JP2008246081A - Priming method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a priming method permitting automatic priming without attaching/detaching a pack filled with a priming solution. <P>SOLUTION: The priming method is executed by a hemocatharsis control device for a hemocatharsis circuit comprising a filter for purifying the blood and an autotransfusion line connected to a blood outlet of the filter. The priming method comprises a first step of closing the autotransfusion line (closing an autotransfusion valve in the step S6) and a second step of feeding the priming solution to the autotransfusion line disposed between the position where the autotransfusion line is closed and the filter (operation of an auxiliary liquid pump in the step S4). <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a priming method for automatically priming a blood purification circuit by a blood purification control device that controls a flow of liquid in a blood purification circuit having a filter for purifying blood.

  For patients whose kidney function is reduced due to illness or the like, blood purification such as hemodialysis is performed by medical personnel. The blood purification control apparatus controls the flow of the liquid flowing through the blood purification circuit so as to clean the patient's blood safely and efficiently. The blood purification circuit includes a blood circuit through which the patient's blood flows and a liquid supply circuit through which dialysate and replacement fluid flow, and is attached to the blood purification control device.

  Priming is performed as a preparation before the patient's blood is purified. Priming is to fill the circuit with a priming solution such as physiological saline for the purpose of cleaning the blood purification circuit and removing air.

  Here, the circuit is a flow path through which blood, dialysate, replacement fluid, and the like flow, and is formed by a filter, a chamber, a needle, a tube, and the like. A filter is an instrument that purifies blood by material exchange between blood and dialysate according to principles such as diffusion and ultrafiltration. The chamber is an instrument that traps bubbles in the liquid passing through the line. A needle is an instrument that is attached to a circuit at the time of surgery, and is punctured at each of a removal location such as a patient shunt and a blood return location in order to take blood from the body and return the blood to the body. The tube is attached to a connection port provided in these instruments, and connects the instruments.

  The chamber has an original function of trapping bubbles in the blood when it flows in the direction in which blood should flow (hereinafter referred to as “forward direction”) during the treatment. Therefore, in order to fill the interior with the priming liquid, the priming liquid is allowed to flow in the forward direction with the top of the chamber reversed from that during blood purification, or the priming liquid is left in the state where the chamber top is in the state of blood purification. Must flow in the opposite direction.

  Moreover, it is difficult for the filter to flow the priming liquid in the forward direction and fill the inside with the priming liquid because of its structure. Therefore, in order to fill the inside of the filter with the priming liquid, like the chamber, the priming liquid is allowed to flow in the forward direction with the top of the filter reversed from the time of blood purification, or the top of the filter is It is necessary to flow the priming solution in the reverse direction while maintaining the blood purification state.

  Conventionally, at the time of priming, the pack containing the priming solution is connected to the blood return port, and the pump is operated so that a pressure difference is generated in the opposite direction to that during the operation. A blood purification control device that circulates in a direction and a priming method thereof have been proposed (see, for example, Patent Document 1).

In addition, since the priming operation is performed to remove bubbles and foreign substances from the circuit and the filter (blood purifier), it is necessary to wash with a sufficient amount of the priming liquid. In addition, it is also required to reduce the amount of the cleaning liquid within a possible range because the replacement operation of the storage container is excluded. Therefore, a so-called rinse-type cleaning operation is widely performed in which the cleaning liquid that has passed through the circuit or the filter only once is not discarded as it is, but is drained after being recirculated. (For example, refer to Patent Document 2).
JP 2006-175103 A No. 5-19076

  However, the conventional priming method has a problem that it is necessary to connect the pack storing the priming solution at the time of priming to the blood return port and to remove it when the priming is completed.

  Conventionally, the priming solution is poured from the blood return port of the blood circuit and discharged from the blood removal port. Therefore, at the time of priming, the operator connects the pack storing the priming solution to the blood return port. When the priming is completed, the operator removes the pack storing the priming solution in order to attach the blood return device to the blood return port. Thus, it is troublesome for the operator to connect the pack storing the priming solution and remove it later. In addition, it is desirable from the viewpoint of hygiene that the number of procedures for connecting and disconnecting circuits is as small as possible.

  Further, as described above, it is desirable that the amount of liquid for completing the priming operation is small in order to save the trouble of replacing the pack and also from the viewpoint of cost reduction.

  In addition, what is important in the conventional recirculation-type cleaning operation is the amount of fluid supplied by the replacement pump that feeds into the blood circuit and the amount of fluid sent by the blood pump that feeds in the blood circuit. If the amount of blood pump that sends liquid such as blood or priming fluid in the blood circuit is greater than the amount of fluid supplied from the replacement pump that sends priming fluid from outside the circuit into the blood circuit, the filter Excessive negative pressure may be applied to the priming fluid flowing through the. Therefore, conventionally, there is a problem that air is taken into the filter from the outside and the air remains in the filter after priming.

  If air remains in the circuit after priming, there is a risk that the blood in the circuit will clot and the blood cannot be purified. In addition, if the remaining air enters the patient's body through the circuit, it will affect the patient's life.

  Conversely, if the flow rate of the replacement fluid pump is higher than the flow rate of the blood pump, excessive pressure is applied to the filter, which may damage the filter. As a result, the patient's blood cannot be purified safely and sufficiently.

  There is a certain error in the pressure applied by the pump. In the pump generally used for the blood purification control apparatus, it is actually difficult to control the positive pressure and the negative pressure applied to the filter so as to keep a constant balance due to this error. That is, the conventional technique has a problem that priming that can realize a safe treatment cannot be performed.

  The present invention has been made to solve the above-described problems, and an object of the present invention is to provide a priming method capable of automatically performing priming without attaching / detaching a pack storing priming liquid during treatment. .

  “At the time of treatment” refers to the period from the start to the end of blood purification of a patient.

  A “filter” is also called a dialyzer and is an instrument that purifies blood. A typical filter passes a bunch of hollow fibers through a cylinder, allows blood to pass through the hollow fibers, and indirectly contacts the dialysate flowing in the cylinder via a hollow fiber membrane. By purifying the blood. Due to the principle of diffusion, ultrafiltration and osmotic pressure, waste products in the blood such as urea, uric acid and creatine are discharged into the dialysate, and electrolytes in the dialysate are taken into the blood.

