JP2019501963A - アミリンおよびアミリンミメティック化合物の非凝集性バイオコンジュゲート、それを含む組成物、ならびにその製造および使用 - Google Patents

アミリンおよびアミリンミメティック化合物の非凝集性バイオコンジュゲート、それを含む組成物、ならびにその製造および使用 Download PDF

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Publication number: JP2019501963A
Authority: JP; Japan
Prior art keywords: amylin; insulin; aggregating; human amylin; composition
Prior art date: 2015-12-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2018549371A

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English (en)

Japanese (ja)

Inventor

ロチャ・エ・リマ、ルイス・マウリシオ・トランバイオリ・ダ

ロサド、ルイス・ヘンリケ・ゲレイロ

グテレス、マリアナ・フェルナンデス・デ・アビラ・ネット

フェレイラ、ブルノ・メロ・ビエイラ・ゴンサルベス

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Universidade Federal do Rio de Janeiro UFRJ

Original Assignee

Universidade Federal do Rio de Janeiro UFRJ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-12-14

Filing date

2016-12-14

Publication date

2019-01-24

2016-12-14 Application filed by Universidade Federal do Rio de Janeiro UFRJ filed Critical Universidade Federal do Rio de Janeiro UFRJ

2019-01-24 Publication of JP2019501963A publication Critical patent/JP2019501963A/ja

Status Pending legal-status Critical Current

Links

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Classifications

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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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JP2018549371A 2015-12-14 2016-12-14 アミリンおよびアミリンミメティック化合物の非凝集性バイオコンジュゲート、それを含む組成物、ならびにその製造および使用 Pending JP2019501963A (ja)

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BRBR1020150312830		2015-12-14
BR102015031283A BR102015031283A2 (pt)	2015-12-14	2015-12-14	Bioconjugado de amilina humana ou de análogos de amilinanão agregantes, composição, métodos para a preparação deuma composição, para o tratamento de uma doença oucondição e para estabilizar um composto amilino-mimético, e,medicamento
PCT/BR2016/050330 WO2017100896A1 (en)	2015-12-14	2016-12-14	Non-agglomerating bioconjugates of amylin and amylin-mimetic compounds, compositions comprising the same, and making and use thereof

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JP2019501963A true JP2019501963A (ja)	2019-01-24

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JP (1)	JP2019501963A (es)
KR (1)	KR20180093059A (es)
CN (1)	CN108431031A (es)
AU (1)	AU2016371260A1 (es)
BR (2)	BR102015031283A2 (es)
CA (1)	CA3008182A1 (es)
MX (1)	MX2018007236A (es)
WO (1)	WO2017100896A1 (es)

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CN110467666A (zh) *	2019-09-17	2019-11-19	湖北强耀生物科技有限公司	一种新型胰岛淀粉样多肽的合成方法
TWI850611B (zh)	2020-12-18	2024-08-01	丹麥商諾佛儂迪克股份有限公司	Glp-1及澱粉素受體之共促效劑

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AU2005320351B2 (en) *	2004-02-11	2010-06-03	Amylin Pharmaceuticals, Llc	Amylin family peptides and methods for making and using them
US8486890B2 (en) *	2006-03-15	2013-07-16	Novo Nordisk A/S	Amylin derivatives
EP2036923A1 (en) *	2007-09-11	2009-03-18	Novo Nordisk A/S	Improved derivates of amylin
US20090104210A1 (en) *	2007-10-17	2009-04-23	Tota Michael R	Peptide compounds for treating obesity and insulin resistance
AU2012208349A1 (en) *	2011-01-20	2013-07-18	Zealand Pharma A/S	Combination of acylated glucagon analogues with insulin analogues
US20140249076A1 (en) *	2011-10-18	2014-09-04	Astrazeneca Pharmaceuticals Lp	Amylin-calcitonin chimeric peptides conjugated to duration enhancing moieties
BR102013017626A2 (pt) *	2013-06-14	2015-02-10	Univ Rio De Janeiro	Bioconjugados não aglomerantes de amilinomiméticos com polietilenoglicol, uso de bioconjugados não aglomerantes de amilinomiméticos com polietilenoglicol, composições farmacêuticas de baixa toxicidade, adjuvante para a prevenção ou tratamento das doenças, medicamento, método de tratamento ou prevenção de doenças.

