less than 0.1% by mass, and even more preferably 0% by mass or more and less than 0.01% by mass. In one aspect of the invention, the content can be 0% by weight.
本発明の一態様において、本発明の外用組成物は、薬効成分を含有することができる。薬効成分は、水溶性薬効成分であることが好ましい。薬効成分としては、例えば、保湿剤、抗炎症剤、ビタミン剤、抗菌剤、美白剤等が挙げられる。 In one aspect of the present invention, the external composition of the present invention can contain a medicinal ingredient. The medicinal ingredient is preferably a water-soluble medicinal ingredient. Examples of the medicinal ingredient include moisturizers, anti-inflammatory agents, vitamin agents, antibacterial agents, whitening agents and the like.
保湿剤としては、例えば、ヘパリン類似物質、ヘパリン又はその塩、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、ケラチン等の生体高分子； グリシン、アスパラギン酸、アルギニン等のアミノ酸； 乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム等の天然保湿因子； ラベンダーエキス、ユーカリエキス、ペパーミントエキス等の植物抽出物等が挙げられる。 Moisturizers include, for example, heparin-like substances, heparin or salts thereof, biopolymers such as sodium hyaluronate, chondroitin sulfate, collagen, elastin, keratin; amino acids such as glycine, aspartic acid, arginine; sodium lactate, urea, etc. Natural moisturizing factors such as sodium pyrrolidone carboxylate; plant extracts such as lavender extract, eucalyptus extract, peppermint extract and the like can be mentioned.
抗炎症剤としては、例えば、グリチルリチン酸、グリチルリチン酸二カリウム、グリチルリチン酸モノアンモニウム等のグリチルリチン酸誘導体、グリチルレチン酸又はその誘導体、アラントイン又はその誘導体、トラネキサム酸又はその塩、ε－アミノカプロン酸、カンゾウ抽出物、メントール、カンフル等が挙げられる。
ビタミン剤としては、例えば、アスコルビン酸及びそのナトリウム等の塩等のビタミンC類； アスコルビン酸エチルエーテル等のアスコルビン酸アルキルエーテル、アスコルビン酸－2－グルコシド等のアスコルビン酸グルコシド及びその脂肪酸エステ
ル、アスコルビン酸リン酸エステルナトリウム塩及びアスコルビン酸リン酸エステルマグネシウム塩、パルミトイルアスコルビン酸リン酸エステルナトリウム塩、リン酸トコフェリルアスコルビル等のアスコルビン酸リン酸エステル塩等のアスコルビン酸誘導体； チアミン塩酸塩、チアミン硫酸塩、リボフラビン、酢酸リボフラビン、塩酸ピリドキシン、フラビンアデニンジヌクレオチド、シアノコバラミン、葉酸類、ニコチン酸、ニコチン酸アミド等のニコチン酸類、コリン類等のビタミンB群類； パントテン酸、パンテニルエチルエーテル、パンテノール、ビオチン等のその他ビタミン類； トコフェロールリン酸エステル等の水溶性ビタミンE類等が挙げられる。
Examples of the anti-inflammatory agent include glycyrrhizic acid derivatives such as glycyrrhizic acid, dipotassium glycyrrhizinate, and monoammonium glycyrrhizinate, glycyrrhizic acid or its derivatives, allantin or its derivatives, tranexamic acid or its salts, ε-aminocaproic acid, and licorice extraction. Things, menthol, licorice, etc. can be mentioned.
Examples of the vitamin preparation include vitamin Cs such as ascorbic acid and salts such as sodium thereof; ascorbic acid alkyl ether such as ethyl ether ascorbic acid, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid ester, ascorbic acid. Ascorbic acid derivatives such as sodium phosphate and ascorbic acid phosphate magnesium salts, palmitoyl ascorbic acid phosphate sodium salts, ascorbic acid phosphate ester salts such as tocopheryl phosphate ascorbyl; thiamine hydrochloride, thiamine sulfate, Riboflavin, riboflavin acetate, pyridoxin hydrochloride, flavin adenine dinucleotide, cyanocobalamine, folic acid, nicotinic acid, nicotinic acid such as nicotinic acid amide, vitamin B group such as choline; pantothenic acid, pantenyl ethyl ether, pantenol, biotin Other vitamins such as; water-soluble vitamin Es such as tocopherol phosphate ester and the like.
