JP2005522293A5

JP2005522293A5 -

Info

Publication number: JP2005522293A5
Application number: JP2003584690A
Authority: JP
Filing date: 2003-04-04
Publication date: 2006-05-25
Anticipated expiration: 2023-04-04

Claims

A fiber optic probe having a proximal end and a distal end;
A delivery optical fiber in a probe connected to the light source at the proximal end and having a first filter at the distal end;
A collection optical fiber in a probe for collecting Raman scattered light from tissue having a second filter at the proximal end and connected to a detector at the proximal end; and a delivery waveguide and collection fiber connected to the delivery fiber A tissue measurement probe comprising an optical system at a distal end of the probe including a collection waveguide connected to the probe.

The probe of claim 1, wherein the delivery waveguide comprises a rod and the collection waveguide comprises a cylindrical tube that is concentric around the rod.

The probe of claim 1, wherein the lens comprises a ball lens optically connected to the delivery fiber and the collection fiber.

The probe of claim 1 further comprising a sleeve that optically isolates the delivery waveguide from the collection waveguide.

A first plurality of collection fibers disposed concentrically around the delivery fiber at a first radius, and a second plurality disposed concentrically around the delivery fiber at a second radius greater than the first radius The probe of claim 1, further comprising a plurality of collection fibers.

The probe of claim 1 further comprising a controller that gates a collection time that is less than 2 seconds.

The probe according to claim 1, wherein the optical system has a length of less than 10 mm.

The probe according to claim 1, wherein the optical system has a length of less than 4 mm.

The probe according to claim 1, wherein the light source has a wavelength longer than 750 nm.

The probe of claim 1, wherein the optical system delivers and collects light in the radial direction.

The probe according to claim 1, wherein the probe measures spectral characteristics of cardiac tissue.

The probe of claim 1, wherein the distal end has a diameter of 2 mm or less.

The probe of claim 1, further comprising a light source optically connected to the proximal end of the delivery optical fiber.

The probe according to claim 1, wherein the optical system includes a refractive optical element.

The probe according to claim 1, wherein the optical system comprises a reflective optical element.

The probe according to claim 1, wherein the optical system comprises a part of a ball lens.

The probe according to claim 1, further comprising an endoscope having a channel into which the probe is inserted.

The probe according to claim 1, wherein the optical system comprises a spectroscopic diagnostic meter with a lens system.

A fiber optic probe having a proximal end, a distal end;
A delivery optical fiber in a probe having a first filter at the distal end and connected at the proximal end to a light source for delivering radiation to the distal end;
A collection optical fiber in a probe for collecting Raman scattered radiation from tissue having a second filter at the distal end connected to a detector system at the proximal end; and a delivery waveguide and collection connected to the delivery optical fiber A spectroscopic diagnostic system for tissue measurement comprising an optical lens system at the distal end of a probe including a collection waveguide connected to an optical fiber and a lens system.

Delivery waveguides becomes and collection waveguides include a first cylindrical tube comprises a second cylindrical tube are concentric around the first cylindrical tube, according to claim 19 Spectroscopic diagnostic system.

20. A spectroscopic diagnostic system according to claim 19 , wherein the lens system comprises an elliptical axicon optically connected to the delivery optical fiber and the collection optical fiber.

The spectroscopic diagnostic system of claim 19 , wherein the spectroscopic diagnostic system generates an ambient image.

The probe of claim 1, wherein the probe comprises a catheter.

A fiber optic probe having a proximal end and a distal end;
At least one delivery optical fiber in a probe connected to the proximal end of the light source and having a first filter at the distal end;
At least one collection optical fiber in a probe for collecting Raman scattered radiation from tissue having a second filter at the distal end and connected to the proximal end of the detector; and a delivery waveguide connected to the delivery optical fiber A spectroscopic catheter system for measurement comprising a tube, a collection waveguide connected to a collection optical fiber, and an optical system at the distal end of the probe including one of reflective and refractive optical elements.

25. The spectroscopic catheter system of claim 24 , further comprising an inflatable balloon disposed about the fiber optic probe.

26. The spectroscopic catheter system of claim 25 , further comprising a channel for inflating the balloon.

At least one delivery optical fiber in a probe having a proximal end, a distal end, a proximal end connected to a light source and having a first filter at the distal end, and a proximal end connected to a detector and distal Providing a fiber optic probe having at least one collection optical fiber in a probe that collects Raman scattered radiation from a sample having a second filter at the end; and a delivery waveguide connected to the delivery optical fiber and a collection optical fiber A method for measuring a sample comprising collecting light from the sample using optics at the distal end of the probe including a connected collection waveguide.

28. The method of claim 27 , further comprising inflating a balloon disposed about the fiber optic probe.

30. The method of claim 28 , further comprising inflating a balloon through a channel in the probe.

28. The method of claim 27 , further comprising providing a delivery waveguide comprising a rod and providing a collection waveguide comprising a cylindrical tube that is concentric around the rod. Method.

Further comprising: providing a first cylindrical tube; and providing a collection waveguide comprising a second cylindrical tube that is concentric around the first cylindrical tube. Item 28. The method according to Item 27 .

28. The method of claim 27 , further comprising providing an optical element comprising an elliptical axicon optically connected to the delivery optical fiber and the collection optical fiber.

28. The method of claim 27 , further comprising providing a sleeve that optically isolates the delivery waveguide from the collection waveguide.

A first plurality of collection fibers disposed concentrically around the delivery fiber at a first radius, and a second plurality disposed concentrically around the delivery fiber at a second radius greater than the first radius 28. The method of claim 27 , further comprising providing a plurality of collection fibers.

28. The method of claim 27 , further comprising generating an ambient image.

28. The method of claim 27 , further comprising propagating light using a ball lens optically connected to the delivery optical fiber and the collection optical fiber.

28. The method of claim 27 , further comprising controlling a collection time that is less than 2 seconds.

28. The method of claim 27 , further comprising rotating the distal end of the probe to direct light radially in a plurality of directions.

28. The method of claim 27 , further comprising a method of processing Raman data from the tissue.

40. The method of claim 39 , further comprising processing the data to diagnose cancerous tissue.

28. The method of claim 27 , further comprising performing real-time in vivo analysis of the spectral data.

28. The method of claim 27 , further comprising detecting an arterial fibrous capsule having a thickness of less than 65 microns.

28. The method of claim 27 , further comprising detecting a lipid pool, inflammatory cells, foam cells or thrombus.

28. The method of claim 27 , further comprising detecting using a probe having a diameter of 1.5 mm or less.

28. The method of claim 27 , further comprising inserting the probe into a body cavity or artery and rotating the probe to scan the body cavity or artery as the probe is removed.

28. The method of claim 27 , further comprising diagnosing breast tissue.

28. The method of claim 27 , further comprising inserting the probe through a needle.

28. The method of claim 27 , further comprising providing a half ball lens on a mirror at the distal end of the probe.

A delivery path connected to the light source at the proximal end and having a first filter;
A collection path for collecting Raman scattered light from tissue having a second filter connected at a proximal end to a detector system including a distribution element and a detector, and processing Raman spectral data from the detector system A microscope system for tissue measurement, comprising a data processor.

50. The system of claim 49 , further comprising a charge coupled device sensor.

50. The system of claim 49 , wherein the data processor determines the presence of a plurality of tissue components.

50. The system of claim 49 further comprising a CCD camera.

50. The system of claim 49 , further comprising a controller that controls the laser light source, shutter, and detector.

50. The system of claim 49 , further comprising detecting a Raman signal in the range of 400-2000 cm- ¹ .