JP2020007305A - Skin cleansing liquid composition - Google Patents

Abstract

To provide a skin cleansing liquid composition used by a method different from a conventional one.SOLUTION: There is provided a skin cleansing liquid composition, which comprises (A) a surfactant and (B) an amphiphatic ester and is stored in a spray type container, can exhibit excellent detergency while reducing skin irritation of a skin cleansing liquid composition and can provide a new application of directly spraying and applying a skin cleansing liquid composition to the skin which is different from the conventional usage for foaming in advance in applying to the skin.SELECTED DRAWING: None

Description

  The present invention relates to a skin cleansing liquid composition that can be cleaned without applying physical friction to the skin.

  Various skin cleansing compositions such as facial cleansers, body soaps, and shampoos have been provided as products intended to clean the skin and keep the skin clean. In the mechanism in which the skin cleansing composition cleans the skin, the surfactant adsorbs on the dirt to reduce the surface tension between the dirt and the water, and the dirt floats in the water in combination with the mechanical force due to friction. In order for such a washing mechanism to work effectively, it is necessary to mix a surfactant at a critical micelle concentration or higher.

  On the other hand, there is also a current situation in which the detergency of a surfactant is too strong, causing skin irritation, and as a result, skin problems such as dry skin are caused. For this reason, for the purpose of making the action on the skin mild, various prescriptions have been proposed to devise the combination and amount of the cleaning components. Above all, since foams formed during washing are recognized to reduce friction generated by direct contact between the skin and finger, formulas that improve foam quality such as bubble power and foam holding power are applied to the skin. It is common general knowledge that it is an excellent prescription for mild action.

  For this reason, in recent years, various pump-former type skin cleansing agents have been proposed, and attention has been paid to not only the convenience of easily obtaining high-quality foam but also the gentleness on the skin. Specifically, Patent Document 1 discloses a liquid skin cleansing product comprising a former container and a liquid skin cleanser composition filled in the former container, wherein the liquid skin cleanser composition comprises ( A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group having 7 to 21 carbon atoms, and (B) a specific dimethyldiallylammonium chloride and acrylic acid and / or acrylamide. And a (C) sugar alcohol, wherein the mass ratio (A) / (B) of the content of the component (A) to the content of the component (B) is from 20 to 250. A cleaning product is disclosed. Patent Document 2 discloses that (a) 2 to 9% by mass of a fatty acid salt, (b) 0.5 to 4% by mass of betaine lauryldimethylaminoacetate, and (c) one or more kinds of dihydric alcohols And the sum (a) + (b) of the compounding amounts (% by mass) of the components (a) and (b) is 3 to 10% by mass, and the compounding ratio (b) A skin cleanser composition characterized by filling a former container with a cleanser having / (a) of 0.1 to 0.5 is disclosed. Further, Patent Document 3 discloses a former container containing (a) betaine lauryldimethylaminoacetate and (b) 4 to 15% by mass of a higher fatty acid soap formed of a fatty acid having 5 to 25 carbon atoms and having a specific composition. Discloses a cleaning composition which is discharged in the following manner.

WO 2014/003114 JP-A-2006-098182 International Publication No. WO 2017/081897

The pump former type skin cleansing composition has a relatively small amount of a surfactant, and in that respect, irritation to the skin is reduced as compared with a solid or semi-solid skin cleansing composition. It seems that there is a tendency. On the other hand, since the pump-former type skin cleansing composition is premised on being discharged in the form of foam, the minimum surfactant necessary for exerting the foaming power is blended. This is inevitable in its configuration.

  In recent years, there has been an increasing awareness of cleansing the skin. At the same time, attention has also been paid to time-saving skin care, and a skin cleanser that is gentle on sensitive skin and that can be quickly cleaned is expected.

  Various skin cleansing agents have been created to remove body fluids such as sebum and sweat, and dirt, etc., excluding skin cleansing agents for the purpose of cleansing. It is presumed that whipping before application to the skin is premised, and that whipping well before washing is preferable in terms of reducing friction to the skin. Foam can reduce physical friction by intervening between the skin and hands, but because the foam itself rubs against the skin, it creates physical friction itself and stimulates the skin Is still there. In particular, in a beauty salon or a beauty salon, a cleaning treatment of the face or the like may be performed, and a cleaning treatment that is gentler to the skin is desired in order to improve the quality of service.

  Therefore, an object of the present invention is to provide a skin cleaning liquid composition that can be cleaned without applying physical friction to the skin.

