JP2013172792A - Medical image diagnostic apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medical image diagnostic apparatus with which the relationship between the body action state and the generation timing of biological reaction can be obtained.SOLUTION: A medical image diagnostic apparatus includes an internal body image acquisition part, an input part, an appearance image acquisition part, a storage part and a control part. The internal body image acquisition part continuously or intermittently irradiates a prescribed portion of a test subject body with X-rays to acquire a plurality of internal body images different in time phase from one another. The input part inputs generation information showing the generation of a prescribed biological reaction of the test subject body. The appearance image acquisition part photographs a prescribed portion at a photographing timing corresponding to the input of at least the generation information to acquire the appearance image. The control part stores the appearance image acquired at the photographing timing and the timing information showing the generation timing of the biological reaction in relation to each other, in the storage part. Further, the control part stores at least one of a plurality of the biological images acquired by the biological image acquisition part, in the storage part.

Description

  Embodiments described herein relate generally to a medical image diagnostic apparatus.

  A medical image diagnostic apparatus is an apparatus that acquires an image representing the inside of a subject. As medical image diagnostic apparatuses, X-ray CT (Computed Tomography) apparatuses and X-ray imaging apparatuses are known.

  An X-ray CT apparatus is an apparatus that scans a subject with X-rays, collects data, and processes the collected data with a computer, thereby imaging the inside of the subject. Specifically, the X-ray CT apparatus emits X-rays to a subject a plurality of times from different directions, detects X-rays transmitted through the subject with an X-ray detector, and generates a plurality of detection data. collect. The collected detection data is A / D converted by the data collection unit and then transmitted to the data processing system. The data processing system forms projection data by pre-processing the detection data. Subsequently, the data processing system executes a reconstruction process based on the projection data to form tomographic image data.

  The data processing system forms volume data based on a plurality of tomographic image data as further reconstruction processing. The volume data is a data set representing a three-dimensional distribution of CT values corresponding to a three-dimensional region of the subject. When acquiring volume data, volume scanning using a multi-row X-ray detector is applied. Also, by repeatedly performing the volume scan, a plurality of volume data having different time phases can be acquired (4D scan).

  The X-ray CT apparatus can perform MPR (Multi Planar Reconstruction) display by rendering volume data in an arbitrary direction. The cross-sectional image (MPR image) displayed in MPR includes an orthogonal three-axis image and an oblique image. An orthogonal triaxial image is an axial image showing a cross section orthogonal to the body axis, a sagittal image showing a cross section of the subject along the body axis, and a coronal showing a cross section of the subject along the body axis. Show the image. The oblique image is an image showing a cross section other than the orthogonal three-axis image. Further, the X-ray CT apparatus renders volume data by setting an arbitrary line of sight, thereby forming a pseudo 3D image when the 3D region of the subject is viewed from this line of sight.

  The X-ray imaging apparatus is an apparatus that images the inside of the subject by irradiating the subject with X-rays and detecting the transmitted X-rays with a two-dimensional X-ray detector. Imaging methods using an X-ray imaging apparatus include normal imaging for obtaining a still image by single X-ray irradiation and fluoroscopic imaging for obtaining a moving image by irradiating X-rays continuously or intermittently.

JP 2010-259653 A JP 2011-4966 A

  Volume scanning and 4D scanning of the X-ray CT apparatus and fluoroscopic imaging of the X-ray imaging apparatus are used for observing the motion state of the joint. In particular, 4D scanning and fluoroscopic imaging are used for continuous imaging while operating a joint. In such joint examinations, it is desired to grasp the relationship between the operation state of the joint and the timing at which the patient feels pain. That is, it is desired to grasp how pain is generated in a state where the joint is bent.

  In other medical fields as well, it is desired to grasp the relationship between the action state of the body and the occurrence timing of a biological reaction (life reaction). For example, there is a case where it is desired to grasp a change in the pain state according to the body position. However, such information cannot be obtained by the conventional medical image diagnostic apparatus.

  The problem to be solved by the present invention is to provide a medical image diagnostic apparatus capable of obtaining the relationship between the motion state of the body and the generation timing of the biological reaction.

  The medical image diagnostic apparatus according to the embodiment includes an in-vivo image acquisition unit, an input unit, an appearance image acquisition unit, a storage unit, and a control unit. The in-vivo image acquisition unit acquires a plurality of in-vivo images having different time phases by continuously or intermittently irradiating a predetermined part of the subject with X-rays. The input unit inputs generation information representing the occurrence of a predetermined biological reaction of the subject. The appearance image acquisition unit acquires an appearance image by imaging a predetermined part at least at an imaging timing corresponding to the generation information input. The control unit stores the appearance image acquired at the imaging timing and timing information indicating the occurrence timing of the biological reaction in the storage unit in association with each other. Further, the control unit causes the storage unit to store at least one of the plurality of in-vivo images acquired by the in-vivo image acquisition unit.

It is a block diagram showing the structure of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a block diagram showing the structure of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is the schematic for demonstrating the process which the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment performs. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a block diagram showing the structure of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a flowchart showing the operation example of the medical image diagnostic apparatus (X-ray CT apparatus) which concerns on embodiment. It is a block diagram showing the structure of the medical image diagnostic apparatus which concerns on a modification. It is a block diagram showing the structure of the medical image diagnostic apparatus which concerns on a modification.

  A medical image diagnostic apparatus according to an embodiment will be described with reference to the drawings. Hereinafter, examples of the X-ray CT and the X-ray imaging apparatus will be described.

<First Embodiment>
[Constitution]
With reference to FIG.1 and FIG.2, the structural example of the X-ray CT apparatus 1 which concerns on embodiment is demonstrated. Note that “image” and “image data” may be identified with each other.

  FIG. 1 shows the overall configuration of the X-ray CT apparatus 1. In FIG. 2, the parts related to the acquisition of the CT image are collectively represented as the in-vivo image acquisition unit 100. The in-vivo image acquisition unit 100 includes the gantry device 10, the couch device 30, the scan control unit 42, the preprocessing unit 431, and the reconstruction processing unit 432 in FIG. 1. When the reconstruction processing unit 432 forms volume data, the in-vivo image acquisition unit 100 also includes a rendering processing unit 433.

  As shown in FIG. 1, the X-ray CT apparatus 1 includes a gantry device 10, a bed device 30, a console device 40, and an appearance image acquisition unit 50.

(Mounting device)
The gantry device 10 is an apparatus that irradiates the subject E with X-rays and collects X-ray detection data transmitted through the subject E. The gantry device 10 includes an X-ray generator 11, an X-ray detector 12, a rotating body 13, a high voltage generator 14, a gantry driver 15, an X-ray diaphragm 16, a diaphragm driver 17, And a data collection unit 18.

  The X-ray generator 11 includes an X-ray tube that generates X-rays (for example, a vacuum tube that generates a cone-shaped or pyramid-shaped beam (not shown)). The generated X-rays are exposed to the subject E.

  The X-ray detection unit 12 includes a plurality of X-ray detection elements (not shown). The X-ray detection unit 12 detects X-ray intensity distribution data (hereinafter sometimes referred to as “detection data”) indicating the intensity distribution of X-rays transmitted through the subject E with an X-ray detection element, and the detection data is Output as a current signal.

  As the X-ray detector 12, for example, a two-dimensional X-ray detector (surface detector) in which a plurality of detection elements are arranged in two directions (slice direction and channel direction) orthogonal to each other is used. The plurality of X-ray detection elements are provided, for example, in 320 rows along the slice direction. By using a multi-row X-ray detector in this way, a three-dimensional region having a width in the slice direction can be imaged with one scan (volume scan). The slice direction corresponds to the body axis direction of the subject E, and the channel direction corresponds to the rotation direction of the X-ray generation unit 11.

  The rotating body 13 is a member that supports the X-ray generation unit 11 and the X-ray detection unit 12 at positions facing each other with the subject E interposed therebetween. The rotating body 13 has an opening that penetrates in the slice direction. A top plate on which the subject E is placed is inserted into the opening. The rotating body 13 is rotated along a circular orbit centered on the subject E by the gantry driving unit 15.

  The high voltage generator 14 applies a high voltage to the X-ray generator 11. This high voltage is defined by parameters such as tube voltage, tube current, and application time (imaging time). The X-ray generator 11 generates X-rays based on this high voltage. The X-ray diaphragm unit 16 forms a slit (opening), and changes the size and shape of the slit so that the X-ray fan angle (divergence angle in the channel direction) output from the X-ray generation unit 11 and the X-rays are changed. Adjust the cone angle (spreading angle in the slice direction). The diaphragm drive unit 17 drives the X-ray diaphragm unit 16 to change the size and shape of the slit.

  A data collection unit 18 (DAS: Data Acquisition System) collects detection data from the X-ray detection unit 12 (each X-ray detection element). Further, the data collection unit 18 converts the collected detection data (current signal) into a voltage signal, periodically integrates and amplifies the voltage signal, and converts it into a digital signal. Then, the data collecting unit 18 transmits the detection data converted into the digital signal to the console device 40.

(Bed apparatus)
A subject E is placed on a top plate (not shown) of the bed apparatus 30. The couch device 30 moves the subject E placed on the top plate in the body axis direction. Moreover, the couch device 30 moves the top plate in the vertical direction.

(Console device)
The console device 40 is used for operation input to the X-ray CT apparatus 1. Further, the console device 40 reconstructs CT image data (tomographic image data and volume data) representing the internal form of the subject E from the detection data input from the gantry device 10. The console device 40 includes a control unit 41, a scan control unit 42, a processing unit 43, a storage unit 44, a display unit 45, and an operation unit 46.

  The control unit 41, the scan control unit 42, and the processing unit 43 include, for example, a processing device and a storage device. As the processing apparatus, for example, a CPU (Central Processing Unit), a GPU (Graphic Processing Unit), or an ASIC (Application Specific Integrated Circuit) is used. The storage device is configured to include, for example, a ROM (Read Only Memory), a RAM (Random Access Memory), and an HDD (Hard Disc Drive).

  The storage device stores a computer program for executing the function of each unit of the X-ray CT apparatus 1. The processing device implements the above functions by executing these computer programs. The control unit 41 controls each unit of the apparatus.

  The scan control unit 42 integrally controls operations related to X-ray scanning. This integrated control includes control of the high voltage generation unit 14, control of the gantry driving unit 15, control of the aperture driving unit 17, and control of the bed apparatus 30.