  The “chamber” is a gas-liquid separator that removes bubbles and foreign substances contained in the liquid flowing into the interior and flows out the liquid from which the bubbles have been removed. The chamber of the blood purification circuit generally traps air bubbles in the liquid flowing inside the chamber by collecting the air bubbles in the liquid on the inlet side of the chamber by utilizing the property that the air bubbles rise in the liquid. Some “chambers” have a function of separating foreign substances by incorporating a mesh.

  “Supply solution” is a general term for “priming solution”, “replacement solution”, and “dialysis solution”. In general, physiological saline or the like is used for “liquid supply”.

  “Priming liquid” refers to a liquid used for priming of the blood purification control apparatus. “Replacement fluid” refers to a liquid that is mixed during blood return in order to replenish the water of blood lost by passing through a filter. The “dialysate” refers to a liquid that exchanges substances with blood in a filter.

  The “filtrate” refers to dialysate after purifying blood.

  A “pump” is a device that applies pressure to cause the liquid in the circuit to flow.

  The “valve” is a device that adjusts the flow rate of the liquid in the circuit and closes the flow path at the mounting position. “Close the valve” means to close the flow path of the liquid in the circuit at the mounting position, and “open the valve” means to flow the liquid in the circuit at the mounting position. For example, when the circuit is a tube having a certain elasticity, it is possible to close the flow path by attaching an instrument for pinching the tube from the outside, and pinching the normally opened tube from the outside.

  A “circuit” is a flow path through which liquid flows. Specifically, the circuit is a flow path through which blood, priming solution, replacement fluid, and dialysate flow, and is realized by a combination of a filter, a chamber, a branch pipe, a tube, and the like. The circuit is divided into a “blood circuit” and a “fluid supply circuit” depending on the liquid flowing inside during the treatment, and blood flows through the blood circuit, and replacement fluid and dialysate flow through the liquid supply circuit. “Line” means a part of a circuit.

  “Forward direction” refers to the direction in which liquid flows in the circuit during treatment. The “reverse direction” refers to the direction opposite to the forward direction. The “forward direction” of circuits that are not attached at the time of treatment and lines that do not allow liquid to flow are defined individually.

  In order to achieve the above object, there is provided a priming method executed by a blood purification control apparatus for a blood purification circuit having a filter for purifying blood and a blood return line connected to a blood discharge port of the filter. A first step of closing a blood return valve provided in the blood return line, and a second step of feeding a priming solution into the blood return line between the blood return valve and the filter.

  Thus, the method includes the steps of closing the blood return valve and feeding priming liquid to the blood return line between the closed position and the filter. Thereby, a priming liquid is sent into the inside of a filter from the blood discharge port of a filter. In other words, the priming liquid can be flowed through the filter in the direction opposite to the blood flow during the treatment without attaching or removing the pack storing the priming liquid. Therefore, it is possible to automatically execute priming without attaching / detaching the pack storing the priming liquid.

  Preferably, the blood purification circuit further includes a blood removal line connected to a blood inlet of the filter, and further a third flow for allowing the priming liquid sent to the filter to flow into the blood removal line. Includes steps.

  In this way, the priming solution is sucked out of the filter. Thereby, the pressure (positive pressure) which sends in a priming liquid and the pressure (negative pressure) which draws out can be applied to a filter. Thus, by applying a positive pressure and a negative pressure to the filter, it is possible to make the flow of the priming liquid in the filter smooth.

  More preferably, in the second step, the priming liquid is fed at a flow rate greater than the flow rate at which the priming liquid flows out in the third step.

  When the negative pressure applied to the filter is applied, air comes out of the hollow fiber, so that the air in the blood circuit, which is the purpose of priming, cannot be removed. A positive pressure can be applied to the filter by controlling the magnitude of the positive pressure to be greater than the magnitude of the negative pressure. Therefore, it is possible to ensure air removal by priming.

  More preferably, it further includes a fourth step of opening the blood return line, and the first step is executed after the second step and the fourth step.

  In this way, after the blood return line is opened and the priming liquid is fed into the blood return line, the filter is primed. Thereby, when the blood return valve is opened, it is possible to prevent the priming liquid filled in the filter or the like from coming out through the blood return line. Therefore, it is possible to prime the blood return line and the filter with simple control without complicating the blood purification control device and the control by the blood purification control device such as newly providing a valve.

  More preferably, the blood purification circuit further includes a chamber in the middle, and connects the blood return line and the blood removal line, so that the filter, the blood removal line, and the blood return line are annular. And after the priming of the blood purification circuit is completed, the fifth step of circulating the priming liquid to the circuit that is annular by opening the blood return valve and circulating the priming liquid. Including.

  Thus, after the priming of the blood purification circuit having the auxiliary circuit having the chamber is completed, the recirculation is performed. Thereby, the air in the blood purification circuit that has not been completely removed by priming can be trapped in the chamber of the auxiliary circuit. Since the auxiliary circuit is unnecessary for the treatment, it can be removed and discarded at the time of the treatment. Therefore, the air remaining after priming can be removed with a simple operation.

  More preferably, it further includes a sixth step of feeding a priming solution from the dialysate blood removal port of the filter.

  In this way, the priming solution flows from the dialysate inlet to the filter. Thereby, the line which flows a dialysate into a filter, and the liquid supply circuit part of a filter can be primed.

  More preferably, it further includes a seventh step of allowing the priming liquid to flow out from the dialysate discharge port of the filter after the dialysis circuit portion of the filter is filled in the sixth step.

  Thus, after the priming liquid is filled in the liquid supply circuit portion of the filter, the priming liquid is sucked out from the dialysate discharge port of the filter. Thereby, the liquid supply circuit part of a filter can be primed.

  In this way, all the priming of the liquid supply circuit can be performed by a series of procedures in which the priming liquid is fed from the dialysate line to the filter and the priming liquid is sucked from the filter to the filtrate line.

  More preferably, the blood purification circuit further includes a container into which the priming liquid flowing out from the dialysate discharge port of the filter is fed, and a dialysate discharge line connecting the dialysate discharge port of the filter and the container. And a disposal line for discarding the priming liquid stored in the container, and further, after the eighth step, the eighth step of sending the priming liquid flowing out from the dialysate discharge port of the filter to the container, and And a ninth step of discarding a part of the priming liquid fed into the container via the disposal line and adjusting the remaining amount of the priming liquid in the container.