  The present inventor, in order to further reduce the irritation to the skin, without applying foam to the skin beforehand, apply the liquid composition for skin cleansing directly to the skin, wash without applying physical friction to the skin This led to the idea of a novel use. Furthermore, they have found that the coexistence of an amphipathic ester with a surfactant can effectively provide detergency without applying physical friction to the skin. The present invention has been completed by further study based on this finding.

That is, the present invention provides the following aspects of the invention.
Item 1. A skin cleansing liquid composition comprising (A) a surfactant and (B) an amphipathic ester and used for cleaning without giving physical friction to the skin.
Item 2. Item 2. The skin cleansing liquid composition according to Item 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and (eicosane diacid / tetradecane diacid) polyglyceryl-10.
Item 3. Item 3. The skin cleansing liquid composition according to Item 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
Item 4. Item 4. The liquid composition for cleaning skin according to any one of Items 1 to 3, wherein the content of the component (A) is 0.025 to 2% by weight.
Item 5. Item 5. The liquid composition for cleaning skin according to Item 4, wherein the content of the component (A) is 0.025 to 0.9% by weight.
Item 6. A skin cleansing method comprising applying a skin cleansing liquid composition containing (A) a surfactant and (B) an amphiphilic ester to the skin without imparting physical friction to the skin.

  According to the liquid composition for skin cleansing of the present invention, it is possible to exert excellent detergency while reducing skin irritation, thus giving physical friction to the skin without foaming before application to the skin. Cleaning is possible. Since the washing can be performed without giving physical friction to the skin, the amount of the surfactant in the skin cleaning liquid composition is significantly reduced from that in the conventional skin cleaning liquid composition. This can further reduce skin irritation.

1. Liquid composition for skin cleansing The liquid composition for skin cleansing of the present invention comprises (A) a surfactant (hereinafter sometimes referred to as a component (A)) and (B) an amphiphilic ester (hereinafter referred to as (B) ) Component). Hereinafter, the skin cleansing liquid composition of the present invention will be described in detail.

(A) Surfactant The liquid composition for skin cleansing of the present invention contains a surfactant as the component (A). The surfactant is not particularly limited, but preferably includes an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, and a natural surfactant from the viewpoint of suppressing irritation to the skin. As the surfactant, one of anionic surfactants, nonionic surfactants, amphoteric surfactants, and natural surfactants may be used alone, or two or more surfactants may be arbitrarily combined. May be used.

  Examples of the anionic surfactant used in the present invention include carboxylic acid type, sulfonic acid type, sulfate ester type and phosphate ester type surfactants.

  Specific examples of the carboxylic acid type surfactant include saturated or unsaturated fatty acids having 6 to 22 carbon atoms such as octanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, and stearic acid; octanoyl group, decanoyl N-acylamino acids (carboxylic acid-type amino acid-based anionic surfactants) having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as a group, lauroyl group, myristoyl group, palmitoyl group, cocoyl group and the like. Can be Examples of the N-acyl amino acid in the carboxylic acid type amino acid anionic surfactant include N-acyl sarcosine, N-acyl aspartic acid, N-acyl glutamic acid, lauroylmethyl-β-alanine and the like. More specific carboxylic acid-type amino acid-based anionic surfactants include N-lauroylsarcosine, N-lauroylaspartic acid, cocoylglutamic acid, sodium lauroylmethyl-β-alanine, and the like.

  Specific examples of the sulfonic acid type surfactant include esters of fatty acids having 6 to 22 carbon atoms such as cocoyl isethionic acid and isethionic acid; hexanesulfonic acid, octanesulfonic acid, decanesulfonic acid, dodecanesulfonic acid and the like. Alkyl sulfonic acid having 6 to 22 carbon atoms such as alkyl benzene sulfonic acid; alkyl benzene sulfonic acid having an alkyl group having 10 to 16 carbon atoms such as octanoyl group, decanoyl group, lauroyl group, myristoyl group, palmitoyl group, cocoyl group, etc. N-acyl-N-methyltaurine having a saturated or unsaturated N-acyl group of Formulas 8 to 24 (sulfonic acid type amino acid-based anionic surfactant). More specific sulfonic acid type amino acid anionic surfactants include N-myristoyl-N-methyltaurine, N-lauroylmethyltaurine, cocoylmethyltaurine and the like.

  Specific examples of the sulfate ester type surfactant include esters of a saturated or unsaturated fatty acid having 10 to 22 carbon atoms, such as lauryl sulfate and myristyl sulfate, with sulfuric acid. Specific examples of the phosphoric acid ester type surfactant include esters of phosphoric acid with a saturated or unsaturated fatty acid having 8 to 24 carbon atoms such as lauryl phosphoric acid.

