JP2004352702A - Fat metabolism-accelerating agent or fat metabolism-accelerating food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a fat metabolism-accelerating agent or fat metabolism-accelerating food, dissolving obesity, accelerating the fat metabolism for aiming at a healthy life and also having no adverse effect. <P>SOLUTION: This fat metabolism-accelerating agent or food is provided by blending an extract obtained by extracting rice bran obtained from colored unpolished rice and/or colored rice with a hydrophilic organic solvent and/or water. Further by blending ≥1 kind of plants of the genus Garcinia and Gymnema or their extracts, amino acids, peptides, it is confirmed that the effect of the agent is widely improved. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

【００２８】
次に人で実験した。５０人を１０人づつに群分けし、実施例１から４および比較例を１日３回３錠づつ６月間摂取してもらった。実験の前後に体重と体脂肪率を測定した。（タニタ製内臓脂肪チェック付き脂肪計インナースキャンＴＦ−７３０）それぞれの平均値を表２に記す。
【００２９】
【表２】

【００３０】
【効果】動物実験でも、血中の脂肪関係の測定値が減少し、人で実験しても体重も減少するが、体脂肪率は比較例に比較して大きく低下し脂肪代謝促進剤または脂肪代謝促進食品として高い効果を見出した。[0001]
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fat metabolism promoter or a fat metabolism promoting food which promotes fat metabolism and produces a healthy body.
[0002]
2. Description of the Related Art At present, it is said that the age of satiety is inevitable, and meals can be taken without difficulty. As a result, the number of obese people is increasing. However, diets such as excessive dietary restrictions can impair physical and mental health. Garcinia, gymnema, etc. are known as those having a diet-in particular fat metabolism promoting action.
[0003]
DISCLOSURE OF THE INVENTION The present inventors find a fat metabolism promoter or a fat metabolism promoting food which eliminates obesity, promotes fat metabolism for a healthy life, and has no harmful side effects. It is in.
[0004]
Means for Solving the Problems As a result of intensive studies by the present inventors, the present inventors have paid attention to colored rice such as black rice and red rice, which has been eaten in celebration seats and anniversaries since ancient times in Japan. Today's rice is natural and contains many useful ingredients, unlike the rice, which has less active ingredients such as vitamins and minerals as a result of pursuing higher yields and deliciousness, and which does not grow unless a large amount of pesticides are used. Studied rice. As a result, it was found that the bran portion of the ancient rice contains a component that solves the problem of the present invention. However, since the active ingredient is present in the bran part, the effect of milling ancient rice is drastically reduced and the only effect is to eat brown rice, but if brown rice remains, it will not satisfy the taste of modern people. No, and the result is a high intake of carbohydrates contained in endosperm and the like. As a result of various studies, the present inventors have found that the problem can be solved by using a component extracted with a hydrophilic organic solvent and / or water.
[0005]
Although there is no particular limitation on the hydrophilic organic solvent used for this extraction, it is necessary to include a step of completely removing the hydrophilic organic solvent after extraction for those that have a bad effect on the human body. It is. That is, it is preferable to extract with ethanol, water, or a mixture of ethanol and water. Furthermore, ethanol: water = 3: 1 to 1: 3 is more preferable. To this solution is added a brown rice of colored rice (in the case of brown rice, shred or pulverize as necessary) or an extraction solvent of bran by 2 to 100 times by weight, followed by stirring and heating as necessary. The extraction time varies depending on the state of heating and the like, but requires about 30 minutes to 5 days. In addition, if a reflux condenser is attached and the heating temperature is increased, the extraction time can be shortened. In addition, the extraction solvent is removed depending on the application. As for the removal method, the extraction solvent is removed by a known method such as heating, concentration under reduced pressure, and freeze-drying (in this case, it is preferable to remove ethanol to some extent before carrying out).
[0006]
This may be used as it is as a fat metabolism promoter or a fat metabolism promoting food (drink), but it is also possible to select other ingredients to make it easier to ingest.
Among other raw materials, amino acids, peptides, garcinia, and gymnema can further enhance the effects of the present invention to obtain more effective fat metabolism promoters or fat metabolism promoting foods (drinks).
Amino acids and peptides have recently been studied, and among the 20 types of amino acids required by humans, lysine, proline, alanine, arginine, and ortinine are found to be diet amino acids particularly useful for fat burning. In addition, it has been studied that peptides and the like containing a large amount of these have a slimming effect, and 2 to 20 peptides are used as the number of amino acids obtained by hydrolyzing proteins such as silk, soybeans, and sardines.
[0007]
The Gymnema plant is a potato family, a vine plant that grows in tropical and subtropical regions, and grows in clinging trees on rocky hills. It has been applied to diabetes for 2000 years in India, and is now widely used as a diet food in Japan. Although some Gymnema plants are used, Gymnema sylvestre, Gymnema inodrum and the like are widely used.
[0008]
Garcinia cambogia, a scientific name, is a plant of the same genus as mangosteen, a plant that grows naturally in southwestern India, Sri Lanka, Thailand, etc., is an evergreen tree, and its fruit is used as a raw food or dried as a seasoning. . In addition, it contains hydroxycitric acid (HCA), and is considered to have a body fat decomposition promoting effect and an appetite suppressing effect in Japan in recent years, and is used for dieting.
[0009]
When these are blended, the effect of the present invention is dramatically increased, and therefore, they are used after being subjected to processing such as extraction as necessary.
[0010]
If necessary, add other raw materials such as vitamins, minerals, royal jelly, ginseng, propolis, honey, dietary fiber, collagen, etc. to make any dosage form of powder, granules, tablets, capsules, liquids, and fat metabolism. Create an accelerator.
Soft drinks, carbonated drinks, nutritional drinks, fruit drinks, lactic acid drinks and other beverages, jellies, candies, etc., can also be used as fat metabolism promoting foods, and can also be mixed with milk, curry, stews, etc. It is also possible to eat and drink. However, it is natural to avoid using a large amount of raw materials and foods contrary to the gist.
The extract, amino acid and peptide obtained by extracting bran obtained from colored rice brown rice and / or colored rice with a hydrophilic organic solvent and / or water are not particularly limited in amount, but are not limited to Garcinia, Gymnema plants or these. It goes without saying that the extract should be formulated to give a proper intake.
[0011]
EXAMPLES The present invention will be described in detail below with reference to examples, but it is needless to say that the present invention is not limited by the examples. In addition, the Example was created by the usual method.
[0012]
Example 1 Tablets 2000 g of red rice bran extract, 500 g of lactose, 300 g of corn starch, 300 g of carboxymethylcellulose, 200 g of methylcellulose, and 50 g of magnesium stearate were mixed and tabletted to prepare a tablet of 500 mg per tablet.
[0013]
Example 2 Tablets 2000 g of red rice bran extract, 500 g of gymnema extract, 500 g of lactose, 300 g of corn starch, 300 g of carboxymethylcellulose, 200 g of methylcellulose, and 50 g of magnesium stearate were mixed and tabletted to prepare one tablet of 500 mg.
[0014]
Example 3 Tablets 2000 g of red rice bran extract, 500 g of garcinia extract, 500 g of lactose, 300 g of corn starch, 300 g of carboxymethylcellulose, 200 g of methylcellulose and 50 g of magnesium stearate were mixed and tabletted to prepare one tablet of 500 mg.
[0015]
Example 4 Tablets 2000 g of red rice bran extract, 100 g of lysine, 100 g of proline, 100 g of alanine, 100 g of arginine, 100 g of ortinine, 500 g of lactose, 300 g of corn starch, 300 g of carboxymethylcellulose, 200 g of methylcellulose, and 200 g of magnesium stearate were mixed and tableted. One tablet of 500 mg was prepared.
[0016]
Example 5 Beverage Red rice bran extract 2 g, arginine 2 g, alanine 2 g, caffeine 50 mg, vitamin C 5 g, vitamin B2 5 mg, vitamin B6 5 mg, nicotinic acid 50 mg, maltitol 5 g, aspartame 50 mg to 100 mL with purified water. It was adjusted.
[0017]
Example 6 Drinking Red Rice Bran Extract 2g, Gymnema Extract 2g, Garcinia Extract 2g, Caffeine 50mg, Vitamin C 5g, Vitamin B2 5mg, Vitamin B6 5mg, Nicotinic Acid 50mg, Maltitol 5g, Aspartame 50mg to 100mL with Purified Water Was adjusted as follows.
[0018]
Example 7 Beverage Red rice bran extract 2 g, gymnema extract 2 g, arginine 2 g, alanine 2 g, caffeine 50 mg, vitamin C 5 g, vitamin B2 5 mg, vitamin B6 5 mg, nicotinic acid 50 mg, maltitol 5 g, aspartame 50 mg and purified water to 100 mL It was adjusted to become.
[0019]
Example 8 Cookie Red rice bran extract 15 g, Garcinia extract 20 g, strong flour 100 g, soft flour 50 g, 1/4 teaspoon baking powder, butter 50 g, a little salt, one egg white, water and an appropriate amount of diet cookies (approx. 50 servings) ) Manufactured.
[0020]
Example 9 15 g of cookie red rice bran extract, 20 g of soy peptide, 10 g of lysine, 10 g of proline, 10 g of alanine, 10 g of arginine, 10 g of ortinin, 100 g of flour, 50 g of flour, 1/4 teaspoon of baking powder, 50 g of butter, a little salt, 1 egg white And an appropriate amount of water were added to produce a diet cookie (about 60 pieces).
[0021]
Example 10 15 g of cookie red rice bran extract, 20 g of soybean peptide, 2 g of gymnema extract, 2 g of garcinia extract, 100 g of flour, 50 g of flour, 1/4 teaspoon of baking powder, 50 g of butter, a little salt, 1 egg white, and an appropriate amount of water To produce diet cookies (about 50 pieces).
[0022]
The red rice bran extract used in the above examples was prepared as follows.
To 100 g of red rice bran, 1 L of 50 (V / V)% ethanol was added, and a reflux condenser was attached, followed by reflux at 80 ° C. for 3 hours. Thereafter, the mixture was filtered through filter paper (Toyo Filter Paper No. 5C), and the filtrate was concentrated. The concentrate was freeze-dried to obtain 10 g of red rice bran extract.
[0023]
Gymnema extract used in the above examples was prepared as follows.
To 100 g of Gymnema sylvesta leaves, 1 L of 50 (V / V)% ethanol was added, and a reflux condenser was attached, followed by reflux at 80 ° C. for 3 hours. Thereafter, the mixture was filtered through filter paper (Toyo Filter Paper No. 5C), and the filtrate was concentrated. The concentrate was freeze-dried to obtain 10 g of Gymnema extract.
[0024]
Garcinia extract used in the above examples was prepared as follows.
One liter of 50 (V / V)% ethanol was added to 100 g of the pericarp of Garcinia Cambodia, and a reflux condenser was attached, followed by reflux at 80 ° C. for 3 hours. Thereafter, the mixture was filtered through filter paper (Toyo Filter Paper No. 5C), and the filtrate was concentrated. The concentrate was freeze-dried to obtain 10 g of Garcinia extract.
[0024]
The soybean peptide used in the above examples was Fuji Oil Co., Ltd., trade name, "Soybean Peptide Hineute".
[0025]
The following tests were performed to confirm the effects.
Wistar rats (male, 4 weeks old, after one week of preliminary breeding) were bred at room temperature 23 ± 1 ° C., humidity 50 ± 5%, and in a dark environment from 9:00 am to 9:00 pm.
The 19 animals were divided into 4 groups, the first group (5 animals) and the second group (4 animals) were a normal diet (CE-2 manufactured by Oriental Yeast Co., Ltd.), and the third group (5 animals) and the 4th group (5 animals) ) Was allowed to freely ingest a feed containing 10% of CE-2 Production Example 1 manufactured by Oriental Yeast Co., Ltd. In addition, tap water was freely provided.
While bred under the above conditions, for the second and fourth groups, running training at a running speed of 23 m / min was performed for one hour per day using a treadmill for small animals (KN-73 manufactured by Natsume Seisakusho). Conducted 5 days a week. This was done for 8 weeks (running was done in the dark).
After a 12-hour fast, the abdomen was opened under ether anesthesia, blood was collected from the aorta of the lower leg, and allowed to stand at 4 ° C. for 30 minutes.
Total lipid, T-chol (total cholesterol), TG (neutral fat), HDL, and phospholipid were measured.
[0026]
The results are shown in Table 1 below.
[0027]
[Table 1]

[0028]
Next, we experimented with humans. Fifty people were divided into groups of ten, and Examples 1 to 4 and Comparative Example were ingested three tablets three times a day for 6 months. Body weight and percent body fat were measured before and after the experiment. Table 2 shows the average value of each (Fatometer inner scan TF-730 with visceral fat check manufactured by Tanita).
[0029]
[Table 2]

[0030]
[Effect] In animal experiments, the measured value of blood-related fat decreases, and even in human experiments, the body weight also decreases, but the body fat percentage is greatly reduced as compared with the comparative example, and the fat metabolism promoting agent or fat A high effect was found as a metabolism promoting food.

Claims (2)

Fat metabolism promoter or fat metabolism promoting food containing an extract obtained by extracting bran obtained from colored rice brown rice and / or colored rice with a hydrophilic organic solvent and / or water 2. The fat metabolism promoter or fat metabolism promotion food according to claim 1, further comprising at least one of a plant of the genus Garcinia or Gymnema or an extract, amino acid, or peptide thereof.