JP2021161034A - Skin flora balance improver - Google Patents

Abstract

To provide a skin flora balance improver that has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus.SOLUTION: A lanolin fatty acid or a salt thereof is used. The lanolin fatty acid or the salt thereof has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. Therefore, it can be preferably used as an active ingredient of a skin flora balance improver. The skin flora balance improver of the present invention is effective in improving rough skin and atopic dermatitis.SELECTED DRAWING: None

Description

The present invention relates to a skin flora balance improving agent containing a lanolin fatty acid or a salt thereof as an active ingredient.

A wide variety of microorganisms called indigenous skin flora inhabit human skin and play a part in maintaining the health of the skin. Staphylococcus epidermidis is known as a major indigenous bacterium on the skin. Staphylococcus epidermidis decomposes sebum to produce glycerin and fatty acids, thereby preventing the skin from drying out and adjusting the pH to suppress the growth of germs. It has also been reported to have an effect of promoting the production of antibacterial peptides. Thus, Staphylococcus epidermidis is known as a good bacterium that maintains the health of the skin. On the other hand, Staphylococcus aureus is also a bacterium that is resident on the skin, but it is known as a bad bacterium with strong pathogenicity. In healthy skin, normal biological defense functions do not cause problems, but it is known that the growth of Staphylococcus aureus for some reason causes skin diseases. For example, it has been reported that in rough skin, Staphylococcus epidermidis decreases and Staphylococcus aureus increases, and the balance between Staphylococcus epidermidis and Staphylococcus aureus is out of balance compared to normal. ing. In particular, in atopic dermatitis, it has been reported that Staphylococcus epidermidis is greatly reduced and Staphylococcus aureus predominates in the inflamed area. Therefore, in order to prevent or improve these symptoms, it is considered effective to improve the balance between Staphylococcus epidermidis and Staphylococcus aureus.

Patent Documents 1 and 2 describe that a specific fatty acid or a salt thereof has antibacterial activity against Staphylococcus aureus. However, although it is described that these fatty acids do not show antibacterial properties against Staphylococcus epidermidis, the effect of growing Staphylococcus epidermidis has not been confirmed.

Japanese Unexamined Patent Publication No. 2006-206582 Japanese Unexamined Patent Publication No. 2012-144453

An object of the present invention is to provide a skin flora balance improving agent having a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus.

As a result of studies to solve the above problems, the present inventors have found that lanolin fatty acid or a salt thereof has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. , The present invention has been completed. That is, the present invention provides a skin flora balance improving agent containing a lanolin fatty acid or a salt thereof as an active ingredient.

The skin flora balance improving agent of the present invention has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. Therefore, it can be preferably used as a skin flora balance improving agent.

The present invention relates to a skin flora balance improving agent containing a lanolin fatty acid or a salt thereof as an active ingredient.

The lanolin fatty acid used in the present invention is a fatty acid obtained by hydrolyzing wool fat secreted on the surface of sheep's hair. The wool fat may be used as it is, but lanolin obtained by further purifying the wool fat by filtration, decolorization, deodorization, dehydration, solvent extraction, centrifugation, distillation or the like may be used. As the lanolin, commercially available purified lanolin, liquid lanolin, hard lanolin, reduced lanolin, adsorption-purified lanolin and the like can be used.

The method for hydrolyzing wool fat or lanolin is not particularly limited, and a known method can be used, but it can be obtained, for example, by hydrolysis with an alkali. As the alkali used, sodium hydroxide, potassium hydroxide and the like are generally used, but other alkalis may be used. Alternatively, it may be hydrolyzed with an acid such as hydrochloric acid, sulfuric acid or phosphoric acid. The desired lanolin fatty acid can be obtained by separating the hydrolyzed wool fat or lanolin by solvent extraction or the like and neutralizing the soap portion of the fatty acid with an acid to obtain a free fatty acid. The main components of the lanolin fatty acid thus obtained are approximately 7% by mass of normal fatty acid, 22% by mass of iso fatty acid, 29% by mass of anteiso fatty acid, 25% by mass of α-hydroxynormal fatty acid, and 3% by mass of α-hydroxyisofatty acid. It consists of 1% by mass of α-hydroxyanteiso fatty acid, 3% by mass of ω-hydroxynormal fatty acid, 1% by mass of ω-hydroxyisofatty acid, 1% by mass of ω-hydroxyantiisofatty acid, and has 9 to 33 carbon atoms. It is a fatty acid with a very complex composition with a wide distribution. Examples of the lanolin fatty acid include soft lanolin fatty acid and hard lanolin fatty acid whose composition is changed by operations such as solvent separation and distillation. In the present invention, any lanolin fatty acid can be used, but from the viewpoint of economy. Lanolin fatty acid or soft lanolin fatty acid is preferable, and soft lanolin fatty acid is more preferable from the viewpoint of further exerting the effect of the present invention. The soft lanolin fatty acid is a product obtained by hydrolyzing liquid lanolin or a relatively low molecular weight component extracted from the lanolin fatty acid by an operation such as solvent extraction, centrifugation, or distillation, and has a melting point of about 35 to 55 ° C. Lanolin fatty acid. Further, as the soft lanolin fatty acid, the method described in JP-A-6-234994, specifically, the ester of the lower alcohol of the lanolin fatty acid or the lanolin fatty acid is treated with boric acid to obtain the hydroxy fatty acid in the lanolin fatty acid as the boric acid ester. Next, the non-hydroxy fatty acid of the lanolin fatty acid obtained by the method of molecularly distilling and separating it as a distillate, or the method of heat-treating the lanolin fatty acid to lactide the hydroxy fatty acid in the lanolin fatty acid and then molecularly distilling and separating it as a distillate. Lanorin fatty acid containing a large amount of components (Ecolano FA-NH is commercially available from Nippon Seika Co., Ltd. as a commercial product) can also be preferably used. Further, as the soft lanolin fatty acid, a lanolin fatty acid in which the content of 18-methyleicosanoic acid is increased by a method such as molecular distillation can also be preferably used.

Since the lanolin fatty acid used in the present invention can exert its effect even in the form of a salt, it may be used as a salt. Examples of the salt of the arginine amino acid used in the present invention include the above-mentioned arginine amino acid, Li, Na, K, Ca, Ba, Mg, Al, Fe, Co, Zn, Ti, Sn, Pb, Cu, Ag, Au and the like. Salts with metals; Salts with basic amino acids such as lysine, arginine, histidine, ornithine; Salts with nitrogen-containing bases such as ammonium, triethylamine, monoethanolamine, diethanolamine, triethanolamine, pyridine, imidazole, guanidine And so on. Of these, salts with metals selected from Na, K, Ca, Mg, Al and Zn; salts with basic amino acids selected from lysine, arginine, histidine and ornithine; ammonium, triethanolamine and guanidine. Salts with nitrogen-containing bases selected from are preferred, with salts with Na, K, Ca, Zn, ammonium, triethanolamine, arginine or guanidine being more preferred. The salts of these lanolin fatty acids may be used alone or in combination of two or more.

The lanolin fatty acid of the present invention or a salt thereof has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus, as shown in Examples described later. Therefore, it can be used as an active ingredient of an agent for improving the balance of indigenous bacteria on the skin. The skin indigenous bacterium balance improving agent of the present invention may consist of the active ingredient itself, or in addition to the active ingredient, general bases such as water, gel, polyhydric alcohol, petrolatum, paraffin, etc. It may be dissolved, dispersed or mixed in vegetable oil, silicone oil or the like. In addition, various additives can be used in combination as needed. The additives that can be used are not particularly limited as long as they are usually used to obtain a desired dosage form, and are excipients, colorants, thickeners, binders, disintegrants, dispersants, and stabilizers. , Gelling agents, antioxidants, surfactants, preservatives, moisturizers, pH adjusters and the like may be appropriately selected and used.