  These anionic surfactants may be in the form of a salt, for example, an alkali metal salt such as a sodium salt or a potassium salt; a triethanolamine (TEA) salt; an ammonium salt or the like. it can.

  Among these anionic surfactants, from the viewpoint of better obtaining skin irritation reduction and detergency, preferably carboxylic acid type surfactants and sulfonic acid type surfactants, more preferably, Lauric acid, N-lauroyl aspartic acid, cocoyl glutamic acid, cocoyl methyl taurine and salts thereof, more preferably, sodium laurate, sodium N-lauroyl aspartate, cocoyl glutamate triethanolamine, cocoyl methyl taurine sodium. Can be Further, among these, from the viewpoint of further improving skin irritation reduction, preferably N-acylglutamic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms and fatty acid amide sulfonic acid having 8 to 22 carbon atoms, These salts include, more preferably, cocoyl glutamic acid, cocoyl methyl taurine and salts thereof, further preferably, cocoyl glutamic acid triethanolamine, cocoyl methyl taurine sodium, and furthermore, the detergency is more preferably obtained. From the viewpoint, preferably, N-acyl aspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms is used, more preferably, N-lauroyl aspartic acid is used, and even more preferably, sodium N-lauroyl aspartate is used. Is mentioned.

  These anionic surfactants may be used alone or in a combination of two or more.

  Examples of the nonionic surfactant used in the present invention include surfactants of ester type, ether type, ester ether type, alkanolamide type, alkyl glycoside type, alcohol type and the like.

  Specific examples of the ester type surfactant include those having 8 to 20 carbon atoms such as glycol dilaurate, glycol monostearate, glycol distearate, glyceryl monolaurate, glyceryl dilaurate, glyceryl monostearate, and glyceryl distearate. Mono- or diesters of glycerin with saturated or unsaturated fatty acids; sorbitan fatty acid esters; sucrose fatty acid esters.

  Specific examples of the ether type surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene glycol, and the like.

  Examples of the ester / ether type surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitan fatty acid ester, and sorbitan fatty acid ester polyethylene glycol.

  Specific examples of the alkanolamide-type surfactant include cocamide DEA (coconut oil fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, and stearic acid diethanolamide.

  Specific examples of the alkyl glycoside surfactant include octyl glucoside, decyl glucoside, lauryl glucoside, and the like.

  Examples of the alcohol type surfactant include cetanol, stearyl alcohol, oleyl alcohol and the like.

  Among these nonionic surfactants, from the viewpoint of obtaining better skin irritation reduction and detergency, preferably ester-ether type surfactants and alkanolamide type surfactants, Preferably, polyoxyethylene hydrogenated castor oil and cocamide DEA are used, and more preferably, polyoxyethylene hydrogenated castor oil is used.

These nonionic surfactants may be used alone or in a combination of two or more.

  Examples of the amphoteric surfactant used in the present invention include surfactants of alkyl betaine type, fatty acid amide propyl betaine type, amine oxide type and the like.

  Specific examples of the alkylbetaine type surfactant include betaine lauryl dimethylaminoacetate, betaine stearyl dimethylaminoacetate, and octadecylaminomethyldimethylsulfopropyl betaine.

  Specific examples of the fatty acid amidopropyl betaine-type amphoteric surfactant include amidobetaine (amino acid-based amphoteric surfactant) such as cocamidopropyl betaine and sulfobetaine such as cocamidopropylhydroxysultaine.

  Specific examples of the amine oxide type amphoteric surfactant include lauryl dimethylamine N-oxide, oleyldimethylamine N-oxide and the like.

  These amphoteric surfactants may be in the form of a salt, for example, an alkali metal salt such as a sodium salt or a potassium salt; a triethanolamine (TEA) salt; an ammonium salt or the like. .

  Among these amphoteric surfactants, fatty acid amide propyl betaine-type surfactants are preferred from the viewpoint of better skin irritation reduction and detergency, and amide betaines such as cocamidopropyl betaine are more preferred. Amino acid-based amphoteric surfactant), and more preferably cocamidopropyl betaine.

  These amphoteric surfactants may be used alone or in a combination of two or more.

  Examples of the natural surfactants used in the present invention include lecithin and lysolecithin; saponins such as quillaja saponin, soybean saponin, yucca saponin, endusa saponin, beet saponin, azusaponin, carrot saponin, tea seed saponin, hemima saponin, tsukusa saponin and the like. And the like.

  Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol, and components such as triglycerides, fatty acids, and carbohydrates from vegetable oils. is there.

