JP2016106905A - Blood purification system - Google Patents
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- JP2016106905A JP2016106905A JP2014248441A JP2014248441A JP2016106905A JP 2016106905 A JP2016106905 A JP 2016106905A JP 2014248441 A JP2014248441 A JP 2014248441A JP 2014248441 A JP2014248441 A JP 2014248441A JP 2016106905 A JP2016106905 A JP 2016106905A
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- 239000008280 blood Substances 0.000 title claims abstract description 125
- 210000004369 blood Anatomy 0.000 title claims abstract description 125
- 238000000746 purification Methods 0.000 title claims abstract description 114
- 238000002347 injection Methods 0.000 claims abstract description 48
- 239000007924 injection Substances 0.000 claims abstract description 48
- 239000003814 drug Substances 0.000 claims description 20
- 238000011144 upstream manufacturing Methods 0.000 claims description 12
- 238000001802 infusion Methods 0.000 claims description 9
- 239000000243 solution Substances 0.000 abstract description 12
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- 239000011550 stock solution Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 7
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
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- 238000010438 heat treatment Methods 0.000 description 5
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- 238000001631 haemodialysis Methods 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 238000012806 monitoring device Methods 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
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- 239000011734 sodium Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
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Abstract
Description
本発明は、患者に血液浄化治療を施すための血液浄化器が取り付けられる複数の血液浄化手段と、該血液浄化手段のそれぞれに透析液を供給可能な透析液供給手段とを具備した血液浄化システムに関するものである。 The present invention relates to a blood purification system comprising a plurality of blood purification means to which a blood purification device for performing blood purification treatment on a patient is attached, and a dialysate supply means capable of supplying a dialysate to each of the blood purification means. It is about.
一般に、血液浄化システムは、病院等医療現場における機械室に透析液供給手段を設置しておき、透析室(治療室)に血液浄化手段(透析用監視装置)を設置するとともに、これら透析液供給手段と血液浄化手段とを配管で連結させて構成されている。透析液供給手段は、所定濃度の透析液を作製するとともに、血液浄化手段は、患者に透析治療を施すための血液浄化器(ダイアライザ)を有しつつ複数設置され、透析液供給手段で作製された透析液を配管を介して導入し、血液浄化器に供給することにより血液浄化治療(透析治療)が行われるようになっている。 In general, in a blood purification system, dialysate supply means is installed in a machine room at a medical site such as a hospital, blood purification means (dialysis monitoring device) is installed in a dialysis room (treatment room), and these dialysate supplies are provided. The means and the blood purification means are connected by a pipe. The dialysate supply means prepares a dialysate having a predetermined concentration, and a plurality of blood purification means are provided with blood purifiers (dialyzers) for performing dialysis treatment on a patient, and are prepared by the dialysate supply means. Blood purification treatment (dialysis treatment) is performed by introducing the dialysate through a pipe and supplying it to a blood purifier.
すなわち、機械室に設置された透析液供給手段から透析室に設置された複数の血液浄化手段に分配して透析液を送液し、それぞれの血液浄化手段においてダイアライザに透析液を供給して治療が行われるよう構成されているのである。このように透析液供給手段で作製された透析液を各透析用監視装置に供給する血液浄化システムは、通常、「透析治療用セントラルシステム」と称されるもので、例えば特許文献1にて開示されたものが挙げられる。かかる従来の血液浄化システムによれば、透析液供給手段で一括して作製された透析液を各血液浄化手段における患者に分配して血液浄化治療が行われるので、多人数に対して効率的に血液浄化治療を行わせることができる。 That is, the dialysate supply means installed in the machine room is distributed to a plurality of blood purification means installed in the dialysis room and the dialysate is sent, and the dialysate is supplied to the dialyzer in each blood purification means for treatment. Is configured to be performed. The blood purification system for supplying the dialysate prepared by the dialysate supply means to each monitoring device for dialysis is generally referred to as “dialysis treatment central system”. The thing which was done is mentioned. According to such a conventional blood purification system, the dialysate prepared in a batch by the dialysate supply means is distributed to the patients in each blood purification means, and blood purification treatment is performed. Blood purification treatment can be performed.
しかしながら、上記従来の血液浄化システムにおいては、透析液供給手段で一括して作製された透析液を各血液浄化手段に分配して血液浄化治療が行われるため、供給される透析液は同一の組成から成るものとされ、患者毎に異なる状態(患者の容態や治療方法等)に対応した透析液を供給することが困難であった。なお、患者一人に対して透析液が供給される個人用の血液浄化手段も種々提案されているが、このような個人用の血液浄化手段では、多人数の患者に効率よく透析液を供給することが困難となってしまう。 However, in the above conventional blood purification system, the dialysate prepared in a batch by the dialysate supply means is distributed to each blood purification means to perform blood purification treatment, so the supplied dialysate has the same composition It was difficult to supply dialysate corresponding to different conditions (patient conditions, treatment methods, etc.) for each patient. Various personal blood purification means for supplying dialysate to one patient have been proposed, but such personal blood purification means efficiently supplies dialysate to a large number of patients. It becomes difficult.
本発明は、このような事情に鑑みてなされたもので、多人数の患者に効率よく且つ患者毎に異なる状態に対応させた透析液を供給することができる血液浄化システムを提供することにある。 The present invention has been made in view of such circumstances, and it is an object of the present invention to provide a blood purification system capable of supplying a dialysate efficiently corresponding to a different state for each patient to a large number of patients. .
請求項1記載の発明は、患者に血液浄化治療を施すための血液浄化器が取り付けられる複数の血液浄化手段と、該血液浄化手段のそれぞれに透析液を供給可能な透析液供給手段と、前記透析液供給手段から各血液浄化手段に透析液を流通させて供給するための供給流路とを具備した血液浄化システムにおいて、前記供給流路の途中には、当該供給流路を流通する透析液に特定の成分を注入し得る注入手段が接続されたことを特徴とする。 The invention according to claim 1 is a plurality of blood purification means to which a blood purification device for performing blood purification treatment on a patient is attached, dialysate supply means capable of supplying dialysate to each of the blood purification means, A blood purification system comprising a supply flow path for supplying the dialysate to each blood purification means from the dialysate supply means, and the dialysate flowing through the supply flow path in the middle of the supply flow path An injection means capable of injecting a specific component is connected to this.
