JP2003250556A - 糖代謝異常疾患マーカーおよびその利用 - Google Patents

Abstract

(57)【要約】 （修正有） 【課題】糖代謝異常疾患を反映する疾患マーカー、該疾
患マーカーを利用した糖代謝異常疾患の検出法、該疾患
の改善に有用な薬物のスクリーニング法を提供する。 【解決手段】特定の塩基配列において、連続する少なく
とも15塩基を有するポリヌクレオチドおよび／または該
ポリヌクレオチドに相補的なポリヌクレオチドを糖代謝
異常疾患の疾患マーカーとする。

Description

【発明の詳細な説明】

【０００１】

【発明の属する技術分野】本発明は、糖代謝異常疾患の
診断に有用な疾患マーカーに関する。より詳細には、本
発明は糖代謝異常疾患、例えば糖尿病、特に2型糖尿
病、高脂血症、肥満症などの疾患の遺伝子診断におい
て、プライマーまたは検出プローブとして有効な疾患マ
ーカーに関する。また本発明は、かかる疾患マーカーを
利用した糖代謝異常疾患の検出方法(診断方法)に関す
る。

【０００２】さらに本発明は、上記疾患マーカーを利用
して、糖代謝異常疾患の予防薬、改善薬または治療薬と
して有効な物質をスクリーニングする方法、並びに該方
法で調製される上記物質を有効成分とする糖代謝異常疾
患の予防薬、改善薬または治療薬に関する。

【０００３】

【従来の技術】近年、食生活の西洋化、社会的ストレス
の増加などにより、例えば肥満、それに付随する生活習
慣病などの糖代謝異常疾患、特に2型糖尿病に罹患する
患者が著しく増加している。

【０００４】現在、この2型糖尿病の治療では、まず運
動療法および食事療法によって摂食量および体重が管理
され、これらの療法によっても体重コントロールなどが
不十分な場合には、更に薬物療法が行われている。この
薬物療法には、特に血糖値を十分に低下させることがで
きかつ安全な治療薬が望まれている。

【０００５】一方、筋肉および脂肪は、インスリンなど
の糖代謝調節因子により制御されており、全身の糖代謝
に重要な役割を演じている。特に、ヒトでは、筋肉の全
身に対する割合は大きく、従って、筋肉の糖代謝の変化
(異常)が血糖値変化に与える影響は非常に大きいと考え
られる。このことは、2型糖尿病患者において筋肉のイ
ンスリン抵抗性(インスリンの感受性が低下している状
態)が観察されることからも明らかである。このように
筋肉の状態変化は、糖尿病などの糖代謝異常疾患の病態
に大きく影響していると考えられる。

【０００６】肝臓も糖代謝、血糖調節などに重要な影響
を与える。このことは、通常インスリンの作用により抑
制されている肝糖新生、肝糖放出などが、糖尿病患者で
は亢進した状態になっていることからも知ることができ
る。

【０００７】このような観点から、筋肉におけるインス
リン抵抗性の解除もしくは筋肉および肝臓における糖代
謝の改善などを行うことができる薬剤は、糖尿病の病態
改善に大きく貢献すると考えられる。

【０００８】しかしながら、このような作用機序面から
開発され且つ安全性などの面で問題なく使用できる薬剤
は、現在のところ上市されておらず、このような薬剤の
開発が望まれている。

【０００９】また、現在、糖尿病などの糖代謝異常疾患
の診断は、被験者の個人差を考慮することなく、総じて
例えば経口糖負荷試験などの安価な健診により行われて
いる。

【００１０】しかるに、最近の医療現場では、糖代謝異
常疾患に限らず、各種の疾患のそれぞれについて、個々
の患者毎の症状の診断、該症状に合わせた的確な治療法
の選択が望まれるようになってきている。高齢化社会で
のQOL(Quality of life)向上の必要性が認識されてきた
近年では、特に、万人に共通した診断および治療ではな
く、個々の患者毎の診断(症状の診断)および治療が施さ
れることが強く求められている。このような所謂テイラ
ーメイド診断および治療を行うためには、個々の疾患に
ついて患者の症状やその原因(遺伝的背景)を的確に反映
する疾患マーカーが有用であり、その探索並びに開発を
目指した研究が精力的に行われているのが現状である。

