JP2015522080A - スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物 - Google Patents
スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物 Download PDFInfo
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Abstract
Description
を含み、式中、
R1、R2、R3、R4、R5、R6、およびR7は独立して、
H、OH、
O−Rx(式中、Rxが、アルキル、シクロアルキル、アルキルシクロアルキル、アシル、エステル、チオエステルである);
任意に置換されたアルキル(例えば、酸素、ケイ素、硫黄で任意に置換されるか、またはOH、O−アルキル、SH、S−アルキル、NH2、NH−アルキルで任意に置換されたC1〜C12直鎖または分枝鎖アルキル);シクロアルキル(例えば、C3〜C7シクロアルキル);アルキルシクロアルキル(例えば、C4〜C12アルキルシクロアルキル);ヘテロシクロアルキル(例えば、該ヘテロ環は、O、S、またはNから選択される1つまたは2つのヘテロ原子を含み、C2〜C6ヘテロシクロアルキルが含まれる);アルキルヘテロシクロアルキル(例えば、該ヘテロ環が、O、S、またはNから選択される1つまたは2つのヘテロ原子を含み、C3〜C11アルキルヘテロシクロアルキルが含まれ、Nが複素環式環に存在するとき、窒素原子は、アミド、カルバミン酸塩、または尿素の形態であり得ることを含む);任意に置換されたアルケニル(例えば、酸素、ケイ素、硫黄で任意に置換されるか、OH、O−アルキル、SH、S−アルキル、NH2、NH−アルキルで任意に置換されたC1〜C12直鎖または分枝鎖アルケニル);任意に置換されたアルキニル(例えば、酸素、ケイ素、硫黄で任意に置換されるか、OH、O−アルキル、SH、S−アルキル、NH2、NH−アルキルで任意に置換されたC1〜C12直鎖または分枝鎖アルキニル);
任意に置換されたアリール(例えば、フェニル、置換フェニル、ナフチル、置換ナフチル);任意に置換されたアルキルアリール(例えば、アルキルフェニル、アルキル置換フェニル、アルキルナフチル、アルキル置換ナフチル);任意に置換されたヘテロアリール(例えば、それらすべてが任意に置換された、ピリジル、フラニル、チオフェニル、ピロリル、オキサゾリル、イソオキサゾリル、チアゾリル、ジアゾリル、ピラゾリル、トリアゾリル);任意に置換されたアルキルヘテロアリールから選択され、かつ
あるいはR6およびR7は、一緒に結合を形成し、それらが結合している窒素原子を含む環をともに形成し得、
あるいはR1およびR2は、それらが結合している窒素原子を含む3〜8員複素環式環をともに形成し得、
あるいはR4およびR5は、それらが結合している窒素原子を含む、アジリジン、ピロリル、イミダゾリル、ピラゾリル、インドリル、インドリニル、ピロリジニル、ピペラジニル、およびピペリジルの群から選択される環をともに形成し得る。
H、メチル、エチル、プロピル、またはイソプロピルから選択されてもよく、
および残りの置換基のそれぞれ:R1、R2、R4、およびR5、またはR1、R2、およびR6、またはR1、R2、およびR6、またはR1およびR2、またはR1はそれぞれ独立して、
H;任意に置換されたアルキル(例えば、酸素、ケイ素、硫黄で任意にヘテロ置換されるか、またはOH、O−アルキル、SH、S−アルキル、NH2、NH−アルキルで任意に置換されたC1〜C12直鎖または分枝鎖アルキル);任意に置換されたアルケニル(例えば、酸素、ケイ素、硫黄で任意にヘテロ置換されるか、またはOH、O−アルキル、SH、S−アルキル、NH2、NH−アルキルで任意に置換されたC1〜C12直鎖または分枝鎖アルケニル);任意に置換されたアルキニル(例えば、酸素、ケイ素、硫黄で任意にヘテロ置換されるか、またはOH、O−アルキル、SH、S−アルキル、NH2、NH−アルキルで任意に置換されたC1〜C12直鎖または分枝鎖アルキニル);シクロアルキル(例えば、C3〜C7シクロアルキル);アルキルシクロアルキル(例えば、C4〜C12アルキルシクロアルキル);ヘテロシクロアルキル(例えば、該ヘテロ環が、O、S、またはNから選択される1つまたは2つのヘテロ原子を含み、C2〜C6ヘテロシクロアルキルが含まれる);アルキルヘテロシクロアルキル(例えば、該ヘテロ環が、O、S、またはNから選択される1つまたは2つのヘテロ原子を含み、C3〜C11アルキルヘテロシクロアルキルが含まれ、Nが複素環式環に存在するとき、窒素原子は、アミド、カルバミン酸塩、または尿素の形態であり得ることを含む);アリール(例えば、フェニル、置換フェニル、ナフチル、置換ナフチル);アルキルアリール(例えば、アルキルフェニル、アルキル置換フェニル、アルキルナフチル、アルキル置換ナフチル);ヘテロアリール(例えば、それらすべてが任意に置換された、ピリジル、フラニル、チオフェニル、ピロリル、オキサゾリル、イソオキサゾリル、チアゾリル、ジアゾリル、ピラゾリル、トリアゾリル);アルキルヘテロアリールから選択され、
あるいはR1およびR2は、それらが結合している窒素原子を含む3〜8員複素環式環をともに形成し得、
あるいはR4およびR5は、それらが結合している窒素原子を含む、アジリジン、ピロリル、イミダゾリル、ピラゾリル、インドリル、インドリニル、ピロリジニル、ピペラジニル、およびピペリジルの群から選択される環をともに形成し得る。
トリアゾール:
トリアジン:
ジヒドロトリアジン:
7環式ビグアナイド:
Aは、天然または非天然アミノ酸のプロトン化形態であり、
Bは、酸のジアニオンであり、
Cは、式Iの化合物のプロトン化形態である。