請求項2記載の発明は、請求項1記載の血液浄化システムにおいて、前記供給流路が複数に分岐し、その分岐したそれぞれの供給流路に前記血液浄化手段が配設されるとともに、分岐した任意の供給流路に前記注入手段を接続させたことを特徴とする。 According to a second aspect of the present invention, in the blood purification system according to the first aspect, the supply flow path is branched into a plurality of branches, and the blood purification means is disposed in each of the branched supply flow paths. The injection means is connected to an arbitrary supply channel.
請求項3記載の発明は、請求項1又は請求項2記載の血液浄化システムにおいて、前記供給流路の所定部位であって上流側及び下流側にそれぞれ前記血液浄化手段が配設された部位に前記注入手段を接続させたことを特徴とする。 According to a third aspect of the present invention, in the blood purification system according to the first or second aspect, the blood purification system is a predetermined part of the supply flow path, where the blood purification means is disposed on the upstream side and the downstream side, respectively. The injection means is connected.
請求項4記載の発明は、請求項1〜3の何れか1つに記載の血液浄化システムにおいて、血液浄化治療中、前記供給流路を流通する透析液に含有される個別成分の濃度を経時的に計測し得る濃度計測手段を具備したことを特徴とする。 According to a fourth aspect of the present invention, in the blood purification system according to any one of the first to third aspects, during the blood purification treatment, the concentration of the individual components contained in the dialysate flowing through the supply channel is determined over time. It is characterized by having a concentration measuring means capable of measuring automatically.
請求項5記載の発明は、請求項4記載の血液浄化システムにおいて、前記濃度計測手段は、前記供給流路における前記注入手段の上流側及び下流側にそれぞれ接続され、各濃度計測手段で計測された個別成分の濃度を比較可能とされたことを特徴とする。 According to a fifth aspect of the present invention, in the blood purification system according to the fourth aspect, the concentration measuring means is connected to the upstream side and the downstream side of the injecting means in the supply flow path, and is measured by each concentration measuring means. It is possible to compare the concentrations of the individual components.
請求項6記載の発明は、請求項1〜5の何れか1つに記載の血液浄化システムにおいて、前記注入手段は、前記特定の成分を含む薬剤を収容する収容手段と、該収容手段と前記供給流路とを接続する接続流路と、該接続流路に配設されて前記収容手段の特定の成分を含む薬剤を前記供給流路に送り込むための注入ポンプとを有することを特徴とする。 A sixth aspect of the present invention is the blood purification system according to any one of the first to fifth aspects, wherein the injecting unit includes a storing unit that stores a medicine containing the specific component, the storing unit, A connection flow path connecting the supply flow path, and an infusion pump disposed in the connection flow path for feeding a medicine containing a specific component of the storage means into the supply flow path .
請求項1の発明によれば、供給流路の途中には、当該供給流路を流通する透析液に特定の成分を注入し得る注入手段が接続されたので、特定の成分が注入されない透析液及び特定の成分が注入された透析液をそれぞれ供給流路にて流通させることができ、多人数の患者に効率よく且つ患者毎に異なる状態に対応させた透析液を供給することができる。 According to the first aspect of the present invention, since the injection means capable of injecting the specific component into the dialysate flowing through the supply channel is connected to the middle of the supply channel, the dialysate in which the specific component is not injected And the dialysate into which the specific component was inject | poured can each be distribute | circulated in a supply flow path, and the dialysate corresponding to the state which is efficiently different for every patient can be supplied to many patients.
請求項2の発明によれば、供給流路が複数に分岐し、その分岐したそれぞれの供給流路に血液浄化手段が配設されるとともに、分岐した任意の供給流路に前記注入手段を接続させたので、注入手段が接続された供給流路には特定の成分が注入された透析液を流通させ、注入手段が接続されない供給流路には特定の成分が注入されない透析液を流通させることができる。
According to the invention of
請求項3の発明によれば、供給流路の所定部位であって上流側及び下流側にそれぞれ血液浄化手段が配設された部位に注入手段を接続させたので、注入手段が接続された部位より下流には特定の成分が注入された透析液を流通させ、注入手段が接続された部位より上流には特定の成分が注入されない透析液を流通させることができる。
According to the invention of
請求項4の発明によれば、血液浄化治療中、供給流路を流通する透析液に含有される個別成分の濃度を経時的に計測し得る濃度計測手段を具備したので、血液浄化治療中において透析液供給手段から血液浄化手段に供給される透析液の濃度を精度よく且つ自動的に計測でき、透析液の濃度の適否をより正確に判定させることができる。 According to the fourth aspect of the present invention, the blood purification treatment is provided with the concentration measuring means capable of measuring the concentration of the individual components contained in the dialysate flowing through the supply channel over time. The concentration of the dialysate supplied from the dialysate supply means to the blood purification means can be measured accurately and automatically, and the suitability of the dialysate concentration can be determined more accurately.
