JP2010047535A - Skin external preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin external preparation that has excellent skin safety and an inhibitory effect on skin erythema by ultraviolet light. <P>SOLUTION: The skin external preparation comprises: ascorbic acid and a derivative or salt thereof; glycyrrhizic acid and a derivative or salt thereof; a rice bran-derived component; and an essence of Gentiana lutea. The skin external preparation is useful as cosmetics in various forms such as a milky lotion, cream, lotion, skin lotion, pack, beauty lotion, detergent, makeup cosmetic, liquid medicine, ointment, powder, granule, aerosol agent, patch, cataplasma, etc., and also useful in a dosage form such as a quasi-medicine, medicine for external use, etc. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an external preparation for skin which is excellent in skin safety and has an effect of suppressing erythema of the skin caused by ultraviolet rays.

The skin is inflamed (erythema) by ultraviolet rays, and various factors are released to stimulate melanocytes. As a result, the color tone changes and blackens. This blackening is due to the overproduction of melanin produced in melanocytes and delivered to the epidermal cells. Conventionally, in order to suppress the excessive production of melanin, many searches for substances that suppress the activity of tyrosinase that purifies melanin or suppress the production of melanin have been made. In addition, a search for a substance having an effect of preventing skin irritation caused by ultraviolet rays has also been made.
As tyrosinase activity inhibitors, hydroquinone (Patent Document 1), vitamin C and its derivatives (Patent Document 2), and various plant extracts have been found to be effective (Patent Documents 3, 4 and many others). As a substance that suppresses the production of melanin, its effect has been found in various plant extracts in addition to placenta extract (Patent Document 5) (Patent Documents 6, 7, and 8).
Anti-inflammatory agents such as glycyrrhizic acid and allantoin have been proposed for the purpose of preventing inflammation caused by ultraviolet rays and improving symptoms, and skin external preparations containing these have been put on the market. Moreover, the effect is discovered also in various plant extracts (patent documents 9, 10).

JP 2004-352658 A JP-A-10-09704 JP 2008-013481 A JP 2008-056587 A Japanese Patent Publication No. 61-57291 JP 2006-182731 A JP 2007-008818 A JP 2008-156325 A JP 2005-145878 A JP 2002-138029 A

  However, the above-mentioned anti-inflammatory agents must be formulated at a considerably high concentration in order to obtain a sufficient effect. For this reason, there is a problem in terms of safety, and there is nothing that can be satisfactorily satisfied in all aspects of safety and operational effects.

  As a result of intensive studies to obtain an external preparation for skin having excellent skin safety and the effect of preventing skin erythema due to ultraviolet rays, ascorbic acid and its derivatives or salts thereof, glycyrrhizic acid and its derivatives or salts thereof, It has been found that the above-mentioned problems can be solved by combining a rice bran-derived component and a gentian extract in a topical skin preparation, and the present invention has been completed.

  ADVANTAGE OF THE INVENTION According to this invention, there is no problem in the surface of safety and the skin external preparation excellent in the effect which suppresses the erythema by an ultraviolet-ray can be provided.

  The external preparation for skin of the present invention uses ascorbic acid and a derivative thereof or a salt thereof, glycyrrhizic acid and a derivative or a salt thereof, a rice bran-derived component, and a gentian extract in combination. The essential components of the present invention will be described respectively.

  Ascorbic acid and its derivatives or salts thereof are not particularly limited as long as they can be blended into a skin external preparation. Ascorbic acid, calcium ascorbate, magnesium ascorbate, sodium ascorbate, tetrahexyldecyl ascorbate, ascorbic acid Polypeptide, methyl silanol ascorbate, sodium ascorbate sulfate, sodium isostearyl ascorbyl phosphate, sodium ascorbyl isopalmitate, chitosan ascorbic acid, ascorbyl dipalmitate, ascorbyl stearate, ascorbyl tetrahexyldecanoate, ascorbyl palmitate, palmitic Acid ascorbyl phosphate, Ascorbyl tocopheryl maleate, Ascorbyl glucoside, Ascorbylline Sodium, magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, potassium ascorbyl phosphate, zinc ascorbyl phosphate, ethyl ascorbyl, (ascorbyl / pyrrolidonecarboxylate) magnesium, (ascorbyl / tocopheryl) potassium phosphate, (ascorbyl / cholesteryl) Examples thereof include sodium phosphate. Ascorbic acid and its derivatives or salts thereof are blended in an amount of 0.001 to 5 mass% with respect to the total amount of the external preparation for skin.