  The lecithin may be natural lecithin derived from animals and plants (for example, soybean lecithin, egg yolk lecithin, etc.) itself, a chemically treated natural lecithin, or a purified natural lecithin. . Examples of the chemically treated natural lecithin include hydrogenated lecithin obtained by hydrogenation treatment (for example, completely hydrogenated lecithin and partially hydrogenated lecithin), and hydroxylated lecithin obtained by hydroxylation treatment. Examples of the purified natural lecithin include lecithin in which the content of phosphatidylcholine is increased by a solvent such as acetone.

  Examples of lysolecithin include lyso-forms of the above-mentioned lecithin (natural lecithin, a chemically-treated natural lecithin, and a purified natural lecithin). Lysolecithin has a structure in which the fatty acid at position 2 of phosphatidylcholine has been removed by hydrolyzing (dissolving) lecithin with an enzyme such as phospholipase A2.

  Among these natural surfactants, preferably lecithin, lysolecithin and saponin are mentioned from the viewpoint of better skin irritation reduction and detergency, more preferably lecithin and lysolecithin, and even more preferably lysolecithin. No.

  These natural surfactants may be used alone or in a combination of two or more.

  The content of the component (A) in the skin cleanser liquid composition of the present invention is not particularly limited, and can be appropriately determined according to the detergency to be provided. Since the skin cleansing liquid composition of the present invention can be washed without giving physical friction to the skin, the amount of the surfactant in the skin cleansing liquid composition can be reduced by the conventional skin cleansing liquid. It can be significantly reduced than the amount contained in the composition, and it can effectively exert detergency even with a small amount of surfactant such that it cannot inherently exhibit effective detergency it can. From such a viewpoint, the content of the component (A) in the skin cleanser liquid composition of the present invention is preferably 0.025 to 2% by weight, more preferably 0.025 to 1.5% by weight or less, More preferably, the content is 0.025 to 1% by weight or less, particularly preferably 0.025 to 0.9% by weight or less. Since the amount of the surfactant is small as described above, skin irritation can be further reduced. From the viewpoint of obtaining more excellent detergency, the lower limit of the content of the component (A) is preferably 0.1% by weight or more, and more preferably 0.5% by weight or more. More preferred.

(B) Amphipathic ester The liquid composition for skin cleansing of the present invention contains an amphipathic ester as the component (B). The component (B) alone does not exhibit a detergency, but the coexistence with the component (A) can improve the detergency of the liquid composition for skin cleansing while maintaining low irritation.

  In the present invention, the amphiphilic ester is dissolved in ion-exchanged water adjusted to have a conductivity of 70 to 110 μs / m at room temperature in an amount of 2% by mass or more, as measured by the method specified in the Japanese Pharmacopoeia General Test Method, and It is also soluble in isotridecyl isononanoate (Salacos 913, manufactured by Nisshin Oillio Group) at room temperature (25 ° C.) in an amount of 10% by mass or more, and excludes ester surfactants.

  The amphiphilic ester is not particularly limited, but from the viewpoint of better skin irritation reduction and detergency, bis (polyoxyalkylene alkyl ether) dicarboxylate and (eicosane diacid / tetradecane diacid) polyglyceryl-10 are preferred. It is preferably selected from the group consisting of: As the amphiphilic ester, any one of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and (eicosane diacid / tetradecane diacid) polyglyceryl-10 may be used alone, or both may be used in combination. May be used. Among these amphiphilic esters, bis (polyoxyalkylene alkyl ether) ester dicarboxylates are more preferable from the viewpoint of better skin irritation reduction and detergency.

The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include, for example, oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemelic acid, Examples include suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid, and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include, for example, polyoxyethylene monoalkyl ether, and more specifically, for example, diethylene glycol monoethyl ether, triethylene glycol monoethyl ether, and the like. Can be

  Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, from the viewpoint of better skin irritation reduction and detergency, preferably a diester of cyclohexane-1,4-dicarboxylic acid and diethylene glycol monoethyl ether. Compounds, specifically, INCI names (International Cosmetic Ingredient Dictionary and Handbook, 13th Edition, Volume 1, CTFA, 2010, p. 331): BIS-ETHOXYDIGLYCOL CYCLOHEXANE, 4-DIALBOARD Hexane-1,4-dicarboxylic acid compound called bisethoxydiglycol, succinic acid and diethylene glycol monoethyl ether Diester compound, specifically, INCI (International Cosmetic Ingredient Dictionary and Handbook, 13th edition, Volume 1, CTFA, 2010, p. 331-332): BIS-ETHOXYDIGLYCOL SUCCINATE A compound referred to as bisethoxydiglycolic acid is more preferred, and bisethoxydiglycol cyclohexane-1,4-dicarboxylate is more preferred.