Examples of the method for administering the indigenous skin flora balance improving agent containing the lanolin fatty acid of the present invention or a salt thereof as an active ingredient to a living body include oral administration, injection, transdermal administration, and the like, but transdermal administration is preferable. Administration. The dose may be any amount as long as the effect of the present invention can be obtained, and is not particularly limited, and may be appropriately adjusted according to the dosage form, application site, age, sex, etc. of the preparation. In addition, as an active ingredient that exerts a desired effect, it may be blended and administered as one component of a pharmaceutical product. In the case of pharmaceuticals, oral preparations such as tablets, capsules, granules, powders, liquids and suspensions; external preparations such as dermatological agents, patches, eye drops, nasal drops, oral preparations and suppositories; It can be added to parenteral preparations such as drugs and injections.

The lanolin fatty acid or a salt thereof used in the present invention can be preferably used as an active ingredient for improving the balance of indigenous bacteria on the skin and as a component for cosmetics or external skin preparations. The amount of the lanolin fatty acid or salt thereof of the present invention to be blended in cosmetics or external skin preparations is not particularly limited, and is usually 0.01 to 30.0% by weight, preferably 0.05 to 20.0% by weight. be.

The cosmetics or skin external preparations of the present invention include additive components such as oily bases, moisturizers / feel improvers, surfactants, polymers / thickening / thickening agents, which are added to water and ordinary cosmetics as needed. Gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant / animal / microbial extracts, UV absorbers, antibacterial / preservatives, chelating agents, pH adjustment Agents / acids / alkalis, solvents / propellants, antipruritic agents, keratin exfoliating / dissolving agents, antiperspirants, refreshing agents, astringents, enzymes, nucleic acids, anti-inflammatory agents / anti-inflammatory agents, hair growth agents / promoting blood circulation Agents / stimulants, hormones, anti-wrinkle / anti-aging agents, irritation relievers, cold sensitizers, warming agents, powders, pigments / colorants / dyes / pigments, fragrances, etc. do not impair the effects of the present invention. It may be contained in a degree.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, chimil alcohol, seraquil alcohol, bacil alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylene acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, Higher fatty acids such as hydrogenated dimer acid and metal soaps such as aluminum salt, calcium salt, magnesium salt, zinc salt, potassium and sodium salt, and nitrogen-containing derivatives such as amide; liquid paraffin (mineral oil), heavy Hydrocarbons such as quality liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin; candelilla wax, carnauba wax, rice wax, Waxes such as wood wax, honey wax, montan wax, ozokelite, selecin, paraffin wax, microcrystallin wax, petrolatum, Fishertropsh wax, polyethylene wax, ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, saflower oil , Olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, Plants such as rapeseed oil, sunflower oil, wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc. Oils and fats; animal fats and oils such as beef fat, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as whale wax, lanolin, orange raffy oil Liquid lanolin, reduced lanolin, adsorption purified lanolin, acetate lanolin, acetate liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, lanolin such as acetic acid (cetyl lanolin) ester Classes; sphingolin lipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, phospholipids such as lysolecithin; , Phosphorlipid derivatives such as partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, lacic acid; sapogenins; saponin Kind: Cholesteryl acetate, Cholesteryl nonanoate, Cholesteryl stearate, Cholesteryl isostearate, Cholesteryl oleate, Di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyl) Dodecyl), di-lauroyl-L-glutamate (phytosteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), acylsarcosine alkyl esters such as N-lauroylsarcosin isopropyl, 12-hydroxy Cholesteryl stearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl, etc. Esters; lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl pariminate, octyldodecyl palmitate, cetyl octanate, Hexyldecyl octanoate, isotridesyl isononanoate, isononyl isononanoate, octyl isononanoate, isotoridel isononanoate, ne Isodecyl opentaate, isotridecyl neopentate, isostearyl neopentate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinic acid, dicapryyl carbonate, hexyldodecyl dimethyloctanoate, octyldodecyl ercapate. , Isostearic acid hardened castor oil, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate , Methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate and other monoalcoholic carboxylic acid esters; cetyl lactate, Oxyate esters such as monoisostearic acid hydrogenated castor oil, γ-ercalactone, diisostearyl malate; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (capric acid / capric acid) ) Glyceryl, tri (capric acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eikosanate behate, trimethylol propanate trioctanoate, Trimethylol propane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenation Rozine pentaerythrityl, ditrimethylol propane triethylhexanoate, (isostearic acid / sebacic acid) ditrimethylol propane, pentaerythricyl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, tetraisostearia Polyglyceryl acid, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinorei) Acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopenate, 2,4-diethyl-dineopenate Polyhydric alcohol fatty acid esters such as 1,5-pentanediol; Alkyl ethers such as dicapryryl ether; Diisopropyl dimerginolate, diisostearyl dimerginolate, di (isostearyl / phytosteryl) dimergilinolate, Dimer dilinoleic acid (phytosteryl / behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearate dimer dinorail, dimer dilinoleyl hydrogenated rosin Derivatives of dimer acid or dimerdiol such as condensate, dimer dilinoleic acid hardened castor oil, hydroxyalkyl dimer dilinoleyl ether; palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), laurin Acid monoethanolamide (lauramide MEA), laurate diethanolamide (lauramide DEA), laurate monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (palmitamide MEA), palmitate diethanolamide (palmitamide DEA), palm oil fatty acid Fatty acid alkanolamides such as methylethanolamide (cocamidomethylMEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, Diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyldimethicone and amodimethicone, cation-modified silicones, dimethicone polyols, etc. Polyether-modified silicone, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphate-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, al Kill ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cationic-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amidoalkyl-modified silicone, aminoglycol-modified silicone , Aminophenyl-modified silicones, silicones such as polysiloxane / oxyalkylene copolymers; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferable.

Examples of the moisturizing agent / feel improving agent include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, and the like. Polypolymers such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and its polymers; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, polyglyceryl-10 tetradecanedioate, cyclohexanedicarboxylic acid Water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose, treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Heparin and derivatives, saccharides such as pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer and derivatives thereof; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , Caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fluctanes such as inulin, levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and salts thereof. Urea; Salts such as 2-pyrrolidone-5-carboxylic acid and sodium thereof; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threoni , Glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosin, creatin, etc. Amino acids and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide, keratin-degrading peptide, hydrolyzed keratin, conchiolin-degrading peptide, Protein peptides such as hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide and their derivatives; Aylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, submandibular gland mutin, hypotaurine, sesame lignan glycoside, glutathione, Albumin, emulsion; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hechima water, chamomile extract, kanzo extract, comfrey extract, silk extract, isayoibara extract, eucalyptus extract, eucalyptus extract , Animal / plant extracts such as melilot extract, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxy ceramides, pseudo-ceramides, sphingoglycolipids, ceramides and ceramides such as sugar ceramide-containing extracts. It is mentioned as a preferable one.