  In this way, by controlling the discard valve, the priming solution is accumulated in the container for storing the priming solution discharged from the dialysate discharge port, and a part of the accumulated priming solution is discarded. Thereby, when the progress of dialysis is monitored and controlled by the amount of the dialyzed solution (filtrate) after filtration stored in the container at the time of treatment, the amount of priming solution stored in the container can be adjusted in advance. . Therefore, a certain amount of the priming liquid is accumulated in advance, and the progress of the treatment can be detected more accurately than in the case where the treatment is started from a state in which there is no priming liquid in the container.

  According to the priming method of the present invention, it is possible to perform priming that ensures cleaning in the circuit and removal of air without taking the trouble of removing the container in which the priming liquid is stored at the time of treatment or changing the mounting position. Automatic execution is possible. Therefore, reliable priming can be performed by a simple priming operation.

  A blood purification circuit is attached to a blood purification control device that executes the priming method according to the present invention. The blood purification control device controls a pump and a valve according to a predetermined rule based on information obtained from a sensor or the like. The patient's blood and fluid flow through the blood purification circuit according to the control of the blood purification control device. Thereby, the blood is purified.

  First, the configuration of the blood purification control apparatus will be described with reference to the drawings.

  FIG. 1 is a block diagram showing a configuration of a blood purification control apparatus according to an embodiment of the present invention.

  The blood purification control apparatus 10 according to the present embodiment is an apparatus that performs control for automatically executing priming. The blood purification control device 10 is also a device that controls blood purification of a patient by a plurality of operation methods (operation modes). In the present embodiment, as an operation mode, an auto priming mode, a CHD (Continuous Hemodialysis) mode, a CHDF (Continuous Hemodiafiltration) mode, a CHF (Continuous Hemofiltration) mode, and an ECUM (Extramantulation Modulation mode) are provided. And

  The blood purification control apparatus 10 includes an input unit 12, a display unit 14, a mode receiving unit 16, a blood pump 20, a dialysis pump 22, a filtrate pump 24, a replacement fluid pump 26, a fluid supply valve 30, Filtrate valve 32, blood return valve 34, priming fluid discharge valve 36, filtrate pressure sensor 40, blood pressure drop sensor 42, inflow pressure sensor 44, discharge pressure sensor 46, and control method storage unit 48 The control part 49 is provided.

  In the input unit 12, an operator of the blood purification control apparatus 10 inputs an operation mode of the blood purification control apparatus.

  The display unit 14 is a part that presents information to the operator, and is, for example, a monitor screen.

  The mode receiving unit 16 receives information indicating the operation mode input to the input unit 12.

  The blood pump 20 is a pump that applies pressure to extract blood from a patient. The blood pump 20 not only has a direction in which the liquid in the circuit flows during the operation (hereinafter, the pressure direction of such a pump is referred to as “forward direction”), but also in the opposite direction (hereinafter, such a pump). The pressure direction can be referred to as “reverse direction”).

  The dialysis pump 22 is a pump that applies pressure to flow the dialysate.

  The filtrate pump 24 is a pump that applies pressure to flow the filtrate.

  The replacement fluid pump 26 is a pump that applies pressure to flow the replacement fluid.

  The liquid supply valve 30 is a valve for adjusting the supply amount of the liquid supply and stopping the supply.

  The filtrate valve 32 is a valve for adjusting the discharge amount of the filtrate and stopping the discharge.

  The blood return valve 34 is a valve that adjusts the amount of blood discharged from the filter to the patient and stops the blood return.

  The priming fluid discharge valve 36 is a valve that adjusts the flow rate of the rapid replacement fluid that is used when it is necessary to rapidly supplement the replacement fluid and stops the rapid replacement fluid.

  The filtrate pressure sensor 40 is a sensor that measures the pressure of the line through which the filtrate flows.

  The blood pressure removal sensor 42 and the inflow pressure sensor 44 are sensors that measure the pressure at which the blood before purification, taken out from the patient by the action of the blood pump 20, flows. The blood pressure removal sensor 42 measures the pressure of blood flowing through the line on the patient side from the blood pump 20, and the inflow pressure sensor 44 measures the pressure of blood flowing through the line on the filter side from the blood pump 20.

  The discharge pressure sensor 46 is a sensor that measures the pressure of blood discharged from the filter 56.

  The control method storage unit 48 stores information related to the operation mode control method provided by the blood purification control device 10. The control method storage unit 48 of the present embodiment is a storage medium that stores automatic priming mode information 48a, CHD mode information 48b, CHDF mode 48c information, CHF mode information 48d, and ECUM mode information 48e. is there.

  The automatic priming mode information 48a is information including a method for controlling a pump and a valve when the blood purification control apparatus 10 automatically performs priming.

  The CHD mode information 48b, the CHDF mode 48c information, the CHF mode information 48d, and the ECUM mode information 48e are information including a method for controlling a pump and a valve in order to purify blood by each blood purification method. The CHD mode information 48b is information including a control method for performing continuous dialysis hemodialysis (CHD), and the CHDF mode 48c information includes a control method for performing continuous dialysis filtration (CHDF). Information, the CHF mode information 48d is information including a control method for performing continuous loose blood filtration (CHF), and the ECUM mode information 48e is a control method for performing ultrafiltration (ECUM). It is information to include.

  The control unit 49 reads information corresponding to the operation mode received by the mode receiving unit 16 from the control method storage unit 48, and refers to information acquired from the pressure sensor and each sensor (not shown) based on the read information, Control the pump and each valve.

  Next, the configuration of a circuit attached to the blood purification control apparatus 10 capable of executing such a plurality of blood purification methods will be described with reference to the drawings.

  FIG. 2 is a diagram showing a configuration of a blood purification circuit during priming according to an embodiment of the present invention and a positional relationship among a pump, a valve, and a pressure sensor of the blood purification control device.

  The blood purification circuit during priming includes a first liquid supply pack 50, a second liquid supply pack 52, a filtrate pack 54, a filter 56, a blood return chamber 58, a recirculation chamber 60, The liquid branch pipe 62, the rapid replacement liquid branch pipe 64, the anticoagulation branch pipe 66, the blood removal side joint 68a, the blood removal side joint 68b, the blood return side joint 70a, the blood return side joint 70b, and the first Supply line 72, second supply line 74, dialysate line 76, filtrate line 78, waste liquid line 80, replacement liquid line 82, first blood removal line 84, and priming liquid discharge (rapid replacement liquid) ) Line 86, second blood removal line 88, third blood removal line 89, anticoagulant (bypass) line 90, first blood return line 92, second blood return line 94, and first circulation. Line 96 and second circulation line 98 are provided. That.