In the present invention, specific examples of the bisethoxydiglycol cyclohexane-1,4-dicarboxylate include "Neosolue-Aqulio (trade name)" manufactured by Nippon Seika Co., Ltd. Specific examples of the bisethoxydiglycol succinate include, for example, "HIAQOSTER DCS (trade name)" manufactured by Higher Alcohol Industry Co., Ltd.

  These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used alone or in a combination of two or more.

  Polyglyceryl-10 (eicosane diacid / tetradecane diacid) used in the present invention is not particularly limited. For example, "Neosolue-Aqua (trade name)" or "Neosolue-AquaS (trade name)" manufactured by Nippon Seika Co., Ltd. (Product name) ”and the like.

  The content of the component (B) in the liquid composition for skin cleansing of the present invention is not particularly limited, but examples include 0.1% by weight or more. From the viewpoint of obtaining better detergency, the content of the component (B) is preferably 0.5% by weight or more. Although the upper limit of the range of the content of the component (B) is not particularly limited, for example, 5% by weight or less, preferably 3% by weight or less, and more preferably 2% by weight from the viewpoint of the stability of the liquid composition for skin cleansing. The following are mentioned.

  In the liquid composition for skin cleansing of the present invention, the ratio of the component (A) to the component (B) is not particularly limited and is determined by the above contents, but the skin irritation reducing property and the detergency are more preferably obtained. From the viewpoint, the component (B) is, for example, 0.1 to 100 parts by weight, preferably 0.1 to 10 parts by weight, more preferably 0.5 to 5 parts by weight with respect to 1 part by weight of the component (A). .

Other Ingredients The liquid composition for cleansing skin of the present invention contains, in addition to the aforementioned components, other bases and additives required for formulation and the like within a range not to impair the effects of the present invention. You may. Such additives are not particularly limited as long as they are pharmaceutically acceptable. For example, water, lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, etc.), and polyhydric alcohols (ethylene glycol, Aqueous bases such as 1,3-butylene glycol (1,3-BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin and the like; preservatives (methylparaben, propylparaben, benzoic acid, benzoic acid) Sodium acid, sorbic acid, etc.), flavoring agents (citral, 1,8-ionel, citronellal, farnesol, etc.), coloring agents (tar dyes (brown 201, blue 201, yellow 4, yellow 403, etc.)), Cocoa pigment, chlorophyll, aluminum oxide Etc.), thickeners (hydroxypropylcellulose, hydroxyethylcellulose, crosslinked acrylic acid polymer, carboxyvinyl polymer, hypromellose, polyvinylpyrrolidone, sodium alginate, ethylcellulose, sodium carboxymethylcellulose, xanthan gum, carrageenan, etc.), pH adjuster (phosphorus) Acid, hydrochloric acid, citric acid, sodium citrate, succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), wetting agent (dl-pyrrolidone carboxylate sodium solution, D-sorbitol solution, Macrogol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-aspartic acid, L-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, ultraviolet absorbers, chelating agents, adhesives, buffers, dissolving Additives such as auxiliaries, solubilizers, preservatives and the like can be mentioned. These base materials and additives may be used alone or in a combination of two or more. The content of these base materials and additives can be appropriately set according to the formulation form and the like.

  The liquid composition for skin cleansing of the present invention may contain other pharmacological components, if necessary, in addition to the above components, as long as the effects of the present invention are not impaired. Examples of such pharmacological components include vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, niacin , Folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, proparacaine, mepricaine or salts thereof, orthocaine, oxesazein, oxypolyoxygen Decane, funnel extract, percaminepase, tesit decithin, etc., anti-inflammatory agents (indomethacin, felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protective agents (collodion, castor oil) ), Blood circulation promoting components (nonylate varnishylamide, nicotinic acid benzyl ester, capsaicin, pepper extract, etc.), fresheners (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (sodium chondroitin sulfate, glucosamine, etc.) ) And the like. These pharmacological components may be used alone or in a combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of the pharmacological components used, the expected effects, and the like.

Form The form of the liquid composition for cleaning skin of the present invention is liquid or gel at room temperature. Further, the viscosity of the liquid composition for skin cleansing of the present invention at 20 ° C. is 10,000 mPa · s or less, preferably 5000 mPa · s or less. The viscosity is a value measured by a BL viscometer (Rotor No. 3, 6 rpm, 20 ° C.).

Container The container containing the liquid composition for cleaning skin of the present invention is not particularly limited as long as the liquid composition for cleaning skin can be directly applied to the skin from inside the container. And a dropping or dropping type container (especially a washing bottle). From the viewpoint of ease of treatment in a beauty salon or a beauty salon, preferably a pouring or dropping type container (especially a washing bottle). The spray-type container of the present invention discharges the contents in a mist state, and is different from a pump former container which discharges the skin-cleaning liquid composition in a foam state.