As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants and the like are preferable. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulphates such as sodium lauryl sulphate, triethanolamine lauryl sulphate and ammonium lauryl sulphate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulphate and triethanolamine laures sulphate; sodium cocoyl methyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristyl methyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sarcosin, lauroyl sarcosin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. , Acylamino acid salts such as lysine Na dilauroyl glutamate; Polyoxyethylene alkyl ether acetates such as sodium laureth acetate; Sulfonic acid ester salts such as sodium lauroyl monoethanolamide succinate; Polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzene polyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate; Alkyl sulfosuccinates such as lauryl disodium acid, sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as laures disodium sulfosuccinate, monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkyl benzene sulfonates such as sodium benzene sulfonate, triethanolamine tetradecyl benzene sulfonic acid; alkyl naphthalene sulfonate; alkane sulfonate; α-sulfo fatty acid methyl ester salt; acyl acetylionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetate; Alkyl phosphate ester salts such as sodium laures phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooleth phosphate; Alkyl phosphate ester salts such as potassium lauryl phosphate; Sodium caseinate; Alkyl aryl ether Phosphate; fatty acid amide ether phosphate; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; Anionic surfactants, etc .; Among nonionic surfactants, laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxy) Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as ethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldodeces (polyoxyethylene octyldodecyl ether); polyoxyethylene alkylphenyl ether; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, poly Oxyethylene hydrogenated castor oil and castor oil derivatives such as maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxy Polyethylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Polyoxyethylene / polyoxypropylene alkyl ether; polyoxyethylene / polyoxypropylene glycol; (poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Celyl, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocotton oil fatty acid glycerin, glycerin monoercaate, glycerin sesquioleate, α, α'-glycerin oleate, monostearic acid Glycerin fatty acid partial esters such as acid glycerin malic acid; polyglyceryl-2, 3, 4, 4, 6, 8, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate- 2. Polyglyceryl decastearate-10, polyglyceryl isostearate-2, 3, 4, 4, 5, 6, 8, 10, 10, polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, 10 , Polyglyceryl-2 triisostearate, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 oleate, 3, 3, 5, 5, 6, 8, Polyglyceryl dioleate- 6. Polyglycerin fatty acid ester such as polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol moiety Fatite ester; sorbitol partial fatty acid ester; martitol partial fatty acid ester; martitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan Solbitan fatty acid esters such as trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; partial esters of sugar derivatives such as sucrose fatty acid ester, methylglucoside fatty acid ester, trehalose undecylate; Alkyl glucosides such as glucosides; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di Ole Polyoxyethylene fatty acid mono and diesters such as alcohol; polyoxyethylene / propylene glycol fatty acid ester; polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, etc. Polyoxyethylene glycerin fatty acid esters such as monooleate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate. Polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate; polyoxyethylene methylglucoside fatty acid esters; poly Oxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol honey; alkyl glyceryl ethers such as isostearyl glyceryl ethers, chimyl alcohols, ceracyl alcohols and batyl alcohols; polyhydric alcohol alkyl ethers; poly Oxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; coconut oil fatty acids monoethanolamide (cocamide MEA), coconut oil Fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolami Alcohol alkanolamides such as de (partamide DEA) and coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkylethoxydimethylamine Oxide; polyoxyethylene alkyl mercaptan; polyether such as dimethicone copolyol Ammonium-based nonionic surfactants such as ammonium-modified silicones, polysiloxane / oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; Alkyltrimethylammonium chlorides such as cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; Fatty acid amidamines such as stearamide ethyldiethylamine and salts thereof; alkyletheramines such as stearoxypropyldimethylamine and salts thereof or quaternary salts; long-chain ethylsulfate branched fatty acids (12-31) aminopropylethyldimethylammonium, lanolin ethylsulfate Fatty acid amide type quaternary ammonium salt such as fatty acid aminopropyl ethyl dimethyl ammonium; polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol Ammonium salt; benzalconium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; polyamine fatty acid derivative; aminopropyldimethicone and amodimethicone Silicone-based cationic surfactants such as modified silicones, cationically modified silicones, cationically modified and polyether-modified silicones, amino-modified and polyether-modified silicones; among amphoteric surfactants, lauryl betaine (lauryl dimethylaminoacetic acid betaine) and the like. N-alkyl-N, N-dimethyl amino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoammonium acetate and sodium lauroammonium; alkyl Alkyl sulfobetaine such as dimethyl taurine; sulfuric acid betaine such as alkyl dimethylaminoethanol sulfate ester; phosphoric acid betaine such as alkyl dimethyl amino ethanol phosphate; phosphatidylcholine, phosphatidylethanola Sphingomyelin lipids such as min, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as lecithin hydroxide; Silicone-based amphoteric surfactants and the like; As polymer surfactants, polyvinyl alcohol, sodium alginate, starch derivatives, tragant gum, acrylate / alkyl methacrylic acid copolymers; various silicone-based surfactants are preferable.

Examples of the polymer / thickener / gelling agent include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as sodium thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethyl Ammonium sulfate cellulose, crystalline cellulose, cellulose powder and other cellulose and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenyl succinate, etc. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene Polyoxypropylene copolymer; amphoteric methacrylate copolymer such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrelites / stearyl acrylate / ethylamine methacrylate) copolymer; (dimethicone / vinyldimethicone) cloth Polymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylic acid, carboxyvinyl polymer, salt such as polyacrylic acid and sodium salt thereof, acrylic acid / methacrylic acid ester copolymer; acrylate / alkyl methacrylic acid Polymers: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39. -Diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-cationized metaacrylic acid ester copolymer, acrylic acid-cationized metaacrylic acid amide copolymer, polyquaterium-47 and other acrylic acid-methyl acrylate-chloride Methacylamide propyltrimethylammonium copolymer, choline chloride methacrylate polymer; cationized oligosaccharide, cationized dextran, cationized polysaccharide such as guarhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polyquaternium-51, etc. 2-Polymer of methacryloyloxyethyl phosphorylcholine, polymer with butyl methacrylate copolymer, etc .; acrylic resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and Its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin myristinate; silicic anhydride, fuming silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, Bentonite, hectrite, organically modified clay minerals, sucrose fatty acid esters, fructo-oligosaccharide fatty acid esters are preferred.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl bisulfite; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sulfites such as sodium bisulfite; hydrogen sulfites such as sodium bisulfite; thiosulfates such as sodium bisulfite; metahydrosulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. Is listed as. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable. Examples of the antioxidant include ascorbic acid phosphate salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt; ascorbic acid monostearic acid ester, ascorbic acid monopalmitic acid ester, and ascorbic acid di. Ascorbic acid fatty acid esters such as palmitate, ascorbic acid tetraisopalmitic acid ester; ascorbic acid such as 3-O-ethylascorbic acid, 2-O-ethylascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, hexyl glyceryl ascorbic acid Acid ethers; ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate; retinol, retinol acetate, retinol palmitate, hydrogenated retinol, etc. Vitamin A; Vitamin E such as tocopherol, tocopherol acetate, tocotrienol; Carotenoids such as carotene, lycopene, ascorbic acid, lutein; Polyphenols; coenzyme Q10, lipoic acid, lactoferrin, sesamine, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, platinum nanocolloid and the like are preferable.

Examples of the whitening agent include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid phosphate ester salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt; ascorbic acid. Ascorbic acid fatty acid esters such as monostearic acid ester, ascorbic acid monopalmitic acid ester, ascorbic acid dipalmitic acid ester, ascorbic acid tetraisopalmitic acid ester; 3-O-ethylascorbic acid, 2-O-ethylascorbic acid, Ascorbic acid ethers such as cetyl ascorbic acid, glyceryl ascorbic acid, hexylglyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate Derivatives: Tranexamic acid derivatives such as tranexamic acid, cetyl tranexamic acid, tranexamic acid amide; , Butyl resorcinol, oil-soluble chamomile extract, oil-soluble kanzo extract, Nishikawayanagi extract, Yukinoshita extract and other plant extracts are preferred.

Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmitate, etc. Flavin adenine dinucleotide, cyanocobalamine, folic acid, nicotinic acids such as nicotinic acid amide and benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and salts such as sodium thereof; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate ester salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, tetra ascorbic acid Ascorbic acid fatty acid ester such as isoparmic acid ester, ascorbic stearate, ascorbic palmitate, ascorbic dipalmitate, alkyl ether ascorbic acid such as ethyl ether ascorbic acid, ascorbic acid glucoside such as -2-glucoside ascorbic acid and its fatty acid ester. , Ascorbic acid derivatives such as tocopheryl ascorbic acid; tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol derivatives such as tocopherol phosphate, and other vitamin derivatives, tocotrienol, and other various vitamin derivatives are preferable. Is listed as.

Plant / animal / microbial extracts include iris extract, acitaba extract, asunaro extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract. , Inchikou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otanenjinjin extract, Otogirisou extract, Odorikousou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, karukade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, cutinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, crematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, quail extract, gentiana extract, gennoshouko extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, Fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sun Show extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract , Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract , Soybean extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Paris etalia extract, Hikiokoshi extract, Bisaborol, Hinoki extract, Bifizus bacterium extract , Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie Extract, Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea Extracts such as extract, leishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, and crackle extract are preferable.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoate ethyl. Anthroic acid-based UV absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl esters, N, N-dimethylparaaminobenzoic acid ethyl esters; Anthranilic acid-based UV absorbers such as homomentyl-N-acetylanthranilate; salicylic acid And salicylic acid-based ultraviolet absorbers such as sodium salts, amilsalicylate, menthyl salicylate, homomentyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl. -2,5-Diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cyraxic acid-based UV absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzophenones such as −phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone UV absorbers; 3- (4'-methylbenziliden) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5-( 3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidine propionic acid Hydantin derivatives such as 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalylidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferred.