  Glycyrrhizic acid and its derivatives or salts thereof are not particularly limited as long as they can be incorporated into an external preparation for skin. Allantoin glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, glycyrrhizic acid Examples include potassium, ammonium glycyrrhizinate, glycyrrhetinic acid, glyceryl glycyrrhetinate, stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, zinc glycyrrhetinate, disodium succinylglycyrrhetinate, disodium succinyloxyglycyrrhetinate, glycyrrhetinyl stearate, and the like. Glycyrrhizic acid and its derivatives or salts thereof are blended in an amount of 0.001 to 5 mass% with respect to the total amount of the external preparation for skin.

  The rice bran-derived component is not particularly limited as long as it can be blended in a skin external preparation, and an extract obtained from a rice bran by a known method using water, ethanol, 1,3-butylene glycol or the like as a solvent as it is, or Those subjected to treatments such as fractionation, purification, and hydrolysis can be used. As the rice bran derived component, a commercially available rice bran derived component can also be used. Examples of such rice bran-derived components include rice bran extract, rice bran extract (manufactured by Koei Kogyo Co., Ltd.), rice bran extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.), rice bran extract LA (manufactured by Maruzen Pharmaceutical Co., Ltd.), rice bran extract extract S (manufactured by Maruzen Pharmaceutical Co., Ltd.), Rice bran extract S (manufactured by Kojo Pharmaceutical Co., Ltd.), Oryzali Liquid S (manufactured by Ichimaru Falcos Co., Ltd.) that is a rice bran fermentation liquid, Nissan Octacosanol 12-OS (manufactured by NOF Corporation) that is a hydrolyzed rice bran extract, Regu-Age that is a hydrolyzed rice bran protein (Penta Farm Co., Ltd.) can be used. The rice bran-derived component is blended in an amount of 0.0001 to 5% by mass based on the total amount of the external preparation for skin.

  As gentian extract, root extract of gentian lutea is used. A commercially available gentian extract can be used, for example, gentian extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.), gentian extract BG-J (manufactured by Maruzen Pharmaceutical Co., Ltd.), gentian extract ET-30 (Kaei) Kogyo Co., Ltd.), Gentian Extract J (Maruzen Pharmaceutical Co., Ltd.), Falco Rex Gentiana B (Ichimaru Falcos Co., Ltd.) and the like can be used. A gentian extract is mix | blended 0.0001-5 mass% with respect to the skin external preparation whole quantity.

  The external preparation for skin of the present invention is excellent in skin safety by using ascorbic acid and its derivatives or salts thereof, glycyrrhizic acid and its derivatives or salts, rice bran derived components, and gentian extract in combination with ultraviolet rays. It has the effect of preventing skin inflammation caused by.

  In addition to the above essential components, the external preparation for skin of the present invention can be blended with components that are usually blended with external preparations for skin within the range that does not impair the effects of the present invention. The dosage form of the external preparation for skin is arbitrary, and can be provided as a solubilization system such as lotion, a dispersion system such as calamine lotion, or an emulsification system such as cream or emulsion. Further, it can be provided in various dosage forms such as an aerosol form, an ointment, and a poultice filled with a propellant.

  Specifically, various cosmetics such as emulsions, creams, lotions, lotions, packs, cosmetic liquids, cleaning agents, makeup cosmetics, etc .; liquids, ointments, powders, granules, aerosols, patches, poultices, etc. Various forms of cosmetics, quasi drugs, topical medicines, and the like can be exemplified.

  The present invention will be described using examples. First, an example of the present invention was prepared by a conventional method with the formulation shown in Table 1. Using this Example 1 and Comparative Examples 1 to 3, an erythema suppression test was performed according to the following procedure.

[Erythema suppression test]
1. Pretreatment Example or Comparative Example 24 mL was soaked in cotton 6 cm long and 8 cm wide, affixed to the backs of 4 subjects, covered and fixed with an adhesive film (Permeaid (registered trademark) manufactured by Nitto Denko), 60 Let stand for a minute, then peel off and air dry for 5 minutes.
2. Ultraviolet irradiation The application site is irradiated with 1.25 MED amount of UV-B using an ultraviolet irradiation machine (manufactured by Koyo Co., Ltd.).
3. Post-treatment As in the pre-treatment, the coated part is covered with an example or a comparative example and peeled off after 5 hours.
4). Determination of erythema After 24 hours of UV irradiation, a specialist evaluator visually determined the state of erythema, determined according to the following criteria, and the total score was taken as the erythema suppression score.
(Visual evaluation criteria)
-1: No erythema 0: Partial or slightly erythema 1: With erythema 2: With strong erythema

  As shown in Table 2, in Comparative Example 1 in which ascorbyl phosphate Mg and dipotassium glycyrrhizinate were blended, and gentian extract and hydrolyzed rice bran extract were not blended, a slight erythema inhibitory effect was observed. In Comparative Example 2 in which 0.02% by mass of gentian extract was added to Comparative Example 1, no improvement in erythema suppression effect was observed from Comparative Example 1. In Comparative Example 3 in which 0.02% by mass of the hydrolyzed rice bran extract was added to Comparative Example 1, the effect of suppressing erythema was slightly improved. On the other hand, in the examples of the present invention in which 0.01% by mass of ascorbyl phosphate Mg, dipotassium glycyrrhizinate, gentian extract and 0.01% by mass of hydrolyzed rice bran extract were added, a clear erythema inhibitory effect was observed. The synergistic improvement of the erythema suppression effect was recognized by using the gentian extract, in which erythema suppression effect was not observed, in combination with ascorbyl phosphate Mg, dipotassium glycyrrhizinate and hydrolyzed rice bran extract.

[Safety test]
When a 24-hour occlusion patch test and a guinea pig ocular mucosal irritation test were carried out using Example 1, no problems were found, indicating that Example 1 has high safety.

[Example 2] Lotion (1) Ethanol 15.0 (mass%)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 100 (5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Ascorbyl phosphate Na 1.0
(10) Dipotassium glycyrrhizinate (1% by weight aqueous solution) 5.0
(11) Hydrolyzed rice bran extract 0.01
(12) Gentian extract 0.01
Production method: (2) and (3) are dissolved in (1). Further, after sequentially adding (4) to (8), the mixture is sufficiently stirred, and (9) to (12) are added and mixed uniformly.

[Example 3] Aqueous gel (1) Acrylic-modified carboxyvinyl polymer 0.5 (mass%)
(2) The balance made into purified water 100 (3) Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
(4) Sodium hydroxide (10% by mass aqueous solution) 0.5
(5) Ethanol 10.0
(6) Methyl paraoxybenzoate 0.1
(7) Fragrance 0.1
(8) Ascorbyl phosphate Na 1.0
(9) Dipotassium glycyrrhizinate (1% by weight aqueous solution) 5.0
(10) Rice bran extract 0.01
(11) Gentian extract 0.01
Production method: (1) is added to (2) and stirred uniformly, and then the components (3) to (11) are sequentially added and mixed uniformly.

Claims (1)

  A skin external preparation containing ascorbic acid and a derivative or salt thereof, glycyrrhizic acid and a derivative or salt thereof, a rice bran-derived component, and a gentian extract.