JP2021054770A - Beauty composition - Google Patents
Beauty composition Download PDFInfo
- Publication number
- JP2021054770A JP2021054770A JP2019180774A JP2019180774A JP2021054770A JP 2021054770 A JP2021054770 A JP 2021054770A JP 2019180774 A JP2019180774 A JP 2019180774A JP 2019180774 A JP2019180774 A JP 2019180774A JP 2021054770 A JP2021054770 A JP 2021054770A
- Authority
- JP
- Japan
- Prior art keywords
- present
- composition
- pine bark
- preferable
- cosmetological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Images
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
本発明は、松樹皮及び特定の他の素材を含有する美容組成物に関する。 The present invention relates to cosmetological compositions containing pine bark and certain other materials.
生体内に余分な活性酸素が存在すると細胞が損傷することが知られている。活性酵素は、例えば、コラーゲン線維の架橋、ヒアルロン酸の断片化等を引き起こし、しわ増大や弾力性低下等の皮膚老化を促進する。このような活性酸素による生体への悪影響を防ぐため、抗酸化機能を有する素材が探求されている。 It is known that cells are damaged in the presence of excess active oxygen in the living body. The active enzyme causes, for example, collagen fiber cross-linking, hyaluronic acid fragmentation, and the like, and promotes skin aging such as increased wrinkles and decreased elasticity. In order to prevent such adverse effects on the living body due to active oxygen, a material having an antioxidant function has been sought.
例えば、松樹皮は、プロアントシアニジンを含有し、抗酸化作用を有することが知られている（特許文献１参照）。 For example, pine bark contains proanthocyanidins and is known to have an antioxidant effect (see Patent Document 1).
本発明の課題は、抗酸化作用が飛躍的に向上した美容組成物を提供することにある。 An object of the present invention is to provide a cosmetological composition having a dramatically improved antioxidant effect.
本発明者らは、上記課題を解決すべく鋭意検討した結果、松樹皮及び特定の他の素材を組み合わせることにより、抗酸化作用を飛躍的に向上させることができることを見いだし、本発明を完成するに至った。すなわち、松樹皮と、抗酸化作用がほとんどないか、その能力が小さい特定の他の成分を組み合わせることにより、抗酸化作用を飛躍的に向上させることができることを見いだした。 As a result of diligent studies to solve the above problems, the present inventors have found that the antioxidant action can be dramatically improved by combining pine bark and a specific other material, and complete the present invention. It came to. That is, it was found that the antioxidant activity can be dramatically improved by combining the pine bark with a specific other component having little or little antioxidant activity.
すなわち、本発明は、以下のとおりのものである。
［１］松樹皮と、ハーブ、セラミド及びセレンから選ばれる少なくとも１種の素材とを含有することを特徴とする美容組成物。
［２］抗酸化に用いられることを特徴とする［１］記載の美容組成物。
［３］経口用であることを特徴とする［１］又は［２］記載の美容組成物。
That is, the present invention is as follows.
[1] A cosmetological composition comprising pine bark and at least one material selected from herbs, ceramides and selenium.
[2] The cosmetological composition according to [1], which is used for antioxidants.
[3] The cosmetological composition according to [1] or [2], which is for oral use.
本発明の美容組成物は、非常に優れた抗酸化作用を有する。 The cosmetological composition of the present invention has a very excellent antioxidant effect.
本発明の組成物は、松樹皮と、ハーブ、セラミド及びセレンから選ばれる少なくとも１種の素材（他素材）とを含有することを特徴とする。松樹皮と共に用いられる他素材は、１種単独で用いてもよいし、２種以上組み合わせて用いてもよい。２種以上組み合せて用いる場合、松樹皮と相乗効果の高い他素材同士を組み合わせることが好ましい。 The composition of the present invention is characterized by containing pine bark and at least one material (other material) selected from herbs, ceramides and selenium. The other materials used together with the pine bark may be used alone or in combination of two or more. When two or more kinds are used in combination, it is preferable to combine pine bark and other materials having a high synergistic effect.
本発明の美容組成物は、優れた抗酸化作用（活性酸素消去作用）を有する。すなわち、皮膚等における活性酸素の発生を抑え、消去することができる。したがって、本発明の美容組成物は、皮膚のしわ防止、皮膚のはり・弾力低下防止、皮膚の保護、皮膚の保湿力向上、アンチエイジング等の美容効果を得ることができる。 The cosmetological composition of the present invention has an excellent antioxidant action (active oxygen scavenging action). That is, it is possible to suppress and eliminate the generation of active oxygen on the skin and the like. Therefore, the cosmetological composition of the present invention can obtain cosmetic effects such as prevention of wrinkles on the skin, prevention of elasticity and elasticity of the skin, protection of the skin, improvement of moisturizing power of the skin, and anti-aging.
以下、本発明の組成物に含まれる各素材（以下、本発明の素材ということがある）について説明する。
［松樹皮］
本発明で用いられる松樹皮の原料松としては、フランス海岸松（Ｐｉｎｕｓ Ｍａｒｔｉｍａ）、カラマツ、クロマツ、アカマツ、ヒメコマツ、ゴヨウマツ、チョウセンマツ、ハイマツ、リュウキュウマツ、ウツクシマツ、ダイオウマツ、シロマツ等を挙げることができ、これらの中でも、抗酸化作用の強いフランス海岸松を用いることが好ましい。
Hereinafter, each material contained in the composition of the present invention (hereinafter, may be referred to as the material of the present invention) will be described.
[Pine bark]
Examples of the raw material pine for the pine bark used in the present invention include French coastal pine (Pinus Martima), Karamatsu, Black pine, Red pine, Himekomatsu, Pinus parviflora, Pinus parviflora, High pine, Ryukyu pine, Utsukushima pine, Longleaf pine, White pine and the like. Among these, it is preferable to use French coastal pine, which has a strong antioxidative effect.
本発明においては、松樹皮を加工して用いることができ、松樹皮加工物としては、例えば、チップ状物、粉砕物、搾汁物、抽出物や、これらの乾燥粉末を挙げることができる。本発明において用いられる松樹皮は、製剤性を考慮すると、適用が容易であることから、粉砕物、搾汁物、抽出物又はこれらの乾燥粉末であることが好ましく、抗酸化作用の点から、抽出物又はその乾燥粉末であることがより好ましい。松樹皮加工物は、当業者により通常知られている方法によって製造したものでもよいし、市場に流通しているものであってもよい。例えば、株式会社東洋新薬製の松樹皮抽出物を用いることができる。 In the present invention, pine bark can be processed and used, and examples of the processed pine bark product include chips, crushed products, squeezed products, extracts, and dry powders thereof. The pine bark used in the present invention is preferably a pulverized product, a squeezed product, an extract or a dry powder thereof because it is easy to apply in consideration of the medicinal properties, and is extracted from the viewpoint of antioxidant action. More preferably, it is a product or a dry powder thereof. The processed pine bark product may be produced by a method generally known to those skilled in the art or may be commercially available. For example, a pine bark extract manufactured by Toyo Shinyaku Co., Ltd. can be used.
