JP2005162616A - Medical sheet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical sheet sustaining moderate pressure-sensitive adhesion to the skin and exudation of an active ingredient. <P>SOLUTION: A dissolved substance prepared by mixing and dissolving 6-25 wt.% of a thermoplastic elastomer, 0-28 wt.% of a pressure-sensitive adhesion imparting agent, 60-90 wt.% of a liquid ingredient and 0.01-35 wt.% of a medicinal effect additive is solidified and formed into an elastic body 2 having pressure-sensitive adhesion. The resultant elastic body 2 is then supported on a support 3 and covered with release paper 4. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a sheet-like or tape-like medical sheet for the purpose of being attached to the skin, and more particularly to a medical sheet suitable for administering a cosmetic medicinal component contained in an adhesive to the skin.

  As a type of medical sheet for transdermal administration of medicinal ingredients applied to the skin, external adhesive patch containing blood circulation promoting component, moisturizing component, anti-wrinkle component, whitening component, skin disease improving component, vitamin component etc. in adhesive It has been known. Such a medical sheet to be applied to the skin has an adhesive composition that has an appropriate adhesive force, has little skin irritation, and does not cause cohesive failure or interfacial failure at the time of peeling. There is a demand for a structure in which the contained medicinal liquid component is appropriately exuded.

In order to satisfy the above requirements, workability and dissolution of bioactive substances are dissolved in 100 parts by weight of a triblock copolymer containing 25 to 40% by weight of vinyl aromatic hydrocarbon in (hydrogenated) conjugated diene as a base polymer. Skin patch containing 50 to 300 parts by weight of a plasticizing component for imparting skin property and skin adhesiveness and 0.001 to 100 parts by weight of a life-active component (medicinal liquid component) has been proposed (patent) Reference 1).
JP 2002-284676 A (pages 2 to 3)

  Although the above prior art can be easily manufactured industrially, it is difficult to obtain an appropriate adhesive strength to the skin and adhesiveness that does not cause cohesive failure or interfacial failure when peeled from the skin. It is difficult to gradually exude the liquid component containing the component and maintain the medicinal properties.

  An object of the present invention is to provide a medical sheet that achieves both moderate adhesiveness to the skin and continuous exudation of a liquid component containing a medicinal component.

  In order to achieve the above object, the medical sheet according to the present invention has a total weight of 6 to 25% by weight of thermoplastic elastomer, 0 to 28% by weight of tackifier, 60 to 90% by weight of liquid component, The elastic body which has adhesiveness is formed with the mixture which an additive contains in the ratio of 0.01 to 35 weight%, It is characterized by the above-mentioned.

  With the above structure, the liquid component and the tackifier that are compatible with the thermoplastic elastomer are formed into an elastic body having an appropriate adhesiveness to the skin by plasticizing the thermoplastic elastomer. The adhesiveness to the skin that does not occur is obtained, and at the same time, a large amount of liquid component including the medicinal component oozes out gradually, so that the effect of administering the medicinal component to the skin is maintained.

  In the above configuration, the thermoplastic elastomer is one or a selected from a styrene isoprene styrene block copolymer, a styrene butadiene styrene block copolymer, a styrene ethylene styrene block copolymer, and a styrene butylene styrene block copolymer. A mixture of at least two of the above is preferred.

  Tackifiers are rosin, hydrogenated rosin, rosin ester, terpene resin, modified terpene resin, hydrogenated terpene resin, terpene phenol resin, petroleum resin, coumarone / indene resin, phenol resin, xylene resin, alicyclic saturated At least one selected from hydrocarbon resins is preferred.

  Further, the liquid component belongs to oils and fats, liquid waxes, liquid hydrocarbons, higher fatty acids, fatty acids, nonionic surfactants, liquid resins, and oily vitamins that are liquid at least at 0 to 40 ° C. More than one component can be suitably used.

  Further, the formed elastic body having adhesiveness is stably held by being supported by the support. The amount of the medicinal component per unit area can be adjusted by adjusting the thickness of the elastic body supported on the support.

  Further, by covering the elastic body with release paper, the adhesive surface is exposed when the release paper is peeled off, so that it can be attached to the skin.

  Moreover, it can affix on a treatment site | part without excess and deficiency by forming in the form cut out to the shape dimension corresponding to an adhesion site | part.

  According to the medical tape according to the present invention, a liquid component containing a medicinal component gradually oozes out while at the same time obtaining an appropriate adhesive force to the skin, so that the medicinal component can penetrate into the skin, in particular a moisturizing component, It is effective as a cosmetic medical sheet for transdermal administration such as anti-wrinkle component and whitening component.

