JP2007282928A5 - - Google Patents

Description

Extracorporeal circuit, method for confirming connection state between pressure measurement line and pressure measuring device, and extracorporeal circulation device

  The present invention relates to an extracorporeal circuit having a pressure measurement line, a method for confirming a connection state between a pressure measurement line and a pressure measurement means using the circuit, and an extracorporeal circulation device for carrying out this method.

  In body fluid purification treatment by extracorporeal circulation, prior to treatment, the body fluid treatment device and each circuit are connected to the body fluid purification device body, and the pressure measurement line end of the extracorporeal circulation circuit and the pressure measurement means are directly connected via a sterilization filter. To do. After this work, for example, by monitoring the pressure of a specific part in the circuit, the flow state of the liquid flow path can be known, so it is possible to detect the presence or absence of clogging and the occurrence site. However, if there is a connection failure between the circuit and the body fluid treatment device or the pressure measurement line and the pressure measurement unit, the pressure in the circuit cannot be measured correctly, and there is a possibility that it cannot be operated under a predetermined condition.

  Thus, several methods for detecting a connection failure have been studied. For example, Patent Document 1 discloses a method for detecting a mounting failure of a sterilization filter by applying pressure to a pressure measurement line using a roller pump of a blood circuit. Patent Document 2 discloses a method of detecting a connection failure by applying pressure with an air pump provided in the pressure measurement line. Further, Patent Document 3 discloses a method of detecting a connection failure by applying pressure with a drop.

Japanese Patent Laid-Open No. 02-289259 JP 2002-095741 A JP 2005-218709 A

  However, in any of the methods disclosed in Patent Documents 1, 2, and 3 described above, if a connection failure occurs, the extracorporeal circuit including the pressure measurement line has an atmospheric pressure, and thus it is difficult to identify a connection failure point. In addition, when the end of the pressure measurement line and the pressure measuring means are connected via a sterilization filter, air inside the extracorporeal circuit is lost from the end of the sterilization filter when the connection is poor. There was a possibility that the sterilization filter might get wet. Once the sterilization filter gets wet, it is difficult to regenerate and it is necessary to replace it. However, it is necessary to cut the pressure measurement line at that time, and aseptic connection becomes difficult. There was a problem that careful attention and skill were required.

  The present invention solves the above-mentioned problems, and the object of the present invention is to connect the pressure measurement line so that the sterilization filter does not get wet when the connection of the pressure measurement line is poor, and the operation and detection are simple. To provide a state confirmation method and a connection failure detection method, an extracorporeal circuit suitable for carrying out this method, and an extracorporeal circulation device suitable for carrying out a pressure measurement line connection confirmation method. To do.

  As a result of repeated investigations to solve the above problems, the present inventors usually have an extracorporeal circuit internal pressure at the time of poor connection, so if the extracorporeal circuit internal pressure at the time of poor connection can be maintained, We thought that a connection failure could be easily detected, and devised an extracorporeal circuit for carrying out this, and confirmed that the above estimation was correct by using this circuit. In other words, if the end of the pressure measurement line of the extracorporeal circuit is connected to the pressure measurement means via a connector with a valve that opens only when the connection is made, the connection between the pressure measurement line and the pressure measurement means can be easily connected. The present invention has been completed by discovering that the sterilization filter is not wetted when the connection is poor.

  That is, the first configuration of the extracorporeal circuit according to the present invention for achieving the above object is an extracorporeal circuit having at least two or more pressure measurement lines, and the pressure measurement means of the pressure measurement line It has the connector with a valve which opens a valve only at the time of a connection at the connection side terminal, The sterilization filter is connected to the circuit side of the said connector with a valve, It is characterized by the above-mentioned.

Further, in the second configuration of the extracorporeal circuit according to the present invention, a pressure measurement line having a deforming portion that isolates bodily fluid and air and deforms by the pressure in the circuit is connected to the extracorporeal circuit of the first configuration. It is characterized by being.