Examples of antibacterial and antiseptic agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol. 1,2-Alcandiols such as; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexyl glycerin); salicylic acid; lanolin fatty acids and salts thereof; sodium benzoate; methylchloroisothiazolinone, methylisothiazolinone, etc. Isothiazolinone derivatives; imidazolinium urea; dehydroacetic acid and salts thereof; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zincpyrythion, benzalkonium chloride, benzethonium chloride, sorbin Acids, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokithiol; other phenols such as phenol, isopropylphenol, cresol, timole, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial Phenoxyethanol; 1,2-pentanediol, It is more preferable to use 1,2-alkanediols such as 1,2-hexanediol and 1,2-octanediol; and alkylglyceryl ethers such as 2-ethylhexyl glyceryl ether.

Examples of the chelating agent include edetates (ethylenediamine tetraacetate) such as EDTA, EDTA2Na, EDTA3Na and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; ethidroic acid and the like. Phosphonic acid and salts such as sodium salts thereof; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred.

pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol. Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as: ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, glycol ether esters such as propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl Propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, carbon dioxide and the like are preferred.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine, glycolic acid and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid, caffeine and the like. Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and a salt thereof, deoxyribonucleic acid and a salt thereof, and disodium adenosine triphosphate.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednison, diphedramine hydrochloride, Chlorpheniramine maleate; plant extracts such as peach leaf extract and holly leaf extract are preferred. As hair growth agents, blood circulation promoters and stimulants, plant extracts and tinctures such as senburi extract, capsicum tincture, ginger tincture, ginger tincture, and cantalis tincture; , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycosyl, minoxidil are preferable. Is listed as. As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable.

Examples of the anti-wrinkle / anti-aging agent include ascorbic acid phosphate salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt; ascorbic acid monostearic acid ester, ascorbic acid monopalmitic acid ester, and the like. Ascorbic acid fatty acid esters such as ascorbic acid dipalmitic acid ester, ascorbic acid tetraisopalmitic acid ester; 3-O-ethylascorbic acid, 2-O-ethylascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, hexylglyceryl ascorbic acid Ascorbic acid ethers such as; ascorbic acid glucoside such as ascorbic acid-2-glucoside and fatty acid esters thereof; ascorbic acid derivatives such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate; retinol, retinol acetate, retinol palmitate, hydrogen Vitamin A such as added retinol; nicotinic acid amide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanin, pantothenic acid, pantenol, soybean saponin, levelastol, isoflavone, coenzyme Q10, chondroitin sulfate, Acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolyzate, adenosine 5'monophosphate, phosphatidylinositol, isopropyloxopropylaminocarbonylpyrrolidincarbonylmethylpropylaminocarbonylbenzoylaminoacetate Na trifluoride , Tranexamic acid and derivatives thereof and the like are mentioned as preferable ones.

Examples of the stimulant alleviator include mannosyl erythritol lipid, diethylene glycol oligomer ester of dimer dilinoleic acid, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, and phenylethyl glucoside. Lauryl glucoside, ferulic acid glucoside, salicin, sedrol, polyethylene glycol, polypropylene glycol and the like are preferable. Preferable examples of the cooling agent include menthol, camphor, menthol lactate, monomentyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, peppermint oil and derivatives thereof. Examples of warming agents include vanillin and its derivatives, nicotinic acid derivatives such as nonanoic acid vanillylamide, shogaol, gingerol, togarashi tincture, togarashi extract, benzyl nicotinate, methyl nicotinate, phenyl nicotinate, tocopherol nicotinate, capsaicin, and the Netherlands. Preferable examples include ginger extract, sansho extract, shogaol extract, and cantari extract.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, cay. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, dark blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , Fine and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic or Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface treatment powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates and magnesium phosphates are preferred.

Dyes / colorants / dyes / pigments include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, and blue 204. , Blue 205, Blue 403, Blue 404, Green 3, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, Red 105-1, Red 106, Red 2, Red 3, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207 , Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503 , Red 504, Red 505, Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow Legal dyes such as 405, Yellow 406, Yellow 407, Yellow 5; Other acidic dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow such as yellow iron oxide and yellow clay System pigments: Inorganic black pigments such as black iron oxide and low-order titanium oxide; Inorganic substances such as mango violet and cobalt violet Purple pigments; Inorganic green pigments such as chromium oxide, chromium hydroxide, cobalt titanate; Inorganic blue pigments such as ultramarine and dark blue; Titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored oxidation Pearl pigments such as titanium coated mica, bismuth oxychloride, fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthocyanidins such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantin, calcon, calsamine, Naftquinones such as quercetin, crosin, chlorophyll, curcumin, cochineal, and sikonin, bixins, flavones, betacyanidins, henna, hemoglobin, lycopene, riboflavin, natural pigments and dyes such as rutin; p-phenylenediamine, toluene-2,5 Oxidizing dyes such as -diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, etc. and salts thereof. Body and couplers; auto-oxidizing dyes such as indolin; dihydroxyacetones are preferred.

As fragrances, acetylsedrene, amylcinnamaldehyde, allylamylglycolate, β-ionone, isoe super, isobutylquinolin, iris oil, iron, indol, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galaxolid, Carbachlor, L-Carbon, Kamfer, Cannon, Carrot Seed Oil, Clove Oil, Methyl Silica, Geraniol, Geranyl nitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarbinate acetate, Styralyl acetate, Cedril acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linaryl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santa roll, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux Reginoid, Cedarwood Oil, Cedren, Sedrol, Celori Seed Oil, Thyme Oil, Damascon, Damasenon, Timor, Tuberose Absolute, Decanal, Decalactone, Terpineol, γ-Terpinen, Triplar, Nerol, Nonanar, 2,6-Nonadienor, Nonalactone, Pachori Alcohol, vanilla absolute, vanillin, basil oil, patcholi oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil , Lavender oil, D-limonen, linalol, liraal, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances such as various essential oils and natural Fragrances and various blended fragrances are preferred.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable.

In addition to these, cosmetic raw material standards, compounding ingredient standards by cosmetic type, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), pharmaceutical non-pharmaceutical raw material standards, Japanese Pharmacy, pharmaceutical additives Ingredients described in standards, food additive official documents, etc., and Japanese and foreign patent gazettes and patent publication gazettes (including publication gazettes and republishing) whose international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the described ingredients, in known combinations, blending ratios, and blending amounts.

Examples of the type of cosmetics of the present invention include hair cosmetics, skin cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics and the like. The cosmetic of the present invention can be produced according to a usual method.

Explaining the types of cosmetics of the present invention in more detail, hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, perm shampoos, hair coloring shampoos, rinse-integrated shampoos and other shampoos; rinses, conditioners, etc. Hair care agents such as treatments, hair packs, hair mists, hair oils; hair styling products such as hair foams, hair mousses, hair sprays, hair waxes, hair gels, hair creams, water greases, set lotions, pomades, tics; color lotions, hair color treatments, Hair dyes such as hair manicure, oxidative hair dye; hair tonic, hair liquid, hair blow, split hair coat, permanent wave agent, straight perm agent, hair bleach, hair color pretreatment, hair color after treatment, perm pretreatment , Perm after treatment, hair styling products are preferred.

As skin cosmetics, softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, liposome lotion and other lotions; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin Emulsion such as moisturizer, moisturizer emulsion, massage lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutrition cream, nourishing cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, Makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc.; moisturizing gel, whitening gel, all-in-one gel, etc.; moisturizing essence , Beauty liquids such as whitening essence, moisturizing serum, whitening serum; sunscreens such as sun protect, sun protector, UV care milk, sun screen; peel-off pack, powder pack, washing pack, oil pack, cleansing mask, etc. Kind; Makeup remover such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil; paste face wash foam, gel face wash foam, foam face wash foam, face wash powder, cosmetic soap, clear soap, medicated soap, liquid soap , Cleansers such as shaving soap; are preferred.

As makeup cosmetics, lipstick, lip gloss, foundation, blusher, white powder / dusting powder, concealer, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment are preferable.

