JP2020111560A - Treatment composition for restoring damaged hair using cystamine derivative - Google Patents
Treatment composition for restoring damaged hair using cystamine derivative Download PDFInfo
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- JP2020111560A JP2020111560A JP2019023530A JP2019023530A JP2020111560A JP 2020111560 A JP2020111560 A JP 2020111560A JP 2019023530 A JP2019023530 A JP 2019023530A JP 2019023530 A JP2019023530 A JP 2019023530A JP 2020111560 A JP2020111560 A JP 2020111560A
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- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical class CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 238000011282 treatment Methods 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 229940099500 cystamine Drugs 0.000 claims abstract description 27
- 230000006378 damage Effects 0.000 claims abstract description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 3
- 230000035876 healing Effects 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 15
- 238000004040 coloring Methods 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 8
- 238000004061 bleaching Methods 0.000 abstract description 7
- 229960003067 cystine Drugs 0.000 abstract description 7
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract description 5
- 239000000835 fiber Substances 0.000 abstract description 5
- 230000003796 beauty Effects 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- 108060008539 Transglutaminase Proteins 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 230000003700 hair damage Effects 0.000 description 3
- 102000003601 transglutaminase Human genes 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010044625 Trichorrhexis Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- -1 amino, amino Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000863 peptide conjugate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003141 primary amines Chemical group 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000003664 tensile strength of the hair Effects 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
本発明は、シスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物に関するものであって、更に詳細には、頻繁なカラーリング、ブリーチ及びパーマ施術に因り損傷した毛髪のシスチン結合物質を付与することで毛髪の損傷を防ぐことができ、毛髪の内部繊維組職を強化して健康な毛髪で回復させることができるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物に関するものである。 FIELD OF THE INVENTION The present invention relates to a treatment composition for repairing damaged hair using a cystamine derivative, and more particularly, it provides a cystine-binding substance for damaged hair due to frequent coloring, bleaching and perm treatment. Accordingly, the present invention relates to a treatment composition for recovering damaged hair using a cystamine derivative, which can prevent damage to the hair, strengthen the internal fiber structure of the hair and recover the healthy hair.
人類にとって健康と美を保つ事は、自分自身を満足させると同時に他人に自身を誇示する手段でもある。生活に余裕ができるにつれ、人々は健康になり美しくなる事に多くの努力と時間を惜しみなく投資し、文化水準が向上するにつれ、顔の化粧に劣らず頭髪や身体全般の美容も重要であると考えるようになって来た。 Maintaining good health and beauty is a way for humanity to both satisfy themselves and show off to others. As people can afford to live their lives, people will invest a lot of effort and time to become healthy and beautiful, and as the cultural standards improve, beauty of hair and body as much as facial makeup is important. I started to think.
しかし、このような美容への強い関心は、パーマ、ヘアードライヤー、カラーリング、マニキュアコーティング等の過剰な毛髪美容施術へとつながっており、これらに因る毛髪及び皮膚の物理的、化学的損傷などといった逆効果も引き起こしている。 However, such a strong interest in beauty has led to excessive hair beauty treatments such as perms, hair dryers, coloring, and manicure coating, resulting in physical and chemical damage to hair and skin. It also causes the opposite effect.
最近、ブリーチ、カラーリング、ホットパーマが流行するにつれ、損傷毛髪が急激に増えているが、このような毛髪はいったん損傷すると回復が不可能となる。市販されているヘアーエッセンス、ヘアートリートメントがあたかも損傷毛髪の回復を可能とするかのように宣伝されているが、シリコーン、界面活性剤を用いた製品であり、消費者が一時的に回復したかのように感じるに過ぎない。 With the recent spread of bleaching, coloring, and hot perms, the number of damaged hair has increased rapidly, but once damaged, it becomes impossible to recover. Although it is advertised that commercially available hair essences and hair treatments make it possible to recover damaged hair, it is a product that uses silicone and a surfactant, and whether the consumer has temporarily recovered. It just feels like.
また、シャンプーで洗髪する場合、頭皮と毛髪に自然に存在すべき栄養成分、皮脂成分、保湿成分等がすべて流されてしまいやすく、頭皮と毛髪が乾燥してパサつき、ひどくなると痒みを誘発するといった副作用を引き起こすことから、これを補う必要がある。 Also, when washing hair with shampoo, all nutrients, sebum, moisturizing ingredients, etc. that should be naturally present in the scalp and hair are easily washed away, and the scalp and hair become dry and dry, causing itching when it becomes severe. Since it causes side effects such as, it is necessary to compensate for this.
