JP2003221323A - Capsule - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prepare a gelatin-free coating film for capsules showing an excel lent strength, flexibility and heat-sealing properties, since the use of gelatin is disliked by vegetarians due to its animal-derived nature and is also undesir able from the viewpoint of infection with diseases such as BSE, although conven tional coating films for capsules have been generally prepared from gelatin, plasticizers such as glycerol, sorbitol, or the like, antiseptics and sweeteners. <P>SOLUTION: The composition of coating components of capsules contains an enzymatically decomposed product of hydroxypropylated starch containing 3-10% hydroxypropyl group. Here, a 25% aqueous solution of the starch has a viscosity measured at 30°C using a BM viscometer at 30 rpm of 10-300 cps. <P>COPYRIGHT: (C)2003,JPO

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a capsule. More particularly, it relates to a capsule coating. 2. Description of the Related Art Conventionally, capsule films are generally produced from gelatin, a plasticizer such as glycerin or sorbitol, a preservative and a sweetener. JP-A-5-5065 discloses that derivative starch such as hydroxypropylated starch can be used in the composition of the film. JP 200
No. 0-35534 proposes the use of pregelatinized oxidized wheat starch as a starch modified to have gelatinous properties. WO01 / 03677A
1, iota carrageenan and hydroxypropylated tapioca starch, hydroxypropylated corn starch,
Compositions of capsule coatings comprising at least one starch selected from the group of acid-treated hydroxypropylated corn starch and the like have been proposed. [0003] Gelatin is hated by vegetarians because it is an animal substance. Further, it is not preferable to use it from the viewpoint of infection of diseases such as mad cow disease. A derivative starch has been proposed instead, but lacks flexibility. In addition, there is a problem that heat sealing cannot be performed. As a result of repeated studies, the present inventors have determined that the viscosity of a 25% aqueous solution is 10 to 300 cps, preferably 10 to 300 cps, measured at 30 ° C. with a BM viscometer at 30 rpm. By using an enzymatically decomposed product of hydroxypropylated starch which is 200 cps and has 3 to 10%, preferably 4 to 8% of hydroxypropoxyl groups,
Even without gelatin, it was found that a film excellent in flexibility and heat sealability could be obtained.
The present invention has been completed. DETAILED DESCRIPTION OF THE INVENTION Enzymatic degradation products of hydroxypropylated starch which can be used in the present invention include natural starch such as corn starch, high amylose corn starch, waxy corn starch, potato starch, tapioca starch, wheat starch, rice starch and the like. And derivatives thereof, such as acetylation, succination, octenyl succination, phosphorylation, carboxymethylation, and phosphoric acid cross-linking, can be obtained by subjecting them to hydroxypropylation by a conventional method and subjecting them to enzymatic decomposition. For example, propylene oxide is added to an aqueous suspension of starch, caustic soda is added as a catalyst, the mixture is stirred and reacted, neutralized, filtered and dried. A hydroxypropoxyl group having 3 to 10%, preferably 4 to 8% can be used. Below this, the starch degradation product ages, becomes cloudy, and becomes inflexible and brittle. Even above this, the flexibility of the film is not further improved, and the production cost of the hydroxypropylated starch increases. In order to improve the flexibility of the film and the heat sealing property, the hydroxypropylated starch is gelatinized by heating in water and decomposed by an enzyme such as α-amylase.
Inactivate, decolorize, purify and dry the enzyme. At this time, the viscosity of the 25% aqueous solution is measured at 30 ° C. with a BM viscometer at 30 rpm, and is 10 to 300 cps, preferably 10 to 200 cps.
ps can be used. If it is 300 cps or more, the heat sealing property deteriorates. In addition, when the viscosity is high, when the concentration of the aqueous solution is increased, the fluidity is deteriorated. 10c
Below ps, the film formability is poor. Enzyme decomposed products of starch have a broader molecular weight distribution if they have the same viscosity as compared with acid decomposed products. It is considered that the heat sealing property is improved. In order to further impart flexibility to the hydrolyzate of hydroxypropylated starch, glycerin as a plasticizer,
Propylene glycol, sorbitol, maltitol,
Polyhydric alcohols such as xylitol and saccharides such as glucose, fructose, sugar, reduced starch syrup, etc.
It is preferable to mix by 50%. Also, natural starch, derivative starch such as hydroxypropylated or acetylated, carrageenan, agar, locust bean gum, guar gum, glucomannan, gum arabic, soy polysaccharide, pectin,
Polysaccharides such as sodium alginate may be mixed to increase the strength of the film. The method for preparing a capsule film in the present invention can be carried out in the same manner as a conventional method for preparing a film. For example, it can be manufactured using a manufacturing method such as a rotary type or a flat plate type. Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples. <Examples 1 to 4, Comparative Examples 1 and 2> Hydroxypropylated potato starch and potato starch having different amounts of hydroxypropoxyl groups were enzymatically decomposed by a conventional method to obtain 25%
The viscosity of the aqueous solution was measured at 30 ° C. with a BM type viscometer at 30 rpm to produce a 150 cps starch enzyme degradation product. 100 g of the enzyme digest of starch, 30 g of glycerin and 120 g of ion-exchanged water were mixed, dissolved by heating, defoamed under reduced pressure, cast on a polyethylene terephthalate film, dried with hot air, and dried with hot water at a moisture content of 12%. A 6 mm sheet was obtained. A test piece of 1 cm × 3 cm was prepared, and the tensile speed was 20 mm / m using Tensilon Model UTM-III-100 (a universal tensile tester manufactured by Toyo Baldwin Co., Ltd.).
In, the strength and elongation were measured. The sheet prepared by the same operation using gelatin instead of the starch hydrolyzate had a strength of 220 gf / mm 2 and an elongation of 420%. In addition, two of these test pieces were stacked and SEALER 30
6 (Nikko Co., Ltd., sealer), heat-sealed at a scale of 5, and then peeled off by hand to test the heat-sealing performance. The results are shown in Table 1. The HP group in the table is
Represents a hydroxypropoxyl group, and the heat sealability is
It is an evaluation in comparison with gelatin. The potato starch of Comparative Example 2 has 0% of the HP group. [Table 1] The sheet of Comparative Example 2 became cloudy one day after the preparation. It is clear that the sheet of the present invention can be used as a capsule film in both strength and elongation, and the heat sealing performance was also good. <Examples 5 and 6, Comparative Examples 4 and 5> Hydroxypropyl potato starch having a hydroxypropoxyl group content of 7% was decomposed by an α-amylase to a predetermined viscosity by a conventional method. This starch enzyme hydrolyzate was subjected to the same operation as in Example 1 to obtain a sheet having a moisture content of 12% and a thickness of 0.6 mm. The strength, elongation, and heat sealability of this sheet were measured in the same manner as in Example 1. The results are shown in Table 2.
In addition, the viscosity in a table | surface is a density | concentration of 25%, 30 degreeC, and a BM type viscometer 30 rpm viscosity. [Table 2] It is clear that the sheet of the present invention can be used as a capsule film in both strength and elongation, and the heat sealing performance was also good. Example 7 60 g of the hydroxypropylated starch hydrolyzate of Example 2, 40 g of sorbitol and 90 g of ion-exchanged water were mixed and dissolved by heating. The same operation as in Example 1 was carried out to obtain a water content of 12% and a thickness of 0 g. A sheet of 0.5 mm was obtained.
The strength of this sheet is 190 gf / mm 2 and the elongation is 2
It was 40%. It was clear that both the strength and the elongation could be used as a capsule film, and the heat sealing performance was also good. Example 8 30 g of the hydroxypropylated starch hydrolyzate of Example 2, 30 g of hydroxypropylated potato starch having 7% hydroxypropyl group and sorbitol 4
0 g and 90 g of ion-exchanged water were mixed and dissolved by heating, and the same operation as in Example 1 was performed to obtain a sheet having a water content of 12% and a thickness of 0.6 mm. The strength of this sheet is 200gf / mm
2. The elongation was 340%. It is clear that both strength and elongation can be used as a capsule film. The heat sealing performance was also good. Example 9 60 g of the hydroxypropylated starch hydrolyzate of Example 2 and NEWGELIN KC-20
4 g of OSS (carrageenan, manufactured by Chuo Kasei Co., Ltd.), 40 g of sorbitol, and 90 g of ion-exchanged water were mixed and dissolved by heating. . The strength of this sheet is 240
gf / mm 2 , elongation was 200%. It is clear that both strength and elongation can be used as a capsule film. The heat sealing performance was also good. Comparative Example 6 The viscosity of a 25% aqueous solution containing 7% of hydroxypropoxyl group was measured at 30 ° C. using a BM type viscometer at 30 rpm instead of the enzymatically decomposed product of the hydroxypropylated starch in Example 2. The same operation as in Example 1 was carried out using an acid hydrolyzate of hydroxypropylated potato starch of 200 cps to obtain a sheet having a water content of 12% and a thickness of 0.6 mm. The strength, elongation, and heat sheet properties of this sheet were measured in the same manner as in Example 1. Strength is 440gf / mm
2. The elongation is 150% and the film formability is good, but lacks flexibility and cannot be used as a capsule. The heat sealability was poor, and the sheets did not adhere to each other. According to the present invention, as described above, it is possible to produce a capsule film which does not contain gelatin and which is excellent in strength, flexibility and heat sealability.

Continuation of front page    (72) Inventor Hidemi Ohno             3-29 Mitsuya Kita 3-chome, Yodogawa-ku, Osaka-shi, Osaka             issue (72) Inventor Nobumasa Tanaka             3-29 Mitsuya Kita 3-chome, Yodogawa-ku, Osaka-shi, Osaka             issue F term (reference) 4C076 AA53 AA58 EE38 FF70

Claims (1)

Claims: 1. The viscosity of a 25% aqueous solution is BM at 30 ° C.
It is 10 to 300 cps measured by a viscometer at 30 rpm,
A capsule film comprising an enzymatically decomposed product of hydroxypropylated starch having a hydroxypropoxyl group content of 3 to 10%.