  The control of the high voltage generator 14 is to control the high voltage generator 14 so that a predetermined high voltage is applied to the X-ray generator 11 at a predetermined timing. The control of the gantry driving unit 15 controls the gantry driving unit 15 so as to rotationally drive the rotating body 13 at a predetermined timing and a predetermined speed. The control of the diaphragm control unit 17 controls the diaphragm driving unit 17 so that the X-ray diaphragm unit 16 forms a slit having a predetermined size and shape. The control of the couch device 30 is to control the couch device 30 so that the top plate is moved to a predetermined position at a predetermined timing.

  In the volume scan, the scan is executed with the position of the top plate fixed. In the helical scan, the scan is executed while moving the top plate.

  The processing unit 43 performs various processes on the data input from the gantry device 10 (data collection unit 18) and the data input from the appearance image acquisition unit 50. The processing unit 42 includes a preprocessing unit 431, a reconstruction processing unit 432, a rendering processing unit 433, an image specifying unit 434, and a time phase detection unit 436.

  The preprocessing unit 431 performs preprocessing including logarithmic conversion processing, offset correction, sensitivity correction, beam hardening correction, and the like on the detection data from the gantry device 10 to generate projection data.

  The reconstruction processing unit 432 generates CT image data (tomographic image data or volume data) based on the projection data generated by the preprocessing unit 431. As the reconstruction processing of the tomographic image data, for example, any method such as a two-dimensional Fourier transform method or a convolution / back projection method can be applied.

  The volume data is generated by interpolating a plurality of reconstructed tomographic image data. As volume data reconstruction processing, for example, an arbitrary method such as a cone beam reconstruction method, a multi-slice reconstruction method, an enlargement reconstruction method, or the like can be applied. In the volume scan using the multi-row X-ray detector described above, a wide range of volume data can be reconstructed.

  The rendering processing unit 433 can execute, for example, MPR processing and volume rendering. The MPR process is an image process for generating MPR image data representing a section by setting an arbitrary section to the volume data generated by the reconstruction processing unit 432 and performing a rendering process. Volume rendering generates pseudo three-dimensional image data representing the three-dimensional region of the subject E by sampling volume data along an arbitrary line of sight (ray) and adding the values (CT values). Image processing.

(Image identification part)
First, the premise of the process executed by the image specifying unit 434 will be described. An image (CT image) formed by the reconstruction processing unit 432 is called an in-vivo image, and an image acquired by the appearance image acquisition unit 50 is called an appearance image. The in-vivo image is an image depicting the inside of the subject E. The appearance image is an image depicting the appearance of the subject E.

  The in-vivo image acquisition unit 100 acquires a plurality of in-vivo images by irradiating a predetermined part of the subject E with X-rays continuously or intermittently. This predetermined part is, for example, a joint part. As a plurality of in-vivo images, a plurality of volume data along a time series obtained by 4D scanning, a plurality of tomographic images or pseudo three-dimensional images along a time series obtained by rendering these volume data, and a predetermined cross section are repetitive. There are a plurality of tomographic images along the time series obtained by scanning.

  The operation unit 46 is used to input generation information indicating the occurrence of a biological reaction of the subject E. Some of these biological reactions occur with pain. Examples of biological reactions that occur with pain include pain recognition, vocalization, facial expression changes, respiratory changes, sweating changes, electrocardiogram changes, blood pressure changes, electromyogram changes, brain wave changes, pupil diameter changes There are changes.

  The operator of the operation unit 46 operates the operation unit 46 in response to the occurrence of such a biological reaction. Upon receiving the operation, the operation unit 46 inputs a signal as generation information to the control unit 41. The operator is the subject E (patient) or another person (doctor, nurse, radiographer, etc.).

  The appearance image acquisition unit 50 acquires an appearance image by imaging a predetermined part of the subject E at least at the imaging timing corresponding to the input of the occurrence information. This shooting may be a still image shooting or a moving image shooting. Details of the appearance image acquisition unit 50 will be described later.

  With the above preparation, the image specifying unit 434 will be described. The image specifying unit 434 specifies a function (first specifying unit) for specifying an in-vivo image acquired substantially simultaneously with the generation information input and an appearance image acquired substantially simultaneously with the generation information input. Function (second specific part). Hereinafter, these functions will be described.

  The image specifying unit 434 specifies the in-vivo image acquired substantially simultaneously with the input of the generation information among the plurality of in-vivo images acquired by the in-vivo image acquiring unit 100. As will be described later, the process of specifying the in-vivo image may include the process of specifying the appearance image. The control unit 41 associates the identified in-vivo image, the appearance image acquired at the imaging timing corresponding to the input of the occurrence information of the biological reaction, and the timing information indicating the occurrence timing of the biological reaction in the storage unit 44. Remember.

  Examples of timing information include character string information or image information indicating the occurrence timing of a biological reaction, a flag indicating the occurrence timing, and the like. The character string information includes the file name of each image data of the in-vivo image and the appearance image, the folder name of the folder in which each image data is stored. Further, the image information includes image data stored together with the image data of the in-vivo image and the appearance image, information superimposed on the image data, and the like.

  In addition, when the appearance image acquisition unit 50 performs shooting of moving images or when shooting a predetermined part of the subject E repeatedly, such as when shooting a plurality of still images, the image specifying unit 434 acquires sequentially. Among the appearance images to be displayed, the appearance images acquired substantially simultaneously with the input of the occurrence information of the biological reaction are specified. The appearance image specifying process can be executed in the same manner as the in-vivo image specifying process. The control unit 41 stores the identified appearance image and the timing information in the storage unit 44 in association with each other. Further, the control unit 41 causes the storage unit 44 to store at least one of the plurality of in-vivo images acquired by the in-vivo image acquisition unit 100. The in-vivo image to be stored may be an in-vivo image specified as described above, one or more in-vivo images selected by other methods, or all of a plurality of in-vivo images.

  “Substantially simultaneous” allows not only completely simultaneous but also an arbitrarily set error. This error is determined according to, for example, the acquisition interval of the in-vivo image and / or the appearance image. An example of processing executed by the image specifying unit 434 will be described. In the following example, the examination target is a predetermined joint part of the subject E. The in-vivo image and the appearance image are obtained by photographing the range including the joint part.

  When the first processing example is applied, the image specifying unit 434 includes an analysis unit 435 (see FIG. 2). The analysis unit 435 acquires first shape information indicating the shape of the joint part by analyzing the appearance image acquired by the appearance image acquisition unit 50. Furthermore, the analysis unit 435 analyzes each of the plurality of in-vivo images acquired by the in-vivo image acquisition unit 100, thereby acquiring second shape information indicating the shape of the joint part drawn in the in-vivo image. .

  Here, the in-vivo image and the appearance image are obtained by drawing joint portions from (almost) the same direction. As a method for realizing this, the appearance image drawing direction can be adjusted according to the drawing direction of the in-vivo image, and vice versa. The former is applied when an X-ray imaging apparatus is used, and can be realized, for example, by providing an imaging apparatus for appearance images in the vicinity of an X-ray tube or an X-ray detector.

  The latter is applied, for example, when forming volume data, and can be realized by rendering a tomographic image of a cross section corresponding to the drawing direction of the appearance image from the volume data. As an example of the method of specifying the cross section, a data range corresponding to the joint part in the volume data is specified, and the shape of the two-dimensional region corresponding to the joint part in the appearance image is substantially (of the three-dimensional data range) (almost). The matching two-dimensional data range can be specified by using image processing such as pattern matching, and the direction of the two-dimensional data range in the coordinate system defined in the volume data can be set as the target cross-sectional direction.

  Each shape information represents, for example, the shape of the contour of the body surface in the range including the joint part. In this case, the analysis unit 435, for example, a predetermined color (skin color) or a predetermined shape (the shape of the joint part and its peripheral part) based on the pixel value (luminance value, RGB value, CT value, etc.) of each image. ) Is specified. Further, the analysis unit 435 specifies an image region (contour region) corresponding to the contour of the image region. As an example of this case, an outline region Ga in the CT image G is shown in FIG. The contour region itself or its shape (including the approximate shape) is the first and second shape information.

  The shape information is not limited to the contour shape, and may be any information that represents the shape of the joint part. For example, the contour shape and the core wire shape of the bone can be used as the shape information. As an example of these cases, FIG. 3 shows a bone outline region Gb and a core region Gc in the CT image G. In addition, when using a core wire shape, it is also possible to obtain an angle formed by two or more bone core wires located at a joint site and use this angle information as shape information. Even when the contour shape is used, the directions of two parts that contact each other at the joint part (for example, the upper arm and the forearm in the elbow joint) are specified based on the contour shape, and an angle formed by these two directions is obtained. The information can be shape information.

  The analysis unit 435 performs the above process on each of the plurality of in-vivo images acquired by the in-vivo image acquisition unit 100. Thereby, a plurality of pieces of second shape information are obtained. The image specifying unit 434 specifies an in-vivo image corresponding to the second shape information that substantially matches the first shape information based on the appearance image among the obtained plurality of second shape information. This processing can be performed using image processing such as pattern matching for both pieces of shape information, for example. The in-vivo image thus identified is used as the in-vivo image acquired substantially simultaneously with the input of the biological reaction occurrence information.

  A second processing example will be described. Even when this processing example is applied, the image specifying unit 434 includes an analysis unit 435 (see FIG. 2). The analysis unit 435 analyzes the appearance image acquired by the appearance image acquisition unit 50, thereby acquiring first feature position information indicating the position of a predetermined feature region in the appearance image. Further, the analysis unit 435 analyzes each of the plurality of in-vivo images acquired by the in-vivo image acquisition unit 100, thereby acquiring second feature position information indicating the position of the feature region in the in-vivo image.

  This feature region is an image region corresponding to a predetermined part of the human body or an image region corresponding to an artificial object photographed together with the subject E. Examples of the former include a predetermined bone or a predetermined part thereof, a predetermined organ or a predetermined part thereof. Examples of the latter include a marker affixed to the subject E, an insert (such as a catheter) inserted into the subject E, and an artifact (such as an osteosynthesis bolt) provided in the body of the subject E. .

  The process of specifying the feature region can be performed based on, for example, pattern matching based on the shape of the feature region, or pixel values (luminance value, RGB value, CT value, etc.) unique to the feature region. Further, the number of specified characteristic regions is one or more arbitrary numbers. When two or more feature areas are specified, information indicating the positional relationship (distance, orientation, etc.) of these feature areas can be used as the feature position information.

  Each feature region may be one point (one pixel) or an image region composed of a plurality of pixels. In the latter case, information indicating the size and shape of the image area can be used as the feature position information.

  The analysis unit 435 performs the above process on each of the plurality of in-vivo images acquired by the in-vivo image acquisition unit 100. Thereby, a plurality of pieces of second feature position information are obtained. The image specifying unit 434 acquires the body reaction occurrence information substantially simultaneously with the input of the biological reaction occurrence information based on the obtained second feature position information and the first feature position information based on the appearance image. Identify the image.

  This processing is performed by, for example, comparing the first feature position information with the second feature position information, the positional relationship between two or more feature areas indicated in the first feature position information, or the size or shape of the feature areas, etc. And (substantially) the second feature position information indicating the same feature region can be selected. The in-vivo image corresponding to the selected second feature position information is used as the in-vivo image acquired substantially simultaneously with the input of the biological reaction occurrence information.

  A third processing example will be described. When this processing example is applied, it is not necessary to provide the analysis unit 435 in the image specifying unit 434 (see FIG. 1). In the case of performing this processing example, the image specifying unit 434 includes first input timing information indicating the input timing of biological reaction occurrence information by the operation unit 46 and second in-vivo image acquisition timing by the in-vivo image acquisition unit 100. Receive input timing information. Then, the image specifying unit 434 specifies the in-vivo image corresponding to the second input timing information received substantially simultaneously with the first input timing information.

  The first input timing information is sent from the control unit 41 to the image specifying unit 434 in response to the input of a signal from the operation unit 46 to the control unit 41. The second input timing information is input to the image specifying unit 434 each time an in-vivo image at each time phase is formed or each time phase scan is performed.

  When the time required for the pre-processing and reconstruction processing is sufficiently short, the reconstruction processing unit 432, the rendering processing unit 433, the control unit 41, and the gantry device 10 can be used at any timing of image formation or scanning. Second input timing information is input to the image specifying unit 434. On the other hand, in other cases, the second input timing information is input from the control unit 41 or the gantry device 10 to the image specifying unit 434 at the timing when the scan is performed.

  The image input unit 434 receives second input timing information sequentially. The image specifying unit 434 that has received the input of the first input timing information corresponding to the operation of the operation unit 46, for example, the second input timing information input at the timing closest to the input timing of the first input timing information. Is identified. Then, the image specifying unit 434 sets the in-vivo image corresponding to the specified second input timing information as the in-vivo image acquired substantially simultaneously with the input of the biological reaction occurrence information.

(Time phase detector)
The in-vivo image acquisition unit 100 acquires a new in-vivo image based on the appearance image and timing information stored in the storage unit 44 under the control of the control unit 41. The time phase detection unit 436 operates in this process. Hereinafter, two examples of this process will be described.

  In the first processing example, the in-vivo image acquisition unit 100 acquires a new in-vivo image at a specific time phase corresponding to the timing information based on the appearance image and timing information stored in the storage unit 44. This “specific time phase” will be described. The timing information indicates the occurrence timing of the biological reaction. The specific time phase corresponds to the state of the predetermined part of the subject E (for example, the bent state of the joint) at the generation timing of the biological reaction. The specific time phase does not need to be a time phase that completely matches the state of the predetermined portion, and allows an arbitrarily set error. Further, the specific time phase does not need to be a single time phase, and may be two or more time phases.

  In this processing example, the in-vivo image acquisition unit 100 performs switching between imaging using first-intensity X-rays and imaging using second-intensity X-rays. The second intensity is lower than the first intensity. This switching is executed by controlling the parameter (described above) of the high voltage applied from the high voltage generator 14 to the X-ray generator 11. The in-vivo image acquisition unit 100 irradiates X-rays having a first intensity in a specific time phase, and irradiates X-rays having a second intensity in a time phase other than the specific time phase. Thereby, a plurality of new in-vivo images corresponding to a plurality of time phases including a specific time phase are acquired. That is, the in-vivo image acquisition unit 100 performs imaging with relatively high intensity X-rays in a specific time phase, and performs imaging with relatively low intensity X-rays in other time phases.

  The time phase detection unit 436 determines the timing for switching the X-ray intensity in such processing. In order to execute this processing, the time phase detection unit 436 is provided with a shape information generation unit 437 and a shape information determination unit 438. The shape information generation unit 437 functions as an example of a “generation unit”, and the shape information determination unit 438 functions as an example of a “determination unit”.

  A first specific example and a second specific example will be described with respect to the processing executed by the time phase detection unit 436. In both specific examples, the time phase detection unit 436 compares the newly acquired image with the appearance image acquired in the past. In the first specific example, a newly acquired in-vivo image is used, and in the second specific example, a newly acquired appearance image is used.

  A first specific example will be described. In the first specific example, the time phase detection unit 436 includes a new in-vivo image acquired by irradiating the X-ray having the second intensity (relatively low intensity), and an appearance image stored in the storage unit 44. The arrival of a specific time phase is detected by comparing.

  This process will be described more specifically. First, the shape information generation unit 437 analyzes each of the new in-vivo image acquired by irradiating the X-rays of the second intensity and the appearance image stored in the storage unit 44, and the predetermined part of the subject E Predetermined part shape information representing the shape is generated. This process includes a process similar to the process executed by the image specifying unit 434, for example. Note that the image specifying unit 434 may execute the portion related to the similar processing. As this similar process, a process for obtaining the contour, core line, angle, etc. of a predetermined part in the image (the first process example), a process for obtaining the position of the feature area in the image (the second process example), etc. There is. The predetermined part shape information in these cases is information indicating the contour shape of the predetermined part, the shape of the core wire, the angle information, or the positional relationship of the feature regions.

  The shape information determination unit 438 determines whether or not the predetermined part shape information generated from the new in-vivo image substantially matches the predetermined part shape information generated from the appearance image stored in the storage unit 44. . This determination process is, for example, the same process as the pattern matching executed by the image specifying unit 434 described above. In that case, the image specifying unit 434 may execute this process.

  The time phase detection unit 436 determines that a specific time phase has arrived when the shape information determination unit 438 determines that the predetermined part shape information substantially matches. The control unit 41 controls the in-vivo image acquisition unit 100 to switch from the second intensity to the first intensity in response to the arrival of a specific time phase detected by the time phase detection unit 436.

  A second specific example will be described. In the second specific example, the time phase detection unit 436 compares the new appearance image acquired by the appearance image acquisition unit 50 with the appearance image stored in the storage unit 44, thereby obtaining a specific time phase. Detect the arrival. Since this process replaces the in-vivo image of the first specific example with the appearance image, a detailed description is omitted. This is the end of the description of the first processing example.

  Next, a second processing example will be described. In this processing example, the in-vivo image acquisition unit 100 acquires a new in-vivo image in a predetermined period including a time phase corresponding to the timing information based on the appearance image and timing information stored in the storage unit 44.

  The difference between the first and second processing examples is the time phase that is the acquisition target of a new in-vivo image. That is, in the first processing example, new imaging is performed at a specific time phase corresponding to the stored timing information, whereas in the second processing example, not only the specific time phase but also a predetermined time including this is taken. New photography is performed during the period.

  This predetermined period will be described. The predetermined period may be a specific time phase as the start or end, or may be other than that. When a specific time phase is set as the start time, for example, a predetermined period can be set by measuring a predetermined length of time from the arrival of the specific time phase. When a specific time phase is the end, for example, information indicating a predetermined time phase that arrives before the specific time phase is included in the timing information. A period from the arrival of the predetermined time phase to the arrival of the specific time phase can be set as the predetermined period. When the specific time phase is neither the start nor the end, for example, the predetermined period can be set by determining the period before and after the specific time phase by combining the above two cases. .

  When there are a plurality of specific time phases, it is also possible to set a predetermined period between these specific time phases. The predetermined period may be composed of two or more periods. Each of these periods can be set, for example, as described above.

  Also in this processing example, as in the first processing example, the in-vivo image acquisition unit 100 performs imaging using the X-rays of the first intensity in the time phase included in the predetermined period, and at times other than the predetermined period. A plurality of new in-vivo images are acquired by performing imaging using X-rays of the second intensity in the phase.

  Regarding the switching of the X-ray intensity, the time phase detection unit 436 performs the same processing as in the first processing example. That is, when a new in-vivo image is used (corresponding to the first specific example), the time phase detection unit 436 includes a new in-vivo image acquired by irradiating the X-ray with the second intensity, and a storage unit. By comparing the appearance image stored in 44, the arrival of the time phase included in the predetermined period is detected. When a new appearance image is used (corresponding to the second specific example), the time phase detection unit 436 stores the new appearance image acquired by the appearance image acquisition unit 50 and the storage unit 44. The arrival of the time phase included in the predetermined period is detected by comparing the appearance image.

  In these processes, the shape information generation unit 437 and the shape information determination unit 438 perform the same process as in the first processing example to determine whether the predetermined part shape information based on both images substantially matches, This is performed by the time phase detection unit 436 determining that the target time phase has arrived when it is determined that they match.

  The time phase for this purpose is a time phase included in the predetermined period. The time phase for this purpose may be any time phase included in the predetermined period. For example, it is assumed that a time phase other than the start and end of a predetermined period is first detected based on the speed and direction of movement of a predetermined part and the time required for imaging and processing. In this processing example, even in such a case, it can be determined whether or not the time phase is included in the predetermined period.

  The control unit 41 controls the in-vivo image acquisition unit 100 to switch from the second intensity to the first intensity in response to the arrival of a specific time phase detected by the time phase detection unit 436.

(Storage unit, display unit, operation unit)
The storage unit 44 stores detection data, projection data, image data after reconstruction processing, and the like. The display unit 45 is configured by a display device such as an LCD (Liquid Crystal Display). The operation unit 46 is used for inputting various instructions and information to the X-ray CT apparatus 1. The operation unit 46 includes, for example, a keyboard, a mouse, a trackball, a joystick, and the like. The operation unit 46 may include a GUI (Graphical User Interface) displayed on the display unit 45.

  As described above, the operation unit 46 is used to input generation information indicating the occurrence of a biological reaction of the subject E. That is, the operation unit 46 inputs a signal as biological reaction occurrence information in response to an operation by the operator. Such an operation unit 46 functions as an “input unit”.

(Appearance image acquisition unit)
The appearance image acquisition unit 50 acquires an appearance image by imaging a predetermined part (joint part or the like) of the subject E at least at an imaging timing corresponding to input of occurrence information of a biological reaction. This shooting may be a still image shooting or a moving image shooting. The appearance image acquisition unit 50 is configured to include a digital camera and / or a digital video camera according to the shooting mode.

  In the case of still image shooting, it can be configured to execute shooting in response to input of generated information from the operation unit 46. For example, the control unit 41 that has received the generated information can be configured to control the appearance image acquisition unit 50 to perform shooting.

  It is also possible to configure so that the control unit 41 that receives the generated information performs control to output the notification information, and an operator who recognizes the notification information inputs an external image shooting trigger. The notification information is, for example, display information by the display unit 45 or audio information output by an audio output unit (not shown).

  The appearance image obtained by still image shooting corresponds to the appearance image acquired at the shooting timing corresponding to the input of the occurrence information of the biological reaction.

  One or more arbitrary number of appearance images can be obtained by such still image shooting. When acquiring two or more appearance images, one or more appearance images including those first photographed are selected as the appearance images obtained at the photographing timing corresponding to the input of the biological reaction occurrence information. It is possible. This selection process includes, for example, a process of extracting an appearance image acquired during a predetermined time or a process of extracting a predetermined number of appearance images. In addition, it is also possible to use an appearance image that has been captured between the start of still image shooting and the request for stopping shooting as the appearance image acquired at the shooting timing.

  In the case of moving image shooting, the appearance image acquisition unit 50 sequentially inputs video signals obtained by repeatedly shooting to the console device 40. Each frame obtained by this moving image shooting corresponds to an appearance image. Thereby, a plurality of appearance images along the time series are obtained.

[Operation]
The operation of the X-ray CT apparatus 1 according to this embodiment will be described. Hereinafter, first to fourth operation examples will be described. In the first operation example, imaging is performed at a time phase corresponding to the generation timing of the biological reaction. In the second operation example, imaging is performed during a predetermined period including a time phase corresponding to the generation timing of the biological reaction. In the third operation example, radiographing is performed while increasing the X-ray intensity at the time phase corresponding to the occurrence timing of the biological reaction. In the fourth operation example, imaging is performed while increasing the X-ray intensity during a predetermined period including a time phase corresponding to the generation timing of the biological reaction.

[First operation example]
In this operation example, imaging is performed at a time phase corresponding to the generation timing of the biological reaction. Hereinafter, processing for storing images and timing information will be described first (FIG. 4), and shooting based on the stored information will be described subsequently (FIG. 5). The former process and the latter process can be performed continuously (preliminary shooting and main shooting), or these processes can be performed at different dates.

(Storage of image and timing information: FIG. 4)
(S1: Acquisition of in-vivo images)
Start acquisition of multiple in-vivo images with different time phases. The acquisition of the in-vivo image is continued at least until the input of biological reaction occurrence information (S3). The process of acquiring the in-vivo image is performed as follows, for example.

  First, the subject E is placed on the top plate of the bed apparatus 30 and inserted into the opening of the gantry apparatus 10. When a predetermined scan start operation is performed, the control unit 41 sends a control signal to the scan control unit 42. Upon receiving this control signal, the scan control unit 42 controls the high voltage generation unit 14, the gantry drive unit 15, and the aperture drive unit 17 to scan a range including a predetermined part of the subject E with X-rays. The X-ray detection unit 12 detects X-rays that have passed through the subject E. The data collection unit 18 collects detection data sequentially generated from the X-ray detector 12 along with the scan. The data collection unit 18 sends the collected detection data to the preprocessing unit 431. The preprocessing unit 431 performs the above-described preprocessing on the detection data from the data collection unit 18 to generate projection data. The reconstruction processing unit 432 forms a plurality of in-vivo images having different time phases by performing a reconstruction process based on a preset reconstruction condition on the projection data.

(S2, S3: Input of biological reaction occurrence information)
When the operator recognizes the occurrence of a predetermined biological reaction (S2: YES), the operator operates the operation unit 46. Upon receiving the operation, the operation unit 46 inputs a signal as biological reaction occurrence information to the control unit 41 (S3).

(S4: Acquisition of appearance image)
Upon receiving the biological reaction occurrence information, the control unit 41 controls the appearance image acquisition unit 50 to image a predetermined part of the subject E. Or the control part 41 which received the generation | occurrence | production information of biological reaction outputs predetermined alerting | reporting information. The operator who has recognized the notification information operates the operation unit 46 to instruct acquisition of an appearance image. In response to this instruction, the appearance image acquisition unit 50 performs photographing. Thereby, an appearance image is obtained.

(S5: Identification of in-vivo images)
The image specifying unit 434 executes any one of the processes described above, so that among the plurality of in-vivo images acquired in step 1, the in-vivo body acquired substantially simultaneously with the input of biological reaction occurrence information (S 3). Identify the image.

(S6: Association and storage of in-vivo image, appearance image and timing information)
The control unit 41 associates the in-vivo image specified in step 5, the appearance image acquired in step 4, and the timing information, and stores them in the storage unit 44. This completes the operation related to the process of storing the image and the timing information.

(Photographing based on stored information: FIG. 5)
(S11: Start acquisition of appearance image)
In response to a predetermined operation for starting imaging, the appearance image acquisition unit 50 starts acquiring an appearance image of a predetermined part of the subject E. This predetermined operation may be an operation on the shooting start switch of the appearance image acquisition unit 50 or an operation on the operation unit 46 for causing the control unit 41 to execute control for causing the appearance image acquisition unit 50 to acquire an appearance image. Good. In addition, the appearance image acquired in this operation example is an image (moving image or a plurality of still images) acquired repeatedly in time series. The repetition frequency is determined according to, for example, the speed of movement of the predetermined part. As a specific example, when the joint is bent slowly, a relatively low repetition frequency is used, and when the joint is bent quickly, a relatively high repetition frequency is used.

  As the appearance image acquisition starts, the gantry driving unit 15 can be controlled to start rotation of the X-ray generation unit 11, the X-ray detection unit 12, and the like. At this stage, no X-ray is output.

(S12, S13: A specific time phase is detected)
The time phase detection unit 436 responds to timing information by comparing each appearance image (new appearance image) repeatedly acquired by the appearance image acquisition unit 50 with the appearance image stored in the storage unit 44. Detect the arrival of a specific time phase.

(S14: Start X-ray output)
In response to the arrival of a specific time phase detected by the time phase detection unit 436, the control unit 41 controls the in-vivo image acquisition unit 100 to start outputting X-rays. It should be noted that CT imaging can be started smoothly by rotating the X-ray generator 11 or the like in advance as described above.

(S15: Acquire an in-vivo image)
In response to the start of X-ray output in step 14, the in-vivo image acquisition unit 100 starts acquiring in-vivo images. The in-vivo image acquisition time (scanning time) can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

  The in-vivo image obtained by this operation example is an image depicting a time phase corresponding to the occurrence timing of a biological reaction. Moreover, according to this operation example, since it is possible to perform imaging at a timing that should be noted, that is, at the timing of occurrence of a biological reaction, it is possible to reduce the exposure dose. It is also possible to perform shooting without missing a notable timing.

[Second operation example]
In this operation example, imaging is performed during a predetermined period including a time phase corresponding to the generation timing of the biological reaction. This operation example also includes processing for storing images and timing information and photographing based on the stored information. However, the former is the same as the first operation example, and the description thereof is omitted. An example of the latter is shown in FIG.

(S21: Start appearance image acquisition)
In response to a predetermined operation for starting imaging, the appearance image acquisition unit 50 starts acquiring an appearance image of a predetermined part of the subject E. In addition, when the acquisition of the appearance image is started, the gantry driving unit 15 can be controlled to start the rotation of the X-ray generation unit 11 and the like. At this stage, no X-ray is output. The processing content of this step is the same as in the first operation example.

(S22, S23: A target time phase or a specific time phase is detected)
The time phase detection unit 436 compares each appearance image (new appearance image) repeatedly acquired by the appearance image acquisition unit 50 with the appearance image stored in the storage unit 44, thereby corresponding to the shooting period. The arrival of the target time phase included in the predetermined period or the arrival of a specific time phase corresponding to the timing information is detected. The time phase to be detected is selected according to the relationship between the specific time phase described above and a predetermined period.

(S24: Start X-ray output)
In response to the arrival of the target time phase or a specific time phase detected by the time phase detection unit 436, the control unit 41 controls the in-vivo image acquisition unit 100 to start outputting X-rays. It should be noted that CT imaging can be started smoothly by rotating the X-ray generator 11 or the like in advance as described above.

(S25: Set the shooting period)
The control unit 41 sets an imaging period in response to the target time phase or a specific time phase being detected by the time phase detection unit 436. This process is executed, for example, by a timer function of a microprocessor that measures a predetermined length of time. Note that steps 24 and 25 are started substantially simultaneously. In addition, the imaging time can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

(S26: An in-vivo image is acquired)
In response to the start of X-ray output in step 24, the in-vivo image acquisition unit 100 starts acquiring in-vivo images. This shooting is continued for the shooting period set in step 25. In other words, the control unit 41 stops the X-ray output after the imaging time has elapsed.

  The in-vivo image obtained by this operation example is an image depicting the operation of a predetermined part in a predetermined period including a time phase corresponding to the occurrence timing of a biological reaction. According to this operation example, since it is possible to perform imaging only during a predetermined period including a noticeable timing, that is, a generation timing of a biological reaction, it is possible to reduce the exposure dose. It is also possible to perform shooting without missing a notable timing.

[Third operation example]
In this operation example, imaging is performed while increasing the X-ray intensity at a specific time phase corresponding to the generation timing of the biological reaction. This operation example also includes processing for storing images and timing information and photographing based on the stored information. However, the former is the same as the first operation example, and the description thereof is omitted. An example of the latter is shown in FIG. In the following example, a specific time phase is detected using the in-vivo image, but when an appearance image is acquired in parallel with the in-vivo image, the specific time phase can be detected using the appearance image. Further, it is assumed that the first and second intensities of X-rays are determined in advance.

(S31: Start in-vivo image acquisition using low-intensity X-rays)
When a predetermined imaging start instruction is given, the control unit 41 controls the in-vivo image acquisition unit 100 to start acquiring in-vivo images using low-intensity (second intensity) X-rays. This process is executed in the same manner as in the first operation example.

(S32, S33: A specific time phase is detected)
The time phase detection unit 436 responds to timing information by comparing each appearance image (new appearance image) repeatedly acquired by the appearance image acquisition unit 50 with the appearance image stored in the storage unit 44. Detect the arrival of a specific time phase.

(S34: Switch to high-intensity X-ray)
In response to the arrival of a specific time phase detected by the time phase detection unit 436, the control unit 41 controls the in-vivo image acquisition unit 100 to determine the intensity of X-rays output from the X-ray generation unit 11. Switching from low strength (second strength) to high strength (first strength).

(S35: Start acquiring in-vivo images using high-intensity X-rays)
In response to the switching of the X-ray intensity in step 34, the in-vivo image acquisition unit 100 starts acquiring an in-vivo image using high-intensity X-rays. The in-vivo image acquisition time (scanning time) can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

  Upon the passage of a specific time phase, the control unit 41 controls the in-vivo image acquisition unit 100 to switch the X-ray intensity from high intensity to low intensity. Alternatively, the control unit 41 controls the in-vivo image acquisition unit 100 to stop the output of X-rays after the passage of a specific time phase.

  According to this operation example, a relatively high-definition image is acquired using high-intensity X-rays in a time phase corresponding to the occurrence timing of a biological reaction, and low-intensity X-rays are acquired in other time phases. A relatively low-definition image is acquired by using this. Therefore, it is possible to acquire a high-definition image at a timing to be noted, that is, a timing at which a biological reaction occurs, while reducing the exposure dose.

[Fourth operation example]
In this operation example, imaging is performed while increasing the X-ray intensity during a predetermined period including a time phase corresponding to the occurrence timing of a biological reaction. This operation example also includes processing for storing images and timing information and photographing based on the stored information. However, the former is the same as the first operation example, and the description thereof is omitted. An example of the latter is shown in FIG. In the following example, a specific time phase is detected using the in-vivo image, but when an appearance image is acquired in parallel with the in-vivo image, the specific time phase can be detected using the appearance image. Further, it is assumed that the first and second intensities of X-rays are determined in advance.

(S41: Start acquiring in-vivo images using low-intensity X-rays)
When a predetermined imaging start instruction is given, the control unit 41 controls the in-vivo image acquisition unit 100 to start acquiring in-vivo images using low-intensity (second intensity) X-rays. This process is executed in the same manner as in the first operation example.

(S42, S43: A target time phase or a specific time phase is detected)
The time phase detection unit 436 compares each appearance image (new appearance image) repeatedly acquired by the appearance image acquisition unit 50 with the appearance image stored in the storage unit 44, thereby corresponding to the shooting period. The arrival of the target time phase included in the predetermined period or the arrival of a specific time phase corresponding to the timing information is detected. The time phase to be detected is selected according to the relationship between the specific time phase described above and a predetermined period.

(S44: Switch to high-intensity X-ray)
In response to detection of a target time phase or a specific time phase by the time phase detection unit 436, the control unit 41 controls the in-vivo image acquisition unit 100 to output X-rays output from the X-ray generation unit 11. Is switched from a low strength (second strength) to a high strength (first strength).

(S45: Set the shooting period)
The control unit 41 sets an imaging period in response to the target time phase or a specific time phase being detected by the time phase detection unit 436. This process is executed in the same manner as in the second operation example. It should be noted that steps 44 and 45 are started substantially simultaneously. In addition, the imaging time can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

(S46: Start acquiring in-vivo images using high-intensity X-rays)
In response to the switching of the X-ray intensity in step 44, the in-vivo image acquisition unit 100 starts acquiring an in-vivo image using high-intensity X-rays. The in-vivo image acquisition time (scanning time) can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

  Upon the elapse of the imaging period, the control unit 41 controls the in-vivo image acquisition unit 100 to switch the X-ray intensity from high intensity to low intensity. Alternatively, the control unit 41 controls the in-vivo image acquisition unit 100 to stop the output of X-rays after the passage of the imaging period.

  According to this operation example, a relatively high-definition image is acquired using high-intensity X-rays in the time phase included in the set imaging period, and low-intensity X-rays are acquired in other time phases. A relatively low-definition image is acquired by using this. Therefore, it is possible to acquire a high-definition image in a predetermined period including a timing to be noted, that is, a generation timing of a biological reaction, while reducing the exposure amount.

[Display mode]
A method for displaying the in-vivo image and the appearance image stored as described above will be described. The display modes described below can be applied as appropriate in the second embodiment.

[First display example]
This display example relates to a case where both an in-vivo image and an appearance image are displayed.

  In response to receiving a predetermined trigger, the control unit 41 reads in-vivo images and appearance images associated with each other from the storage unit 44 and causes the display unit 45 to display them. As the display mode, only one of the read in-vivo image and appearance image may be displayed, or both may be displayed. The latter includes a case where both images are displayed side by side and a case where the other image is displayed superimposed on one image.

  According to the first display example, both images associated with each other can be browsed easily.

[Second display example]
This display example relates to a case where a display request for one of the in-vivo image and the appearance image is made. When this display example is applied, the operation unit 46 is used to instruct display of one of the in-vivo image and the appearance image associated with each other.

  The control unit 41 causes the display unit 45 to display a screen for designating an image. On this screen, for example, at least one information of patient identification information (patient ID, patient name, etc.), shooting date and time, and a reduced image (thumbnail) of the shot image is presented. The operator designates desired information among the presented information using the operation unit 46.

  The control unit 41 recognizes the designation result as an instruction to display the one image, and displays the designated image and an image associated therewith (corresponding to the other image) corresponding to the instruction. 46 is displayed.

  According to the second display example, it is possible to facilitate the browsing operation of both associated images.

[Third display example]
This display example relates to a case where an in-vivo image is displayed as a moving image (including a slide show display).

  The control unit 41 causes the storage unit 44 to store a plurality of in-vivo images acquired by the in-vivo image acquisition unit 100. And the control part 41 performs a moving image display by switching and displaying these in-vivo images on the display part 45 at predetermined time intervals in order of a time series.

  When such a moving image display is performed, the control unit 41 generates a biological reaction at the timing when the in-vivo image (one or more frames: referred to as a specific frame) specified by the image specifying unit 434 is displayed. Information to be displayed is displayed on the display unit 45. This information is called occurrence timing information. Examples of the generation timing information include character string information or image information indicating the occurrence of a biological reaction, and numerical information indicating the generation timing and generation period (continuation period) of the biological reaction.

  The timing to display the occurrence timing information is the same timing as the display of a specific frame (the first one), the same timing as the display of one of a plurality of specific frames, or the specific frame (the first one) There are timings before the display. When displaying before a specific frame, the information which counts down arrival of the display timing of a specific frame (the first of them) can be displayed. Moreover, you may make it display the information counted up by the generation | occurrence | production start of biological reaction as a trigger, or the information counted down until the completion | finish of biological reaction.

  According to the third display example, it is possible to easily grasp in what state the body is in the living body information.

[Action / Effect]
The operation and effect of the X-ray CT apparatus 1 according to this embodiment will be described.

  The X-ray CT apparatus 1 includes an in-vivo image acquisition unit 100, an operation unit 46, an appearance image acquisition unit 50, a storage unit 44, and a control unit 41. The in-vivo image acquisition unit 100 acquires a plurality of in-vivo images having different time phases by continuously or intermittently irradiating a predetermined part of the subject E with X-rays. The operation unit 46 is used to input generation information indicating the occurrence of a predetermined biological reaction of the subject E. The appearance image acquisition unit 50 acquires an appearance image by imaging a predetermined part of the subject E at least at the imaging timing corresponding to the input of the occurrence information. The control unit 41 stores the appearance image acquired at this imaging timing and timing information indicating the occurrence timing of the biological reaction in the storage unit 44 in association with each other, and stores a plurality of in-vivo images acquired by the in-vivo image acquisition unit 100. At least one of them is stored in the storage unit 44.

  The X-ray CT apparatus 1 may include an image specifying unit 434. The image specifying unit 434 specifies the in-vivo image acquired substantially simultaneously with the input of the generation information among the plurality of in-vivo images acquired by the in-vivo image acquiring unit 100. The control unit 41 stores the identified in-vivo image, the appearance image acquired at the above photographing timing, and the timing information in the storage unit 44 in association with each other.

  In a case where the appearance image acquisition unit 50 repeatedly captures predetermined portions and sequentially acquires appearance images, the image specifying unit 434 is acquired substantially simultaneously with the generation information input among the sequentially acquired appearance images. You may be comprised so that an external appearance image may be specified. The control unit 41 stores the identified appearance image in the storage unit 44 in association with the timing information as the appearance image acquired at the shooting timing.

  The X-ray CT apparatus 1 may include a time phase detection unit 436. The time phase detection unit 436 stores the new in-vivo image acquired by irradiating the relatively weak second-intensity X-ray or the new appearance image acquired by the appearance image acquisition unit 50 and the storage unit 44. The appearance of a specific time phase or a target time phase is detected by comparing the appearance image. The control unit 41 acquires a new in-vivo image or switches the X-ray intensity in response to the arrival of the time phase.

  According to such an X-ray CT apparatus 1, the storage unit associates the appearance image acquired at the imaging timing corresponding to the input of the generation information indicating the occurrence timing of the biological reaction with the timing information indicating the generation timing of the biological reaction. 44, and the in-vivo image can be stored in the storage unit 44. Therefore, the viewer of the image can recognize that the appearance image is obtained at the occurrence timing of the biological reaction.

  Also, by storing in-vivo images acquired at substantially the same time as the generation information input in association with the appearance image and timing information, it is recognized that the in-vivo images are obtained at the occurrence timing of the biological reaction. it can. Furthermore, the viewer can grasp the state of the body at the occurrence timing of the biological reaction, that is, the movement state of the body from the in-vivo image.

  Therefore, according to the X-ray CT apparatus 1, it is possible to grasp the relationship between the motion state of the body and the generation timing of the biological reaction. For example, when examining a joint part, the viewer can grasp the state of pain when the bone in the joint is in a state.

  Moreover, it is possible to reduce the exposure dose by performing new photographing using the appearance image stored in the storage unit 44.

<Second Embodiment>
In the first embodiment, the appearance image and the timing information are stored in association with each other, but in this embodiment, the in-vivo image and the timing information are stored in association with each other. In this embodiment, it is not necessary to provide an appearance image acquisition unit.

[Constitution]
A configuration example of the medical image diagnostic apparatus (X-ray CT apparatus) according to this embodiment is shown in FIG. FIG. 9 corresponds to FIG. 2 of the first embodiment. The detailed configuration of the X-ray CT apparatus 1000 conforms to, for example, FIG.

  The X-ray CT apparatus 1000 includes a control unit 41, a storage unit 44, a display unit 45, an operation unit 46, an in-vivo image acquisition unit 100, an image specifying unit 434, and a time phase detection unit 436. The time phase detection unit 436 is provided with a shape information generation unit 437 and a shape information determination unit 438. Each of these parts has the same configuration and function as the corresponding part in the first embodiment. Hereinafter, the X-ray CT apparatus 1000 will be described with reference to the contents of the first embodiment. The reference numerals follow those of the first embodiment.

  The in-vivo image acquisition unit 100 acquires a plurality of in-vivo images having different time phases by irradiating a predetermined part of the subject E with X-rays continuously or intermittently. The operation unit 46 is used to input generation information indicating the occurrence of a predetermined biological reaction of the subject E. The image specifying unit 434 specifies the in-vivo image acquired substantially simultaneously with the input of the generation information among the plurality of in-vivo images acquired by the in-vivo image acquiring unit 100. The control unit 41 stores the in-vivo image specified by the image specifying unit 434 and the timing information indicating the occurrence timing of the biological reaction in the storage unit 44 in association with each other.

  The in-vivo image acquisition unit 100 may be configured to acquire a new in-vivo image based on the in-vivo image and timing information stored in the storage unit 44. In this case, two processing examples will be described.

  In the first processing example, the in-vivo image acquisition unit 100 acquires a new in-vivo image at a specific time phase corresponding to the timing information based on the in-vivo image and timing information stored in the storage unit 44. This specific time phase has been described in the first embodiment.

  Further, in the first processing example, the in-vivo image acquisition unit 100 irradiates X-rays having the first intensity in a specific time phase, and the second intensity lower than the first intensity in a time phase other than the specific time phase. A plurality of new in-vivo images can be acquired by irradiating with intense X-rays. In other words, it is possible to perform imaging using relatively high intensity X-rays in a specific time phase, and to perform imaging using relatively low intensity X-rays in other time phases.

  In the first processing example, the time phase detection unit 436 compares the new in-vivo image acquired by irradiating the X-ray having the second intensity with the in-vivo image stored in the storage unit 44. Then, the arrival of a specific time phase is detected. In the first embodiment, the new in-vivo image or the new appearance image is compared with the appearance image stored in the storage unit 44. In this embodiment, the in-vivo images are compared with each other. Since the difference between them is only the difference in image type, the comparison process of this embodiment can be executed in the same manner as in the first embodiment.

  The configuration example of the time phase detection unit 436 includes a shape information generation unit 437 and a shape information determination unit 438. The shape information generation unit 437 analyzes each of the new in-vivo image acquired by irradiating the X-ray of the second intensity and the in-vivo image stored in the storage unit 44, and the shape of the predetermined part of the subject E The predetermined part shape information representing is generated. The shape information determination unit 438 determines whether or not the predetermined part shape information generated from the new in-vivo image substantially matches the predetermined part shape information generated from the in-vivo image stored in the storage unit 44. . The time phase detection unit 436 determines that a specific time phase has arrived when it is determined that the predetermined part shape information substantially matches.

  When the arrival of a specific time phase is detected by the time phase detection unit 436, the in-vivo image acquisition unit 100 sets the intensity of the X-ray output from the X-ray generation unit 11 to the second value under the control of the control unit 41. The intensity is switched from the intensity to the first intensity. This is the end of the description of the first processing example.

  In the second processing example, the in-vivo image acquisition unit 100 acquires a new in-vivo image in a predetermined period including a time phase corresponding to the timing information based on the in-vivo image and timing information stored in the storage unit 44. . This predetermined period has been described in the first embodiment.

  In the second operation example, the in-vivo image acquisition unit 100 emits X-rays having the first intensity in the time phase included in the predetermined period, and is lower than the first intensity in the time phase other than the predetermined period. A plurality of new in-vivo images can be acquired by irradiating the X-ray with the second intensity. That is, imaging can be performed using relatively high intensity X-rays in a time phase included in a predetermined period, and imaging can be performed using relatively low intensity X-rays in other time phases.

  In the second operation example, the time phase detection unit 436 compares the new in-vivo image acquired by irradiating the X-ray having the second intensity with the in-vivo image stored in the storage unit 44. Thus, the arrival of the time phase included in the predetermined period is detected. This processing and the configuration for executing this processing are the same as those in the first embodiment and the first processing example. When the time phase detection unit 436 detects the arrival of the time phase included in the predetermined period, the in-vivo image acquisition unit 100 controls the intensity of the X-rays output from the X-ray generation unit 11 under the control of the control unit 41. Is switched from the second intensity to the first intensity. This is the end of the description of the second processing example.

  The image specifying unit 434 will be described. In the first embodiment, three processing examples have been described, but two of them use an appearance image (analysis unit 435). In this embodiment, since an appearance image is not used, these two processing examples cannot be applied. Note that in the case of adding an appearance image acquisition unit to the configuration of this embodiment, all three processing examples can be applied as in the first embodiment.

  The image specifying unit 434 receives first input timing information indicating the input timing of the generated information using the operation unit 46 and second input timing information indicating the acquisition timing of the in-vivo image by the in-vivo image acquisition unit 100. Is done. The image specifying unit 434 specifies an in-vivo image corresponding to the second input timing information received substantially simultaneously with the first input timing information. That is, the image specifying unit 434 monitors both the input timing of the generation information and the acquisition timing of the in-vivo image, and specifies the in-vivo image acquired at a timing that substantially matches the former. The identified in-vivo image is an in-vivo image acquired substantially simultaneously with the input of the generation information among the plurality of in-vivo images acquired by the in-vivo image acquisition unit 100.

[Operation]
The operation of the X-ray CT apparatus 1000 according to this embodiment will be described. Hereinafter, first and second operation examples will be described. In the first operation example, radiographing is performed while increasing the X-ray intensity at the time phase corresponding to the occurrence timing of the biological reaction. In the second operation example, imaging is performed while increasing the X-ray intensity during a predetermined period including a time phase corresponding to the occurrence timing of the biological reaction.

[First operation example]
In this operation example, imaging is performed while increasing the X-ray intensity at a time phase corresponding to the timing of occurrence of a biological reaction. Hereinafter, processing for storing in-vivo images and timing information will be described first (FIG. 10), and imaging based on the stored information will be described subsequently (FIG. 11). The former process and the latter process can be performed continuously (preliminary shooting and main shooting), or these processes can be performed at different dates.

(In-vivo image and storage of timing information: FIG. 10)
(S51: Acquisition of in-vivo image)
Start acquisition of multiple in-vivo images with different time phases. The acquisition of the in-vivo image is continued until at least the input of biological reaction occurrence information (S53). The process for acquiring the in-vivo image is performed in the same manner as in the first embodiment.

(S52, S53: Input of occurrence information of biological reaction)
When the operator recognizes the occurrence of a predetermined biological reaction (S52: YES), the operator operates the operation unit 46. Upon receiving the operation, the operation unit 46 inputs a signal as biological reaction occurrence information to the control unit 41 (S53).

(S54: Identification of in-vivo image)
It is assumed that first input timing information indicating the generation information input timing and second input timing information indicating the in-vivo image acquisition timing by the in-vivo image acquisition unit 100 are input to the image specifying unit 434. The image specifying unit 434 specifies the in-vivo image corresponding to the second input timing information received substantially simultaneously with the first input timing information corresponding to step 53.

(S55: Association and storage of in-vivo image and timing information)
The control unit 41 associates the in-vivo image identified in step 54 with the timing information and causes the storage unit 44 to store them. This completes the operation related to the process of storing the image and the timing information.

(Photographing based on stored information: FIG. 11)
(S61: Start acquiring in-vivo images using low-intensity X-rays)
When a predetermined imaging start instruction is given, the control unit 41 controls the in-vivo image acquisition unit 100 to start acquiring in-vivo images using low-intensity (second intensity) X-rays. This process is executed in the same manner as in the first embodiment. Note that the first and second intensities of X-rays are determined in advance.

(S62, S63: A specific time phase is detected)
The time phase detection unit 436 compares timing information with each in-vivo image (new in-vivo image) repeatedly acquired using low-intensity X-rays and the in-vivo image stored in the storage unit 44. The arrival of a specific time phase corresponding to is detected.

(S64: Switch to high-intensity X-ray)
In response to the arrival of a specific time phase detected by the time phase detection unit 436, the control unit 41 controls the in-vivo image acquisition unit 100 to determine the intensity of X-rays output from the X-ray generation unit 11. Switching from low strength (second strength) to high strength (first strength).

(S65: Start acquiring in-vivo images using high-intensity X-rays)
In response to the switching of the X-ray intensity in step 64, the in-vivo image acquisition unit 100 starts acquiring the in-vivo image using high-intensity X-rays. The in-vivo image acquisition time (scanning time) can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

  Upon the passage of a specific time phase, the control unit 41 controls the in-vivo image acquisition unit 100 to switch the X-ray intensity from high intensity to low intensity. Alternatively, the control unit 41 controls the in-vivo image acquisition unit 100 to stop the output of X-rays after the passage of a specific time phase.

  According to this operation example, a relatively high-definition image is acquired using high-intensity X-rays in a time phase corresponding to the occurrence timing of a biological reaction, and low-intensity X-rays are acquired in other time phases. A relatively low-definition image is acquired by using this. Therefore, it is possible to acquire a high-definition image at a timing to be noted, that is, a timing at which a biological reaction occurs, while reducing the exposure dose.

[Second operation example]
In this operation example, imaging is performed while increasing the X-ray intensity during a predetermined period including a time phase corresponding to the occurrence timing of a biological reaction. This operation example also includes processing for storing images and timing information and photographing based on the stored information. However, the former is the same as the first operation example, and the description thereof is omitted. An example of the latter is shown in FIG. Note that the first and second intensities of X-rays are determined in advance.

(S71: Start acquiring in-vivo images using low-intensity X-rays)
When a predetermined imaging start instruction is given, the control unit 41 controls the in-vivo image acquisition unit 100 to start acquiring in-vivo images using low-intensity (second intensity) X-rays. This process is executed in the same manner as in the first operation example.

(S72, S73: A target time phase or a specific time phase is detected)
The time phase detection unit 436 compares each in-vivo image (new in-vivo image) repeatedly acquired using low-intensity X-rays with the in-vivo image stored in the storage unit 44, thereby obtaining an imaging period. The arrival of a target time phase included in a predetermined period corresponding to or the arrival of a specific time phase corresponding to the timing information is detected. The time phase to be detected is selected according to the relationship between the specific time phase described in the first embodiment and a predetermined period.

(S74: Switch to high-intensity X-ray)
In response to detection of a target time phase or a specific time phase by the time phase detection unit 436, the control unit 41 controls the in-vivo image acquisition unit 100 to output X-rays output from the X-ray generation unit 11. Is switched from a low strength (second strength) to a high strength (first strength).

(S75: Set the shooting period)
The control unit 41 sets an imaging period in response to the target time phase or a specific time phase being detected by the time phase detection unit 436. This process is executed in the same manner as in the first embodiment. Note that steps 74 and 75 are started substantially simultaneously. In addition, the imaging time can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

(S76: Start acquiring in-vivo images using high-intensity X-rays)
In response to the switching of the X-ray intensity in step 74, the in-vivo image acquisition unit 100 starts acquiring an in-vivo image using high-intensity X-rays. The in-vivo image acquisition time (scanning time) can be appropriately set based on the exposure dose, the medical treatment policy, and the like.

  Upon the elapse of the imaging period, the control unit 41 controls the in-vivo image acquisition unit 100 to switch the X-ray intensity from high intensity to low intensity. Alternatively, the control unit 41 controls the in-vivo image acquisition unit 100 to stop the output of X-rays after the passage of the imaging period.

  According to this operation example, a relatively high-definition image is acquired using high-intensity X-rays in the time phase included in the set imaging period, and low-intensity X-rays are acquired in other time phases. A relatively low-definition image is acquired by using this. Therefore, it is possible to acquire a high-definition image in a predetermined period including a timing to be noted, that is, a generation timing of a biological reaction, while reducing the exposure amount.

[Action / Effect]
According to the X-ray CT apparatus 1000 according to this embodiment, an in-vivo image acquired substantially simultaneously with the occurrence of a biological reaction and timing information indicating the occurrence timing of the biological reaction can be stored in association with each other. Therefore, the image viewer can recognize that this in-vivo image is obtained at the occurrence timing of the biological reaction. Furthermore, the viewer can grasp the state of the body at the occurrence timing of the biological reaction, that is, the state of movement of the body, from the in-vivo image. Therefore, according to the X-ray CT apparatus 1000, it is possible to grasp the relationship between the movement state of the body and the occurrence timing of the biological reaction.

  In addition, it is possible to reduce the exposure dose by performing new imaging using the in-vivo images stored in the storage unit 44.

<Modification>
A modification of the medical image diagnostic apparatus according to the embodiment will be described. Any content described in the above embodiment can be combined with each modification. Moreover, it is also possible to combine modifications. Hereinafter, the same components as those in the above embodiment will be described with the same reference numerals.

  In the above embodiment, the operator inputs that a biological reaction has occurred by using the operation unit 46. On the other hand, in this modification, the state of the subject E is monitored and the occurrence of a biological reaction is automatically detected. A configuration example of a medical image diagnostic apparatus according to this modification is shown in FIGS. FIG. 13 shows a case where this modification is applied to the first embodiment (see FIG. 2). FIG. 14 shows a case where this modification is applied to the second embodiment (see FIG. 9). A medical image diagnostic apparatus according to this modification is obtained by adding a detection unit 200 to the above embodiment.

  The detection unit 200 monitors the state of the subject E and detects the occurrence of a biological reaction, thereby inputting a signal as generation information of biological information. Biometric information to be targeted includes vocalization, facial expression, breathing, sweating, electrocardiogram, blood pressure, electromyogram, brain wave, pupil diameter, and the like. The biological reaction to be detected is, for example, a change in biological information accompanying pain. Such biological reactions are known.

  The utterance can be detected using a microphone. The detected content at this time includes the content of the utterance, the voice volume, and the like.

  The content of the utterance can be detected by, for example, a microprocessor (not shown) provided in the detection unit 200 executing a known voice recognition technique. This microprocessor determines whether or not the contents stored in advance have been uttered by analyzing the electrical signal output from the microphone. When it is determined that the content has been generated, the microprocessor inputs a generation signal to the control unit 41.

  The detection of the voice volume can be performed by, for example, a microprocessor (not shown) provided in the detection unit 200 analyzing an electrical signal output from the microphone. The microprocessor determines whether the volume is equal to or higher than a predetermined threshold based on the electrical signal. When it is determined that the volume is equal to or higher than the threshold, the microprocessor inputs a generated signal to the control unit 41.

  The facial expression and pupil diameter can be detected by photographing the patient's face and eyes and analyzing the photographed image.

  In the detection of a facial expression, a microprocessor (not shown) provided in the detection unit 200 analyzes a photographed image and expresses a characteristic point of a facial expression stored in advance (for example, a characteristic change of facial muscles accompanying the occurrence of pain). Point) and determining whether the positional relationship between these feature points matches the positional relationship corresponding to the biological reaction. When it is determined that the positional relationship corresponding to the biological reaction is satisfied, the microprocessor inputs a generation signal to the control unit 41.

  In the detection of the pupil diameter, a microprocessor (not shown) provided in the detection unit 200 analyzes the captured image to extract an image region (eye region) corresponding to the eye, and analyzes the eye region to analyze the pupil. This can be done by specifying an image region (pupil region) corresponding to and calculating the diameter of the pupil region. The microprocessor determines whether the pupil diameter is within a predetermined tolerance. When it is determined that the pupil diameter is outside the allowable range, the microprocessor inputs a generation signal to the control unit 41.

  Respiration, sweating, electrocardiogram, blood pressure, electromyogram, and electroencephalogram can be detected by using a known respiratory monitor device, sweat monitor device, electrocardiograph, blood pressure measuring device, electromyograph, and electroencephalograph, respectively. An electric signal indicating a detection result by these devices is input to a microprocessor (not shown) provided in the detection unit 200. The microprocessor determines whether a biological reaction has occurred by comparing the detection result with a predetermined threshold value. When it is determined that a biological reaction has occurred, the microprocessor inputs a generation signal to the control unit 41.

  The medical image diagnostic apparatus that has received the generated signal from the detection unit 200 identifies the in-vivo image and / or the appearance image acquired substantially simultaneously with the input timing. In addition, it is possible to change the acquisition mode of the in-vivo image and / or the appearance image in response to the input of the generated signal from the detection unit 200. For example, in response to an input of a generated signal from the detection unit 200, acquisition of an in-vivo image and / or an appearance image can be started, or the intensity of X-rays can be switched.

  According to the medical image diagnostic apparatus according to this modification, as in the above-described embodiment, it is possible to grasp the relationship between the action state of the body and the generation timing of the biological reaction. Furthermore, since the occurrence of a biological reaction can be automatically detected, the user's hand is not bothered for that purpose.

  The medical image diagnostic apparatus (first medical image diagnostic apparatus) according to the embodiment or the modified example uses the timing information, the in-vivo image and / or the appearance image as the other medical image diagnostic apparatus (this second medical image diagnostic apparatus). Can be sent to.

  The second medical image diagnostic apparatus includes an X-ray CT apparatus, an X-ray imaging apparatus, an MRI (magnetic resonance imaging) apparatus, a PET (positron tomography) apparatus, a SPECT (single photon emission tomography) apparatus, and an ultrasonic diagnosis. It can be any type of modality, such as a device.

  The second medical image diagnostic apparatus acquires the generation timing of the biological reaction based on the information received from the first medical image diagnostic apparatus, and performs imaging based on the generation timing. Thereby, also in other medical image diagnostic apparatuses, imaging can be performed at a timing corresponding to the occurrence of a biological reaction. In addition, it is possible to grasp the relationship between the movement state of the body and the generation timing of the biological reaction.

  The second medical image diagnostic apparatus superimposes the in-vivo image and / or appearance image obtained by the first medical image diagnostic apparatus and the image acquired by the second medical image diagnostic apparatus, thereby A fusion image can be displayed. A well-known method can be used for the fusion image display process including the image alignment process.

  The timing information, the in-vivo image and / or the appearance image acquired by the medical image diagnostic apparatus according to the embodiment or the modification can be used for medical actions other than the medical image diagnosis. Examples of application targets include artificial joint design, rehabilitation, and informed consent.

  In designing an artificial joint, it is possible to refer to the timing at which pain occurs or to refer to the movable range of a joint that can be grasped based on a plurality of in-vivo images. In rehabilitation, this can be accomplished while knowing how much the joint is bent and how much pain has occurred. With informed consent, it is possible to easily explain the relationship between the state of movement of the body and the timing of occurrence of a biological reaction.

  In the above embodiments and modifications, the example of the X-ray CT apparatus has been described in detail, but the same configuration can be applied to the X-ray imaging apparatus. An X-ray imaging apparatus acquires an in-vivo image by outputting X-rays from an X-ray tube, and detecting and visualizing X-rays transmitted through a subject with an X-ray detector (imaging plate). In addition to forming an image on a plane orthogonal to the direction connecting the X-ray tube and the X-ray detector, the X-ray imaging apparatus can also reconstruct a three-dimensional image from a plurality of images taken from different directions. is there. The X-ray imaging apparatus is used as an “in-vivo image acquisition unit”.

  The medical image diagnostic apparatus according to the embodiment and the modification can be used as follows. First, the first imaging is performed while bending and extending the joint without administering anesthesia to the subject, and a temporal image corresponding to the timing of occurrence of pain is acquired. This image may be an in-vivo image or an appearance image. The second imaging is performed by administering anesthesia to the subject, and the subject does not feel pain (so much). In the second imaging, it is possible to grasp the bending state of the joint by comparing the image obtained in the first imaging with the newly acquired image. Therefore, it is possible to perform imaging while maintaining a bent state in which pain is generated, or to perform imaging while slowly bending and extending a joint. Thereby, the state of the joint when pain is occurring can be examined in detail.

  In addition, when examining the same part of the subject multiple times, such as pre- and post-operative observations and follow-up observations, images of the time phase corresponding to the occurrence timing of biological reactions obtained in the past By using this, an image at the generation timing can be acquired. Thereby, it becomes possible to grasp the change in the state of the affected part in detail. Furthermore, it becomes possible to grasp in detail the relationship between the change in the state of the affected area and the biological reaction.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalents thereof.

DESCRIPTION OF SYMBOLS 1 X-ray CT apparatus 10 Base apparatus 11 X-ray generation part 12 X-ray detection part 13 Rotating body 14 High voltage generation part 15 Base drive part 16 X-ray aperture part 17 Aperture drive part 18 Data collection part 30 Bed apparatus 40 Console apparatus 41 Control unit 42 Scan control unit 43 Processing unit 431 Preprocessing unit 432 Reconstruction processing unit 433 Rendering processing unit 434 Image specifying unit 435 Analysis unit 436 Time phase detection unit 437 Shape information generation unit 438 Shape information determination unit 44 Storage unit 45 Display unit 46 Operation unit 50 Appearance image acquisition unit 100 In-vivo image acquisition unit

Claims (33)

An in-vivo image acquisition unit that continuously or intermittently irradiates a predetermined part of the subject to acquire a plurality of in-vivo images having different time phases;
An input unit for inputting occurrence information representing occurrence of a predetermined biological reaction of the subject;
An appearance image acquisition unit that acquires an appearance image by imaging the predetermined portion at least at an imaging timing corresponding to the input of the occurrence information;
A storage unit;
Control that associates the appearance image acquired at the imaging timing with timing information indicating the occurrence timing of the biological reaction in the storage unit and stores at least one of the plurality of in-vivo images in the storage unit And a medical image diagnostic apparatus. A first specifying unit that specifies an in-vivo image acquired substantially simultaneously with the input of the generation information among the in-vivo images;
The medical image diagnostic apparatus according to claim 1, wherein the control unit stores the identified in-vivo image, the appearance image acquired at the imaging timing, and the timing information in the storage unit in association with each other. The appearance image acquisition unit acquires an appearance image by photographing the predetermined part in response to the input of the occurrence information,
The medical image diagnostic apparatus according to claim 1, wherein the control unit stores the appearance image and the timing information in association with each other in the storage unit. The appearance image acquisition unit sequentially acquires appearance images by repeatedly photographing the predetermined part,
A second specifying unit for specifying an appearance image acquired substantially simultaneously with the input of the occurrence information among the sequentially acquired appearance images;
The medical device according to claim 1, wherein the control unit stores the identified appearance image in the storage unit in association with the timing information as an appearance image acquired at the photographing timing. Diagnostic imaging device.   5. The medical use according to claim 1, wherein the in-vivo image acquisition unit acquires a new in-vivo image based on an appearance image and timing information stored in the storage unit. Diagnostic imaging device.   The said in-vivo image acquisition part acquires a new in-vivo image in the specific time phase corresponding to the said timing information based on the external appearance image and timing information which were memorize | stored in the said memory | storage part. The medical image diagnostic apparatus described.   The in-vivo image acquisition unit irradiates X-rays having a first intensity in the specific time phase and X-rays having a second intensity lower than the first intensity in a time phase other than the specific time phase. The medical image diagnostic apparatus according to claim 6, wherein a plurality of new in-vivo images are acquired. By comparing the new in-vivo image acquired by irradiating the X-ray of the second intensity or the new appearance image acquired by the appearance image acquisition unit with the appearance image stored in the storage unit , Further comprising a time phase detection unit for detecting the arrival of the specific time phase,
The medical image diagnosis according to claim 7, wherein the in-vivo image acquisition unit switches from the second intensity to the first intensity in response to detection of arrival of the specific time phase. apparatus.   The in-vivo image acquisition unit acquires a new in-vivo image based on an appearance image and timing information stored in the storage unit in a predetermined period including a time phase corresponding to the timing information. 5. The medical image diagnostic apparatus according to 5.   The in-vivo image acquisition unit emits X-rays having a first intensity in a time phase included in the predetermined period, and X-rays having a second intensity lower than the first intensity in a time phase other than the predetermined period. The medical image diagnostic apparatus according to claim 9, wherein a plurality of new in-vivo images are acquired by irradiation. By comparing the new in-vivo image acquired by irradiating the second intensity of X-rays or the new appearance image acquired by the appearance image acquisition unit with the stored appearance image, the predetermined period of time A time phase detection unit for detecting the arrival of the time phase included in
The said in-vivo image acquisition part switches from said 2nd intensity | strength to said 1st intensity | strength corresponding to the arrival of the time phase included in the said predetermined period being detected. Medical diagnostic imaging device. The time phase detector is
A new in-vivo image or a new appearance image acquired by irradiating the second intensity of X-rays and an appearance image stored in the storage unit are analyzed to represent a predetermined shape representing the shape of the predetermined portion A generating unit for generating part shape information;
A determination unit that determines whether or not the predetermined part shape information generated from the new in-vivo image or the new appearance image substantially matches the predetermined part shape information generated from the appearance image stored in the storage unit Including and
The medical image diagnostic apparatus according to claim 8 or 11, wherein when it is determined that the predetermined part shape information substantially matches, the time phase has been determined. The first specific unit includes:
The appearance image is analyzed to acquire first shape information indicating the shape of the predetermined part, and each of the plurality of in-vivo images is analyzed to acquire second shape information indicating the shape of the predetermined part. Including the analysis part,
The in-vivo image corresponding to the second shape information that substantially matches the first shape information among the plurality of the acquired second shape information is specified. Medical diagnostic imaging device.   The medical image diagnostic apparatus according to claim 13, wherein the first shape information and the second shape information include contour information indicating a contour shape of a body surface at the predetermined part. The predetermined part is a joint part;
The medical image diagnostic apparatus according to claim 13, wherein the first shape information and the second shape information include angle information indicating an angle formed between bones in the joint part. The first specific unit includes:
The appearance image is analyzed to obtain first feature position information indicating a position of a predetermined feature region in the appearance image, and each of the plurality of in-vivo images is analyzed to determine a predetermined feature in the in-vivo image. Including an analysis unit that acquires second feature position information indicating a position of the region;
The medical image diagnostic apparatus according to claim 2, wherein the in-vivo image is specified based on the acquired first feature position information and the plurality of second feature position information.   The first feature position information and the second feature position information include marker position information indicating a position of an image region representing a marker attached to the body surface of the subject. The medical image diagnostic apparatus described. The first specific unit includes:
Receiving the first input timing information indicating the input timing of the occurrence information by the input unit and the second input timing information indicating the acquisition timing of the in-vivo image by the in-vivo image acquiring unit;
The medical image diagnostic apparatus according to claim 2, wherein an in-vivo image corresponding to the second input timing information input substantially simultaneously with the first input timing information is specified. An in-vivo image acquisition unit that continuously or intermittently irradiates a predetermined part of the subject to acquire a plurality of in-vivo images having different time phases;
An input unit for inputting occurrence information representing occurrence of a predetermined biological reaction of the subject;
A storage unit;
A specifying unit that specifies an in-vivo image acquired substantially simultaneously with the input of the occurrence information among the in-vivo images;
A medical image diagnostic apparatus comprising: a control unit that associates the identified in-vivo image with timing information indicating the occurrence timing of the biological reaction and stores it in the storage unit.   The medical image diagnosis apparatus according to claim 19, wherein the in-vivo image acquisition unit acquires a new in-vivo image based on the in-vivo image and timing information stored in the storage unit.   21. The in-vivo image acquisition unit acquires a new in-vivo image in a specific time phase corresponding to the timing information based on the in-vivo image and timing information stored in the storage unit. The medical image diagnostic apparatus described.   The in-vivo image acquisition unit irradiates X-rays having a first intensity in the specific time phase and X-rays having a second intensity lower than the first intensity in a time phase other than the specific time phase. The medical image diagnostic apparatus according to claim 21, wherein a plurality of new in-vivo images are acquired. Time phase detection for detecting the arrival of the specific time phase by comparing a new in-vivo image acquired by irradiating the second intensity of X-rays with an in-vivo image stored in the storage unit Further comprising
The medical image diagnosis according to claim 22, wherein the in-vivo image acquisition unit switches from the second intensity to the first intensity in response to detection of the arrival of the specific time phase. apparatus.   The in-vivo image acquisition unit acquires a new in-vivo image based on the in-vivo image and timing information stored in the storage unit in a predetermined period including a time phase corresponding to the timing information. The medical image diagnostic apparatus according to 20.   The in-vivo image acquisition unit emits X-rays having a first intensity in a time phase included in the predetermined period, and X-rays having a second intensity lower than the first intensity in a time phase other than the predetermined period. The medical image diagnostic apparatus according to claim 24, wherein a plurality of new in-vivo images are acquired by irradiation. The arrival of a time phase included in the predetermined period is detected by comparing a new in-vivo image acquired by irradiating the second intensity X-ray with an in-vivo image stored in the storage unit. It further has a time phase detector,
The said in-vivo image acquisition part switches from the said 2nd intensity | strength to the said 1st intensity | strength corresponding to the arrival of the time phase contained in the said predetermined period being detected. Medical diagnostic imaging device. The time phase detector is
Analyzing each of the new in-vivo image acquired by irradiating the second-intensity X-ray and the in-vivo image stored in the storage unit, generates predetermined part shape information representing the shape of the predetermined part. A generator,
A determination unit that determines whether or not the predetermined part shape information generated from the new in-vivo image substantially matches the predetermined part shape information generated from the in-vivo image stored in the storage unit,
27. The medical image diagnostic apparatus according to claim 23, wherein when it is determined that the predetermined part shape information substantially matches, the time phase has been determined. The specific part is:
Receiving the first input timing information indicating the input timing of the occurrence information by the input unit and the second input timing information indicating the acquisition timing of the in-vivo image by the in-vivo image acquiring unit;
The in-vivo image corresponding to the second input timing information input substantially simultaneously with the first input timing information is specified. 28. The in-vivo image according to any one of claims 19 to 27. Medical diagnostic imaging device.   The medical image diagnostic apparatus according to any one of claims 1 to 28, wherein the input unit includes an operation unit that inputs a signal as the generated information in response to an operation by an operator. .   The input unit includes a detection unit that monitors the state of the subject, detects the occurrence of the biological reaction, and inputs a signal as the generation information. The medical image diagnostic apparatus according to claim 1.   The medical image diagnostic apparatus according to claim 30, wherein the detection unit detects a change in biological information associated with pain as the biological reaction. A display unit;
The control unit causes the display unit to display a moving image based on the plurality of in-vivo images acquired by the in-vivo image acquisition unit, and information indicating the generation timing of the biological reaction based on the timing information It displays on a display part. The medical image diagnostic apparatus as described in any one of Claims 1-31 characterized by the above-mentioned. The in-vivo image acquisition unit
X-ray CT apparatus that repeatedly scans the subject with X-rays to collect data, and reconstructs the collected data to form the plurality of in-vivo images, or
The subject is irradiated with X-rays continuously or intermittently, X-rays transmitted through the subject are detected, and the plurality of in-vivo images are formed along a plane substantially orthogonal to the X-ray irradiation direction. The medical image diagnostic apparatus according to any one of claims 1 to 32, wherein the medical image diagnostic apparatus is an X-ray imaging apparatus.

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