  In addition, the method for confirming the connection state between the pressure measurement line and the pressure measurement unit according to the present invention is a method for confirming the connection state between the pressure measurement line and the pressure measurement unit in the extracorporeal circuit having the first and second configurations. The pressure measurement line is connected to the pressure measurement means, and when pressure fluctuation is detected by the pressure measurement means when the inside of the extracorporeal circuit is pressurized or depressurized, the pressure measurement line and the pressure measurement are detected. The connection between the pressure measurement line and the pressure measurement means is not detected when the pressure measurement means does not detect a change in pressure even though the connection of the means is detected as good and the pressure measurement means does not detect the pressure in the extracorporeal circuit. It is characterized by detecting a failure.

  The extracorporeal circulation apparatus according to the present invention includes at least the extracorporeal circulation circuit having the first and second configurations, pressure adjusting means for pressurizing or depressurizing the extracorporeal circulation circuit, and the pressure in the extracorporeal circulation circuit. Pressure measuring means for detecting, and alarm means for notifying that there is no pressure fluctuation when pressure fluctuation is not detected by the pressure measuring means in spite of being pressurized or depressurized in the extracorporeal circuit by the pressure adjusting means It is characterized by having.

  According to the present invention, by pressurizing or depressurizing the inside of the extracorporeal circuit, the connection state between the pressure measuring line connected to the extracorporeal circuit and the pressure measuring means can be confirmed, and a connection failure point can be detected. Furthermore, since the valve-equipped connector that opens the valve only at the time of connection is provided at the end of the pressure measurement line, the sterilization filter does not get wet when the pressure measurement line and the pressure measurement means are poorly connected.

  An embodiment of an extracorporeal circuit according to the present invention, a method for confirming a connection state between a pressure measurement line and a pressure measuring means, and an extracorporeal circulation apparatus according to the present invention will be described in detail. FIG. 1 is a schematic diagram showing an example when the extracorporeal circulation apparatus according to the present invention is used for blood adsorption therapy, and FIG. 2 is a schematic diagram showing an example when the extracorporeal circulation apparatus according to the present invention is configured as a hemodialysis apparatus. 3 is a schematic diagram showing another example when the extracorporeal circulation apparatus according to the present invention is configured as a hemodialysis apparatus, and FIG. 4 is still another example when the extracorporeal circulation apparatus according to the present invention is configured as a hemodialysis apparatus. It is a schematic diagram shown.

  A typical configuration of the connection failure detection method for the extracorporeal circulation circuit in the extracorporeal circulation device according to the present invention includes at least two pressure measurement lines in the method for detecting a connection failure portion of the extracorporeal circulation circuit in the body fluid purification device. A plurality of pressure measuring lines connected to the extracorporeal circuit and having a valve-equipped connector that opens only when connected to the end of the pressure measuring line connected to the pressure measuring means, and a plurality of pressure measuring lines connected to the end of the pressure measuring line It has a pressure measuring means and a mechanism of a pressure adjusting means for pressurizing or depressurizing the inside of the extracorporeal circuit, and the pressure inside the extracorporeal circuit is detected by each of the pressure measuring means.

  As a result, it is possible to detect a connection failure location between the pressure measurement line and the pressure measurement means. In addition, when the connection failure between the pressure measurement line and the pressure measurement means occurs, the sterilization filter does not get wet.

  The body fluid referred to in the present invention refers to blood, plasma, lymph, ascites, urine and the like.

  The extracorporeal circuit as used in the present invention refers to a conduit for circulating a therapeutic fluid such as a body fluid or a dialysis fluid, and includes hemofiltration therapy, hemodialysis therapy, hemofiltration dialysis therapy, sustained slow hemodialysis therapy, continuous Slow hemofiltration therapy, continuous slow hemofiltration dialysis therapy, plasma exchange therapy, plasma adsorption therapy, double filtration plasma exchange therapy, blood adsorption therapy, blood cell component removal therapy, ascites filtration concentrated reinfusion therapy, percutaneous cardiopulmonary A circuit used in extracorporeal circulation therapy such as support.

  For the material of the extracorporeal circuit, vinyl chloride, silicon rubber, olefin resin, etc. can be used, and among them, soft vinyl chloride is preferred. This circuit has a chamber (sometimes called "drip chamber"), pump tube, connector, three-way stopcock, branch tube for pressure measurement, anticoagulant injection connection port, replacement fluid connection port, priming solution connection port, filtrate Parts such as a discharge tube, a temporary body fluid storage container, an external clamp, a body fluid sampling port, and the like can be attached as necessary.

