JP2007284370A - Adhesive material for body surface - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an adhesive material which exhibits a proper adhesive force through an adhering period, is good in adhesiveness to adherends such as the skins during the adhering, does not leave an adhesive on the adherends, when peeled, and is free from a problem of peeling irritation due to the increase of an adhesive force with the passage of time. <P>SOLUTION: This adhesive material for body surfaces, comprising a substrate and an adhesive layer formed on at least one side of the substrate, is characterized in that the adhesive layer comprises a silicone polymer adhesive comprising 50 to 97 wt.% of an addition reaction type silicone polymer and 3 to 50 wt.% of a condensation reaction type silicone polymer. It is preferable that the adhesive of the adhesive layer has a specific loss modulus in specific measurement conditions. The adhesive material for body surfaces is preferably useful for fixing stomas on the surfaces of bodies. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

The present invention relates to a body surface patch. More particularly, the present invention relates to a patch for body surface used in the medical field for fixing a medical material to the skin, protecting or treating skin and wounds, and beauty.
The body surface patch of the present invention is also suitable for being used on the skin or other body surfaces for home use, sports use, cosmetic use, and the like.

Sheet-like or roll-like patch materials are used for fixing medical materials such as tubes, gauze, and bandages used for treatment of diseases to the body surface, treating and protecting wounds and skin, and beauty.
Moreover, in order to fix the stoma appliance for accommodating the excretion from a human body to an abdominal part etc., the substantially circular adhesive board and the thin sheet-like sticking material stuck around the adhesive board are used.
These patch materials are composed of a base material and a pressure-sensitive adhesive layer covering the surface of the base material, and it is necessary to have flexibility and stretchability that can follow the unevenness and extension of the skin. It is required that the skin physiological functions such as sweating and insensitive steaming are not inhibited.

In order to satisfy such required performance, various studies have been made on the pressure-sensitive adhesive and the base material.
As the type of pressure-sensitive adhesive, acrylic and rubber-based pressure-sensitive adhesives are often used. However, these pressure-sensitive adhesives may cause pain and discomfort due to excessive adhesion to the adherend such as the skin and excessive peeling of the skin stratum corneum or pulling of the hair during peeling. It was.
On the other hand, the patch which uses a silicone type adhesive as an adhesive is also known (for example, patent documents 1-3). Silicone-based adhesives exhibit high adhesion to the skin and moderate adhesion and moisture permeability at the time of application, and may cause less irritation and discomfort to the skin when peeling than acrylic or rubber-based adhesives. it can. Therefore, silicone-based adhesives are considered to be suitable as adhesives for medical and household patches that are often applied to the same part of the skin multiple times in order to maintain treatment and maintain cleanliness. It is done.
However, with silicone-based adhesives, it may be difficult to obtain initial adhesive strength (tack) or sufficient adhesion to the skin or base material, and the adhesive may peel off during use, or the adhesive may be applied to the skin after peeling. Sometimes remained.

In order to improve the initial adhesive strength deficiency of such a silicone pressure-sensitive adhesive and the low adhesiveness to the skin and the substrate, it has been studied to mix a pressure-sensitive adhesive other than the silicone pressure-sensitive adhesive.
For example, Patent Document 4 discloses a pressure-sensitive adhesive tape for skin application in which an organopolysiloxane pressure-sensitive adhesive layer containing an acrylic pressure-sensitive adhesive in a predetermined ratio is provided on a nonwoven fabric made of polyurethane elastic fibers. However, this pressure-sensitive adhesive has low adhesion to the substrate, and in order to compensate for this, it is necessary to contain an inorganic filler on the substrate surface.
Patent Document 5 discloses a pressure-sensitive adhesive containing a micro layer separation structure on one side of a support containing an organosiloxane polymer and an acrylic polymer mainly composed of (meth) acrylic acid ester. A skin patch material in which layers are laminated is disclosed.
Patent Document 6 discloses a pressure-sensitive adhesive composition containing a rubber-based pressure-sensitive adhesive containing an elastomer selected from diene rubber and polyisobutylene, and a silicone-based pressure-sensitive adhesive containing organopolysiloxane. .
However, the adhesive materials disclosed in Patent Documents 5 and 6 have no problem when used in a short time, but when applied to the skin for a long time, they strongly adhere to the skin stratum corneum and hair so as to cause peeling irritation. Sometimes it sticks. This is probably because the longer the contact time between the pressure-sensitive adhesive and the adherend, the more “wetting” of the pressure-sensitive adhesive proceeds, and the pressure-sensitive adhesive force at the time of peeling increases from the initial pressure-sensitive adhesive force. In addition, these adhesive materials may cause adhesive to remain on the adherend when peeled due to phase separation between different types of adhesives.