松樹皮抽出物を得る際に使用する抽出溶媒としては、例えば、水、有機溶媒、含水有機溶媒（含水エタノールといった含水アルコール）が挙げられる。有機溶媒としては、例えば、メタノール、エタノール、１−プロパノール、２−プロパノール、１−ブタノール、２−ブタノール、ブタン、アセトン、ヘキサン、シクロヘキサン、プロピレングリコール、含水エタノール、含水プロピレングリコール、エチルメチルケトン、グリセリン、酢酸メチル、酢酸エチル、ジエチルエーテル、ジクロロメタン、食用油脂、１，１，１，２−テトラフルオロエタン、及び１，１，２−トリクロロエテンが挙げられる。これらの水及び有機溶媒は単独で用いてもよいし、組み合わせて用いてもよい。抽出溶媒としては、水を用いることが好ましい。なお、抽出する際の溶媒の温度は、用いる溶媒の沸点以下であれば限定されない。 Examples of the extraction solvent used for obtaining the pine bark extract include water, organic solvents, and hydrous organic solvents (hydrous alcohols such as hydrous ethanol). Examples of the organic solvent include methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, butane, acetone, hexane, cyclohexane, propylene glycol, hydrous ethanol, hydrous propylene glycol, ethylmethylketone, and glycerin. , Methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible fats and oils, 1,1,1,2-tetrafluoroethane, and 1,1,2-trichloroethane. These water and organic solvent may be used alone or in combination. Water is preferably used as the extraction solvent. The temperature of the solvent at the time of extraction is not limited as long as it is equal to or lower than the boiling point of the solvent used.
松樹皮抽出物を得る方法については、特に限定はないが、例えば、加温抽出法、超臨界流体抽出法、液体二酸化炭素回分法、液体二酸化炭素還流法、超臨界二酸化炭素還流法等が挙げられる。また、複数の抽出方法を組み合わせてもよい。複数の抽出方法を組み合わせることにより、種々の組成の松樹皮抽出物を得ることが可能となる。 The method for obtaining the pine bark extract is not particularly limited, and examples thereof include a heating extraction method, a supercritical fluid extraction method, a liquid carbon dioxide fractionation method, a liquid carbon dioxide reflux method, and a supercritical carbon dioxide reflux method. Be done. Moreover, you may combine a plurality of extraction methods. By combining a plurality of extraction methods, it is possible to obtain pine bark extracts having various compositions.
超臨界流体抽出法とは、物質の気液の臨界点（臨界温度、臨界圧力）を超えた状態の流体である超臨界流体を用いて抽出を行う方法である。超臨界流体としては、二酸化炭素、エチレン、プロパン、亜酸化窒素（笑気ガス）等が用いられるが、二酸化炭素が好ましく用いられる。 The supercritical fluid extraction method is a method of extracting using a supercritical fluid which is a fluid in a state where the critical point (critical temperature, critical pressure) of the gas or liquid of a substance is exceeded. As the supercritical fluid, carbon dioxide, ethylene, propane, nitrous oxide (laughing gas) and the like are used, but carbon dioxide is preferably used.
超臨界流体抽出法では、目的成分を超臨界流体によって抽出する抽出工程と、目的成分と超臨界流体を分離する分離工程とを行う。分離工程では、圧力変化による抽出分離、温度変化による抽出分離、吸着剤、吸収剤を用いた抽出分離のいずれを行ってもよい。 In the supercritical fluid extraction method, an extraction step of extracting the target component with the supercritical fluid and a separation step of separating the target component and the supercritical fluid are performed. In the separation step, any of extraction separation due to pressure change, extraction separation due to temperature change, and extraction separation using an adsorbent and an absorbent may be performed.
また、エントレーナー添加法による超臨界流体抽出を行ってもよい。この方法は、抽出流体に、例えば、エタノール、プロパノール、ｎ−ヘキサン、アセトン、トルエン、その他の脂肪族低級アルコール類、脂肪族炭化水素類、芳香族炭化水素類、ケトン類を２〜２０Ｗ／Ｖ％程度添加し、この流体を用いて超臨界流体抽出を行うことによって、ＯＰＣ（Ｏｌｉｇｏｍｅｒｉｃ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎ：オリゴメリック・プロアントシアニジン）、カテキン類等の目的とする抽出物の抽出溶媒に対する溶解度を飛躍的に上昇させる、あるいは分離の選択性を増強させる方法であり、効率的な松樹皮抽出物を得る方法である。 In addition, supercritical fluid extraction by the entrainer addition method may be performed. In this method, for example, ethanol, propanol, n-hexane, acetone, toluene, other aliphatic lower alcohols, aliphatic hydrocarbons, aromatic hydrocarbons, and ketones are added to the extraction fluid at 2 to 20 W / V. By adding about% and performing supercritical fluid extraction using this fluid, the solubility of the target extract such as OPC (Oligometric acetone: oligomeric proanthocyanidin), catechins, etc. in the extraction solvent is dramatically increased. It is a method of allowing or enhancing the selectivity of separation, and is a method of obtaining an efficient pine bark extract.
超臨界流体抽出法は、比較的低い温度で操作できるため、高温で変質・分解する物質にも適用できるという利点、抽出流体が残留しないという利点、溶媒の循環利用が可能であるため、脱溶媒工程等が省略でき、工程がシンプルになるという利点がある。 Since the supercritical fluid extraction method can be operated at a relatively low temperature, it has the advantage that it can be applied to substances that deteriorate and decompose at high temperatures, the advantage that the extraction fluid does not remain, and the solvent can be recycled, so that the solvent is removed. There is an advantage that the process can be omitted and the process is simplified.
上記の抽出により得られた松樹皮抽出物を、カラム法又はバッチ法により精製することが安全性の面から好ましい。カラム法としては、例えば、ダイヤイオンＨＰ−２０、Ｓｅｐｈａｄｅｘ−ＬＨ２０、キチン等の吸着性担体を用いた精製方法が挙げられる。 From the viewpoint of safety, it is preferable to purify the pine bark extract obtained by the above extraction by a column method or a batch method. Examples of the column method include a purification method using an adsorptive carrier such as Diaion HP-20, Sephadex-LH20, and chitin.
本発明に用いられる松樹皮抽出物は、主な成分の一つとして、プロアントシアニジンを含有する。プロアントシアニジンは、フラバン−３−オール及び／又はフラバン−３，４−ジオールを構成単位とする重合度が２以上の縮重合体からなる化合物群である。 The pine bark extract used in the present invention contains proanthocyanidins as one of the main components. Proanthocyanidins are a group of compounds comprising flavan-3-ols and / or flavan-3,4-diols as constituent units and having a degree of polymerization of 2 or more.
本発明に用いられる松樹皮抽出物は、プロアントシアニジンとして重合度が２以上の縮重合体が含有されていることが好ましい。特に、重合度が低い縮重合体が多く含まれるプロアントシアニジンが好ましい。重合度の低い縮重合体としては、例えば、重合度が２〜３０の縮重合体（２〜３０量体）であり、重合度が２〜１０の縮重合体（２〜１０量体）が好ましく、重合度が２〜４の縮重合体（２〜４量体）がさらに好ましい。本明細書では、重合度が２〜４の重合体を、ＯＰＣ（ｏｌｉｇｏｍｅｒｉｃ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎ）という。本発明に用いられる松樹皮抽出物は、ＯＰＣを２０質量％以上含有することが好ましく、３０質量％以上含有することがより好ましく、４０質量％以上含有することがさらに好ましい。 The pine bark extract used in the present invention preferably contains a reduced polymer having a degree of polymerization of 2 or more as a proanthocyanidin. In particular, proanthocyanidins containing a large amount of a reduced polymer having a low degree of polymerization are preferable. Examples of the reduced polymer having a low degree of polymerization include a reduced polymer having a degree of polymerization of 2 to 30 (2 to 30-mer) and a polymer having a degree of polymerization of 2 to 10 (2 to 10-mer). Preferably, a reduced polymer having a degree of polymerization of 2 to 4 (2 to tetramer) is more preferable. In the present specification, a polymer having a degree of polymerization of 2 to 4 is referred to as OPC (oligomeric procyanidin). The pine bark extract used in the present invention preferably contains 20% by mass or more of OPC, more preferably 30% by mass or more, and further preferably 40% by mass or more.