抗菌剤としては、例えば、イソプロピルメチルフェノール、塩酸クロルヘキシジン、塩化ベンザルコニウム、塩化セチルピリジニウム、エタノール、パラベン、フェノキシエタノール等が挙げられる。 Examples of the antibacterial agent include isopropylmethylphenol, chlorhexidine hydrochloride, benzalkonium chloride, cetylpyridinium chloride, ethanol, paraben, phenoxyethanol and the like.
美白剤としては、例えば、ハイドロキノン、α－アルブチン、β－アルブチン、アスコルビン酸、2－O－エチルアスコルビン酸、3－O－エチルアスコルビン酸、3－O－セチルアスコルビン酸、テトラ2－ヘキシルデシルデカン酸アスコルビル、アスコルビン酸メチルシラノール、アスコルビン酸硫酸、アスコルビルグルコシド、（アスコルビル／トコフェリル）リン酸カリウム、アスコルビルリン酸、パルミチン酸アスコルビル、ジパルミチン酸アスコルビル、パルミチン酸アスコルビルリン酸3ナトリウム、リン酸アスコルビルアミノプロピル、ステアリン酸アスコルビル、デヒドロアスコルビン酸、アスコルビン酸硫酸2ナトリウム、アスコルビン酸カルシウム、アスコルビン酸マグネシウム、アスコルビン酸ナトリウム、アスコルビン酸亜鉛、キトサンアスコルビン酸、アスコルビルリン酸ナトリウム、リン酸アスコルビルマグネシウム、リン酸アスコルビル3ナトリウム、コウジ酸、ルシノール、トラネキサム酸等が挙げられる。 Examples of the whitening agent include hydroquinone, α-albutin, β-albutin, ascorbyl palmitate, 2-O-ethylascorbyl palmitate, 3-O-ethylascorbyl palmitate, 3-O-cetyl ascorbyl palmitate, and tetra2-hexyl decyldecane. Ascorbyl acid, methylsilanol ascorbyl, sulfuric acid ascorbyl, ascorbyl glucoside, (ascorbyl / tocoferyl) potassium phosphate, ascorbyl phosphate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl palmitate 3 sodium, ascorbyl palmitate aminopropyl , Ascorbyl steitate, dehydroascorbyl acid, disocorbyl palmitate disodium, calcium ascorbyl acid, magnesium ascorbyl acid, sodium ascorbyl acid, zinc ascorbyl acid, chitosan ascorbyl acid, sodium ascorbyl phosphate, ascorbyl magnesium phosphate, ascorbyl 3 sodium phosphate , Ascorbyl palmitate, ascorbyl palmit, tranexamic acid and the like.
薬効成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The medicinal ingredient may be used alone or in combination of any two or more.
本発明の外用組成物が薬効成分を含有する場合、本発明の外用組成物中の薬効成分の含有率は、薬効を発揮することができ、且つ泡立ち、泡の持続性、泡切れ等を著しく阻害しない限りにおいて、特に制限されない。該含有率は、例えば、0.0001～10質量％、0.001～3質量％、又は0.01～1質量％である。 When the external composition of the present invention contains a medicinal ingredient, the content of the medicinal ingredient in the external composition of the present invention is capable of exerting the medicinal effect, and remarkably causes foaming, foam persistence, foam breakage and the like. As long as it does not inhibit, there is no particular limitation. The content is, for example, 0.0001 to 10% by mass, 0.001 to 3% by mass, or 0.01 to 1% by mass.
