JP2007039369A - External preparation containing powder germanium - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an external preparation containing powder germanium, which reduces inhibition of cutaneous respiration by contact of the skin with a medicine applied surface, slightly causes sweatiness and increases functionality of component contained in the medicine. <P>SOLUTION: The external preparation containing powder germanium is a patch (cataplasm) 10 obtained by coating one side of a base fabric 11 with a medicine mixed with powder germanium. A medicine layer 13 containing an adhesive in properly thin width is formed in the circumference of the coated medicine layer 12 and a large number of air permeation parts (nonadhesion parts 14 of the medicine) are distributed and formed in the medicine layer 12. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a sealed powder germanium-containing external preparation such as a patch tape or a poultice containing powdered germanium.

  Conventionally, there are many transdermal absorption type external preparations such as a poultice or plaster (adhesive tape) that can provide an analgesic effect by sticking to the affected part for pain and discomfort caused by stiff shoulders, back pain, or bruise It is used. Such external preparations are widely used because they can be used easily. Recently, poultices mixed with powdered germanium (inorganic germanium, organic germanium compounds) instead of analgesics are used for the purpose of enhancing the usefulness of using germanium, such as metabolic function. This has been proposed (for example, Patent Document 1).

  Conventional poultices and plasters are generally formed by using a nonwoven fabric or a fabric with a high woven density as a base material and applying a required drug on one side thereof. And in the poultice or plaster (drug-adhesive sheet), in order to adhere to the skin surface of the affected area so as not to peel off, the periphery of the base fabric surface on which the drug layer is formed in the drug-adhesive sheet The thing of the structure which provided the adhesive layer in is known (patent document 2 etc.). Moreover, in the said external preparation, what knead | mixed the adhesive agent is generally used in order to improve the adhesiveness to the skin surface to the chemical | medical agent apply | coated to the base fabric.

Japanese Patent Application No. 2005-95549 Utility Model Registration No. 2588236

  With conventional poultices and plasters, if the poultice or plaster is applied to the affected area, the medicinal component penetrates into the body through contact with the skin and the drug, but the application area increases. It will inhibit skin respiration. About inhibition of skin respiration by this drug, since the base fabric has air permeability, it is said that so-called stuffiness hardly occurs. However, in the case of a cataplasm applied with a thick drug layer, it is difficult to ensure the breathability as expected because the viscosity of the drug layer is high due to the nature of the drug layer when the application area becomes wide. There is a problem that the skin is easily inflamed by stuffiness when it is in an attached state. Therefore, the user is required to be careful not to cause inflammation by limiting the use time to be short.

  By the way, as known from the above-mentioned Patent Document 1, an external preparation (powder) using powdered germanium is trying to achieve an object such as enhancing the user's metabolic function by mixed powdered germanium. When the poultice is formed in a wide area, the above-mentioned problems cannot be avoided at present. Therefore, in the case of a configuration in which a highly viscous drug is applied to a base cloth like a conventional cataplasm, the present situation is that only the user (patient) requires self-management to take measures against inflammation. Therefore, for the purpose of use that seeks to enhance the beauty effect, for example, there is a problem in that it is used for a short time in order to enhance its functional effect. Of course, the same applies to the improvement of discomfort in the affected area.

  On the other hand, as is known from Patent Document 2, in the case where an adhesive layer is disposed around the drug layer, the drug layer of the adhesive sheet is pressed against the skin surface with the adhesive layer provided around the drug layer and applied to the skin of the drug. The aim is to improve the penetration of the skin, but no countermeasures against stuffiness due to skin respiration are taken into account.

  As described above, the conventional percutaneous absorption-type external preparation has a problem of lacking consideration for inhibition of skin respiration during its use. One factor is to select a material having a small elongation for the base fabric for applying and supporting the drug. In other words, in the manufacturing process, when a long base fabric is run and the drug is applied to the surface of the fabric, if the base fabric has a large elongation, it is stretched by the applied tension to obtain a good product. I can't. For this reason, a material having a high weaving density is adopted, and in addition, a highly viscous material is used as a drug to be applied, resulting in poor air permeability.

  The present invention has been made in view of such a situation, and can reduce the inhibition of skin respiration due to contact between the skin and the drug application surface, make it less likely to cause stuffiness, and increase the functionality of components contained in the drug. An object of the present invention is to provide an external preparation containing powdered germanium.

In order to achieve the above object, the powdered germanium-containing external preparation of the present invention comprises:
A patch formed by applying a drug mixed with powdered germanium on one side of a base fabric, wherein a coating layer of a drug containing an adhesive with a narrow width is formed around the applied drug layer, A large number of ventilation portions are distributed and formed in the drug layer (first invention).

  In the present invention, the vents formed in the drug layer are preferably formed by interspersed portions where no drug is applied when the drug is applied to the base fabric (second invention).

