JP2009114152A - Sebum production promoter, and skincare preparation for external use for promoting sebum production - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new sebum production promoter of high safety, and to provide a skincare preparation for external use for promoting sebum production. <P>SOLUTION: The sebum production promoter is characterized by comprising a germinated broccoli-derived ingredient as the active ingredient. The skincare preparation for external use for promoting sebum production contains the germinated broccoli-derived ingredient as the active ingredient. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a novel sebum production promoter, and more specifically, various diseases that are considered to be caused by a decrease in sebum production, such as xerosis, atopic dermatitis, dry skin, cracks, redheads, etc. The present invention relates to an agent for promoting sebum production that is useful for the prevention and treatment of septicemia and can be used for a wide range of uses such as pharmaceuticals, quasi-drugs, cosmetics, and foods and drinks.

In the skin, sebum is necessary to prevent the transpiration of moisture and maintain the smoothness of the skin, and also has the role of preventing foreign substances from entering the body. In addition, sebum is necessary for maintaining the beauty of hair in the scalp. However, when the sebum production function declines due to aging or the like, the smoothness and moisture of the skin is lost. Conventionally, as an agent for preventing or treating skin dryness due to such a decline in sebum production function, plant extracts exhibiting sebum secretion and components derived from various natural products have been used (Patent Document 1). And 2).
In addition, about the extract of germination broccoli, it is not known about the sebum secretion promotion effect (refer patent documents 3 and patent documents 4).
JP-A-7-109214 JP-A-9-176030 Japanese Patent No. 3754646 JP 2003-155221 A

This invention makes it a subject to provide the novel sebum production promoter with favorable safety | security.
Moreover, this invention makes it a subject to provide the skin external preparation which was excellent in stability and excellent in the sebum production promotion effect.
Moreover, this invention aims at providing the food / beverage products containing the said sebum production promoter.

As a result of intensive studies by the inventor to develop a novel sebum production promoter, the germinated broccoli-derived component restores the decayed sebum production function and continuously promotes the supply of oil to the skin. It has been found that it has a sebum production-promoting action, and the present invention has been completed.
That is, this invention provides the sebum production promoter characterized by making a germination broccoli origin component into an active ingredient, in order to solve the said subject.
From another point of view, according to the present invention, a skin external preparation for promoting sebum production comprising a germinated broccoli-derived component as an active ingredient; and further, a whitening agent, an antioxidant, an anti-inflammatory agent, a cell The skin external preparation for promoting the production of sebum is provided, comprising one or more medicinal agents selected from an activator and an ultraviolet light inhibitor.
From another point of view. The present invention provides a food and drink for promoting sebum production, comprising a germinated broccoli-derived component as an active ingredient.

  According to the present invention, it is useful for the prevention and treatment of various diseases that are thought to be caused by a decrease in sebum secretion, such as xeroderma, atopic dermatitis, dry skin, cracks, redheads, etc., and is safe. Can provide a sebum production promoter having good properties, and a skin external preparation for promoting sebum production such as pharmaceuticals, quasi-drugs, and cosmetics, and can further provide a food containing a sebum production promoter. .

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after.
The present invention relates to a sebum production promoter characterized by using a germinated broccoli-derived component as an active ingredient. Germinated broccoli is a sprouting body of broccoli (Brassica oleracea var. Italica) belonging to the Brassicaceae genus Brassica. The production area and cultivation method are not particularly limited. Germinated broccoli is characterized by a high content of sulforaphane compared to broccoli (growth). Moreover, indole-3-carbinol is contained in the germinated broccoli as a unique component not contained in broccoli. The germinated broccoli used in the present invention may be selected using the content of these components as an index.
The following table shows an example of the results of identifying the sulforaphane content contained in broccoli seeds, each sprout 1 to 10 days after germination of broccoli seeds, and broccoli growth bodies.

As shown in the above table, the sulforaphane contained in the germinated broccoli gradually increases after germination and reaches the maximum amount on the third day, but then gradually decreases, and in the broccoli growth body, It becomes about 1/7 of the maximum amount. The germination broccoli used in preparing the germinated broccoli-derived component used in the present invention may be any number of days after germination, as long as it is before becoming a growth body, but about 1 to 10 days after germination, more preferably 2 It is preferable to use a germinated broccoli having a high content of sulforaphane for about 5 days. Moreover, these germinating broccoli may use a thing with a fixed number of days from germination, and may use together what the days from germination differ.
Moreover, it is preferable to use a germinated broccoli having a sulforaphane content of about 32 to 160 mg / 100 g, more preferably about 100 to 150 mg / 100 g, and still more preferably about 110 to 145 mg / 100 g.
As a result of the study by the present inventors, the synthesized sulforaphane itself does not show an effect of promoting sebum production, but sprouted broccoli with a high sulforaphane content promoted sebum production, whereas in the growth body with a low sulforaphane content, Production did not change. For this reason, it is preferable to use the sulforaphane content as an index for selecting germinated broccoli that exhibits sebum production promoting effect. Various reasons such as the following (1) and (2) can be considered as the reason why the effect of promoting sebum production was not observed with the synthetic sulforaphane.
(1) In germinated broccoli, sulforaphane exists as a derivative such as a glycoside, which exerts a sebum production promoting action.
(2) The presence of sulforaphane activates other components to show sebum production promoting action.