  The extracorporeal circulation device referred to in the present invention is a blood filtration device, hemodialysis device, hemofiltration dialysis device, continuous slow hemodialysis device, continuous slow hemofiltration device, continuous slow hemofiltration dialysis device, plasma exchange device, plasma It refers to extracorporeal circulation devices such as adsorption devices, double filtration plasma exchange devices, blood adsorption devices, blood cell component removal devices, ascites filtration concentration reinfusion devices, and percutaneous cardiopulmonary assistance.

The pressure measurement line referred to in the present invention branches from a main tube responsible for the circulation of body fluid or a non-body fluid tube responsible for the treatment fluid such as dialysate in contact with the body fluid. Any means can be used as long as it can branch through parts such as a character tube, a cross tube, a three-way stopcock, and a drip chamber, and can branch from an extracorporeal circuit. Examples of pressure measurement lines in the extracorporeal circuit for body fluid include an arterial pressure measurement line, a venous pressure measurement line, a blood pressure collection measurement line , a filtration pressure measurement line, a plasma pressure measurement line, and a plasma inlet pressure measurement line.

  The valve-equipped connector used only in the connection of the present invention is such that the valve opens when the connecting part of the pressure measuring means is correctly connected, and the pressure measuring line and the pressure measuring means communicate incompletely. When the pressure measurement line and the pressure measurement means are not connected, the valve is closed and the end of the pressure measurement line is a valve in which fluid cannot flow. Illustrative examples include connectors such as Terumo's Sure Plug (SP-1S).

  The pressure measuring means in the present invention is a means for detecting the pressure in the extracorporeal circuit and means a pressure of about −500 mmHg to 500 mmHg, such as a bourdoncan pressure gauge, manometer, semiconductor pressure sensor, etc. It can be illustrated. Among them, the semiconductor pressure sensor can obtain pressure data as an electrical output and is easy to use because it can easily control the alarm means. The pressure measuring means in the extracorporeal circuit includes an arterial pressure measuring unit, a venous pressure measuring unit, a non-blood side pressure measuring unit, and the like.

  The pressure adjusting means in the present invention means means for pressurizing or depressurizing the extracorporeal circuit, and examples thereof include an air pump, a rotary tube pump (roller pump), and a head, but are not limited thereto. It is not something. Especially, since there is no attachment of equipment unnecessary for treatment, it is preferable to use a rotary tube pump generally used in a body fluid purification device. The pressure adjusting means in the extracorporeal circuit for body fluid is a blood pump or the like.

  The sterilization filter referred to in the present invention is a filter used to prevent contamination of germs in the extracorporeal circuit, and has a pore size of 0.45 μm or less, preferably 0.3 μm or less, more preferably 0.22 μm or less. Use a membrane filter. In order to prevent the pressure measuring means from being wetted and damaged by the liquid in the extracorporeal circuit, it is preferable to use a hydrophobic membrane filter having high gas permeability. Since the hydrophobic membrane has the property of preventing the aqueous liquid from passing through, the pressure measuring means can be prevented from getting wet and broken. Such a sterilization filter is connected to the circuit side of the connector with valve.

  In the present invention, a pressure sensor (hereinafter referred to as “diaphragm pressure sensor”) that separates a body fluid from air is used to prevent contact between the body fluid and air. Pressure can be measured by separating the body fluid and the air by the deformable portion).

  This diaphragm type pressure sensor divides the inside of a sealed container into a body fluid chamber and an air chamber by a diaphragm, and connects an extracorporeal circuit so that the body fluid flows through the body fluid chamber, and the air pressure in the air chamber It has a structure that can measure. The container type of the diaphragm type pressure sensor has various shapes such as a spherical shape, a cylindrical shape, etc., and the material is preferably biocompatible and rigid. Vinyl chloride, hard vinyl chloride, polycarbonate, silicone resin, polypropylene , Polyethylene, polyurethane and the like.