Japanese Patent Publication No. 3-36805 Japanese Patent No. 2821475 JP-A-6-14932 Japanese Patent No. 3127965 JP-A-9-206369 Japanese Patent No. 3580510

Therefore, the object of the present invention is to exhibit an appropriate adhesive force throughout the application period, have good adhesion to the adherend such as the skin being applied, no adhesive residue on the adherend when peeled, and An object of the present invention is to provide a patch for body surface which does not have a problem of peeling stimulation due to an increase in adhesive strength.
A further object of the present invention is to provide a patch for body surface that is excellent in adhesion and followability to a body surface such as skin and does not inhibit skin physiological functions such as sweating and insensitive excretion.

  As a result of intensive studies to achieve the above-mentioned problems, the present inventor has found that the pressure-sensitive adhesive may be constituted by combining two specific silicone polymers, and completes the present invention based on this finding. It came to.

Thus, according to the present invention, there is provided a patch for body surface comprising a substrate and an adhesive layer formed on at least one surface thereof, wherein the adhesive layer comprises 50 to 97% by weight of an addition-reactive silicone polymer and A body surface patch comprising a silicone polymer pressure sensitive adhesive comprising 3 to 50% by weight of a condensation reaction type silicone polymer is provided.
In the body surface patch of the present invention, the silicone polymer pressure-sensitive adhesive is preferably composed of 80 to 97% by weight of an addition reaction type silicone polymer and 3 to 20% by weight of a condensation reaction type silicone polymer.
Moreover, in the patch for body surface of the present invention, the pressure-sensitive adhesive of the pressure-sensitive adhesive layer has a loss elastic modulus of 4,000 to 16,000 Pa and a phase difference of 25 to 40 degrees under the following condition (I), and In the following condition (II), it is preferable to have a loss elastic modulus of 300 to 850 Pa and a phase difference of 5 to 25 degrees.
Condition (I): Stress 100 Pa, Frequency 10 Hz, Measurement temperature 37 ° C.
Condition (II): Stress 100 Pa, frequency 0.01 Hz, measurement temperature 37 ° C.

In the body surface patch of the present invention, the adhesive strength to the stainless steel plate is 1.0 to 2.5 N / 25 mm and 1.0 to 3.5 N / 25 mm after 20 minutes and 24 hours, respectively. It is preferable that the increase in adhesive strength between 20 minutes after application and 24 hours after application is 0 to 1.0 N, and 1.0 to 2.0 N after 20 minutes and 24 hours after application, respectively. / 25 mm and 1.0 to 2.5 N / 25 mm, and it is more preferable that the adhesive strength increase value between 20 minutes after pasting and 24 hours after pasting is 0 to 0.7 N.
Furthermore, according to the present invention, there is provided a body surface patch comprising a substrate and an adhesive layer formed on at least one surface thereof, wherein the adhesive layer contains 50 to 97% by weight of an addition-reactive silicone polymer. And 3 to 50% by weight of a condensation reaction type silicone polymer, and the adhesive strength to the stainless steel plate is 1.0 to 2.5 N / 25 mm and 1 after 20 minutes and 24 hours, respectively. A body surface patch having a thickness of 0.0 to 3.5 N / 25 mm and an adhesive strength increase value of 0 to 1.0 N between 20 minutes after pasting and 24 hours after pasting is provided.
The body surface patch of the present invention is suitable for fixing the body surface of a stoma appliance.

The body surface patch of the present invention exhibits an appropriate adhesive force throughout the pasting period, has good adhesion to an adherend such as the skin being stuck, has no adhesive residue on the adherend when peeled, and Since there is no problem of peeling stimulation due to an increase in adhesive strength over time, it is very suitable as a body surface patch.
In addition, the body surface patch of the present invention has predetermined moisture permeability and elastic properties, so that it does not impair skin physiological functions and is excellent in adhesion and followability to the body surface such as skin. .