The method for preparing the germinated broccoli-derived component used in the present invention is not particularly limited, and a part or whole plant of broccoli germination (buds, cotyledons, seeds, roots) or a dry pulverized solvent is used as a solvent. It can be obtained by extraction. In addition, a part or whole plant of broccoli germination can be used by drying and pulverizing it.
For example, when seeds of broccoli (Brassica oleracea var. Italica) belonging to the Brassica family Brassica are soaked in water at 15 ° C. to 25 ° C. and irradiated with indirect sunlight for 2 to 5 days, whole broccoli plants that have germinated ( Buds, cotyledons, seeds, roots). It is preferable to use a germinated broccoli in which buds have grown to about 10 to 50 mm. This product is dried and then pulverized to obtain germinated broccoli powder. Although this powder can be used as it is, it can also be obtained as an extract by extraction with a solvent or the like (hereinafter, a germinated broccoli-derived component is referred to as a “germinated broccoli extract” unless otherwise specified). .

It is preferable to perform a degreasing treatment before performing the extraction treatment on the germinated broccoli, since the sebum production promoting action is further improved as compared with those not subjected to the degreasing step. Specifically, the degreasing step is a step of immersing the germinated broccoli in an organic solvent and extracting and removing the lipophilic component in the germinated broccoli into the organic solvent. In the degreasing step, an organic solvent having high hydrophobicity such as n-hexane, benzol, petroleum benzine or the like is used.
Moreover, after passing through a degreasing process, before performing an extraction process, you may perform processes, such as a fine grinding | pulverization, disinfection, and sieving as needed.

The method for extracting the germinated broccoli-derived component from the germinated broccoli is not particularly limited, and examples thereof include solvent extraction and supercritical extraction. Either of these treatments or both treatments may be performed.
When extracting by solvent extraction, examples of the solvent used at this time include water, lower monohydric alcohol (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid Polyhydric alcohol (glycerin, propylene glycol, 1,3-butylene glycol, etc.), lower ester (ethyl acetate, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether, etc.), acetonitrile Etc., and one or more of them can be used. Among them, it is preferable to use water or a mixed solvent of water and a highly hydrophilic organic solvent, and ethyl alcohol is particularly preferable as such an organic solvent.

  As an example of a preferable extraction method, water-containing ethyl alcohol or 1,3-butylene glycol having a concentration of 0 to 100 vol% was used, and extracted at room temperature or heated for 1 to 10 days, followed by filtration. There is a method in which the filtrate is left to mature for an additional week and then filtered again.

  Furthermore, when extracting by the supercritical extraction method, the supercritical fluid used at that time is not particularly limited, but for example, carbon dioxide is preferably used.

  After the extraction treatment, if necessary, the extract may be subjected to steps such as decolorization and deodorization, or the solvent may be distilled off to form a powder. The germinated broccoli extract used as a sebum production promoter in the present invention has a sulforaphane content of 1.0% by mass (hereinafter simply referred to as “%” when referring to “% by mass”). ) Or more, preferably 2.0% or more, more preferably 4.0% or more (usually 15% or less). By applying the degreasing step, the content of sulforaphane contained in the extract is increased (by about 3 to 10 times). As described above, sulforaphane itself has no sebum production promoting action, but the content of sulforaphane can be used as an index when selecting the preparation conditions for the germinated broccoli extract.

  The sebum production promoter of the present invention is useful for the prevention and treatment of various diseases that are considered to be caused by a decrease in sebum production, for example, xeroderma, atopic dermatitis, dry skin, cracks, redheads, etc. . Since germinated broccoli is an active ingredient, it is highly safe and can be used in a wide range of applications such as pharmaceuticals, quasi-drugs, and cosmetics. The dosage form of the sebum production promoter of the present invention is arbitrary, and can be made into a dosage form suitable for oral administration of tablets, capsules, powders, internal liquids, fine granules, granules and the like, and a liniment. In addition, it can be made into a dosage form suitable for an external preparation for skin such as a lotion and an ointment, and any dosage form can be used.

  The present invention also relates to a skin external preparation for promoting sebum production containing a germinated broccoli extract as an active ingredient. The content of the germinated broccoli extract in the external preparation for skin is preferably 0.00001 to 5%, more preferably 0.0001 to 2% as a dry solid content. If it exists in this range, this plant extract can be mix | blended stably and a high medicinal effect can be exhibited. In addition, when the extract is used, the concentration of the extract is not limited as long as the content of dry solid content as a solute is within the above range.

  The skin external preparation for promoting sebum production of the present invention may contain other medicinal agents together with the germinated broccoli-derived component. The other medicinal agents that can be used are preferably one or more selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, and an ultraviolet inhibitor. More specifically, the following are listed. In the following examples, “derivatives” include salts that can be formed. In addition, among the specific examples listed below, materials that are recognized as having a plurality of medicinal effects may be duplicated as examples of respective medicinal effects.

(Whitening agent)
Examples of whitening agents include vitamin C and derivatives thereof (ascorbic acid glucoside, dipalmitic acid L-ascorbyl, tetraisopalmitic acid L-ascorbyl, etc., L-ascorbic acid alkyl esters, L-ascorbic acid phosphates, L-ascorbic acid Sulfate ester, etc.), arbutin, linoleic acid, placental extract, glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, yokuinin (barley) extract, koganebana (ogon) extract, seaweed extract (comb, Brown algae such as macabu, wakame, hijiki, hibamata, sujime, trolkombu, kajime, tsuruarame, chigaiso, hondawala, giant kelp; aegusa, tsunotama, sugi nori, usubanori, azasanori, matsunori, tosakamatsu, fu Red algae such as Li, Ogonori, Kamensou, Igis, Egonori; Green algae such as Chlorella, Aonori, Donariella, Chlorococcus, Anaaaosa, Kawanori, Marimo, Shiogusa, Casanori, Fujuzumo, Tamajusmo, Hitogusa, Aomido; ), Sempukuka extract, grape extract, wheat extract, tomato extract, carotenoids (carotene, lycopene, astaxanthin, etc.), agarose, oligosaccharides, hydroquinone and its derivatives, cysteine and its derivatives, Ibukitorano extract, Neubara ( Ages) extract, Ezokogi extract, pea extract, chamomile extract, keiket extract, orange extract, raspberry extract, kiwi extract, Clara extract, coffee extract, sesame oil, D Maca oil, Sesame extract, Rice extract, Rice extract, Saisin extract, Hawthorn extract, Sunpens extract, Peony extract, Shirayuri extract, Mulberry extract, Toki extract, Beech tree Extract, beech sprout extract, black currant extract, hop extract, maika (maika, hermanus) extract, mokka (bokeh) extract, yukinoshita extract, tea extract (Oolong tea, black tea, green tea, etc.), Reishi extract, microbial fermentation metabolite, soybean extract, molasses extract, Rakan fruit extract and the like. The names in parentheses are plant aliases, herbal medicine names, and the like.