一般的に毛髪はケラチンというタンパク質から成り、その中においても具体的に毛髪は、１８種のアミノ酸のうち、システインを１４〜１８％含むケラチンタンパク質である。これらのケラチンタンパク質は、水または中性溶媒のような穏やかな条件下では非常に強いタンパク質の一種であるが、日常生活における、ブラッシング、ドライヤーの熱、カラーリング、パーマなどのような毛髪に対する物理的、化学的な処理に因り損傷しやすい。 Generally, hair is composed of a protein called keratin, and in particular, the hair is a keratin protein containing 14 to 18% of cysteine among 18 kinds of amino acids. These keratin proteins are a kind of very strong protein under mild conditions like water or neutral solvent, but in daily life, they have physical properties for hair such as brushing, dryer heat, coloring, perm, etc. It is easily damaged by physical and chemical treatment.
また、頻繁なパーマ、カラーリングなどの様々な物理的、化学的または環境的な要因により毛髪が損傷を受けると毛髪内部のタンパク質が溶出し、多孔質化することから、毛髪がパサつき、艶を失って柔らかさと柔軟効果が弱まり、摩擦力が増して扱いにくい毛髪となる。これらのことから、最近では、毛髪が切れやすくなり、または枝毛が発生するなどの問題とともに毛髪が細くなって弾力を失い、生気なく垂れさがることでボリューム感が消えてしまう問題が発生している。 Also, when hair is damaged by various physical, chemical or environmental factors such as frequent perms and coloring, proteins inside the hair elute and become porous, which makes the hair dry and glossy. Loses its softness and softening effect, increasing friction and making hair unmanageable. From these things, recently, with the problem that hair is easily cut or split ends occur, the hair becomes thin and loses elasticity, and there is a problem that the volume feeling disappears due to sagging without life. There is.
このような問題を解決すべく、洗浄時または洗浄後の毛髪の柔らかさを改善し、損傷した毛髪を回復または強化させるための毛髪用組成物に関する継続的な研究が行われて来た。その結果、強く、持続的な毛髪コンディショニング効果をもたらすための様々な方法が試みられ開発されている。 In order to solve such problems, continuous research has been conducted on hair compositions for improving the softness of hair during or after washing and for restoring or strengthening damaged hair. As a result, various methods have been tried and developed to provide a strong, lasting hair conditioning effect.
例えば、韓国公開特許第１０−２００７−００３８５０９号は、レチノイン酸のアミノ、アミノ酸またはペプチド結合体を含んで皮膚の老化にかかる現象を予防／治療する化粧剤を開示しているが、その効果は洗浄により著しく弱まるものであり、持続性に欠けるという短所がある。米国登録特許第５４９０９８０号には、毛髪、皮膚、爪などのような人体のタンパク質成分を構成するアミノ酸のうち、リシンとグルタミンの間のイソペプチド結合を形成するトランスグルタミナーゼを用いて毛髪、皮膚及び爪に有用なコンディショニング、抗菌、染料、香料等の様々な有効物質を伝達する手段として使用する方法が開示されており、日本特許公報第３５６７９１５号には、分子の中にリジン及び／またはグルタミン残基を含む分子量２０３以上のペプチド、トランスグルタミナーゼ及び特定化学式の１級アミン構造を有する化合物を含有する毛髪処理剤を開示している。 For example, Korean Patent Publication No. 10-2007-0038509 discloses a cosmetic agent containing an amino, amino acid or peptide conjugate of retinoic acid to prevent/treat a phenomenon related to skin aging. Since it is significantly weakened by washing, it has the disadvantage of lacking durability. U.S. Pat. No. 5,490,980 discloses that, among amino acids constituting protein components of the human body such as hair, skin, nails and the like, transglutaminase forming an isopeptide bond between lysine and glutamine is used for hair, skin and A method of using various active substances such as conditioning, antibacterial, dye, and fragrance useful for nails is disclosed, and Japanese Patent Publication No. 3567915 discloses lysine and/or glutamine residue in the molecule. Disclosed is a hair treatment agent containing a peptide having a molecular weight of 203 or more containing a group, transglutaminase, and a compound having a primary amine structure of a specific chemical formula.