本発明の一態様において、本発明の外用組成物は、上記以外の他の成分を含有することができる。他の成分としては、例えば、エステル油類（例えば、トリアセチン、クエン酸トリエチル、トリ（カプリル、カプリン酸）グリセリン、アジピン酸ジイソプロピル、アジピン酸ジエチル、セバシン酸ジエチル等の二塩基酸、ミリスチン酸イソプロピル、パルミチン酸セチル、ラウリン酸ヘキシル、酢酸ベンジル等の一塩基酸等）、炭化水素類（例えば、流動パラフィン、スクワラン等）、溶剤（例えば、ベンジルアルコール、メチルエチルケトン、N－アルキルピロリドン、アルキレンカーボネート、アセトン、エタノール、イソプロパノール、プロピレングリコール、1,3－ブチレングリコール等）、水溶性高分子（例えば、カルボキシビニルポリマー、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、キトサン、ポビドン、ポリビニルアルコール等）、防腐剤、保存剤、安定化剤等が挙げられる。 In one aspect of the present invention, the external composition of the present invention may contain other components other than the above. Other components include, for example, ester oils (eg, triacetin, triethyl citrate, tri (capryl, capric acid) glycerin, diisopropyl adipate, diethyl adipate, diethyl dibasic acid such as diethyl sebacate, isopropyl myristate, etc. Cetyl palmitate, hexyl laurate, monobasic acids such as benzyl acetate, etc.), hydrocarbons (eg, liquid paraffin, squalane, etc.), solvents (eg, benzyl alcohol, methyl ethyl ketone, N-alkylpyrrolidone, alkylene carbonate, acetone, etc.) Ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, etc.), water-soluble polymers (eg, carboxyvinyl polymer, hydroxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, chitosan, povidone, polyvinyl alcohol, etc.), preservatives, preservatives , Stabilizers and the like.
本発明の外用組成物中の他の成分の含有率は、泡立ち、泡の持続性、泡切れ等を著しく阻害しない限りにおいて、特に制限されない。該含有率は、例えば、0～10質量％、0～5質量％、0～2質量％、0～1質量％、又は0～0.1質量％である。 The content of other components in the external composition of the present invention is not particularly limited as long as it does not significantly impair foaming, foam persistence, foam breakage and the like. The content is, for example, 0 to 10% by mass, 0 to 5% by mass, 0 to 2% by mass, 0 to 1% by mass, or 0 to 0.1% by mass.
本発明の外用組成物は、泡立ち、泡の持続性、泡切れ等の観点から、通常、水を含有する。本発明の組成物中の水の含有率は、例えば15質量％以上、好ましくは20質量％以上、より好ましくは25質量％以上、さらに好ましくは30質量％以上、よりさらに好ましくは35質量％以上、とりわけ好ましくは40質量％以上、とりわけさらに好ましくは50質量％以上、とりわけよりさらに好ましくは60質量％以上である。該含有率の上限は、例えば95質量％、90質量％、85質量％、又は80質量％であることができる。上記下限及び上限は、任意に組合わせることができる。 The external composition of the present invention usually contains water from the viewpoints of foaming, foam sustainability, foam breakage and the like. The content of water in the composition of the present invention is, for example, 15% by mass or more, preferably 20% by mass or more, more preferably 25% by mass or more, still more preferably 30% by mass or more, still more preferably 35% by mass or more. , Particularly preferably 40% by mass or more, particularly preferably 50% by mass or more, and even more preferably 60% by mass or more. The upper limit of the content can be, for example, 95% by mass, 90% by mass, 85% by mass, or 80% by mass. The above lower limit and upper limit can be arbitrarily combined.