  The patch for body surface of the present invention is a patch for body surface comprising a substrate and an adhesive layer formed on at least one surface thereof, and the adhesive layer has an addition reaction type silicone polymer of 50 to 97 weights. % And a silicone polymer pressure sensitive adhesive comprising 3 to 50% by weight of a condensation reaction type silicone polymer.

The addition reaction type silicone polymer includes an organopolysiloxane having an alkenyl group bonded to a silicon atom (alkenyl group-containing organopolysiloxane) and an organopolysiloxane having a hydrosilyl group (Si-H) (hydrogen organopolysiloxane). This is an addition reaction (hydrosilylation reaction) using a platinum compound catalyst such as chloroplatinic acid.
The addition reaction type silicone polymer can adjust the crosslink density by changing the amount of organohydrogenpolysiloxane used for the synthesis and the amount of hydrosilyl group (Si-H) in the organohydrogenpolysiloxane molecule. it can. Thereby, the hardness and viscoelasticity of the pressure-sensitive adhesive layer used in the present invention can be easily adjusted.

In the present invention, the addition reaction type silicone polymer is preferably an addition reaction product of vinyl group-substituted polydimethylsiloxane and organohydrogenpolysiloxane.
The vinyl group-substituted polydimethylsiloxane preferably has at least two vinyl groups per molecule. The vinyl group is preferably at the terminal position of the molecule.

The condensation reaction type silicone polymer is a product obtained by condensation by dehydration or dealcoholization reaction between polyorganosiloxanes having silanol groups (Si—OH) or hydrolyzable alkoxysilyl groups (Si—OR) at the terminals.
In the dehydration condensation reaction between silanol groups (Si—OH), an organic acid salt such as zinc octylate, iron octylate, cobalt, tin or an amine-based catalyst is generally used, and the reaction proceeds by heating. The condensation reaction between the silanol group and the hydrolyzable alkoxysilyl group (Si-OR) proceeds at room temperature by a catalyst such as an acid, an alkali, an organic tin compound, or an organic titanium compound.

  In the present invention, as the condensation reaction type silicone polymer, a dehydration condensation reaction product of silicone rubber and silicone resin can be used. As the silicone rubber for that purpose, polydimethylsiloxane or the like whose ends are blocked with OH groups can be used. Moreover, as a silicone resin, the thing of the three-dimensional structure which consists of a monofunctional siloxane unit and a tetrafunctional siloxane unit can be used.

In the pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer of the body surface patch of the present invention, the ratio of the addition reaction type silicone polymer to the condensation reaction type silicone polymer is the addition reaction type silicone polymer / condensation reaction type silicone polymer weight ratio, It is necessary that it is 97 / 3-50 / 50, and it is preferable that it is 95 / 5-80 / 20.
If the content ratio of the addition reaction type silicone polymer is less than 50% by weight (the content ratio of the condensation reaction type silicone polymer is more than 50% by weight), the adhesive force to the skin becomes too strong, and irritation at the time of peeling occurs. There is a risk of increase.
In addition, if the content of the addition reaction type silicone polymer is more than 97% by weight (the content ratio of the condensation reaction type silicone polymer is less than 3% by weight), there is a possibility that good adhesion to the skin or the substrate cannot be obtained. is there.

In the patch for body surface of the present invention, the pressure-sensitive adhesive layer may contain a plasticizer, a filler and the like. In particular, when a silicone oil such as low molecular weight dimethylpolysiloxane, silica or the like is contained, it is easy to adjust the hardness and viscoelasticity of the pressure-sensitive adhesive layer.
Further, the pressure-sensitive adhesive layer contains other adjusters such as a drug, a surfactant, a water-absorbing polymer, a powder, a pH adjuster, an antiseptic, an antibacterial agent, and a colorant, so as not to impair the purpose of the present invention. Can be appropriately blended.
As the drug, a substance containing a substance that adjusts the physiological function of the skin for the purpose of moisturizing, preventing aging, whitening or the like, or a substance that promotes healing of wounds can be used. Specific examples thereof include sodium hyaluronate, amino acid, hydrolyzed peptide, urea, ceramide, vitamins, coenzyme Q10, soybean isoflavone, polyphenol and the like.
In particular, a body surface patch having a pressure-sensitive adhesive layer containing a water-absorbing polymer is stuck on a wound dressing, an adhesive plate (face plate) for fixing a stoma device to the body surface such as the abdomen, or the periphery of these. It can be suitably used as a patch. These body surface patches exhibit good adhesion even in the surrounding area of the wound or stoma from which exudate or drainage is discharged, and facilitate hygiene management of the application site. However, when the adhesive for body surface of the present invention is used as an adhesive to be applied around the stoma device adhesive plate, the amount of exudate absorbed is not so much, so it is used without adding a water-absorbing polymer. The top has sufficient tackiness and durability.