  In the present embodiment, a required medicinal component is contained in an adhesive, and the liquid component containing the medicinal component gradually exudes toward the skin while having a preferable sticking property to the skin. The example comprised to the medical sheet | seat is shown. By changing the kind and amount of the medicinal component, it can be constituted into a medical medical sheet for transdermal administration of the medicinal component.

  The pressure-sensitive adhesive is formed by adding a tackifier and a liquid component to a thermoplastic elastomer. As thermoplastic elastomer, styrene isoprene styrene block copolymer (SIS) considering compatibility with liquid components, operability and handling at the time of mixing by solvent or heating, availability, unit price, etc. Adopting one selected from styrene butadiene styrene block copolymer (SBS), styrene ethylene styrene block copolymer, styrene butylene styrene block copolymer or a mixture of at least two selected However, in view of economy, styrene isoprene styrene block copolymer (SIS) is preferable.

  In the ABA type block copolymer as described above, AB has different solubility parameters, and the A phase is called an end block phase and contributes to the structure retention. The B phase is called a mid-block phase, has rubber-like properties, and exhibits adhesiveness when plasticized. The cross-linked structure of the end block phase is not fixed, is reversible, is plasticized by solvent or heating, and is fixed by evaporation or cooling of the solvent.

  Further, as the tackifier, as specific components, rosin, hydrogenated rosin, rosin ester, terpene resin, modified terpene resin, hydrogenated terpene resin, terpene phenol resin, petroleum resin, coumarone / indene resin, phenol resin, A xylene resin, an alicyclic saturated hydrocarbon resin, or the like, which is selected and used.

  The liquid component is selected to be compatible with the thermoplastic elastomer. Specific examples thereof include silicone oils such as methylpolysiloxane, methylphenylpolysiloxane, and dodecamethylpolysiloxane, avocado oil, and almond oil. , Olive oil, cacao butter, beef tallow, sesame oil, wheat germ oil, safflower oil, turtle oil, persimmon oil, persic oil, castor oil, grape oil, macadamia nut oil, mink oil, egg yolk oil, safflower oil, molasses, palm oil, rose pip Oils and fats, liquid waxes such as orange luffy oil and jojoba oil, liquid hydrocarbons such as liquid paraffin, liquid petrolatum, suclawan and squalene, higher fatty acids such as lauric acid, myristic acid and oleic acid, hexyldecanol, octyl High-grade alcohol such as dodecanol and isostearic alcohol Fatty acid esters such as ethyl, linoleate, isopyrupyl myristate, hexyl laurate, octyldodecyl myristate, decyl oleate, octyldodecyl oleate, hexyldecyl dimethyloctanoate, polyoxyethylene nonylphenyl ether, polyexethylene Nonionic interfaces such as octylphenyl ether, sorbitan fatty acid ester, fatty acid glycerin ester, propylene glycol fatty acid ester, fatty acid polyethylene glycol, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester Activators, liquid resins such as polybutene, polyisoprene, polyacrylic acid, polymethacrylic acid, retinol, retino palmitate Le, tocopherols, can indicate the oily vitamins acetate tocopherol and the like. Of these, those which are liquid at 0 to 40 ° C. are preferred, and those which are liquid at 25 to 30 ° C. are more preferred. These liquid components are used by mixing one or more kinds as required.

  In the present invention, the tackifier and the liquid component plasticize the thermoplastic elastomer, give good adhesiveness when the medical sheet is affixed to the skin, and cohesive failure occurs when the medical sheet is peeled from the skin. It maintains the strength without causing interface breakage, and further effectively acts and maintains the medicinal component added as an additive on the skin, thereby effectively improving the anchoring property to the support.

  In this embodiment, since it forms in a cosmetic medical sheet, vitamins, a moisturizer, a whitening agent, an astringent, etc. are added to the said component as an additive according to the objective of makeup.

  In addition, when forming for medical use, anti-inflammatory analgesics, tranquilizers, steroids, antihypertensives, analgesics, antihistamines, antitussives, antibacterial agents, antifungal agents, antiepileptics, antiemetics, antiacne agents Etc. are added depending on the medical purpose.

  Add antioxidants, preservatives, UV absorbers, solubilizers, fillers, emulsifiers, pH adjusters, absorption promoters, water absorption agents, etc. for the purpose of stability, safety, and promotion of efficacy. You can also.