［ハーブ］
本発明に用いられるハーブは、薬草や、料理、茶飲料、香料、保存料として用いられる植物である。具体的には、カモミール、セイヨウサンザシ、ドクダミ、ブドウ、ペパーミント、ローズヒップ、ハイビスカス、レモングラス、レモンバーム、マローブルー、ローズマリー、エキナセア、ラベンダー、タイム、シナモン等を挙げることができる。これらの中でも、ドクダミ、セイヨウサンザシ、カモミール、ブドウが好ましく、ドクダミ、セイヨウサンザシ、カモミール、及びブドウを併用することが特に好ましい。
[Herbs]
The herbs used in the present invention are herbs and plants used as cooking, tea beverages, flavors and preservatives. Specific examples include chamomile, hawthorn, houttuynia cordata, grapes, peppermint, rose hips, hibiscus, lemongrass, lemon balm, mallow blue, rosemary, echinacea, lavender, thyme, cinnamon and the like. Among these, Houttuynia cordata, hawthorn, chamomile and grapes are preferable, and Houttuynia cordata, hawthorn, chamomile and grapes are particularly preferable.
［カモミール］
カモミールは、学名が「Ｍａｔｒｉｃａｒｉａ ｃｈａｍｏｍｉｌｌａ」で、和名が「カミツレ」のキク科シカギク属の耐寒性一年草であり、ヨーロッパから西アジアにかけて分布している。カモミールの使用部位としては、地上部及び地下部が挙げられる。地上部としては、葉、茎、花、果実が挙げられ、地下部としては根が挙げられるが、本発明で用いるカモミールとしては、抗酸化作用が高いため、花を含むことが好ましい。
[chamomile]
Chamomile is a cold-tolerant annual plant belonging to the genus Mayweed of the Asteraceae family, whose scientific name is "Matrixaria chamomile" and whose Japanese name is "chamomile", and is distributed from Europe to West Asia. Examples of the parts where chamomile is used include above-ground parts and underground parts. Examples of the above-ground part include leaves, stems, flowers, and fruits, and examples of the underground part include roots. However, the chamomile used in the present invention preferably contains flowers because of its high antioxidant activity.
［セイヨウサンザシ］
セイヨウサンザシは、バラ科サンザシ属の植物である。セイヨウサンザシの使用部位としては、葉、茎、花、果実などが挙げられるが、本発明で用いるセイヨウサンザシとしては、抗酸化作用が高いため、葉、花、果実であることが好ましく、果実であることが特に好ましい。
[Hawthorn]
Hawthorn is a plant of the genus Hawthorn in the Rosaceae family. Examples of the site where the hawthorn is used include leaves, stems, flowers, and fruits. However, the hawthorn used in the present invention preferably has leaves, flowers, and fruits because of its high antioxidant activity. It is particularly preferable to have.
［ドクダミ］
ドクダミは、学名が「Ｈｏｕｔｔｕｙｎｉａ ｃｏｒｄａｔａ」のドクダミ科ドクダミ属の多年草である。ドクダミの使用部位としては、地上部及び地下部が挙げられる。地上部としては、葉、茎、花、果実が挙げられ、地下部としては根が挙げられる。本発明で用いるドクダミとしては、抗酸化作用が高いため、地上部であることが好ましく、花を含むことが特に好ましい。
[Houttuynia cordata]
Houttuynia is a perennial plant belonging to the genus Houttuynia in the family Houttuynia with the scientific name "Houttuynia cordata". Examples of the parts where Houttuynia cordata is used include above-ground parts and underground parts. The above-ground part includes leaves, stems, flowers and fruits, and the underground part includes roots. The Houttuynia cordata used in the present invention preferably has an above-ground part and particularly preferably contains flowers because it has a high antioxidant effect.
［ブドウ］
ブドウは、ブドウ科ブドウ属の植物であり、ブドウ（Ｖｉｔｉｓ ｖｉｎｉｆｅｒａ Ｌ．）、アメリカブドウ（Ｖｉｔｉｓ ｌａｂｒｕｓｃａ Ｌ．）、アマヅル（Ｖ．ｓａｃｃｈａｒｉｆｅｒａ Ｍａｋｉｎｏ）、エビヅル（Ｖ．ｆｉｃｉｆｏｌｉａ ｂｕｎｇｅ ｖａｒ．ｌｏｂａｔａ（Ｒｅｇｅｌ）Ｎａｋａｉ）、サンカクヅル（Ｖ．ｆｌｅｘｕｏｓａ Ｔｈｕｎｂ．）、ヤマブドウ（Ｖ．ｃｏｉｇｕｅｔｉａｅ Ｐｕｌｌｉａｔ）、欧・米雑種ブドウ（Ｖ．ｌａｂｒｕｓｃａｎａ Ｂａｉｌｅｙ）等を用いることができる。ブドウの使用部位としては、葉、茎、花、果実などが挙げられるが、本発明で用いるカモミールブドウとしては、抗酸化作用が高いため、葉であることが好ましい。
[Grape]
Grape is a plant of the genus Grapevine, grapes (Vitis vinifera L.), American grapes (Vitis lavrusca L.), amazuru (V. saccharifera Makino), shrimp (V. ficifolia bunge var. Lob). ), Vitis ficifolia (V. flexuosa Thumb.), Yama grape (V. coiguitiae Pluriat), European / American hybrid grape (V. labruscana Bailey) and the like can be used. Examples of the site where the grape is used include leaves, stems, flowers, fruits and the like, but the chamomile grape used in the present invention preferably has a leaf because of its high antioxidant activity.
本発明においては、収穫したハーブを加工して用いることができ、ハーブ加工物としては、例えば、チップ状物、粉砕物、搾汁物、抽出物や、これらの乾燥粉末を挙げることができる。本発明において用いられるハーブは、製剤性を考慮すると、適用が容易であることから、粉砕物、搾汁物、抽出物又はこれらの乾燥粉末であることが好ましく、抗酸化作用の点から、抽出物又はその乾燥粉末であることがより好ましい。ハーブ加工物は、当業者により通常知られている方法によって製造したものでもよいし、市場に流通しているものであってもよい。 In the present invention, the harvested herbs can be processed and used, and examples of the processed herb products include chips, crushed products, squeezed products, extracts, and dry powders thereof. The herb used in the present invention is preferably a pulverized product, a squeezed product, an extract or a dry powder thereof because it is easy to apply in consideration of formulation properties, and an extract from the viewpoint of antioxidant action. Or it is more preferably a dry powder thereof. The processed herb product may be produced by a method generally known to those skilled in the art or may be commercially available.
ハーブの抽出物は、適当な溶媒を用いて抽出することにより得ることができ、溶媒としては、例えば、水；エタノール、メタノール、イソプロパノール、ブタノールなどの低級アルコール；酢酸エチル、酢酸メチルなどの低級エステル；アセトン；これらと水との混合溶媒などが挙げられる。抽出溶媒の温度は、使用する溶媒に応じて室温〜沸点以下で適宜設定することができる。本発明においては有機溶媒と水の混合溶媒を使用することができ、混合溶媒としては、例えば、エタノール、メタノール、イソプロパノール、ブタノール、酢酸エチル、酢酸メチル、アセトンと、水との混合溶媒を用いることができる。抽出溶媒の温度は、使用する溶媒に応じて室温〜沸点以下で適宜設定することができる。本発明においては、抗酸化作用の点から、熱水抽出物が好ましい。 The herb extract can be obtained by extracting with a suitable solvent, and the solvent includes, for example, water; lower alcohols such as ethanol, methanol, isopropanol and butanol; lower esters such as ethyl acetate and methyl acetate. Acetone; a mixed solvent of these with water and the like. The temperature of the extraction solvent can be appropriately set from room temperature to below the boiling point depending on the solvent used. In the present invention, a mixed solvent of an organic solvent and water can be used, and as the mixed solvent, for example, a mixed solvent of ethanol, methanol, isopropanol, butanol, ethyl acetate, methyl acetate, acetone and water is used. Can be done. The temperature of the extraction solvent can be appropriately set from room temperature to below the boiling point depending on the solvent used. In the present invention, a hot water extract is preferable from the viewpoint of antioxidant action.
