JP2011087856A - Iontophoresis device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To administer many kinds of medicines without complicating a device configuration and without lowering permeable performances of the respective medicines. <P>SOLUTION: In an iontophoresis device, medicine additive gels 4a, 4b added with medicines different from each other are applied onto an electrode 3a, thereby the electrode 3a has medicine hold parts 5a, 5b for holding medicines different from each other on the electrode 3a. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

  The present invention relates to an iontophoresis device that administers a drug transcutaneously to a human body by applying a drug on an electrode and applying a potential to the electrode.

  In recent years, iontophoresis technology has been put into practical use in which a drug is transdermally administered to the human body by passing a weak current through the skin. In this iontophoresis technique, an iontophoresis device having an electrode provided with a drug on its surface is used in order to pass a weak current through the skin.

  When a drug is administered to the human body using an iontophoresis device, a potential is applied to the electrode while the electrode to which the drug is applied is attached to the human body. Then, an electric current flows through the human body, and the drug is transdermally administered to the human body along with this electric current. In such an iontophoresis device, one kind of drug is generally applied on one electrode, and the user selects and uses an iontophoresis device to which a desired drug is applied. (For example, refer to Patent Document 1).

JP 2006-334292 A

  As described above, in a general iontophoresis device, since one kind of drug is applied on one electrode, only a single effect can be obtained, and one treatment is performed. Even if it is necessary to administer a plurality of types of drugs to the human body to do so, it cannot be done using a single iontophoresis device.

  Therefore, it is conceivable to use as many electrodes as the number of desired drug types. However, in that case, there is a problem that the apparatus configuration is complicated and it takes time and effort to produce a plurality of electrodes, and it is difficult to administer a plurality of types of drugs to the human body.

  In addition, it is conceivable that a plurality of effects can be obtained by mixing a plurality of types of drugs and applying the mixed drugs on one electrode. However, when a plurality of medicines are mixed and applied on one electrode, the penetration performance of each medicine may be deteriorated due to the environment of the plurality of medicines mixed, and the penetration into the human body is efficiently performed. There is a problem of disappearing. For example, conditions under which the permeation performance is reduced include changes in pH and concentration due to differences in the release / penetration performance of each drug, and a decrease in release performance due to the interaction between drugs. In addition, since the penetration of drugs into the human body is different for each type of drug, the pH in the area where the mixed drug is held changes as the drug penetrates into the human body. There is a possibility that the property is impaired.

  The present invention has been made in view of the problems of the conventional techniques as described above, and reduces the permeation performance of each of a plurality of types of drugs without complicating the apparatus configuration. It is an object of the present invention to provide an iontophoresis device that can be administered without any problems.

In order to achieve the above object, the present invention provides:
An iontophoresis device that administers the drug to the human body by applying a potential to the electrode in a state where the drug is applied on the electrode and the drug is mounted so as to contact the human body,
The electrode has a plurality of drug holding parts for holding the drug,
At least two of the plurality of drug holding units hold drugs of different types.

  In the present invention configured as described above, a plurality of drug holding portions are provided on the electrode, and at least two of the plurality of drug holding portions hold different types of drugs, thereby The electrode is provided with a plurality of types of drugs in a state where they are not mixed with each other. In this state, when the surface to which the medicine is applied is attached so as to come into contact with the human body and a potential is applied to the electrodes, the medicines respectively held in the plurality of medicine holding portions are administered to the human body.

  In this way, a plurality of drug holding portions are provided on one electrode, and at least two of the plurality of drug holding portions hold different types of drugs, so that the apparatus configuration is complicated. Without being performed, and a plurality of types of drugs are administered, and at that time, a plurality of types of drugs are not mixed, so that each drug holding unit has a penetrating performance to the human body for the drug held in the drug holding unit. Optimum pH conditions that improve can be set, and the permeation performance of the drug into the human body does not decrease.

  Further, if the electrode has a first drug holding unit that holds the ionized drug in the positive electrode and a second drug holding unit that holds the ionized drug in the negative electrode, and an AC potential is applied to the electrode, A drug ionized on the positive electrode and a drug ionized on the negative electrode can be applied onto one electrode and administered to the human body.

  As described above, in the present invention, the electrode has a plurality of drug holding units that hold drugs, and at least two of the plurality of drug holding units hold drugs of different types. Different types of drugs are applied on one electrode without mixing, thereby reducing the permeation performance of multiple types of drugs without complicating the device configuration. Without administration.