  Further, the shape of the diaphragm for separating the body fluid from the air has a shape such as a flat plate shape, a triangular waveform, and a sine wave, but there is no problem as long as the pressure can be measured correctly. The material of the diaphragm is biocompatible and preferably deforms flexibly with respect to pressure. Vinyl chloride, polyvinyl chloride, silicone resin, styrene thermoplastic elastomer, styrene thermoplastic elastomer compound Etc. Although it has a flat plate shape, there is no problem even if it has a triangular wave shape or a sine wave shape when viewed from the cross section, and the area and shape of the deformed portion in the deformed portion is the pressure There is no problem as long as it can be measured correctly, and there is no particular limitation.

  A pressure measurement line having a pressure sensor with a built-in diaphragm for separating body fluid and air is connected to the extracorporeal circuit.

  The body fluid treatment device as used in the present invention refers to a medical device having functions such as removing a substance to be removed from a body fluid containing blood or activating components in a body fluid containing blood. A body fluid treatment device for treating blood is called a blood treatment device. For example, an adsorber that removes pathogenic substances by adsorption (there is a type that processes whole blood and a type that processes plasma or plasma components), a plasma separator that separates blood cell-rich components and plasma (membrane type and centrifuge type) Stimulate blood cells with a plasma component separator, hemodialyzer, hemofiltration dialyzer, hemofilter, and a stimulator with a specific ligand fixed to separate high and low molecular weight substances in plasma Examples include an immunostimulator, a blood cell selective remover that removes specific blood cells in the blood, and a artificial lung that moves oxygen and carbon dioxide through the membrane.

  The alarm means in the present invention refers to a light emitting diode (LED) that visually transmits an alarm occurrence, a light emitting element such as a lamp, a monitor display, or a buzzer that audibly transmits an alarm occurrence. Any means that can notify the user of an alarm may be used.

  The alarm means according to the present invention informs that there is no pressure fluctuation when the pressure measuring means does not detect the pressure fluctuation even though the extracorporeal circuit is pressurized or depressurized by the pressure adjusting means.

  Hereinafter, the extracorporeal circuit, the method for confirming the connection state between the pressure measurement line and the pressure measuring means, and the extracorporeal circulation apparatus according to the present invention will be described with examples. The arrangement of the specific members shown below is an example for facilitating understanding, and the present invention is not limited to this.

  FIG. 1 shows an example of a blood adsorption device as one embodiment of the present invention. In FIG. 1, a blood adsorption device 20 serving as an extracorporeal circulation device includes a control unit 11a serving as a control means, a blood processing device 2 serving as a body fluid treatment device, and an artery side connected to the blood inlet side of the blood treatment device 2. It has a blood circuit 3 and a venous blood circuit 4 connected to the blood outlet side.

  The tube that serves as the blood flow path for the arterial blood circuit 3 and the venous blood circuit 4 is called a main tube. The blood treatment device 2 of the present embodiment is a blood adsorber, but may be a wet type in which the internal space is filled with a filling liquid or a dry type in which no filling liquid is filled. In addition, the blood processor 2 in this embodiment is demonstrated as a wet type.

  The arterial blood circuit 3 is provided with a blood pump 1 serving as a pressure adjusting means for pressurizing or depressurizing the extracorporeal circuit closer to the distal side than the arterial pressure measuring line 7a serving as a pressure measuring line. An arterial pressure measurement line 7a is arranged between the blood processor 2 and the arterial chamber 6a.

  A connector 9a with a valve that opens only when connected from the end side of the arterial pressure measurement line 7a, and a sterilization filter 8a that uses a hydrophobic membrane as a filtration part are arranged, and a valve that opens only when connected The connector 9a is connected to an arterial pressure measurement unit 10a serving as a pressure measurement means for detecting the pressure in the extracorporeal circuit in the control unit 11a.

  On the other hand, the venous blood circuit 4 is provided with a venous pressure measuring line 7b serving as a pressure measuring line through the venous chamber 6b in the middle thereof. A connector 9b with a valve that opens only at the time of connection from the end side of the venous pressure measurement line 7b, and a sterilization filter 8b that uses a hydrophobic membrane as a filtration part are arranged, and a valve that opens only at the time of connection is provided. The connector 9b is connected to a venous pressure measuring unit 10b serving as a pressure measuring unit in the control unit 11a.

  Although the priming fluid reservoir 12 is connected to the distal side of the venous blood circuit 4, the priming fluid reservoir 12 may be connected to the distal side of the arterial blood circuit 3.