［セラミド］
本発明に用いられるセラミドとしては、セラミド１、セラミド２、セラミド３等のヒト型セラミドの他、牛、馬、豚等の脳、脊髄等から抽出した動物由来のセラミド、小麦、稲、大豆、ホウレンソウ、トウモロコシ、こんにゃく、パイナップル等から抽出した植物由来のセラミドを用いることができる。また、本発明に用いられるセラミドとしては、糖セラミドであってもよく、具体的に例えば、ガラクトシルセラミド、グルコシルセラミド等の単糖が結合したものや、オリゴ糖が結合したものを挙げることができる。本発明の美容組成物においては、植物由来のセラミドを用いることが好ましく、小麦、トウモロコシ、稲などのイネ科植物由来のグルコシルセラミドを用いることが更に好ましく、その中でも、抗酸化作用の点から、稲から採取される米や種子から抽出したグルコシルセラミドを用いることが特に好ましい。抽出に使用される溶媒としては、例えば、水；エタノール、メタノール、イソプロパノール、ブタノールなどの低級アルコール；酢酸エチル、酢酸メチルなどの低級エステル；アセトン；これらと水との混合溶媒などが挙げられる。抽出溶媒の温度は、使用する溶媒に応じて室温〜沸点以下で適宜設定することができる。本発明においては、抽出溶媒としては、有効成分を効率よく抽出できることから、エタノール又は含水エタノールが好ましい。
[Ceramide]
The ceramide used in the present invention includes human ceramides such as ceramide 1, ceramide 2, and ceramide 3, animal-derived ceramides extracted from the brain and spinal cord of cows, horses, pigs, etc., wheat, rice, soybeans, and the like. Plant-derived ceramides extracted from spinal cord, corn, konjac, pineapple and the like can be used. Further, the ceramide used in the present invention may be sugar ceramide, and specific examples thereof include those to which monosaccharides such as galactosylceramide and glucosylceramide are bound, and those to which oligosaccharides are bound. .. In the beauty composition of the present invention, it is preferable to use a plant-derived ceramide, and it is more preferable to use a glucosylceramide derived from a gramineous plant such as wheat, corn, or rice. Among them, from the viewpoint of antioxidant action, it is preferable to use. It is particularly preferable to use glucosylceramide extracted from rice or seeds collected from rice. Examples of the solvent used for extraction include water; lower alcohols such as ethanol, methanol, isopropanol and butanol; lower esters such as ethyl acetate and methyl acetate; acetone; and a mixed solvent of these and water. The temperature of the extraction solvent can be appropriately set from room temperature to below the boiling point depending on the solvent used. In the present invention, ethanol or hydrous ethanol is preferable as the extraction solvent because the active ingredient can be efficiently extracted.
［セレン］
セレンは、ミネラルの１種であり、ヒトの必須栄養素である。本発明に用いるセレンとしては、セレン元素を含むセレン化合物の形態や、セレン化合物を含む酵母を挙げることができる。具体的には、亜セレン酸ナトリウム、セレノメチオニン、セレン強化酵母を例示することができ、市販品を用いることができる。
[selenium]
Selenium is a mineral and an essential human nutrient. Examples of the selenium used in the present invention include the form of a selenium compound containing a selenium element and yeast containing a selenium compound. Specifically, sodium selenite, selenomethionine, and selenium-enriched yeast can be exemplified, and commercially available products can be used.
本発明の美容組成物は、例えば、医薬品（医薬部外品を含む）や、特定保健用食品、栄養機能食品、機能性表示食品等の所定機関より効能の表示が認められた機能性食品などのいわゆる健康食品や、化粧品や、トイレタリー用品等として用いることができる。 The beauty composition of the present invention includes, for example, pharmaceuticals (including non-pharmaceutical products), functional foods whose efficacy has been approved by a predetermined organization such as foods for specified health use, foods with nutritional function, foods with functional claims, etc. It can be used as so-called health foods, cosmetics, toiletry products, and the like.
本発明の美容組成物は、美容用途に用いることができ、かかる美容用組成物としては、本発明の素材を含有し、美容に用いられる点において、製品として他の製品と区別することができるものであれば特に制限されるものではなく、例えば、本発明に係る製品の本体、包装、説明書、宣伝物（広告媒体）のいずれかに、抗酸化作用等の美容効果がある旨を表示したものが本発明の範囲に含まれる。なお、本発明の美容用組成物は、製品の包装等に、本発明の本発明の素材が有効成分として表示されているものに限られない。例えば、有効成分を特定していないものであってもよい。また、一般的な食品であっても、用途を示唆して製造販売されるものは本発明の範囲に含まれる。 The cosmetological composition of the present invention can be used for cosmetological purposes, and the cosmetological composition contains the material of the present invention and can be distinguished from other products as a product in that it is used for cosmetology. It is not particularly limited as long as it is a product, and for example, it is indicated that any of the main body, packaging, instruction manual, and advertising material (advertising medium) of the product according to the present invention has a cosmetic effect such as an antioxidant effect. Is included in the scope of the present invention. The cosmetological composition of the present invention is not limited to the one in which the material of the present invention of the present invention is displayed as an active ingredient on the packaging of the product or the like. For example, the active ingredient may not be specified. Further, even general foods that are manufactured and sold by suggesting their uses are included in the scope of the present invention.
また、本発明の美容組成物は、抗酸化用途に用いることができ、かかる抗酸化用組成物としては、本発明の素材を含有し、抗酸化に用いられる点において、製品として他の製品と区別することができるものであれば特に制限されるものではなく、例えば、本発明に係る製品の本体、包装、説明書、宣伝物（広告媒体）のいずれかに、抗酸化作用等の美容効果がある旨を表示したものが本発明の範囲に含まれる。なお、本発明の美容用組成物は、製品の包装等に、本発明の本発明の素材が有効成分として表示されているものに限られない。例えば、有効成分を特定していないものであってもよい。また、一般的な食品であっても、用途を示唆して製造販売されるものは本発明の範囲に含まれる。 In addition, the beauty composition of the present invention can be used for antioxidant applications, and the antioxidant composition contains the material of the present invention and is used for antioxidants, and is different from other products as a product. It is not particularly limited as long as it can be distinguished, and for example, a beauty effect such as an antioxidant effect can be applied to any of the main body, packaging, instruction manual, and promotional material (advertising medium) of the product according to the present invention. The indication that there is is included in the scope of the present invention. The cosmetological composition of the present invention is not limited to the one in which the material of the present invention of the present invention is displayed as an active ingredient on the packaging of the product or the like. For example, the active ingredient may not be specified. Further, even general foods that are manufactured and sold by suggesting their uses are included in the scope of the present invention.
また、本発明の美容組成物は、ＤＰＰＨラジカル消去活性用途に用いることができ、かかるＤＰＰＨラジカル消去活性用組成物としては、本発明の素材を含有し、ＤＰＰＨラジカル消去活性に用いられる点において、製品として他の製品と区別することができるものであれば特に制限されるものではなく、例えば、本発明に係る製品の本体、包装、説明書、宣伝物（広告媒体）のいずれかに、ＤＰＰＨラジカル消去活性作用等の美容効果がある旨を表示したものが本発明の範囲に含まれる。なお、本発明の美容用組成物は、製品の包装等に、本発明の本発明の素材が有効成分として表示されているものに限られない。例えば、有効成分を特定していないものであってもよい。また、一般的な食品であっても、用途を示唆して製造販売されるものは本発明の範囲に含まれる。 Further, the beauty composition of the present invention can be used for DPPH radical scavenging activity, and the composition for DPPH radical scavenging activity contains the material of the present invention and is used for DPPH radical scavenging activity. The product is not particularly limited as long as it can be distinguished from other products. For example, DPPH can be applied to any of the main body, packaging, description, and promotional material (advertising medium) of the product according to the present invention. The scope of the present invention includes those indicating that they have a cosmetic effect such as a radical scavenging activity. The cosmetological composition of the present invention is not limited to the one in which the material of the present invention of the present invention is displayed as an active ingredient on the packaging of the product or the like. For example, the active ingredient may not be specified. Further, even general foods that are manufactured and sold by suggesting their uses are included in the scope of the present invention.