  In the patch for body surface of the present invention, the pressure-sensitive adhesive layer preferably has a thickness of 10 to 500 μm, and more preferably 10 to 200 μm. When the thickness of the pressure-sensitive adhesive layer is within this range, an appropriate adhesive force is exhibited at the time of sticking, the adhesiveness to the body surface and followability are excellent, and good moisture permeability can be obtained.

  The surface hardness (A) of the pressure-sensitive adhesive layer is preferably 20 or less, and more preferably 1 or less. When the surface hardness (A) of the pressure-sensitive adhesive layer is 20 or less, the body surface patch well follows the skin extension, and does not give a sense of incongruity or physical irritation during application to the skin. No pain or discomfort occurs when the adhesive patch is peeled off.

In the present invention, the pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer has a loss elastic modulus of 4,000 to 16,000 Pa and a phase difference of 25 to 40 degrees under the following condition (I), and the following condition (II) It is preferable to have a loss elastic modulus of 300 to 850 Pa and a phase difference of 5 to 25 degrees.
Condition (I): Stress 100 Pa, Frequency 10 Hz, Measurement temperature 37 ° C.
Condition (II): Stress 100 Pa, frequency 0.01 Hz, measurement temperature 37 ° C.
The loss elastic modulus is an index of the hardness and softness of the pressure-sensitive adhesive, and the phase difference is an index of the balance between the viscosity and elasticity of the pressure-sensitive adhesive.
When the loss elastic modulus is smaller than 4,000 Pa and the phase difference is larger than 40 degrees in the above condition (I), deviation or deformation from the sticking position and adhesive residue at the time of peeling easily occur, and the loss elastic modulus is 16,000 Pa. If it is larger and the phase difference is less than 25 degrees, it is difficult to obtain a good initial adhesive force (tack) at the time of application, and excessive stress may be easily applied to the application site at the time of peeling.
Further, when the loss elastic modulus is smaller than 300 Pa and the phase difference is larger than 25 degrees in the above condition (II), the cohesiveness is lowered and cold flow (deformation and sag during storage) and the shape retention of the adhesive layer are lowered. If the loss elastic modulus is greater than 850 Pa and the phase difference is less than 5 degrees, the wettability to the adherend may be reduced.
In this invention, it is preferable that the loss elastic modulus in the said conditions (I) is 4,000-10,000Pa, and it is preferable that the said phase difference is 25-35.
Moreover, it is preferable that the loss elastic modulus in the said conditions (II) is 300-700 Pa, and it is preferable that the said phase difference is 5-20.

If the base material used for the adhesive for body surfaces of this invention is conventionally used in this field | area, it will not be specifically limited.
The material may be any of synthetic resin, paper, fiber and the like. In addition, the form of the substrate may be any of a film, a foam sheet, a nonwoven fabric, a woven fabric, a knitted fabric, etc., but a film is preferable from the viewpoint of controlling the coating thickness.
One of these substrates may be used alone, or a substrate having a laminated structure in which substrates of the same or different types are laminated.
The substrate is preferably liquid impermeable. By using a liquid-impermeable base material, even when a low-viscosity adhesive is applied, the adhesive will penetrate to the side opposite to the surface on which the adhesive layer of the base material is to be formed. Can be prevented.