Preferable aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, cologne, perfume paste, fragrance powder, perfume soap, body lotion, and bath oil.

Body cosmetics include body cleaners such as body shampoo, deodorant lotions, deodorant powders, deodorant sprays, deodorant cosmetics such as deodorant sticks, depigmenting agents, depilatory / depilatory agents, bathing agents, insect repellent sprays, etc. Repellers are preferred.

As the type of the skin external preparation of the present invention, ointments, lotions, creams or gel-like external skin agents, patches, liniment agents, liquid coating agents and the like are preferable. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

As the dosage form of the cosmetic or skin external preparation of the present invention, emulsification of oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type and the like. Type cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste-like cosmetics, stick-like cosmetics, volatile oil-type cosmetics, powder-like cosmetics, jelly-like cosmetics, gel-like cosmetics, paste-like Pharmaceutical types such as cosmetics, emulsified polymer type cosmetics, sheet-like cosmetics, mist-like cosmetics, and spray-type cosmetics are preferable.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

<Evaluation of bacterial growth or growth suppression>
Staphylococcus epidermidis that had been pre-cultured in advance ^{was suspended in physiological saline to a concentration of 1 × 10 8} cfu / mL to prepare a bacterial solution. Next, the bacterial solution was added to the SCD liquid medium to which the lanolin fatty acid shown in Table 1 was added so as to be 200 μg / mL so as to be 1 × 10 ⁷ cfu / mL, and the cells were aerobically cultured at 37 ° C. for 18 hours. .. The liquid medium after culturing was diluted with LP diluted solution to an appropriate cell concentration, added to SCD agar medium, and then aerobically cultured at 37 ° C. for 18 hours. As a control, the same culture was carried out in a medium to which no lanolin fatty acid was added. The evaluation of bacterial growth or growth suppression was performed by visually confirming the number of colonies on the agar medium after culturing. The evaluation criteria are as follows, and the results are shown in Table 1. A similar test was performed on Staphylococcus aureus, and the results are shown in Table 1.

Evaluation criteria ++: Increased number of colonies compared to control ++: Slightly increased number of colonies compared to control ±: No change in number of colonies compared to control −: Slightly increased number of colonies compared to control Decreased −−: Decreased number of colonies compared to control

From the results in Table 1, it was confirmed that the lanolin fatty acid or a salt thereof has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus.

The prescription of the cosmetic containing the skin flora balance improving agent of the present invention is shown below.

Example 1 Toner
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.5
BG 4.0
Glycerin 2.0
Innocitol 0.5
Glycyrrhizinate 2K 0.01
Ethanol 3.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 0.1
Polysorbate-80 1.0
Decyl glucoside 0.5
Citric acid 0.1
Amount of sodium citrate pH 4.5 Ca carbonate 0.2
Edetonic acid 3Na 0.1
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 Part B Xanthan gum 0.05
BG 3.0
Purified water 20.0
Part C 3-O-ethylascorbic acid (Nippon Fine Chemical Co., Ltd.) 0.1
Purified water 5.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A was heated to about 80 ° C. and dissolved uniformly. Part B was slowly added to part A with stirring, cooled to 40 ° C., and then part C was added to obtain a uniform liquid.

Example 2 Toner component compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.3
Diglycerin 3.0
Hydrolyzed hyaluronic acid 0.01
Arginine 0.05
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 0.5
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 0.2
PEG-400 1.5
PEG-32 2.0
PPG-6 decyl tetradeceth-30 0.2
PEG-60 hydrogenated castor oil 0.2
PEG-30 phytosterol 0.1
Cocoyl hydrolyzed collagen K 0.5
Betaine 0.5
Pullulan 0.5
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Hydroxyethyl cellulose 0.03
Carbomer 0.05
Glyceryl caprate 0.5
Amount of purified water totaling 100 Part B Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Citric acid 0.01
Na citrate 0.05
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was heated to about 80 ° C. and mixed uniformly. Part B was added to obtain a uniform liquid.

Example 3 Moisturizing lotion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.3
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 0.5
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 0.1
Diglycerin 2.0
Polyglyceryl laurate-10 0.3
Polyglyceryl Decaoleate-10 0.6
Polyglyceryl diisostearate-2 0.3
Betaine 1.0
Pyridoxine palmitate 0.1
Part B Glycyrrhizinate 2K 0.1
PCA Zinc 0.3
Alginate Ca 0.1
Phenoxyethanol 0.4
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were heated to obtain a uniform liquid. Part B was gradually added while stirring part A, and the mixture was cooled.

Example 4 Gel lotion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Isostearic acid 0.3
PEG-30 phytosterol 0.1
Part B Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) Arginine salt 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.4
1,2-Hexanediol 0.1
Polymethacryloyl lysine 0.05
Polylysine 0.2
Ornithine 0.2
Allantoin 0.1
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Pantothenate Ca 0.2
Hyaluronic acid Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Amount of purified water totaling 100 Part C Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.1
(Dimethyltaurine ammonium acrylate / vinylpyrrolidone) copolymer
0.05
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer
0.05
Purified water 30.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part B was mixed, stirred well, made uniform, and then heated to about 70 ° C. Part B was added to part A, stirred at about 70 ° C. using a homomixer, cooled to about 40 ° C., and part C was added.

