JP2007097464A - Composition suitable for producing pill - Google Patents
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Abstract
Description
本発明は、植物ステロール20〜55％を含有する丸剤製造に好適な組成物に関する。 The present invention relates to a composition suitable for producing pills containing 20-55% plant sterols.
植物ステロールによるコレステロール低下作用についての研究は、1953年カリフォルニア大学バークレイ校での動物を用いた実験(Proc. Soc. Exptl. Biol. Med. 83, 498-9(1953)), (J. Nutrition 50, 191-201(1953))から始まり、ほぼ同時期に、ヒトでの実験(Circulation 7, 702-6(1953))でも、その低下作用を認めている。 Studies on the cholesterol-lowering effect of plant sterols were conducted in 1953 using experiments with animals at the University of California, Berkeley (Proc. Soc. Exptl. Biol. Med. 83, 498-9 (1953)), (J. Nutrition 50 , 191-201 (1953)), and at almost the same time, in human experiments (Circulation 7, 702-6 (1953)), the reduction effect was recognized.
1974年には、「抗コレステロール剤」(米国特許第3852440号明細書(特許文献１))としての特許が認められ、その有用性は古くから知られている。近年においても、高コレステロール血症患者への有用性(Br. J. Nutr. 86(2), 233-9(2001)(非特許文献１))、吸収阻害機序(Atherosclerosis 160(2), 477-81(2002)(非特許文献２))などの報告がある。 In 1974, a patent as an “anticholesterol agent” (US Pat. No. 3,852,440 (Patent Document 1)) was recognized, and its usefulness has been known for a long time. In recent years, it has been useful for hypercholesterolemia patients (Br. J. Nutr. 86 (2), 233-9 (2001) (Non-patent document 1)), absorption inhibition mechanism (Atherosclerosis 160 (2), 477-81 (2002) (non-patent document 2)).
しかしながら植物ステロールは、水への溶解性は低く、結晶性が非常に高く、油脂へも殆ど溶解しないことから、食品あるいは飲料分野への利用に難点が多い。 However, since plant sterols have low solubility in water, very high crystallinity, and hardly dissolve in fats and oils, there are many difficulties in use in the food or beverage field.
植物ステロールを食品や飲料に利用するための多くの試みがなされてきた。植物ステロールを乳化、分散する方法としては、植物ステロールを含有する水分散型製剤(特開2005-143317号公報(特許文献２))、ビタミンEを利用する方法(J. Am. Oil Chemist. Soc. 27, 414-22(1950(非特許文献３))、特開昭57-206336号公報(特許文献３)、特開平10-179086号公報(特許文献４))、レシチンを利用する方法(特開昭62-126966号公報(特許文献５)、特公平6-59164号公報(特許文献６)、特開2000-300191号公報(特許文献７)、特開2001-171号公報(特許文献８)、特開2004-018591号公報(特許文献９))、マトリックス中に微粉末粒子の形態で存在させる方法(特開2002-345414号公報(特許文献10))、植物ステロール脂肪酸エステルに部分グリセリド、トリグリセリドを含有する植物ステロール含有油脂組成物(特開2002-206100号公報(特許文献11)、特開2002-201484号公報(特許文献12)) などがある。 Many attempts have been made to utilize plant sterols in foods and beverages. As a method for emulsifying and dispersing plant sterols, a water-dispersed preparation containing plant sterols (JP-A-2005-143317 (Patent Document 2)), a method using vitamin E (J. Am. Oil Chemist. Soc 27, 414-22 (1950 (Non-patent Document 3)), JP-A-57-206336 (Patent Document 3), JP-A-10-179086 (Patent Document 4)), a method using lecithin ( Japanese Patent Laid-Open No. 62-126966 (Patent Document 5), Japanese Patent Publication No. 6-59164 (Patent Document 6), Japanese Patent Laid-Open No. 2000-300191 (Patent Document 7), Japanese Patent Laid-Open No. 2001-171 (Patent Document) 8), Japanese Patent Application Laid-Open No. 2004-018591 (Patent Document 9)), a method of existing in the form of fine powder particles in a matrix (Japanese Patent Application Laid-Open No. 2002-345414 (Patent Document 10)), a part of plant sterol fatty acid ester There are plant sterol-containing fats and oils compositions containing glycerides and triglycerides (JP 2002-206100 (Patent Document 11), JP 2002-201484 (Patent Document 12)) and the like.