  A valve 5 for blocking and releasing the circuit is disposed on the terminal side of the venous blood circuit 4 from the venous pressure measurement line 7b. The valve 5 is not particularly limited, but clamps other than forceps, for example, a roller clamp, a Robert clamp, a pinch valve, and the like are particularly excellent in temporarily blocking and releasing a soft blood circuit, and are preferable.

  The blood processor 2 has two connection parts for connecting the arterial blood circuit 3 and the venous blood circuit 4.

  The arteriovenous pressure measuring lines 7a and 7b, which are pressure measuring lines, are arteriovenous serving as pressure measuring means by means of connectors 9a and 9b with valves that open only when connected via hydrophobic sterilizing filters 8a and 8b, respectively. These lines are connected to the pressure measuring units 10a and 10b, respectively.

  The specifications of the arteriovenous pressure measurement lines 7a and 7b, which are pressure measurement lines, are not particularly limited, and a pressure measurement line generally used for an extracorporeal circuit may be used. For example, a soft vinyl chloride tube or silicon tube having an inner diameter of 0.5 mm to 5 mm and a wall thickness of 0.5 mm to 2 mm can withstand pressure deformation at the extracorporeal circulation level and perform accurate pressure measurement.

  The sterilization filters 8a and 8b arranged in the pressure measurement line may infiltrate a liquid such as blood into the pressure measurement unit of the blood adsorption device 20 serving as an extracorporeal circulation device or blood adsorption due to excessive pressure increase or some misoperation. It is attached to prevent germs from entering the extracorporeal circuit from the device 20.

  The arteriovenous pressure measuring lines 7a and 7b, which are pressure measuring lines, are disposed at the ends of the arteriovenous pressure measuring lines 7a and 7b and used to connect the arteriovenous pressure measuring units 10a and 10b serving as pressure measuring means. When the connectors 9a and 9b with valves that open the valve only at the time of connection are normally connected to the arteriovenous pressure measuring lines 7a and 7b as pressure measuring lines and the arteriovenous pressure measuring units 10a and 10b as pressure measuring means When the valve is opened, ventilation becomes possible, and when the connection between the arteriovenous pressure measuring lines 7a and 7b as pressure measuring lines and the arteriovenous pressure measuring units 10a and 10b as pressure measuring means is poorly connected, the valve is closed. It has a function that prevents ventilation. Therefore, it is necessary to provide a connector with a valve that can maintain hermeticity when the valve is closed.

  Although not shown, the arteriovenous pressure measuring units 10a and 10b are connected to a pressure gauge inside the main body of the blood adsorbing device 20 serving as an extracorporeal circulation device, and the measured values are displayed on the display unit of the main body. The specifications and display mechanism of the pressure gauge are not particularly limited. Further, similarly to general instrumentation equipment, a signal sound or an alarm may be sounded when the actually measured value reaches a predetermined set pressure or is out of a predetermined range.

  The above is the overall configuration of the blood adsorption device 20 serving as the extracorporeal circulation device of the present invention. However, the specifications of pumps and chambers associated with the blood circuit are not particularly limited, and are generally used in extracorporeal circulation therapy. Any may be used as long as it is used. In addition, incidental products such as anticoagulant injection circuits and sampling ports, which are naturally used in the extracorporeal circuit, are not shown, but may be appropriately arranged.

  Next, a method for confirming the connection state between the pressure measurement line and the pressure measurement means and a method for detecting a connection failure location using the blood adsorption device 20 having the above-described configuration will be described.

  As an initial state, the arterial blood circuit 3 in which the blood pump 1 serving as the pressure adjusting means is disposed is partially blocked by bringing the blood pump 1 to a stop state, and the vein side Blood circuit 4 is shut off by closing valve 5. That is, not only the valve 5 but also the blood pump 1 acts as an opening / closing means for temporarily shutting off the circuit.

  A priming solution reservoir 12 filled with physiological saline is connected to the end of the venous blood circuit 4. Further, the arteriovenous pressure measuring lines 7a and 7b serving as the arterial and venous pressure measuring lines are respectively connected to the arteriovenous pressure measuring units 10a and 10b serving as the pressure measuring means so that the pressure measurement and display can be performed. It has become.