本発明の外用組成物は、皮膚への塗布に用いることができる。本発明の外用組成物は、泡の持続性が良好であるので、泡状で吐出した際の液垂れを抑制しつつ、泡切れも良好であるので、容易に塗り広げることができる。本発明の外用組成物は、皮膚外用医薬、化粧料等の皮膚外用組成物の形態であることが好ましい。本発明の外用組成物は、塗布後に除去しない態様で用いられるものであり、泡立て使用した後に水で除去（例えば洗い流す）ことを目的とした洗浄剤とは区別されるものである。 The external composition of the present invention can be used for application to the skin. Since the composition for external use of the present invention has good foam durability, it can be easily spread because it suppresses dripping when discharged in the form of foam and also has good foam breakage. The external composition of the present invention is preferably in the form of an external composition for skin such as a medicine for external skin and cosmetics. The external composition of the present invention is used in such a manner that it is not removed after application, and is distinguished from a cleaning agent intended to be removed (for example, washed away) with water after being used by whipping.
本発明の外用組成物は、各成分を溶媒と共に混合することにより調製することができる。本発明の組成物は、好ましくは可溶化状態である。可溶化状態とは、界面活性剤がミセルを形成し、溶媒に溶解しない物質が透明かつ均一に溶解し、一相の溶液となっている状態をいう。また、可溶化状態は、マイクロエマルションの状態を含む。マイクロエマルションは、100nm以下の微細な粒子径の乳化粒からなり、熱力学的に安定なミセル溶液である。可溶化状態であることは、外観が透明であることをもって確認できる。また、常法により、粒子サイズを測定することにより可溶化状態を確認することもできる。可溶化状態の組成物は、必要に応じて各成分を加温下で溶解して、その後冷却することにより得ることが可能である。 The external composition of the present invention can be prepared by mixing each component with a solvent. The composition of the present invention is preferably in a solubilized state. The solubilized state means a state in which the surfactant forms micelles and the substance insoluble in the solvent is transparently and uniformly dissolved to form a one-phase solution. The solubilized state includes the state of a microemulsion. The microemulsion is a thermodynamically stable micelle solution composed of emulsified particles having a fine particle size of 100 nm or less. The solubilized state can be confirmed by the transparent appearance. In addition, the solubilized state can be confirmed by measuring the particle size by a conventional method. The solubilized composition can be obtained by dissolving each component under heating, if necessary, and then cooling.
本発明の外用組成物は、泡吐出装置用の組成物である。ここで、泡吐出装置とは、発泡させる機構を備えるものを意味する。すなわち、本発明の外用組成物は、泡吐出装置により発泡して用いるためのものである。泡吐出装置としては、皮膚への刺激の観点から、非ガス型泡吐出装置であることが好ましい。非ガス型泡吐出装置としては、例えばスクリーン型泡吐出装置が挙げられる。スクリーン型泡吐出装置とは、液体を加圧し、ネット状のスクリーンを通過させることにより、空気と混合せしめ、発泡させる機構のものを意味する。スクリーン型泡吐出装置としては、例えばポンプ型泡吐出装置、チューブ型泡吐出装置、スクイズ型泡吐出装置等が挙げられる。これらの中でも、ポンプ型泡吐出装置が好適である。 The external composition of the present invention is a composition for a foam ejection device. Here, the foam discharge device means a device provided with a mechanism for foaming. That is, the external composition of the present invention is intended to be foamed and used by a foam ejection device. The foam ejection device is preferably a non-gas type foam ejection device from the viewpoint of irritation to the skin. Examples of the non-gas type foam discharge device include a screen type foam discharge device. The screen-type foam ejection device means a mechanism that pressurizes a liquid, passes it through a net-like screen, mixes it with air, and foams it. Examples of the screen type foam discharge device include a pump type foam discharge device, a tube type foam discharge device, a squeeze type foam discharge device, and the like. Among these, the pump type foam discharge device is suitable.
泡吐出装置としては、公知のもの、市販されているもの等を採用することができる。例えばポンプ型泡吐出装置であれば、特開2012－45525号公報、特開2008－307478号公報等に記載のものを使用することができる。 As the foam discharge device, a known one, a commercially available one, or the like can be adopted. For example, in the case of a pump-type foam discharge device, those described in JP-A-2012-45525, JP-A-2008-307478 and the like can be used.
