JP2013532130A5 - - Google Patents
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- JP2013532130A5 JP2013532130A5 JP2013510364A JP2013510364A JP2013532130A5 JP 2013532130 A5 JP2013532130 A5 JP 2013532130A5 JP 2013510364 A JP2013510364 A JP 2013510364A JP 2013510364 A JP2013510364 A JP 2013510364A JP 2013532130 A5 JP2013532130 A5 JP 2013532130A5
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- represented
- compound
- pharmaceutically acceptable
- acceptable salt
- structural formula
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Claims (5)
からなる群より選択される構造式で表される化合物、またはその薬学的に許容され得る塩。
A compound represented by a structural formula selected from the group consisting of: or a pharmaceutically acceptable salt thereof.
で表される請求項１に記載の化合物、またはその薬学的に許容され得る塩。 Structural formula
The compound of Claim 1 represented by these, or its pharmaceutically acceptable salt.
で表される請求項１に記載の化合物、またはその薬学的に許容され得る塩。 Structural formula
The compound of Claim 1 represented by these, or its pharmaceutically acceptable salt.
で表される請求項２に記載の化合物、またはその薬学的に許容され得る塩。 Structural formula
The compound of Claim 2 represented by these, or its pharmaceutically acceptable salt.
で表される請求項３に記載の化合物、またはその薬学的に許容され得る塩。
Structural formula
The compound of Claim 3 represented by these, or its pharmaceutically acceptable salt.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33499110P | 2010-05-14 | 2010-05-14 | |
| US61/334,991 | 2010-05-14 | ||
| US37074510P | 2010-08-04 | 2010-08-04 | |
| US61/370,745 | 2010-08-04 | ||
| US37586310P | 2010-08-22 | 2010-08-22 | |
| US61/375,863 | 2010-08-22 | ||
| PCT/US2011/036701 WO2011143669A2 (en) | 2010-05-14 | 2011-05-16 | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015049960A Division JP5937247B2 (en) | 2010-05-14 | 2015-03-12 | Compositions and methods for treating neoplasms, inflammatory diseases, and other disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532130A JP2013532130A (en) | 2013-08-15 |
| JP2013532130A5 true JP2013532130A5 (en) | 2014-11-06 |
| JP5715241B2 JP5715241B2 (en) | 2015-05-07 |
Family
ID=49052897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510364A Active JP5715241B2 (en) | 2010-05-14 | 2011-05-16 | Compositions and methods for treating neoplasms, inflammatory diseases, and other disorders |
| JP2015049960A Active JP5937247B2 (en) | 2010-05-14 | 2015-03-12 | Compositions and methods for treating neoplasms, inflammatory diseases, and other disorders |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015049960A Active JP5937247B2 (en) | 2010-05-14 | 2015-03-12 | Compositions and methods for treating neoplasms, inflammatory diseases, and other disorders |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP5715241B2 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103119160B (en) * | 2010-05-14 | 2016-06-01 | 达那-法伯癌症研究所 | For regulating compositions and the method for metabolism |
| HUE031073T2 (en) | 2010-05-14 | 2017-06-28 | Dana Farber Cancer Inst Inc | Thienotriazolodiazepine compounds for treating neoplasia |
| BR112014032105A2 (en) * | 2012-06-25 | 2017-08-01 | Oncoethix Sa | method for cancer treatment |
| EP3030242A1 (en) * | 2013-08-06 | 2016-06-15 | Oncoethix GmbH | Method of treating diffuse large b-cell lymphoma (dlbcl) using a bet-bromodomain inhibitor |
| CN105849110B (en) | 2013-11-08 | 2019-08-02 | 达纳-法伯癌症研究所有限公司 | Use the combination treatment for cancer of bromine structural domain and additional terminals (BET) protein inhibitor |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| KR20180035785A (en) * | 2015-06-26 | 2018-04-06 | 텐샤 세러퓨틱스 인코포레이티드 | Treatment of NUT mesenteric carcinoma |
| RU2018112953A (en) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | ACETAMIDTIENOTRIAZOLODIAZODEPINE AND WAYS OF THEIR APPLICATION |
| CA2996974A1 (en) * | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| US20190192532A1 (en) * | 2015-10-02 | 2019-06-27 | Dana-Farber Cancer Institute | Combination therapy of bromodomain inhibitors and checkpoint blockade |
| ES2882066T3 (en) * | 2016-02-15 | 2021-12-01 | Univ Michigan Regents | Fused 1,4-oxazepines and related analogs as BET bromodomain inhibitors |
| WO2018109053A1 (en) * | 2016-12-16 | 2018-06-21 | F. Hoffmann-La Roche Ag | Process for the manufacture of diazepine derivatives |
| CN109503618A (en) * | 2017-09-14 | 2019-03-22 | 成都海创药业有限公司 | A kind of BRD4 inhibitor |
| JP2021527136A (en) * | 2018-06-13 | 2021-10-11 | ディブリー・アーゲー | Preparation of condensed triazepine derivatives and their use as BET inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3106197A (en) * | 1996-06-12 | 1998-01-07 | Japan Tobacco Inc. | Cytokine production inhibitors, triazepine compounds, and intermediates there of |
| US7589167B2 (en) * | 2000-02-22 | 2009-09-15 | J. David Gladstone Institutes | ZA loops of bromodomains |
| MXPA05009151A (en) * | 2003-02-27 | 2005-10-20 | Abbott Lab | Heterocyclic kinase inhibitors. |
| JP5478262B2 (en) * | 2007-12-28 | 2014-04-23 | 田辺三菱製薬株式会社 | Anticancer drug |
| RS54645B1 (en) * | 2009-11-05 | 2016-08-31 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
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2011
- 2011-05-16 JP JP2013510364A patent/JP5715241B2/en active Active
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2015
- 2015-03-12 JP JP2015049960A patent/JP5937247B2/en active Active