  In the present invention, the drug layer may be formed of a drug that does not contain at least an adhesive, and a plurality of ventilation portions that penetrate through the base fabric may be distributed from the drug layer (third invention). The vent is preferably formed as a needle hole opening or a cut (fourth invention).

  According to the present invention, when an external preparation (patch) is used, a drug layer containing powdered germanium is applied to the skin surface with a coating layer of a drug containing an adhesive formed around a drug layer containing powdered germanium. In this state, air permeability can be ensured without covering the entire skin surface by a large number of ventilation parts distributed and formed in the drug layer in this state. The effect of transdermal absorption of drug components and the metabolic function of germanium can be exerted more effectively.

  According to the second invention, when the drug layer in the external preparation (patch) is applied, for example, the exposed surface of the base fabric is distributed and formed so as to form a non-adhered portion of the drug on the base fabric surface in a lattice shape. If it is set as the structure to be made, when using this external preparation, since the skin surface to stick is not entirely covered with a chemical | medical agent, it can prevent that skin respiration is inhibited. Moreover, since it is structurally simple, there is no obstacle in production. Further, according to the third invention, according to the second invention, the drug layer occupying the main part does not include an adhesive, and a large number of ventilation portions are formed to penetrate from the drug layer to the base fabric. Similar effects can be obtained. Further, according to the fourth aspect of the present invention, as the ventilation portion from the drug layer to the base fabric, the ventilation portion can be formed by providing a needle hole-like opening or notch in the portion coated with the drug, and the base at the time of manufacture can be formed. Breathability can be secured without considering the stretch of the fabric.

  Next, specific embodiments of the powdered germanium-containing external preparation according to the present invention will be described with reference to the drawings.

  FIG. 1 shows a front view of an embodiment of a powdered germanium-containing external preparation (a poultice) according to the present invention. FIG. 2 shows an AA enlarged sectional view (a) schematically shown in FIG. 1 and an BB enlarged sectional view (b) schematically shown in FIG.

  The external preparation (patch) 10 of this embodiment (hereinafter referred to as “patch preparation 10”) is an entire surface of the base fabric 11 having a required size and having a width appropriately left from the center on one side of the base cloth 11. The drug layer 12 is formed by applying a drug that does not contain an adhesive. Around this drug layer, a drug layer 13 mixed with a pressure-sensitive adhesive (corresponding to a coating layer of a drug containing the pressure-sensitive adhesive of the present invention) is formed with substantially the same thickness as the drug layer 12. A protective release film 15 is laminated and adhered to the surfaces of both the drug layers 12 and 13.

  As the base fabric 11, a nonwoven fabric or a woven fabric having an appropriate thickness is used. It is preferable that the base fabric 11 has good air permeability and is less prone to elongation during chemical coating in the manufacturing process.

  The drug that forms the drug layer 12 is prepared according to the provisions of the Japanese Pharmacopoeia General Rules 23 “Pop Agent” as an external preparation, and an appropriate amount of powdered germanium (mainly a fine powder of an organic germanium compound) is mixed with the base. Is used. The drug layer 12 is preferably adjusted to a low viscosity state. On the other hand, for the drug layer 13, a material obtained by mixing an appropriate amount of a known adhesive with the material in the drug layer 12 is used.

  In the step of applying the drug layer 12 to the surface of the base fabric 11, for example, by applying the non-adhered portions 14 of the drug in a lattice pattern with a drug application roll, the drug layer 12 is applied to the surface of the base fabric 11. The non-adhered portion 14 in the layer 12 becomes a ventilation portion, and a large number of ventilation portions are formed on the skin surface covered with the drug layer 12 in use, thereby obstructing the breathing of the skin blocked by the use of the poultice 10. Will be prevented.

  As the release film 15, a plastic film suitable for protecting the surface by laminating and sticking to the surface of the drug layer 13 including the drug layer 12 and the adhesive is used. The release film 15 is preferably one that can adhere to the surface of the drug layer for the purpose and can be easily peeled off during use. As this peeling film 15, plastic films, such as polyethylene, a polypropylene, nylon, are preferable, for example.

  The cataplasm 10 of the present embodiment configured as described above is exfoliated in the same manner as when it is normally used, for example, when it feels fatigue in the arm, leg or foot, or at the site where muscle pain has developed. The drug layer 12 exposed by peeling off the film 15 is applied, and the drug layer 13 part containing the adhesive at the peripheral edge is adhered and used in close contact with the skin. In this way, the poultice 10 is in contact with the peripheral drug layer 13 so that the entire drug layer 12 of the main body is pressed against the skin surface and the drug component is percutaneously absorbed. When this state is maintained for a long time, the skin where the drug layer 12 is pressed is blocked by the drug layer 12, and a large number of drug non-adhered portions 14 are formed in the drug layer 12. Therefore, these non-drug adhering portions 14 do not hinder breathing on the skin surface as ventilation portions. Therefore, even if the patch 10 is kept attached for a long time within the usable range, it is possible to prevent the adhering portion from being steamed. And the metabolic function of powdered germanium can be made effective.

  Next, FIG. 3 shows an enlarged sectional view (a) schematically showing a part of another embodiment of the patch and a partial plan view (b) thereof.

  This embodiment is applied to the plaster 20 as a patch (external preparation), and the basic configuration is the same as that of the above-described embodiment. This plaster 20 uses a fabric having a high weaving density woven with fine yarns as a base fabric 21 in the same manner as the conventional fabric, and the surface of the base fabric 21 formed in a square is used in the above embodiment. A drug layer 22 coated with a drug mixed with the same powdered germanium as the drug layer 12 described in the above is provided with a required thickness and leaving a portion having a required width at the periphery, and the adhesive layer similar to the above is disposed around the drug layer 22. A drug layer 23 mixed with a drug is formed. In the drug layer 22, a large number of needle-hole-shaped ventilation portions 24 penetrating from the drug layer 22 to the base fabric 21 are formed at appropriate intervals. A release film 25 is adhered and laminated on the surfaces of the drug layers 22 and 23.

  The plaster 20 configured in this manner is used in the same manner as the poultice 10 of the above-described embodiment, and is adhesive formed on the peripheral edge of the base fabric 21 when used on the skin surface of a use site such as an affected part. The drug layer 23 mixed with is adhered and fixed to the skin surface, and the drug layer 22 is pressed against the skin surface. During use, even the base fabric 21 made of a dense woven fabric through which hot air generated from the skin is transmitted to the outside of the base fabric 21 through the ventilation portion 24 provided in the drug layer 22 that does not contain an adhesive can be used without difficulty. Skin respiration is assisted, the occurrence of stuffiness is suppressed, and the onset of inflammation can be prevented even if the plaster 20 is used for a long time.

  Further, a large number of ventilation portions 24 provided in the drug layer 22 in the plaster 20 are stenotically formed using a needle punch or the like in a process after the drug layer 22 is applied to the base fabric 21 in the plaster manufacturing process. Is preferred. Further, in addition to forming the needle hole-shaped ventilation portion 24, a large number of small cuts (not shown) in the longitudinal direction may be formed in an appropriate arrangement with a blade-shaped tool. The function of the above-mentioned ventilation part can be exhibited also by forming such a cut.

  Moreover, as a ventilation part distributed to the chemical | medical agent layer 22 in the plaster 20, the system which intersperses a non-adhered part on the application | coating surface of the chemical | medical agent apply | coated with the chemical | medical agent application roll in the said embodiment can also be employ | adopted. According to this method, the object can be obtained without using a tool such as drilling or cutting.

  As described above, according to the patch of the present embodiment, since both the poultice and the plaster are provided with a function capable of assisting skin respiration during use by attaching a large number of ventilation portions to the drug layer. The effect that it can be used for a time that can sufficiently absorb the medicinal component can be obtained. In particular, if powdered germanium is mixed and used, the metabolic function due to radiation from the mixed powdered germanium (organic germanium) can be rationally utilized, and the body not only through the skin but also through the site of use. The function recovery effect can be expected even more.

The front view of one Embodiment of the powder germanium containing external preparation (patch agent) concerning this invention 1 schematically shows an AA enlarged sectional view (a) in FIG. 1 and FIG. 1 schematically shows an enlarged sectional view BB in FIG. 1 (b). An enlarged cross-sectional view (a) schematically showing a part of another embodiment of the patch and a partial plan view thereof (b)

Explanation of symbols

10 Patch (Patch)
11,21 Base fabric 12,22 Drug layer 13,23 Drug layer mixed with adhesive 14 Non-adhered part (ventilation part)
15, 25 Release film 20 Plaster (patch)
24 Vent

Claims (4)

  A patch formed by applying a drug mixed with powdered germanium on one side of a base fabric, wherein a coating layer of a drug containing an adhesive with a narrow width is formed around the applied drug layer, A powdered germanium-containing external preparation characterized in that a large number of ventilation portions are distributed in the drug layer.   The powder germanium-containing external preparation according to claim 1, wherein the ventilation portions formed in the drug layer are dotted with portions where the drug is not applied when the drug is applied to the base fabric.   2. The powdered germanium-containing external preparation according to claim 1, wherein the drug layer is formed of a drug that does not include at least an adhesive, and a large number of ventilation portions penetrating the base fabric are formed from the drug layer.   The powder germanium-containing external preparation according to claim 3, wherein the ventilation portion is formed by a needle hole-like opening or notch.

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