  Thus, in the initial state, all fluid flow passages other than the arteriovenous pressure measurement lines 7a and 7b, which are pressure measurement lines, are blocked at a part thereof, and the liquid cannot be circulated. Even when the blood treatment device 2 serving as a body fluid treatment device is of a wet type, all the liquid flow paths connected to the blood treatment device 2 are blocked as described above, so that the filling liquid does not move in the circuit. .

  Even if the connection between the arteriovenous pressure measuring lines 7a and 7b serving as pressure measuring lines and the arteriovenous pressure measuring units 10a and 10b serving as pressure measuring means is disconnected, the arteriovenous pressure measuring lines 7a and 7b are arranged at the ends. Since the valved connectors 9a and 9b are closed, the liquid in the priming liquid reservoir 12 and the filling liquid in the blood treatment device 2 do not substantially move, and the sterilization filters 8a and 8b are wetted. There is nothing.

  Next, while maintaining the initial state, the blood pump 1 serving as the pressure adjusting means is pressurized or depressurized inside the circuit constituted by the blood processor 2 and the arteriovenous pressure measuring lines 7a and 7b serving as pressure measuring lines. By driving in the direction and monitoring the respective pressures by the arteriovenous pressure measuring units 10a and 10b serving as pressure measuring means, the arteriovenous pressure measuring lines 7a and 7b serving as pressure measuring lines and the arteriovenous pressure serving as pressure measuring means Detects a connection failure location with the measurement units 10a and 10b.

  That is, the pressure of the arteriovenous pressure measuring units 10a and 10b serving as a pressure measuring means having a poor connection does not increase or decrease even though the inside of the circuit is pressurized or depressurized. It can be specified.

  In addition, since the pressure of the arteriovenous pressure measuring units 10a and 10b, which are normally connected pressure measuring means, rises or falls, detecting that the pressure has reached an arbitrary set pressure enables the movement of the pressure measurement line. It can be confirmed that the venous pressure measuring lines 7a and 7b are connected to the arteriovenous pressure measuring units 10a and 10b serving as pressure measuring means.

  The set pressure for confirming that the arteriovenous pressure measuring lines 7a and 7b serving as pressure measuring lines and the arteriovenous pressure measuring units 10a and 10b serving as pressure measuring means are connected is a blood circuit, blood There is no particular limitation as long as it does not place a burden on the pump 1 or the like.

  The connection failure may be detected by a simple method in which the user reads the pressure values of the arteriovenous pressure measuring units 10a and 10b serving as the respective pressure measuring means and determines that they are within the set range. However, it may be configured to make a determination using the control 11a serving as a control means provided in the blood adsorption device 20 serving as an extracorporeal circulation device, and may be configured as a blood purification device that automatically detects a connection failure point. In that case, the set pressure or set pressure range is stored in a storage means (not shown), and the control unit 11a compares the detected pressure with the set range stored at a predetermined timing (for example, operation by the user), and makes a determination. The result is displayed on a monitor or an alarm is generated by a signal sound.

  That is, when the arteriovenous pressure measuring lines 7a and 7b serving as pressure measuring lines are connected to the arteriovenous pressure measuring units 10a and 10b serving as pressure measuring means, respectively, When the fluctuation of pressure is detected by the arteriovenous pressure measuring units 10a and 10b, the connection between the arteriovenous pressure measuring lines 7a and 7b serving as the pressure measuring line and the arteriovenous pressure measuring units 10a and 10b serving as the pressure measuring means is good. If the fluctuation of pressure is not detected by the arteriovenous pressure measuring units 10a and 10b, which are pressure measuring means, even though the inside of the extracorporeal circuit is pressurized or depressurized, the arteriovenous pressure measuring line which is a pressure measuring line The connection between 7a, 7b and the arteriovenous pressure measuring units 10a, 10b serving as pressure measuring means can be detected as defective.

  FIG. 2 is a diagram showing an example of a device configuration when the extracorporeal circulation device is a hemodialysis device. As shown in FIG. 2, a hemodialysis apparatus 21 serving as an extracorporeal circulation apparatus includes a control unit 11b serving as control means. A waste fluid circuit 15 and a dialysate supply circuit 16 are connected to the non-blood side of the blood treatment device 2 serving as a body fluid treatment device.