  In addition, the electrode has a first drug holding unit that holds the ionized drug on the positive electrode and a second drug holding unit that holds the ionized drug on the negative electrode, and an AC potential is applied to the electrode. Can be applied to the human body by applying a drug ionized on the positive electrode and a drug ionized on the negative electrode on one electrode.

BRIEF DESCRIPTION OF THE DRAWINGS It is a figure which shows 1st Embodiment of the iontophoresis device of this invention, (a) is a top view, (b) is AA 'sectional drawing shown to (a), (c) is a circuit structure. FIG. It is a figure for demonstrating the usage method and operation | movement of the iontophoresis device shown in FIG. It is a figure which shows 2nd Embodiment of the iontophoresis device of this invention, (a) is a top view, (b) is AA 'sectional drawing shown to (a), (c) is a circuit structure. FIG. It is a figure for demonstrating the usage method of the iontophoresis device shown in FIG. 3, and its operation | movement, (a) is a figure which shows the state in which plus electric potential was applied to the electrode with which the chemical | medical agent addition gel was apply | coated, (b) ) Is a diagram showing a state in which a negative potential is applied to the electrode coated with the drug-added gel. It is a figure which shows 3rd Embodiment of the iontophoresis device of this invention, (a) is a top view, (b) is AA 'sectional drawing shown to (a), (c) is a circuit structure. FIG. It is a figure for demonstrating the usage method and operation | movement of the iontophoresis device shown in FIG.

  Embodiments of the present invention will be described below with reference to the drawings.

(First embodiment)
1A and 1B are diagrams showing a first embodiment of the iontophoresis device of the present invention, wherein FIG. 1A is a plan view, FIG. 1B is a cross-sectional view taken along line AA ′ shown in FIG. ) Is a circuit configuration diagram.

  In this embodiment, as shown in FIG. 1, two electrodes 3a and 3b made of a conductive material such as carbon or silver are placed on a base substrate 2 made of a non-conductive material such as nonwoven fabric or paper with a predetermined distance therebetween. The thin battery 6 is mounted so as to be connected to the electrodes 3a and 3b via the wiring patterns 7a and 7b. The battery 6 is connected to the wiring patterns 7a and 7b so that the electrode 3a side is a positive electrode and the electrode 3b side is a negative electrode. Further, on the electrode 3a, a drug addition gel 4a in which an ionized drug is added to the positive electrode and a drug addition gel 4b in which an ionized drug is added to the positive electrode are applied and added to the drug addition gel 4a. The medicine added and the medicine added to the medicine addition gel 4b are made of different substances. And the area | region where the chemical | medical agent addition gel 4a of the electrode 3a was apply | coated becomes the chemical | medical agent holding | maintenance part 5a, and the area | region where the chemical | medical agent addition gel 4b was apply | coated is the chemical | medical agent holding | maintenance part 5b. That is, the electrode 3a is provided with a plurality of drug holding portions 5a and 5b for holding the ionized drug on the positive electrode. A gel 8 to which no drug is added is applied on the electrode 3b. The drug-added gels 4a and 4b are set to optimal pH conditions that improve the penetration performance into the human body for the added drugs. Examples of the drug-added gels 4a and 4b include those in which a drug is added to a water-soluble polymer of PVA, polyacrylamide, polyacrylic acid, polyvinylpyrrolidone, natural polysaccharide, or the like. The base substrate 2 may be made of a synthetic resin such as natural rubber, polyurethane, polyester, or silicon resin in addition to the above-described nonwoven fabric or paper, and the electrodes 3a and 3b may be In addition to carbon and silver, platinum, gold, silver chloride, titanium, nickel, and stainless steel may be used. In addition to the drug-added gels 4a and 4b to which the drug is added as described above, the drug holding parts 5a and 5b are made of a material such as a nonwoven fabric, woven fabric, or carbon fiber to which a drug is added. It can also be used.

  Below, the usage method and operation | movement of the iontophoresis device 1 comprised as mentioned above are demonstrated.

  FIG. 2 is a diagram for explaining a method of using the iontophoresis device 1 shown in FIG. 1 and its operation.