Aは、アラニン、アスパラギン酸、アスパラギン、アルギニン、グリシン、グルタミン、グルタミン酸リシン、フェニルアラニン、チロシン、セリン、スレオニン、トリプトファン、ロイシン、イソロイシン、ヒスチジン、メチオニン、プロリン、システイン、またはシスチンから選択される、天然アミノ酸のプロトン化形態であり、
Bは、シュウ酸、マロン酸、クエン酸、マレイン酸、フマル酸、酒石酸、アスパラギン酸、グルタミン酸等から選択される酸のジアニオンであり、かつ
Cは、式Iの化合物のプロトン化形態である。
国際公開第WO/2010/143733号−Novel fused cyclic compound and use thereof;国際公開第WO/2010/123016号−Carboxylic acid compound;国際公開第WO/2010/123017号−tetrazole compound;国際公開第WO/2010/091176号−Phthalazine−containing antidiabetic compounds;国際公開第WO/2010/085522号−Pentafluorosulpholane−containing antidiabetic compounds;国際公開第WO/2010/085528号−Bridged and fused antidiabetic compounds;国際公開第WO/2010/085525号−Bridged and fused heterocyclic antidiabetic compounds;国際公開第WO/2010/045258号−Spirocyclic GPR40 modulators;国際公開第WO/2010/012650号−Compounds for the treatment of metabolic diseases;国際公開第WO/2009/058237号−Antidiabetic tricyclic compounds;国際公開第WO/2009/054423号−Oxadiazolidinedione compound;国際公開第WO/2009/054423号−Oxadiazolidinedione compound;国際公開第WO/2009/054390号−Thiazolidinedione compound;国際公開第WO/2009/048527号−Substituted biphenyl GPR40 modulators;国際公開第WO/2009/038204号−Novel long−chain fatty acid derivative compound and G−protein−coupled receptor agonist containing the compound as active ingredient;国際公開第WO/2008/139987号−G−protein−conjugated receptor agonist;国際公開第WO/2008/130514号−Substituted biphenyl phenoxy−;thiophenyl− and aminophenylpropanoic acid GPR40 modulators;国際公開第WO/2008/066097号−Carboxylic acid derivative;国際公開第WO/2008/054675号−Antidiabetic bicyclic compounds;国際公開第WO/2008/054674号−Antidiabetic bicyclic compounds;国際公開第WO/2008/030520号−heterocyclic GPR40 modulators;国際公開第WO/2008/001931号−fused cyclic compounds;国際公開第WO/2007/136572号−antidiabetic bicyclic compounds;国際公開第WO/2007/136573号−antidiabetic bicyclic compounds;国際公開第WO/2007/123225号−Oxadiazolidinedione compound;国際公開第WO/2007/049050号−Modulators of GPR40 for the treatment of diabetes;国際公開第WO/2007/013689号−Cyclopropanecarboxylic acid compound;国際公開第WO/2007/013689号−Cyclopropanecarboxylic acid compound;国際公開第WO/2006/083781号−Antidiabetic bicyclic compounds;国際公開第WO/2006/083612号−Antidiabetic bicyclic compounds;国際公開第WO/2006/038738号−Receptor function regulating agent;国際公開第WO/2006/011615号−Remedy for diabetes;国際公開第WO/2005/095338号−Alkoxyphenylpropanoic acid derivatives;国際公開第WO/2005/087710号−Aminophenylpropanoic acid derivative;国際公開第WO/2005/063729号−3−(4−benzyloxyphenyl)propanoic acid derivatives;国際公開第WO/2005/063725号−Phenylpropanoic acid derivatives;国際公開第WO/2005/051890号−Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40;国際公開第WO/2004/106276号−Condensed