  The dialysate supply circuit 16 is connected to a dialysate reservoir 17 through the dialysate supply pump 14. Thus, when two non-blood side tubes are connected to the non-blood side circuit of the blood treatment device 2, the non-blood side pressure measurement line 7c, which is a pressure measurement line, cannot be directly connected to the blood treatment device 2, so that the waste liquid It is connected to a part of the circuit 15.

  Here, the discharge pump 13 is connected to the end side of the waste liquid circuit 15 with respect to the non-blood side measurement line 7c. The circuit is cut off using the drain pump 13 as an opening / closing means, the pressure is detected by the non-blood side pressure measurement line 7c, the non-blood side pressure measurement line 7c serving as the pressure measurement line, and the non-blood side pressure measurement serving as the pressure measurement means This is to determine the connection state with the unit 10c.

  The discharge pump 13 is used as pressure adjusting means, and the blood pump 1 and dialysate supply pump 14 are used as opening / closing means, or the dialysate supply pump 14 is used as pressure adjusting means, and the blood pump 1 and discharge pump 13 are used as opening / closing means. It is also possible.

  In FIG. 2, it is arranged at the end of the non-blood side pressure measurement line 7c, which is a pressure measurement line, and is used for connection between the non-blood side pressure measurement line 7c and the non-blood side pressure measurement unit 10c serving as a pressure measurement means. In the connector 9c with a valve that opens only at the time of connection, the connection between the non-blood side pressure measurement line 7c, which is a pressure measurement line, and the non-blood side pressure measurement unit 10c, which is a pressure measurement means, is normal as described above. In this case, the valve can be opened to allow ventilation, and when the connection between the non-blood side pressure measurement line 7c, which is a pressure measurement line, and the non-blood side pressure measurement unit 10c, which is a pressure measurement means, is poorly connected, the valve is closed. It has a function that prevents ventilation.

  The non-blood side pressure measurement line 7c, which is a pressure measurement line, is connected to the non-blood side pressure measurement unit 10c serving as a pressure measurement means by a connector 9c with a valve that opens only when connected via a hydrophobic sterilization filter 8c. It is a line to be connected. Other configurations are the same as those in FIG. 1 described above, and the same effects can be obtained.

  FIG. 3 is a view showing a case where the arterial chamber 6a, the arterial pressure measurement line 7a, the sterilization filter 8a, and the connector 9a with a valve are not provided in the hemodialysis apparatus 21 which is the extracorporeal circulation apparatus shown in FIG. . In this case as well, the inside of the circuit is pressurized and depressurized by any of the pressure adjusting means of the blood pump 1, the discharge pump 13 or the dialysate supply pump 14 in the same manner as described above, and the venous pressure measuring line 7b serving as the pressure measuring line The connection state of each pressure measurement line can be confirmed through the side pressure measurement line 7c, and if there is a connection failure location, that location can be detected and an alarm can be issued by the alarm means described above. Other configurations are the same as those in FIGS. 1 and 2 described above, and the same effects can be obtained.

  FIG. 4 shows a hemodialysis apparatus 21 which is the extracorporeal circulation apparatus shown in FIG. 2 and is provided with a diaphragm type pressure sensor 18 for measuring the pressure inside the circuit through the diaphragm instead of the arterial chamber 6a. It is a figure which shows the case where there is no bacteria filter 8a and the connector 9a with a valve.

  In the present embodiment, when the diaphragm type pressure sensor 18 is installed, the pressure inside the circuit can be measured through the diaphragm. Therefore, the arterial pressure measurement line 7a which is a pressure measurement line branched from the diaphragm type pressure sensor 18 and the pressure measurement The pressure inside the circuit is maintained when the connection with the arterial pressure measuring unit 10a as a means is poor. Therefore, also in this case, the connection state between the arterial pressure measurement line 7a serving as the pressure measurement line and the arterial pressure measurement unit 10a serving as the pressure measurement means can be confirmed by adjusting the pressure inside the circuit in the same manner as described above.