具体的に、いわゆる健康食品においては、「肌を守る」、「しわが気になる方に」、「ストレスに負けない肌に」、「美容にうれしい」、「肌にうれしい」、「老化防止に」、「アンチエイジングに」、「酸化ストレスの軽減に」、「体内の有害物質を排除したい方に」、「活性酸素の軽減に」等を表示したものを例示することができる。 Specifically, in so-called health foods, "protecting the skin", "for those who are worried about wrinkles", "for stress-resistant skin", "good for beauty", "good for skin", "anti-aging" For example, "for anti-aging", "for reducing oxidative stress", "for those who want to eliminate harmful substances in the body", "for reducing active oxygen" and the like.
本発明の美容組成物は、上記の効果が気になる人であれば性別や年齢に関係なく摂取することができるが、本発明の美容組成物の効果をより有効に享受することができることから、女性が摂取することが望ましく、３０代以降の女性が摂取することがより望ましい。 The beauty composition of the present invention can be ingested by a person who is concerned about the above effects regardless of gender or age, but the effects of the beauty composition of the present invention can be enjoyed more effectively. , It is desirable for women to take it, and it is more desirable for women in their thirties or older to take it.
本発明の美容組成物が経口剤の場合、その形態としては、例えば、錠状、カプセル状、粉末状、顆粒状、液状、粒状、棒状、板状、ブロック状、固形状、丸状、ペースト状、クリーム状、カプレット状、ゲル状、チュアブル錠状、スティック状等を挙げることができる。これらの中でも、錠状、カプセル状、粉末状、顆粒状、丸状、チュアブル錠状の形態が好ましく、錠状、カプセル状、丸状、チュアブル錠状がより好ましい。 When the cosmetological composition of the present invention is an oral preparation, the forms thereof include, for example, tablets, capsules, powders, granules, liquids, granules, rods, plates, blocks, solids, rounds, and pastes. Examples include a shape, a cream shape, a capsule shape, a gel shape, a chewable tablet shape, and a stick shape. Among these, the tablet-shaped, capsule-shaped, powder-shaped, granular-shaped, round-shaped, and chewable tablet-shaped forms are preferable, and the tablet-shaped, capsule-shaped, round-shaped, and chewable tablet-shaped are more preferable.
本発明の組成物を錠状、丸状、チュアブル錠状とする場合、賦形剤、滑沢剤、流動化剤のいずれか１種以上を添加することにより、成型性を高めるとともに得られた錠剤、丸剤又はチュアブル錠剤の保存安定性を向上するため、好ましい。特に、賦形剤及び滑沢剤を使用することで保存安定性をより高めることができる。 When the composition of the present invention is in the form of tablets, pills, or chewable tablets, it was obtained by adding one or more of excipients, pills, and fluidizing agents to improve moldability. It is preferable because it improves the storage stability of tablets, pills or chewable tablets. In particular, storage stability can be further enhanced by using excipients and lubricants.
賦形剤とは、組成物の取扱いあるいは成形の向上や服用を便利にするために加えるものである。本発明に使用できる賦形剤としては特に制限はなく、例えば、デンプン、アルファー化デンプン、部分アルファー化デンプン、デンプン分解物等のデンプン又はその誘導体、結晶セルロース、糖アルコール、乳糖、ビール酵母、低置換度ヒドロキシプロピルセルロース、ヒドロキシプロピルセルロース、精製白糖、軽質無水ケイ酸、ケイ酸カルシウム、酸化チタン、沈降炭酸カルシウム等などが挙げられる。これらは、１種単独で使用してもよいし、２種以上を併用してもよい。 Excipients are added to improve the handling or molding of the composition and to make it more convenient to take. The excipient that can be used in the present invention is not particularly limited, and is, for example, starch, pregelatinized starch, partially pregelatinized starch, starch such as starch decomposition product or a derivative thereof, crystalline cellulose, sugar alcohol, lactose, beer yeast, low. Substitution degree Hydroxypropyl cellulose, hydroxypropyl cellulose, purified sucrose, light anhydrous silicic acid, calcium silicate, titanium oxide, precipitated calcium carbonate and the like can be mentioned. These may be used alone or in combination of two or more.
滑沢剤とは、錠剤用の粉末を圧縮する際に打錠機杵臼と錠剤間の摩擦を緩和し、スティッキングなどの打錠障害を防ぐために使用するものである。本発明に使用できる滑沢剤としては、上記目的を達成することが可能な成分であれば特に制限はなく、例えば、ステアリン酸、ステアリン酸カルシウム、ステアリン酸マグネシウム等のステアリン酸又はその塩、フマル酸ステアリルナトリウム、ショ糖脂肪酸エステル、タルク、ポリエチレングリコール、植物油脂、硬化油などが挙げられる。これらは、１種単独で使用してもよく、２種以上を併用してもよい。 The lubricant is used to alleviate the friction between the tableting machine pestle and the tablet when compressing the powder for tablets, and to prevent tableting obstacles such as sticking. The lubricant that can be used in the present invention is not particularly limited as long as it is a component capable of achieving the above object. For example, stearic acid such as stearic acid, calcium stearate, magnesium stearate or a salt thereof, fumaric acid. Examples thereof include stearyl sodium, sucrose fatty acid ester, talc, polyethylene glycol, vegetable oil and fat, and hydrogenated oil. These may be used alone or in combination of two or more.
流動化剤とは、混合末や顆粒の流動性を改善するために使用するものである。本発明に使用できる流動化剤としては特に制限はなく、例えば二酸化ケイ素、ケイ酸アルミニウム、ケイ酸アルミン酸マグネシウム、リン酸カルシウム、炭酸マグネシウム、酸化マグネシウムなどが挙げられる。これらは、１種単独で使用してもよいし、２種以上を併用してもよい。本発明において、賦形剤、滑沢剤、流動化剤はいずれも市販品を使用することができる。 The fluidizing agent is used to improve the fluidity of mixed powders and granules. The fluidizing agent that can be used in the present invention is not particularly limited, and examples thereof include silicon dioxide, aluminum silicate, magnesium silicate aluminate, calcium phosphate, magnesium carbonate, and magnesium oxide. These may be used alone or in combination of two or more. In the present invention, commercially available products can be used as the excipient, the lubricant, and the fluidizing agent.
本発明の美容組成物が外用剤の場合、その形態としては、例えば、ローション状、乳液状、ゲル状、クリーム状、軟膏状、粉末状、顆粒状等を挙げることができる。具体的には、化粧水、化粧クリーム、乳液、クリーム、パック、ヘアトニック、ヘアクリーム、シャンプー、ヘアリンス、トリートメント、ボディシャンプー、洗顔剤、石鹸、ファンデーション、白粉、口紅、リップグロス、頬紅、アイシャドー、整髪料、育毛剤、水性軟膏、油性軟膏、目薬、アイウォッシュ、シップ、ジェルなどが挙げられる。また、口腔へ適用する場合は、歯磨剤、マウスウォッシュ、スプレーなどが挙げられる。 When the beauty composition of the present invention is an external preparation, examples thereof include lotion, emulsion, gel, cream, ointment, powder, and granules. Specifically, lotions, makeup creams, emulsions, creams, packs, hair tonics, hair creams, shampoos, hair rinses, treatments, body shampoos, facial cleansers, soaps, foundations, white powder, lipsticks, lip glosses, blushers, eye shadows. , Hair styling products, hair restorers, water-based ointments, oil-based ointments, eye drops, eye wash, ships, gels, etc. When applied to the oral cavity, dentifrice, mouthwash, spray and the like can be mentioned.