  In the present invention, the skin cleansing liquid composition is contained in a spray-type container, a pouring or dropping type container (particularly, a cleaning bottle), and thus is not lathered before application to the skin. The liquid composition is applied directly to the skin. Therefore, application to the skin is easy, and physical friction due to hands or the like during application and / or physical friction due to foam during washing can be avoided. The spray type container includes a pump type spray container which is a non-aerosol type spray container, and an aerosol type spray container. The diameter (nozzle inner diameter) of the spray-type container is, for example, 0.01 to 3 mmφ, preferably 0.1 to 1 mmφ. When the spray container is a pump spray container, the injection amount per push is, for example, 0.05 to 1.2 g, preferably 0.1 to 0.3 g.

Uses The skin cleansing liquid composition of the present invention is used for removing body fluids such as fats and oils and sweat, dirt, and the like, and is not used for removing makeup (cleansing). The liquid composition for skin cleansing of the present invention is used for facial cleansing in beauty salons and beauty salons. The skin cleansing liquid composition of the present invention is used by applying it to the skin without diluting with water and without foaming. The amount used at one time depends on the concentration of the surfactant, the degree of dirt, and the like, but for example, 0.5 to 3 g, preferably 1 to 2 g when used for face washing.

  More specifically, the skin cleaning liquid composition can be directly applied to a site to be cleaned from a spray-type container, a pouring or dropping-type container (particularly, a cleaning bottle) without picking up the liquid composition. As described above, by directly applying the skin cleaning liquid composition to the site to be cleaned, friction between the skin of the site to be cleaned and the hand, friction between the skin of the site to be cleaned, and air bubbles, etc. Without applying any physical friction, cleaning can be performed only by utilizing the mechanical force of the liquid stream. Since the skin cleansing liquid composition of the present invention is a formulation having an excellent detergency, by using the mechanical force of the liquid flow without imparting physical friction in this way, it is applied to the skin during cleaning. Is remarkably reduced, and a very gentle cleaning method becomes possible. Such a non-foaming cleaning method enables quick cleaning, and makes it easy to realize that the amount of surfactant is low and that it is gentle on the skin, and that the consumer who is highly conscious of pursuing skin-friendly cleaning is easily satisfied.

  The site to be washed with the liquid composition for cleaning skin of the present invention is not particularly limited because it can wash any body part, and includes, for example, hands, hair, scalp, body, face and the like. Further, the skin cleansing liquid composition of the present invention can exhibit excellent cleansing power without giving physical friction to the skin, and thus is suitable for use on a face that is sensitive to irritation.

  After washing, the skin cleansing liquid composition can be washed away with water. When washing away with water, the washing is performed using the mechanical force of the water stream so as not to give physical friction by hand. The water used for rinsing is also contained in a spray container, a pouring or dripping container (especially a washing bottle), preferably a pouring or dripping container (especially a washing bottle), and is to be cleaned in the same manner as the skin cleaning liquid composition. Can be applied to the site.

  In addition, the skin cleaning liquid composition of the present invention can extremely reduce the surfactant concentration, and in this case, does not have to be washed off after washing. For this reason, the liquid composition for skin cleansing of the present invention is also suitable for wiping use in hospitals, skin cleansing applications such as face washing in beauty salons and beauty salons, and disaster product use. In the case of not rinsing, the liquid composition for skin cleaning remaining at the cleaning site may be removed by suction so as not to rub with a water-absorbing substrate such as a towel or tissue.

Manufacturing Method The liquid composition for skin cleansing of the present invention is prepared by mixing the above-mentioned components (A) and (B), and other components to be blended as required, and preparing the mixture into a predetermined form. Manufactured.

2. Skin Cleansing Method As described above, amphiphilic esters can improve the cleansing power of a skin cleansing composition containing a surfactant without imparting physical friction to the skin. Therefore, the present invention further provides a skin cleansing liquid composition containing the (B) component amphiphilic ester together with the (A) component surfactant, without giving physical friction to the skin. A skin cleaning method comprising applying to the skin. The skin cleaning method of the present invention can be carried out as a cleaning treatment performed in a beauty salon or a beauty salon.

  In the skin cleansing method, the types and amounts of the components used, the form of the skin cleanser composition, and the like are as shown in the above-mentioned “1. Liquid composition for skin cleansing”.

  Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited thereto.