【００１１】

【発明が解決しようとする課題】本発明は、糖代謝異常
疾患の診断、治療などに有用な疾患マーカーを提供する
ことを目的とする。より詳細には、本発明は糖代謝異常
疾患を正確に反映する疾患マーカーを提供することを目
的とする。さらに本発明は該疾患マーカーを利用した糖
代謝異常疾患の検出方法(遺伝子診断方法)、該疾患の予
防、改善または治療に有用な薬物をスクリーニングする
方法、並びに該疾患の予防、改善または治療に有用な薬
物を提供することを目的とする。

【００１２】

【課題を解決するための手段】本発明者は、上記課題を
解決するために、まず2型糖尿病患者の筋肉および肝臓
に観察されるインスリン抵抗性、即ちインスリンに対す
る感受性が低下している状態に着目し、この病態に関連
して患者の筋肉および肝臓でその発現が変動する遺伝子
を探索した。

【００１３】その結果、配列番号：1、2、3、4、5、6、
7、8、9、10、11、12、13、14、15、16、17、18、19、2
0、21、22、23、24、25、26、27、28、29、30、31、3
2、33、34、35、36、37、38、39、40、41、42、43、4
4、45、46、47、48、49、50、51、52、53、54、55、5
6、57、58、59、60、61、62、63、64、65、66、67、6
8、69、70、71、72、73、74、75、76、77、78、79、8
0、81、82、83、84、85、86、87、88、89、90、91、9
2、93、94、95、96、97、98、99、100、101、102、10
3、104、105、106、107、108、109、110、111、112、11
3、114、115、116、117、118、119、120、121、122、12
3、124、125、126、127、128、129、130、131、132、13
3、134、135、136、137、138、139、140、141、142、14
3、144、145、146、147、148、149、150、151、152、15
3、154、155、156、157、158、159、160、161、162、16
3、164、165、166、167、168、169、170、171、172、17
3、174、175、176、177、178、179、180、181、182、18
3、184、185、186、187、188、189、190、191、192、19
3、194、195、196、197、198、199、200、201、202、20
3、204、205、206、207、208、209、210、211、212、21
3、214、215、216、217、218、219、220、221、222、22
3、224、225、226、227、228、229、230、231、232、23
3、234、235、236、237、238、239、240、241、242、24
3、244、245、246、247、248、249、250、251、252、25
3、254、255、256、257、258、259および260で示される
いずれかの塩基配列(以下、本明細書において「配列番
号：1-260」ともいう)を有する遺伝子が、2型糖尿病患
者の肝臓において特異的に検出されるかもしくはその検
出量が正常者に比して有意に増大されることを見出し
た。

【００１４】また、本発明者は、配列番号：314、315、
316、317、318、319、320、321、322、323、324、325、
326、327、328、329、330、331、332、333、334、335、
336、337、338、339、340、341、342、343、344、345、
346、347、348、349、350、351、352、353、354、355、
356、357、358、359、360および361(以下、本明細書に
おいて「配列番号：314-361」ともいう)で示されるいず
れかの塩基配列を有する遺伝子が、2型糖尿病患者の筋
肉において特異的に検出されるかもしくはその検出量が
正常者に比して有意に増大されることを見出した。

【００１５】これらのことから、本発明者は、かかる遺
伝子が糖代謝異常疾患の疾患マーカーとなり得るとの確
信を得た。本発明はかかる知見を基礎として完成された
ものである。