しかし、前記発明において使用した酵素であるトランスグルタミナーゼは分子量が約３８ＫＤａ程度の巨大分子を有する酵素であって、毛髪の表面にはその適用を容易に成し得るものの、実質的には、構造強化が必要な毛髪内部の損傷部分には適用が難しいという短所があり、その効果は非常に限定的である。 However, transglutaminase, which is the enzyme used in the above-mentioned invention, is an enzyme having a macromolecule with a molecular weight of about 38 KDa, and although it can be easily applied to the surface of hair, it is substantially structurally strengthened. However, it is difficult to apply it to the damaged part inside the hair, which has a very limited effect.
したがって、物理的、化学的または環境的な様々な要因によって損傷を受けた毛髪を本来の健康な状態に回復させることのできる損傷毛髪回復のためのトリートメント組成物に関する研究が切に求められるところである。 Therefore, there is an urgent need for research on a treatment composition for repairing damaged hair, which can restore the hair damaged by various physical, chemical or environmental factors to the original healthy condition. ..
本発明は、頻繁なカラーリング、ブリーチ及びパーマ施術に因り損傷した毛髪のシスチン結合物質を付与することで毛髪の損傷を防ぐことができ、毛髪の内部繊維組職を強化して健康な毛髪で回復させることができるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物を提供することを目的とする。 INDUSTRIAL APPLICABILITY The present invention can prevent hair damage by applying a cystine-binding substance to hair damaged by frequent coloring, bleaching, and perm treatment, and strengthen internal fiber structure of hair to improve healthy hair. It is an object to provide a treatment composition for healing damaged hair using a cystamine derivative that can be restored.
本発明が解決しようとする様々な課題は、以上において言及した課題に制限されず、言及されていないまた他の課題は、以下の記載から当業者に明確に理解され得るであろう。 The various problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned above will be clearly understood by those skilled in the art from the following description.
本発明によるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物は、シスタミン誘導体を含む。 The treatment composition for repairing damaged hair using the cystamine derivative according to the present invention comprises the cystamine derivative.
前記シスタミン誘導体には、シスタミンジマレアート、シスタミンジカルボシステイネートまたはシスタミンジグルタメートの中から選択されたいずれか一つを使用することができる。 The cystamine derivative may be any one selected from cystamine dimaleate, cystamine dicarbocisteinate and cystamine diglutamate.
前記シスタミンジマレアートにはトリートメント組成物全体含量中に５ないし１５重量％が含まれており、シスタミンジカルボシステイネートには２５ないし３５重量％が、シスタミンジグルタメートには２５ないし３５重量％が含まれ得る。 The cystamine dimaleate comprises 5 to 15% by weight of the total treatment composition, 25 to 35% by weight of cystamine dicarbocysteinate and 25 to 35% by weight of cystamine diglutamate. Can be included.
前記シスタミン誘導体以外にポリクォータニウム−１０、水溶性シリコーン、フェノキシエタノール、香料及び精製水を更に含み得る。 In addition to the cystamine derivative, polyquaternium-10, water-soluble silicone, phenoxyethanol, fragrance and purified water may be further included.
その他の実施例の具体的な事項は、詳細な説明に含まれている。 Specific details of the other embodiments are included in the detailed description.
本発明によるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物は、頻繁なカラーリング、ブリーチ及びパーマ施術に因り損傷した毛髪のシスチン結合物質を付与することで毛髪の損傷を防ぐことができ、毛髪の内部繊維組職を強化して健康な毛髪で回復させることができる。 The treatment composition for repairing damaged hair using the cystamine derivative according to the present invention can prevent hair damage by applying a cystine-binding substance to hair damaged by frequent coloring, bleaching and perm treatment. , Can strengthen the internal fiber structure of hair and restore it with healthy hair.
本発明の技術的思想の実施例は、具体的に言及されていない様々な効果を提供し得ることが充分に理解され得るであろう。 It can be fully understood that the embodiments of the technical idea of the present invention can provide various effects not specifically mentioned.
本発明の利点及び特徴、そして、それらを達成する方法は、詳細に後述されている実施例を参照すれば明確になるであろう。しかし、本発明は、ここで説明される実施例に限定されるものではなく、他の形態として具体化されることもある。むしろ、ここで紹介される実施例は、開示された内容が徹底して完全なものとなるようにし、当業者に本発明の思想を充分に伝達するために提供されるものである。 The advantages and features of the present invention, and the manner of achieving them, will be apparent with reference to the examples described in detail below. However, the present invention is not limited to the embodiments described herein, and may be embodied in other forms. Rather, the embodiments presented herein are provided in order to ensure that the disclosed contents are thorough and complete, and to fully convey the concept of the invention to those skilled in the art.
本出願において使用した用語は、単に特定の実施例を説明するために使用されたものであって、本発明を限定しようとする意図ではない。単数の表現は文脈上明白に示さない限り、複数の表現を含む。 The terms used in this application are used merely to describe a particular embodiment and are not intended to limit the invention. A singular expression includes plural expressions unless the context clearly dictates otherwise.
特別に定義しない限り、技術的、科学的用語を含んでここで使用される全ての用語は本発明が属する技術分野で通常の知識を有する者によって一般的に理解されるのと同一の意味を有する。一般的に使用される辞書に定義されているような用語は、関連技術の文脈上有する意味と一致する意味を有するものと解釈されるべきであり、本出願において明白に定義しない限り、理想的、または過度に形式的な意味として解釈されない。 Unless defined otherwise, all terms used herein, including technical and scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Have. Terms such as those defined in commonly used dictionaries should be construed to have the meaning consistent with the meaning they have in the context of the relevant art, and unless explicitly defined in this application the ideal , Or is not overly formalized.
以下、添付された図面を参照して、本発明によるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物について詳細に説明する。 Hereinafter, a treatment composition for repairing damaged hair using a cystamine derivative according to the present invention will be described in detail with reference to the accompanying drawings.
本発明によるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物は、頻繁なカラーリング、ブリーチ及びパーマ施術に因り損傷した毛髪のシスチン結合物質を付与することで毛髪の損傷を防ぐことができ、毛髪の内部繊維組職を強化して健康な毛髪で回復させることができる。 The treatment composition for repairing damaged hair using the cystamine derivative according to the present invention can prevent hair damage by applying a cystine-binding substance to hair damaged by frequent coloring, bleaching and perm treatment. , Can strengthen the internal fiber structure of hair and restore it with healthy hair.
すなわち、一般的に頻繁なカラーリング、ブリーチ及びパーマ施術に因り毛髪のシスチン結合が切断されて毛髪が損傷し、損傷した毛髪にはチオール残基が増加するのであるが、本発明による損傷毛髪改善用組成物は、前記のように損傷した毛髪のシスチン結合を回復させることにより、損傷毛髪を復元することができる。 That is, the cystine bond of the hair is generally broken due to frequent coloring, bleaching, and perm treatment to damage the hair, and thiol residues increase in the damaged hair. The composition can restore damaged hair by restoring the cystine bond of damaged hair as described above.
本発明による損傷毛髪回復のためのトリートメント組成物はシスタミン誘導体を含む。 The treatment composition for repairing damaged hair according to the present invention comprises a cystamine derivative.
前記シスタミン誘導体には、シスタミンジマレアート、シスタミンジカルボシステイネートまたはシスタミンジグルタメートの中から選択されたいずれか一つを使用することができる。 The cystamine derivative may be any one selected from cystamine dimaleate, cystamine dicarbocisteinate and cystamine diglutamate.
また、本発明において、前記シスタミンジマレアートはトリートメント組成物全体含量中に５ないし１５重量％が含まれており、シスタミンジカルボシステイネートは２５ないし３５重量％が、シスタミンジグルタメートは２５ないし３５重量％が含まれ得る。 Further, in the present invention, the cystamine dimaleate is contained in an amount of 5 to 15% by weight in the total content of the treatment composition, cystamine dicarbocysteinate is 25 to 35% by weight, and cystamine diglutamate is 25 to 35% by weight. 35% by weight may be included.
１． シスタミンジマレアート 1. Cista Minji Maleto
（２） 性状：微黄色の結晶性粉末
（３） 構造式：下記の化学式２
(2) Property: Light yellow crystalline powder (3) Structural formula: Chemical formula 2 below
２． シスタミンジカルボシステイネート 2. Cystamine dicarbocysteinate
（２） 性状：微黄色または黄色の液体
（３） 構造式：下記の化学式４
(2) Property: Light yellow or yellow liquid (3) Structural formula: Chemical formula 4 below
３． シスタミンジグルタメート 3. Cystamine diglutamate
（２） 性状：微黄色または黄色の液体
（３） 構造式：下記の化学式６
(2) Property: Light yellow or yellow liquid (3) Structural formula: Chemical formula 6 below
以下、本発明によるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物に関する具体的な実験例をあげて更に詳細に説明する。 Hereinafter, the present invention will be described in more detail with reference to specific experimental examples of the treatment composition for recovering damaged hair using the cystamine derivative according to the present invention.