  In this figure, in order to explain the positional relationship of each pump, each valve, and each sensor included in blood purification control device 10 in the blood purification circuit, blood pump 20, dialysis pump 22, filtrate pump 24, and replacement fluid Pump 26, liquid supply valve 30, filtrate valve 32, blood return valve 34, priming liquid discharge valve 36, filtrate pressure sensor 40, blood pressure sensor 42, inflow pressure sensor 44, and discharge pressure A sensor 46 is also shown. Since each part with which these blood purification control apparatuses 10 are provided was demonstrated with reference to FIG. 1, description is abbreviate | omitted here.

  The first liquid supply pack 50 is a container in which liquid supply is first stored.

  The second liquid supply pack 52 is a container in which the liquid supply supplied from the first liquid supply pack 50 is stored.

  The filtrate pack 54 is a container in which a filtrate that is a dialysate after blood purification is stored. The filtrate pack 54 corresponds to a “container” described in the claims.

  In the present embodiment, it is assumed that the liquid used as the priming liquid and the dialysis liquid is the same as the liquid used as the replacement liquid. The liquid supply supplied from the first liquid supply pack 50 is temporarily stored in the second liquid supply pack 52 and then supplied to another blood purification circuit. During the blood purification, the supply liquid stored in advance in the second supply liquid pack 52 is used as a replacement liquid and dialysate, and the supply liquid is not replenished from the first supply liquid pack 50 to the second supply liquid pack 52. . Further, the filtrate after blood purification is stored in the filtrate pack 54.

  Thereby, the exact weight of the 2nd liquid supply pack 52 and the filtrate pack 54 during treatment can be measured, for example. When the control unit 49 acquires these measurement results, it is possible to realize automatic control based on the progress of blood purification and the amount taken into the patient's body as a replacement fluid.

  The filter 56 is an instrument that purifies blood. In the filter 56 shown in this figure, blood flows in from the blood inlet provided in the upper part of the cylinder, and the blood is discharged from the blood outlet provided in the lower part of the cylinder. In addition, the dialysate flows from the dialysate inlet provided at the lower side of the cylinder and the dialysate after purifying the blood from the dialysate outlet provided at the upper side of the cylinder, that is, the filtrate Discharged.

  In this figure, the inside of the dotted line in the filter 56 schematically shows the inside of the hollow fiber which is a blood flow path, and the outside of the dotted line schematically shows the outside of the hollow fiber which is a dialysate flow path. The inside of the dotted line of the filter 56 is a part of the blood circuit, and the direction from the blood inlet to the blood outlet is the forward direction. Further, the outside of the dotted line of the filter 56 is a part of the liquid supply circuit, and the direction from the dialysate inlet to the dialysate outlet is the forward direction.

  The blood return chamber 58 is a part that traps air bubbles in the blood discharged from the filter 56 side and in which a replacement fluid is mixed into the blood return.

  The recirculation chamber 60 traps bubbles remaining in the blood circuit after priming during recirculation. Here, “recirculation” means that the priming fluid is circulated in the blood circuit after the filling of the priming fluid into the blood purification circuit is completed and before the patient is treated.

  These chambers structurally trap bubbles in the liquid flowing in the forward direction but cannot trap in the reverse direction. Thus, the chamber can be primed by flowing fluid in the opposite direction.

  The supply liquid branch pipe 62 is a branch pipe that separates the supply liquid into dialysate and replacement fluid.

  The rapid replacement fluid branch pipe 64 is a branch pipe that rapidly mixes a replacement fluid or the like into blood taken from a patient.

  The anticoagulant branch tube 66 is a branch tube that mixes an anticoagulant into blood taken from a patient.

  The blood removal side joint 68a and the blood removal side joint 68b are detachable joint members. At the time of priming, as shown in this figure, the blood removal side joint 68a and the blood removal side joint 68b are connected.

  During the treatment, the blood removal side joint 68a and the blood removal side joint 68b are removed. In addition, a device for taking out blood from the patient is attached to the blood removal side joint 68a at the time of treatment instead of the blood removal side joint 68b. An example of an instrument attached to the blood removal side joint 68a is a needle that is punctured by a patient. The patient's blood is taken into the blood purification circuit through an instrument such as a needle.

  The blood return side joint 70a and the blood return side joint 70b are detachable joint members. At the time of priming, as shown in the figure, the blood return side joint 70a and the blood return side joint 70b are connected.

  During the treatment, the blood return side joint 70a and the blood return side joint 70b are removed. In addition, a device for returning blood to the patient's body is attached to the blood return side joint 70a at the time of treatment instead of the blood return side joint 70b. An example of an instrument attached to the blood return side joint 70a is a needle that is punctured by a patient. The purified blood is returned to the patient through the needle.

  As described above, the blood-removing side joint 68a and the blood-returning side joint 70a are different from each other in instruments that are attached at the time of treatment and at the time of priming. Therefore, the blood removal side joint 68a has a shape in which both the blood removal side joint 68b and a device for taking out blood from the patient can be attached and detached. The blood return side joint 70b has a shape in which both the blood return side joint 70a and an instrument for returning blood to the patient's body can be attached and detached.

  By providing the blood removal side joint 68a and the blood return side joint 70a having such a shape, the operator of the blood purification control device and the blood purification circuit can easily go from recirculation after priming to treatment. It becomes possible to migrate.

  The first liquid supply line 72 is a line through which the liquid supply flows in the direction from the first liquid supply pack 50 to the second liquid supply pack 52 during the treatment. Further, as shown in the figure, the first liquid supply line 72 is provided with the liquid supply valve 30 in the middle thereof.

  The second liquid supply line 74 is a line through which the liquid supply flows from the second liquid supply pack 52 toward the liquid supply branch pipe 62 during the treatment.

  The dialysate line 76 is a line through which the dialysate flows from the supply liquid branch pipe 62 to the dialysate inlet of the filter 56 during the treatment. Moreover, as shown in this figure, the dialysate line 76 is provided with the dialysis pump 22 in the middle thereof.

  The filtrate line 78 is a line through which the filtrate flows from the dialysate discharge port of the filter 56 toward the filtrate pack 54. Moreover, as shown to this figure, the filtrate pump 24 is attached to the filtrate line 78 in the middle.