Example 5 Whitening emulsion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-LG3 (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-DP (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Isopropyl palmitate (Nippon Fine Chemical Co., Ltd.) 5.0
Cetanol 1.2
Phenyltrimethicone 3.0
Isopropyl myristate (Nippon Fine Chemical Co., Ltd.) 3.0
Mineral oil 2.0
Hydrogenated polyisobutene 1.0
Part B Stearoxy hydroxypropyl Methyl Cellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Pentylene glycol 3.0
Glycerin 8.0
Part D 3-O-ethylascorbic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Salicylic acid 0.5
Purified water 5.0
Part E Phytic acid 0.5
Guanidine 1.0
Lysine 0.2
Citric acid 0.1
Amount of sodium citrate pH 4.5 Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− −−−−−
(Preparation method)
Parts A and E were each heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dispersed uniformly. After adding part A while stirring part C with a homodisper, part E was added while stirring. Parts D and B were added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 6 Whitening emulsion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 5.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 5.0
Lauroyl lysine 0.2
Cetanol 1.2
Phenyltrimethicone 3.0
Ethylparaben 0.1
Myristyl Alcohol 2.0
Oleyl alcohol 1.0
Part B Stearoxy hydroxypropyl Methyl Cellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Pentylene glycol 2.0
1,2-Hexanediol 1.0
BG 5.0
Glycerin 8.0
Part D Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Gravlysin 0.1
Purified water 5.0
Part E Na Sulfite 0.05
Phytic acid 0.5
Arginine 1.0
Lysine 0.2
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and E were each heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dispersed uniformly. After adding part A while stirring part C with a homodisper, part E was added while stirring. Parts D and B were added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 7 Milky lotion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical Co., Ltd.) 1.0
Hydrogenated lysophospholipid (Nippon Fine Chemical Co., Ltd.) 0.1
Part B Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 1.0
Trioctanoin (Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Setostearyl alcohol 1.0
Arachidyl alcohol 0.1
Jojoba Alcohol 3.0
Kimil alcohol 0.3
Ceraquil Alcohol 0.1
Hexildecanol 0.5
Part C (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer
0.2
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.03
Carbomer 0.1
Purified water 20.0
Part D Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
Polyquaternium-51 1.0
Ascorbyl Glucoside 1.0
Potassium hydroxide 0.3
Phenoxyethanol 0.4
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 8 Skin care cream compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.3
Squalene 5.0
Stearic acid 1.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 1.0
Macadamia nut oil 3.0
Hydrogenated jojoba oil 2.0
Vaseline 2.0
Stearyl glycyrrhetinate 0.05
Olive oil fatty acid cetearyl 1.0
Olive oil fatty acid sorbitan 0.8
Lanolin fatty acid arginine salt 1.5
Polyglyceryl oleate-10 1.0
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(Acryloyl dimethyl taurine ammonium /
Behenes Methacrylic Acid-25) Cross Polymer 0.2
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 10.0
Hydrolyzed polyγ-glutamic acid K 0.1
Polyglutamic acid Na 0.1
Oligopeptide-24 0.05
Part C Inulin-SC (Nippon Fine Chemical Co., Ltd.) 1.0
Glycerin 9.0
Propane diol 10.0
PEG-8 5.0
Nicotinamide 2.0
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 9 Skin care cream compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Glycerin 12.0
BG 6.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 2.5
Part B Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.2
Olive oil 1.5
Shea butter 1.0
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 5.0
Sucrose stearate 0.8
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ceramide 2 0.01
Ceramide 3 0.01
Ceramide 5 0.01
Ceramide 6 0.01
Retinol palmitate 0.01
Ascorbyl Tetrahexyl Decanoate 7.0
Lauroyl sarcosine isopropyl 2.0
Hydrogenated cocoglyceryl 3.0
Cetanol 2.5
Sorbitan stearate 0.8
Part C xanthan gum 0.05
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
Sodium metabisulfite 0.03
Aluminum Sulfate / Potassium 0.05
Nicotinamide 1.0
Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Part D Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Propanediol 3.0
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 10 Skin care cream compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 2.0
Squalene 8.0
Behenyl alcohol 1.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 1.0
γ-Oryzanol 0.2
Macadamia nut oil 3.0
Hydrogenated jojoba alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl oleate-10 1.0
Polyglyceryl laurate-10 0.5
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
Hydroxyethyl Acrylate / Acryloyl Dimethyltaurine Na) Copolymer 0.05
(Acryloyldimethyltaurine ammonium / Behenes methacrylic acid-25)
Cross polymer 0.05
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 10.0
Polyglutamic acid Na 0.1
Oligopeptide-24 0.05
Part C Neosolue-Aqua (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Mannosil Erythritol Lipid 0.2
Diglycerin 5.0
Propanediol 3.0
PEG-8 2.0
Sodium metabisulfite 0.03
Methylparaben 0.1
Phenoxyethanol 0.3
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 11 Cleansing cream compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 5.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-S (Nippon Fine Chemical Co., Ltd.) 2.0
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 2.0
Diisostearyl malate 6.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 2.0
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 2.0
Mineral oil 23.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 10.0
PEG-25 hydrogenated castor oil 3.0
PEG-20 glyceryl triisostearate 4.0
PEG-12 isostearate 3.0
Sorbitan sesquioleate 1.5
Polyoxyethylene sorbitan oleate 0.3
Polyglyceryl stearate-6 0.5
Glyceryl stearate 1.0
Microcrystalline wax 2.0
Tocopherol 0.05
Propylparaben 0.05
Part B Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Diglycerin 3.0
DPG 5.0
Edetonic acid 3Na 0.02
Phenoxyethanol 0.5
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was weighed and heated to about 80 ° C. to dissolve. Weigh part B and heat to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 12 Facial cleansing foam compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 2.0
Stearic acid K 10.0
Palmitic acid K 10.0
Myristic acid K 10.0
Lauric acid K 4.0
Titanium oxide 1.0
Talc 0.5
Lauroyl sarcosine isopropyl 0.8
PEG1500 10.0
Glycerin 15.0
Glyceryl monostearate 1.0
POE (20) Sorbitan Monostearate 2.0
Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Hydroxypropyl Methyl Cellulose 0.05
Tuberose polysaccharide 0.05
Cationized guar gum 0.05
Glycyrrhizinate 2K 0.05
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Glyceryl caprylate 0.5
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was weighed and heated to about 80 ° C. to dissolve. Weigh part B and heat to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 13 Hand cream compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 8.0
Ercolano CLE-S (Nippon Fine Chemical Co., Ltd.) 5.0
LUSPLAN DD-DA7 (Nippon Fine Chemical Co., Ltd.) 0.5
Squalene 8.0
Macadamia nut oil 0.5
Rosehip oil 1.0
Meadowfoam oil 1.0
Vaseline 15.0
Microcrystalline wax 2.0
Glyceryl stearate 2.0
Cetanol 2.0
Cetyl phosphate 1.0
Lanolin alcohol 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Glycerin 8.0
Propanediol 5.0
Phenoxyethanol 0.3
Ethylhexyl glycerin 0.5
Na hydroxide 0.5
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part B was heated to about 70 ° C. and dissolved. Part A was placed in another container and heated to about 80 ° C. to dissolve it. Part A was added to part B with stirring with a homomixer and emulsified. After emulsification, it was cooled to about 40 ° C.

Example 14 Facial cleansing foam compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Cocoyl Glycine K 5.0
Sodium lauroyl glutamate 4.0
Cocoyl methyl taurine Na 2.0
Decyl glucoside 3.0
Cocamidopropyl Betaine 2.0
Betaine 1.0
Stearic acid K 1.0
Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) Arginine Salt 3.0
Lauroyl sarcosine isopropyl 0.8
PPG-Arginine 5.0
Glycerin 15.0
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 0.2
Glyceryl monostearate 1.0
Part B Inulin-SC (Nippon Fine Chemical Co., Ltd.) 1.0
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Phytopresome MEL 1.0
Hydroxypropyl Methyl Cellulose 0.2
Ercolano CA-NH (Nippon Fine Chemical Co., Ltd.) 0.1
Phenoxyethanol 0.5
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 15 Lipstick compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 4.0
Hydrogenated polyisobutene 6.0
LUSPLAN DD-DA7 (Nippon Fine Chemical Co., Ltd.) 3.0
Polybutene 8.0
Polyethylene 5.0
Ethyl cellulose 0.2
Synthetic wax 1.2
Shea butter 3.0
Iron oxide 2.3
Mica 1.5
Titanium oxide 2.5
Red 202 1.5
Cetyl ethylcaproate (Nippon Fine Chemical Co., Ltd.) 5.0
Sorbitan sesquioleate 1.0
Tocopherol 0.05
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
All components were heated to about 80 ° C., mixed uniformly and then cooled to room temperature.

Example 16 Foundation compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 1.0
Isododecane 10.0
Tri (capric acid / caprylic acid) glyceryl (Nippon Fine Chemical Co., Ltd.) 4.0
Ethylhexyl methoxycinnamate 3.0
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-LG4 (Nippon Fine Chemical Co., Ltd.) 1.0
Vaseline 1.0
Isotridecyl isononanoate 2.0
Ascorbyl tetrahexyl decanoate 0.1
Dextrin palmitate 0.3
Sorbitan isostearate 1.5
Ca 1.0 stearate
Tribehenin 0.5
(Butyl acrylate / glycol dimethacrylate) Crosspolymer,
Silica, (methyl methacrylate / glycol dimethacrylate) cross-polymer mixture
2.0
Boron Nitride 1.0
Polysorbate 20 2.0
PEG-60 hydrogenated castor oil 1.0
Gistear dimonium hectorite (20%) 2.5
Polypropylsilsesquioxanecyclopentasiloxane mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium oxide 10.0
Iron oxide 1.5
Part B DPG 4.0
Maltitol (75% solution) 1.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.4
Na chloride 1.0
BG 1.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Histidine 0.7
Ethanol 0.5
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 70 ° C., stirred well and dispersed uniformly. Part B was heated to about 70 ° C. to make it uniform, and then part B was added to part A, stirred and emulsified at about 70 ° C., and cooled to about 40 ° C.

Example 17 Sunscreen cosmetic compound compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
BG 10.0
Glycerin 9.0
Part B Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.5
Ethylhexyl methoxycinnamate 7.0
Diethylaminohydroxybenzoyl hexyl benzoate 7.0
Behenyl alcohol 4.0
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Part C Inulin-SC (Nippon Fine Chemical Co., Ltd.) 0.3
Amount of purified water totaling 100 Part D Xanthan gum 0.2
Hyaluronic acid Na 0.01
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was uniformly dispersed. Parts B and C were each heated and dissolved at about 70 ° C. After gradually adding the B part to the A part, the C part was gradually added and emulsified. The mixture was cooled with stirring, part D was added at 45 ° C., and the mixture was uniformly mixed.