【００１６】即ち、本発明の要旨は、下記項1-項25とし
て掲げる点にある。

【００１７】項1． 配列番号：1、2、3、4、5、6、7、
8、9、10、11、12、13、14、15、16、17、18、19、20、
21、22、23、24、25、26、27、28、29、30、31、32、3
3、34、35、36、37、38、39、40、41、42、43、44、4
5、46、47、48、49、50、51、52、53、54、55、56、5
7、58、59、60、61、62、63、64、65、66、67、68、6
9、70、71、72、73、74、75、76、77、78、79、80、8
1、82、83、84、85、86、87、88、89、90、91、92、9
3、94、95、96、97、98、99、100、101、102、103、10
4、105、106、107、108、109、110、111、112、113、11
4、115、116、117、118、119、120、121、122、123、12
4、125、126、127、128、129、130、131、132、133、13
4、135、136、137、138、139、140、141、142、143、14
4、145、146、147、148、149、150、151、152、153、15
4、155、156、157、158、159、160、161、162、163、16
4、165、166、167、168、169、170、171、172、173、17
4、175、176、177、178、179、180、181、182、183、18
4、185、186、187、188、189、190、191、192、193、19
4、195、196、197、198、199、200、201、202、203、20
4、205、206、207、208、209、210、211、212、213、21
4、215、216、217、218、219、220、221、222、223、22
4、225、226、227、228、229、230、231、232、233、23
4、235、236、237、238、239、240、241、242、243、24
4、245、246、247、248、249、250、251、252、253、25
4、255、256、257、258、259、260、314、315、316、31
7、318、319、320、321、322、323、324、325、326、32
7、328、329、330、331、332、333、334、335、336、33
7、338、339、340、341、342、343、344、345、346、34
7、348、349、350、351、352、353、354、355、356、35
7、358、359、360および361(以下、本明細書において
「配列番号：1-260, 314-361」ともいう)で示されるい
ずれかの塩基配列において、連続する少なくとも15塩基
を有するポリヌクレオチドおよび／または該ポリヌクレ
オチドに相補的なポリヌクレオチドである糖代謝異常疾
患の疾患マーカー。

【００１８】項2. 糖代謝異常疾患の検出においてプロ
ーブまたはプライマーとして使用される項1に記載の疾
患マーカー。

【００１９】項3. 肝臓における疾患マーカーであっ
て、配列番号：1-260で示されるいずれかの塩基配列に
基づく疾患マーカーである項1または2に記載の疾患マー
カー。

【００２０】項4. 筋肉における疾患マーカーであっ
て、配列番号：314-361で示されるいずれかの塩基配列
に基づく疾患マーカーである項1または2に記載の疾患マ
ーカー。

【００２１】項5. 下記の工程(a)、(b)および(c)を含
む糖代謝異常疾患の検出方法： (a) 被験者の生体試料から調製されたRNAまたは該RNAか
ら転写された相補的ポリヌクレオチドと項1-4のいずれ
かに記載の疾患マーカーとを結合させる工程、(b) 該疾
患マーカーに結合した生体試料由来のRNAまたは該RNAか
ら転写された相補的ポリヌクレオチドを、上記疾患マー
カーを指標として測定する工程、(c)上記(b)の測定結果
に基づいて、糖代謝異常疾患の罹患を判断する工程。

【００２２】項6． 糖代謝異常疾患の罹患を判断する
工程が、被験者について得られる測定結果を正常者につ
いて得られる測定結果と対比して、疾患マーカーへの結
合量が増大していることを指標として判断するものであ
る項5に記載の糖代謝異常疾患の検出方法。

【００２３】項7. 生体試料が肝臓由来の組織または細
胞であり且つ疾患マーカーが項3に記載のものである項5
または項6に記載の方法。

【００２４】項8. 生体試料が筋肉由来の組織または細
胞であり且つ疾患マーカーが項4に記載のものである項5
または項6に記載の方法。

【００２５】項9. 配列番号：261、262、263、264、26
5、266、267、268、269、270、271、272、273、274、27
5、276、277、278、279、280、281、282、283、284、28
5、286、287、288、289、290、291、292、293、294、29
5、296、297、298、299、300、301、302、303、304、30
5、306、307、308、309、310、311、312、313、362、36
3、364および365(以下、本明細書において「配列番号：
261-313, 362-365」ともいう)で示されるいずれかのア
ミノ酸配列を有する蛋白質を認識する抗体である糖代謝
異常疾患の疾患マーカー。

【００２６】項10. 糖代謝異常疾患の検出においてプ
ローブとして使用される項9に記載の疾患マーカー。

【００２７】項11. 肝臓における疾患マーカーであっ
て、配列番号：261-313で示されるいずれかのアミノ酸
配列に基づく疾患マーカーである項9または項10に記載
の疾患マーカー。

【００２８】項12. 筋肉における疾患マーカーであっ
て、配列番号：362-365で示されるいずれかのアミノ酸
配列に基づく疾患マーカーである項9または項10に記載
の疾患マーカー。

【００２９】項13. 下記の工程(a)、(b)および(c)を含
む糖代謝異常疾患の検出方法： (a) 被験者の生体試料から調製された蛋白質と項9-12の
いずれかに記載の疾患マーカーとを結合させる工程、
(b) 該疾患マーカーに結合した生体試料由来の蛋白質ま
たはその部分ペプチドを、上記疾患マーカーを指標とし
て測定する工程、(c) 上記(b)の測定結果に基づいて、
糖代謝異常疾患の罹患を判断する工程。

