JP2004354344A - Light source device and biomolecule analysis apparatus using the light source device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a light source device and a biomolecule analysis apparatus using the light source for performing two-dimensional scanning and three-dimensional scanning by a simple mechanism. <P>SOLUTION: The apparatus comprises a plurality of light sources (114) which are arranged in a two-dimensional manner on a plane and a plurality of optical members (122, 132) which are arranged corresponding to the plurality of light sources, shape light emitted from each of the plurality of light sources into approximately parallel light flux, and deflect the light flux to a predetermined direction. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a planar light source device in which optical elements are two-dimensionally arranged on a plane, and a biomolecule analyzer to which the light source device is applied.
[0002]
[Prior art]
The confocal scanning optical microscope is described in Non-Patent Document 1, for example. In addition, Non-Patent Literature 2 and the like mainly provide explanations for biological samples. Regarding the fluorescence correlation spectroscopy, there is a commentary in, for example, Non-Patent Document 3.
[0003]
In the 1990s, research on single molecule detection and imaging using fluorescence has been rapidly increasing. For example, Non-Patent Document 4 and fluorescence correlation spectroscopy (FCS) are examples of a method for detecting a single molecule. In fluorescence correlation spectroscopy, fluorescently labeled proteins and carrier particles are suspended in a solution in the field of view of a confocal laser microscope, and the fluctuations in fluorescence intensity based on Brownian motion of these particles are analyzed to determine the autocorrelation function. Then, the number and size of the target fine particles are estimated. This technique is discussed in Non-Patent Document 5, for example.
[0004]
Several patent applications have been filed for the above technology.
For example, in Patent Literature 1, in fluorescence correlation spectroscopy, laser light is guided to a cylindrical lens, and is thereby converted into a linear light beam. Further, the line-shaped light beam is vertically scanned by a galvanometer mirror, switched to two-dimensional scanning, and the entire sample is excited by irradiating the entire imaging area of the sample with excitation light, and the fluorescence signal is emitted. Is detected by a two-dimensional photodetector, and the respective light intensities in two dimensions are integrated. This method is a technique applied to a liquid sample in which fluorescent molecules have a low density.
[0005]
In such an observation method, the two-dimensional scanning by the galvanometer mirror is performed by two galvanometer mirror scanning mechanisms whose rotation directions are set at right angles to each other. Here, when acquiring an image of one sample, the entire region of the sample is scanned with one beam to acquire the image, so that one beam is scanned vertically and horizontally. Become. For this reason, it was difficult to acquire an image of the sample in a short time. In addition, since the galvano-mirror scanning mechanism has a mechanically movable portion such that the galvano-mirror vibrates at high speed (reciprocates), it is vulnerable to disturbances such as vibration, and precision adjustment (including temporal change). However, there are problems such as troublesome work and a limited mechanical life.
[0006]
[Non-Patent Document 1] "Confocal Microscopy" Wilson (ed.) Academic press (London)
[0007]
[Non-Patent Document 2] "Handbook of Biological Confocal Microscopy" B. Pawley (ed.) Plenum Press (New York)
[0008]
[Non-Patent Document 3] "Fluorescence correlation spectroscopy" Rigler, E .; S. Elson (eds.) Springer (Berlin)
[0009]
[Non-Patent Document 4] M. Goodwin etc. ACC. Chem. Res. (1996), Vol. 29, p607-613
[0010]
[Non-Patent Document 5] Masataka Kaneshiro, "Protein Nucleic Acid Enzyme" (1999) Vol. 44, no. 9, pp 1431-1437
[0011]
[Patent Document 1] Japanese Patent Application Laid-Open No. 2001-194303
[Problems to be solved by the invention]
In order to solve the above-described problems, an object of the present invention is to provide a light source device capable of two-dimensional scanning and further three-dimensional scanning with a simple mechanism, and a biomolecule analyzing device to which the light source is applied.
[0013]
[Means for Solving the Problems]
The present invention has taken the following measures in order to solve the above problems.
[0014]
The light source device according to the first aspect of the present invention is provided with a plurality of light sources two-dimensionally arranged on a plane and provided in correspondence with the plurality of light sources, and makes the light emitted from each of the plurality of light sources substantially parallel. And a plurality of optical members that are formed into a light beam and deflect in a predetermined direction.
[0015]
A biomolecule analyzing apparatus according to a second aspect of the present invention includes a light source device according to the first aspect, an optical system for guiding a light beam from the light source device to a sample, and light reflected by the sample or emitted from the sample. And a detector that detects the light and outputs an electric signal, and an output unit that outputs the electric signal as an image.
[0016]
BEST MODE FOR CARRYING OUT THE INVENTION
An embodiment of the present invention will be described with reference to the drawings.
FIG. 1 is a diagram for explaining a basic configuration of a biomolecule analyzing apparatus in explaining the present invention. The biomolecule analyzer shown in FIG. 1 is based on a laser scanning confocal optical microscope conventionally used. The laser scanning confocal optical microscope is described in, for example, JP-A-10-206742.
[0017]
In the biomolecule analyzer shown in FIG. 1, a minute measurement area is formed by a laser confocal optical system, and fluorescent molecules in a biological sample (cell) S existing in this measurement area are emitted from the laser light source 1. The laser beam is excited through the objective lens 5. Then, the fluorescence signal (photon pulse) obtained by this excitation, that is, the intensity fluctuation of the fluorescence, passes through the same optical system as the excitation optical system, passes through the dichroic mirror 7, and reaches the photodetector 10. The photon pulse is converted into a photocurrent pulse by the photodetector 10 and guided to a signal processing device (not shown) to perform waveform shaping, binarization processing, pulse counting, and the like. Desired. As a result, the translational diffusion speed of the fluorescent molecules and the like can be obtained.
[0018]
The first scanning system S1 is used for acquiring an image of the sample S. The laser beam is XY-scanned using a servo type galvano scanner (galvanometer mirror) including an X-axis scanning scanner and a Y-axis scanning scanner, and reflected light from the sample S held in a measurable state on the stage ST and Fluorescence is received by the photodetector 10 (measurement of the intensity of the optical signal), and image processing such as contrast enhancement and contour enhancement is performed by an image processing device. A two-dimensional image is obtained.
[0019]
The second scanning system S2 is used to obtain the autocorrelation function of the fluorescent molecules in the sample S. As shown in FIG. 1, XY scanning is performed with a laser beam using a galvano scanner 6. Then, the intensity fluctuation of the fluorescence from the fluorescent molecule is received by the photodetector 10, guided to a correlation analyzer, and an autocorrelation function is obtained by fluorescence correlation spectroscopy (FCS). From the autocorrelation function obtained here, statistical properties such as the speed of the translational diffusion movement of the fluorescent molecule and the change in the number of the fluorescent molecule in the measurement region are obtained.
[0020]
The specific operation of the biomolecule analyzer configured as described above will be described with reference to FIG.
The laser light emitted from the laser light source 1 is focused by the first lens 2. An illumination light pinhole 3 is arranged at the focus position. The position of the illumination light pinhole 3 is adjusted to the focus position of the second lens 4, and the collimated light (parallel light) is guided to the objective lens 5. The sample surface is adjusted to the focal position of the objective lens 5.
[0021]
The laser light emitted from the laser light source 1 is subjected to X-axis scanning and Y-axis scanning by an X-axis scanning scanner 61 and a Y-axis scanning scanner 62 whose scanning directions are orthogonal to each other. Are scanned two-dimensionally. The fluorescent signal from the fluorescent molecule in the sample S passes through the same optical path as the irradiated laser light and is reflected by the dichroic mirror 7 disposed between the second lens 4 and the illumination light pinhole 3. This reflected light passes through the light receiving pinhole 8 provided at the focal position of the second lens 4 and is guided to the light receiving lens 9. The dichroic mirror 7 has a spectral characteristic of transmitting irradiated laser light (excitation light) and reflecting fluorescence emitted from fluorescent molecules. The light receiving pinhole 8 is located at the focal position of the light receiving lens 9. The fluorescent light reaches the light detector (light receiver) 10 through the light receiving lens 9. As the photodetector 10, a two-dimensional photodetector such as a CCD camera for acquiring an image is used. An APD (avalanche photodiode), a photomultiplier, or the like is used to measure the intensity fluctuation of the fluorescence.
[0022]
In the biomolecule analyzing device as described above, the embodiment according to the present invention is characterized in that a planar light source device is provided as the laser light source 1. In the following embodiments, a case where the light source device is applied to a biomolecule analyzing device will be described. However, the present invention is not limited to this, and any device may be used as a light source for performing one-dimensional scanning or two-dimensional scanning. Is also applicable.
[0023]
(1st Embodiment)
The first embodiment will be described with reference to FIG. FIG. 3 is a schematic exploded perspective view of the light source device 100 according to the first embodiment of the present invention.
As shown in FIG. 3, the light source device 100 according to the first embodiment includes a surface array light source 112 having a plurality of light sources 114 formed in an array on a semiconductor substrate 110 and a light source device corresponding to the surface array light source 112. The micro-lens array 120 includes a plurality of micro-lenses 122 provided, and a micro-prism array 130 including a plurality of micro-prisms 132 provided corresponding to the surface array light source 112 (and the micro-lenses 122).
[0024]
In the above configuration, when light is emitted from the light source 114, the light travels while spreading, and enters the microlenses 122 provided corresponding to the light source 114 to become parallel light. The parallel light that has passed through the microlens 122 enters a microprism 132 provided corresponding to the microlens 122, is deflected in a desired direction, and the collimated light 140 is emitted from the light source device 100. As described above, the collimated light 140 is emitted by providing the microlenses 122 and the microprisms 132 as light flux controlling means for each light source 114. The entire element of the light source device 100 is configured so that each collimated light 140 spreads radially. In FIG. 3, the microlens array 120 and the microprism array 130 are arranged in this order from the surface array light source 112, but either one may be arranged on the surface array light source 112 side.
[0025]
FIG. 4 shows an embodiment in which the light source device 100 configured as described above is applied to a biomolecule analyzer. In FIG. 4, since the outline of the biomolecule analyzing apparatus is shown in FIG. 1, only main parts are shown, and the same parts as those in FIG.
[0026]
In FIG. 4, the light sources 114 arranged two-dimensionally are sequentially turned on and off in order to perform two-dimensional scanning. That is, in FIG. 4, for example, the light sources 114 of the planar array light sources 112 are turned on and off sequentially from the top. As a result, the sample S is sequentially scanned from the right to the left. When the light source 114 is sequentially turned on and off in the direction perpendicular to the plane of the paper, the sample S is scanned in the direction perpendicular to the plane of the paper. Therefore, the configuration of the light source device 100 according to the first embodiment enables two-dimensional scanning on the sample S.
[0027]
The reason is as follows.
When a certain light source 114 is turned on and off, a light beam from the light source 114 irradiates a specific portion of the sample S via the objective lens 5 when the light source 114 is turned on. Before the light beam is incident on the objective lens 5, the light flux is parallel to the incident direction on the objective lens 5, so that the sample S is focused on a specific position (a desired position). Therefore, it is possible to irradiate the sample S at a position corresponding to each light source 114 of the surface array light source 112. The reflected light from the sample S is guided to a photodetector 10 via an objective lens 5, a dichroic mirror 7, and a light receiving lens 9. Therefore, the intensity of the light beam reflected by the situation of the specific portion of the sample S is reflected on the magnitude of the output signal of the photodetector 10.
[0028]
By sequentially turning on and off the light source 114 as described above, the entire sample S can be scanned. Then, a microscope image can be obtained by converting the output signal of the photodetector 10 into an image signal waveform as luminance information and outputting it to an image display device such as a CRT (not shown). Note that an image sensor may be used instead of the photodetector 10. In this case, the image corresponding to the size of the light receiving unit of the image sensor is formed on the light receiving unit of the image sensor by the light receiving lens 9 (that is, the image forming optical system). A typical image sensor may be a solid-state image sensor such as a CCD or a CMOS sensor, or a sensor other than a semiconductor such as an image pickup tube.
[0029]
As described above, in addition to scanning all the light sources 114 of the surface array light source 112, scanning only the light sources 114 in a specific area, scanning by turning on and off every other light source 114, and various other methods. Scanning method can be easily realized.
[0030]
As the surface array light source 112, for example, application of a surface emitting semiconductor laser array is conceivable (see JP-A-5-55704, JP-A-11-204773, and JP-A-2002-374026).
The above-mentioned surface-emitting type semiconductor lasers include those having a wavelength of 0.7 to 0.8 μm of GaAs, blue to ultraviolet regions of GaN, a GaAs surface emitting array having a diameter of 10 μm and a pitch of 20 μm, and a DBR surface emitting laser. Arrays in which one million pieces are arranged on the same substrate have already been reported (Kenichi Iga: surface emitting semiconductor laser) or are commercially available. In the present invention, it is considered that a surface emitting semiconductor laser array having a pitch of 50 μm and about 100 × 100 and having a wavelength of about 780 μm or a blue to ultraviolet region and about φ20 μm can be realized.
[0031]
(Modification of First Embodiment)
In the first embodiment, the light source device 100 includes the surface array light source 112, the micro lens array 120, and the micro prism array 130. However, the micro lens array 120, the micro prism array 130, May be formed as one element.
[0032]
FIG. 5 shows a modification in which the same operation as that of the first embodiment is performed using a modified microlens array 125 instead of the microlens array 120 and the microprism array 130. In FIG. 5, the same portions as those in FIGS. 3 and 4 are denoted by the same reference numerals, and detailed description thereof will be omitted. One of the individual microlenses of the deformed microlens array 125 is swelled so that an angle is generated between the left and right optical axes. Each deformed microlens array 125 having such a shape is optically equivalent to a combination of the microlens array 120 and the microprism array 130 in the embodiment of FIG. Therefore, the configuration according to FIG. 5 requires only two optical elements.
[0033]
(Second embodiment)
A second embodiment will be described with reference to FIG. FIG. 6 is a diagram illustrating an embodiment in which the light source device 100 according to the second embodiment is applied to a biomolecule analyzer. In FIG. 6, the same parts as those in FIGS. 3 and 4 are denoted by the same reference numerals, and detailed description thereof will be omitted. In the second embodiment, an embodiment is described in which the sample S is scanned not in a direction perpendicular to the optical axis but in a direction parallel to the optical axis.
As shown in FIG. 6, in the second embodiment, the microlenses 122 of the microlens array 120 are configured such that, for example, the microlenses 122 sequentially increase the deflection amount (that is, the spread of the light beam) from the top. Since the top microlens 122 has the widest luminous flux, it focuses on the deepest position of the sample S, and the bottom microlens 122 has the narrowest luminous flux. , The focal point is closest to the objective lens 5 side. The microprism array 130 is inserted for correcting the focal position. With such a configuration, the microprisms 132 are arranged such that their focal positions are linearly arranged along the optical axis. Note that the second embodiment is combined with the first embodiment and its modifications to form an array in which the XY directions of the microprisms 132 and the focal position correction can be simultaneously changed, and a specific surface array corresponding thereto. By turning on the light source, three-dimensional scanning becomes possible.
[0034]
(Third embodiment)
A third embodiment will be described with reference to FIG. FIG. 7 is a block diagram of a biomolecule analyzing apparatus according to the third embodiment of the present invention. The biomolecule analyzer according to the present embodiment includes a two-dimensional scanning mechanism using the light source device 100 including the surface array light source 112 and the photodetector 10.
[0035]
As shown in FIG. 7, in the light source device 100, only the specific light source 114 emits light (ON / OFF) by the drive circuit 50. Light emitted from each light source 114 is reflected by the dichroic mirror 7 and enters the sample S via the objective lens 5. The reflected light (or fluorescent light; hereinafter, referred to as “reflected light” for convenience) from the sample S enters the photodetector 10 via the dichroic mirror 7 and the light receiving lens 9. The reflected light detected by the photodetector 10 is converted into an electric signal and output to the signal processing circuit 20. The signal processing circuit 20 converts an output signal from the photodetector 10 into a luminance information signal that can be processed by an image signal generation circuit 30 disposed at a subsequent stage. The image signal generation circuit 30 receives the luminance information signal from the signal processing circuit 20 and the coordinate signal from the drive circuit 50, and matches the observation region of the sample S (that is, the scanning region with the light source 114) with the display image. The image signal is created as follows. The image display unit 35 (for example, a TV monitor) receives the image signal from the image signal generation circuit 30 and displays an image based on the image signal. The image display unit 35 includes, as an image output unit, any of a printing device and other output devices in addition to the TV monitor.
[0036]
(Fourth embodiment)
The fourth embodiment will be described with reference to FIG. FIG. 8 is a block diagram of a biomolecule analyzing apparatus according to the fourth embodiment of the present invention. The biomolecule analyzing apparatus according to the fourth embodiment includes a two-dimensional scanning mechanism using the surface array light source 112 of the light source device 100 and an image sensor. In FIG. 8, the same portions as those in FIG. 7 are denoted by the same reference numerals, and detailed description will be omitted.
[0037]
The fourth embodiment differs from the third embodiment in that an image sensor 25 is used instead of the photodetector 10. The size of the image is adjusted by the light receiving lens 9 so that the image is formed on the image sensor 25 in this manner. Then, the signal output from the image sensor 25 is generated by the image signal generation circuit 30 in the same manner as in the third embodiment, and an image of the sample S is displayed on the image display unit 35 based on the image signal. Is done. Thus, an image of the sample S can be obtained.
[0038]
The fluorescence correlation analysis can be performed by exciting the fluorescent dye in the sample S through the objective lens by the light beam from the light source 114 of the surface array light source 112.
[0039]
(Fifth embodiment)
The fifth embodiment will be described with reference to FIG. FIG. 9 is a block diagram of a biomolecule analyzing apparatus according to the fifth embodiment of the present invention. The fluorescence correlation analysis can be realized by the two-dimensional scanning mechanism using the planar array light source 112 in the biomolecule analyzer according to the fifth embodiment. In FIG. 9, the same parts as those in FIGS. 7 and 8 are denoted by the same reference numerals, and detailed description thereof will be omitted.
[0040]
In the fourth embodiment, the image signal generation circuit 30 receives signals from the drive circuit 50 and the signal processing circuit 20 and appropriately displays an image at a coordinate position corresponding to the light source 114 turned on by the drive circuit 50. However, in the present embodiment, the computer 40 is provided, and the computer 40 performs various controls and calculations. With such a configuration, both the observation such as the correlation analysis according to the third embodiment and the image observation according to the fourth embodiment can be realized.
[0041]
In the configuration of the present embodiment, when exciting the fluorescent dye molecules in the sample S, the following various methods can be appropriately applied. (1) a method in which all the light sources 114 of the surface array light source 112 are simultaneously turned on to excite all desired fluorescent dye molecules, (2) a method in which the lighting locations are sequentially switched to excite the fluorescent dye molecules, or (3) Various excitation methods can be applied, such as a method of lighting only one or a plurality of necessary light sources. Then, the fluorescence emitted from the fluorescent dye of the sample S is detected by the photodetector 10, and a photoelectron pulse signal or a photocurrent based on the intensity fluctuation is output. The output signal from the photodetector 10 is subjected to waveform shaping, binarization processing, pulse counting, and the like in a signal processing circuit 20. Then, the signal processed by the signal processing circuit 20 is guided to a computer to perform a fluorescence correlation analysis. In addition, a scanning method (such as tracking) in which excitation of the fluorescent dye is continued in an optimum state while feeding back the observation image is also possible.
[0042]
The following inventions are extracted from the above embodiments.
[0043]
The light source device according to the first aspect of the present invention is provided with a plurality of light sources two-dimensionally arranged on a plane and provided in correspondence with the plurality of light sources, and makes the light emitted from each of the plurality of light sources substantially parallel. And a plurality of optical members that are formed into a light beam and deflect in a predetermined direction.
[0044]
Preferred embodiments of the above light source device are as follows. In addition, each of the following embodiments may be applied independently or may be applied in an appropriate combination.
(1) Each of the optical members includes a microlens that converts light from the light source into a substantially parallel light beam, and a microprism that deflects light from the light source.
[0045]
(2) Each of the optical members has a microlens that converts light from the light source into a substantially parallel light flux and deflects the light from the light source.
[0046]
(3) The plurality of optical members include a microlens for shaping the light so that a light beam from the light source spreads differently.
[0047]
(4) A light beam from one of the plurality of light sources is focused on a predetermined area in the sample.
[0048]
(5) A light beam from one of the plurality of light sources is focused on a predetermined position along the observation optical axis.
[0049]
(6) In the plurality of light sources, a predetermined region or all light sources are turned on and off simultaneously and in a predetermined order.
[0050]
(7) The plurality of optical members are at least one of a different portion in the sample and a different position among positions along the observation optical axis by light emission from light sources arranged at different positions among the plurality of light sources. Be configured to focus on
[0051]
The biomolecule analyzing apparatus according to the second aspect of the present invention includes a light source device according to the first aspect, an optical system that guides a light beam from the light source device to a sample, and light reflected by the sample or the sample. It is characterized by comprising: a detector that detects emitted light and outputs an electric signal; and an output unit that outputs the electric signal as an image. Note that, in the second aspect, it is preferable that the apparatus further includes an analysis unit that analyzes a detection result detected by the detector, and the output unit outputs an analysis result by the analysis unit.
[0052]
Note that the present invention is not limited to the above embodiment of the present invention. It goes without saying that various modifications can be made without departing from the scope of the present invention. For example, in the above-described embodiment, measurement using fluorescence correlation spectroscopy has been described as an example, but the present invention is not limited to this. That is, the present invention provides an arbitrary micro-optical measurement for measuring various optical characteristics (polarization, scattering, electrochemiluminescence, resonance energy transfer, plasmon resonance, etc.) limited to a specific site or a specific region of a sample to be measured. Applicable to The image to be acquired is not limited to a temporary two-dimensional or three-dimensional image, but may be a still image or a video image over a plurality of hours. Also, the sample holding means may be a cell or any other component capable of appropriate optical holding (a container, a solution component, a temperature controller, an optical element material, etc.).
[0053]
【The invention's effect】
By applying the light source device according to each embodiment of the present invention to a biomolecule analyzing device, two-dimensional scanning, and even three-dimensional scanning of a sample can be performed with high accuracy, high speed, high reliability, and high functionality with a simple mechanism. be able to.
[Brief description of the drawings]
FIG. 1 is a diagram for explaining a basic configuration of a biomolecule analyzing apparatus.
FIG. 2 is a diagram for explaining a specific operation of the biomolecule analyzing apparatus.
FIG. 3 is a schematic exploded perspective view of the light source device 100 according to the first embodiment of the present invention.
FIG. 4 is a diagram showing an embodiment in which the light source device 100 according to the first embodiment is applied to a biomolecule analyzer.
FIG. 5 is a view showing a modification of the first embodiment.
FIG. 6 is a diagram showing an embodiment in which the light source device 100 according to the second embodiment is applied to a biomolecule analyzing device.
FIG. 7 is a block diagram of a biomolecule analyzing apparatus according to a third embodiment of the present invention.
FIG. 8 is a block diagram of a biomolecule analyzing apparatus according to a fourth embodiment of the present invention.
FIG. 9 is a block diagram of a biomolecule analyzing apparatus according to a fifth embodiment of the present invention.
[Explanation of symbols]
Reference Signs List 100 light source device 110 semiconductor substrate 112 surface array light source 114 light source 120 microlens array 122 microlens 125 deformed microlens array 130 microprism array 132 microprism

Claims (8)

A plurality of light sources arranged two-dimensionally on a plane,
A plurality of optical members provided corresponding to the plurality of light sources, and configured to form light emitted from each of the plurality of light sources into substantially parallel light beams and to deflect the light in a predetermined direction. Light source device. The light source device according to claim 1, wherein each of the optical members includes a microlens that converts light from the light source into a substantially parallel light flux, and a microprism that deflects light from the light source. Light source device. 2. The light source device according to claim 1, wherein each of the optical members includes a microlens that converts the light from the light source into a substantially parallel light flux and deflects the light from the light source. 2. The light source device according to claim 1, wherein the plurality of optical members include a microlens for shaping the light so that a light beam from the light source spreads differently. 3. 5. The light source device according to claim 1, wherein the plurality of light sources are turned on / off in a predetermined area or in all of the light sources simultaneously and in a predetermined order. 6. 6. The light source device according to claim 1, wherein the plurality of optical members are different portions in the sample due to light emission from light sources arranged at different positions among the plurality of light sources. 7. And a light source device configured to focus on at least one of different positions along the observation optical axis. A light source device according to any one of claims 1 to 6,
An optical system for guiding a light beam from the light source device to the sample,
A detector that detects light reflected by the sample or light emitted from the sample, and outputs an electric signal;
A biomolecule analyzing apparatus, comprising: an output unit that outputs an electric signal as an image. The biomolecule analyzing apparatus according to claim 7, further comprising an analysis unit configured to analyze a detection result detected by the detector.
The biomolecule analyzing apparatus, wherein the output unit outputs an analysis result obtained by the analysis unit.

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