  Among these whitening agents, particularly preferred are vitamin C and its derivatives, licorice extract, yakuinin (barley) extract, wheat extract, seaweed extract, and tea extract.

(Antioxidant)
Antioxidants include butylhydroxyanisole (BHA), dibutylhydroxytoluene (BHT), vitamin E and its derivatives (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α -Tocopherol, linoleic acid-dl-α-tocopherol, tocopherol and derivatives thereof such as succinic acid dl-α-tocopherol, ubiquinones, etc., vitamin A and derivatives thereof (retinol palmitate, retinol acetate, etc., and derivatives thereof, Retinal such as dehydroretinal and its derivatives), carotenoids (such as carotene, lycopene, astaxanthin), vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine di) Octanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), vitamin C and its derivatives (dipalmitate L-ascorbyl, tetraisopalmitate L-ascorbyl, etc.) L-ascorbic acid alkyl ester, L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal etc.), rutin and its derivatives, Thiotaurine, taurine, hydroquinone and derivatives thereof, histidine, catechin and derivatives thereof, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, glutathione and Derivatives thereof, gallic acid and derivatives thereof, cholesterol and derivatives thereof, superoxide dismutase, mannitol, cucumber extract, quette extract, gentian (gentian) extract, Gennosho extract, hawthorn extract, peonies extract, ginkgo biloba extract , Koganebana (Ougon) extract, carrot extract, maikaika (maikai, hamanasu) extract, sunpens (kawara ketsumei) extract, tormentilla extract, parsley extract, grape extract, button (button pi) extract, mokka (bokeh) ) Extract, Melissa extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannenrou) extract, lettuce extract, tea extract (Oolong tea, black tea, green tea, etc.), microbial fermentation metabolites, seaweed extract , Reishi extract, eggshell membrane extraction Examples include extracts, placenta extracts, and rahan fruit extracts. The names in parentheses are plant aliases, herbal medicine names, and the like.

  Among these antioxidants, particularly preferred are butylhydroxyanisole (BHA), dibutylhydroxytoluene (BHT), vitamin E and its derivatives, vitamin C and its derivatives, rutin and its derivatives, yashajitsu extract, yukinoshita Examples include extracts, micaika extract, superoxide dismutase, ginkgo biloba extract, glutathione and its derivatives, histidine, mannitol, and carotenoid.

(Anti-inflammatory agent)
Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide , Cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), aloe extract, ashitaba extract, altea extract, arnica extract, sulfur and its derivatives, nettle extract Kawamomogi) extract, Turmeric extract, Yellowfin extract, Hypericum extract, Chamomile extract, Comfrey extract, Honeysuckle extract, Watercress extract, Salvia (sage) extract, Lemoko extract, perilla extract, birch extract, elder extract, larva extract, mugwort extract, eucalyptus extract, mugwort extract, forsythia extract, chondroitin sulfate and its derivatives, zinc oxide Etc. The names in parentheses are plant aliases, herbal medicine names, and the like.

  Among these anti-inflammatory agents, particularly preferred are glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives, perilla extract, bitumen extract, comfrey extract Is mentioned.

(Cell activator)
Examples of cell activators include carotenoids (such as carotene, lycopene, astaxanthin), vitamin A and derivatives thereof (retinol such as retinol palmitate and retinol acetate; and retinals such as dehydroretinal and derivatives thereof), vitamin C and its derivatives. Derivatives (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate and L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate, L-ascorbic acid sulfate, etc.), vitamin B and its derivatives (thiamine hydrochloride) Salt, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinamide and benzyl nicotinate (Tinic acids, choline, etc.), ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, α- and γ-linolenic acid, xanthine and derivatives thereof (caffeine, etc.), amino acids and derivatives thereof (serine, glutamic acid, theanine, hydroxy) Proline, pyrrolidone carboxylic acid, etc.), docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, citric acid, lactic acid, malic acid, succinic acid, almond extract, apricot extract, ginkgo biloba extract, yellowfin ) Extract, Barley (Bakuga) extract, Kiwi extract, Cucumber extract, Shiitake extract, Japanese horse chestnut extract, Assembly extract, Soybean extract, Jujube extract, Rhizoma extract, Pepper extract, Tokachinka extract, tomato extract, garlic extract, garlic Extract, Bukuryu extract, Grape seed oil, Beech extract, Beech sprout extract, Peach extract, Eucalyptus extract, Lily extract, Lettuce extract, Lemon extract, Rosemary extract, Malt Root extract, animal-derived extract (mollusk and other mollusc extracts, shell extract, shellfish extract, fish extract, chicken crown extract, royal jelly, silk protein and its degradation products, placenta extract, serum deproteinization extraction Product, lactoferrin or its degradation product), yeast extract, microbial fermentation metabolite (derived from lactic acid bacteria, bifidobacteria, etc.), ganoderma extract and the like. The names in parentheses are plant aliases, herbal medicine names, and the like.