請求項5の発明によれば、濃度計測手段は、供給流路における注入手段の上流側及び下流側にそれぞれ接続され、各濃度計測手段で計測された個別成分の濃度を比較可能とされたので、注入手段にて特定の成分を適正に注入したか否かの判定を正確に行わせることができる。
According to the invention of
請求項6の発明によれば、注入手段は、特定の成分を含む薬剤を収容する収容手段と、該収容手段と供給流路とを接続する接続流路と、該接続流路に配設されて収容手段の特定の成分を含む薬剤を供給流路に送り込むための注入ポンプとを有するので、供給流路を流通する透析液に対してより確実且つ円滑に特定の成分を注入させることができる。
According to the invention of
以下、本発明の実施形態について図面を参照しながら具体的に説明する。
本実施形態に係る血液浄化システムは、透析液原液から所定濃度の透析液を作製するとともに、その透析液を複数の血液浄化手段に供給するためのものであり、図1に示すように、病院等医療現場における透析室(治療室)に設置された複数の血液浄化手段1と、当該医療現場における機械室に設置された透析液供給装置2、各血液浄化手段1と透析液供給手段2とを連結する供給流路H、H1、H2と、注入手段B1、B2と、濃度計測手段(M1〜M3)とから主に構成される。
Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification system according to the present embodiment is for producing a predetermined concentration of dialysate from a dialysate stock solution and supplying the dialysate to a plurality of blood purification means. As shown in FIG. A plurality of blood purification means 1 installed in a dialysis room (treatment room) at a medical site, a
血液浄化手段1は、監視装置と称されるもので、患者に血液浄化治療(血液透析治療)を施すためのダイアライザ3(血液浄化器)が取り付けられ、透析液供給装置2から供給された透析液を当該ダイアライザ3に供給するためのもので、供給流路H1、H2に沿って複数設置されている。かかる血液浄化手段1は、血液透析治療や他の制御内容(洗浄又は消毒)の指示及び所定の表示を行わせ得るタッチパネルが配設されている。
The blood purification means 1 is called a monitoring device. A dialyzer 3 (blood purifier) for performing blood purification treatment (hemodialysis treatment) on a patient is attached, and dialysis supplied from the
より具体的には、透析室に設置された複数の血液浄化手段1の各々は、図2に示すように、透析液供給装置2から延設された供給流路H1又は供給流路H2から配管L1が引き込まれるとともに、図示しない排液手段に接続された配管L2を具備し、これら配管L1、L2に跨って複式ポンプ8が配設されて構成されている。このうち血液浄化手段1内における配管L1には、当該配管L1を流れる透析液等の電導度を測定する電導度センサ5や当該液体の給液圧を検出する液圧検出センサ6等が配設されている。なお、同図中符号7は、制御手段を示しており、当該制御手段7により血液浄化治療を行わせるための種々制御が行われる。
More specifically, each of the plurality of blood purification means 1 installed in the dialysis chamber is connected to a supply channel H1 extending from the
また、複式ポンプ8からは、配管L1と連通した透析液導入ラインL4と、配管L2と連通した透析液排出ラインL5が延設されており、カプラCを介して当該透析液導入ラインL4の先端をダイアライザ3の透析液導入口3aに接続し得るとともに、カプラCを介して当該透析液排出ラインL5の先端をダイアライザ3の透析液排出口3bに接続し得るよう構成されている。このように、各血液浄化手段1には、それぞれ患者に応じたダイアライザ3が取り付けられるようになっており、当該ダイアライザ3には、患者の血液を体外循環させる血液回路4が接続されることとなる。
Further, a dialysate introduction line L4 communicated with the pipe L1 and a dialysate discharge line L5 communicated with the pipe L2 are extended from the duplex pump 8, and the distal end of the dialysate introduction line L4 via the coupler C is extended. Can be connected to the
複式ポンプ8のポンプ室は、図示しない単一のプランジャにより、配管L1に接続された送液側ポンプ室と、配管L2に接続された排出側ポンプ室とに隔成されており、当該プランジャが往復動することにより、送液側ポンプ室に送られた透析液又は洗浄液をダイアライザ3に供給するとともに、ダイアライザ3内の透析液を排出側ポンプ室に吸入するよう構成されている。さらに、血液浄化手段1内には、複式ポンプ8をバイパスしつつ配管L2と透析液排出ラインL5とを連通する配管L3が形成されており、この配管L3の途中に除水ポンプ9が配設されている。かかる除水ポンプ9を駆動させることにより、ダイアライザ3内を流れる患者の血液に対して除水を行わせることが可能とされる。
The pump chamber of the dual pump 8 is divided into a liquid feeding side pump chamber connected to the pipe L1 and a discharge side pump chamber connected to the pipe L2 by a single plunger (not shown). By reciprocating, the dialysate or the washing solution sent to the liquid feed side pump chamber is supplied to the
なお、複式ポンプ8に代えて、所謂チャンバ形式のものとしてもよいとともに、電導度センサ5や液圧検出センサ6等のセンサ類は、任意のものを配設してもよく若しくは他の汎用的なものを加えるようにしてもよい。さらに、本実施形態においては、当該センサ類を配管L1に配設するようにしているが、他の配管(例えば配管L4)に配設するものとしてもよい。例えば電導度センサ5や液圧検出センサ6等のセンサ類を配管L1又は配管L4の何れか一方に配設させたもの或いは両方に配設させたものとしてもよい。
Instead of the dual pump 8, a so-called chamber type may be used, and sensors such as the
透析液供給手段2は、例えば水処理装置(不図示)で得られた清浄水及び溶解装置(不図示)で作製された透析液原液を用いて所定濃度の透析液を作製し得るとともに、血液浄化手段1のそれぞれに作製した透析液を供給可能なものである。すなわち、透析液供給手段2は、供給流路H、H1、H2を介して複数の血液浄化手段1のそれぞれと接続されており、かかる供給流路Hを介して血液浄化手段1のそれぞれに透析液、洗浄水及び消毒液等の所望の液体を供給し得るよう構成されているのである。なお、本実施形態で適用される透析用原液は、粉末状の重炭酸ナトリウムを含まない薬剤(A剤)を清浄水で溶解することによりA原液を、粉末状の重炭酸ナトリウムから成る薬剤(B剤)を清浄水で溶解することによりB原液を得るものとされているが、液体として提供されるA原液、B原液をタンク等に収容してそのまま使用するものであってもよい。すなわち、透析液供給手段2は、上記の如く得られたA原液、B原液と清浄水とを混合、希釈して透析液を得ることができ、その得られた透析液を血液浄化手段1のそれぞれに供給可能とされているのである。 The dialysate supply means 2 can prepare a dialysate having a predetermined concentration using, for example, clean water obtained by a water treatment device (not shown) and a dialysate stock solution prepared by a dissolution device (not shown) and blood. The dialysate prepared for each of the purification means 1 can be supplied. That is, the dialysate supply means 2 is connected to each of the plurality of blood purification means 1 via supply flow paths H, H1, and H2, and each of the blood purification means 1 is dialyzed via the supply flow path H. It is configured to be able to supply desired liquids such as liquid, washing water and disinfecting liquid. In addition, the undiluted solution for dialysis applied in this embodiment is prepared by dissolving a drug (agent A) that does not contain powdered sodium bicarbonate with clean water, so that the solution A is converted to a drug composed of powdered sodium bicarbonate ( The B stock solution is obtained by dissolving the B agent) with clean water, but the A stock solution and B stock solution provided as liquids may be stored in a tank or the like and used as they are. That is, the dialysate supply means 2 can obtain a dialysate by mixing and diluting the A stock solution, B stock solution and clean water obtained as described above. Each can be supplied.
