JP2008222651A - External preparation for skin in emulsifier form - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external preparation for skin, excellent in a moisture retainability-imparting force in an extent for improving wrinkles. <P>SOLUTION: This external preparation for the skin is characterized by containing (1) amodimethicone and (2) a polyethylene glycerol in a mass ratio of amodimethicone to polyethylene glycerol of 10:1 to 1:1. The emulsifier form is preferably an oil-in-water type emulsifier form. It is further preferable that the external preparation for the skin contains an alkyl-modified carboxyvinyl polymer and/or its salt, and ubidecarenone and/or α-lipoic acid. The ubidecarenone is preferably contained in the form of vesicle. It is preferable that the vesicle contains a hydrogenated phospholipid and phytosterol in addition to the ubidecarenone. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin having an excellent moisturizing effect and thus an effect of improving wrinkles.

  It is said that the decrease in the moisture retention ability in the skin impairs the barrier function of the skin, and at the same time changes the form of the skin and causes wrinkles and the like. For this reason, it has been desired to develop a technique for treating skin with reduced moisturizing ability using an external preparation for skin such as cosmetics and suppressing changes in skin morphology such as wrinkles. As a method for imparting moisture retention to the skin, treatment of the skin with an external preparation for skin containing a polyhydric alcohol having a glycerin skeleton, such as polyglycerin such as glycerin and amodimethicone, is known (for example, (See Patent Document 1, Patent Document 2, and Patent Document 3), but by adding such ingredients, the moisturizing property is imparted to the skin external preparation, but until the skin shape change such as wrinkles is suppressed. It has not reached.

  In addition, the possibility of a technique for containing amodimethicone and polyethylene glycol in combination with an external preparation for skin has been suggested (see, for example, Patent Document 4 and Patent Document 5), but these are combined and contained in an external preparation for skin. It is not done at all.

Japanese Patent Application Laid-Open No. 2006-238221 JP 2006-8893 A JP-T-2006-508171 JP 2005-206573 A JP 2002-47123 A

  This invention is made | formed under such a condition, and makes it a subject to provide the skin external preparation which is excellent in the moisturizing provision | providing force which improves a wrinkle.

In view of such a situation, the present inventors have sought for an external preparation for skin having excellent moisturizing property enough to improve wrinkles. As a result of intensive research efforts, 1) amodimethicone and 2) polyethylene 3) Emulsifier type skin external preparation containing glycol, and 4) such a skin external preparation having a mass ratio of amodimethicone to polyethylene glycol of 10: 1 to 1: 1 shows such action. The present invention has been completed. That is, the present invention is as follows.
(1) Contains 1) amodimethicone and 2) polyethylene glycol, 3) an emulsifier type skin external preparation, and 4) the mass ratio of amodimethicone to polyethylene glycol is 10: 1 to 1: 1. A topical skin preparation characterized by being.
(2) The skin external preparation according to (1), wherein the emulsifier form in the skin external preparation is an oil-in-water emulsifier form.
(3) The external preparation for skin according to (1) or (2), further comprising an alkyl-modified carboxyvinyl polymer and / or a salt thereof.
(4) The external preparation for skin according to any one of (1) to (3), further comprising ubidecarenone and / or α-lipoic acid.
(5) The external preparation for skin according to (4), wherein the ubidecalenone is contained in the form of a vesicle.
(6) The external preparation for skin according to (4) or (6), wherein the vesicle contains hydrogenated phospholipid and phytosterol in addition to ubidecarenone.
(7) 1) Amodimethicone and 2) Polyethylene glycol, and the mass ratio of Amodimethicone to polyethylene glycol is 10: 1 to 1: 1. In addition, 3) Alkyl-modified carboxyvinyl polymer And / or a salt thereof, and further comprising 4) ubidecarenone and / or α-lipoic acid, 5) hydrogenated phospholipid, and 6) phytosterol, 6) The external preparation for skin according to any one of the above.