  Among these cell activators, particularly preferred are vitamin A and its derivatives, vitamin C and its derivatives, vitamin B and its derivatives, yeast extract, microbial fermentation metabolites (derived from lactic acid bacteria, bifidobacteria, etc.), spirits Examples include turf extract, carrot extract, malt root extract, soybean extract, camellia extract, and beech bud extract.

(UV protection agent)
Examples of UV inhibitors include paramethoxycinnamate-2-ethylhexyl, 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone and derivatives thereof (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.), titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide and the like.

  Among these UV inhibitors, particularly preferred are 2-methoxyhexyl paramethoxycinnamate, 4-tert-butyl-4′-methoxydibenzoylmethane, titanium oxide, fine particle titanium oxide, zinc oxide and Particulate zinc oxide is mentioned.

  The content of the other medicinal agent in the skin external preparation for promoting sebum production of the present invention varies depending on the type of medicinal agent, but is preferably in the following range. Within this range, when combined with germinated broccoli-derived components, it does not affect the stability of the formulation over time, and does not inhibit the sebum production-promoting effect of germinated broccoli. This is preferable.

  More specifically, the content of the whitening agent in the skin external preparation for suppressing sebum production of the present invention is preferably 0.00001 to 10%, more preferably 0.0001 to 5%. When the extract is used as an extract, it may be in this range as a dry solid content. Within this range, an excellent skin whitening effect can be obtained together with an excellent sebum production promoting effect by the germinated broccoli-derived component, and a skin external preparation having a good feeling in use can be obtained.

  The content of the antioxidant in the skin external preparation for suppressing sebum production according to the present invention is preferably 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as an extract, it may be in this range as a dry solid content. If it is this range, with the excellent sebum production promotion effect by a germinated broccoli origin component, a favorable antioxidant effect will be acquired, and also the skin external preparation with a favorable usability will be obtained.

  As content of the anti-inflammatory agent in the skin external preparation for sebum production suppression of this invention, Preferably it is 0.00001-5%, More preferably, it is the range of 0.0001-3%. When the extract is used as an extract, it may be in this range as a dry solid content. If it is this range, with the outstanding sebum production promotion effect by a germinated broccoli origin component, a favorable anti-inflammatory effect will be obtained, and also the skin external preparation with a favorable usability will be obtained.

  As content of the cell activator in the skin external preparation for sebum production suppression of this invention, Preferably it is 0.00001 to 5%, More preferably, it is 0.0001 to 3% of range. When the extract is used as an extract, it may be in this range as the dry solid content. If it is this range, with the outstanding sebum production promotion effect by a germinated broccoli origin component, a favorable cell activation effect will be obtained, and also the skin external preparation with a favorable usability will be obtained.

  The content of the ultraviolet light inhibitor in the skin external preparation for suppressing sebum production of the present invention is preferably 0.01 to 25%, more preferably 0.1 to 10%. If it is this range, with the outstanding sebum production inhibitory effect by a germinated broccoli origin component, the favorable ultraviolet-ray prevention effect will be obtained, and also the usability | use_condition for a favorable feeling of use will be obtained.

  As other medicinal agents, these whitening agents, antioxidants, anti-inflammatory agents, cell activators and ultraviolet light inhibitors can be used singly or in combination.

  The skin external preparation of the present invention can be prepared by blending germinated broccoli-derived components, which are essential components, and other medicinal components added as required, into various forms of bases in accordance with conventional methods.

  The form of the skin external preparation for promoting sebum production according to the present invention is not particularly limited, and forms of skin cosmetics such as emulsions, creams, lotions, cosmetics, packs, face wash, makeup cosmetics; shampoos, hair treatments , Hair styling agents, hair nourishing agents, hair growth agents and other hair cosmetics; and dispersions, ointments, aerosols, patches, poultices, liniments, etc.

  In addition, the skin external preparation for promoting sebum production of the present invention, as long as it does not impair the effects of the present invention, if necessary, usually used in preparations such as cosmetics, quasi-drugs, external medicines, That is, water (purified water, hot spring water, deep layer water, etc.), oil agent, surfactant, metal soap, gelling agent, powder, alcohols, water-soluble polymer, film forming agent, resin, inclusion compound, antibacterial Agents, fragrances, deodorants, salts, pH adjusters, fresheners, extracts derived from plants and microorganisms, blood circulation promoters, astringents, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins, etc. Can be added. Specific examples of suitable components include those shown below. Here, “derivatives” include salts that can be formed.

As an oil agent, it is a natural oil, a synthetic oil, or a solid oil as long as it is used for normal cosmetics as a constituent component or usability of the base, improving the feeling of use. Regardless of properties such as semi-solid or liquid, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine oils and the like can be used.
For example, hydrocarbons such as squalane, petrolatum, olive oil, castor oil, jojoba oil, mink oil, macadamia nut oil, apricot oil, persic oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, Examples include oils and fats derived from plants and animals such as almond oil, sesame oil, sesame oil, borage oil, cocoa butter, and shea butter, waxes such as beeswax, carnauba wax, candelilla wax, and gay wax.

  Surfactants are used for emulsification and solubilization of oils and the like, and anionic, cationic, nonionic and amphoteric active agents can be used.

  The metal soap is a metal salt other than an alkali salt such as a fatty acid, and examples thereof include aluminum stearate, magnesium stearate, and zinc laurate.