さらに、本実施形態に係る透析液供給手段2は、後で詳述する濃度計測手段(M1〜M3)と電気的に接続されており、これら濃度計測手段(M1〜M3)の計測値に基づいて供給流路Hを流通する透析液の個別成分の濃度が適正か否かを判定する判定手段10と、判定手段10による判定の結果、透析液の個別成分の濃度が適正範囲を超える場合、表示による報知や音の出力による報知等を行う報知手段11とを有している。 Furthermore, the dialysate supply means 2 according to the present embodiment is electrically connected to concentration measuring means (M1 to M3), which will be described in detail later, and based on the measurement values of these concentration measuring means (M1 to M3). If the determination unit 10 determines whether the concentration of the individual components of the dialysate flowing through the supply flow path H is appropriate, and the determination unit 10 determines that the concentration of the individual components of the dialysate exceeds the appropriate range, And a notification means 11 for performing notification by display, notification by sound output, and the like.
供給流路H、H1、H2は、透析液供給手段2から各血液浄化手段1に透析液(洗浄液及び消毒液も含む)を流通させて供給するための配管から成る。本実施形態においては、透析液供給手段2から供給流路Hが延設し、分岐点Gにて複数(2つ)の供給流路H1、H2に分岐するものとされており、その分岐したそれぞれの供給流路H1、H2に複数の血液浄化手段1が配設されるとともに、分岐した任意の供給流路に注入手段(B1、B2)が接続されている。 The supply flow paths H, H1, and H2 are pipes for supplying dialysis fluid (including cleaning fluid and disinfecting fluid) from the dialysis fluid supply means 2 to each blood purification means 1. In the present embodiment, the supply flow path H extends from the dialysate supply means 2 and branches at the branch point G into a plurality of (two) supply flow paths H1 and H2. A plurality of blood purification means 1 are disposed in the respective supply flow paths H1, H2, and injection means (B1, B2) are connected to any branched supply flow paths.
供給流路H1は、循環加温ユニットYを介して無端状に形成し、透析液を循環させつつ各血液浄化手段1に供給するよう構成されている。かかる循環加温ユニットYは、循環する透析液を加温しつつ循環させるためのもので、本実施形態においては、循環する透析液を外部に排出するための排出管Hdが延設されている。また、供給流路H1における分岐点Gと循環加温ユニットYとの間は、1本の循環しない流路が延設されており、当該循環加温ユニットYから下流側が循環流路とされて複数の血液浄化手段1が配設されている。 The supply flow path H1 is formed in an endless manner via the circulation heating unit Y, and is configured to supply each blood purification means 1 while circulating the dialysate. The circulation warming unit Y is for circulating the circulating dialysate while heating, and in this embodiment, a discharge pipe Hd for discharging the circulating dialysate to the outside is extended. . Further, between the branch point G in the supply flow path H1 and the circulation heating unit Y, one non-circulation flow path is extended, and the downstream side from the circulation heating unit Y is a circulation flow path. A plurality of blood purification means 1 are provided.
供給流路H2は、分岐点Gから延設された1本の循環しない流路から成るもので、終端に排液弁Vが接続されており、当該排液弁Vを開いた状態とすることで、透析液送液開始時に供給流路H2に残った水を押し出して排液し、供給流路H2内を素早く透析液に置換する、或いは透析終了後の洗浄消毒の際に、供給流路H2に残った透析液や消毒液を素早く押し出して排出するようになっている。なお、供給流路H2の途中を更に分岐させ、或いは供給流路H2を循環流路として、その分岐した供給流路のそれぞれ或いは循環した供給流路に血液浄化手段1を配設するようにしてもよい。また、分岐点Gから3つ以上の供給流路を分岐させるようにし、それぞれ分岐した供給流路に血液浄化手段1を配設するようにしてもよい。 The supply flow path H2 is composed of a single non-circulating flow path extending from the branch point G, and the drain valve V is connected to the end, and the drain valve V is opened. Then, the water remaining in the supply flow path H2 at the start of the dialysate feeding is pushed out and drained, and the supply flow path H2 is quickly replaced with the dialysate, or at the time of washing and disinfecting after completion of dialysis. The dialysate and disinfectant remaining in H2 are quickly pushed out and discharged. The blood purification means 1 is arranged in each of the branched supply channels or in the circulated supply channels by further branching the supply channel H2 or by using the supply channel H2 as a circulation channel. Also good. Further, three or more supply channels may be branched from the branch point G, and the blood purification means 1 may be arranged in each branched supply channel.
ここで、本実施形態に係る供給流路H1及び供給流路H2の途中には、当該供給流路H1、H2を流通する透析液に特定の成分を注入し得る注入手段B1、B2が接続されている。注入手段B1は、供給流路H1における分岐点Gと循環加温ユニットYとの間の部位に接続されるとともに、注入手段B2は、供給流路H2の所定部位であって上流側及び下流側にそれぞれ血液浄化手段1が配設された部位に接続されている。 Here, in the middle of the supply flow path H1 and the supply flow path H2 according to the present embodiment, injection means B1 and B2 capable of injecting a specific component into the dialysate flowing through the supply flow paths H1 and H2 are connected. ing. The injection means B1 is connected to a portion of the supply flow path H1 between the branch point G and the circulation heating unit Y, and the injection means B2 is a predetermined portion of the supply flow path H2 that is upstream and downstream. Are connected to the part where the blood purification means 1 is disposed.