本発明の美容組成物における本発明の素材の含有量としては、その効果の奏する範囲で適宜含有させればよい。 The content of the material of the present invention in the beauty composition of the present invention may be appropriately contained within the range in which the effect is exhibited.
具体的には、本発明の美容組成物が錠状、丸状、カプセル状、チュアブル錠状の場合には、本発明の素材が乾燥質量換算で全体の０．０００００１〜６０質量％含まれていることが好ましく、０．００００１〜５０質量％含まれていることがより好ましく、０．０００１〜４０質量％含まれていることがさらに好ましく、抗酸化作用の点から、０．０１〜３０質量％含まれていることが特に好ましい。 Specifically, when the beauty composition of the present invention is in the form of a tablet, a round shape, a capsule shape, or a chewable tablet shape, the material of the present invention is contained in an amount of 0.000001 to 60% by mass in terms of dry mass. It is preferably contained in an amount of 0.00001 to 50% by mass, more preferably 0.0001 to 40% by mass, and 0.01 to 30% by mass from the viewpoint of antioxidant action. % Is particularly preferable.
本発明の美容組成物が粉末状、顆粒状の場合、本発明の素材が乾燥質量換算で全体の０．０００００１〜１００質量％含まれていることが好ましく、０．００００１〜９０質量％含まれていることがより好ましく、０．０００２〜８０質量％含まれていることがさらに好ましく、抗酸化作用の点から、０．０１〜７０質量％含まれていることが特に好ましい。 When the beauty composition of the present invention is in the form of powder or granules, the material of the present invention is preferably contained in an amount of 0.000001 to 100% by mass, preferably 0.00001 to 90% by mass, in terms of dry mass. It is more preferable that it is contained in an amount of 0.0002 to 80% by mass, and it is particularly preferable that it is contained in an amount of 0.01 to 70% by mass from the viewpoint of antioxidant action.
本発明の美容組成物が液状の飲料の場合、本発明の素材が乾燥質量換算で全体の０．００００００１〜５０質量％含まれていることが好ましく、０．００００１〜２５質量％含まれていることがより好ましく、０．０００２〜１０質量％含まれていることがさらに好ましく、抗酸化作用の点から、０．００１〜５質量％含まれていることが特に好ましい。 When the beauty composition of the present invention is a liquid beverage, the material of the present invention is preferably contained in an amount of 0.000000001 to 50% by mass, preferably 0.00001 to 25% by mass, in terms of dry mass. It is more preferable that it is contained in an amount of 0.0002 to 10% by mass, and it is particularly preferable that it is contained in an amount of 0.001 to 5% by mass from the viewpoint of antioxidant action.
本発明の美容組成物が経口剤の場合、摂取量としては特に制限はないが、成人の１日当たり、本発明の素材の摂取量が、１０ｍｇ／日以上となるように摂取することが好ましく、２０ｍｇ／日以上となるように摂取することがより好ましく、抗酸化作用の点から、３０ｍｇ／日以上となるように摂取することがさらに好ましい。その上限は、例えば、１０００００ｍｇ／日であり、好ましくは８００００ｍｇ／日であり、より好ましくは６００００ｍｇ／日である。 When the cosmetological composition of the present invention is an oral preparation, the intake amount is not particularly limited, but it is preferable to take the material of the present invention so that the intake amount of the material of the present invention is 10 mg / day or more per day for an adult. It is more preferable to take it at 20 mg / day or more, and it is further preferable to take it at 30 mg / day or more from the viewpoint of antioxidant action. The upper limit is, for example, 100,000 mg / day, preferably 80,000 mg / day, and more preferably 60,000 mg / day.
本発明の美容組成物が経口剤の場合、１日の摂取量が前記摂取量となるように適宜設計すればよく、１回で摂取してもよいし、複数回に分けて摂取してもよい。例えば、錠剤、カプセル剤、丸剤又はチュアブル錠剤の場合は１日あたり１〜４回の摂取回数とし、合計量として前記摂取量が摂取できればよく、飲料の場合、１日の摂取量に前記摂取量が配合されていればよい。本発明の美容組成物は、１日の摂取量が前記摂取量となるように、１つの容器に、又は例えば２〜３の複数の容器に分けて、１日分として収容することができる。 When the cosmetological composition of the present invention is an oral preparation, it may be appropriately designed so that the daily intake is the above-mentioned intake amount, and it may be taken once or divided into a plurality of times. Good. For example, in the case of tablets, capsules, pills or chewable tablets, the number of intakes should be 1 to 4 times a day, and the total amount should be the intake, and in the case of beverages, the intake should be the daily intake. It suffices if the amount is mixed. The cosmetological composition of the present invention can be contained in one container or divided into a plurality of containers, for example, 2 to 3 so that the daily intake becomes the above-mentioned intake, and can be contained as one day's worth.
本発明の美容組成物が外用剤の場合、本発明の素材が乾燥質量換算で全体の０．００００００１〜５０質量％含まれていることが好ましく、０．０００００１〜２０質量％含まれていることがより好ましく、０．００００１〜１０質量％含まれていることがさらに好ましく、抗酸化作用の点から、０．０００１〜５質量％含まれていることが特に好ましい。 When the beauty composition of the present invention is an external preparation, the material of the present invention is preferably contained in an amount of 0.000000001 to 50% by mass, preferably 0.000001 to 20% by mass, in terms of dry mass. Is more preferable, and 0.00001 to 10% by mass is more preferable, and 0.0001 to 5% by mass is particularly preferable from the viewpoint of antioxidant action.
本発明の美容組成物が外用剤である場合、使用量としては特に制限はなく、使用対象個体の年齢、体重、体質等の様々な要因を考慮して適宜選択することができる。 When the beauty composition of the present invention is an external preparation, the amount used is not particularly limited and can be appropriately selected in consideration of various factors such as the age, weight and constitution of the individual to be used.
また、松樹皮及び他素材の配合質量比としては、乾燥質量換算で、１：０．００００１〜２５の範囲であることが好ましく、１：０．０００１〜１０の範囲であることがより好ましく、１：０．００１〜５の範囲であることがさらに好ましく、１：０．００１〜２．５の範囲であることが特に好ましい。 The blending mass ratio of the pine bark and other materials is preferably in the range of 1: 0.00001 to 25, more preferably in the range of 1: 0.0001 to 10 in terms of dry mass. It is more preferably in the range of 1: 0.001 to 5, and particularly preferably in the range of 1: 0.001 to 2.5.
本発明の美容組成物は、必要に応じて、本発明の素材以外の他の成分を添加して、公知の方法によって製造することができる。
本発明の美容組成物が経口剤の場合、他の成分としては、例えば、水溶性ビタミン（ビタミンＢ１、Ｂ２、Ｂ３、Ｂ５、Ｂ６、Ｂ７、Ｂ９、Ｂ１２、Ｂ１３、Ｂ１５、Ｂ１７、ビタミンＣ、ビタミンＰ、コリン、イノシトール、ＰＡＢＡ）、脂溶性ビタミン（ビタミンＡ、ビタミンＤ、ビタミンＥ、ビタミンＫ）等のビタミン類；マグネシウム、リン、亜鉛、鉄等のミネラル類；タウリン、ニンニク等に含まれる含硫化合物；ヘスペリジン、ケルセチン等のフラバノイド或いはフラボノイド類；コラーゲン等のタンパク質；ペプチド；アミノ酸；動物性油脂；植物性油脂；動物・植物の粉砕物又は抽出物等を挙げることができる。
The cosmetological composition of the present invention can be produced by a known method by adding components other than the material of the present invention, if necessary.