  ADVANTAGE OF THE INVENTION According to this invention, the external preparation for skin which is excellent in the moisturizing provision power which can improve a wrinkle can be provided.

(1) Amodimethicone which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing amodimethicone as an essential component. Amodimethicone works with polyethylene glycol, which will be described later, and has the effect of imparting excellent moisture retention to the skin. For this reason, the moisturizing property in the skin is enhanced, and the effect of improving wrinkles such as fine lines is exhibited. In order to exhibit such an action, the content of amodimethicone is preferably 1 to 10% by mass, and more preferably 2 to 8% by mass. This is because if the amount is too small, the above-described effect may not be achieved, and if the amount is too large, the effect may reach a limit, and sticky properties or heavy spread may be exhibited.

(2) Moisturizing component that is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains polyethylene glycol as an essential component. Such a sugar component works together with the amodimethicone and has an excellent effect of imparting moisture retention to the skin. Such moisturizing properties cannot be obtained with other polyhydric alcohols such as glycerin and 1,3-butanediol, and cannot be obtained with only amodimethicone. It is expressed only by this combination.

  The preferable content of this component is 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass with respect to the total amount of the external preparation for skin. The above characteristics are manifested within this amount range. In addition, in the relationship with amodimethicone, which is the essential component, the content ratio of amodimethicone: polyethylene glycol is preferably 10: 1 to 2: 1, and 7: 1 to 3: 1. More preferred. This is because if either amodimethicone or polyethylene glycol is too much, the application to moisturizing skin may be impaired.

(3) The external preparation for skin of the present invention The external preparation for skin of the present invention contains the above essential components and is in the form of an emulsifier. The form of the emulsifier form may be either the water-in-oil emulsifier form or the oil-in-water emulsifier form, but the oil-in-water emulsifier form is particularly preferred. Here, the water-in-oil emulsifier form is a term collectively referred to as an emulsifier form having an oil phase in the outer phase, and may contain an aqueous phase in the inner phase or may have an emulsion such as an oil-in-water emulsion. You may do it. Similarly, the oil-in-water emulsifier form is a general term for an emulsion having an aqueous phase in the outer phase, and may have an oil phase in the inner phase or an emulsion such as a water-in-oil emulsion. good. As an emulsifier used for such emulsification, it is preferable to use an ether-based nonionic surfactant such as polyoxyethylene alkyl ether or polyoxybutylene polyglycerin alkyl ether. This is because by using such a surfactant, the total amount of the surfactant can be reduced, and the influence of the surfactant on the skin barrier function can be reduced. The total amount of the surfactant is preferably 1 to 4% by mass, more preferably 1.5 to 3% by mass with respect to the total amount of the external preparation for skin. In addition to the surfactants described above, non-surfactants that are usually used in skin preparations such as cosmetics can be contained. Furthermore, it is also preferable to contain an alkyl-modified carboxyvinyl polymer and / or a salt thereof in the sense of keeping the emulsified state stable. The preferable content of such components is 0.01 to 0.5 mass%, more preferably 0.05 to 0.3 mass%, based on the total amount of the external preparation for skin. Such a component is preferably contained also in that sense because it forms a composite film with the essential ingredient amodimethicone after administration to the skin and enhances the effect of amodimethicone. Such alkyl-modified carboxyvinyl polymers include commercially available products, which can be purchased and used. Examples of preferable commercial products include “Carbopol 1382”, “Pemlen TR-1”, “Pemlen TR-2” and the like sold by Goodrich.