2015
- 2015-12-14 BR BR102015031283A patent/BR102015031283A2/pt not_active Application Discontinuation
2016
- 2016-12-14 JP JP2018549371A patent/JP2019501963A/ja active Pending
- 2016-12-14 KR KR1020187020206A patent/KR20180093059A/ko unknown
- 2016-12-14 WO PCT/BR2016/050330 patent/WO2017100896A1/en active Application Filing
- 2016-12-14 MX MX2018007236A patent/MX2018007236A/es unknown
- 2016-12-14 AU AU2016371260A patent/AU2016371260A1/en not_active Abandoned
- 2016-12-14 CA CA3008182A patent/CA3008182A1/en not_active Abandoned
- 2016-12-14 CN CN201680073149.XA patent/CN108431031A/zh active Pending
- 2016-12-14 BR BR112018011903A patent/BR112018011903A2/pt not_active Application Discontinuation

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Publication number	Publication date
BR102015031283A2 (pt)	2018-09-18
CA3008182A1 (en)	2017-06-22
CN108431031A (zh)	2018-08-21
BR112018011903A2 (pt)	2018-11-27
MX2018007236A (es)	2019-03-14
AU2016371260A1 (en)	2018-06-21
KR20180093059A (ko)	2018-08-20
WO2017100896A1 (en)	2017-06-22

Publication	Publication Date	Title
JP6727210B2 (ja)	2020-07-22	Ｆｇｆ２１誘導体及びその使用
TWI792596B (zh)	2023-02-11	新穎脂肪酸及其於共軛至生物分子之用途
JP5969461B2 (ja)	2016-08-17	Ｇｌｐ−１受容体作動薬とガストリンとのペプチド複合体及びその使用
TWI689515B (zh)	2020-04-01	Ｇｉｐ-ｇｌｐ-１雙重促效劑化合物及方法
KR102505628B1 (ko)	2023-03-02	글루카곤 및 glp-1 수용체의 장기-작용성 공-효능제
JP6359972B2 (ja)	2018-07-18	Ｇｌｐ−１受容体アゴニストペプチドガストリンコンジュゲート
JP2012529463A (ja)	2012-11-22	２型糖尿病を治療するための、ｇｌｐ−１とｆｇｆ２１との組合せ
AU2017322277A1 (en)	2019-03-28	Amylin analogues
CA2979950A1 (en)	2016-09-22	Amylin analogues
US20200392197A1 (en)	2020-12-17	Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
JP2022509568A (ja)	2022-01-20	修飾されたｇｉｐペプチド類似体
JP2019501963A (ja)	2019-01-24	アミリンおよびアミリンミメティック化合物の非凝集性バイオコンジュゲート、それを含む組成物、ならびにその製造および使用
US20160184401A1 (en)	2016-06-30	Non-agglomerating bioconjugates of amylin and amylin-mimetic compounds, compositions comprising the same, and making and use thereof
EP3394090A1 (en)	2018-10-31	Non-agglomerating bioconjugates of amylin and amylin-mimetic compounds, compositions comprising the same, and making and use thereof
US20240293552A1 (en)	2024-09-05	Ionic liquid compositions
TW202438102A (zh)	2024-10-01	融合化合物及其用途
CN117881415A (zh)	2024-04-12	肥胖症和肥胖症相关障碍的治疗
BR112017011552B1 (pt)	2024-09-17	Derivados de uma proteína do fgf21 e uso terapêutico e/ou profilático dos mesmos

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