  The waste liquid line 80 is a line for discarding the filtrate stored in the filtrate pack 54 by the treatment. Moreover, as shown in this figure, the filtrate valve 32 is attached to the waste liquid line 80 in the middle thereof.

  The filtrate valve 32 is closed at the time of measurement, and the filtrate does not flow into the waste liquid line 80. After weighing, the filtrate valve 32 is opened, and the filtrate flows from the filtrate pack 54 toward the open end. The direction in which this filtrate flows is defined as the “forward direction” of the waste liquid line 80.

  The replacement fluid line 82 is a line through which the replacement fluid flows from the supply fluid branch pipe 62 toward the blood return chamber 58 during the treatment. Further, as shown in the figure, the replacement fluid line 82 is attached with the replacement fluid pump 26 in the middle.

  The first blood removal line 84 is a line through which blood before purification flows from the blood removal side joint 68a in the direction of the anticoagulant branch tube 66 during the treatment.

  The priming fluid discharge (rapid replacement fluid) line 86 is a line through which the replacement fluid flows when it is necessary to rapidly supplement the blood being purified during the treatment. That is, it is a line that connects a quick replacement fluid pack (not shown) and the quick replacement fluid branch pipe 64 at the time of treatment. The replacement fluid flows from a replacement fluid pack (not shown) in the direction of the rapid replacement fluid branch pipe 64. At the time of priming, it becomes a priming solution disposal line, one end is connected to the rapid replacement fluid branch pipe 64 and the other end is opened.

  As shown in the figure, the priming liquid discharge valve 36 is attached to the priming liquid discharge (rapid replacement liquid) line 86 in the middle.

  The second blood removal line 88 is a line that allows blood before purification to flow from the rapid replacement fluid branch pipe 64 to the anticoagulation branch pipe 66 during the treatment. As shown in the figure, the blood removal pump 88 is attached to the second blood removal line 88 on the way.

  The third blood removal line 89 is a line for flowing blood before purification from the anticoagulant branch tube 66 toward the blood inlet of the filter 56 during the treatment.

  The anticoagulant (bypass) line 90 is connected to the blood inlet side of the filter 56 and the blood pump 20 so as to prevent excessive pressure from being applied to the filter 56 during priming. This is a line that short-circuits the line.

  The flow rate of the priming liquid flowing through the filter 56 is controlled by operating the pump.

  In the present embodiment, the replacement fluid pump 26 sends the priming solution to the filter 56, and the blood pump 20 also helps the priming solution flow out of the filter 56. There are errors and irregularities in the operation of the pump. Therefore, the magnitude of the pressure fed by the replacement fluid pump 26 is made larger than the magnitude of the pressure that the blood pump 20 sucks out. By controlling the pump in this way, the priming liquid can be allowed to flow through the filter 56 without stagnation, and the priming of the filter 56 becomes possible. Furthermore, since a positive pressure is applied to the filter 56, a negative pressure is applied to the filter 56, so that air can be prevented from being taken into the blood circuit via the hollow fiber, thereby enabling reliable priming.

  In addition, excessive pressure may be applied to the filter 56 due to pump operation errors and unevenness. Excessive pressure may cause damage to the hollow fiber of the filter 56. Therefore, by bypassing the blood circuit with a line having a large flow path resistance at the time of priming, it is possible to prevent excessive pressure from being applied to the filter 56, thereby enabling more reliable priming.

  A line having a large flow resistance can be realized by a pipe having a smaller diameter than a pipe forming another line. In addition, the anticoagulant line at the time of treatment is generally narrower than the tubes forming the other lines. Therefore, at the time of priming, by attaching a syringe pump to one end of an anticoagulant (bypass) line 90 attached to the outflow side of the recirculation chamber 60, a bypass line is made a line through which the anticoagulant flows. Can be diverted.

  Therefore, the priming of the filter 56 can be efficiently performed without further complicating the blood purification circuit, such as adding a new line for introducing an anticoagulant during blood purification.

  The first blood return line 92 is a line through which blood flows from the blood outlet of the filter 56 to the inlet of the blood return chamber 58 during the treatment.

  The second blood return line 94 is a line through which blood flows from the discharge port of the blood return chamber 58 toward the blood return side joint 70a during the treatment. As shown in the figure, the second blood return line 94 is provided with a blood return valve 34 on the way.

  The first circulation line 96 is a line through which the priming liquid flows from the blood removal side joint 68b toward the inlet of the recirculation chamber 60 during priming. This is the site removed during blood purification. For the first circulation line 96, the direction from the blood removal side joint 68b to the inlet of the recirculation chamber 60 is the forward direction.

  The second circulation line 98 is a line through which the priming solution flows from the discharge port of the recirculation chamber 60 toward the blood return side joint 70b during priming. The first circulation line 96 is a part removed during blood purification. For the second circulation line 98, the direction from the discharge port of the recirculation chamber 60 to the blood return side joint 70b is the forward direction.

  In the blood purification circuit of the present embodiment described so far, the blood circuit includes the “blood removal line”, the inside of the filter 56, the “blood return line”, the priming fluid discharge (rapid replacement fluid) line 86, And an anticoagulant (bypass) line 90.

  The “blood removal line” includes a blood removal side joint 68a, a first blood removal line 84, a rapid replacement fluid branch pipe 64, a second blood removal line 88, an anticoagulant branch pipe 66, and a third blood removal line 89. And consists of

  The “blood return line” includes a first blood return line 92, a blood return chamber 58, a second blood return line 94, and a blood return side joint 70a.

  The liquid supply circuit includes a first liquid supply pack 50, a first liquid supply line 72, a second liquid supply pack 52, a second liquid supply line 74, a replacement liquid line 82, a dialysate line 76, The outside of the filter 56, the filtrate line 78, the filtrate pack 54, and the waste liquid line 80 are comprised.

  Further, the circulation circuit includes a blood removal side joint 68b, a first circulation line 96, a recirculation chamber 60, a second circulation line 98, and a blood return side joint 70b. Such a circulation circuit corresponds to an “auxiliary circuit” recited in the claims.

  The circulation circuit is a circuit that is removed during blood purification. Therefore, for each line constituting the circulation circuit, the direction in which the priming liquid flows is defined as the forward direction.