ring compound;国際公開第WO/2004/072650号−Diagnostics and therapeutics for diseases associated with G protein−coupled receptor 40(GPR40);国際公開第WO/2004/041266号−Receptor function controlling agent;国際公開第WO/2006/102653号−Methods and compositions for treating insulin resistance and obesity−induced diseases;国際公開第WO/2006/052566号−GPR41 and modulators thereof for the treatment of insulin−related disorders;国際公開第WO/2004/038421号−Diagnostics and therapeutics for diseases associated with human G protein−coupled receptor 41(GPR41);国際公開第WO/2001/061359号−Identification of modulators of GPR41 or GPR42 activity;国際公開第WO/2011/151436号−Azepin−derivatives as derivatives as G− protein coupled receptor(GPR43)agonists;国際公開第WO/2011/092284号−Novel amino acid derivatives and their use as GPR43 receptor modulators;国際公開第WO/2011/073376号−Pyrrolidine or thiazolidine carboxylic acid derivatives,pharmaceutical composition and methods for use in treating metabolic disorders as agonists of G− protein coupled receptor 43(GPR43);国際公開第WO/2006/102653号−Methods and compositions for treating insulin resistance and obesity−induced diseases;国際公開第WO/2006/036688号−GPR43 and modulators thereof for the treatment of metabolic−related disorders;国際公開第WO/2004/038405号−Diagnostics and therapeutics for diseases associated with G protein−coupled receptor 43(GPR43);国際公開第WO/2003/057730号−Ligand for g−protein coupled receptor GPR43 and uses thereof;国際公開第WO/2000/028083号−Mouse 7−transmembrane receptor GPR43、そのそれぞれは、参照することによりその全体が組み込まれる。これらの薬剤は、長時間および/または遅延放出を利用することもできるが、概して、即時放出用に製剤化される。
Compounds for the treatment of metabolic disorders;国際公開第WO/2010/103335号−Compounds for the treatment of metabolic disorders;国際公開第WO/2010/095663号−Fused heterocyclic ring compound;国際公開第WO/2010/088518号−Heterocyclic modulators of GPR119 for treatment of disease;国際公開第WO/2010/084944号−Novel pyrrolo[2,3−d]pyrimidine compound;国際公開第WO/2010/074271号−Therapeutic agent for diabetes;国際公開第WO/2010/048149号−Heterocyclic modulators of GPR119 for treatment of disease;国際公開第WO/2010/029089号−Combination therapy for the treatment of diabetes and related conditions;国際公開第WO/2010/013849号−GPR119 agonist;国際公開第WO/2010/008739号−Aryl GPR119 agonists and uses thereof;国際公開第WO/2010/009195号−Bicyclic heterocycle derivatives and use thereof as GPR119 modulators;国際公開第WO/2010/009183号−Pyridone and pyridazone analogues as GPR119 modulators;国際公開第WO/2010/006191号−4−phenoxymethylpiperidines as modulators of GPR119 activity;国際公開第WO/2010/004348号−Heterocyclic GPCR agonists;国際公開第WO/2010/004347号−Heterocyclic