Skin cleaning liquid compositions having the compositions shown in Tables 1 to 4 were prepared. Details of each component shown in Tables 1 to 4 are as follows. The skin cleansing liquid compositions shown in Tables 1 to 4 are liquid, and all of the viscosities at 20 ° C (measured with a BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm). It was in the range of 5000 mPa · s or less.
・ Sodium laurate (“NON-SAL LN-1” (trade name) manufactured by NOF CORPORATION)
・ Cocoyl glutamate TEA (“Amisoft CT-12S (brand name)” manufactured by Ajinomoto Co., Inc.)
・ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF Corporation)
・ Sodium N-lauroyl aspartate solution (20% by weight) (“Aminoformer FLDS-L (brand name)” manufactured by Asahi Kasei Fine Chemical Co., Ltd.)
・ Polyoxyethylene lauryl ether acetic acid (Kaohakipo RLM-45 (trade name) manufactured by Kao Corporation)
-Cocamide DEA ("Amizole CDE-G (trade name)" manufactured by Kawaken Fine Chemical Co., Ltd.)
-PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; NIKKOL HCO-60 (trade name) manufactured by Nikko Chemicals Co., Ltd.)
・ Polyoxyethylene sorbitan monostearate (Reodol TW-S120V manufactured by Kao Corporation)
-Glycerin mono-2-ethylhexyl ether ("Sensiva" manufactured by SEPPIC)
SC 50 JP (brand name) ")
・ Cocamidopropyl betaine (“Softazoline CPB (trade name)” manufactured by Kawaken Fine Chemical Co., Ltd.)
・ Lauryl hydroxysulfobetaine solution (30% by weight) (“Amphitol 20HD (trade name)” manufactured by Kao Corporation)
・ Lyso-lecithin (“Lyso-lecithin Kyowa (brand name)” manufactured by Kyowa Hakko Bio Co., Ltd.)
・ Kiraya extract (“Kiraya extract BG” manufactured by Maruzen Pharmaceutical Co., Ltd., saponin content 5% by weight)
-Bisethoxydiglycol cyclohexane-1,4-dicarboxylate ("Neosolue-Aqulio (trade name)" manufactured by Nippon Seika Co., Ltd.)
・ Bisethoxydiglycol succinate (“HIAQOSTER DCS (trade name)” manufactured by Higher Alcohol Industry Co., Ltd.)

<Evaluation of detergency>
About the prepared skin cleaning liquid composition, 10 panelists specializing in cosmetics evaluation evaluated the detergency. Specifically, each of the liquid compositions for cleaning skin is contained in a pump type spray container (“Z-155-C110 (trade name)” manufactured by Takemoto Container Co., Ltd., the injection amount per push is 0.15 g), and 0.5 g was applied by spraying directly on the face. It was left for about 5 seconds, and then washed with water so that the hands did not touch the face. After the face was suppressed with a towel and water was absorbed, the feeling of dirt on the skin was evaluated by sensory evaluation based on the following indices.

5 points: Dirt was felt firmly 4 points: Dirt was felt 3 points: Neither 2 points: Dirt was not felt much 1 point: Dirt was not felt at all

The obtained scores of 10 panelists were totaled, and the degree of detergency was evaluated according to the following classification. The results are shown in Tables 1 to 4.
◎: 45 points or more
：: 40 or more and less than 45
△: 35 points or more and less than 40 points
×: less than 35 points

<Tightness evaluation (Sensory evaluation of skin irritation)>
The prepared skin cleansing liquid composition was evaluated by ten panelists specializing in cosmetics evaluation. Specifically, each skin cleansing liquid composition is contained in a pump type spray container ("Z-155-C110 (trade name)" manufactured by Takemoto Container Co., Ltd. (the injection amount per push is 0.15 g), 1.5 g was applied by spraying directly on the face, left for about 5 seconds, and then rinsed with water so that hands would not touch the face. The feeling was scored by sensory evaluation based on the following indices.

5 points: No feeling of tightness at all 4 points: Little feeling of feeling of tightness 3 points: Feel only a little feeling of tightness 2 points: Feeling of feeling of tightness 1 point: Strong feeling of feeling of tightness

The acquired scores of the ten panelists were totaled, and the degree of tightness was evaluated by the following classification. The results are shown in Tables 3 and 4.
◎: 45 points or more
：: 40 or more and less than 45
△: 35 points or more and less than 40 points
×: less than 35 points

<Culture epidermis skin irritation test (in vitro evaluation of skin irritation)>
The prepared skin cleansing liquid composition was subjected to a cultured epidermal skin irritation test as follows.
1. Preparation of Culture Epidermal Model LabCyte EPI-MODEL24 The assay medium was warmed and added in 0.5 mL portions to a 24-well assay plate. The cultured epidermis model LabCyte EPI-MODEL24 (Lot No .: LCE24-180226-A) was transferred to a 24-well assay plate to which assay medium was added. After confirming that there were no bubbles on the bottom of the culture cup, the culture cup was placed in a CO ₂ incubator and allowed to stand for 1 hour or more until exposure to the test substance.