The material of the synthetic resin film used as a base material includes polyesters such as polyethylene terephthalate and polybutylene terephthalate and polyester-based thermoplastic elastomers; polyolefins such as polyethylene and polypropylene, and olefin-based thermoplastic elastomers; ethylene / vinyl acetate copolymer (EVA) ), Ethylene / ethyl acrylate copolymer (EEA), ethylene / methyl acrylate copolymer (EMA), ethylene / methyl methacrylate copolymer (EMMA), ethylene / methacrylic acid polymer (EMAA), ethylene / acrylic acid copolymer Examples thereof include olefin copolymers such as polymers (EAA); polyamides such as nylon 6 and nylon 66; polystyrene and styrene thermoplastic elastomers; silicones, and the like. Among these, a polyester-based thermoplastic elastomer is preferable, and a polyether / polyester block copolymer and / or a copolymer having a polyester / polyester block copolymer as a main component can be used as a suitable material.
These materials may be used alone or in combination of two or more.
Antioxidants, antistatic agents, inorganic fillers, lubricants, pigments, dyes, and the like can be added to these synthetic resins as long as the object of the present invention is not impaired.

Non-woven fabric formed from polyester fiber, polyolefin fiber, polyamide fiber, polyacrylonitrile fiber, polyurethane fiber, polyvinyl alcohol fiber, polyvinyl chloride fiber, polyvinylidene chloride fiber, etc. Knitted fabric or woven fabric.
Examples of the foam sheet include closed-cell or open-cell foam sheets formed from polyurethane, polyolefin, natural or synthetic rubber, acrylic, silicone, and the like.
As the paper, high-quality paper, kraft paper, glassine paper, coated paper and the like can be used.

  In the present invention, the thickness of the substrate is preferably 15 to 1,000 μm. When the synthetic resin film is used alone, the thickness is preferably 15 to 150 μm, and more preferably 20 to 100 μm.

  In the present invention, the elongation percentage of the substrate is preferably 40 to 1,500%. If the elongation percentage of the base material is less than the above lower limit, the base material may not easily follow the extension of the skin and may cause a sense of incongruity during application, and the buffering ability against stress from the outside or the skin may also be reduced. . On the other hand, if the elongation percentage of the base material is larger than the above upper limit, the base material may be easily wrinkled or twisted during use.

In the present invention, the basis weight of the substrate is preferably 10 to 150 g / ^{m 2,} and still more preferably from 10 to 100 g / ^{m 2.} If the basis weight is lower than 10 g / m ² , the strength of the base material is not sufficient, and there is a possibility that it will be broken by repeated friction during use. On the other hand, if the basis weight is higher than 150 g / m ² , it becomes bulky and uncomfortable when applied to the skin, and the followability to a curved surface portion may be deteriorated.
The base material is preferably moisture permeable and stretchable so as not to disturb the physiological function of the skin.

  In the patch for body surface of the present invention, the pressure-sensitive adhesive layer may be on at least one surface of the substrate, but the pressure-sensitive adhesive layer may be formed on both surfaces of the substrate. The body surface patch provided with the pressure-sensitive adhesive layer on both sides can be used, for example, when a tube such as a catheter is fixed on the skin. In this case, if one surface of the adhesive layer is affixed to the skin, a tube is placed on the other surface, and an adhesive material provided with an adhesive layer on one surface is covered from above the tube, the tube is firmly fixed. be able to.

The body surface patch is produced by applying an adhesive containing an addition reaction type silicone polymer and a condensation reaction type silicone polymer in a predetermined ratio to a substrate, and then curing the adhesive to form a base. A method of forming an adhesive layer on the material can be used.
In addition, as a method for producing a body surface patch, there is also a method in which a pressure-sensitive adhesive is applied to a release sheet, then the pressure-sensitive adhesive is cured, and this is transferred to a base material to form a pressure-sensitive adhesive layer on the base material. Can be used.
At this time, as the release sheet, a release paper treated with a silicone-based release agent, fluorine, a fluorine compound, or the like, a release film, or the like can be used.

The method of applying the adhesive to the base material or release sheet is not particularly limited, and the coating pattern and thickness are controlled using a known coating method such as comma direct, knife coater, or gravure direct. Can do.
As the coating pattern of the pressure-sensitive adhesive layer, the surface of the base material may be partially covered, or the entire surface may be covered, and any form such as a lattice shape, a net shape, a granular shape, or an arabesque pattern is selected. it can.
In the patch for body surface of the present invention, surface treatment or primer treatment may be applied to the substrate in order to improve the adhesion between the substrate and the pressure-sensitive adhesive layer. Examples of the surface treatment of the substrate include embossing, sand mat processing, corona discharge treatment, plasma treatment, and alkali treatment.
Thus, the body surface patch of the present invention comprising the substrate and the pressure-sensitive adhesive layer formed on at least one surface thereof can be obtained.