本発明の外用組成物は、泡吐出装置を備える容器に充填して用いることができる。この観点から、本発明は、その一態様において、本発明の外用組成物を泡吐出装置を備える容器に充填してなる、外用剤、にも関する。「外用剤」については、上記した本発明の外用組成物と同様である。 The external composition of the present invention can be used by filling a container equipped with a foam ejection device. From this point of view, the present invention also relates to, in one aspect, an external preparation, which comprises filling a container provided with a foam ejection device with the external composition of the present invention. The “external agent” is the same as the above-mentioned external composition of the present invention.
以下に、実施例に基づいて本発明を詳細に説明するが、本発明はこれらの実施例によって限定されるものではない。 Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited to these examples.
試験例1．泡の評価試験1
表１及び表２（数字の単位は質量部）に示す処方に従って、泡吐出装置を備える容器への充填用の組成物1～16を調製した。具体的には、各成分をそれぞれ秤量し、80℃で加熱溶解して攪拌下で可溶化させた後、室温まで攪拌しながら冷却して組成物1～16を得た。これらの組成物をポンプ型泡吐出装置容器に充填し、試験に供した。
Test example 1. Foam evaluation test 1
Compositions 1 to 16 for filling a container equipped with a foam ejection device were prepared according to the formulations shown in Tables 1 and 2 (numerical units are parts by mass). Specifically, each component was weighed, dissolved by heating at 80 ° C., solubilized under stirring, and then cooled to room temperature with stirring to obtain compositions 1 to 16. These compositions were filled in a pump-type foam discharger container and subjected to a test.
使用した材料の詳細は以下の通りである。
・70％Dソルビトール液（D-ソルビトール（富士フィルム和光純薬社製、商品名：D-ソルビトール（和光一級））を精製水に溶かして製造した）
・マンニトール（富士フィルム和光純薬社製、商品名：D-マンニトール（和光特級））
・エリスリトール（東京化成工業社製、商品名：meso-エリスリトール）
・グリセリン（富士フィルム和光純薬社製、商品名：グリセリン（試薬特級））
・ポリグリセリン（阪本薬品工業社製、商品名：ポリグリセリン750、グリセリン重合数：10）
・ポリオキシエチレンポリオキシプロピレングリコール（日油社製、商品名：プロノン188P）
・モノステアリン酸ポリエチレングリコール（日光ケミカルズ社製、商品名：MYS-40MV）
・ポリオキシエチレン硬化ひまし油（日光ケミカルズ社製、商品名：HCO-60（医薬品））。
The details of the materials used are as follows.
・ 70% D-sorbitol solution (manufactured by dissolving D-sorbitol (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., trade name: D-sorbitol (Wako first grade)) in purified water)
・ Mannitol (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., product name: D-mannitol (Wako special grade))
・ Erythritol (manufactured by Tokyo Chemical Industry Co., Ltd., product name: meso-erythritol)
・ Glycerin (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., product name: glycerin (special grade reagent))
・ Polyglycerin (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd., trade name: polyglycerin 750, number of glycerin polymerizations: 10)
-Polyoxyethylene polyoxypropylene glycol (manufactured by NOF Corporation, trade name: Pronon 188P)
・ Polyethylene glycol monostearate (manufactured by Nikko Chemicals, trade name: MYS-40MV)
-Polyoxyethylene hydrogenated castor oil (manufactured by Nikko Chemicals, trade name: HCO-60 (pharmaceutical product)).
ポンプ型泡吐出装置容器から組成物1～16それぞれをスライドガラス上に一定量吐出させた。吐出直後の泡立ちを、目視により観察し、以下の評価基準に従って4段階で評価した。また、泡の持続性を、吐出から5分間静置させた後の泡の状態の変化を目視により観察して、以下の評価基準に従って4段階で評価した。吐出直後の泡立ちについては、○以上の評価を泡立ち良好と判断し、泡の持続性については△以上の評価を持続性良好と判断した。 A fixed amount of each of the compositions 1 to 16 was discharged onto the slide glass from the pump-type foam discharge device container. Foaming immediately after discharge was visually observed and evaluated on a 4-point scale according to the following evaluation criteria. In addition, the sustainability of the foam was evaluated on a 4-point scale according to the following evaluation criteria by visually observing the change in the state of the foam after allowing it to stand for 5 minutes from the discharge. Regarding the foaming immediately after discharge, the evaluation of ◯ or higher was judged to be good foaming, and the evaluation of foam sustainability of Δ or higher was judged to be good sustainability.