また、植物ステロールを油脂に溶かす方法としては、ポリグリセリン脂肪酸エステルを含有する油脂製造法(特開2004-091523号公報(特許文献13)、特開2003-226890号公報(特許文献14))、融点の低い植物ステロール脂肪酸エステルを油脂に溶解する方法(特開2005-143317号公報(特許文献15))。また、穀粉類に練りこむ方法としては、麺帯用組成物に配合する方法(特開2003-284516号公報(特許文献16))、揚げ物用組成物に利用する方法(特開2003-284516号公報(特許文献17))、小麦粉存在下で加熱処理し、遊離型植物ステロールを減少させ食感を改善する方法(特開2003-259794号公報(特許文献18))などがある。 Further, as a method for dissolving plant sterols in fats and oils, a method for producing fats and oils containing polyglycerin fatty acid ester (JP 2004-091523 A (Patent Document 13), JP 2003-226890 A (Patent Document 14)), A method of dissolving a plant sterol fatty acid ester having a low melting point in fats and oils (Japanese Patent Laid-Open No. 2005-143317 (Patent Document 15)). Further, as a method of kneading into cereals, a method of blending in a composition for noodle strips (Japanese Patent Laid-Open No. 2003-284516 (Patent Document 16)), a method of using in a fried food composition (Japanese Patent Laid-Open No. 2003-284516) Gazette (Patent Document 17)), and a method of improving the texture by reducing the amount of free plant sterol by heat treatment in the presence of wheat flour (Japanese Patent Laid-Open No. 2003-259794 (Patent Document 18)).
健康食品や嗜好性食品では、錠剤形の食品とする場合が多いが、植物ステロールは独特の蝋状の物性を有し、剤形は植物ステロールを乳化したソフトカプセルが主である。植物ステロールを主成分とした錠剤あるいは丸剤は技術的に難しく、錠剤を作成する場合は打錠機を用い、丸剤を作成する場合は製丸機を用いてそれぞれ作成するが、錠剤あるいは丸剤を得るためには、それぞれの作成に好適な組成物を考案し製造する必要がある。 Health foods and palatability foods are often made into tablet-shaped foods, but plant sterols have a unique waxy physical property, and the dosage form is mainly soft capsules emulsified with plant sterols. Tablets or pills based on plant sterols are technically difficult. When making tablets, use a tableting machine, and when making pills, use a pilling machine. In order to obtain an agent, it is necessary to devise and manufacture a composition suitable for each preparation.
錠剤では、植物ステロールの含有量が20％を越えると、打錠機を使用した場合、スティッキングなどが起き、錠剤形状に問題が生じやすいため、植物ステロール錠剤を作成するためのいくつかの発明の提示がある。植物ステロールを高含有に含む錠剤とする方法としては、炊飯用組成物として、植物ステロールに、有機酸エステルを有するグリセリン脂肪酸エステル、ショ糖脂肪酸エステルを含有し打錠する方法(特開2004-33189号公報(特許文献19))、植物ステロールに天然カルシウム含有物または精製カルシウム素材を含有させ製錠性を改善し、打錠する方法(特開2001-224331号公報(特許文献20))などが知られる。 For tablets, if the content of plant sterol exceeds 20%, when using a tableting machine, sticking and other problems occur, and problems with the tablet shape tend to occur. There is a presentation. As a method for preparing a tablet containing a high content of plant sterol, as a composition for cooking rice, a method for tableting containing a glycerin fatty acid ester having an organic acid ester and a sucrose fatty acid ester in a plant sterol (JP 2004-33189 A) (Patent Document 19)), a method for tableting by improving the tableting property by adding a natural calcium-containing substance or a purified calcium material to a plant sterol (Japanese Patent Laid-Open No. 2001-224331 (Patent Document 20)), etc. known.