Example 18 Shampoo compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.2
Isopropyl palmitate (Nippon Fine Chemical Co., Ltd.) 0.2
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Oleic acid 0.2
Part B Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
Cocoyl Glutamic Acid TEA (30%) 3.0
Lauryl hydroxysultaine (30%) 7.0
Lauric acid K 1.0
Glycol distearate 0.5
Stearoxypropyl dimethylamine 0.5
PPG-17 0.3
Neopentyl glycol diethylcaproate 0.4
Isodecyl glyceryl ether 0.4
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Stairless-6 0.2
Miconazole nitrate 0.75
Phenoxyethanol 0.3
Part C Sorbitol 1.6
Phenoxyethanol 0.4
EDTA-2Na 0.05
Phosphoric acid 0.03
Na benzoate 0.3
Amount of purified water totaling 100 Part D Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 6.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A and part B, which had been mixed in advance, were uniformly mixed at about 80 ° C. (part E). Part C, which was set aside, was heated to about 60 ° C. to make it uniform. Part C was gradually added to part E with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part D was added and mixed uniformly.

Example 19 Shampoo compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.2
Isopropyl palmitate (Nippon Fine Chemical Co., Ltd.) 0.2
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Oleic acid 0.2
Part B Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
Cocoyl Glutamic Acid TEA (30%) 3.0
Lauryl hydroxysultaine (30%) 7.0
Lauric acid K 1.0
Glycol distearate 0.5
Stearoxypropyl dimethylamine 0.5
PPG-17 0.3
Neopentyl glycol diethylcaproate 0.4
Isodecyl glyceryl ether 0.4
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Stairless-6 0.2
Miconazole nitrate 0.75
Phenoxyethanol 0.3
Part C Sorbitol 1.6
EDTA-2Na 0.05
Phosphoric acid 0.03
Na benzoate 0.5
Amount of purified water totaling 100 Part D Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 6.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A and part B, which had been mixed in advance, were uniformly mixed at about 80 ° C. (part E). Part C, which was set aside, was heated to about 60 ° C. to make it uniform. Part C was gradually added to part E with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part D was added and mixed uniformly.

Example 20 Shampoo compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.2
Isopropyl palmitate (Nippon Fine Chemical Co., Ltd.) 0.2
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Oleic acid 0.2
Part B Ammonium Laureth Sulfate 5.0
Sodium Laureth Sulfate (25%) 10.0
Cocoyl Glutamic Acid TEA (30%) 3.0
Lauryl hydroxysultaine (30%) 7.0
Lauric acid K 1.0
Glycol distearate 0.5
Stearoxypropyl dimethylamine 0.5
Dimethicone (10,000 cSt) 0.1
PEG-9 Dimethicone 0.1
PPG-17 0.3
Neopentyl glycol diethylcaproate 0.4
Isodecyl glyceryl ether 0.4
Cocamide MEA 1.0
Laureth-4 0.3
Laureth-16 0.2
Stairless-6 0.2
Miconazole nitrate 0.75
Phenoxyethanol 0.3
Part C Sorbitol 1.6
Methylparaben 0.2
EDTA-2Na 0.05
Phosphoric acid 0.03
Amount of purified water totaling 100 Part D Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 6.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A and part B, which had been mixed in advance, were uniformly mixed at about 80 ° C. (part E). Part C, which was set aside, was heated to about 60 ° C. to make it uniform. Part C was gradually added to part E with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part D was added and mixed uniformly.

Example 21 Shampoo component compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.5
Oleic acid 0.3
Lauroyl glutamate TEA 3.0
Cocoyl methylalanine Na 1.0
Hydrogenated palm oil fatty acid PEG-200 glyceryl 1.0
Coco Betaine (25%) 8.0
Glycerin 1.0
Polysorbate 20 0.5
Coconut oil fatty acid PEG-7 glyceryl 0.4
PPG-2 cocamide 0.3
PEG-40 hydrogenated castor oil 1.0
Tocopherol 0.03
Bisabolol 0.01
Part B Inulin-SC (Nippon Fine Chemical Co., Ltd.) 1.5
Na benzoate 0.4
Na chloride 0.5
3-O-ethylascorbic acid (Nippon Fine Chemical Co., Ltd.) 0.1
Amount of purified water totaling 100 Polyquaternium-10 0.3
Part C Phenoxyethanol 0.6
Phenethyl alcohol 0.2
Ethylhexyl glycerin 0.2
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Parts A and B, which had been mixed and dissolved in advance, were uniformly mixed at about 80 ° C. The mixture was gradually cooled with stirring, and part C was added at 60 ° C.

Example 22 Shampoo compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) Arginine salt 0.4
Diethyl sebacate (Nippon Fine Chemical Co., Ltd.) 0.5
Isostearyl alcohol 0.1
Cocoyl methyl taurine Na (30%) 8.0
Cocamidopropyl Betaine (30%) 5.0
Sodium Laureth Sulfate (25%) 6.0
Laureth-2 1.0
Solves Tetraoleate-60 3.5
Caprylyl glucoside 0.3
Polylysine 0.2
Cocamide DEA 3.0
PEG-20 hydrogenated castor oil 0.5
Neopentyl glycol diheptate 0.3
Ethyl oleate 0.3
Glyceryl caprate 0.5
Part B EDTA-2Na 0.05
Propane diol 0.5
Amount of purified water totaling 100 Part C NanoRepair-CMC5 (Nippon Fine Chemical Co., Ltd.) 8.0
Polyquaternium-10 0.1
Guar Hydroxypropyltrimonium Chloride 0.3
Trometamine 0.3
Arginine 0.5
Na hydroxide 0.1
Na chloride 0.3
Suizenji nori polysaccharide 0.1
Purified water 19.3
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was placed in a separate container and heated to dissolve it. Part B was gradually added to part A, mixed uniformly, and part C was added at about 60 ° C.

Example 23 Body shampoo compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.2
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.2
Cocamidopropyl Betaine 7.0
Cocoyl glycine K 5.0
Cocamide DEA 2.0
PEG-80 sorbitan laurate 3.0
Sodium lauroyl glutamate 4.0
DPG 2.5
Coconut oil alkyl glucoside 3.0
Glycerin 10.0
Cetanol 0.2
PEG-8 3.0
Pentylene glycol 2.0
Part B EDTA-2Na 0.05
Etidronic acid 3Na 0.10
Propinyl iodide butylcarbamate 0.01
Methylparaben 0.15
Amount of purified water totaling 100 Part C (styrene / alkyl acrylate) copolymer 0.2
Guar Hydroxypropyltrimonium Chloride 0.5
Phenoxyethanol 0.5
Purified water 8.8
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was placed in a separate container and heated to dissolve it. Part B was gradually added to part A, mixed uniformly, and part C was added at about 60 ° C.

Example 24 Cleansing balm compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Ethylhexyl palmitate A total amount of 100 Cetyl ethylhexanate (Nippon Fine Chemical Co., Ltd.) 10.0
Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-LG3 (Nippon Fine Chemical Co., Ltd.) 0.2
Plandoll-S (Nippon Fine Chemical Co., Ltd.) 0.5
PEG-20 glyceryl triisostearate 14.0
Alkyl (C12,14) Oxyhydroxypropyl Arginine HCl 0.3
Cocoyl arginine ethyl PCA 0.3
Polyethylene 5.5
Microcrystalline wax 2.0
Phenoxyethanol 0.5
Tocopherol 0.05
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
All components were weighed and mixed at about 90 ° C. with stirring until uniform.

Example 25 Cleansing oil compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 5.0
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 2.0
Cetyl ethylcaproate (Nippon Fine Chemical Co., Ltd.) 9.0
Mineral oil 14.0
Glycerin 16.0
BG 5.0
PEG-8 glyceryl isostearate 14.0
Coconut oil fatty acid PEG-7 glyceryl 14.0
Polyglyceryl diisostearate-2 1.5
EDTA-2Na 0.1
Citric acid 0.01
Na citrate 0.09
Amount of purified water totaling 100 -------------
(Preparation method)
All components were weighed and stirred and mixed until uniform at room temperature.