  Gelling agents are used to improve the stability and usability of the system, and the feeling of use. Amino acid derivatives such as N-lauroyl-L-glutamic acid, dextrin fatty acid esters such as dextrin palmitate, sucrose fatty acid esters, Examples include organically modified clay minerals.

  The powder is mainly used for various purposes such as coloring in makeup cosmetics, hiding skin, or improving the feeling of use, and if it is used in normal cosmetics, its shape (spherical, needle-like, plate , Etc.), particle diameter (smoke, fine particles, pigment grade, etc.) and particle structure (porous, non-porous, etc.) can be used. For example, as the inorganic powder, barium sulfate, calcium carbonate, talc, mica, synthetic mica, mica, kaolin, sericite, silicic acid, anhydrous silicic acid, magnesium aluminum silicate, ceramic powder, boron nitride and the like can be mentioned, Examples of organic powders include polyester powder, polyethylene powder, polystyrene powder, nylon powder, lauroyl lysine, and colored pigments include inorganic pigments such as iron oxide, carbon black, chromium oxide, bitumen, and ultramarine blue, and tar-based pigments. Examples include pearl pigments and natural pigment lakes. Pearl pigments include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scales. Foil, titanium oxide-coated colored mica, etc. Other tar pigments, natural pigments such as carminic acid. These powders may be combined, or surface treatment may be performed with an oil agent, silicone, or fluorine compound.

  Examples of alcohols include lower alcohols such as ethanol and isopropanol, glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol.

The water-soluble polymer is used for stabilizing the system, improving the usability and the feeling of use, and is also used for obtaining a moisturizing effect. Specific examples of water-soluble polymers include plant polymers such as carrageenan, pectin, agar, locust bean gum, microbial polymers such as xanthan gum, animal polymers such as casein and gelatin, and starch polymers such as starch. Cellulose polymers such as methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxypropylcellulose, crystalline cellulose, alginic acid polymers such as sodium alginate, vinyl polymers such as carboxyvinyl polymer, polyoxyethylene polymers, polyoxyethylene Examples thereof include polyoxypropylene copolymer-based polymers, acrylic polymers such as sodium polyacrylate, and inorganic water-soluble polymers such as bentonite and hectorite.
Also included are film forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone.

  Examples of humectants include proteins such as glycerin, 1,3-butylene glycol, collagen, elastin, and keratin, derivatives thereof, hydrolysates thereof, salts thereof, mucopolysaccharides such as hyaluronic acid, chondroitin sulfate, and derivatives thereof, and their Amino acids such as salts, histidine, serine, glycine, theanine, aspartic acid, arginine and derivatives thereof, and salts thereof, sorbitol, erythritol, trehalose, inositol, glucose, xylitol, sucrose and derivatives thereof, dextrin and derivatives thereof, honey, etc. Sugars, D-panthenol and derivatives thereof, glycolipids, ceramides, achacha extract, almond extract, ashitaba extract, avocado extract, altea extract, arnica extract, hot spring water, aloe extract, usbet Aoi extract, Ogon extract, Aurelia extract, Hypericum extract, Adrianthus extract, Ononis extract, Chamomile extract, Oat extract, Licorice extract, Raspberry extract, Ginkgo biloba extract, Quince seed extract, Kujin Extract, Gardenia extract, Kumazasa extract, Grapefruit extract, Watercress extract, Gentiana extract, Gentian extract, Burdock extract, Sesame extract, Wheat extract, Comfrey extract, Saisin extract, Cactus extract , Savanna extract, salvia extract, hawthorn extract, sage extract, perilla extract, shimotake extract, peony extract, ginger extract, ginger extract, birch extract, mint extract, mallow extract , Senkyu extract, Sakuhakuhi extract, Tachiji Korso extract, camellia extract, toki extract, eucommia extract, corn extract, dokudami extract, tormentilla extract, parsley extract, peppermint extract, barley extract, hamamelis extract, rose extract, cypress extract Product, sunflower extract, pyrrolidone carboxylic acid and its salt, dandelion extract, butcher's bloom extract, grape extract, pruned extract, loofah extract, bodaiju extract, button extract, hop extract, pine extract, Quince extract, Marronnier extract, Mukuroji extract, Mucin, Murasaki extract, Melissa extract, Cornflower extract, Yukinoshita extract, Lily extract, Lime extract, Lavender extract, Apple extract, Gentian extract, Soybean and egg-derived phospholipids, Astragalus extract, oolong tea, green tea And tea extracts such as black tea, urea, Rahan fruit extract, seaweed extract and the like. By blending these humectants, the effect of the present invention can be enhanced.

  The plant extract is not particularly limited in terms of plant extraction site, extraction method, and the like, and is extracted from, for example, whole plant plants, roots, stems, stems, bark, shoots, leaves, flowers, fruits, seeds, or the like. These can be appropriately treated, such as dried, shredded, pressed, or fermented, and extracted using various appropriate solvents at a low temperature or from room temperature to warming. As the extraction solvent, for example, water; a lower monohydric alcohol such as methyl alcohol or ethyl alcohol; or a liquid polyhydric alcohol such as glycerin, propylene glycol, or 1,3-butylene glycol can be used. . Moreover, it can extract using lipophilic solvents, such as hexane, acetone, ethyl acetate, and ether, and what was extracted with oily components, such as squalane, may be used. The obtained extract can be made into a solution, paste, gel, or powder by filtration, ion exchange resin, adsorption, decolorization, and purification. If necessary, purification treatment such as deodorization and decolorization may be further performed within a range not affecting the effect. The effect of this invention can be heightened by mix | blending a plant extract.

  Examples of the antibacterial agent and fungicide include benzoic acid, sodium benzoate, paraoxybenzoic acid ester, parachlorometacresol, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, hinokitiol and the like.

  Examples of the blood circulation promoter include arnica extract, red pepper tincture, ginkgo biloba extract, tocopherol acetate, γ-oryzanol and the like, and examples of the enzyme include lipase and papain.

The sebum production promoter of the present invention can be used as a material for various foods and drinks. Examples of the food and drink (hereinafter simply referred to as “food and drink”) include edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookie, snack, jelly, gummi, tablet confectionery, etc.), noodles (Soba, udon, ramen, etc.), dairy products (milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) And other general foods, health foods (tablets, capsules, etc.), and nutritional supplements (nutrient drinks, etc.). The sebum production promoter of the present invention may be appropriately blended with these foods and drinks.
These foods and drinks can be blended with various ingredients depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. In addition, this anti-inflammatory agent with health maintenance function includes other antioxidants and health food ingredients such as antioxidants (reduced ascorbic acid (vitamin C), vitamin E, reduced glutatin, Tocotrienol, vitamin A derivative, lycopene, lutein, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sesamin, lignans, catechin, isoflavone, chalcone, tannins, flavonoids, coumarin, Isocoumarins, blueberry extract), health food ingredients (V. (vitamin) A, V.B1, V.B2, V.B6, V.B12, VC, VD, VE, VP, choline, niacin, pantothenic acid, folic acid Calcium, EPA, oligosaccharide, dietary fiber, squalene, soybean lecithin, taurine, donariella, protein , Octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium, potassium, heme iron, oyster meat extract, chitosan, chitin oligosaccharide, collagen, chondroitin, turmeric, licorice, shijimi extract, suppon, Licorice, kokushi, keihi, hawthorn, reishi, plantain, chamomile, chamomile, dandelion, hibiscus, honey, boren, royal jelly, lime, lavender, rosehip, rosemary, sage, bifidobacteria, faecalis, lacris, wheat germ oil , Sesame oil, perilla oil, soybean oil, medium chain fatty acid, agaricus, ginkgo biloba extract, turmeric, chondroitin, brown rice germ extract, litchi, onion, DHA, EPA, DPA, green tea, cordyceps, garlic, bee, papaya, pooh , Propolis, Meguri Tree, Yabushitake, Royal Jelly, Saw Palmetto, Hyaluronic Acid, Collagen, Gabba, Harp Seal Oil, Shark Cartilage, Glucosamine, Lecithin, Phosphatidylserine, Seven Carrots, Mulberry Leaf, Soybean Extract, Echinacea, Ekokogi , Barley extract, olive leaf, olive fruit, Gymnema, banaba, Salacia, Garcinia, chitosan, St. John's wort, jujube, carrot, passionflower, broccoli, placenta, pearl barley, grape seeds, peanut seed coat, black cohosh, maria thistle, laurel, Sage, rosemary, ruffa, black vinegar, bitter gourd, maca, safflower, flax, oolong tea, spines, caffeine, capsaicin, xylo-oligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein Prunes, spirulina, barley young leaves, nucleic acids, yeast, shiitake mushrooms, plum meat, amino acids, deep-sea coconut extract, noni, oyster meat, suppon, champignon, plantain, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry, Orange, Fucoidan, Meshima Cobb, Cranberry, Chondroitin Sulfate, Zinc, Iron, Ceramide, Silk Peptide, Glycine, Niacin, Chest Tree, L-Cysteine, Red Wine Leaf, Millet, Horsetail, Biotin, Centella Asiatica, Hascup, Pycnogenol, Japanese cypress, rhubarb, clove, rosemary, catechin, puer, citric acid, brewer's yeast, merirot, black zinger, ginger, gadget, nattokinase, benichouji, tocotrienol, lactoferrin, cinnamon, salmon Buckwheat, cocoa, citron seed extract, real extract perilla, may be blended α- lipoic acid) and the like. In addition, these may mix | blend only 1 type and may use 2 or more types together.

  As a specific production method, the sebum production promoter of the present invention is spray-dried or freeze-dried together with powdered cellulose, and this is easily contained in foods and drinks (instant foods, etc.) by making it into powder, granules, tablets or solutions. Can be made. Moreover, the sebum production promoter of the present invention can be dissolved in, for example, fats and oils, ethanol, glycerin, or a mixture thereof to be liquid and added to beverages or added to solid foods. If necessary, it can be mixed with a binder such as gum arabic or dextrin to form a powder or granules and added to a beverage or a solid food.

  The sebum production promoter of the present invention is added to food and drink for the purpose of maintaining health. The amount added is not limited as long as this purpose is met, but in general, the content of the sebum production promoter in food and drink is preferably 1 to 20%.

  Next, although a reference example, a test example, and an Example are given and this invention is demonstrated further in detail, this invention is not restrict | limited at all by these Examples.

[Example 1]
(Preparation of germinated broccoli extract (purified water extract, 50 vol% ethyl alcohol extract and ethyl alcohol extract))
Broccoli (Brassica oleracea var. Italica) seeds belonging to the Brassica family Brassica were immersed in water at 15 ° C. to 25 ° C. and germinated by indirect sunlight irradiation for 2 to 5 days. Thereafter, whole plants (buds, seeds, roots) having shoots grown to 10 to 30 mm (at this time, the root is about 10 mm) are dried, subjected to a pulverization process, and further using an organic solvent (n-hexane). Degreasing treatment was performed. Thereafter, the degreased product was finely pulverized, sterilized, and sieved to obtain a powder.
10 g of the obtained powdery material was prepared as samples 1 to 3, purified water was used as sample 1, sample 2 was a mixed solvent of water and ethyl alcohol (volume ratio 50:50, hereinafter referred to as “50 vol% ethyl alcohol”), 100 mL each of ethyl alcohol was added to Sample 3 and extracted at room temperature for 7 days, followed by filtration to obtain each extract sample. The sulforaphane content in this 50 vol% ethyl alcohol extract was 4.7%.
The dried solid content of the germinated broccoli purified water extract is 3.3%, the dried solid content of the germinated broccoli 50 vol% ethyl alcohol extract is 3.0%, and the dried solid content of the germinated broccoli ethyl alcohol extract is 2%. 4%.

(Cytotoxicity test of germinated broccoli extract on sebaceous cells)
An appropriate amount of medium was taken in a 24-well plate, seeded with hamster sebaceous cells, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5 vol%. On the next day, the sample preparation solution was added and mixed with the germinated broccoli 50 vol% ethyl alcohol extract obtained above so that the final concentrations were 0 (control), 0.33 mg / ml, and 1 mg / ml, respectively. The medium was changed every 3 days, and the sample preparation solution was added. Two weeks after the start of the culture, the cells were detached with trypsin-EDTA, and the number of cells was counted using a hemocytometer.

(Sebum production promotion test using germinated broccoli extract)
In this Example, a germinated broccoli extract was allowed to act on hamster sebaceous cells, and the amount of sebum produced by hamster sebaceous gland cells was measured using the Oiled O staining method, and the sebum production promoting effect of the germinated broccoli extract was tested. Since Oilred O is nonpolar and fat-soluble, when it comes into contact with tissue, it dissolves in a solvent called lipid in tissue, and as a result, fat staining can be performed. Since it is known that the amount of Oiled O taken into fat and the amount of sebum generated in the cell (triacylglycerol: TG, which is the main component) is correlated, Oilled O is solubilized by this method. It is possible to indirectly measure the sebum production amount of sebaceous cells by measuring the absorbance.

Specifically, the amount of sebum production was measured by the following operation.
An appropriate amount of medium was taken in a 24-well plate, seeded with hamster sebaceous cells, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5 vol%. On the next day, for the germinated broccoli solution obtained in Example 1, the sample preparation solution was added and mixed so that the final concentrations were 0 (control), 0.33 mg / ml, and 1 mg / ml, respectively. The medium was changed every 3 days, and the sample preparation solution was added. Two weeks after the start of the culture, the amount of sebum production was measured by the Oiled O staining method. In addition, the amount of sebum measured by the number of cells determined in the above cytotoxicity test was divided to calculate the amount of sebum produced per cell. The calculated value was normalized with the control sample as 1. The value is shown in FIG.
From the results shown in FIG. 1, unlike the case of treatment with a sample not containing a germinated broccoli extract (0 mg / ml), the sample containing a germinated broccoli extract (0.33 mg / ml, 1 mg / ml) was treated. In this case, it was found that the amount of sebum production per sebaceous cell was promoted.

[Comparative Example 1]
As Comparative Example 1, broccoli grown after germination was subjected to the same degreasing treatment as described above, and the degreased product was finely pulverized, sterilized, and sieved to obtain a powder. The powder as the component derived from this broccoli growth body was subjected to the same extraction treatment as above to obtain an extract of broccoli growth body. The sulforaphane content in this extract was 0.063%. Cytotoxicity tests and sebum production tests were performed as described above. The result is shown in FIG. From the results shown in FIG. 2, it can be understood that the broccoli growth body has almost no sebum production inhibitory action.

[Comparative Example 2]
As Comparative Example 2, a cytotoxicity test and a sebum production test for sulforaphane contained in a large amount in germinated broccoli were carried out in the same manner as described above. A sulforaphane manufactured by Alexis was used. The result is shown in FIG. From the results shown in FIG. 3, it can be understood that sulforaphane has almost no sebum production inhibitory action.

[Example 2: Preparation example of ointment]
An ointment having the following composition was prepared by the following method.
(Ingredient) (%)
(1) Stearic acid 18.0
(2) Cetanol 4.0
(3) dl-α-tocopherol * 1 0.2
(4) Preservative appropriate amount (5) Triethanolamine 2.0
(6) Glycerin 5.0
(7) Purified water remaining amount (8) Germinated broccoli ethyl alcohol extract * 2 1.0
(9) Dipotassium glycyrrhizinate * 3 0.5
(10) Yeast extract * 4 0.5
* 1 Eisai * 2 Manufactured in Example 1 * 3 Maruzen Pharmaceutical * 4 Maruzen Pharmaceutical

(Manufacturing method)
A. A part of components (5), (6) and (7) is heat mixed and kept at 75 ° C.
B. Ingredients (1) to (4) are heated and mixed and maintained at 75 ° C.
C. Gradually add A to B.
D. (8)-(10) which melt | dissolved with the remainder of (7) was added, cooling C, and ointment was obtained.

  All of the ointments prepared in Example 2 were excellent in stability over time, and when applied to the skin, had an effect of continuously supplying oil to the skin and preventing the skin from drying.

[Example 3: Preparation of pack]
A pack having the following composition was prepared by the following method.
(Ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Polyoxypropylene methyl glucoside 5.0
(5) Glycerin 5.0
(6) Purified water remaining amount (7) ethyl alcohol 20.0
(8) Preservative appropriate amount (9) Germinated broccoli purified water extract * 1 0.1
(10) Germinated broccoli ethyl alcohol extract * 1 0.2
(11) Perfume appropriate amount * 1 What was manufactured in Example 1

(Manufacturing method)
A. Components (1) to (6) are mixed, heated to 70 ° C., and stirred.
B. Mix components (7) and (8).
C. The above B was added to the previous A, mixed and then cooled to uniformly disperse (9) to (11) to obtain a pack.