＜吐出直後の泡立ちの評価基準＞
◎：泡質の良い（きめが細かい、泡が立つ）泡立ち。
○：泡立つ。
△：泡立ちが弱い。
×：泡にならない。
<Evaluation criteria for foaming immediately after ejection>
◎: Foaming with good foam quality (fine texture, foaming).
◯: Foams.
Δ: Weak foaming.
×: Does not form bubbles.
＜泡の持続性の評価基準＞
◎：泡に変化が認められない。
○：泡高さが低くなる。
△：スライドガラス上で泡が占める面積が小さくなる。
×：泡がなくなる。
<Evaluation criteria for foam sustainability>
⊚: No change is observed in the bubbles.
◯: The bubble height becomes low.
Δ: The area occupied by bubbles on the slide glass becomes smaller.
X: There are no bubbles.
一方で、ポンプ型泡吐出装置容器から組成物1～16それぞれを被検者の片方の腕に一定量吐出させ、指先に向けて塗り広げた。ただし、塗り広げる動作は1回のみとした。泡切れを、以下の評価基準に従って3段階で評価した。△以上の評価を泡切れ良好と判断した。 On the other hand, a certain amount of each of the compositions 1 to 16 was discharged from the pump-type foam discharger container to one arm of the subject and spread toward the fingertips. However, the spreading operation was performed only once. Foam breakage was evaluated on a three-point scale according to the following evaluation criteria. Δ The above evaluation was judged to be good for foam breakage.
＜泡切れの評価基準＞
○：1回塗り広げた後、腕に泡残りが認められたが、泡は1分以内に消失した。
△：1回塗り広げた後、腕に泡残りが認められ、泡は1分経過後も残っていた。ただ、何度も塗り広げることにより、泡は消え、白化も認められなかった。
×：1回塗り広げた後、腕に泡残りが認められ、それから何度も塗り広げたが泡が残り、腕に白化が認められた。
<Evaluation criteria for bubble breakage>
◯: After spreading once, foam remained on the arm, but the foam disappeared within 1 minute.
Δ: After spreading once, foam remained on the arm, and the foam remained even after 1 minute had passed. However, by spreading it many times, the bubbles disappeared and no whitening was observed.
X: After spreading once, foam remained on the arm, and then after spreading many times, foam remained and whitening was observed on the arm.
結果を表１及び表２に示す。 The results are shown in Tables 1 and 2.
表１及び表２の通り、組成物1～16から得られる泡は、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好であった。 As shown in Tables 1 and 2, the foams obtained from the compositions 1 to 16 had good foaming and foam sustainability, but also had good foam breakage.
試験例2．泡の評価試験2
表３（数字の単位は質量部）に示す処方に従って、泡吐出装置を備える容器への充填用の組成物17～18を、試験例1と同様にして調製した。吐出直後の泡立ち、泡の持続性、及び泡切れを、試験例1と同様にして評価した。
Test example 2. Foam evaluation test 2
Compositions 17 to 18 for filling a container equipped with a foam ejection device were prepared in the same manner as in Test Example 1 according to the formulation shown in Table 3 (the unit of numbers is parts by mass). Foaming immediately after ejection, foam persistence, and foam breakage were evaluated in the same manner as in Test Example 1.
結果を表３に示す。 The results are shown in Table 3.
表３の通り、組成物17～18から得られる泡は、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好であった。 As shown in Table 3, the foams obtained from the compositions 17 to 18 had good foaming and foam sustainability, but also had good foam breakage.
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