Example 26 Skull lotion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) Arginine salt 0.2
Glycerin 4.0
Pentylene glycol 2.0
Maltitol liquid 0.5
Glycyrrhetinic acid 0.05
PPG-5 Phytosterol 0.1
Betaine 0.2
Carrot extract 0.1
Swertia japonica extract 0.1
Menispermaceae root extract 0.003
Pyridoxine hydrochloride 0.05
Panthenol 0.1
PCA-Na 0.1
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
All components were weighed and stirred and mixed until uniform at room temperature.

Example 27 Skull lotion compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) Arginine salt 0.4
Glycerin 2.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
Nicotinamide 1.0
Dipotassium glycyrrhizinate 0.1
3-O-ethylascorbic acid (Nippon Fine Chemical Co., Ltd.) 0.3
Hyaluronic acid Na 0.01
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
Caprilyl proline 0.3
Raffinose 0.2
Arginine 0.5
Serine 0.1
Glycine 0.1
Amount of purified water totaling 100 Part B Ethanol 10.0
Methylparaben 0.1
Menthol 0.1
Mentoxipropanediol 0.1
Ethyl dicarboethoxypantothenate 0.2
Camphor 0.1
Carrot extract 1.0
Swertia japonica extract 1.0
Glycosyl trehalose 0.5
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
The components of parts A and B were measured and mixed uniformly. Part B was added to part A to make it uniform.

Example 28 Scalp treatment compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.8
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 2.0
Stearamidopropyl dimethylamine 0.8
Cetanol 3.0
Caprylyl glucoside (50%) 0.8
Part B Glycyrrhizinate 2K 0.1
Hydrolyzed keratin 0.1
Rosemary extract 0.1
Capillary wormwood extract 0.2
Pyridoxine hydrochloride 0.1
Part C Lactic acid 0.3
Glycerin 4.0
Phenoxyethanol 0.5
Amount of purified water totaling 100 -------------
(Preparation method)
Parts A and C were heated to about 80 ° C. and dissolved. Part C was added while stirring, and after mixing uniformly, the mixture was cooled to about 40 ° C. Then, part B was added and mixed uniformly.

Example 29 Scalp treatment compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Ercolano FA-NH (Nippon Fine Chemical Co., Ltd.) 0.4
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 4.0
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 1.0
Behentrimonium chloride (80%) 0.5
Behenyl alcohol 1.0
Stearyl alcohol 2.0
Glyceryl stearate 1.0
Ranorin Row 1.0
Dimethicone (10,000 cs) 1.0
Tridecyl neopentaneate 0.5
Myristyl isooctanoate 0.3
Neopentyl glycol diethylcaproate 0.3
Ethyl oleate 0.3
Glyceryl triisostearate 0.3
Trimethylolpropane triisostearate 0.3
Broccoli seed oil 0.3
Sphinganin 0.01
Glycerin 1.0
Part B Arginine 0.4
Na hydroxide 0.05
Phenoxyethanol 0.5
Amount of purified water totaling 100 Part C NanoRepair-CMC5 (Nippon Fine Chemical Co., Ltd.) 0.5
Polyquaternium-39 0.5
Part D Carrageenan 0.1
Hydroxypropyl chitosan 0.05
Hydroxypropyl Methyl Cellulose 0.1
Tuberose polysaccharide 0.1
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.005
Purified water 20.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Parts A and B were heated to about 80 ° C. and dissolved. Part D was dispersed to prepare a viscous liquid. Part A was added to part B with stirring, mixed uniformly, and then cooled to about 40 ° C. Next, parts C and D were added and mixed uniformly.

Example 30 Scalp treatment compounding amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
Part A Soft lanolin fatty acid (Nippon Fine Chemical Co., Ltd.) 0.4
Squalene 3.0
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 1.0
Ethanol 40.0
Stearyl glycyrrhetinate 0.02
PPG-3 Caprylyl Ether 0.3
Elcalactone DES (Nippon Fine Chemical Co., Ltd.) 1.5
PEG / PPG-20 / 20 Dimethicone 0.2
PEG-12 Dimethicone 0.4
Tocopherol 0.05
Hydrogenated retinol 0.1
Trishexyldecanoic acid pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexil 3-glyceryl ascorbic acid 0.3
Part B Triethanolamine 0.1
Trometamine 0.1
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.4
Carboxyvinyl polymer 0.05
(Acryloyl dimethyl taurine ammonium / VP) copolymer 0.05
(Acryloyldimethyltaurine ammonium / Behenez methacrylic acid-25) Crosspolymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Amount of purified water totaling 100 Part C 3-O-ethylascorbic acid (Nippon Fine Chemical Co., Ltd.) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyl trehalose 0.1
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−–
(Preparation method)
Part A was heated to about 50 ° C. and dissolved. Next, part B was uniformly dispersed to obtain a viscous liquid. Part A was added to part B with stirring and mixed uniformly. Then part C was added and mixed uniformly.

In the above formulation, the details of the ingredients described by the product names are as follows.
〇Ecolano CA-NH: Quotanium-33, BG
〇 Ecolano CLE-S: Lanorin fatty acid cholesteryl 〇 Inulin-SC: Inulin 〇LUS PLAN DD-DA7: Dimaryl linoleic acid 〇LUS PLAN SR-DM4: Dimage linoleyl dimalic acid, tri (caprylic acid / caprin) Acid) Glyceryl 〇NanoRepair-CMC5: Ceramide 1, Ceramide 2, Ceramide 3, Ceramide 5, Ceramide 6, Cholesterol, Quotanium-33-containing composition 〇Neosolue-DiSM: Diisostearyl malate 〇Neosolue-Aqualio: Cyclohexanedicarboxylic acid bis Ethoxydiglycol 〇 Neosolue-AquaS: (eicosandioic acid / tetradecanoic acid) polyglyceryl-10, glycerin 〇Plandol-H: dimer diphosphoric acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
〇Plandol-S: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
〇Plandol-G: Dimer dilinoleyl bis (behenyl / isostearyl / phytosteryl)
〇Plandol-DP: Bisdiglyceryl polyacyl adipate-2
〇Plandol-ISS: Phytosteryl isostearate 〇Plandol-SUN: Sunflower seed oil fatty acid phytosteryl 〇Plandol-MAS: Macadamia nut oil fatty acid phytosteryl 〇Plandol-LG1: Di (phytosteryl / octyldodecyl) lauroyl glutamate
〇Plandol-LG2: Di lauroyl glutamate (phytosteryl / octyldodecyl)
〇Plandol-LG3: Di-lauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
〇Plandol-LG4: Di (phytosteryl / octyldodecyl / behenyl) lauroyl glutamate
〇Phytocompo-PP: Hydrogenated lecithin, phytosterols 〇Phytocompo-C: Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
〇 Phytopresome MEL: Glycolipid, hydrogenated lecithin, BG, purified water 〇 Elcalactone DES: γ-docosalactone, diethyl sebacate 〇 Tremoist-TP: White jellyfish polysaccharide 〇 Tremoist-SL: White jellyfish polysaccharide aqueous solution (1%)

Claims (8)

A skin flora balance improver containing lanolin fatty acid or a salt thereof as an active ingredient. The salt of the lanolin fatty acid is a salt of the lanolin fatty acid and a metal selected from Na, K, Ca, Mg, Al and Zn; a salt of a basic amino acid selected from lysine, arginine, histidine and ornithine; ammonium, The skin indigenous bacterium balance improving agent according to claim 1, wherein the agent is one or more selected from salts with an organic base selected from triethanolamine and guanidine. Claim 1 characterized in that the salt of the lanolin fatty acid is one or more selected from salts of lanolin fatty acid and Na, K, Ca, Zn, ammonium, triethanolamine, arginine and guanidine. The agent for improving the balance of indigenous bacteria on the skin. The skin flora balance improving agent according to any one of claims 1 to 3, wherein the lanolin fatty acid is a soft lanolin fatty acid. The skin flora balance improving agent according to any one of claims 1 to 4, which has a proliferative effect on Staphylococcus epidermidis and an antibacterial effect on Staphylococcus aureus. A cosmetic or external skin flora containing the indigenous skin flora balance improving agent according to any one of claims 1 to 5. The cosmetic or external skin preparation according to claim 6, which is for improving rough skin. The cosmetic or external skin preparation according to claim 6, which is for improving atopic dermatitis.