When the beauty composition of the present invention is an oral preparation, other components include, for example, water-soluble vitamins (vitamins B1, B2, B3, B5, B6, B7, B9, B12, B13, B15, B17, vitamin C, etc. Vitamins such as vitamin P, choline, inositol, PABA), fat-soluble vitamins (vitamin A, vitamin D, vitamin E, vitamin K); minerals such as magnesium, phosphorus, zinc, iron; contained in taurine, garlic, etc. Sulfur-containing compounds; flavanoids or flavonoids such as hesperidin and quercetin; proteins such as collagen; peptides; amino acids; animal fats and oils; vegetable fats and oils; crushed products or extracts of animals and plants.
本発明の美容組成物が外用剤の場合、添加できる成分としては、種々の薬効成分（活性酸素除去剤、抗酸化剤、抗炎症剤、細胞賦活剤、ビタミン剤、ホルモン剤、これらの作用を有する動植物由来の抽出物など）、他の油剤（リノール酸、リノレン酸、パルミチン酸、ＤＨＡ、ＥＰＡなどの不飽和脂肪酸およびその誘導体、亜麻仁油、ヤシ油、ホホバ油、オリーブ油、スクワラン、スクワレン、馬油、コメヌカ油、ヒマシ油などの動植物より抽出された油およびその誘導体など）、保湿剤（コラーゲンまたはその分解物、カロットエキスなどに含まれるコラーゲン類似ペプチド、大豆ペプチド、アミノ酸、ヒアルロン酸などのムコ多糖類、コンドロイチンなどのアミノ糖、トレハロースなどの糖類、海藻類、アルギン酸、グルコマンナン、ペクチンなどの水溶性食物繊維など）、界面活性剤（レシチンや脂肪酸エステル、アミノ酸誘導体など）、紫外線吸収剤（酸化亜鉛、酸化チタンなど）、紫外線吸収促進剤などを挙げることができる。 When the beauty composition of the present invention is an external preparation, various medicinal ingredients (active oxygen remover, antioxidant, anti-inflammatory agent, cell activator, vitamin agent, hormonal agent, and their actions can be added. Other oils (such as extracts derived from animals and plants), unsaturated amino acids such as alginic acid, linolenic acid, palmitic acid, DHA, EPA and their derivatives, flaxseed oil, palm oil, jojoba oil, olive oil, squalane, squalane, horse Oils, rice bran oil, oils extracted from animals and plants such as linseed oil and their derivatives, etc.), moisturizers (collagen or its decomposition products, collagen-like peptides contained in carrot extract, soybean peptides, amino acids, hyaluronic acid, etc. Polysaccharides, amino sugars such as chondroitin, sugars such as trehalose, seaweeds, alginic acid, glucomannan, water-soluble dietary fibers such as pectin, etc.), surfactants (lecithin, fatty acid esters, amino acid derivatives, etc.), ultraviolet absorbers (ultraviolet absorbers, etc.) (Zinc oxide, titanium oxide, etc.), UV absorption accelerator, etc. can be mentioned.
［試験１：抗酸化作用の評価］
以下に記載する方法により、ＤＰＰＨラジカル消去活性を測定し、本発明の組成物の抗酸化作用を評価した。
[Test 1: Evaluation of antioxidant activity]
The DPPH radical scavenging activity was measured by the method described below, and the antioxidant activity of the composition of the present invention was evaluated.
（被験物質）
松樹皮として、フランス海岸松樹皮の熱水抽出物（乾燥粉末）を用いた。
ハーブとして、カモミール、セイヨウサンザシ、ドグダミ及びブドウ葉の４種類のハーブから熱水抽出した混合ハーブ抽出物を用いた。
セラミドとして、グルコシルセラミドを１０．０％以上含有するセラミド含有米抽出物（乾燥粉末）を用いた。
セレンとして、Ｓｅを０．２％以上含むセレン含有酵母（粉末）を用いた。
(Test substance)
As the pine bark, a hot water extract (dry powder) of French coastal pine bark was used.
As the herbs, a mixed herb extract extracted with hot water from four kinds of herbs, chamomile, hawthorn, dogdami and grape leaves, was used.
As the ceramide, a ceramide-containing rice extract (dry powder) containing 10.0% or more of glucosyl ceramide was used.
As selenium, selenium-containing yeast (powder) containing 0.2% or more of Se was used.
（被験物質溶液および、０．１ｍＭＤＰＰＨ溶液の調製）
被験物質溶液は超純水にて調製した。単体の溶液に関しては、１０ｍｇ／ｍＬのハーブ、セラミドおよびセレンを２倍で段階希釈したものを試験に供した。組み合わせ溶液に関しては、１ｍｇ／ｍＬの松樹皮と２０ｍｇ／ｍＬのハーブ、セラミドおよびセレンをそれぞれ１：１で混合したものを、０．５ｍｇ／ｍＬの松樹皮を用いて２倍で段階希釈したものを試験に供した。試験溶液における被験物質濃度は、添加濃度を１００倍に希釈した濃度となる。
ＤＰＰＨ溶液は１００％エタノールで調整し、０．１ｍＭＤＰＰＨとしたものを使用した。
(Preparation of test substance solution and 0.1 mM DPPH solution)
The test substance solution was prepared with ultrapure water. For a single solution, 10 mg / mL herbs, ceramides and selenium were serially diluted 2-fold for testing. The combination solution is a 1: 1 mixture of 1 mg / mL pine bark and 20 mg / mL herbs, ceramides and selenium, each serially diluted 2-fold with 0.5 mg / mL pine bark. Was subjected to the test. The concentration of the test substance in the test solution is a concentration obtained by diluting the added
The DPPH solution was adjusted with 100% ethanol to make 0.1 mM DPPH.
（ＤＰＰＨラジカル消去活性の測定）
被験物質溶液、０．１ｍＭＤＰＰＨ及び１００％エタノールを表１に示す割合で混合し、転倒混和にて撹拌した。２０分間室温にてインキュベートした後、９６ウェルプレートに２００μＬずつ移した。プレートリーダーにて５１６ｎｍにおける吸光度を測定し、次の式によりＤＰＰＨラジカル消去活性（％）を算出した。
また、コントロールにおけるＤＰＰＨラジカル消去活性を１００とした。
(Measurement of DPPH radical scavenging activity)
The test substance solution, 0.1 mM DPPH and 100% ethanol were mixed at the ratios shown in Table 1 and stirred by inversion mixing. After incubating for 20 minutes at room temperature, 200 μL was transferred to a 96-well plate. The absorbance at 516 nm was measured with a plate reader, and the DPPH radical scavenging activity (%) was calculated by the following formula.
The DPPH radical scavenging activity in the control was set to 100.