ところで丸剤については、打錠品やソフトカプセルにはない、適度に柔らかく、口中で崩壊する性状を有するため、独特の食感や味覚を嗜好できるが、植物ステロールは独特の蝋状性状を有するため、植物ステロールを高濃度に含有させた丸剤を調製することは難しかった。 By the way, pills have moderately soft properties that do not exist in tableted products and soft capsules, and can be tasted with a unique texture and taste, but plant sterols have unique waxy properties. It has been difficult to prepare a pill containing a high concentration of plant sterols.
本発明の課題は、独特の蝋状性状を有する植物ステロールを高含有に含有する丸剤製剤を提供することである。 The object of the present invention is to provide a pill formulation containing a high content of plant sterols having a unique waxy character.
本発明者らは、植物ステロールの製剤化について鋭意検討した結果、植物ステロールを高含有に含有できる丸剤調製に適した組成物を見出した。 As a result of intensive studies on the formulation of plant sterols, the present inventors have found a composition suitable for preparing pills that can contain a high content of plant sterols.
すなわち、本発明の特徴は、植物ステロールの丸剤調製に好適な基材的役目の素材は、基材として知られる蓮根粉、ごぼう粉などの数十種類の素材の中で、米粉であることを見いだしたことにある。 That is, the feature of the present invention is that the material serving as a base material suitable for the preparation of phytosterol pills is rice flour among dozens of materials known as base materials such as lotus root powder and burdock flour. It is in having found.
植物ステロール20〜55％重量に対し、レシチンを5％以上添加し、米粉を基材として、さらに粘着的役目の素材である山芋パウダー、もち米およびトウモロコシ澱粉などを均一に混合したものを作成した。その組成物は製丸機による丸剤製造にとり優れた特性を有することを見出し、本発明を完成するに至った。 5% or more of lecithin is added to 20 to 55% by weight of plant sterol, and rice flour is used as a base material, and then a mixture of yam powder, glutinous rice, corn starch and the like, which are ingredients for sticky roles, is prepared. . The composition was found to have excellent properties for producing pills by a round machine, and the present invention was completed.
すなわち本発明は、
(1)植物ステロール20〜55重量％に対して、米粉及び粘着的役目の素材35〜80重量％からなることを特徴とする丸剤調製用食品組成物、
(2)植物ステロールがブラシカステロール、カンペステロール、スチグマステロール、βシトステロールの内1または2以上からなる(1)記載の植物ステロールを含有する丸剤調製用食品組成物、
(3)粘着的役目の素材が山芋パウダー、ハチミツ、トウモロコシ澱粉、馬鈴薯澱粉、さつまいも澱粉、もち米粉の内1または2種類以上からなる(1)記載の植物ステロールを含有する丸剤調製用食品組成物
に関するものである。
That is, the present invention
(1) A food composition for preparing a pill, comprising 35 to 80% by weight of rice flour and a material having an adhesive role with respect to 20 to 55% by weight of a plant sterol,
(2) Food composition for pill preparation containing plant sterol according to (1), wherein the plant sterol comprises one or more of brush casterol, campesterol, stigmasterol, β-sitosterol,
(3) The food composition for preparing pills containing the plant sterol according to (1), wherein the material having an adhesive role consists of one or more of yam powder, honey, corn starch, potato starch, sweet potato starch, and glutinous rice flour It is about things.
製丸機を用いて丸剤を調製するための食品組成物は、混合しようとする物質を均一に練りこんだ状態であって、適度な柔らかさを有し[状態(1)]、水崩壊試験において崩壊時間が40分から80分に収まるよう[状態(2)]にしたものである。 A food composition for preparing pills using a pill making machine is a state in which the substance to be mixed is uniformly kneaded and has an appropriate softness [state (1)], and water disintegration In the test, [state (2)] was set so that the disintegration time was within 40 to 80 minutes.
本発明において、「練れる」とは、状態(1)および(2)の条件を満たした状態を言い、「練れない」とは、状態(1)および/または状態(2)を満たさない状態を言う。 In the present invention, “kneading” means a state satisfying the conditions of states (1) and (2), and “not kneading” means a state not satisfying states (1) and / or state (2). Say.
表1は、基材的役目の素材５種類150gに対し、植物ステロール(商品名：フィトステロールF タマ生化学（株）製)450g、山芋パウダー(FD)300g、大豆レシチン(ペースト)100gを混合機にて混合し、その製丸性を評価したものである。 Table 1 shows a blender of 450 g of plant sterol (trade name: Phytosterol F Tama Seikagaku Co., Ltd.), 300 g of yam powder (FD), and 100 g of soy lecithin (paste) for 150 g of five types of base material. And the roundness was evaluated.
「練れる」状態を見出すため、基材的役目の素材について種々の素材について検討したが、表１からわかるように米粉においてのみ「練れる」状態を見出し、基材的役目の素材は米粉が好ましいことがわかった。 In order to find the “kneading” state, various materials were examined for the material serving as the base material. As can be seen from Table 1, the state of “kneading” was found only in rice flour. It turned out to be preferable.
表2は、植物ステロールを種々の添加量で添加し、製丸性について調査した。表2記載のパーセンテージで植物ステロールを添加、山芋パウダー(FD)と米粉は2:1の比率で添加し、更に大豆レシチン(ペースト)100gを添加し、合計で1kgとし、混合機にて混合した。この食品組成物の製丸性について評価した。植物ステロールを「練れる」状態となった上限は、55％であった。 In Table 2, phytosterols were added in various addition amounts, and the roundness was investigated. Plant sterols are added in the percentages listed in Table 2, yam powder (FD) and rice flour are added in a ratio of 2: 1, and 100 g of soybean lecithin (paste) is added to make a total of 1 kg, which is mixed in a mixer. . The roundness of the food composition was evaluated. The upper limit at which plant sterols were “kneaded” was 55%.
本発明で用いる植物ステロールは、大豆、菜種などの種子から抽出、精製されたステロールであり、ブラシカステロール、カンペステロール、スチグマステロール、βシトステロールの内1または2以上の混合物である。該植物ステロールは、水への溶解性は低く、結晶性が非常に高く、油脂へも殆ど溶解しないことから、食品あるいは飲料分野への利用に難点が多い。 The plant sterol used in the present invention is a sterol extracted and purified from seeds such as soybeans and rapeseed, and is a mixture of one or more of brassicasterol, campesterol, stigmasterol, and β-sitosterol. Since the plant sterol has low solubility in water, very high crystallinity, and hardly dissolves in fats and oils, there are many difficulties in use in the food or beverage field.
本発明で、レシチンとは大豆及び/又は卵黄由来のものである。
植物ステロールとレシチンの比率は、重量換算で植物ステロール：レシチン＝10:1〜10:5であることが好ましく、より好ましくは、植物ステロール：レシチン10:1.5〜10:2.5である。
In the present invention, lecithin is derived from soybean and / or egg yolk.
The ratio of plant sterol and lecithin is preferably plant sterol: lecithin = 10: 1 to 10: 5 in terms of weight, more preferably plant sterol: lecithin 10: 1.5 to 10: 2.5.
本発明では、丸剤調製のための「練れる」条件を満たすために、米粉を基材とし、更に粘着的役目の素材として、山芋パウダー、ハチミツ、トウモロコシ澱粉、馬鈴薯澱粉、さつまいも澱粉、もち米粉の内の1または2種類以上の素材を用いる。 In the present invention, in order to satisfy the “kneading” condition for preparation of pills, rice flour is used as a base material, and as a material having an adhesive role, yam powder, honey, corn starch, potato starch, sweet potato starch, glutinous rice flour Use one or more of the materials.
米粉と粘着的役目の素材の比率は、重量換算で米粉：粘着的役目の素材＝2:1〜2:14であることが好ましく、より好ましくは、米粉：粘着的役目の素材＝2:2〜2:6である。 The ratio of the rice flour to the adhesive role material is preferably, in terms of weight, rice flour: adhesive role material = 2: 1 to 2:14, more preferably rice flour: adhesive role material = 2: 2. ~ 2: 6.
本発明の丸剤製造に適した植物ステロール含有食品組成物は以下に述べる方法で製造できる。例えば、植物ステロール450g、レシチン70g、米粉150g、山芋パウダー300g、寒梅粉(もち米粉とトウモロコシ澱粉のブレンド品)30gを量りとり、混合した後、練り機で均質化をはかる。かくして得られる植物ステロールを含有する食品組成物は製丸機による丸剤製造に好適な組成物である。 The plant sterol-containing food composition suitable for producing the pill of the present invention can be produced by the method described below. For example, 450 g of plant sterol, 70 g of lecithin, 150 g of rice flour, 300 g of yam powder, and 30 g of cold plum powder (blended product of glutinous rice flour and corn starch) are weighed and mixed, and then homogenized with a kneader. The food composition containing the plant sterol thus obtained is a composition suitable for producing pills by a round machine.