  Further, the waste liquid tank 100 and the waste liquid tank 102 shown in the figure are tanks for storing priming liquid flowing out from the open end of the circuit at the time of priming.

  The above is the configuration of the blood purification circuit according to the present embodiment.

  Thus, in order to prime a complicated circuit, the procedure is also complicated. For this reason, manual priming not only takes time, but also causes an operational error. By providing the automatic priming mode, it is possible to reduce the trouble of the operator and the risk of operation mistakes, and it is possible to reliably perform priming for safe blood purification.

  Such an automatic priming procedure will be described with reference to FIGS.

  FIG. 3 is a diagram schematically showing the configuration of the blood purification circuit at the time of priming according to the embodiment of the present invention and the positional relationship among the pump, valve, and pressure sensor of blood purification control device 10. The arrows in this figure indicate the forward direction of each line.

  In this figure, the pressure sensor shown in FIG. 2 is omitted. Moreover, in this figure, the same number is attached | subjected about each site | part corresponding to FIG. Therefore, the description here regarding each part is abbreviate | omitted. In addition, the recirculation chamber 60 is placed sideways in this figure for the sake of simplicity, but actually, the recirculation chamber 60 is connected to the inlet side of the recirculation chamber 60 (connected to the first circulation line 96). Is attached to the blood purification control apparatus 10 so that the upper side is vertically upward.

  FIG. 4 is a diagram illustrating an automatic priming procedure executed by the blood purification control apparatus 10 when the automatic priming mode is selected in the present embodiment.

  This figure reads the automatic priming mode information 48a from the control method storage unit 48 when the mode receiving unit 16 of the blood purification control apparatus 10 receives the selection of the automatic priming mode input to the input unit 12 by the operator. The control unit 49 that executes the read automatic priming mode information 48a shows a procedure for controlling each pump and each valve included in the blood purification control apparatus 10.

  FIG. 5 is a diagram collectively showing the circuit state in each procedure during priming according to the present embodiment. Further, FIG. 6 to FIG. 15 are circuit configuration diagrams showing circuit states in respective procedures during priming.

  In the following, each procedure shown in FIG. 4 will be described, and the state of the corresponding circuit in each procedure will be described with reference to FIGS.

  In the initial state, the blood purification control device 10 is provided with a blood purification circuit in the state as shown in FIGS. 2 and 3, and the priming liquid is stored only in the first liquid supply pack 50. . Further, as shown in the initial state of FIG. 5, it is assumed that the operation of all the pumps of the blood purification control apparatus 10 is stopped and all the valves are closed.

  The control unit 49 opens the liquid supply valve 30 and the blood return valve 34 (S1). As a result, the state of the blood purification circuit is changed to the state 1 shown in FIG. 5, and the first liquid supply line 72 and the second liquid supply pack 52 are supplied with priming liquid (hereinafter, “liquid” in the explanation of the priming procedure). Is filled. The specific state of the blood purification circuit is as shown in FIG. Thus, the step of opening the blood return valve 34 is a step of opening the blood return line, and corresponds to the “fourth step” recited in the claims.

  Here, FIG. 6 is a diagram showing a state 1 among the states during priming of the blood purification circuit according to the present embodiment. In FIG. 6, a hatched portion in the circuit configuration indicates that the portion is filled with liquid, that is, a primed portion. Moreover, the part which is not hatched shows that the liquid is not yet filled, that is, the part which is not primed. In FIG. 6, the hatched valves are shown in a closed state, and the non-hatched valves are shown in an open state.

  The hatching applied to the circuit and the valve shows the same state in FIGS. Therefore, the description regarding these hatching in each figure is abbreviate | omitted.

  Furthermore, in FIG. 6, all the pumps are not hatched. This indicates that all pumps are stopped. Similarly, in FIGS. 7 to 15, the stopped pump is not hatched, and the operating pump is hatched. Since the hatching of the pump has been described here, the description in each figure is omitted.

  From here, it returns to FIG.

  The control unit 49 operates the dialysis pump 22 (S2). Thereby, the state of the blood purification circuit becomes the state 2 shown in FIG. 5, and the liquid is supplied to the second liquid supply line 74, the dialysate line 76, and the outside of the filter 56 (part constituting the liquid supply circuit). Filled. The specific state of the blood purification circuit is as shown in FIG. Thus, the step of operating the dialysis pump 22 is a step of feeding the priming solution from the dialysate inlet of the filter 56, and corresponds to the “sixth step” described in the claims.

  The control unit 49 operates the filtrate pump 24 (S3). Thereby, the state of the blood purification circuit becomes the state 3 shown in FIG. 5, and the filtrate line 78 is filled with the liquid. The specific state of the blood purification circuit is as shown in FIG. Thus, the step of operating the filtrate pump 24 is a step of sucking out the priming solution from the dialysate discharge port of the filter 56 after the priming solution is filled in the dialysis circuit portion of the filter 56 as shown in FIG. And corresponds to the “seventh step” recited in the claims.

  The control unit 49 stops the dialysis pump 22 and the filtrate pump 24, operates the replacement fluid pump 26, and closes the liquid supply valve 30 (S4). As a result, the state of the blood purification circuit becomes the state 4 shown in FIG. 5, and the replacement fluid line 82 is filled with the liquid. The specific state of the blood purification circuit is as shown in FIG. Thus, the step of operating the replacement fluid pump 26 corresponds to a “second step” recited in the claims.

  Thus, the priming liquid is filled in the liquid supply circuit excluding the filtrate pack 54. Subsequently, priming of the blood circuit is started.

  When the replacement fluid line 82 is filled with the liquid and the liquid reaches the supply inlet of the blood return chamber 58, the controller 49 opens the priming fluid discharge valve 36 (S5). As a result, the state of the blood purification circuit becomes the state 5 shown in FIG. 5, and the second blood return line 94, the second circulation line 98, the recirculation chamber 60, the first circulation line 96, and the first The blood is filled in the blood removal line 84 and the priming liquid discharge (rapid replacement liquid) line 86. The specific state of the blood purification circuit is as shown in FIG. Here, since the liquid flows in the blood return chamber 58 in the forward direction, the liquid flows into the blood return chamber 58 at this time, but sufficient priming is not performed.