The pack prepared in Example 3 was excellent in stability over time, and using it had the effect of supplying oil to the skin and preventing the skin from drying.
It was a pack to prevent sunburn spots, buckwheat, and aging wrinkles and tarmi.

[Example 4: Preparation of sunscreen emulsion]
A sunscreen emulsion having the following composition was prepared by the following method.
(Ingredient) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Preservative appropriate amount (7) perfume appropriate amount (8) fine particle titanium oxide 10.0
(9) Fine zinc oxide 10.0
(10) Zirconium oxide 5.0
(11) Polystyrene powder 3.0
(12) Trimethylsiloxysilicic acid 0.5
(13) Dipropylene glycol 3.0
(14) Ethyl alcohol 10.0
(15) Purified water remaining amount (16) Salt 0.2
(17) Germinated broccoli ethyl alcohol extract * 1 2.0
(18) Seaweed extract * 2 3.0
* 1 What was manufactured in Example 1 * 2 Made by Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Components (1) to (12) are mixed and dispersed.
B. Components (13) to (16) are mixed and dispersed.
C. Add B to A and emulsify uniformly.
D. Components (17) and (18) were added to C to obtain a sunscreen emulsion.

  The sunscreen emulsion prepared in Example 4 was excellent in stability over time, and when applied to the skin, it had an effect of preventing sunburn, as well as providing oil to the skin and preventing drying of the skin due to sunburn.

Hereinafter, the example of a mixing | blending in the case of mix | blending the skin production promoter of this invention with a foodstuff is shown. The present invention is not limited to the following formulation examples.
Formulation Example 1: Chewing gum
Sugar 51.0%
Gum base 20.0%
Glucose 10.0%
Minamata 16.0%
Fragrance 0.5%
Germinated broccoli ethyl alcohol extract * 1 2.0%
100.0%
* 1 What was manufactured in Example 1

Formulation Example 2: Gummy
Reduced chickenpox 39.0%
Granulated sugar 20.0%
Glucose 20.0%
Gelatin 4.7%
Water 9.68%
Kiwi juice 4.0%
Kiwi flavor 0.6%
Dye 0.02%
Germinated broccoli ethyl alcohol extract * 1 2.0%
100.0%
* 1 What was manufactured in Example 1

Formulation Example 3: Candy
Sugar 48.0%
Minamata 33.0%
Water 14.4%
Organic acid 2.0%
Fragrance 0.2%
Germinated broccoli ethyl alcohol extract * 1 2.0%
100.0%
* 1 What was manufactured in Example 1

Formulation Example 4: Yogurt (hard / soft)
Milk 41.5%
Nonfat dry milk 5.8%
Sugar 8.0%
Agar 0.15%
Gelatin 0.1%
Lactic acid bacteria 0.005%
Germinated broccoli ethyl alcohol extract * 1 2.0%
Perfume
Water residue
100.0%
* 1 What was manufactured in Example 1

Formulation Example 5: Soft capsule
Rice germ oil 86.0%
Emulsifier 12.0%
Germinated broccoli ethyl alcohol extract * 1 2.0%
100.0%
* 1 What was manufactured in Example 1

Formulation Example 6: Soft drink
Fructose glucose liquid sugar 30.0%
Emulsifier 0.5%
Germinated broccoli ethyl alcohol extract * 1 2.0%
Perfume
Purified water residue
100.0%
* 1 What was manufactured in Example 1

Formulation Example 7: Tablet
Lactose 54.0%
Crystalline cellulose 30.0%
Starch degradation product 10.0%
Glycerin fatty acid ester 5.0%
Germinated broccoli ethyl alcohol extract * 1 1.0%
100.0%
* 1 What was manufactured in Example 1

Formulation Example 8: Tablet
74.4% sugar
Glucose 19.0%
Sucrose fatty acid ester 0.2%
Germinated broccoli ethyl alcohol extract * 1 2.0%
Purified water 3.9%
100.0%
* 1 What was manufactured in Example 1

  According to the present invention, a skin production promoter useful for the prevention and treatment of various diseases that are thought to be caused by a decrease in sebum production, such as xerosis, atopic dermatitis, dry skin, cracks, redheads, etc. Can be provided. The skin production promoter of the present invention can be used for a wide range of uses such as pharmaceuticals, quasi drugs, cosmetics, and foods and drinks.

It is a graph which shows the evaluation result of the sebum production promotion effect of Example 1 (germinated broccoli extract). It is a graph which shows the evaluation result of the sebum production promotion effect of the comparative example 1 (broccoli extract grown after germination). It is a graph which shows the evaluation result of the sebum production promotion effect of the comparative example 2 (sulforaphane).

Claims (6)

A sebum production promoter characterized by comprising a germinated broccoli-derived component as an active ingredient. The sebum production promoter according to claim 1, wherein the germinated broccoli-derived component is subjected to a degreasing step. The sebum production promoter according to claim 1 or 2, wherein the germinated broccoli-derived component is a component derived from germinated broccoli containing 32 mg to 160 mg / 100 g of sulforaphane. A topical skin preparation for promoting sebum production, comprising a germinated broccoli-derived component as an active ingredient. The sebum production promotion according to claim 4, further comprising one or more medicinal agents selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, and an ultraviolet light inhibitor. Skin external preparation.   A food and beverage for promoting sebum production, comprising a germinated broccoli-derived component as an active ingredient.

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