この植物ステロールを含有する食品組成物は、フレーバー、色素や甘味料を加えて、嗜好性を向上させることも可能であり、食品の機能性向上を期待して、ビタミンなどを添加することも可能である。また、植物ステロールがコレステロール低下作用を有することから、その生理的機能を期待した使用方法も採用できる。 The food composition containing this plant sterol can be added with flavors, pigments and sweeteners to improve palatability, and vitamins can be added to improve food functionality. It is. Moreover, since plant sterol has a cholesterol-lowering action, the usage method which anticipated the physiological function is also employable.
本発明によって、コレステロール低下作用を有する植物ステロールを高含有に含有する丸剤の調製が可能となる。 According to the present invention, it is possible to prepare a pill containing a high content of a plant sterol having a cholesterol lowering action.
以下に本発明の実施例を挙げて、より詳細に説明するが、本発明はそれらによって限定されるものではない。 Examples of the present invention will be described below in more detail, but the present invention is not limited thereto.
[実施例１]
植物ステロール(商品名：フィトステロールF タマ生化学（株）製)450g、山芋パウダー(FD)300g、米粉150g、大豆レシチン(ペースト)100gを混合機にて混合した。この食品組成物を製丸機にかけ、丸剤を得た。水崩壊試験で崩壊時間は40分、水分含量は7％であった。
[Example 1]
450 g of plant sterol (trade name: Phytosterol F manufactured by Tama Biochemical Co., Ltd.), 300 g of yam powder (FD), 150 g of rice flour, and 100 g of soybean lecithin (paste) were mixed in a mixer. This food composition was put on a round machine to obtain a pill. In the water disintegration test, the disintegration time was 40 minutes and the water content was 7%.
[実施例２]
植物ステロール(商品名：フィトステロールF タマ生化学（株）製)450g、山芋パウダー(FD)300g、米粉150g、寒梅粉30g、大豆レシチン(ペースト)70gを混合機にて混合した。この食品組成物を製丸機にかけ、丸剤を得た。水崩壊試験で崩壊時間は68分、水分含量は7％で、安定性の高い丸剤を得た。
[Example 2]
450 g of plant sterol (trade name: Phytosterol F manufactured by Tama Biochemical Co., Ltd.), 300 g of yam powder (FD), 150 g of rice flour, 30 g of cold plum powder, and 70 g of soybean lecithin (paste) were mixed in a mixer. This food composition was put on a round machine to obtain a pill. In the water disintegration test, the disintegration time was 68 minutes, the water content was 7%, and a highly stable pill was obtained.
[実施例３]
植物ステロール(商品名：フィトステロールF タマ生化学（株）製)、450g、山芋パウダー(FD)、250g、米粉、150g、ビタミンEパウダー(商品名：D‐α‐トコフェロール・パウダー50 エーザイ・フード・ケミカル社製)、100g、大豆レシチン(ペースト)50gを混合機にて混合した。この食品組成物を製丸機にかけ、水崩壊試験で崩壊時間は80分、水分含量は7％の安定性の高い丸剤を得た。
[Example 3]
Plant sterol (trade name: Phytosterol F manufactured by Tama Biochemical Co., Ltd.), 450 g, Japanese yam powder (FD), 250 g, rice flour, 150 g, vitamin E powder (trade name: D-α-tocopherol powder 50 Eisai Food Chemical Co., Ltd.), 100 g, and soybean lecithin (paste) 50 g were mixed in a mixer. This food composition was subjected to a round machine, and a highly stable pill having a disintegration time of 80 minutes and a water content of 7% was obtained in a water disintegration test.