GPCR agonists;国際公開第WO/2010/001166号−Thiazole derivatives as GPR119 modulators;国際公開第WO/2009/150144号−New GPR119modulators;国際公開第WO/2009/141238号−GPR119 receptor agonists;国際公開第WO/2009/143049号−Bicyclic heterocycle derivatives and use thereof as GPR119 modulators;国際公開第WO/2009/126245号−Methods of using a G protein−coupled receptor to identify peptide YY(PYY)secretagogues and compounds useful in the treatment of conditions modulated by PYY;国際公開第WO/2009/126535号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2009/123992号−Oxymethylene aryl compounds and uses thereof;国際公開第WO/2009/117421号−Heterocyclic modulators of GPR119 for treatment of disease;国際公開第WO/2009/106561号−Pyrazine compounds for treating GPR119 related disorders;国際公開第WO/2009/106565号−Agonists of GPR119;国際公開第WO/2009/105715号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2009/105722号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2009/105717号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2009/055331号−Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119;国際公開第WO/2009/050522号−Azetidinyl G−protein coupled receptor agonists;国際公開第WO/2009/050523号−Azetidinyl G−protein coupled receptor agonists;国際公開第WO/2009/038974号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2009/034388号−Compounds for the treatment of metabolic disorders;国際公開第WO/2009/014910号−N−azacyclic substituted pyrrole,pyrazole,imidazole,triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders;国際公開第WO/2009/012277号−Method for modulating GPR119 G protein−coupled receptor and selected compounds;国際公開第WO/2009/012275号−Pyridone GPR119 G protein−coupled receptor agonists;国際公開第WO/2008/137436号−[6,5]−bicyclic GPR119 G protein−coupled receptor agonists;国際公開第WO/2008/137435号−[6,6] and [6,7]−bicyclic GPR119 G protein−coupled receptor agonists;国際公開第WO/2008/130584号−Pyrimidinone derivatives and methods of use thereof;国際公開第WO/2008/130581号−Pyrimidinone derivatives and methods of use thereof;国際公開第WO/2008/130615号−Tetrahydropyrido[4,3−d]pyrimidinone derivatives and methods of use thereof;国際公開第WO/2008/109702号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2008/097428号−Compounds and compositions as modulators of GPR119 activity;国際公開第WO/2008/025799号−Pyridazine compounds for treating GPR119 related disorders;国際公開第WO/2008/025798号−Pyridine compounds for treating GPR119 related disorders;国際公開第WO/2008/025800号−Pyrimidine compounds for treating GPR119 related disorders;国際公開第WO/2008/008887号−GPR119 agonists for treating metabolic disorders;国際公開第WO/2008/008895号−GPR119 agonists for