  In other words, even in the configuration as shown in FIG. 4, the inside of the circuit is pressurized and depressurized in the extracorporeal circuit by any of the pressure adjusting means of the blood pump 1, the discharge pump 13, or the dialysate supply pump 14, and the arterial pressure serving as a pressure measurement line The connection state of each pressure measurement line can be confirmed through the measurement line 7a, the venous pressure measurement line 7b, and the non-blood side pressure measurement line 7c, respectively. Can issue an alarm.

  In FIG. 4, the diaphragm pressure sensor 18 and the pressure measurement line branched from the diaphragm pressure sensor 18 are in the arterial blood circuit section, but the pressure branched from the diaphragm pressure sensor 18 and the diaphragm pressure sensor 18. The position of the measurement line is not limited. Other configurations are the same as those in FIGS. 1 and 2 described above, and the same effects can be obtained.

  As an application example of the present invention, it can be applied to an extracorporeal circuit having a pressure measurement line, a method for confirming the connection state between the pressure measurement line and the pressure measuring means using the circuit, and an extracorporeal circulation device for carrying out this method. .

It is a schematic diagram which shows an example in the case of using the extracorporeal circulation apparatus which concerns on this invention for blood adsorption therapy. It is a schematic diagram which shows an example at the time of comprising the extracorporeal circulation apparatus which concerns on this invention as a hemodialysis apparatus. It is a schematic diagram which shows the other example at the time of comprising the extracorporeal circulation apparatus which concerns on this invention as a hemodialysis apparatus. It is a schematic diagram which shows another example at the time of comprising the extracorporeal circulation apparatus which concerns on this invention as a hemodialysis apparatus.

1 ... Blood pump (pressure adjusting means)
2 ... Blood processor (Body fluid processor)
3 ... Arterial blood circuit 4 ... Venous blood circuit 5 ... Valve 6a ... Arterial chamber 6b ... Venous chamber 7a ... Arterial pressure measurement line (pressure measurement line)
7b ... Venous pressure measurement line (pressure measurement line)
7c ... Non-blood pressure measurement line (pressure measurement line)
8a to 8c ... sanitizing filter 9a to 9c ... connector with valve that opens only when connected
10a ... Arterial pressure measuring part (pressure measuring means)
10b ... Venous pressure measuring unit (pressure measuring means)
10c ... Non-blood side pressure measuring part (pressure measuring means)
11a, 11b ... control unit
12 ... Priming fluid reservoir
13 ... Drain pump
14 Dialysate supply pump
15 ... Waste liquid circuit
16 ... Dialysate supply circuit
17 ... Dialysate reservoir
18 ... diaphragm pressure sensor
20 ... Blood adsorption device (extracorporeal circulation device)
21 ... Hemodialysis device (extracorporeal circulation device)

Claims (4)

An extracorporeal circuit having at least two pressure measurement lines,
A valve-equipped connector that opens only when connected to the end of the pressure measuring line connected to the pressure measuring means;
An extracorporeal circulation circuit, wherein a sterilization filter is connected to the circuit side of the connector with valve. The extracorporeal circuit according to claim 1 , wherein a pressure measuring line is connected to the extracorporeal circuit to isolate a body fluid and air and to have a deforming part that deforms by the pressure in the circuit. A method for confirming a connection state between the pressure measurement line and the pressure measurement means in the extracorporeal circuit according to claim 1,
Connecting the pressure measuring line to the pressure measuring means;
When pressure fluctuation is detected by the pressure measuring means when pressurizing or depressurizing the extracorporeal circuit, the connection between the pressure measuring line and the pressure measuring means is detected as good,
A connection between the pressure measurement line and the pressure measuring means is detected as defective when the pressure measuring means does not detect a pressure fluctuation even though the inside of the extracorporeal circuit is pressurized or depressurized. The confirmation method of the connection state of the pressure measurement line and the pressure measurement means. At least the extracorporeal circuit according to claim 1 or 2,
Pressure adjusting means for pressurizing or depressurizing the extracorporeal circuit;
Pressure measuring means for detecting the pressure in the extracorporeal circuit,
An alarm means for notifying that there is no pressure fluctuation when pressure fluctuation is not detected by the pressure measuring means even though the extracorporeal circuit is pressurized or depressurized by the pressure adjusting means;
An extracorporeal circulation device comprising: