JP2003335623A - Skin care preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use, excellent in inhibition of skin chapping and skin aging symptom and having prevention and improvement effects on lipid peroxide production, skin inflammation and skin chapping each caused by active oxygen formation in the skin. <P>SOLUTION: This skin care preparation for external use is obtained by containing a Salicaceae plant extract and one or more kinds selected from usually utilized antioxidants such as carotenoids, flavonoids, tannins, gallic acid and its salts and esters, tocopherol and its derivatives, superoxide dismutase, thioredoxin, thioredoxin reductase, butyl hydroxytoluene and butyl hydroxyanisole. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has an excellent effect of preventing rough skin and aging of the skin, and has the effect of preventing or improving lipid peroxide generation due to active oxygen generation in the skin, and skin inflammation and rough skin. The present invention relates to a skin external preparation. More specifically, it relates to a skin external preparation containing a Salicaceae plant extract and one or more selected from antioxidants.

[0002]

2. Description of the Related Art As the adverse effects of oxidative stress caused by ultraviolet rays and endogenous oxygen on the skin have been revealed, application of substances having an antioxidant effect to external preparations for skin has been investigated. Typical examples of these antioxidant substances include antioxidant vitamins such as vitamin Es and vitamin Cs.

However, the above-mentioned antioxidative vitamins are unstable to light and oxidants, and even the derivatives having improved stability do not have sufficient antioxidative activity, and therefore, they have been incorporated into a skin external preparation. In order to obtain a sufficiently effective effect, a considerably high concentration is required, and depending on the dosage form of the external preparation, formulation may be difficult due to solubility problems, or formulation stability may be adversely affected.

[0004]

[Problems to be Solved by the Invention] The antioxidative effect is synergistically enhanced, and the effect of antioxidative components is fully exerted by the addition of a small amount, and the effect of preventing rough skin and aging of the skin is excellent, and the active oxygen in the skin is active. The object was to obtain an external preparation for the skin, which has the effect of preventing or ameliorating the generation of lipid peroxide, the skin inflammation, and the rough skin caused by the generation.

[0005]

[Means for Solving the Problems] As a result of various studies to solve the above problems, the present inventors found that the Salicaceae family
ae ) One or two selected from plant extracts and antioxidants
It has been found that the combined use of one or more of these with an external skin preparation synergistically enhances the antioxidant effect of the antioxidant component, and that a small amount of the compound can sufficiently exert the antioxidant effect. Has been completed.

Regarding the effectiveness of Salicaceae plant extracts, the whitening effect of dihydromyricenan contained in leaves (JP-A-63-316711) and anti-mutagenic effect (JP-A-1-175932), bark extraction It is already known that the histamine release-inhibiting effect of the product (JP-A-10-287582), the fibroblast activation effect of salicin contained in the bark and leaves in large amounts (JP-A-11-80002), and the like.