  The above-mentioned tackifier, liquid component, tackifier, and additive are in a total weight ratio of 6 to 25% by weight for thermoplastic elastomer, 60 to 90% by weight for liquid component, and 0 to 28 for tackifier. % By weight and additives are formed into a mixture mixed within the range of 0.01 to 35% by weight. This mixture is melted by heating to form a melt, and as shown in FIG. 1, it is applied to a predetermined thickness on a release paper 4 using a doctor roll, reverse roll, etc., and cooled to give a sticky elasticity. A cosmetic medical sheet 1 in which the body 2 is supported on the release paper 4 can be obtained. By sticking the support 3 to the surface of the elastic body 2 having adhesiveness of the medical sheet 1, when the release sheet 4 is peeled off when used, it is attached to the required skin by the adhesiveness of the elastic body 2. Can do.

  The support 3 does not absorb liquid components or additives and does not release the support 3 out of the support 3 and is selected from stretchable or non-stretchable depending on the place of application. It is desirable that the shape retains the shape as 1, and is a material that deforms along the curved surface of the skin. Specifically, films such as polyurethane, polyester, polyethylene terephthalate, polypropylene, polyvinyl chloride, nylon, rayon, non-woven fabric, net, cloth, paper, and the like can be used. These may be a single layer or two or more selected laminates. Among these, films such as polyurethane, polyester, polyethylene terephthalate, polypropylene, polyvinyl chloride, nylon and rayon are preferable, and the thickness is preferably 100 μm or less.

  When the manufacturing method for dissolving the mixture by heating as described above includes a composition that deteriorates or deteriorates by heating, a manufacturing method for dissolving the mixture with a solvent as shown below should be adopted. Can do.

  A mixture of thermoplastic elastomer, tackifier, liquid components, and additives mixed according to the required weight percent is dissolved in an organic solvent to form a melt, and this melt is peeled off using a doctor roll, reverse roll, etc. A medical sheet 1 in which an adhesive elastic body 2 is supported on a release paper 4 can be obtained by applying a predetermined thickness on paper 4 and heating and blowing air as necessary to evaporate and dry the solvent. it can. Also in this manufacturing method, as described above, the melt is applied to the release paper 4 to a predetermined thickness, and the solvent is evaporated to dryness from the melt to form the adhesive elastic body 2 on the release paper 4. The medical sheet 1 can be similarly formed by placing the support 3 on the elastic body 2 and transferring it.

  Examples of the organic solvent include toluene, ethyl acetate, butyl acetate, hexane, benzene, methyl ethyl ketone, methanol, ethanol, propanol, butanol, and acetonitrile. Thermoplastic elastomers used, tackifiers, liquid components, additives It is selected according to.

  When adopting a production method in which the mixture is dissolved with an organic solvent as described above, if the support 3 has a rough surface like a non-woven fabric and is rough and porous, the dissolved product may fall out. Even if it does not fall out, the dissolved material penetrates into the inside, so that the dissolved material is consumed excessively. Therefore, it is preferable to employ the above-described production method by transfer. Further, when the support 3 is formed of a net, it is a matter of course that the manufacturing method by transfer described above is preferable.

  Further, the formed adhesive elastic body 2 is superior in anchoring property to a support 3 such as a polyurethane nonwoven fabric or PET elastomer nonwoven fabric, which is generally poor in anchoring property of the adhesive, and thus manufactured by transfer as described above. Also by the method, the support 3 can be securely bonded. Therefore, the medical sheet 1 in which the adhesive elastic body 2 is bonded to the support 3 such as a polyurethane nonwoven fabric or a PET elastomer nonwoven fabric having excellent flexibility and flexibility is adhered to a bending portion such as an elbow or a knee. In addition, there is no possibility of delamination even by bending, and there is no risk of adhesive residue on the skin accompanying delamination.

  When the medical sheet 1 manufactured in a predetermined manufacturing size is used for cosmetics, the shape corresponding to the part to be attached, for example, as shown in FIG. It is an easy-to-use form to have a shape punched into a curved shape of the required length. In addition, it can be formed into a form that is half-cut into a required shape at a portion excluding the release paper 4, and a form in which a plurality of cosmetic medical sheets punched in the same shape are arranged on one release paper 4, When a plurality of cosmetic medical sheets punched into a plurality of shapes corresponding to each part to be stuck on one sheet of release paper 4 are arranged and used, when any cosmetic medical sheet is peeled off from release paper 4 It can be applied to the required part of the skin as it is.

  In the case of a cosmetic medical sheet, a form that is punched out or half-cut into a shape corresponding to the sticking site as described above is preferable, but in the case of a medical or general-purpose medical sheet, an arbitrary size Can be cut into squares or tapes. In the case of a tape-like medical sheet, when a sheet having a required length is wound into a plurality of required widths, it can be formed into a wound tape.

  Hereinafter, for the medical sheets of Examples 1 to 7 and Comparative Examples 1 to 3 manufactured by blending thermoplastic elastomers, tackifiers, and oily components at various blending ratios, oil oozes and pain during peeling The results of verifying the adhesive strength are shown in Table 1. Specifically, SIS (Quintac 3570-C, manufactured by Nippon Zeon Co., Ltd.), aliphatic saturated hydrocarbons, and liquid paraffin were dissolved in a solvent, and uniform on a 25 μm thick polyethylene terephthalate transparent sheet at a coating amount of 100 g / m 2. It applied so that it might become thickness, and the test piece was obtained.

  In the oil oozing test, a test piece having a width of 50 mm and a length of 50 mm was attached to PPC paper, peeled after 5 hours, and the oil oozing condition was evaluated from the following viewpoints.

  ○: The PPC paper is contaminated with a size equal to or larger than the size of the test piece.

Δ: The PPC paper is contaminated at a size equal to or less than the size of the test piece, and the contaminated part cannot be recognized unless the eyes are looked closely.

  X: No contamination.

  The test for pain at the time of peeling was conducted by extracting 5 subjects from volunteers, attaching a test piece 50 mm wide x 50 mm long to the inner side of the upper arm, peeling after 2 hours, and the degree of pain at the time of peeling. Was evaluated by a five-step evaluation, with 1 point indicating almost no pain and 5 points when unbearable pain occurred. Evaluation is an average of 5 persons. Moreover, the presence or absence of cohesive failure and interface failure was visually observed during peeling.

  The adhesive strength test was performed by attaching a strip-shaped test piece cut to a width of 5 mm and a length of 300 mm to a bakelite plate, reciprocating the roller once with a load of 1000 g to bring the test piece into close contact with the bakelite plate, and then 300 mm in the direction of 180 degrees. The film was peeled at a rate of / min and measured with a tensile tester (Autograph AGS-500NG, manufactured by Shimadzu Corporation) (JIS Z 0237). Moreover, the presence or absence of cohesive failure and interface failure was visually observed during peeling.

  As described above, according to the present invention, it can be formed into a medical sheet having moderate adhesiveness to the skin and in which the liquid medicinal component continues to exude, and particularly contains a large amount of liquid component in the adhesive sheet. Therefore, it is suitable as a medical sheet for cosmetics.

Sectional drawing which shows the structure of the medical sheet which concerns on embodiment. The top view which shows the example formed in the eye pack sheet.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical sheet 2 Elastic body 3 Support body 4 Release paper

Claims (8)

The total weight includes 6 to 25% by weight of thermoplastic elastomer, 0 to 28% by weight of tackifier, 60 to 90% by weight of liquid component, and 0.01 to 35% by weight of medicinal additives. A medical sheet comprising an adhesive elastic body formed by a mixture. The thermoplastic elastomer is one selected from styrene isoprene styrene block copolymer, styrene butadiene styrene block copolymer, styrene ethylene styrene block copolymer, styrene butylene styrene block copolymer, or at least two selected. The medical sheet according to claim 1, which is a mixture of seeds. Tackifiers are rosin, hydrogenated rosin, rosin ester, terpene resin, modified terpene resin, hydrogenated terpene resin, terpene phenol resin, petroleum resin, coumarone / indene resin, phenol resin, xylene resin, alicyclic saturated hydrocarbon The medical sheet according to claim 1, wherein the medical sheet is at least one selected from resins. The liquid component is one or more of oils and fats, liquid waxes, liquid hydrocarbons, higher fatty acids, fatty acids, nonionic surfactants, liquid resins, oily vitamins that are liquid at least at 0 to 40 ° C. The medical sheet according to claim 1, which is a component of The medical sheet according to claim 1, wherein the elastic body is supported by a support. The medical sheet of Claim 1 or 4 which adjusts the thickness of the elastic body supported on the support body. The medical sheet according to any one of claims 1, 4, and 5, wherein the elastic body is covered with a release paper. The medical sheet as described in any one of Claims 1, 4, 5, and 6 cut out to the shape dimension corresponding to a sticking site | part.

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