以下に示す成分組成表及び重量比に含まれるように損傷毛髪回復のためのトリートメント組成物を製造した。 A treatment composition for recovering damaged hair was prepared so as to be included in the composition table and weight ratio shown below.
１．実験例１ 1. Experimental example 1
２．実験例２ 2. Experimental example 2
３．実験例３ 3. Experimental example 3
４．実験方法
健康な毛髪に前記実験例１、２及び３の重量比率で配合されたトリートメント組成物を適量塗布して１０分間放置した後、微温水で洗浄してドライヤーで乾燥し、これを未処理毛髪と比較テストした。
4. Experimental method A suitable amount of the treatment composition blended in the weight ratio of Experimental Examples 1, 2 and 3 was applied to healthy hair, left for 10 minutes, washed with warm water and dried with a dryer, and then untreated. Tested against hair.
５．結果 5. result
前記結果において、サンプル毛髪は２日ごとにシャンプー後に観察した。 In the above results, the sample hair was observed every 2 days after shampooing.
前記結果を参照すると、未処理毛髪に比べ、シスタミン誘導体を添加した場合に損傷毛髪が回復したことが確認できた。 With reference to the above results, it was confirmed that the damaged hair was recovered when the cystamine derivative was added, as compared with the untreated hair.
また、シスタミンマレアートを添加した結果からは、損傷毛髪の切断したＳ−Ｓ−結合がマレイン酸の二重結合に反応して回復することが確認できる。 Also, from the result of adding cystamine maleate, it can be confirmed that the cut S—S— bond of damaged hair is recovered by reacting with the double bond of maleic acid.
図１は、本発明によるシスタミン誘導体を用いた損傷毛髪回復のためのトリートメント組成物が損傷毛髪を回復させる原理を簡略に説明するための図面である。 FIG. 1 is a diagram for briefly explaining the principle of the treatment composition for recovering damaged hair using the cystamine derivative according to the present invention to recover damaged hair.
図１を参照すると、本発明によるシスタミン誘導体は、シスタミンの−Ｓ−Ｓ−を更に一つ付与することで毛髪の弾性及び引張強度が増し、毛髪の豊かさを感じることができた。 Referring to FIG. 1, the cystamine derivative according to the present invention was able to increase the elasticity and tensile strength of the hair by adding one more —S—S— of cystamine, and to feel the richness of the hair.
また、シスタミンジカルボシステイネートとシスタミンジグルタメートはジペブチド類似物質であり、損傷毛髪のタンパク質残基と塩結合することから保湿、光沢に効果がある。 In addition, cystamine dicarbocysteinate and cystamine diglutamate are dipebutide-like substances and are effective in moisturizing and glossing because they form a salt bond with a protein residue of damaged hair.
一般的な損傷毛髪用の頭髪化粧品は、使用直後にシリコーン、界面活性剤等による一時的な効果があるだけでシャンプー後は直ちに洗い流されてしまうのであるが、本発明によるシスタミン誘導体を含むトリートメント組成物は、損傷した−Ｓ−Ｓ−結合の復元と補充されてから２〜３週程度、効果の維持が可能であった。 Generally, hair cosmetics for damaged hair have a temporary effect of silicone, a surfactant, etc. immediately after use and are immediately washed off after shampooing, but a treatment composition containing the cystamine derivative according to the present invention. The substance was able to maintain the effect for about 2-3 weeks after the restoration of the damaged -SS- bond and the supplementation.
以上、本発明の好ましい一実施例を説明したが、本発明が属する技術分野において通常の知識を持った者であるなら、本発明がその技術的思想や必須的特徴を変更することなく、別の具体的な形態として実施することができることを理解するであろう。それ故、以上において記述した一実施例は、すべての面において例示的なことであり、限定的ではないものとして理解すべきである。 The preferred embodiment of the present invention has been described above. However, if the person has ordinary knowledge in the technical field to which the present invention belongs, the present invention is not limited to the technical idea and the essential characteristics of the present invention. It will be understood that it can be implemented as a concrete form of. Therefore, the one embodiment described above should be understood as being illustrative in all aspects and not limiting.
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