2. Application and washing of test substance Out of 24 epidermal models, 12 were used (the rest continued preculture until this test). The 24-well assay plates were removed from the CO ₂ incubator. The assay medium was warmed and added to the third row of the 24-well assay plate in 1.0 mL portions. A test substance (each skin cleaning liquid composition) was dropped to the culture epidermis of the culture cup without using a pump-type spray container, and 25 μL of the substance was exposed to the whole. At 1, 5 and 10 minutes after the exposure, the test substance was aspirated off, and the cultured epidermis model in the cup was washed with phosphate buffer (PBS) and transferred to the third row of a 24-well assay plate.

3. MTT test The MTT test is produced by reducing MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide] taken up into cells by mitochondrial dehydrogenase in the cells. This is a method of measuring the viable cell rate by extracting a formazan dye with an organic solvent and measuring the absorbance at 570 nm.

  10 mL of MTT medium was prepared at a final concentration of 0.5 mg / mL. The MTT medium was warmed and added to the fourth row of the 24-well assay plate in 0.5 mL portions. The cultured epidermis model was transferred to the fourth row of a 24-well assay plate, placed in a CO2 incubator, and subjected to an MTT reaction for 3 hours. After the completion of the MTT reaction, the cultured skin was pinched with tweezers, taken out, and transferred to a 1.5 mL microtube. 300 μL of isopropanol was placed in a microtube, and the cultured epidermis model was completely immersed. Thereafter, the mixture was allowed to stand for 2 hours, and the microtube was vortexed to extract a dye. Extract (200 mL) was placed in each well of a 96-well plate. As a blank (negative control), 200 μL of isopropanol was added to A1. The absorbance at 570 nm and 650 nm was measured with a microplate reader. The value obtained by subtracting the absorbance at 650 nm from the absorbance at 570 nm was used as the measured value, and the viable cell rate of the test substance was calculated from the following formula.

The viable cell rate was classified based on the following criteria, and the skin irritation was evaluated. The results are shown in Tables 3 and 4.
◎: 90% or more
：: 75% or more and less than 90%
Δ: 65% or more and less than 75%
×: 50% or more and less than 65% XX: less than 50%

  As shown in Tables 1 to 4, no detergency was observed in the skin cleansing liquid compositions containing the surfactant alone at a concentration of 0.025 to 2% by weight (Comparative Examples 1 to 10). On the other hand, the skin cleansing liquid composition (Examples 1 to 20) containing the amphiphilic ester (Comparative Examples 11 to 15) which does not show detergency by itself together with 0.025 to 2% by weight of a surfactant. Excellent detergency was obtained by merely applying the mechanical force of the liquid flow without applying any physical friction by simply applying directly to the skin by spraying from a spray-type container. That is, it was shown that skin-friendly cleaning was possible.

  In addition, as shown in Reference Examples 1 to 3, a skin cleansing liquid composition containing a surfactant alone in an amount of more than 2% by weight can obtain excellent cleansing power only by directly applying it to the skin by spraying. On the other hand, in consideration of skin irritation due to the surfactant concentration shown in Reference Examples 1 to 3, when the surfactant concentration is set to 2% by weight or less as shown in Examples 9 to 20, not only the detergency but also the superiority is obtained. It was also hypoallergenic. That is, by setting the surfactant concentration of the liquid for skin cleaning applied to the cleaning method of directly applying to the skin by spraying to 0.025 to 2% by weight, the skin is physically and chemically friendly. It has been shown that washing is possible.

Claims (6)

  A skin cleansing liquid composition comprising (A) a surfactant and (B) an amphipathic ester and used for cleaning without giving physical friction to the skin.   The liquid composition for skin cleansing according to claim 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and (eicosane diacid / tetradecane diacid) polyglyceryl-10. .   The skin cleansing liquid composition according to claim 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.   The liquid composition for cleaning skin according to any one of claims 1 to 3, wherein the content of the component (A) is 0.025 to 2% by weight.   The skin cleansing liquid composition according to claim 4, wherein the content of the component (A) is 0.025 to 0.9% by weight.   A skin cleansing method comprising applying a skin cleansing liquid composition containing (A) a surfactant and (B) an amphiphilic ester to the skin without imparting physical friction to the skin.