  When the iontophoresis device 1 shown in FIG. 1 is used, as shown in FIG. 2, the drug-added gel applied on the electrode 3a with the surface side on which the electrodes 3a and 3b are formed facing the human body 9 4a, 4b and the gel 8 applied on the electrode 3b are brought into contact with the human body 9, and the iontophoresis device 1 is adhered to the human body 9 with the drug-added gels 4a, 4b and the gel 8, whereby the electrodes 3a, 3b is attached to the human body 9.

  Then, since the battery 6 is connected so that the electrode 3a side is a positive electrode and the electrode 3b side is a negative electrode, the battery 6 applies a positive potential to the electrode 3a and a negative potential to the electrode 3b, thereby A current flows from the electrode 3a to the electrode 3b through the human body 9.

  At this time, since the drugs 10a and 10b added to the drug-added gels 4a and 4b applied to the electrode 3a are respectively ionized drugs on the positive electrode, these drugs 10a and 10b are applied to the electrode 3a to which a positive potential is applied. Repels from the skin, percutaneously penetrates the human body 9 together with the current flowing through the human body 9, and is administered.

  Thus, in this embodiment, since a plurality of medicine holding portions 5a and 5b for holding medicines 10a and 10b made of different substances are provided on one electrode 3a, the apparatus configuration is complicated. In addition, the drugs 10a and 10b made of different substances are administered to a part of the human body facing the electrode 3a. At this time, the drugs 10a and 10b are not mixed with each other. An optimal environment in which the penetration performance into the human body 9 can be set, and the penetration performance of the medicines 10a and 10b into the human body 9 does not decrease.

  The drug ionized on the positive electrode added to the drug addition gels 4a and 4b includes an ammonium group, a sulfonium group, a phosphonium group, and a group in which one or more hydrogen atoms thereof are substituted with an alkyl group. A drug having

(Second Embodiment)
FIGS. 3A and 3B are diagrams showing a second embodiment of the iontophoresis device of the present invention, where FIG. 3A is a plan view, FIG. 3B is a cross-sectional view taken along line AA ′ shown in FIG. ) Is a circuit configuration diagram.

  As shown in FIG. 3, the present embodiment is different from the one shown in FIG. 1 in that the application shapes of the drug-added gels 104a and 104b on the electrode 103a are different, and the wiring is applied to apply a potential to the electrodes 103a and 103b. The difference is that the AC power supply 106 is connected via 106a and 106b. The application shape of the drug addition gels 104a and 104b is configured such that the area of the drug addition gel 104a is larger than the area of the drug addition gel 104b. In addition, an ionized drug is added to the positive electrode in the drug-added gel 104a applied on the electrode 103a, and an ionized drug is added to the negative electrode in the drug-added gel 104b. Thereby, the electrode 103a in this embodiment is provided with a first drug holding unit 105a that holds the ionized drug in the positive electrode and a second drug holding unit 105b that holds the ionized drug in the negative electrode. become.

  Below, the usage method and operation | movement of the iontophoresis device 101 comprised as mentioned above are demonstrated.

  FIG. 4 is a diagram for explaining a method of using the iontophoresis device 101 shown in FIG. 3 and its operation. FIG. 4A shows a case where a positive potential is applied to the electrode 103a coated with the drug-added gels 104a and 104b. FIG. 5B is a diagram showing a state in which a negative potential is applied to the electrode 103a coated with the drug-added gels 104a and 104b.

  When the iontophoresis device 101 shown in FIG. 3 is used, as shown in FIG. 4, the drug-added gel applied on the electrode 103a with the surface side on which the electrodes 103a and 103b are formed facing the human body 109 104a, 104b and the gel 108 applied on the electrode 103b are brought into contact with the human body 109, and the iontophoresis device 101 is adhered to the human body 109 with the drug-added gels 104a, 104b and the gel 108, whereby the electrodes 103a, 103b is attached to the human body 109.

  In this state, when a positive potential is applied to the electrode 103a and a negative potential is applied to the electrode 103b by the AC power source 106, a current flows from the electrode 103a to the electrode 103b via the human body 109.

  Then, among the drugs 110a and 110b added to the drug-added gels 104a and 104b applied to the electrode 103a, the drug 110a added to the drug-added gel 104a is a drug ionized to the positive electrode. ), The drug 110a repels from the electrode 103a to which a positive potential is applied, percutaneously penetrates the human body 109 together with the current flowing through the human body 109, and is administered.

  Further, when a negative potential is applied to the electrode 103a and a positive potential is applied to the electrode 103b by the AC power source 106, a current flows from the electrode 103b to the electrode 103a through the human body 109.

  Then, among the drugs 110a and 110b added to the drug-added gels 104a and 104b applied to the electrode 103a, respectively, the drug 110b added to the drug-added gel 104b is an ionized drug in the negative electrode. ), The drug 110b repels from the electrode 103a to which a negative potential is applied, percutaneously penetrates the human body 109 together with the current flowing through the human body 109, and is administered.

  As described above, in this embodiment, the electrode 103a is provided with the drug holding unit 105a that holds the ionized drug 110a on the positive electrode and the drug holding unit 105b that holds the ionized drug 110b on the negative electrode, and the wiring 106a. , 106b, an AC potential is applied to the electrode 103a by the AC power source 106 connected to the electrode 103a, so that the drugs to be simultaneously administered to the human body 109 are the drug 110a ionized at the positive electrode and the drug 110b ionized at the negative electrode. However, these can be administered to the human body 109 using one electrode 103a.

  In addition, as a chemical | medical agent ionized by the negative electrode added to the chemical | medical agent addition gel 104b, the chemical | medical agent in which a functional group has a carboxyl group, a phosphoric acid group, a polyphosphoric acid group, a hydroxyl group, a sulfuric acid group, a nitric acid group, and a carbonic acid group can be considered.

  Here, the reason why the areas of the drug-added gel 104a and the drug-added gel 104b applied on the electrode 103a are different from each other will be described.

  Since the drug 110a added to the drug-added gel 104a and the drug 110b added to the drug-added gel 104b are made of different substances, penetration into the human body 109 when the same potential is applied. The ease of handling is different from each other. Therefore, the area of the drug-added gel 104a to which the drug 110a that hardly penetrates the human body 109 is added is increased, and the area of the drug-added gel 104b to which the drug 110b that easily penetrates the human body 109 is added is reduced. Then, the area where the human body 109 abuts is larger in the drug addition gel 104a than in the drug addition gel 104b, so that the drug 110a added to the drug addition gel 104a is larger than the area of the drug addition gel 104a. Compared to the case where the area of the gel 104b is the same, the human body 109 is more penetrated, and the amounts of the drugs 110a and 110b penetrated into the human body 109 are equal. The dosage can be adjusted.

(Third embodiment)
5A and 5B are diagrams showing a third embodiment of the iontophoresis device of the present invention, in which FIG. 5A is a plan view, FIG. 5B is a cross-sectional view taken along line AA ′ shown in FIG. ) Is a circuit configuration diagram.

  In this embodiment, as shown in FIG. 5, a drug addition gel 204c in which an ionized drug is added to the negative electrode also on the electrode 203b to which a negative potential is applied by the battery 206, as compared with that shown in FIG. The drug-added gel 204d to which the ionized drug is added is applied to the negative electrode, and the region where the drug-added gel 204c of the electrode 203b is applied becomes the drug holding unit 205c, and the region where the drug-added gel 204d is applied is the drug. The difference is that it is a holding unit 205d. Furthermore, in this embodiment, the drug-added gel 204a and the drug-added gel 204b applied on the electrode 203a have different thicknesses, and the drug-added gel 204c and the drug-added gel 204d applied on the electrode 203b are different from each other. The thicknesses are different from each other, the drug-added gel 204a is thicker than the drug-added gel 204b, and the drug-added gel 204c is thicker than the drug-added gel 204d.

  Below, the usage method and operation | movement of the iontophoresis device 201 comprised as mentioned above are demonstrated.

  FIG. 6 is a diagram for explaining a method of using the iontophoresis device 201 shown in FIG. 5 and its operation.

  When the iontophoresis device 201 shown in FIG. 5 is used, as shown in FIG. 6, the surface on which the electrodes 203a and 203b are formed is opposed to the human body 209, and is applied on the electrodes 203a and 203b, respectively. The drug-added gels 204a to 204d are brought into contact with the human body 209, and the iontophoresis device 201 is attached to the human body 209 with the drug-added gels 204a to 204d, whereby the electrodes 203a and 203b are attached to the human body 209.

  Then, since the battery 206 is connected so that the electrode 203a side is a positive electrode and the electrode 203b side is a negative electrode, a positive potential is applied to the electrode 203a and a negative potential is applied to the electrode 203b by the battery 206. A current flows from the electrode 203a to the electrode 203b through the human body 209.

  At that time, since the drugs 210a and 210b added to the drug-added gels 204a and 204b applied to the electrode 203a are respectively ionized drugs on the positive electrode, these drugs 210a and 210b are applied to the electrode 203a to which a positive potential is applied. Repels, and permeates the human body 209 percutaneously with the current flowing through the human body 209 and is administered.

  Further, since the drugs 210c and 210d added to the drug-added gels 204c and 204d applied to the electrode 203b are respectively ionized drugs on the negative electrode, these drugs 210c and 210d are transferred from the electrode 203b to which a negative potential is applied. It repels and permeates the human body 209 percutaneously with the current flowing through the human body 209 and is administered.

  As described above, in the present embodiment, a plurality of drug holding portions 205a and 205b that hold drugs 210a and 210b made of different substances are provided on the electrode 203a to which a positive potential is applied by the battery 206, respectively. Since a plurality of medicine holding portions 205c and 205d for holding medicines 210c and 210d made of different substances are provided on the electrode 203b to which a negative potential is applied by the battery 206, the potential is applied by the battery 206. While it is possible to administer a drug consisting of a plurality of substances using both electrodes 203a and 203b, it is possible to administer a drug consisting of a plurality of substances using each of electrodes 203a and 203b.

  Here, the reason why the drug-added gel 204a and the drug-added gel 204b applied on the electrode 203a and the drug-added gel 204c and the drug-added gel 204d applied on the electrode 203b are different from each other will be described.

  Since the drug 210a added to the drug-added gel 204a and the drug 210b added to the drug-added gel 204b are made of different substances, penetration into the human body 209 when the same potential is applied. The ease of handling is different from each other. Therefore, the thickness of the drug addition gel 204a to which the drug 210a that easily penetrates into the human body 209 is added is increased, and the thickness of the drug addition gel 204b to which the drug 210b that does not easily penetrate the human body 209 is reduced. Then, since the drug-added gel 204a is thicker than the drug-added gel 204b, when a positive potential is applied to the electrode 203a, the electric resistance increases and the current does not easily flow. The added medicine 210a is less likely to penetrate the human body 209 than the case where the thickness of the medicine addition gel 204a is the same as the thickness of the medicine addition gel 204b, and the amount of penetration of the medicines 210a and 210b into the human body 209 is equal. For example, the relative dose of the drugs 210a and 210b to the human body 209 can be adjusted.

  Similarly, since the medicine 210c added to the medicine addition gel 204c and the medicine 210d added to the medicine addition gel 204d are made of different substances, the human body 209 is applied when the same potential is applied. Easiness of penetration into each other is different. Therefore, the thickness of the drug addition gel 204c to which the drug 210c that easily penetrates the human body 209 is added is increased, and the thickness of the drug addition gel 204d to which the drug 210d that does not easily penetrate the human body 209 is reduced. Then, since the drug-added gel 204c is thicker than the drug-added gel 204d, when a negative potential is applied to the electrode 203b, the electric resistance becomes large and it becomes difficult for current to flow. The added medicine 210c is less likely to penetrate the human body 209 than when the thickness of the medicine addition gel 204c is the same as the thickness of the medicine addition gel 204d, and the amount of penetration of the medicines 210c and 210d into the human body 209 is equal. For example, the relative dose of the drugs 210c and 210d to the human body 209 can be adjusted.

  In the first and third embodiments described above, a constant potential is applied to the electrodes 3a, 3b, 203a, and 203b by the batteries 6 and 206, but the electrodes 3a and 3b are used using a pulse generator. , 203a and 203b may be applied with a pulse potential. In that case, the occurrence of skin irritation and burns can be suppressed.

  Further, by combining the second and third embodiments described above, the thickness of the plurality of drug-added gels applied on the electrode to which the alternating potential is applied can be made different from each other, or applied on one electrode. It is good also as a structure which makes the area and thickness of the made medicine addition gel differ from each other.

  In the three embodiments described above, two types of drug-added gels to which drugs made of different substances are added are applied on one electrode, but are applied on one electrode. The number of substances constituting the drug-added gel is not limited to two.

  In the first and third embodiments described above, two drug holding portions are provided on one electrode. However, as shown in the second embodiment, a larger number of drug holds. It is good also as a structure which hold | maintains the chemical | medical agent from which a substance differs in at least 2 among the some chemical | medical agent holding | maintenance parts. For example, the structure which provides four chemical | medical agent holding | maintenance parts on one electrode, and hold | maintains the chemical | medical agent which consists of a mutually different substance in two chemical | medical agent holding | maintenance parts may be sufficient.

  In addition, the drugs held in the plurality of drug holding units may be the same substance or different in permeability and concentration in addition to those having different substances, and these permeability, concentration and substance may be different. Those in which at least one of them is different from each other are referred to as different types. Note that the permeability of the drug to the human body is proportional to the concentration and increases as the concentration increases, but when reaching a certain concentration, the permeability to the human body becomes constant. This is described, for example, in the document "New development of drug delivery system-Aiming for ultimate drug treatment-" supervised by Tsuneji Nagai, CM Publishing.

  It is also conceivable to provide a partition member made of an insulating material between drug-added gels applied on one electrode.

  Furthermore, it is also conceivable that the drug-added gel contains a preservative, a moisturizing agent and the like in addition to a drug that actually has a whitening effect. Examples of the wetting agent include glycols such as glycerin and ethylene glycol, diols such as 1,3-propanediol and 1,4-butanediol, sugar alcohols such as sorbitol, xylitol, mannitol, and erythritol, and urea. Examples of preservatives include parabens such as sodium benzoate and methylparaben, benzoate esters, ethyl paraoxybenzoate esters, chlorobutanol, benzyl alcohol, phenylethyl alcohol, benzalkonium chloride, cresol, dehydroacetic acid, sorbic acid, etc. It is done. Antioxidants such as sulfites, L-alcorbic acids, cysteine, thiol derivatives, etc. Electrolytes such as sodium chloride, potassium chloride, zinc chloride, aluminum chloride, ammonium chloride, hydrogen phosphate Ca, hydrogen phosphate K A phosphoric acid electrolyte such as hydrogen phosphate Na or dihydrogen phosphate Na may be contained. Furthermore, as surfactants and pH adjusters, phosphoric acid, triethanolamine, citric acid, hydrochloric acid, tartaric acid, lactic acid, succinic acid, phthalic acid, boric acid, ammonium chloride, glycine, sodium bicarbonate, sodium hydroxide , Sodium chloride, trisaminomethane, sodium carbonate, ammonia may be contained.

  Also, instead of holding a plurality of types of drugs on a plurality of drug holding parts provided on one electrode, a plurality of drug holding parts are provided on one electrode, but the same drugs are held on each other. It is also conceivable that the penetration of the medicine held in the plurality of medicine holding parts into the human body is made different by making the structures of the plurality of medicine holding parts different from each other. For example, the same medicines are held in a plurality of medicine holding parts, and the areas of the drug addition gels in the plurality of medicine holding parts are different from each other as shown in the second embodiment, or a plurality of medicines are held. By making the thickness of the drug-added gel in the part different from each other as shown in the third embodiment, the penetration degree of the drug held in the plurality of drug holding parts into the human body is made different from each other. It is possible.

1, 101, 201 Iontophylaxis device 2, 102, 202 Base substrate 3a, 3b, 103a, 103b, 203a, 203b Electrode 4a, 4b, 104a, 104b, 204a-204d Drug-added gel 5a, 5b, 105a, 105b, 205a to 205d Drug holding unit 6,206 Battery 7a, 7b, 107a, 107b, 207a, 207b Wiring pattern 8, 108 Gel 9, 109, 209 Human body 10a, 10b, 110a, 110b, 110a to 110d Drug 106 AC power supply 106a, 106b wiring

Claims (2)

An iontophoresis device that administers the drug to the human body by applying a potential to the electrode in a state where the drug is applied on the electrode and the drug is mounted so as to contact the human body,
The electrode has a plurality of drug holding parts for holding the drug,
At least two of the plurality of drug holding units are iontophoresis devices that hold drugs of different types. The iontophoresis device according to claim 1,
The electrode is
A first drug holding unit for holding a drug ionized on the positive electrode;
A second drug holding part for holding the ionized drug in the negative electrode,
An iontophoresis device in which an AC potential is applied to the electrode.

Images