the treatment of diabetes and related disorders;国際公開第WO/2007/120702号−Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis;and combination therapy relating thereto;国際公開第WO/2007/120689号−Methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual;国際公開第WO/2007/116229号−Heterocyclic GPCR agonists;国際公開第WO/2007/116230号−Azetidine derivatives as G−protein coupled receptor(GPR119)agonists;国際公開第WO/2006/076231号−Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP−1 level、そのそれぞれは、参照することによりその全体が組み込まれる。これらの薬剤は、長時間および/または遅延放出を利用することもできるが、概して、即時放出用に製剤化される。
[1] 直接的ではない質問を通して服薬遵守および有害事象を評価し、対象に用量を増加させることを思い出させるための電話
[2] 対象が子宮摘出術を受けたことがある、または閉経後である場合を除き、すべての女性対象において妊娠検査が必要とされた。
[3] 来院2および4においてGLP−1、PYY、血漿グルコース、インスリン、およびトリグリセリド。来院3および5においてGLP−1、PYY、血漿グルコース、インスリン、トリグリセリド、およびメトホルミン。
来院2および来院4における食事負荷の後。来院3および来院5における4日目の午後の用量および5日目の午前の用量。
[1] PYY、GLP−1、血漿グルコース、インスリン、およびトリグリセリドのアセスメントのための採取時点当たり6mLの総血液量。
[2] 対象は、20分間以内に標準化された朝食を消費することを指示される。
[1] PYY、GLP−1、血漿グルコース、インスリン、およびトリグリセリドのアセスメントのための採取時点当たり6mLの総血液量。
[2] 対象は、20分間以内に標準化された朝食を消費することを指示される。
[3] メトホルミンのアセスメントのための採取時点当たり2mLの総血液量。
薬物動態評価
略号:NA=該当なし;t=用量投与後の最後の数量化濃度
注釈:対象内のCV%は、AUC0-tに対して24.2、Cmaxに対して26.3であった。
[1] (1000mg メトホルミンIR、1000mg メトホルミンDR、または500mg メトホルミンDR)/1000mg メトホルミンIR。
総PYY
略号:BL=ベースライン(1日目)、EOT=治療の終わり(5日目)、geo.=幾何学、t=用量投与後の最後の数量化濃度。
[1] 各治療のEOT(5日目)/BL(1日目)
略号:BL=ベースライン(1日目)、EOT=治療の終わり(5日目)、geo.=幾何学、t=用量投与後の最後の数量化濃度。
[1] 各治療のEOT(5日目)/BL(1日目)。
略号:BL=ベースライン(1日目)、EOT=治療の終わり(5日目)、t=用量投与後の最後の数量化濃度。
[1] 各治療のEOT(5日目)/BL(1日目)。
略号:BL=ベースライン(1日目)、EOT=治療の終わり(5日目)、t=用量投与後の最後の数量化濃度。
[1] 各治療のEOT(5日目)/BL(1日目)。
略号:BL=ベースライン(1日目)、EOT=治療の終わり(5日目)、t=用量投与後の最後の数量化濃度。
[1] 各治療のEOT(5日目)/BL(1日目)。
SS:統計的に有意である(p値<0.0001)
治療A:1000mg メトホルミンIR BID(2x500mg メトホルミンHCl錠剤[即時放出])
治療B:500mg メトホルミンDR BID(1x500mg メトホルミンHCl錠剤[遅延放出 pH6.5 腸溶コーティング])
治療C:1000mg メトホルミンDR BID(2x500mg メトホルミン HCl錠剤[遅延放出 pH6.5 腸溶コーティング])
SS:統計的に有意である(p値<0.0001)
治療B:500mg メトホルミンDR BID(1x500mg メトホルミンHCl錠剤[遅延放出 pH6.5 腸溶コーティング])
治療C:1000mg メトホルミンDR BID(2x500mg メトホルミン HCl錠剤[遅延放出 pH6.5 腸溶コーティング])
治療D:2000mg メトホルミンXR QD(4x500mg メトホルミンHCl錠剤[長時間放出])
−経時的な空腹時血漿グルコースのベースラインからの変化
−経時的なHbA1cのベースラインからの変化
−経時的な体重のベースラインからの変化
*Met XR 2000mg QD午後群は、1週間にわたるMet XR 1000mg QDで開始し、次いで、残りの試験期間に対して2000mg QDへの増加の前に1週間にわたる1500mg QDに滴定する。
・プラセボ(EFP0079)
・Met DR(EFB0080):500mgのメトホルミンHCl遅延放出錠剤(pH6.5の腸溶コーティングを有する)
・Met DR(EFB0081):300mgのメトホルミンHCl遅延放出錠剤(pH6.5の腸溶コーティングを有する)
・Met XR:500mgのメトホルミンHCl長時間放出錠剤(Glucophage(登録商標)XR)
・空腹時血漿グルコース
・HbA1c
・体重
・血漿メトホルミン
・インスリン
・PYY
・GLP−1
・有害事象
・心電図
・身体検査
・バイタルサイン
・臨床化学、血液学、および尿検査
Claims (19)
- 心血管代謝性リスクを減少させること必要とする患者において心血管代謝性リスクを減少させるための固定用量併用剤形であって、少なくとも1つのビグアナイド化合物、少なくとも1つのスタチン、および少なくとも1つの追加の活性薬剤を含む、前記固定用量併用剤形。
- 前記少なくとも1つの追加の活性薬剤が、抗高血圧剤、抗血小板薬剤、利尿剤、胆汁酸捕捉剤、インクレチン模倣剤および賦活剤、抗肥満剤、経口抗糖尿病剤、ならびに抗アテローム硬化剤からなる群から選択される、請求項1に記載の併用剤形。
- 少なくとも2つ、3つ、または4つの追加の活性薬剤を含む、請求項1または2に記載の併用剤形。
- 950、900、もしくは850mg未満のメトホルミンまたは他のビグアナイドを含む、請求項1に記載の併用剤形。
- 約300mg〜約900mgのメトホルミン、より好ましくは約400mg〜約800mgのメトホルミンを含む、請求項1に記載の併用剤形。
- 前記経口抗糖尿病剤が、スルホニルウレア、非スルホニルウレア、チアゾリジンジオン、二重PPARアゴニスト、ジペプチジルペプチダーゼ4阻害剤、SGLT1またはSGLT2阻害剤、メグリチニド、α−グルコシダーゼ阻害剤、GPR40、GPR120、GPR119、GPR41、およびGPR43のアゴニストからなる群から選択される、請求項6に記載の併用剤形。
- 前記抗高血圧剤が、β遮断薬、α遮断薬、α/β混合遮断薬、ジヒドロピリジンおよび非ジヒドロピリジン等のカルシウムチャネル遮断薬、レニン阻害剤、ACE阻害剤、およびアンジオテンシンII受容体アンタゴニストからなる群から選択される、請求項2に記載の併用剤形。
- 前記抗血小板薬が、シクロオキシゲナーゼ阻害剤、ADP受容体阻害剤、ホスホジエステラーゼ阻害剤、アデノース(adenose)再取り込み阻害剤、トロンボキサンシンターゼまたは受容体阻害剤、アナグレリド、プラスグレル、およびクロリクロメンからなる群から選択される、請求項2に記載の併用剤形。
- 前記利尿剤が、ループ利尿剤、チアジド系利尿剤、チアジド様利尿剤、およびカリウム保持性利尿剤からなる群から選択される、請求項2に記載の併用剤形。
- 前記メトホルミンまたは他のビグアナイド化合物が、小腸への送達に標的化され、前記製剤が、5.0または5.5以上のpHで腸溶性にコーティングされた経口剤形を含む、請求項2に記載の併用剤形。
- 前記ビグアナイド化合物が、遠位小腸への送達に標的化され、前記製剤が、6.0または6.5以上のpHで腸溶性にコーティングされた経口剤形を含む、請求項1に記載の併用剤形。
- 前記併用剤形が、メトホルミン、少なくとも1つのスタチン、少なくとも1つの抗高血圧剤、および任意に少なくとも1つの抗血小板薬を含む、請求項1に記載の併用剤形。
- 前記抗高血圧剤が、ACE阻害剤またはアンジオテンシンII受容体アンタゴニストを含む、請求項12に記載の併用剤形。
- 約600〜800mgのメトホルミン、約20〜40mgのシンバスタチンまたはアトルバスタチン、約20〜25mgのベナゼプリル、リシノプリル、またはロサルタン、および約75〜90mgのアスピリンを含む、請求項12に記載の併用剤形。
- 心血管代謝性リスクを減少させることを必要とする患者において心血管代謝性リスクを減少させる方法であって、請求項1〜13のいずれか1項に記載の併用剤形を前記患者に投与することを含む、前記方法。
- 心血管代謝性リスクを減少させることが、前記患者の根本的な代謝障害を治療することを含む、請求項15に記載の方法。
- 心血管代謝性リスクを減少させることが、前記患者における心血管疾患を治療することを含む、請求項15に記載の方法。
- 前記併用剤形が、前記患者に1日1回投与される、請求項15に記載の方法。
- 前記併用剤形が、前記患者に1日1回、朝に投与される、請求項18に記載の方法。
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US13/547,022 US8796338B2 (en) | 2011-01-07 | 2012-07-11 | Biguanide compositions and methods of treating metabolic disorders |
US13/734,966 | 2013-01-05 | ||
US13/734,966 US9211263B2 (en) | 2012-01-06 | 2013-01-05 | Compositions and methods of treating metabolic disorders |
PCT/US2013/050142 WO2014011926A1 (en) | 2012-07-11 | 2013-07-11 | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
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AR091739A1 (es) | 2015-02-25 |
EP2872127A1 (en) | 2015-05-20 |
HK1210825A1 (en) | 2016-05-06 |
AU2013290100A1 (en) | 2015-01-29 |
WO2014011926A1 (en) | 2014-01-16 |
IL236647A0 (en) | 2015-02-26 |
CA2878625A1 (en) | 2014-01-16 |
JP2018087214A (ja) | 2018-06-07 |
CN104780915A (zh) | 2015-07-15 |
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