The adhesive material for body surface of the present invention has an adhesive strength to the stainless steel plate of 1.0 to 2.5 N / 25 mm and 1.0 to 3.5 N / 25 mm after 20 minutes and 24 hours, respectively. In addition, it is preferable that the adhesive strength increase value from 0 minutes after pasting to 24 hours after pasting is 0 to 1.0N.
The adhesive strength to the stainless steel plate is 1.0 to 2.0 N / 25 mm and 1.0 to 2.5 N / 25 mm after 20 minutes and 24 hours, respectively, and 24 hours after application 20 minutes. It is more preferable that the adhesive strength increase value in the later period is 0 to 0.7N.
When the adhesive strength to the stainless steel plate is within this range, the patch does not peel off during use, or excessive peeling of the stratum corneum or hair pulling does not occur during peeling.

  The patch for body surface of the present invention preferably has a tensile load at 40% displacement of 10.0 N / 25 mm or less, particularly preferably in the range of 1.0 to 10.0 N / 25 mm. When the tensile load at 40% displacement is 10.0 N / 25 mm or less, the patch for body surface of the present invention follows the extension of the skin well and gives a sense of incongruity and physical irritation during application to the skin. There is nothing. When the thickness is less than 1.0 N / 25 mm, the body surface patch becomes easier to wrinkle and may be difficult to handle at the time of sticking.

The body surface patch of the present invention preferably has a moisture permeability of 300 g / m ² · 24 hours or more, and more preferably has a moisture permeability of 500 g / m ² · 24 hours or more. When the moisture permeability is 300 g / m ² · 24 hours or more, the physiological function of the skin is suitably maintained.

The form of the patch for body surface of the present invention is not particularly limited, and is a polygon such as a triangle, a quadrangle, or a rhombus, a circle, an ellipse, or a sheet-like form obtained by appropriately combining these forms, or a specific direction. A roll-like form produced continuously can be used.
Moreover, in order to protect an adhesive layer, you may provide the protective layer which can be peeled on the surface of an adhesive layer depending on necessity. As the protective layer, a film made of polyester, polyethylene, polypropylene or the like, a film subjected to a release treatment with a silicone-based release agent, fluorine, a fluorine compound, or the like, or paper can be used. Moreover, you may provide unevenness, such as embossing, in these protective films.
Moreover, even without providing a protective layer, the adhesive layer of the continuously produced patch is temporarily attached to the back surface of the base material (the side opposite to the side where the adhesive layer of the base material is present), It can also be in the form of a roll.

The body surface patch of the present invention can be suitably used for fixing the body surface of a stoma appliance.
When the body surface patch of the present invention is used for fixing the body surface of a stoma device, a pouch for containing excreta is deposited on the back surface (the side without the adhesive layer) of the base material of the patch material by welding or the like. It may be fixed, or an adhesive patch of the present invention having an annular shape may be installed around an adhesive plate (face plate) of a ready-made stoma device.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited to these. In addition, the part and% in each example are mass references | standards unless there is particular notice. Each characteristic of the patch for body surface was measured by the following method.

[Moisture permeability]
The moisture permeability of the patch for body surface is measured when measured according to JIS L 1099-1993 A-2 “Water Method”. At the time of measurement, the pressure-sensitive adhesive layer of the body surface patch is placed facing the water side of the moisture permeable cup. The higher this value, the better the moisture permeability.

[Surface hardness (A)]
A test piece having a thickness of 6.0 mm or more is prepared from the pressure-sensitive adhesive (composition) for forming the pressure-sensitive adhesive layer, and a type A durometer is used according to JIS K 6253-1997 “Durometer Hardness Test”. taking measurement.

[Tensile load at 40% displacement]
According to JIS Z 0237 “Tensile strength and elongation”, the load (N / 25 mm) at the time of 40% displacement of the body surface patch is measured. This numerical value is preferably 10.0 N / 25 mm or less.

〔Adhesive force〕
The adhesive strength (N / 25 mm) of the body surface patch is measured according to JIS Z 0237-2000 “180 degree peeling adhesive strength”. A stainless steel plate is used as the adherend. The adhesive strength is measured 20 minutes and 24 hours after the test pieces of Examples and Comparative Examples are attached to the stainless steel plate.

[Skin application test]
A test piece of a body surface patch adjusted to a width of 25 mm and a length of 75 mm is affixed to the back skin of five subjects, and the test piece is confirmed to float or peel from the skin after 24 hours (○: float)・ No peeling, x: floating / peeling). Also check for the presence of glue residue on the skin.
In addition, when peeled in the direction of 180 degrees at a speed of 1,000 mm / min after 24 hours, the pain at the time of peeling is divided into 5 levels (5: feel no pain-3: feel pain-1: strong I feel pain). A larger number means that no pain is felt during peeling.

[Loss modulus and phase difference]
Three test pieces having a diameter of 20 mm are prepared from the pressure-sensitive adhesive layer before the substrates are bonded. Using a rotary rheometer (manufactured by HAAKE, trade name “Rheostress RS150”), the oscillation is measured under the measurement conditions of a measurement temperature of 37 ° C. and a shear stress of 100 Pa, and the loss at frequencies of 10 Hz and 0.01 Hz. Measure the elastic modulus and phase difference.

[Example 1]
95 parts by weight of a two-component addition-reactive silicone polymer (manufactured by Dow Corning, trade name “DOW CORNING 7-9800”) mainly composed of vinyl group-substituted polydimethylsiloxane, organohydrogenpolysiloxane, and platinum catalyst, and silicone 8 parts by weight (ethyl acetate solvent, solid content 5 parts by weight) of a condensation reaction-type silicone polymer (trade name “DOW CORNING MD7-4502” manufactured by Dow Corning Co., Ltd.) obtained by dehydration condensation reaction of rubber and silicone resin Mixed.
This mixed solution was applied to a silicone release sheet and cured by heating at 110 ° C. for 3 minutes to form a pressure-sensitive adhesive layer having a thickness of 70 μm. Next, this pressure-sensitive adhesive layer was formed by laminating a polyester elastomer film composed of a polyether / polyester block copolymer and a polyester elastomer nonwoven fabric composed of a polyether / polyester block copolymer (weight per unit area: 70 g / m ^2). ) Was transferred to the film side to obtain a body surface patch. Table 1 shows the results of evaluating the characteristics of this patch for body surface.

[Examples 2-3]
A patch for body surface was obtained in the same manner as in Example 1 except that the ratio of the addition reaction type silicone polymer and the condensation reaction type silicone polymer constituting the pressure-sensitive adhesive layer was changed. Table 1 shows the results of evaluating the characteristics of this patch for body surface.

[Comparative Example 1]
The pressure-sensitive adhesive layer is a two-component addition-reaction silicone polymer mainly composed of vinyl group-substituted polydimethylsiloxane, organohydrogenpolysiloxane, and platinum catalyst (Dow Corning, trade name “DOW CORNING 7-9800”) 100. A patch for body surface was obtained in the same manner as in Example 1 except that only the parts by weight were used. Table 1 shows the results of evaluating the characteristics of this patch for body surface. In addition, since the adhesive of Comparative Example 1 was difficult to adhere to the substrate, the substrate was subjected to primer treatment with a silicone resin.

[Comparative Example 2]
A patch for body surface was obtained in the same manner as in Example 1 except that the ratio of the addition reaction type silicone polymer and the condensation reaction type silicone polymer constituting the pressure-sensitive adhesive layer was changed. Table 1 shows the results of evaluating the characteristics of this patch for body surface.

[Comparative Example 3]
2-ethylhexyl acrylate in 90 parts by weight of a two-component silicone mainly composed of vinyl group-substituted polydimethylsiloxane, organohydrogenpolysiloxane, and platinum catalyst (trade name “DOW CORNING 7-9800” manufactured by Dow Corning) An acrylic copolymer obtained by solution polymerization of a monomer mixture consisting of parts by weight, 70 parts by weight of butyl acrylate, 5 parts by weight of acrylic acid, and 5 parts by weight of N-dimethylacrylamide in ethyl acetate and toluene. A solution containing 20 parts by weight (10 parts by weight in terms of solid content) was added and mixed. A patch for body surface was obtained in the same manner as in Example 1 except that this mixed solution was used as a mixed solution for forming an adhesive layer. Table 1 shows the results of evaluating the characteristics of this patch for body surface.
In addition, since the adhesive of Comparative Example 3 was difficult to adhere to the substrate, the substrate was subjected to primer treatment with a silicone resin.