Regarding the antioxidant, the production of lipid peroxide due to the production of active oxygen in the skin, the inflammation of the skin,
Expect the effect of preventing or improving skin roughness, it has been incorporated into skin external agent for a long time, Salicaceae (Salicace
ae ) The effect of the present invention obtained by using a plant extract in combination with an antioxidant has not been suggested at all.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Willow family ( Salica) used in the present invention
ceae ) plants include Chosenia arbutifolia (Pallas) A. Skvortz; Ch.
osenia bracteosa Nakai), cottonwood willow ( porcupine ,
Poplar) the genus of cottonwood (Populus) (Populus siebo
ldi Miq.), Dero ( Populus maxmowiczii He
nry), Populus alba
L.), American Poppy ( Populus deltoides Mars
h .; Populus monilifera Ait .; Populus angulata Ai
v.), populus euphratica (Populus euphratica Oliv.), Europe Black Mountain break-in (Populus nigra L.), Populus nigra (Populus nigra var. italica Koehne) , Europe mountain leveling (Populus tremula), Salix of Kasupiyanagi (Salix acutifolia L.) , European willow
(Salix alba L .; Salix aurea Salisb .), Salix (Itoyanagi) (Salix babylonica L.), wildcat willow (Bakkoyanagi) (Salix bakko Kimura), Akameyanagi (Salix chaenomeloides Kimura), Naga bus sallow
( Salix gilgiana Seemen.), Pussy willow (Enoco willow, river willow) ( Salix gracilistyla Miq.), Dogwood willow ( Salix integra Thunb.), Willow tree ( Salix j
aponica Thunb.), Salix kinuyanagi Kimur
a), Koryanagi ( Salix koriyanagi Kimura; Salix pur
purea var. japonica Nakai), Frisode willow ( Salix l
eucopithecia Kimura), Salix matsu
dana Koidz.), Japanese willow tree
( Salix nakamurana Koidz.), Salix nigr
a ), Salix purpurea L., Salix purpurea L., Salix sachalinensis Fr. Sch
m.), willow tree ( Salix reinii Fr. e)
t Sav.), Salix sieboldiana Bl., Salix viebalis L .; Salix longifolia
Lam.), Fox willow ( Salix vulpin )
a), Oobayanagi genus Oobayanagi (Toisusu urbaniana
Salix urbaniana ), etc. are exemplified. Among these, especially from the viewpoint of its antibacterial action, the European porcupine ( Pop
ulus tremula ), willow ( Salix alba L .; Sa
lix aurea Salisb.), Salix (Itoyanagi) (Sal
ix babylonica L.), black willow ( Salix nigra ), purple willow ( Salix purpurea L.)
It is preferred to use more than one plant, and most preferred is Salix nigra bark extract. The site for obtaining an extract from a Salicaceae plant is not particularly limited, but a bark, a leaf and a female flower are preferably used in view of its antibacterial action.

Extraction solvents for obtaining the extracts of these Salicaceae plants include water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol,
Alcohols such as n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether,
Propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol and other polyhydric alcohols or their derivatives, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl-n-propyl Ketones such as ketones, esters such as ethyl acetate and isopropyl acetate,
One or more mixed solvents selected from polar solvents such as ethers such as ethyl ether, isopropyl ether, n-butyl ether, etc. can be preferably used, and phosphate buffered saline can also be used. However, it is not particularly limited. For the purpose of the present invention, a polar solvent is preferable from the viewpoint of antibacterial activity, and further, one or more mixed solvents selected from methanol, ethanol, 1,3-butylene glycol, and water, particularly water, may be used. It is preferably used as a solvent.

As the extraction method, a method of immersing at room temperature, cooling or heating, extraction using a distillation method such as steam distillation, and a raw Salixaceae
Examples of the method include a pressing method of pressing a plant to obtain an extract, and these methods are used alone or in combination of two or more kinds.

[0011] Without being limited especially Salicaceae (Salicaceae) the ratio of plant and solvent used in the extraction, solvent for Salicaceae (Salicaceae) Plant 1 0.5 to 1000
The weight is preferably 0.5 to 100 times, particularly in terms of extraction operation and efficiency. Further, the extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent or less under normal pressure, and the extraction time is preferably in the range of 2 hours to 2 weeks, although it varies depending on the extraction temperature and the like.

The Salicaceae plant extract thus obtained can be used as it is, but it can be used for deodorizing, decolorizing, concentrating, etc. within the range of not losing the antibacterial effect of the present invention. It may be used as a fractionated product by adding a purification operation or further using column chromatography or the like. These extracts, purified products, and fractions can be made into a dry solid by removing the solvent from them, and can be provided in the form of being solubilized in a solvent such as alcohol, or in the form of an emulsion. it can. The content of these Salicaceae plant extracts in the external preparation for skin is generally 0.001 to 10% by weight, preferably 0.1 to 10% by weight.
5% by weight is suitable.

The antioxidant to be used in the present invention may be of any kind and may be of any origin, so long as it can be incorporated into a skin external preparation. For example, carotenoids, flavonoids, tannins and gallic acid and salts thereof can be used. In addition, esters, tocopherols and their derivatives, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like are used. Alternatively, a plant extract, an algae extract, or a yeast extract having an antioxidant effect may be used.

The carotenoids used in the present invention, regardless of type or origin, are α-carotene, β-carotene,
γ-carotene, lycopene, cryptoxanthin, lutein (xanthophyll), zeaxanthin, rhodoxanthin, crocetin and the like are exemplified. Moreover, these carotenoids may be used as they are, but derivatives such as glycosides and esters may also be used.

The flavonoids used in the present invention, regardless of type or origin, include flavones, chrysin, primetin, apigenin, luteolin and other flavones and flavone glycosides, galangin, kaempferol, fisetin, quercetin, myricetin, Flavonol and flavonol glycosides such as rutin, isoflavone and isoflavone glycosides such as daidzein and genistein, flavanone,
Flavanone and flavanone glycosides such as pinocembrin, naringenin, sakuranetin, hesperetin, eriodictyol, and matisinol, flavanonol, pinobanksin, aromadendrin, fustin, taxifolin, flavanonol glycosides, chalcone, and the like. Chalcone and chalcone glycosides such as butein, chalcone cartamidine, pedicin and pedicinin, benzalcumalanone and benzalcumalanone glycosides such as benzalcumalanone, sulfuretin, leptocidin and auroidin, pelargonidin, cyanidin and delphinidin And the anthocyanin glycosides.

The tannins used in the present invention are tannic acids in a broad sense, which are present in many plants, especially bark of beech plants such as oak and oak, leaves of plants such as goby, nulde and sumac, and fruits of Kariroku. It is also called gallotannin or gallotannin acid. Tannins are a general term for these complex aromatic compounds having a large number of phenolic hydroxyl groups widely distributed in the plant kingdom. Phenols and phenolcarboxylic acids are obtained by alkali decomposition. In the present invention, these plant-derived tannins may be used as they are or after being purified, and artificially synthesized ones may also be used. In addition, gallic acid and its salts, which are the constituents of tannin, and its esters can also be used. Among these tannins,
Most preferably, Hamamelitannin contained in Hamamelis extract is used.

The tocopherol and its derivatives used in the present invention are not particularly limited, and α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, tocopherol acetate, DL-α-nicotinate.
Examples include tocopherol and DL-α-tocopherol succinate.

In the present invention, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like may be added as other antioxidant components.

In the present invention, plant extracts, algae extracts and yeast extracts having an antioxidant effect can also be used. Such plant extracts and algae extracts include green tea extract, oolong tea extract, black tea extract, hamamelis extract, birch extract, clove extract, oleander extract, rosemary extract, sage extract, clove extract. Examples thereof include an extract, a thyme extract, an oregano extract, a sesame extract, a ginkgo extract, a microalgal extract, and a mozuku extract. As these, those commercially available as raw materials for cosmetics and pharmaceuticals can be used.

In the present invention, one of the above antioxidant components may be used alone or two or more of them may be used in combination. Further, the amount of these antioxidant components to be added to the external preparation for skin depends on the antioxidant activity of each antioxidant component,
About 0.00001 to 5% by weight, preferably 0.000
1-5% by weight is suitable.

The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders and granules. In addition, skin cosmetics such as lotion, emulsion, cream, beauty essence, pack,
Makeup base lotion, make-up base cream and other base cosmetics, foundation of each dosage form such as milky liquid, oily and solid form, eye color, cheek color and other make-up cosmetics, hand cream, leg cream, neck cream , Can be provided as body cosmetics such as body lotion.

The external preparation for skin according to the present invention includes oily components, surfactants, humectants, pigments, ultraviolet absorbers, anti-inflammatory agents, in addition to Salixacea plant extracts and antioxidants. It is possible to contain general raw materials for medicines and cosmetics such as fragrances and antibacterial and antifungal agents, and physiologically active ingredients such as skin cell activating agents and whitening agents.

[0023]

EXAMPLES The features of the present invention will be described in detail with reference to Examples.

First, the preparation of a Salicaceae plant extract contained in the external preparation for skin according to the present invention will be described.

[Crown willow bark extract] To 200 g of fresh bark of Salix nigra collected in the spring was shredded, 1000 g of purified water was added, and the mixture was extracted at 25 ° C for 36 hours with stirring. The obtained extract was filtered and then concentrated under reduced pressure to obtain 150 g of willow bark extract.

[European porcupine leaf extract] 200 g of fresh leaves of European porcupine ( Populus tremula )
1000g of purified water is added to the shredded product,
Extract for 36 hours with stirring. The obtained extract was filtered and then concentrated under reduced pressure to obtain 120 g of a porcupine leaf extract.

[European willow bark extract] Dried European willow ( Salix alba L .; Salix aurea Salis
b.) 50g is crushed and 1000g of 50% by volume ethanol
And extract at room temperature for 24 hours. The obtained extract was filtered, concentrated under reduced pressure, and then freeze-dried to obtain 5 g of a willow bark extract.

[Weeping willow leaf extract] Fresh weeping willow ( Salix babylonica L.) shoots 10 g
Purified water (100 g) is added to and the mixture is stirred and extracted with a mixer for 10 minutes. The obtained extract was filtered, concentrated under reduced pressure, and lyophilized to obtain 1.2 g of weeping willow leaf extract.

The antioxidants used in the following examples of the present invention were those commercially available for pharmaceuticals or cosmetics.

Next, the formulations of the examples of the external preparation for skin according to the present invention will be shown.

Examples 1 to 8, Comparative Examples 1 to 5 Skin Cream (1) Beeswax 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 ( 4) Squalane 37.5 (5) Fatty acid glycerin 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20 E.O.) sorbitan monolaurate 2.0 (8) Propylene Glycol 5.0 (9) Methyl parahydroxybenzoate 0.1 (10) Salicaceae plant extract shown in Table 1 1.0 (11) Purified water Amount based on 100 (12) Table 1 Antioxidant shown: As described (13) Perfume 0.2 Manufacturing method: The oil phase components of (1) to (7) are mixed and dissolved to homogenize, and heated to 75 ° C. On the other hand, the water phase components (8) to (11) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the above aqueous phase component to carry out preliminary emulsification, and then uniformly emulsified with a homomixer. Then, cool it down at 50 ℃ (12),
Add (13) and mix.

[0032]

[Table 1]

Using Examples 1 to 8 and Comparative Examples 1 to 5, the effect of preventing the generation of wrinkles due to ultraviolet rays was evaluated. The evaluation of the wrinkle prevention effect was carried out by treating 5 hairless mice as one group, and applying an example and a comparative example to the back once a day for each group, and applying 1 J / cm ² / week of long wavelength ultraviolet light (UVA). Irradiation was carried out for 50 weeks, and the occurrence of wrinkles in hairless mice was observed, and scored according to the criteria shown in Table 2. At this time, a group to which only purified water was applied served as a control. The results are shown in Table 3 by calculating the average value of each group and the relationship with the number of UVA irradiation days.

[0034]

[Table 2]

[0035]

[Table 3]

As shown in Table 3, Salixae ( Salica
Ceae) Compared to Comparative Example 1 was not blended both plant extracts compared formulated alone Example 2 Comparative Example 5, or Salicaceae (Salicaceae) plant extracts and antioxidants, Salicaceae (Salicaceae In the examples of the present invention in which the plant extract and the antioxidant were used in combination, the generation of wrinkles was remarkably suppressed, and minute wrinkles were slightly generated after 50 weeks.

Next, a practical use test for 6 months was conducted on Examples 1 to 8 and Comparative Examples 1 to 5 of the present invention. As panelists, women in their 40's to 60's who have skin symptoms such as remarkable wrinkles or decreased elasticity, and women in their 20's to 50's who have remarkable skin irritation symptoms, each group 20 people And The use test was carried out by allowing each group to use each of the example and the comparative example blindly and observing the skin condition before the start of the use test and after the end of the use test. Each of the improvement states of wrinkles and skin elasticity was evaluated in three stages of “improvement”, “slight improvement” and “no change”, and the number of panelists who obtained each evaluation is shown in Table 4.
The degree of wrinkles was evaluated by taking photographs and replicas, and the skin elasticity was evaluated by measuring with a cute meter. Regarding skin roughness, the skin condition was scored according to the criteria shown in Table 5, and the average value of 20 persons was used to compare before use test start and after use test end.
It was shown to.

[0038]

[Table 4]

As shown in Table 4, in the groups used in the examples of the present invention, there were no panelists in which wrinkles and skin elasticity were not improved, and clear improvement was observed in 16 or more panelists. On the other hand, in the use groups of Comparative Examples 1 to 4, wrinkles and elasticity were tended to be improved, but the number of panelists in which clear improvement was recognized was 10 or less.

[0040]

[Table 5]

[0041]

[Table 6]

As shown in Table 6, in the groups used in the examples of the present invention, all the panelists showed an improvement tendency of rough skin, and most of the panelists were able to clearly see the sulcus and the cuticle. . On the other hand, in Comparative Examples 2 to 5 in which the various components were blended alone, the skin condition was improved as compared with Comparative Example 1 in which the various components were not blended, but the skin groove was flat and the cuticles were smooth. The shape remained unclear.

In Examples 1 to 8 of the present invention, no change in the preparation state such as precipitation, separation, aggregation, odor change or discoloration of the contained components was observed during the use test period. In addition, in each of the groups used in each Example, no panelists showed skin irritation reaction or skin sensitization reaction.

Example 9 Emulsion (1) Cetanol 1.0 (wt%) (2) Beeswax 0.5 (3) Vaseline 2.0 (4) Squalane 6.0 (5) Dimethylpolysiloxane 2.0 (6) d-δ-tocopherol 0.2 (7) polyoxyethylene (20E.O.) sorbitan 1.0 monostearate (8) glyceryl monostearate 1.0 (9) glycerin 4.0 ( 10) 1,3-Butylene glycol 4.0 (11) Methyl paraoxybenzoate 0.1 (12) Cryptomeria bark extract 0.5 (13) Purified water 62.6 (14) Carboxyvinyl polymer 10.0 (1) 0.0 wt% aqueous solution) (15) Potassium hydroxide (10.0 wt% aqueous solution) 1.0 (16) Ethanol 5.0 Production method: Mix the oil phase components of (1) to (8), heat and dissolve. To 75 ° C. On the other hand, the water phase components (9) to (13) are mixed and dissolved to reach 75 ° C. After the above oil phase was added to this and pre-emulsified, (14) was added and uniformly emulsified with a homomixer, then (15) was added to thicken and then cooled.
Add (16) at ℃ and mix.

[Example 10] Oil-in-water cream (1) Beeswax 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 27.5 (5) Glyceryl Fatty acid ester 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20E.O.) sorbitan 5.0 Monolaurate (8) Propylene glycol 5.0 (9) Paraoxy Methyl benzoate 0.1 (10) European porcupine leaf extract 1.0 (11) Purified water 36.2 (12) Birch extract 0.2 Process: Mix the oil phase components of (1) to (7), Melt to 75 ° C. On the other hand, mix and dissolve the water phase components (8) to (11),
Heat to 5 ° C. Next, the oil phase component is added to the aqueous phase component to pre-emulsify it, then homogenize with a homomixer, and after cooling, (12) is added and mixed at 40 ° C.

[Example 11] Oil-in-water cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 27.5 (5) Glyceryl Fatty acid ester 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20E.O.) sorbitan 5.0 Monolaurate (8) Propylene glycol 5.0 (9) Paraoxy Methyl benzoate 0.1 (10) European willow bark extract 0.3 (11) Purified water 37.0 (12) Rutin glucoside 0.1 Manufacturing method: Mix and dissolve the oil phase components (1) to (7) To 75 ° C. Meanwhile, the water phase components (9) to (11) are mixed and dissolved, and 75
Heat to ℃. Next, the oil phase component is added to the aqueous phase component to pre-emulsify it, then homogenize with a homomixer, and after cooling, (12) is added and mixed at 40 ° C.

[Example 12] Gel agent (1) Dipropylene glycol 10.0 (wt%) (2) Carboxyvinyl polymer 0.5 (3) Methyl paraoxybenzoate 0.1 (4) Weeping willow leaf extract 0 .2 (5) Oolong tea extract 0.3 (6) Purified water 87.9 (7) Potassium hydroxide (10.0 wt% aqueous solution) 1.0 Manufacturing method: (6) with (1) to (5) After uniformly dissolving, (7) is added to increase the viscosity.

[Example 13] Oil-in-water emulsion type ointment (1) White petrolatum 25.0 (% by weight) (2) Stearyl alcohol 25.0 (3) Glycerin 12.0 (4) Sodium lauryl sulfate 1.0 (5) Methyl paraoxybenzoate 0.1 (6) Purified water 35.4 (7) Willow bark extract 0.5 (8) Hamamelis extract 1.0 Process: Oil phase components of (1) to (4) Are mixed and heated to dissolve uniformly, and the temperature is adjusted to 75 ° C. On the other hand, mix the water phase components of (5) and (6),
Heat to 75 ° C. The oil phase component was gradually added to this water phase component while stirring to emulsify and cool the mixture.
Add (7) and (8) at ℃ and mix.

[Example 14] Liposome agent (1) Glycerin 2.0 (wt%) (2) 1,3-butylene glycol 3.0 (3) Polyoxyethylene (25E.O.) oleyl ether 0.2 (4) Ethanol 10.0 (5) Methyl paraoxybenzoate 0.1 (6) Purified water 79.7 (7) European porcupine leaf extract, birch 5.0 Extract-encapsulated liposomes Preparation method: (4) ), Add to (6) together with (1) to (3), mix uniformly, and add (7) to this and disperse. The (7) European porcupine leaf extract and birch extract-containing liposomes contained 1.0 (w / v)% European porcupine leaf extract and 2.0 (w / v)% birch extract. 80 g of soybean lecithin was added to 100 ml of a volume% aqueous ethanol solution, suspended at 55 ° C., and then sonicated to prepare liposomes, which were recovered by centrifugation.

[Example 15] Water-in-oil type emollient cream (1) Liquid paraffin 30.0 (% by weight) (2) Microcrystalline wax 2.0 (3) Vaseline 5.0 (4) Diglyceryl dioleic acid Ester 5.0 (5) L-Glutamate sodium 1.6 (6) L-serine 0.4 (7) Propylene glycol 3.0 (8) Methyl paraoxybenzoate 0.1 (9) European willow bark extract 0 .5 (10) Purified water 52.1 (11) β-carotene 0.2 (12) Perfume 0.1 Production method: (5) and (6) were dissolved in a part of (10) to 50 ° C., Gradually add to (4) previously heated to 50 ° C. with stirring. These are mixed in advance and uniformly dispersed in (1) to (3) which are dissolved by heating at 70 ° C. Add (7) to (9) to (1
Add to the rest of 0), heat to 70 ° C., add with stirring, and emulsify with a homomixer. After cooling, (11) and (12) are added and mixed at 40 ° C.

[Example 16] Makeup base cream (1) Stearic acid 12.00 (% by weight) (2) Cetanol 2.00 (3) Glyceryl tri-2-ethylhexanoate 2.50 (4) Self-emulsification Glyceryl monostearic acid 2.00 Ester (5) Propylene glycol 10.00 (6) Weeping willow leaf extract 0.02 (7) Methyl paraoxybenzoate 0.10 (8) Birch extract 0.05 (9) Water Potassium oxide 0.30 (10) Purified water 68.43 (11) Titanium oxide 2.00 (12) Red iron oxide 0.40 (13) Yellow iron oxide 0.10 (14) Perfume 0.10 Manufacturing method: (1) to Mix and dissolve the oil phase components of (4) to 75 ° C. On the other hand, the water phase components (5) to (10) are mixed, heated and dissolved, and the pigment components (11) to (13) are added thereto, and the mixture is uniformly dispersed with a homomixer to 75 ° C. Next, the oil phase component is added to the aqueous phase component, and the mixture is uniformly emulsified with a homomixer. After cooling, (14) is added and mixed at 40 ° C.

Example 17 Milky liquid foundation (1) Stearic acid 2.00 (% by weight) (2) Squalane 5.00 (3) Octyldodecyl myristate 5.00 (4) Cetanol 1.00 (5) Decaglyceryl monoisopalmitic acid ester 9.00 (6) 1,3-butyleneglycol 6.00 (7) Methyl paraoxybenzoate 0.10 (8) Potassium hydroxide 0.08 (9) Purified water 51.57 (10) Titanium oxide 9.00 (11) Talc 7.40 (12) Red iron oxide 0.50 (13) Yellow iron oxide 1.10 (14) Black iron oxide 0.10 (15) Black willow bark extract 1.00 (16) Hamamelis extract 1.00 (17) Perfume 0.15 Production method: The oil phase components (1) to (5) are mixed and dissolved to 75 ° C. On the other hand, the water phase components (6) to (9) are mixed, heated and dissolved, and the pigment components (10) to (14) are added thereto, and the mixture is uniformly dispersed with a homomixer to 75 ° C. Next, the oil phase component is added to the aqueous phase component, and the mixture is uniformly emulsified with a homomixer. After cooling, (15) to (17) are added and mixed at 40 ° C.

Example 18 Hand Cream (1) Cetanol 4.00 (wt%) (2) Vaseline 2.00 (3) Liquid Paraffin 10.00 (4) Glyceryl Monostearate 1.50 (5) Polyoxyethylene (60 E.O.) glyceryl 2.50 Isostearate (6) Tocopherol acetate 0.25 (7) Glycerin 20.00 (8) Methyl paraoxybenzoate 0.10 (9) European porcupine leaf extract 0 .50 (10) Rutin glucoside 0.02 (11) Purified water 59.13 Production method: The oil phase components (1) to (6) are mixed and dissolved to 75 ° C. On the other hand, the water phase components (7) to (11) are mixed and dissolved, and
Set to 5 ° C. Next, the oil phase component is added to the aqueous phase component, and the mixture is uniformly emulsified with a homomixer and cooled.

[Example 19] Pack (1) Purified water 69.0 (% by weight) (2) Polyvinyl alcohol 12.5 (3) Ethanol 10.0 (4) Glycerin 5.0 (5) Polyethylene glycol (average) Molecular weight 1540) 3.0 (6) Willow bark extract 0.3 (7) Rutin 0.2 Production method: The components (2) to (7) are sequentially added to (1),
Mix, dissolve and homogenize.

[0055]   Example 20 Hair Nick (1) Ethanol 50.0 (wt%) (2) Purified water 48.0 (3) Tocopherol acetate 0.5 (4) Weeping willow leaf extract 1.5 Manufacturing method: Components (1) to (4) are mixed and uniformly dissolved.

[Example 21] Hair shampoo (1) Sodium alkyl ether sulfate 18.0 (% by weight) (2) Coconut oil fatty acid diethanolamide 2.0 (3) Propylene glycol 2.0 (4) Black willow bark extract 0.5 (5) Rutin 0.1 (6) Purified water 77.4 Production method: The components (1) to (5) are sequentially added to (6),
Make it uniform.

Example 22 Hair rinse (1) Cetanol 3.0 (wt%) (2) Stearyl trimethyl ammonium chloride 0.7 (3) Glycerin 3.0 (4) N-cocoyl-L-arginine ethyl ester -DL-pyrrolidone carboxylic acid salt 0.1 (5) Rutin glucoside 0.1 (6) European porcupine leaf extract 3.0 (7) Purified water 90.1 Production method: (1) to (6) components in order Add to (7),
Mix.

[Example 23] Liquid body shampoo (1) N-lauroyl-L-glutamic acid 20.0 (% by weight) Triethanolamine (30.0% by weight aqueous solution) (2) N-lauroylmethyl taurine sodium 10. 0 (30.0 wt% aqueous solution) (3) triethanolamine laurate 10.0 (4) triethanolamine myristate 10.0 (5) lauroyl imidazolinium betaine 5.0 (6) lauroyl diethanolamide 5. 0 (7) Propylene glycol 7.0 (8) Weeping willow leaf extract 1.0 (9) Birch extract 0.5 (10) Purified water 31.5 Process: The components of (1) to (9) are sequentially added. Add to (10) and mix.

Example 24 Face Wash Foam (1) Myristic Acid 18.0 (wt%) (2) Palmitic Acid 3.0 (3) Stearic Acid 7.0 (4) Mixed Fatty Acid Triglyceride 0.1 (5) Stearyl glycyrrhetinate 0.1 (6) Self-emulsifying glyceryl monostearate 3.0 (7) Purified water 37.0 (8) Glycerin 17.0 (9) Potassium hydroxide 7.8 (10) Diglycerin 3. 0 (11) 1,3-butylene glycol 1.0 (12) N-stearolyl-L-glutamate disodium 1.0 (13) Methyl paraoxybenzoate 0.1 (14) Weeping willow leaf extract 1.0 (15 ) Oolong tea extract 0.9 Manufacturing method: The oil phase components of (1) to (6) are mixed and dissolved by heating to 70 ° C. The aqueous phase components (7) to (15) are mixed, dissolved and heated to 70 ° C. The above oil phase is gradually added to this aqueous phase component for saponification, and then cooled while mixing.

Regarding Example 1 to Example 22, 2
No change in condition was observed when stored at 5 ° C for 6 months, and no problem skin irritation reaction was observed in a 48-hour back occlusion patch test conducted by 30 male panelists.

[0061]

As described in detail above, according to the present invention, it is possible to prevent the skin from becoming rough and aging, and to prevent the generation of lipid peroxide due to the generation of active oxygen in the skin, and the inflammation and rough skin. Alternatively, a skin external preparation having an improving effect could be obtained.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 TU W 7/021 7/021 7/06 7/06 7/075 7 / 075 7/08 7/08 7/48 7/48 7/50 7/50 35/78 35/78 C 45/00 45/00 A61P 17/00 A61P 17/00 43/00 121 43/00 121 F Terms (reference) 4C083 AA111 AA112 AA122 AB032 AB232 AB242 AB432 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC352 AC422 AC442 AC482 AC582 AC642 AC662 AC692 AC712 AC782 AC792 AD092 AD112 AD152 AD392 AD412 AD512 AD622 AD66 BB47 CC02 CC31 CC33 CC08 CC38 DD45 4C084 AA19 MA02 MA63 NA05 ZA89 ZC75 4C088 AB12 AC06 CA05 MA63 NA05 ZA89 ZC75

Claims (5)

[Claims] 1. A skin external preparation comprising a Salicaceae plant extract and one or more antioxidants. Wherein Salicaceae (Salicaceae) extracts of plants is a water extract of Salicaceae (Salicaceae) plants, skin external preparation according to claim 1. 3. Salicaceae (Salicaceae) extracts of plants is an extract from the bark of Salicaceae (Salicaceae) plants, skin external preparation according to claim 1 or claim 2. 4. The external preparation for skin according to claim 1, wherein the extract of Salicaceae plant is Salix nigra L. extract. 5. Antioxidants include carotenoids, flavonoids, tannins, gallic acid and its salts, and esters, tocopherol and its derivatives, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole. The external preparation for skin according to claim 1, which is one kind or two or more kinds selected from the group consisting of: