JP2010269008A - Biological light measuring instrument - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To improve visual recognition property in a high density image in a biological light measuring instrument for performing high density measurement. <P>SOLUTION: The biological light measuring instrument includes: light sources 10A, 10B; a probe 2 having a plurality of probe modules 2A, 2B, where light emitting means for emitting the light from the light sources to a plurality of positions of a subject and light receiving means for detecting passage light from the subject at a plurality of positions are alternately arranged; light detecting parts 20A, 20B for outputting signals corresponding to the passage light; a processing part 31 for generating the image of the subject by using the signals from the light detecting parts; and a display part 34. The light sources and the light detecting parts include a plurality of systems corresponding to the respective probe modules. The processing part 31 generates a high density image 61 of the subject by using the whole signals obtained from the plurality of systems, and normal density images 60, 62 by using only the signals obtained from each system. The display part displays the high density image 61 and the normal density images 60, 62 simultaneously. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a biological light measurement device, and more particularly to a technique for displaying a measurement result obtained by a biological light measurement device.

  A biological light measurement device is a device that can easily measure blood circulation, hemodynamics, and hemoglobin changes in a living body with low restraint and no harm to a subject. Imaging has been realized and clinical application is expected. Thus, the biological optical measurement device is simple, non-invasive, very easy to handle, and satisfies various usage needs. On the other hand, however, it has been pointed out that the spatial resolution is low compared to the temporal resolution.

  In order to compensate for this, in the biological light measurement apparatus of Patent Document 1, the first and second probes in which the light irradiation means and the light receiving means are alternately arranged on the lattice points of the rectangular lattice are used as one light irradiation means. The light source unit and the light detection unit are provided on the first and second probes so that the other light irradiating unit or the light receiving unit is positioned between the first and second light receiving units. Corresponding to two systems, an image of the subject (double density image) is created using signals obtained from these two systems together.

JP 2007-130038 A

  According to the biological light measurement device disclosed in Patent Document 1 described above, an image created using two signals together (hereinafter referred to as “double-density image”) and a signal obtained from each system alone are used. Image (hereinafter referred to as “normal density image”) can be created. There are two types of normal density images. Among these, an image based only on the signal from the first probe is referred to as “normal density image A”, and an image based only on the signal from the second probe is referred to as “normal density image B”. It is defined as Strictly speaking, these three images—double density image, normal density image A, and normal density image B—are not images of the same measurement position because of the measurement principle. That is, when a general adult is a subject, the distance between the light irradiating means and the light receiving means is a distance corresponding to the depth from the surface of the subject to the site desired to be measured (usually 30 mm). Therefore, the measurement site of the first probe and the second probe is accurately different by 15 mm. Therefore, when comparing the position of the reaction site between the double density image and the normal density image, there is a problem that it is difficult to grasp an accurate probe relationship.

  The present invention has been made in view of the above problems, and an object of the present invention is to provide a living body light measurement device that makes it easy to grasp the positional relationship between a double-density image and a plurality of normal density images constituting the double-density image.

  In order to solve the above-described problems, a biological light measurement device according to the present invention includes a light source unit, a light irradiation unit for irradiating light from the light source unit to a plurality of positions of the subject, It has a plurality of probe modules alternately arranged with light receiving means for detecting transmitted light at a plurality of positions, and between the light irradiation means and the light receiving means of one probe module, the light irradiation means of the other probe module or An image of the subject is created using a probe arranged so that the light receiving means is positioned, a light detection unit that outputs a signal corresponding to the transmitted light detected by the light receiving unit, and a signal from the light detection unit And a display unit that displays an image of the subject, wherein the light source unit and the light detection unit include a plurality of systems corresponding to each probe module, and the processing unit includes the plurality of systems. system A high-density image of the subject using all the signals obtained from the above, and using only the signals obtained from each system, a plurality of normal density images of the subject corresponding to the system, and The display unit simultaneously displays the high-density image and at least one of the plurality of normal density images.

  According to the present invention, since a high-density image and a normal density image can be viewed simultaneously, both images can be easily compared. Therefore, it becomes easy to grasp the measurement positions of both images, and the interpretation of the images can be performed more correctly.

The block diagram which shows the whole outline | summary of the biological light measuring device of this invention External view of the biological optical measurement device of the present invention Schematic diagram showing an example of a probe Block diagram showing the configuration of the image display program The schematic diagram which shows the main screen 50 which concerns on 1st embodiment. The schematic diagram which shows the main screen 70 which concerns on 2nd embodiment. The schematic diagram which shows the main screen 80 in the initial state displayed in 3rd embodiment. Schematic diagram showing the mechanism of the superimposed image Schematic diagram showing the screen 82 after the main screen transitions Schematic diagram showing a main screen 94 displayed in the fourth embodiment

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a block diagram showing an overall outline of the biological light measurement device of the present invention, and FIG. 2 is an external view of the biological light measurement device of the present invention. This biological light measuring device 1 is a device that irradiates light from the skin surface of the head of a subject 5 and images the inside of the cerebrum with transmitted light detected on the skin surface of the head, as shown in FIG. The light source unit 10, the light detection unit 20, and the control unit 30 are mainly provided.

  The light source unit is composed of two systems of light source units 10A and 10B, each of which outputs light of a predetermined wavelength in the visible to infrared wavelength region, and the light output from the semiconductor laser 11 And an optical module 12 that applies different modulation depending on the irradiation position. In the figure, only one semiconductor laser 11 is shown per system, but a plurality of semiconductor lasers 11 are usually used to emit light of a plurality of wavelengths. The wavelength of light depends on the spectral characteristics of the substance of interest in the living body, but when measuring changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin, a plurality of wavelengths are selected from light in the wavelength range of 600 nm to 1400 nm. In the present embodiment, two semiconductor lasers 11 are used to emit light having two wavelengths of 780 nm and 830 nm, respectively. However, the value of two wavelengths is not limited to 780 nm and 830 nm, and the number of wavelengths is not limited to two wavelengths. A light emitting diode may be used instead of the semiconductor laser 11.

  The light from the semiconductor laser 11 is modulated by an oscillation unit (not shown) composed of oscillators having different oscillation frequencies. The modulation method employs analog modulation using a sine wave in this embodiment, but is not limited to this, and digital modulation using rectangular waves at different time intervals may be used. The optical module 12 includes an optical fiber coupler (not shown) that introduces light having wavelengths of 780 nm and 830 nm emitted from the respective semiconductor lasers 11 into one optical fiber (irradiation optical fiber 13).

  As shown in FIG. 2, the tip of the irradiation optical fiber 13 is fixed to the optical fiber fixing member 3 together with the tip of the detection optical fiber 21 so as to have a predetermined positional relationship. Two probe modules (a first probe module and a second probe module) corresponding to the two systems of light source units 10A and 10B are fixed to the optical fiber fixing member 3. In each probe module, the tip of the detection optical fiber 21 and the tip of the irradiation optical fiber 13 are alternately arranged. The first probe module and the second probe module are used for detecting the second probe module between the tip of the detection optical fiber 21 of the first probe module and the tip of the irradiation optical fiber 13. The tip of the optical fiber 21 is disposed and fixed to the optical fiber fixing member 3. The measuring probe 2 attached to the subject 5 is provided with a socket for receiving the tip of the optical fiber fixed to the optical fiber fixing member 3. The measurement probe 2 is attached to the head of the subject 5, and the tip of the optical fiber fixed to the optical fiber fixing member 3 is fitted into the socket, whereby the irradiation optical fiber 13 and the detection optical fiber 13 are detected on the skin surface of the head. Each tip of the optical fiber 21 can be brought into contact.

  The light detection unit includes two systems of light detection units 20A and 20B corresponding to the two systems of light source units, and is connected to the other end of each detection optical fiber 21, respectively. The two systems of light detection units 20A and 20B are a photodetector that converts light transmitted through a living body (hereinafter referred to as “transmitted light”) into an electrical signal (transmitted light intensity signal), and a discrimination that selectively detects a modulation signal. A circuit and an A / D converter 24 for A / D converting the output of the discrimination circuit are provided. In the present embodiment, a photodiode 22 is used as the photodetector. As the photodiode 22, for example, a known avalanche photodiode capable of realizing highly sensitive optical measurement is desirable. However, as the photodetector, in addition to a photodiode, a photoelectric conversion element such as a photomultiplier tube can be used. In this embodiment, a lock-in amplifier module 23 composed of a plurality of lock-in amplifiers is used as a discrimination circuit. The number of lock-in amplifiers in the lock-in amplifier module 23 is the same as or more than the sampling point of the probe.

  The light irradiated to the head from the irradiation optical fiber 13 and transmitted through the head, that is, the transmitted light is collected by the detection optical fiber 21 and detected by the photodiode 22, and then the lock-in amplifier module 23. A modulation signal corresponding to the irradiation position and wavelength is selectively detected. The modulation signal output from the lock-in amplifier module 23 is separated into transmitted light intensity signals corresponding to the wavelength and the irradiation position. The transmitted light intensity signal analog-output from the lock-in amplifier module 23 is converted into a digital signal by an A / D converter (analog-digital converter) 24, respectively.

  The control unit 30 records a transmitted light intensity signal (digital signal) input from each of the two systems of light detection units 20A and 20B, and reads out the transmitted light intensity signal at each detection position from the recording unit 32. A processing unit 31 that calculates changes in oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration change, total hemoglobin concentration, and the like, as well as graphs and distribution images representing temporal information at a plurality of measurement positions, and display of processing results And an input / output unit 33 for inputting a command by the user. The input / output unit 33 includes a monitor 34 for displaying an image. Data necessary for processing in the processing unit 31 and data before and after processing are also recorded in the recording unit 32. The transmitted light intensity signal of the recording unit 32 is data indicating the positions of the irradiation optical fiber 13 and the detection optical fiber 21 from which the signal was obtained, for example, the irradiation optical fiber 13 and the detection optical fiber from which the signal was obtained. The channel number corresponding to 21 or the coordinates on the probe 2 of the irradiation optical fiber 13 and the detection optical fiber 21 from which a signal is obtained, or the intermediate between the irradiation optical fiber 13 and the detection optical fiber 21 from which a signal is obtained. Recorded in association with any of the sampling points that are positions. Data indicating this position is used as normal position data described later.

  The control unit 30 controls measurement by the light source unit 10 and the light detection unit 20 in addition to the signal processing described above. The control is based on a command sent via the input / output unit 33. In addition to the start and end of measurement, the interval in the case of repeated measurement, and the like, switching control of the two light source units 10A and 10B and the light detection units 20A and 20B including. In order to switch and control the light source units 10A and 10B and the light detection units 20A and 20B, an ON / OFF control signal is sent to the light source units 10A and 10B to the control unit 30 and the signals from the light detection units 20A and 20B are synchronized with it. A switching means (sequencer) 35 for switching capture is provided.

  Next, the arrangement of the probe of the present invention, the irradiation optical fiber 13 and the detection optical fiber 21 will be described with reference to FIG. FIG. 3 is a schematic diagram illustrating an example of a probe. In FIG. 3A, ● (black circle) indicates the tip of the irradiation optical fiber 13 (that is, the light irradiator) of the first probe module (first system) 2A, and ○ (white circle) indicates the tip of the detection optical fiber 21 ( In other words, the symbol ◇ (white square) between them represents a sampling point. In FIG. 3 (b), ■ (black square) is the tip of the irradiation optical fiber 13 (that is, the light irradiator) of the second probe module (second system) 2B, and □ (white square) is the detection light. The tip of the fiber 13 (that is, the light receiver) is represented, and the ◆ (black square) between them represents the sampling point.

  In the probe 2 of this embodiment, as shown in FIG. 3C, two 3 × 5 probe modules 2A and 2B (FIGS. 3A and 3B) are arranged at a half pitch (adjacent light irradiators). And the light receiver are shifted in the long-side direction (one pitch) and overlapped so that the tip position of one optical fiber comes to the position of the other sampling point. That is, the arrangement density of the optical fibers in the horizontal direction (longitudinal direction) out of the two arrangement directions in the vertical and horizontal directions is twice the arrangement density in the vertical direction. The light irradiator and light receiver of the first probe module 2A are connected to the first system 10A of the light source unit and the first system 20A of the light detection unit, and the light irradiator and light receiver of the second probe module 2B are It is connected to the second system 10B of the light source unit and the second system 20B of the light detection unit. An image created from only the signal obtained from the first system 20A, that is, the signal obtained from the sampling point (の: white square) in FIG. An image created based only on the signal obtained from 20B, that is, the signal obtained from the sampling point (♦: black square) in FIG.

  FIG. 3D is an image created using both the sampling points of the probe 2 shown in FIG. 3C, that is, the signals at the sampling points of FIG. 3A and FIG. Since the density of sampling points in the long side and short side directions is double that of the normal density image A and the normal density image B, it is called a double density image. As shown in FIG. 3D, the sampling point of the normal density image A and the sampling point of the normal density image B are the irradiation optical fiber 13 (or the detection optical fiber 21) of the first probe module 2A. A positional deviation corresponding to the half width (half pitch) of the pitch with the irradiation optical fiber 13 (or the detection optical fiber 21) of the second probe module 2B occurs. In the present embodiment, the irradiation optical fiber 13 (or detection optical fiber 21) of the second probe module 2B with respect to the position of the irradiation optical fiber 13 (or detection optical fiber 21) of the first probe module 2A. The position of is shifted half pitch to the right.

  Next, the operation of the biological light measurement device 1 of this embodiment will be described. In the biological light measurement, the probe 2 is attached to the head of the subject 5, for example, the subject 5 is irradiated with light on the surface of the head while giving the subject 5 such as language generation and fingertip tapping, and the light is received by the light receiver. To detect. By giving such a problem and subtracting the signals before and after the task load, it is possible to measure the hemoglobin concentration change accompanying the brain activity. Usually, tasks are repeatedly performed after a certain period of pause, and the measurement including the period including one task load and pause is repeated as a unit of measurement, and statistical processing of signals obtained by multiple measurements is performed. I do.

  In the biological light measurement apparatus 1 of the present embodiment, the biological light measurement is performed while the control unit 30 switches the first system 10A and the second system 10B of the light source unit at a predetermined frequency (time interval). The switching time interval is not particularly limited, but is set to a time (for example, several milliseconds) in which a sufficient signal can be acquired from each light detection unit when each is turned on. When the measurement is repeated with a period including one task load and pause as a measurement unit, the measurement may be the same as the measurement repeat unit. In addition, a certain rest period may be provided so that the amount of light when one is turned on does not affect the other.

  The recording unit 32 of the biological light measurement device 1 according to the present embodiment has a normal density image A created based on the first system signal and a normal density image B created based on the second system signal. An image display program 4 for displaying a double-density image created using both the first and second system signals is stored. Next, the image display program 4 stored in the present embodiment will be described based on FIG. FIG. 4 is a block diagram showing the configuration of the image display program 4.

The image display program 4 changes the window size and display position on the display screen of the monitor 34, and a window creation unit 40 that creates a display area (hereinafter referred to as "window") whose display size and display position are variable. Reference image size data (hereinafter referred to as “positive size data”) of the window change processing unit 41, normal density image A, normal density image B and double density image, and reference position data (hereinafter referred to as “normal position”). Data ”), a normal size image / normal position data storage unit (hereinafter abbreviated as“ storage unit ”) 42, and normal density image A and normal density image B based on the positive size data in the storage unit 42. , And a size adjustment unit 43 that corrects the double-density image to a positive size, a reference point on the double-density image, the normal density image A, and the normal density image based on the normal position data. An alignment unit 44 that aligns the positions of the double density image, the normal density image A, and the normal density image B so that the points corresponding to the reference points are aligned along one direction of the display screen; And a point corresponding to the reference point of the normal density image A and the normal density image B are arranged so as to overlap at one point on the display screen of the monitor 34 and are positioned before the rearmost surface in the overlapped state. A superimposition processing unit 45 that performs a translucent process so that the image on the back side can be seen through, and a normal density image A, a normal density image B, and a type of double density image or a sampling point of each image, A guide display unit 46 that displays a guide image indicating at least one position of the light irradiation point and the light receiving point, and a display control unit 47 that performs display control of each image on the monitor 34 are provided. The storage unit 42 may use the recording unit 32. The image display program 4 is stored in the recording unit 32, and the function is realized by loading and executing the hardware (central processing unit, memory, etc.) constituting the control unit 30.
<< First Embodiment >>

  In the first embodiment, the positions and sizes of the image windows are arranged in a correct relationship and displayed side by side. Hereinafter, the first embodiment will be described with reference to FIG. FIG. 5 is a schematic diagram showing the main screen 50 of the biological light measurement device 1 according to the first embodiment. The main screen 50 includes a normal density image A60 created based on signals obtained from the first system, a double density image 61 created based on signals obtained from the first system and the second system, The normal density image B62 created based on the signals obtained from the two systems is displayed side by side in the vertical direction of the main screen 50. (Note that although three images may be displayed side by side in the horizontal direction, this embodiment will be described by taking an example in which they are displayed side by side in the vertical direction.) Furthermore, the main screen 50 displays the name and age of the subject. , Subject information area 51 for displaying subject attribute information such as gender, measurement parameter area 52 for displaying time scope, set measurement parameters, etc., and start / pause measurement as a user interface, An operation button area 53 in which an icon for inputting a command for ending, processing in the processing unit 31 is displayed. In the operation button area 53, the position of the sampling point or the like on the probe 2 is set to the positive position, and the pitch of the sampling point on the probe 2 is set to the positive size, and the normal density image A60, the double density image 61, and the normal density image B62 A “Window Adjust” icon 54 is provided for adjusting the image size and position of the image to the correct relationship.

  The window creation unit 40 creates one window for each of the subject information area 51, the measurement parameter area 52, and the operation button area 53. Further, the window creating unit 40 creates three windows for displaying each of the normal density image A60, the double density image 61, and the normal density image B62 one by one. The three windows are created to have the same size as the area surrounded by the contour lines of the normal density image A60, the double density image 61, and the normal density image B62. Therefore, in the following processing, changing the image size of the normal density image A60, the double density image 61, and the normal density image B62 is synonymous with changing each window size.

  Before displaying the initial screen of the main screen 50, the size adjustment unit 43 reads the positive size data from the storage unit 42, and adjusts the normal density image A60, the double density image 61, and the normal density image B62 to the positive size, respectively. . In the present embodiment, the actual value of the sampling point in the probe 2, that is, the actual value of the midpoint of the position of the distal end of the irradiation optical fiber 13 and the position of the distal end of the detection optical fiber 21 is used as the positive size. Further, the alignment unit 44 reads the normal position data (sampling points, channel numbers and coordinates of the irradiation optical fiber 13 and the detection optical fiber 21) from the storage unit 42, and the reference point and the normal density image of the double density image 61. The double density image 61 and the two normal density images A60 and B62 are aligned so that the points corresponding to the reference points of A60 and the normal density image B62 are aligned along one direction of the main screen 50. In the present embodiment, the double-density image 61 and the two normal density images A60 and B62 are aligned in the vertical direction of the main screen 50 using the sampling point as a reference point. This alignment is performed so that the same sampling points in each image are arranged on the vertical line of the main screen 50. The display control unit 47 displays an initial screen in which the normal density image A60, the double density image 61, and the normal density image B62 that are aligned in the positive size and the normal position are displayed in parallel in the vertical direction.

  In the present embodiment, the probe 2 of FIG. 3 is configured by shifting the second-system probe module 2B to the right by a half pitch with respect to the first-system probe module 2A. Thus, the normal density image B62 is shifted to the right by a half pitch. That is, when the double density image 61 is used as a reference, the leftmost part of the normal density image A60 matches that of the double density image 61, but the rightmost part of the normal density image A60 has a half pitch than that of the double density image 61. Shift to the left. On the other hand, the leftmost part of the normal density image B62 is shifted to the right by half a pitch from that of the double density image 61, but the rightmost part of the normal density image A60 matches that of the double density image 61. Therefore, in FIG. 5, the leftmost sampling point of the normal density image A and the leftmost sampling point of the double density image 61 are aligned so as to be positioned on the left alternate long and short dash line L of the main screen 50. Is done. Similarly, alignment is performed so that the rightmost sampling point of the double-density image 61 and the rightmost sampling point of the normal density image B are both positioned on the right-side dashed line R of the main screen 50. . 5 need not be displayed on the actual screen.

  Thereafter, the operator uses the mouse 33 to select an arbitrary one of the three windows in which the normal density image A60, the double density image 61, and the normal density image B62 are stored, and one corner of the selected window. When the image size change amount is input by dragging, the window change processing unit 41 changes the size of the selected window and the image in the window according to the change amount, and the display control unit 47 changes the size of the window and the image after the size change. Is displayed.

  When the operator selects any one of the three windows containing the normal density image A60, the double density image 61, and the normal density image B62 with the mouse and drags and moves the window, the window is changed. The processing unit 41 changes the display position on the main screen 50. Thereby, the operator can display an arbitrary image in an arbitrary size and in an arbitrary arrangement.

  When the operator wants to change the screen to the state before the change and / or movement after the size change and / or the image movement, the operator clicks the “Window Adjust” icon 54. Then, the size adjustment unit 43 reads the positive size data from the storage unit 42, and again changes the three images of the normal density image A60, the double density image 61, and the normal density image 62 to the positive size. At the same time, the alignment unit 44 reads the normal position data from the storage unit 42, and the positions of the sampling points of the three images of the normal density image A 60, the double density image 61, and the normal density image 62 are the vertical positions of the main screen 50. Align along the direction. Then, the display control unit 47 displays the three images that have been changed to the normal size side by side along the vertical direction of the main screen 50 while being aligned.

  According to the present embodiment, the sizes of the normal density image A, the double density image, and the normal density image B can be unified, and the positions of the sampling points can be aligned in the vertical direction of the main screen 50 and displayed in parallel. It becomes easy to grasp the positional relationship between these images. Furthermore, even after changing the size and arrangement of the three images arbitrarily, the three images can be unified to the positive size again, aligned and displayed in parallel, and the positional relationship between the images can be grasped. Becomes easy. Furthermore, when the present invention is also used as the maintenance mode of the apparatus, it is possible to simultaneously compare the images of the normal density measurement and the double density measurement, so that two screen modes (a high density image and a normal density image can be obtained in one measurement. ) Can be measured, and the inspection man-hours can be reduced. In addition, since the two image modes can be easily compared, an effect of increasing the possibility of finding a malfunction of the apparatus in advance can be expected.

In the present embodiment, the normal density image A, the double density image, and the normal density image B that are adjusted to the positive size on the initial screen of the main screen 50 and aligned at the normal position are displayed. Alignment and adjustment to the normal size may be performed by clicking the “Window Adjust” icon 54 without performing alignment of the normal position.
<< Second Embodiment >>

  As in the first embodiment, the second embodiment is a form in which the positions and sizes of the image windows are arranged in a correct relationship and displayed side by side. However, the normal density image A60, the double density image 61, and the normal density image 62 are displayed. When one of the image size or the display position is changed, the other two images follow and interlock with each other. Hereinafter, a second embodiment will be described with reference to FIG. FIG. 6 is a schematic diagram showing a main screen 70 according to the second embodiment.

  In the present embodiment, in one window 71 created by the window creation unit 40, the alignment unit 44 displays the normal density image A 60, the double density image 61, and the normal density image B 62 along the vertical direction of the main screen 70. Arrange the sampling points at the same position. Then, the display control unit 47 displays a window 71 containing three images.

  When the operator inputs an instruction to change the size of the window 71 with a mouse (not shown), the window change processing unit 41 sizes the window 71 and the three images displayed therein at the same magnification according to the input change amount. Make a change. When the operator selects and drags the window 71, the window change processing unit 41 rearranges the window 71 at the dragged position, but the positional relationship between the three images in the window 71 is vertical to the main screen 70. Continue to keep the sampling points aligned along the direction.

  According to the present embodiment, the display position and the size can be changed by interlocking the normal density image A60, the double density image 61, and the normal density image B62. Therefore, the three images are always displayed in a state where the positions of the sampling points are aligned along the vertical direction of the main screen 70, and the comparison can be easily performed.

In the present embodiment, the three images are stored in one window 71, and the size and position of the window 71 are changed to link the three images. However, as in the first embodiment, A total of three windows may be provided for each image, and the size and position may be changed by interlocking these three windows.
<< Third embodiment >>

  The third embodiment is an embodiment in which the normal density image A60, the double density image 61, and the normal density image B62 are superimposed and displayed. Hereinafter, the third embodiment will be described with reference to FIGS. FIG. 7 is a schematic diagram showing the main screen 80 in the initial state displayed in the third embodiment, FIG. 8 is a schematic diagram showing the mechanism of the superimposed image, and FIG. 9 is a screen 82 after the main screen transitions. It is a schematic diagram which shows.

  In the initial state, the main screen 80 of FIG. 7 according to the third embodiment inputs an instruction for superimposing and displaying the double-density image 61, the normal-density image A60, and the normal-density image B62 on the operation button area 53 “Superimpose”. Icon 81 is provided. When the operator clicks the “Superimpose” icon 81, as shown in FIG. 8, the superimposition processing unit 45 generates a normal density image A60a and a normal density image B62b that have been subjected to translucent processing. Next, the superimposing processing unit 45 positions the double-density image 61 on the backmost surface, and converts the normal density image A60a (long broken line) and the normal density image B62b (broken line) that have been subjected to the semi-transparency processing into three images. The two image sampling points are arranged and overlapped so that they coincide on the display screen. In the superimposed image 83 in which the positional accuracy of each image is relatively high, the three images substantially overlap, but in the superimposed image 84 in which the positional accuracy is relatively low, a shift occurs in the superimposed images. The display control unit 47 displays the superimposed image 83 in the main screen 80.

  The main screen 82 of FIG. 9 shows a state where the operator has transitioned after clicking the “Superimpose” icon 81. On the main screen 82, a superimposed image 83 is displayed in addition to the double density image 61, the normal density image A60, and the normal density image B62. The double-density image 61, the normal-density image A60, and the normal-density image B62 in the main screen 82 are displayed in a reduced size so as to secure a display area on the monitor of the superimposed image 83. Are aligned along the vertical direction of the screen, and the positional relationship between the three images is correctly displayed. The main screen 82 may be configured to display only the superimposed image 83. Further, a gauge for adjusting the translucency between the normal density images A60 and B61 may be provided in the operation button area 53 so that the operator can arbitrarily set the translucency. In the above description, for example, the order of images to be superimposed is the normal density image A, the normal density image B, and the double density image (the backmost image) in order from the top. However, the order may be arbitrarily set. . In addition, a combination of images to be superimposed may be arbitrarily selected. For example, when a plurality of arbitrary images are selected from the normal density image A, the normal density image B, and the double density image displayed in parallel on the main screen 80 in FIG. 7 and then the “superimpose” icon 81 is clicked, the selected image is selected. Only images may be overlaid. In this case, the unselected image and the superimposed image may be displayed by being aligned by the alignment unit 44, for example, based on the sampling point. Further, while the superimposed image is displayed by clicking the “Superimpose” icon 81, an icon for inputting an instruction to cancel the overlapping process and return to the parallel display may be displayed. Thereby, switching between superimposed display and parallel display can be performed.

According to the present embodiment, the lower image is also hidden by superimposing the three images (double density image 61, normal density image A60, and normal density image B62) on the upper image after semi-transparent processing. Can be displayed without being displayed. This makes it easier to compare the positions of the three images.
<< Fourth Embodiment >>

  In the fourth embodiment, for each of the normal density image A60, the double density image 61, and the normal density image B62, guide images indicating the positions of light emitters and light receivers (or the positions of sampling points) are displayed side by side. It is a form. Hereinafter, a fourth embodiment will be described with reference to FIG. FIG. 10 is a schematic diagram showing a main screen 94 displayed in the fourth embodiment.

  In the fourth embodiment, in the initial state of the main screen, there is provided a “Guide” icon 90 for inputting an instruction for displaying a guide image indicating the position of the light emitter and light receiver of each image in the operation button area 53. It is done. FIG. 10 shows a main screen 94 that is changed from the main screen in the initial state when the operator clicks the “Guide” icon 90. When the “Guide” icon 90 is clicked, the guide display unit 46 displays a guide image indicating the position of the light irradiator and the light receiver of each image side by side. On the main screen 94, a guide image 91 indicating the positions of the light irradiator (●) and the light receiver (◯) for obtaining the signal of the normal density image A60, and a light irradiator for obtaining the signal of the double density image 61 ( ● and ■) and a guide image 92 indicating the positions of the light receivers (◯ and □), and a guide image 93 indicating the positions of the light irradiator (■) and the light receiver (□) for obtaining the signal of the normal density image B62. Are displayed side by side on each of the normal density image A60, the double density image 61, and the normal density image B62. The alignment unit 44 is configured so that the positions of the light irradiators and light receivers of the images 91, 92, and 93 and the light irradiators and light receivers corresponding to the light irradiators and light receivers in the other images are displayed on the display screen. Align so that they are aligned on the vertical line. The alignment unit 44 includes sampling points of one of the normal density image A60, the double density image 61, and the normal density image B62, and sampling points corresponding to the above-described sampling points in the other images. Align them so that they are aligned on the vertical line of the screen. The display control unit 47 displays the aligned three images 60, 61, 62 and the corresponding guide images 91, 92, 93 side by side. The guide image of the present embodiment indicates the positions of the light irradiator and the light receiver of each image, but may indicate the position of the sampling point (that is, the intermediate point between the light irradiator and the light receiver) of each image.

  According to the present embodiment, the guide image corresponding to each image is displayed together with the three images (double density image 61, normal density image A60, and normal density image B62), making it easy to understand the type of image and the measurement site. Become.

  In the above embodiment, the three normal density images and the double density image are displayed. However, a combination of one of the normal density images and the double density image, a combination of the two normal density images, or the like. The present invention may be applied to any of the above-mentioned actual forms for any combination of images.

  In the above-described embodiment, the probe 2 includes the first probe module and the second probe module, and is configured to be able to acquire two systems of signals, so that two types of normal density images and double density (= 2) are obtained. For example, the probe 2 is configured so as to be able to acquire signals of three or more systems, and a high density image of three or four times density and three or more types of normal images are used. Even when creating a density image, the present embodiment can be applied. Furthermore, in the above embodiment, the three images are aligned along the vertical direction of the display screen, and the alignment is performed so that the sampling points of each image are aligned along the vertical direction. The direction of performing is not limited to the above.

  In the above embodiment, the normal density image is displayed in a shape with four corners cut out, and the double density image is displayed in a rectangular shape, so that the double density image and the normal density image can be identified. The normal density image and the double density image may be displayed in the same shape, for example, all rectangular shapes. In addition, the normal density image and the double density image can be identified by changing the shape of the image, changing the frame of the image, or displaying an image such as “normal density image A”, “double density image”, or “normal density image B”. You may add the name.

1: biological light measurement device, 2: probe, 2A: first probe module, 2B: second probe module, 3: optical fiber fixing member, 4: image display program, 5: subject, 10A: first system Light source unit, 10B: second system light source unit, 11: semiconductor laser, 12: optical module, 13: optical fiber for irradiation, 20A: first system light detection unit, 20B: second system light detection unit, 21: optical fiber for detection, 22: photodiode, 23: lock-in amplifier module, 24: A / D converter, 30: control unit, 31: processing unit, 32: recording unit, 33: input / output unit, 34: Monitor: 35: Sequencer, 40: Window creation unit, 41: Window change processing unit, 42: Positive size data / normal position data storage unit, 43: Size adjustment unit, 44: Position adjustment unit, 45: Heavy Processing unit 46: Guide display unit 47: Display control unit 50: Main screen 51: Subject information area 52: Measurement parameter area 53: Operation button area 54: Window Adjust icon 60: Normal density image A, 60a: Normal density image A after translucent processing, 61: Double density image, 62: Normal density image B, 62a: Normal density image B after translucent processing, 70: Main screen, 71: Window, 80: Main screen, 81: Superimpose icon, 83: Superimposed image, 84: Superposed image, 90: Guide icon, 91: Guide image, 92: Guide image, 93: Guide image, 94: Main screen

Claims (11)

A light source unit;
A plurality of probe modules in which light irradiating means for irradiating light from the light source unit to a plurality of positions of a subject and light receiving means for detecting transmitted light from the subject at a plurality of positions are alternately arranged. A probe disposed between the light irradiation means and the light receiving means of one probe module so that the light irradiation means or the light receiving means of the other probe module is positioned;
A light detection unit that outputs a signal corresponding to the transmitted light detected by the light receiving means;
A processing unit that creates an image of the subject using a signal from the light detection unit;
A display unit for displaying an image of the subject,
The light source unit and the light detection unit are composed of a plurality of systems corresponding to each probe module,
The processing unit uses a high-density image of the subject using signals obtained from the plurality of systems and a normal density of the subject corresponding to the system using a signal obtained from at least one system. Create an image, and
The display unit simultaneously displays the high-density image and the normal density image.
A biological light measurement device characterized by that. The display unit displays the high-density image and at least one of the plurality of normal density images side by side on a single display screen,
On the display screen, the high-density image and the reference point on the high-density image and the point corresponding to the reference point on the normal density image are aligned along one direction on the display screen. A positioning unit that matches the display position with the normal density image;
The living body light measuring device according to claim 1 characterized by things. The alignment unit includes a channel number corresponding to the light irradiating unit or the light receiving unit from which a signal corresponding to the transmitted light is obtained, or the light irradiating unit or the light receiving unit from which the signal corresponding to the transmitted light is obtained. Based on the coordinates on the probe or the sampling point of the intermediate position of the light irradiation means or the light receiving means, the display positions of the high density image and the normal density image are matched,
The living body light measuring device according to claim 2 characterized by things. A first image moving unit that moves an arbitrary image of the high-density image and the normal density image to an arbitrary display position on the display screen;
The alignment unit aligns the display positions of the high-density image and the normal density image after the movement,
The living body light measuring device according to claim 2 characterized by things. The display unit displays the high-density image and the normal density image after alignment by the alignment unit on an initial screen,
A second image moving unit that moves an arbitrary image of the high-density image and the normal density image to an arbitrary position on the display screen, and moves another image on the display screen in conjunction therewith; In addition,
The living body light measuring device according to claim 2 characterized by things. On the display screen of the display unit, further comprising an image size changing unit that changes an arbitrary image size of at least one of the high-density image and the normal density image.
The living body light measuring device according to claim 1 characterized by things. A size adjusting unit that adjusts again the image whose image size has been changed by the image size changing unit to a positive size that is a reference value of the image size;
The living body light measuring device according to claim 6 characterized by things. When the image size changing unit changes any one of the high-density image and the normal density image, the image size of the other image on the display screen is linked to the same size as the change magnification. Change to
The living body light measuring device according to claim 6 characterized by things. A display area having a variable display position and display size is created on the display screen of the display unit, and at least one of the reference points on the high-density image and the plurality of normal density images is displayed in the display area. A display area creating unit that arranges the display positions so that the points corresponding to the reference points are aligned along one direction in the display area;
When the display size of the display area is changed, the image size of the high-density image and the normal density image in the display area is changed in conjunction therewith, and when the display position of the display area is changed, the high-density image And a display area change processing unit that changes a display position of the high-density image and the normal density image in conjunction with the change, while maintaining a state where the normal density image and the normal density image are aligned.
The living body light measuring device according to claim 1 characterized by things. A reference point on the high-density image and a point corresponding to the reference point in at least one of the plurality of normal density images are superimposed so as to coincide at one point on the display screen of the display unit, In addition, the image processing apparatus further includes a superimposition processing unit that performs a translucent process for visualizing the image on the back surface with respect to the image positioned before the back surface in the superimposed state,
The display unit superimposes and displays the high-density image and at least one of the plurality of normal density images.
The living body light measuring device according to claim 1 characterized by things. The high-density guide image indicating the positions of all the light irradiation means and the light-receiving means of the plurality of systems is displayed in correspondence with the high-density image, and the signal used to create the normal density image is obtained. A guide display unit for displaying a normal density guide image indicating the positions of the light irradiation means and the light receiving means in correspondence with the normal density image;
The living body light measuring device according to claim 1 characterized by things.