  The control unit 49 operates the blood pump 20 in the direction opposite to that during blood purification, and closes the blood return valve 34 (S6). As a result, the state of the blood purification circuit is changed to the state 6 shown in FIG. 5, and the blood return chamber 58, the first blood return line 92, the inside of the filter 56 (portion constituting the blood circuit), and the third removal. The blood line 89 and the second blood removal line 88 are filled with liquid. The specific state of the blood purification circuit is as shown in FIG.

  Thus, the step of closing the blood return valve 34 is a step of closing the blood return line, and corresponds to the “first step” recited in the claims. Further, the step of operating the blood pump 20 in the direction opposite to that at the time of blood purification is a step of sucking out the priming liquid sent to the filter 56 to the blood removal line. Equivalent to.

  As shown in FIG. 11, by closing the blood return valve 34 provided in the middle of the second blood return line 94 that is a line connected to the blood return port of the blood return chamber 58, It is possible to flow the liquid in the reverse direction. Further, by closing the blood return valve 34 provided in this way, it becomes possible to flow the liquid in the reverse direction inside the filter 56.

  The blood pump 20 adjusts the flow rate of the third blood removal line 89, and the replacement fluid pump 26 adjusts the flow rate of the first blood return line 92. Thus, since the pressure applied to the inside (blood circuit portion) of the filter 56 is adjusted by the two pumps, the inside of the filter 56 can be reliably filled with the priming liquid.

  From here, it returns to description of FIG.

  After the liquid is discarded in the waste liquid tank 102, the control unit 49 stops the blood pump 20 (S7). Thereby, the state of the blood purification circuit becomes the state 7 shown in FIG. 5, and the anticoagulant (bypass) line 90 is filled with the liquid. The specific state of the blood purification circuit is as shown in FIG.

  Thus, all the blood circuit is filled with the priming solution. Subsequently, priming of the filtrate pack 54 for which priming has not been completed is started in the liquid supply circuit.

  The controller 49 stops the replacement fluid pump 26, operates the dialysis pump 22 and the filtrate pump 24, opens the blood return valve 34, and closes the priming fluid discharge valve 36 (S8). Thereby, the state of the blood purification circuit becomes the state 8 shown in FIG. 13, and the liquid is accumulated in the filtrate pack 54. Thus, the step of operating the filtrate pump 24 is a step of feeding the priming solution sucked out from the dialysate blood return port of the filter 56 to the filtrate pack 54. Is equivalent to.

  Thus, all of the blood purification circuit is filled with the priming solution.

  The control unit 49 stops the dialysis pump 22 and the filtrate pump 24, and opens the filtrate valve 32 (S9). As a result, the state of the blood purification circuit becomes the state 9 shown in FIG. 14, and a part of the liquid accumulated in the filtrate pack 54 is discarded into the waste liquid tank 100 via the waste liquid line 80. Thus, the step of opening the filtrate valve 32 corresponds to the “ninth step” recited in the claims.

  The blood purification control apparatus 10 at the time of treatment measures the amount of purified blood based on the weight of the second liquid supply pack and the weight of the filtrate pack 54. Thus, by discarding a part of the liquid in the filtrate pack 54, the balance between the weight of the second liquid supply pack 52 and the weight of the filtrate pack 54 is adjusted, so that more accurate blood purification during the treatment is performed. The quantity can be measured.

  Thus, in the blood purification circuit of the present embodiment, not only the blood circuit and the circulation circuit but also the liquid supply circuit can be filled with the priming liquid in a series of procedures. Furthermore, in a series of procedures, the balance between the weight of the second liquid supply pack 52 and the weight of the filtrate pack 54 is automatically adjusted, so that the operation burden required for the operator to prepare for the treatment is reduced. It is possible to prepare for safe treatment without spending time.

  The control unit 49 operates the blood pump 20 (S10). Thus, recirculation is performed by removing the air remaining in the circuit by circulating the priming solution in the blood circuit. FIG. 15 is a diagram showing the flow of the priming liquid in the blood circuit according to the present embodiment at the time of recirculation. As shown in FIG. 15, the priming liquid circulates in the blood circuit according to the present embodiment, so that air remaining in the circuit is trapped in the recirculation chamber 60. Such recirculation is continued until the start of the treatment. As described above, the recirculation is a step of circulating the priming liquid in a circuit having a ring shape, and corresponds to a “fifth step” recited in the claims.

  The blood purification circuit of the present invention includes a recirculation chamber in a circulation circuit for making the blood circuit into a circulation structure during priming. With such a blood purification circuit attached, recirculation, that is, circulating the priming liquid in the blood circuit, captures air remaining in the blood circuit after priming in the recirculation chamber. And can be collected. Since the circulation circuit including the recirculation chamber is removed from the blood circuit and discarded at the time of treatment, the air collected in the recirculation chamber is discarded together with the circulation circuit. Therefore, by simply providing a recirculation chamber in the circulation circuit, air remaining in the blood circuit is removed without adding a new procedure to a series of work procedures related to blood purification such as priming and treatment. be able to. Therefore, the air in the blood circuit can be removed more reliably without imposing a burden on the operator.

  Although one embodiment of the present invention has been described above, the present invention is not limited to this.

  For example, in the embodiment, the anticoagulant (bypass) line 90 which is a bypass line reduces the pressure applied to the filter 56, so that the pressure of the priming liquid flowing through the blood removal line and the priming liquid flowing through the blood return line are reduced. As an example of a line that reduces the difference in pressure between the blood flow inlet side of the filter 56 and the blood pump 20, the anticoagulant branch pipe 66 is connected to the discharge port of the recirculation chamber 60. It was.

  In order to reduce the pressure applied to the filter 56, one end of the bypass line is connected to any one of the blood removal line, the circulation line, and the blood return line, and the pressure applied to the filter 56 by the blood pump 20 and the replacement fluid pump 26 is reduced. Just let it go to the other line.

  That is, one end of the line that reduces the difference between the pressure of the priming liquid flowing through the blood removal line and the pressure of the priming liquid flowing through the blood return line is between the blood pump attachment portion and the blood inlet of the filter 56, Between the blood discharge port of the filter 56 and the blood return valve mounting portion (including the blood return chamber 58), between the replacement fluid pump 26 and the blood return chamber 58, the other end is connected to the other blood circuit. It only has to be connected.

  More specifically, first, when one end of the bypass line is connected between the blood pump attachment portion and the blood inlet of the filter 56, the other end is connected to the blood pump attachment portion and the blood removal side joint. 68a, and the other end is connected to the circulation line, connected between the blood return valve mounting portion and the blood return side joint 70a, or connected to the priming fluid discharge (rapid replacement fluid) line 86. There is a case. In this case, the embodiment of the present invention is an example in which the other end is connected to the circulation line.