  In order to further improve the function of the external preparation for skin of the present invention, which imparts moisture retention and improves wrinkles, it is also preferable for the external preparation for skin of the present invention to contain components that are effective in improving wrinkles. As such components, for example, α-lipoic acid and / or a salt thereof, ubidecalenone, raspberry (Rosaceae raspberry) fruit juice extract, soybean isoflavone and the like can be preferably exemplified. Components having a problem in stability such as α-lipoic acid and ubidecalenone are preferably processed and contained in vesicles with components such as phospholipid, phytosterol and ceramide. As the phospholipid used at this time, it is preferable to use a hydrogenated phospholipid such as hydrogenated lecithin because the stability is further improved. A particularly preferred vesicle is a vesicle having a composition of 0.5 to 2 parts by mass of phytosterol and 7 to 15 parts by mass of hydrogenated phospholipid with respect to 0.5 to 2 parts by mass of α-lipoic acid or ubidecarenone. The vesicle is preferably contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. In addition, it is preferable that the extract of raspberry juice is processed into a product containing 100 nM or more of raspberry ketone or its glycoside. The preferred content is preferably 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. Soy isoflavone is preferably in the form of a glycoside and contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin.

  The external preparation for skin of the present invention can contain, in addition to such components, optional components that are usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oils such as beeswax, owl, hardened castor oil, beeswax, candelilla wax, carnauba wax, botarou, lanolin, reduced lanolin, hard lanolin, jojoba wax , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Chain polysiloxanes such as Loxane and diphenylpolysiloxane; Cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc. Oils such as silicone oils such as modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkyl sulfate triethanolamine ether; stearyltrimethylammonium chloride, chloride Cationic surfactants such as benzalkonium and laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide) 1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan monostearate, sesquioxide) Sorbitan oleate, etc.), glycerin fatty acids (eg glyceryl monostearate), propylene glycol fatty acid esters (eg propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monoole) Acid, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin) Monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether, etc.), Pluronic type , POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl Nonionic surfactants such as glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, xylitol, propylene glycol, dipropylene glycol, amodimethicone, a Polyhydric alcohols such as prene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; moisturizing composition such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate Classification: The surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic acid (silica), aluminum oxide, barium sulfate, etc .; surface treated Bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments; surface may be treated, mica titanium, fish phosphorus foil, bismuth oxychloride Pearl agents such as red 202, red 228, red 226, yellow 4, blue 404, yellow, which may be raked Organics such as Color No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc. Colors: Organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; paraaminobenzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; UV absorbers; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, etc. UV absorbers; lower alcohols such as ethanol and isopropanol; vitamin A or its derivatives, vitamin B6 Vitamin Bs such as acid salts, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B12, vitamin B15 or derivatives thereof; α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, etc. Preferred examples include vitamins such as vitamin E, vitamin D, vitamin H, pantothenic acid, panthetin, and pyrroloquinoline quinone; and antibacterial agents such as phenoxyethanol. The skin external preparation of this invention can be manufactured by processing the said essential component, a preferable component, and an arbitrary component in accordance with a conventional method. The external preparation for skin thus obtained is excellent in moisture retention and thus has an effect of improving wrinkles.

  The skin external preparation of the present invention can be applied without particular limitation as long as it is externally applied to the skin, and examples thereof include cosmetics, skin external medicines, skin external goods, and the like. It is particularly preferable to apply it to a cosmetic because of its function. The cosmetic is not particularly limited, but is particularly preferably applied to skin care cosmetics, ultraviolet protective cosmetics, and the like.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  According to the formulation shown below, an oil-in-water emulsifier type cosmetic that is an external preparation for skin of the present invention was produced. That is, the ingredients of (i), (ii) and (c) are heated to 80 ° C., (ii) is added to (ii) and neutralized, and then gradually added to the mixture under emulsification, emulsified, stirred and cooled, and an emulsion 1 in the form of an oil-in-water emulsifier. (Cosmetics) was obtained. In the same manner, Comparative Example 1 in which amodimethicone was substituted with glycerin and Comparative Example 2 in which polyethylene glycol was substituted with glycerin were also produced in the same manner.