From the results in Table 1, the following can be understood.
In Comparative Example 1 in which the pressure-sensitive adhesive layer was formed only from the addition reaction type silicone polymer, the adhesive strength was low, and the occurrence of floating / peeling upon skin application was observed. Moreover, the adhesiveness to a base material was low and the primer process to a base material was required.
In Comparative Example 2 in which the ratio of the addition reaction type silicone polymer and the condensation reaction type silicone polymer was outside the range defined in the present invention, the adhesive strength increased considerably over time. Moreover, the pain at the time of peeling became large.
In Comparative Example 3 in which an acrylic copolymer was used in place of the condensation reaction type silicone polymer and this was used in combination with the addition reaction type silicone polymer, the acrylic dispersed in the silicone polymer was measured during the adhesive force measurement and the skin patch test. The particles of the system copolymer pressure-sensitive adhesive remained in the form of dots on the adherend stainless steel plate and the skin, and sufficient adhesive strength was not obtained. Moreover, the adhesiveness to a base material was low and the primer process to a base material was required.
On the other hand, the body surface patch of the present invention using addition reaction type silicone and condensation reaction type silicone in a predetermined ratio has good adhesion to the substrate, improved adhesive force, and floats when stuck.・ There is no peeling or adhesive residue, and there is no pain when peeling.

Claims (7)

  A body surface patch comprising a substrate and a pressure-sensitive adhesive layer formed on at least one surface thereof, wherein the pressure-sensitive adhesive layer comprises an addition reaction type silicone polymer of 50 to 97% by weight and a condensation reaction type silicone polymer of 3 to 50 A patch for body surface comprising a silicone polymer pressure-sensitive adhesive consisting of% by weight.   2. The body surface patch according to claim 1, wherein the silicone polymer pressure-sensitive adhesive comprises 80 to 97% by weight of an addition reaction type silicone polymer and 3 to 20% by weight of a condensation reaction type silicone polymer. The pressure-sensitive adhesive of the pressure-sensitive adhesive layer has a loss elastic modulus of 4,000 to 16,000 Pa and a phase difference of 25 to 40 degrees under the following condition (I), and a loss of 300 to 850 Pa under the following condition (II) The patch for body surface according to claim 1 or 2, which has an elastic modulus and a phase difference of 5 to 25 degrees.
Condition (I): Stress 100 Pa, Frequency 10 Hz, Measurement temperature 37 ° C.
Condition (II): Stress 100 Pa, frequency 0.01 Hz, measurement temperature 37 ° C.   The adhesive strength to the stainless steel plate is 1.0 to 2.5 N / 25 mm and 1.0 to 3.5 N / 25 mm after 20 minutes and 24 hours, respectively, and from 20 minutes to 24 hours after application. The adhesive material for body surface according to any one of claims 1 to 3, wherein the adhesive strength increase value between is between 0 and 1.0N.   The adhesive strength to the stainless steel plate is 1.0 to 2.0 N / 25 mm and 1.0 to 2.5 N / 25 mm after 20 minutes and 24 hours, respectively, and from 20 minutes to 24 hours after application. The adhesive material for body surface according to claim 4, wherein the adhesive strength increase value between is between 0 and 0.7 N.   A body surface patch comprising a substrate and an adhesive layer formed on at least one surface thereof, wherein the adhesive layer comprises 50 to 97% by weight of an addition reaction type silicone polymer and 3 of a condensation reaction type silicone polymer. The adhesive strength to the stainless steel plate is 1.0 to 2.5 N / 25 mm and 1.0 to 3.5 N / 25 mm after 20 minutes and 24 hours, respectively. A patch for body surface having an adhesive strength increase value of 0 to 1.0 N between 20 minutes after application and 24 hours after application.   The patch for body surface according to any one of claims 1 to 6, which is used for fixing a body surface of a stoma appliance.