  Secondly, one end of the bypass line is connected between the blood outlet of the filter 56 and the blood return valve mounting portion (including the blood return chamber 58), and the other end is connected to the blood pump mounting portion and the blood removal side. There is a case where the connection is made between the joint 68a and the other end is connected to the circulation line, and is connected between the blood return valve mounting portion and the blood return side joint 70a or to the priming fluid discharge (rapid replacement fluid) line 86. is there.

  For example, FIG. 16 is a diagram showing the configuration of a blood purification circuit according to a modification of the present invention. The anticoagulant (bypass) line 106 shown in FIG. Connected to the blood removal line 84. This modification is an example in which the other end is connected between the blood pump attachment portion and the blood removal side joint 68a in the second case.

  Third, one end of the bypass line is connected between the replacement fluid pump 26 and the blood return chamber 58, the other end is connected between the blood pump mounting portion and the blood removal side joint 68a, and the other end is It may be connected to the circulation line, connected between the blood return valve mounting portion and the blood return side joint 70a, or connected to the priming fluid discharge (rapid replacement fluid) line 86.

  Since such a bypass line can be diverted as a line for introducing an anticoagulant during the treatment, a portion suitable for the injection of the anticoagulant may be selected at one end thereof. Even with such a circuit configuration, it is possible to automatically execute priming by a series of controls without attaching and detaching the pack storing the priming solution during the treatment.

  The present invention can be applied to a blood purification control apparatus that automatically executes priming, which is preparation for purifying a patient's blood. In addition, the present invention can be applied to a blood purification control apparatus that executes recirculation for circulating a priming solution through a blood circuit during the period from completion of priming to treatment by a patient.

It is a block diagram which shows the structure of the blood purification control apparatus which concerns on one embodiment of this invention. It is a figure which shows the structure of the blood purification circuit at the time of priming which concerns on one embodiment of this invention, and the positional relationship of the pump of a blood purification control apparatus, a valve | bulb, and a pressure sensor. It is a figure which simplifies and shows the structure of the blood purification circuit at the time of priming which concerns on one embodiment of this invention, and the positional relationship of the pump of a blood purification control apparatus, a valve | bulb, and a pressure sensor. In this Embodiment, it is a figure which shows the procedure of the automatic priming which the blood purification control apparatus 10 performs, when the automatic priming mode is selected. It is a figure which shows collectively the state of the circuit in each procedure at the time of priming of this Embodiment. It is a figure which shows the state 1 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 2 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 3 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 4 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 5 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 6 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 7 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 8 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the state 9 among the states at the time of priming of the blood purification circuit which concerns on this Embodiment. It is a figure which shows the flow of the priming liquid in the blood circuit which concerns on this Embodiment at the time of recirculation. It is a figure which simplifies and shows the structure of the blood purification circuit at the time of priming which concerns on one modification of this invention, and the positional relationship of the pump of a blood purification control apparatus, a valve | bulb, and a pressure sensor.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Blood purification control apparatus 12 Input part 14 Display part 16 Mode reception part 20 Blood pump 22 Dialysis pump 24 Filtrate pump 26 Supplementary liquid pump 30 Supply valve 32 Filtrate valve 34 Return valve 36 Priming liquid discharge valve 40 Filtrate pressure sensor 42 Blood Removal Sensor 44 Inflow Pressure Sensor 46 Exhaust Pressure Sensor 48 Control Method Storage Unit 49 Control Unit 50 First Supply Pack 52 Second Supply Pack 54 Filtrate Pack 56 Filter 56 Return Chamber 60 Recirculation Chamber 62 Liquid supply branch pipe 64 Rapid replacement liquid branch pipe 66 Anticoagulation branch pipe 68a, 68b Blood removal side joint 70a, 70b Blood return side joint 72 First liquid supply line 74 Second liquid supply line 76 Dialysate line 78 Filtrate line 80 Waste liquid Line 82 Fluid replacement line 84 First blood removal line 86 Priming fluid discharge (Rapid replacement fluid) line 88 second blood removal line 89 third blood removal line 90 anticoagulant (bypass) line 92 first blood return line 94 second blood return line 96 first circulation line 98 second circulation line 100, 102 Waste liquid tank

Claims (8)

A priming method executed by a blood purification control device for a blood purification circuit having a filter for purifying blood and a blood return line connected to a blood discharge port of the filter,
A first step of closing a blood return valve provided in the blood return line;
And a second step of feeding a priming solution into the blood return line between the blood return valve and the filter. The blood purification circuit further comprises a blood removal line connected to the blood inlet of the filter,
The priming method according to claim 1, further comprising a third step of causing the priming solution sent to the filter to flow out to the blood removal line. 3. The priming method according to claim 2, wherein in the second step, the priming liquid is fed at a flow rate larger than a flow rate at which the priming liquid flows out in the third step. And a fourth step of opening the blood return line,
The priming method according to any one of claims 1 to 3, wherein the first step is executed after the second step and the fourth step. The blood purification circuit further includes an auxiliary circuit having a chamber in the middle and connecting the blood return line and the blood removal line to make the filter, the blood removal line, and the blood return line annular. Have
Furthermore, after the priming of the blood purification circuit is completed, the fifth step of circulating the priming liquid in the annular circuit by opening the blood return valve and circulating the priming liquid is included. The priming method according to any one of claims 1 to 4. The priming method according to any one of claims 1 to 5, further comprising a sixth step of flowing a priming solution from a dialysate inlet of the filter. Furthermore, after the dialysis circuit part of the said filter is filled with the priming liquid in the said 6th step, the 7th step which makes a priming liquid flow out from the dialysate discharge port of the said filter is included. The priming method described in 1. The blood purification circuit further includes a container into which the priming liquid flowing out from the dialysate discharge port of the filter, a dialysate discharge line connecting the dialysate discharge port of the filter and the container, and the container And a disposal line for discarding the priming liquid stored in
Further, an eighth step of sending the priming solution flowing out from the dialysate discharge port of the filter into the container;
And a ninth step of adjusting a remaining amount of the priming liquid in the container by discarding a part of the priming liquid sent to the container via the disposal line after the eighth step. The priming method according to claim 7.

Images