<Manufacturing method of ubidecarenone-containing vesicle>
80% by mass of hydrogenated lecithin and 10% by mass of phytosterol are melted at 90 ° C., cooled to 60 ° C., uniformly dispersed by adding 10% by mass of ubidecarenone, rapidly cooled to 0 ° C., and vesicle mass This was pulverized with a jet mill to obtain vesicles having an average of 20 μm.

<Test Example 1>
For the emulsion 1, Comparative Example 1 and Comparative Example 2, the transdermal water transpiration (TEWL) was measured using Tewameter (Courage + Khazaka) using the tape-stripped region of the upper arm inner part. That is, after tape stripping, the sample was allowed to stand for 10 minutes, and then TEWL was measured. The sample was administered at a dose of 5 mg per 1000 mm 2 and allowed to stand for 10 minutes, and then TEWL was measured again. TEWL after treatment was divided by TEWL before treatment and multiplied by 100 to obtain TEWL suppression rate. The results are shown in Table 2. From this, it can be seen that the emulsion 1 which is an external preparation for skin of the present invention is excellent in the action of suppressing TEWL.

<Test Example 2>
The sample is administered to healthy skin at a dose of 5 mg per 1000 mm2 and left to stand for 10 minutes. A replica of this part is collected, and this is irradiated obliquely at 45 ° C. The percentage of the total area was measured and used as an index of skin irregularities. Untreated sites were also measured as subjects. The shadow produced by light irradiation from this angle is due to deep irregularities, and is usually an indicator of fine lines. The results are shown in Table 3. From this, it can be seen that the external preparation for skin of the present invention has an excellent unevenness correction effect such as fine lines.

  By operating in the same manner as emulsion 1, emulsion 2 (cosmetics), which is an external preparation for skin of the present invention having the following formulation, was prepared. However, the TEWL suppression rate according to Test Example 1 was 33%, and the shadow percentage of the Test Example was 18%. It can be seen that alkyl-modified carboxyvinyl polymers and / or salts are preferred over carboxyvinyl polymers.

  By operating in the same manner as emulsion 1, emulsion 3 (cosmetics), which is a skin external preparation of the present invention, having the following formulation, was prepared. However, the TEWL suppression rate according to Test Example 1 was 42%, and the shadow percentage of the Test Example was 13%.

<Method for producing α-lipoic acid-containing vesicle>
80% by mass of hydrogenated lecithin and 10% by mass of phytosterol were melted at 90 ° C., cooled to 60 ° C., uniformly dispersed by adding 10% by mass of α-lipoic acid, and rapidly cooled to 0 ° C. A vesicle mass was prepared and pulverized with a jet mill to obtain vesicles having an average of 18 μm.

  The present invention can be applied to external preparations for skin such as cosmetics.

Claims (7)

1) containing amodimethicone and 2) polyethylene glycol, 3) an emulsifier-type skin external preparation, and 4) the mass ratio of amodimethicone and polyethylene glycol is 10: 1 to 1: 1. A topical skin preparation. The skin external preparation according to claim 1, wherein the emulsifier form in the skin external preparation is an oil-in-water emulsifier form. The skin external preparation according to claim 1 or 2, further comprising an alkyl-modified carboxyvinyl polymer and / or a salt thereof. The external preparation for skin according to any one of claims 1 to 3, further comprising ubidecarenone and / or α-lipoic acid. The external preparation for skin according to claim 4, wherein the ubidecalenone is contained in the form of a vesicle. The external preparation for skin according to claim 4 or 6, wherein the vesicle contains hydrogenated phospholipid and phytosterol in addition to ubidecarenone. 1) containing amodimethicone and 2) polyethylene glycol, and the mass ratio of said amodimethicone to polyethylene glycol is 10: 1 to 1: 1, in addition, 3) alkyl-modified carboxyvinyl polymer and / or The salt thereof, and further containing 4) ubidecalenone and / or α-lipoic acid, 5) hydrogenated phospholipid, and 6) phytosterol. The external preparation for skin according to Item.