[実施例４]
植物ステロール(商品名：フィトステロールF タマ生化学（株）製)、450g、山芋パウダー(FD)、320g、米粉、100g、ビタミンEオイル (商品名：E‐MIX‐α1000 エーザイ・フード・ケミカル社製)、80g、大豆レシチン(ペースト)50gを混合機にて混合した。この食品組成物を製丸機にかけ、水崩壊試験で崩壊時間は75分、水分含量は8％の安定性の高い丸剤を得た。
[Example 4]
Plant sterol (trade name: Phytosterol F manufactured by Tama Biochemical Co., Ltd.), 450 g, Japanese yam powder (FD), 320 g, rice flour, 100 g, vitamin E oil (trade name: E-MIX-α1000, manufactured by Eisai Food Chemical Co., Ltd.) ), 80 g, and soybean lecithin (paste) 50 g were mixed in a mixer. This food composition was subjected to a round machine, and a highly stable pill having a disintegration time of 75 minutes and a water content of 8% was obtained in a water disintegration test.
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| JP2005291036A JP2007097464A (en) | 2005-10-04 | 2005-10-04 | Composition suitable for producing pill |
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| JP2005291036A JP2007097464A (en) | 2005-10-04 | 2005-10-04 | Composition suitable for producing pill |
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| JP2007097464A true JP2007097464A (en) | 2007-04-19 |
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| JP2005291036A Pending JP2007097464A (en) | 2005-10-04 | 2005-10-04 | Composition suitable for producing pill |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010229095A (en) * | 2009-03-27 | 2010-10-14 | Kobayashi Pharmaceutical Co Ltd | Solid composition for oral administration |
| CN103766745A (en) * | 2014-02-25 | 2014-05-07 | 江西百神药业股份有限公司 | Spleen strengthening eight-treasure pudding and preparation method thereof |
| CN109529056A (en) * | 2018-12-29 | 2019-03-29 | 国药集团中联药业有限公司 | A kind of medicine pill clinical test placebo and preparation method thereof |
| KR20190110229A (en) * | 2018-03-20 | 2019-09-30 | 천지인초 주식회사 | A composition containing natural materials extract as an active ingredient for treatment of menopause symptoms, and manufacturing method of the same |
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| JPH08332054A (en) * | 1995-06-07 | 1996-12-17 | Nissei Kosan Kk | Food for slender figure |
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| WO2004105770A1 (en) * | 2003-05-31 | 2004-12-09 | Forbes Medi-Tech Inc. | Composition comprising one or more phytosterols and/or phytostanols and glucomannan and uses of the composition in treating lipid disorders in individuals with and without type ii diabetes |
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| JPH08332054A (en) * | 1995-06-07 | 1996-12-17 | Nissei Kosan Kk | Food for slender figure |
| JP2004525856A (en) * | 1999-11-04 | 2004-08-26 | モンサント テクノロジー エルエルシー | Cholesterol-lowering sterol compositions, methods of preparation and use |
| JP2004049102A (en) * | 2002-07-19 | 2004-02-19 | Takashi Ito | Health food and method for producing the same |
| WO2004105770A1 (en) * | 2003-05-31 | 2004-12-09 | Forbes Medi-Tech Inc. | Composition comprising one or more phytosterols and/or phytostanols and glucomannan and uses of the composition in treating lipid disorders in individuals with and without type ii diabetes |
| JP2006325571A (en) * | 2005-05-26 | 2006-12-07 | Kodama Shokuhin Kk | Phytosterols or/and phytostanols-containing edible powders and method for producing the same |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010229095A (en) * | 2009-03-27 | 2010-10-14 | Kobayashi Pharmaceutical Co Ltd | Solid composition for oral administration |
| CN103766745A (en) * | 2014-02-25 | 2014-05-07 | 江西百神药业股份有限公司 | Spleen strengthening eight-treasure pudding and preparation method thereof |
| KR20190110229A (en) * | 2018-03-20 | 2019-09-30 | 천지인초 주식회사 | A composition containing natural materials extract as an active ingredient for treatment of menopause symptoms, and manufacturing method of the same |
| KR102105540B1 (en) | 2018-03-20 | 2020-04-28 | 천지인초 주식회사 | A composition containing natural materials extract as an active ingredient for treatment of menopause symptoms, and manufacturing method of the same |
| CN109529056A (en) * | 2018-12-29 | 2019-03-29 | 国药集团中联药业有限公司 | A kind of medicine pill clinical test placebo and preparation method thereof |
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