これら注入手段B1、B2は、特定の成分を含む薬剤を収容する収容手段D1、D2と、収容手段D1、D2と供給流路H1、H2とを接続する接続流路a、bと、接続流路a、bに配設されて収容手段D1、D2の特定の成分を含む薬剤を供給流路H1、H2に送り込むための注入ポンプP1、P2と、供給流路H1、H2を流通する透析液と特定の成分を含む薬剤とを攪拌、混合するためのミキシングチャンバm1、m2とを有して構成されている。 These injection means B1 and B2 include storage means D1 and D2 for storing a medicine containing a specific component, connection flow paths a and b for connecting the storage means D1 and D2 and the supply flow paths H1 and H2, and a connection flow. Infusion pumps P1 and P2 disposed in the passages a and b for feeding a medicine containing specific components of the storage means D1 and D2 to the supply passages H1 and H2, and dialysate flowing through the supply passages H1 and H2. And mixing chambers m1 and m2 for agitating and mixing the medicine containing a specific component.
収容手段D1、D2に収容される薬剤は、特定の成分として、例えば塩化ナトリウム(NaCl)、塩化カリウム(KCl)、塩化カルシウム(CaCl2)、炭酸水素ナトリウム(NaHCO3)、ブドウ糖(C6H12O6)等を含有するもので、単一の成分を含むものの他、複数の成分を含むものであってもよい。また、注入手段B1で注入される特定の成分と注入手段B2で注入される特定の成分とは、その種類及び濃度が同一であっても異なるものであってもよい。なお、注入手段B1、B2は、自重にて収容手段D1、D2内の薬剤を注入するものとしてもよく、その場合、注入ポンプP1、P2に代えて遮断弁を接続するのが好ましい。 The medicines accommodated in the accommodating means D1 and D2 are, for example, sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl 2 ), sodium hydrogen carbonate (NaHCO 3 ), glucose (C 6 H) as specific components. 12 O 6 ) and the like, and may include a plurality of components in addition to those including a single component. Further, the specific component injected by the injection means B1 and the specific component injected by the injection means B2 may be the same or different in type and concentration. The injection means B1 and B2 may inject the medicine in the storage means D1 and D2 by their own weight. In that case, it is preferable to connect a shutoff valve instead of the injection pumps P1 and P2.
しかして、血液浄化治療中、供給流路H、H1、H2にて透析液を流通させるとともに、注入ポンプP1、P2を駆動させることにより、収容手段D1、D2内の特定の成分を含む薬剤が供給流路H1、H2に注入され、当該透析液と薬剤とがミキシングチャンバm1、m2にて攪拌、混合された後、更に下流の血液浄化手段1に供給されることとなる。これにより、収容手段D1、D2に任意の特定の成分を含む薬剤を収容させて注入させるようにすれば、例えば低カリウム血症の患者には、特定の成分として塩化カリウム(KCl)を注入した透析液を使用し、血圧低下を防止する必要がある患者には、特定の成分として塩化ナトリウム(NaCl)を注入した透析液を使用することができる。 Thus, during blood purification treatment, the dialysis fluid is circulated through the supply channels H, H1, and H2, and the infusion pumps P1 and P2 are driven, whereby a medicine containing a specific component in the storage means D1 and D2 is obtained. After being injected into the supply channels H1 and H2, the dialysate and the drug are agitated and mixed in the mixing chambers m1 and m2, and then supplied to the blood purification means 1 further downstream. As a result, if a medicine containing any specific component is accommodated and infused in the accommodation means D1, D2, for example, potassium chloride (KCl) is infused as a specific component in a hypokalemia patient. For patients who need to use dialysis fluid and prevent blood pressure reduction, dialysis fluid infused with sodium chloride (NaCl) as a specific component can be used.
さらに、本実施形態に係る供給流路H、H1、H2には、血液浄化治療中、供給流路H、H1、H2を流通する透析液に含有される個別成分の濃度(組成濃度)を経時的に計測し得る濃度計測手段(M1〜M3)が接続されている。濃度計測手段M1は、供給流路Hであって分岐点Gより上流側(透析液供給手段2と分岐点Gとの間)に接続されるとともに、濃度計測手段M2は、供給流路H1における循環流路、濃度計測手段M3は、供給流路H2における注入手段B2の下流側の位置にそれぞれ接続されている。 Further, in the supply flow paths H, H1, and H2 according to the present embodiment, the concentrations (composition concentrations) of the individual components contained in the dialysate flowing through the supply flow paths H, H1, and H2 during the blood purification treatment are changed over time. Concentration measuring means (M1 to M3) that can be measured automatically are connected. The concentration measuring means M1 is connected to the supply flow path H upstream from the branch point G (between the dialysate supply means 2 and the branch point G), and the concentration measuring means M2 is connected to the supply flow path H1. The circulation channel and the concentration measuring unit M3 are respectively connected to positions downstream of the injection unit B2 in the supply channel H2.
より具体的に説明すると、濃度計測手段M1(濃度計測手段M2、M3も同様)は、図3に示すように、供給流路Hを流通する透析液を引込み得る引込み流路h1と、該引込み流路h1で引込まれた透析液を収容しつつ個別成分の濃度を計測し得る濃度計測部Nと、引込み流路h1に配設されて濃度計測部Nに透析液を送り込むための注入ポンプPaと、濃度計測部Nで個別成分の濃度が計測された後の透析液を外部に排出する排出流路h2とを有している。 More specifically, as shown in FIG. 3, the concentration measuring unit M1 (same as the concentration measuring units M2 and M3) includes a drawing channel h1 that can draw dialysate flowing through the supply channel H, and the drawing A concentration measuring unit N that can measure the concentration of individual components while accommodating the dialysate drawn in the flow path h1, and an infusion pump Pa that is arranged in the drawing flow path h1 and feeds the dialysate into the concentration measuring unit N. And a discharge channel h2 for discharging the dialysate after the concentration of the individual components is measured by the concentration measuring unit N to the outside.
濃度計測部Nにて計測される個別成分の濃度は、透析液に含有される個別成分の濃度とされ、例えばナトリウム(Na)、カリウム(K)、カルシウム(Ca)、炭酸(CO2)等の濃度が挙げられる。また、濃度計測手段M1は、供給流路Hを流通する透析液に含有される個別成分の濃度に加え、その透析液の浸透圧、pH、電導度を計測し得るものとしてもよく、その場合、供給流路Hを流通する透析液の濃度の適否に加え、浸透圧、pH及び電導度の適否も判定させることができる。 The concentration of the individual component measured by the concentration measuring unit N is the concentration of the individual component contained in the dialysate, such as sodium (Na), potassium (K), calcium (Ca), carbonic acid (CO 2 ), etc. Concentration. Further, the concentration measuring means M1 may measure the osmotic pressure, pH, and conductivity of the dialysate in addition to the concentration of individual components contained in the dialysate flowing through the supply flow path H. In addition to the suitability of the concentration of the dialysate flowing through the supply channel H, the suitability of the osmotic pressure, pH, and conductivity can also be determined.
さらに、濃度計測手段(M1〜M3)は、全て同一の個別成分の濃度を計測するよう構成してもよく、それぞれ異なる個別成分の濃度を計測するようにしてもよい。またさらに、本実施形態においては、引込み流路h1に配設されて濃度計測部Nに透析液を送り込むための注入ポンプPaが配設されているが、かかる注入ポンプPaに代えて、図4に示すように、遮断弁Vaを配設するようにしてもよい。また、本実施形態においては、濃度計測部Nで個別成分の濃度が計測された後の透析液を外部に排出する排出流路h2が延設されているが、かかる排出流路h2に代えて、濃度計測部Nで個別成分の濃度が計測された後の透析液を再び供給流路Hに戻す流路としてもよい。 Further, the concentration measuring means (M1 to M3) may be configured to measure the concentrations of the same individual components, or may measure the concentrations of different individual components. Furthermore, in the present embodiment, an infusion pump Pa is provided in the drawing flow path h1 to send the dialysate to the concentration measuring unit N. Instead of the infusion pump Pa, FIG. As shown in FIG. 4, a shutoff valve Va may be provided. Further, in the present embodiment, the discharge flow path h2 for discharging the dialysate after the concentration of the individual component is measured by the concentration measuring unit N is extended, but instead of the discharge flow path h2, the discharge flow path h2 is extended. The dialysate after the concentration of the individual component is measured by the concentration measuring unit N may be a flow path that returns the supply flow path H again.
しかして、血液浄化治療中(透析治療中)、注入ポンプPaを駆動(遮断弁Vaを開状態としてもよい)させると、供給流路Hを流通する透析液の一部が引込み流路h1に引込まれて濃度計測部Nに至り、当該濃度計測部Nにて流れが止まった状態で貯留されつつ個別成分の濃度が計測され、計測された後の透析液が排出流路h2を流れて排出されることとなる。かかる動作が血液浄化治療中において連続的又は間欠的に繰り返し行われることにより、供給流路Hを流通する透析液に含有される個別成分の濃度を経時的に計測することができる。ここで計測された個別成分の濃度の情報は、透析液供給手段2の判定手段10に送信され、個別成分の濃度が適正か否か判定される。なお、判定手段10は必ずしも透析液供給手段2に配設される必要はなく、例えば濃度計測手段(M1〜M3)のそれぞれに配設されていてもよく、或いは独立して配設されていてもよい。
Thus, during blood purification treatment (during dialysis treatment), when the infusion pump Pa is driven (the shut-off valve Va may be opened), a part of the dialysate flowing through the supply flow path H is drawn into the suction flow path h1. The concentration reaches the concentration measurement unit N, and the concentration of the individual components is measured while being stored in the state where the flow is stopped at the concentration measurement unit N, and the dialysate after the measurement flows through the discharge channel h2 and is discharged Will be. By repeating this operation continuously or intermittently during the blood purification treatment, the concentration of the individual components contained in the dialysate flowing through the supply channel H can be measured over time. Information on the concentration of the individual component measured here is transmitted to the determination unit 10 of the
さらに、本実施形態においては、血液浄化治療前又は血液浄化治療後、透析液供給手段2から各血液浄化手段1に洗浄液又は消毒液を供給可能とされており、濃度計測手段(M1〜M3)は、当該洗浄液又は消毒液に含有される個別成分(例えば塩素(Cl)等)の濃度を計測し得るよう構成するのが好ましい。この場合、洗浄中又は消毒中において透析液供給手段2から血液浄化手段1に供給される洗浄液又は消毒液の濃度の適否を精度よく判定させることができる。
Furthermore, in the present embodiment, a cleaning liquid or a disinfecting liquid can be supplied from the dialysate supply means 2 to each blood purification means 1 before or after the blood purification treatment, and the concentration measuring means (M1 to M3). Is preferably configured to measure the concentration of individual components (for example, chlorine (Cl), etc.) contained in the cleaning liquid or the disinfecting liquid. In this case, whether or not the concentration of the cleaning solution or the disinfecting solution supplied from the
また、本実施形態に係る濃度計測手段M1、M2及び濃度計測手段M1、M3は、供給流路H、H1、H2における注入手段B1、B2の上流側及び下流側にそれぞれ接続され、各濃度計測手段(M1〜M3)で計測された個別成分の濃度を比較可能とされている。これにより、注入手段B1、B2にて特定の成分を適正に注入したか否かの判定を正確に行わせることができる。 Further, the concentration measuring means M1 and M2 and the concentration measuring means M1 and M3 according to the present embodiment are connected to the upstream and downstream sides of the injection means B1 and B2 in the supply flow paths H, H1 and H2, respectively. The concentrations of the individual components measured by the means (M1 to M3) can be compared. As a result, it is possible to accurately determine whether or not a specific component has been properly injected by the injection means B1 and B2.
次に、本実施形態に係る血液浄化システムにおける制御内容の一例について、図5のフローチャートに基づいて説明する。
血液浄化治療(透析治療)が開始されると、透析液供給手段2から供給流路Hにて透析液を流通させて各血液浄化手段1に供給しつつ注入手段B1、B2によって特定の成分を含んだ薬剤を注入し(S1)、濃度計測手段(M1〜M3)にて供給流路H、H1、H2を流れる透析液の個別成分の濃度が計測される(S2)。その後、濃度計測手段(M1〜M3)の計測値が判定手段10に送信され、透析液の個別成分の濃度が適正か否か判定される(S3)。
Next, an example of control contents in the blood purification system according to the present embodiment will be described based on the flowchart of FIG.
When the blood purification treatment (dialysis treatment) is started, the dialysis fluid is circulated from the dialysate supply means 2 through the supply flow path H and supplied to each blood purification means 1 while supplying specific components by the injection means B1 and B2. The contained medicine is injected (S1), and the concentrations of the individual components of the dialysate flowing through the supply channels H, H1, and H2 are measured by the concentration measuring means (M1 to M3) (S2). Thereafter, the measured values of the concentration measuring means (M1 to M3) are transmitted to the determining means 10, and it is determined whether or not the concentration of the individual components of the dialysate is appropriate (S3).
そして、S3にて透析液の個別成分の濃度が適正(適正範囲内)であると判定されると、透析液供給手段2による透析液の供給が継続される(S4)とともに、S3にて透析液の個別成分の濃度が適正でない(適正範囲外)と判定されると、S5にて透析液供給手段2に設けられている透析液原液注入ポンプ、又は注入ポンプP1、P2のそれぞれ、あるいはその全てを制御して、供給流路H、H1、H2の透析液の個別成分の濃度が適正となるように駆動し、S2に戻って以降の制御を再び行う。なお、濃度計測手段(M1〜M3)の故障を発見するために、注入手段B1、B2による薬剤の注入を行わない状態にて、濃度計測手段(M1〜M3)の各計測値を比較する、あるいはそれぞれの濃度計測手段(M1〜M3)に図示しない複数系統のセンサを設けて両者を比較するようにしてもよい。 When it is determined in S3 that the concentration of the individual components of the dialysate is appropriate (within an appropriate range), the dialysate supply means 2 continues to supply the dialysate (S4) and dialysis is performed in S3. If it is determined that the concentration of the individual components of the liquid is not appropriate (outside the proper range), each of the dialysate stock solution injection pumps or injection pumps P1 and P2 provided in the dialysate supply means 2 in S5, or All are controlled to drive the concentration of the individual components of the dialysate in the supply flow paths H, H1, and H2 to be appropriate, and the process returns to S2 and the subsequent control is performed again. In addition, in order to find out the failure of the concentration measuring means (M1 to M3), the measured values of the concentration measuring means (M1 to M3) are compared in a state where the medicine is not injected by the injecting means B1 and B2. Alternatively, a plurality of systems of sensors (not shown) may be provided in each concentration measuring means (M1 to M3) to compare the two.
上記実施形態によれば、供給流路H1、H2の途中には、当該供給流路H1、H2を流通する透析液に特定の成分を注入し得る注入手段B1、B2が接続されたので、特定の成分が注入されない透析液及び特定の成分が注入された透析液をそれぞれ供給流路H1、H2にて流通させることができ、多人数の患者に効率よく且つ患者毎に異なる状態に対応させた透析液を供給することができる。 According to the above embodiment, the injection means B1 and B2 that can inject a specific component into the dialysate flowing through the supply flow paths H1 and H2 are connected in the middle of the supply flow paths H1 and H2. The dialysis fluid into which no components are injected and the dialysis fluid into which specific components are injected can be circulated in the supply flow paths H1 and H2, respectively. Dialysate can be supplied.
また、供給流路Hが複数に分岐し、その分岐したそれぞれの供給流路H1、H2に血液浄化手段1が配設されるとともに、分岐した任意の供給流路H1、H2に注入手段B1、B2を接続させたので、注入手段B1、B2が接続された供給流路H、H1、H2には特定の成分が注入された透析液を流通させ、注入手段B1、B2が接続されない供給流路H、H1、H2には特定の成分が注入されない透析液を流通させることができる。 Further, the supply flow path H is branched into a plurality of parts, and the blood purification means 1 is disposed in each of the branched supply flow paths H1 and H2, and the injection means B1 is provided in any branched supply flow paths H1 and H2. Since B2 is connected, the dialysis fluid into which a specific component is injected is circulated through the supply flow paths H, H1, and H2 to which the injection means B1 and B2 are connected, and the supply flow path to which the injection means B1 and B2 are not connected A dialysate in which a specific component is not injected can be circulated through H, H1, and H2.
さらに、供給流路H2の所定部位であって上流側及び下流側にそれぞれ血液浄化手段1が配設された部位に注入手段B2を接続させたので、注入手段B2が接続された部位より下流には特定の成分が注入された透析液を流通させ、注入手段B2が接続された部位より上流には特定の成分が注入されない透析液を流通させることができる。 Further, since the injection means B2 is connected to a predetermined portion of the supply flow path H2 where the blood purification means 1 is disposed on the upstream side and the downstream side, respectively, the injection means B2 is connected to the downstream side of the portion where the injection means B2 is connected. Can circulate a dialysis fluid into which a specific component has been injected, and circulate a dialysis fluid into which a specific component is not injected upstream from the site where the injection means B2 is connected.
またさらに、血液浄化治療中、供給流路H、H1、H2を流通する透析液に含有される個別成分の濃度を経時的に計測し得る濃度計測手段(M1〜M3)を具備したので、血液浄化治療中において透析液供給手段2から血液浄化手段1に供給される透析液の濃度を精度よく且つ自動的に計測でき、透析液の濃度の適否をより正確に判定させることができる。 Furthermore, since blood concentration treatment means (M1 to M3) capable of measuring the concentration of individual components contained in the dialysate flowing through the supply channels H, H1, and H2 over time during blood purification treatment, blood is provided. During the purification treatment, the concentration of the dialysate supplied from the dialysate supply means 2 to the blood purification means 1 can be accurately and automatically measured, and the suitability of the dialysate concentration can be determined more accurately.
また、本実施形態に係る注入手段B1、B2は、特定の成分を含む薬剤を収容する収容手段D1、D2と、該収容手段D1、D2と供給流路H1、H2とを接続する接続流路a、bと、該接続流路a、bに配設されて収容手段D1、D2の特定の成分を含む薬剤を供給流路H1、H2に送り込むための注入ポンプP1、P2とを有するので、供給流路H1、H2を流通する透析液に対してより確実且つ円滑に特定の成分を注入させることができる。 In addition, the injection means B1 and B2 according to the present embodiment include accommodation means D1 and D2 that contain a medicine containing a specific component, and connection flow paths that connect the accommodation means D1 and D2 and the supply flow paths H1 and H2. a, b, and infusion pumps P1, P2 that are disposed in the connection channels a, b and feed the medicines containing specific components of the storage means D1, D2 into the supply channels H1, H2. A specific component can be more reliably and smoothly injected into the dialysate flowing through the supply flow paths H1 and H2.
以上、本実施形態に係る血液浄化システムついて説明したが、本発明はこれに限定されるものではなく、例えば濃度計測手段を血液浄化手段1内の供給流路(図2における配管L1又は透析液導入ラインL4等)に接続するものとしてもよく、上記とは異なる特定の成分を注入手段B1、B2にて注入するもの、或いは上記とは異なる個別成分の濃度を血液浄化治療中、経時的に計測し得るものとしてもよい。また、注入手段B1、B2及び濃度計測手段(M1〜M3)の配設位置及び配設個数は、他の形態としてもよい。さらに、配管H、H1、H2は、必ずしもこの組み合わせである必要がなく、配管H1又は配管H2の何れか一方、また別の組み合わせがあってもよい。なお、本実施形態においては、血液透析治療を行うシステムとされているが、他の血液浄化治療を行う血液浄化システムに適用するようにしてもよい。 Although the blood purification system according to the present embodiment has been described above, the present invention is not limited to this. For example, the concentration measuring means is a supply flow path in the blood purification means 1 (pipe L1 or dialysate in FIG. 2). May be connected to the introduction line L4, etc., and a specific component different from the above may be injected by the injection means B1 and B2, or a concentration of an individual component different from the above may be changed over time during the blood purification treatment. It is good also as what can be measured. Further, the arrangement positions and the number of arrangement of the injection means B1 and B2 and the concentration measurement means (M1 to M3) may take other forms. Further, the pipes H, H1, and H2 are not necessarily in this combination, and either one of the pipe H1 or the pipe H2 or another combination may be provided. In addition, in this embodiment, although it is set as the system which performs a hemodialysis treatment, you may make it apply to the blood purification system which performs another blood purification treatment.
供給流路の途中に当該供給流路を流通する透析液に特定の成分を注入し得る注入手段が接続された血液浄化システムであれば、他の機能が付加されたもの等にも適用することができる。 If the blood purification system is connected to an injection means capable of injecting a specific component into the dialysate flowing through the supply flow channel in the middle of the supply flow channel, the blood purification system may be applied to a device to which other functions are added. Can do.
1 血液浄化手段
2 透析液供給装置
3 ダイアライザ(血液浄化器)
4 血液回路
5 電導度センサ
6 液圧検出センサ
7 制御手段
10 判定手段
11 報知手段
B1、B2 注入手段
H 供給流路
M1〜M3 濃度計測手段
DESCRIPTION OF SYMBOLS 1 Blood purification means 2
4
Claims (6)
該血液浄化手段のそれぞれに透析液を供給可能な透析液供給手段と、
前記透析液供給手段から各血液浄化手段に透析液を流通させて供給するための供給流路と、
を具備した血液浄化システムにおいて、
前記供給流路の途中には、当該供給流路を流通する透析液に特定の成分を注入し得る注入手段が接続されたことを特徴とする血液浄化システム。 A plurality of blood purification means to which a blood purifier for performing blood purification treatment on a patient is attached;
Dialysate supply means capable of supplying dialysate to each of the blood purification means;
A supply channel for circulating and supplying the dialysate from the dialysate supply means to each blood purification means;
In the blood purification system comprising
In the middle of the supply channel, an injection means for injecting a specific component into the dialysate flowing through the supply channel is connected.
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JPH03261480A (en) * | 1990-03-09 | 1991-11-21 | Nissho Corp | Dialyzer |
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JP2013533061A (en) * | 2010-07-31 | 2013-08-22 | フレセニウス・メディカル・ケア・ドイチュラント・ゲーエムベーハー | Device and method for detecting the direction of fluid flow through a dialyzer |
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JPH03261480A (en) * | 1990-03-09 | 1991-11-21 | Nissho Corp | Dialyzer |
JPH06245995A (en) * | 1993-02-19 | 1994-09-06 | Wilfried Schal | Preparation of hemodialyzing liquid containing hydrogencarbonate |
US20020057625A1 (en) * | 1999-06-04 | 2002-05-16 | Russell Richard M. | Centralized bicarbonate mixing system |
JP2013533061A (en) * | 2010-07-31 | 2013-08-22 | フレセニウス・メディカル・ケア・ドイチュラント・ゲーエムベーハー | Device and method for detecting the direction of fluid flow through a dialyzer |
JP2013150767A (en) * | 2011-12-29 | 2013-08-08 | Tomita Pharmaceutical Co Ltd | Preparation apparatus and preparation method for dialysis fluid of variable bicarbonate ion concentration type, dialysate of variable bicarbonate ion concentration type, and dialysis system of variable bicarbonate ion concentration type |
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