ＤＰＰＨラジカル消去活性（％）
＝(試験溶液test−試験溶液 blank) / (コントロール test−コントロール blank)×100
DPPH radical scavenging activity (%)
= (Test solution test − Test solution blank ) / (Control test − Control blank ) × 100
（式中、試験溶液 test：試験溶液（ｔｅｓｔ）の吸光度
試験溶液 blank：試験溶液（ｂｌａｎｋ）の吸光度
コントロール test：コントロール（ｔｅｓｔ）の吸光度
コントロール blank：コントロール（ｂｌａｎｋ）の吸光度）
(In the formula, test solution test : absorbance of test solution (test) Test solution blank : absorbance control of test solution (blank) test: absorbance control of control (test) blank : absorbance of control (blank))
（測定結果）
松樹皮のＤＰＰＨラジカル消去活性率を１００とした場合の、ＤＰＰＨラジカル消去活性の測定結果を図１〜図３に示す。数値がプラスの場合、コントロールに比べてＤＰＰＨラジカル消去活性が高いことを意味し、マイナスの場合、コントロールに比べてＤＰＰＨラジカル消去活性が低いことを意味する。ハーブを単独で添加した場合、ＤＰＰＨラジカル消去活性が若干認められたものの、セラミド及びセレンをそれぞれ単独で添加した場合には、ＤＰＰＨラジカル消去活性は全く認められなかった。一方、松樹皮と、ハーブ、セラミド及びセレンの各成分とを組み合わせた場合、ＤＰＰＨラジカル消去活性が相乗的に向上した。
以上より、松樹皮と、ハーブ、セラミド及びセレンの各素材とを組み合わせることにより、抗酸化作用が飛躍的に向上することが明らかとなった。したがって、本発明の組成物は、抗酸化作用を有する美容組成物として極めて有用である。
(Measurement result)
The measurement results of the DPPH radical scavenging activity when the DPPH radical scavenging activity rate of the pine bark is 100 are shown in FIGS. 1 to 3. A positive value means that the DPPH radical scavenging activity is higher than that of the control, and a negative value means that the DPPH radical scavenging activity is lower than that of the control. When the herbs were added alone, some DPPH radical scavenging activity was observed, but when ceramide and selenium were added alone, no DPPH radical scavenging activity was observed. On the other hand, when pine bark was combined with each component of herbs, ceramides and selenium, the DPPH radical scavenging activity was synergistically improved.
From the above, it was clarified that the antioxidant action is dramatically improved by combining the pine bark with the herbs, ceramides and selenium materials. Therefore, the composition of the present invention is extremely useful as a cosmetological composition having an antioxidant effect.
以下に本発明の種々の態様の例を挙げるが、本発明の技術的範囲はこれらに限定されるものではない。 Examples of various aspects of the present invention will be given below, but the technical scope of the present invention is not limited thereto.
＜製造例１〜製造例５＞
下記表２の配合にて、松樹皮と、本発明の他素材を配合して、均一になるように混合した後、打錠装置を用いて成形することによって錠剤を製造した（１粒あたり２５０ｍｇ）。得られた飲食用組成物を摂取したところ、美容効果の高い組成物が得られた。
<Manufacturing Examples 1 to 5>
In the formulation shown in Table 2 below, pine bark and other materials of the present invention were blended, mixed so as to be uniform, and then molded using a tableting device to produce tablets (250 mg per tablet). ). When the obtained edible composition was ingested, a composition having a high cosmetological effect was obtained.
＜製造例６〜製造例１０＞
下記表３の配合にて、松樹皮と、本発明の他素材を配合して、均一になるように混合し、ゼラチンを含む被膜に充填することによってハードカプセルを製造した（１粒あたり３５０ｍｇ）。得られた飲食用組成物を摂取したところ、美容効果の高い組成物が得られた。
<Manufacturing Example 6 to Manufacturing Example 10>
In the formulation shown in Table 3 below, pine bark and other materials of the present invention were blended, mixed so as to be uniform, and filled in a film containing gelatin to produce a hard capsule (350 mg per capsule). When the obtained edible composition was ingested, a composition having a high cosmetological effect was obtained.
＜製造例１１〜製造例１５＞
下記表４の配合にて、松樹皮と、本発明の他素材を配合して、均一になるように混合し、ゼラチン及びグリセリンを含む被膜で被包することによってソフトカプセルを製造した（１粒あたり３００ｍｇ）。得られた飲食用組成物を摂取したところ、美容効果の高い組成物が得られた。
<Manufacturing Examples 11 to 15>
Soft capsules were produced by blending pine bark and other materials of the present invention in the formulation shown in Table 4 below, mixing them uniformly, and encapsulating them with a film containing gelatin and glycerin (per capsule). 300 mg). When the obtained edible composition was ingested, a composition having a high cosmetological effect was obtained.
＜製造例１６〜製造例２０＞
下記表５の配合にて、松樹皮と、本発明の他素材を配合して、均一になるように混合することによって粉末飲料を製造した。得られた飲食用組成物３ｇを１５０ｍＬの水と混合し、飲用したところ、美容効果の高い組成物が得られた。
<Manufacturing Example 16 to 20>
A powdered beverage was produced by blending pine bark and other materials of the present invention in the formulation shown in Table 5 below and mixing them so as to be uniform. When 3 g of the obtained edible composition was mixed with 150 mL of water and drunk, a composition having a high cosmetic effect was obtained.
＜製造例２１〜製造例２５＞
下記表６の配合にて、松樹皮と、本発明の他素材を配合して型流動層造粒機に投入し、数分間気流で混合し、これに、水６０Ｌを１分間に２０００ｍＬ噴霧することにより造粒を行った。つづいて、得られた造粒物を３０メッシュの篩いにて篩別し顆粒を製造した。得られた飲食用組成物を摂取したところ、美容効果の高い組成物が得られた。
<Manufacturing Examples 21 to 25>
In the formulation shown in Table 6 below, pine bark and other materials of the present invention are mixed and put into a mold fluidized bed granulator, mixed with an air flow for several minutes, and 60 L of water is sprayed on this in 2000 mL per minute. Granulation was performed by this. Subsequently, the obtained granules were sieved with a 30-mesh sieve to produce granules. When the obtained edible composition was ingested, a composition having a high cosmetological effect was obtained.
＜製造例２６〜製造例３０＞
下記表７の配合にて、松樹皮と、本発明の他素材を配合し、ローションを製造した。得られた外用剤を使用したところ、美容効果の高い組成物が得られた。
<Manufacturing Example 26 to 30>
A lotion was produced by blending pine bark and other materials of the present invention with the blending shown in Table 7 below. When the obtained external preparation was used, a composition having a high cosmetic effect was obtained.
＜製造例３１〜製造例３５＞
下記表８の配合にて、松樹皮と、本発明の他素材をそれぞれ配合し、クリームを製造した。得られた外用剤を使用したところ、美容効果の高い組成物が得られた。
<Manufacturing Examples 31 to 35>
A cream was produced by blending pine bark and other materials of the present invention with the formulations shown in Table 8 below. When the obtained external preparation was used, a composition having a high cosmetic effect was obtained.
＜製造例３６〜製造例４０＞
下記表９の配合にて、松樹皮と、本発明の他素材をそれぞれ配合し、乳液を製造した。得られた外用剤を使用したところ、美容効果の高い組成物が得られた。
<Manufacturing Example 36-Manufacturing Example 40>
A milky lotion was produced by blending pine bark and other materials of the present invention with the formulations shown in Table 9 below. When the obtained external preparation was used, a composition having a high cosmetic effect was obtained.
＜製造例４１〜製造例４５＞
下記表１０の配合にて、松樹皮と、本発明の他素材をそれぞれ配合し、ゲル剤を製造した。得られた外用剤を使用したところ、美容効果の高い組成物が得られた。
<Manufacturing Examples 41 to 45>
A gel agent was produced by blending pine bark and other materials of the present invention with the blending shown in Table 10 below. When the obtained external preparation was used, a composition having a high cosmetic effect was obtained.
＜製造例４６〜製造例５０＞
下記表１１の配合にて、松樹皮と、本発明の他素材をそれぞれ配合し、エアゾール剤を製造した。得られた外用剤を使用したところ、美容効果の高い組成物が得られた。
<Manufacturing Example 46 to 50>
An aerosol agent was produced by blending pine bark and other materials of the present invention with the formulations shown in Table 11 below. When the obtained external preparation was used, a composition having a high cosmetic effect was obtained.
本発明の美容組成物は、健康食品等として用いることができることから、産業上の有用性は高い。
Since the beauty composition of the present invention can be used as a health food or the like, it is highly industrially useful.
Claims (3)
The cosmetological composition according to claim 1 or 2, characterized in that it is for oral use.
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| CN116173151A (en) * | 2023-04-21 | 2023-05-30 | 广东海洋大学 | Application of ceramide compound in antioxidation stress |
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