【００３０】項14. 糖代謝異常疾患の罹患を判断する
工程が、被験者について得られる測定結果を正常者につ
いて得られる測定結果と対比して、疾患マーカーへの結
合量が増大していることを指標として判断するものであ
る項13に記載の糖代謝異常疾患の検出方法。

【００３１】項15. 生体試料が肝臓由来の組織または
細胞であり且つ疾患マーカーが項11に記載のものである
項13または項14に記載の方法。

【００３２】項16. 生体試料が筋肉由来の組織または
細胞であり且つ疾患マーカーが項12に記載のものである
項13または項14に記載の方法。

【００３３】項17. 下記の工程(a)、(b)および(c)を含
む配列番号：1-260, 314-361で示されるいずれかの塩基
配列を有する遺伝子の発現を抑制する物質のスクリーニ
ング方法： (a) 被験物質と配列番号：1-260,314-361で示されるい
ずれかの塩基配列を有する遺伝子またはそのホモログを
発現可能な細胞とを接触させる工程、(b) 被験物質を接
触させた細胞における上記遺伝子またはそのホモログの
発現量を測定し、該発現量を被験物質を接触させない対
照細胞における同一遺伝子またはそのホモログの発現量
と比較する工程、(c) 上記(b)の比較結果に基づいて、
上記遺伝子またはそのホモログの発現量を抑制する被験
物質を選択する工程。

【００３４】項18. 糖代謝異常疾患の予防、改善また
は治療剤の有効成分を探索するための方法である項17に
記載のスクリーニング方法。

【００３５】項19. 下記の工程(a)、(b)および(c)を含
む配列番号：261-313,362-365で示されるいずれかのア
ミノ酸配列を有する蛋白質の発現量を減少させる物質の
スクリーニング方法： (a)被験物質と配列番号：261-313,362-365で示されるい
ずれかのアミノ酸配列を有する蛋白質またはそのホモロ
グを発現可能な細胞または該細胞から調製した細胞画分
とを接触させる工程、(b)被験物質を接触させた細胞ま
たは細胞画分における配列番号：261-313,362-365で示
されるいずれかのアミノ酸配列を有する蛋白質またはそ
のホモログの発現量を測定し、該発現量を被験物質を接
触させない対照細胞もしくは細胞画分における上記配列
番号：261-313,362-365で示されるいずれかのアミノ酸
配列を有する蛋白質またはそのホモログの発現量と比較
する工程、(c)上記(b)の比較結果に基づいて、配列番
号：261-313,362-365で示されるいずれかのアミノ酸配
列を有する蛋白質またはそのホモログの発現量を減少さ
せる被験物質を選択する工程。

【００３６】項20. 下記の工程(a)、(b)および(c)を含
む配列番号：261-313,362-365で示されるいずれかのア
ミノ酸配列を有する蛋白質の機能または活性を抑制する
物質のスクリーニング方法： (a)被験物質と配列番号：261-313,362-365で示されるい
ずれかのアミノ酸配列を有する蛋白質またはそのホモロ
グを含む水溶液、細胞または該細胞から調製した細胞画
分とを接触させる工程、(b)被験物質を接触させた水溶
液、細胞または細胞画分における配列番号：261-313,36
2-365で示されるいずれかのアミノ酸配列を有する蛋白
質またはそのホモログの機能または活性を測定し、該機
能または活性を被験物質を接触させない対照水溶液また
は対照細胞もしくは細胞画分における上記配列番号：26
1-313,362-365で示されるいずれかのアミノ酸配列を有
する蛋白質またはそのホモログの機能または活性と比較
する工程、(c)上記(b)の比較結果に基づいて、配列番
号：261-313,362-365で示されるいずれかのアミノ酸配
列を有する蛋白質またはそのホモログの機能または活性
を抑制する被験物質を選択する工程。

【００３７】項21. 糖代謝異常疾患の予防、改善また
は治療剤の有効成分を探索するための方法である、項19
または項20に記載のスクリーニング方法。

【００３８】項22. 配列番号：1-260,314-361で示され
るいずれかの塩基配列を有する遺伝子の発現を抑制する
物質を有効成分とする糖代謝異常疾患の予防、改善また
は治療剤。

【００３９】項23. 遺伝子の発現を抑制する物質が項1
7に記載のスクリーニング法により得られるものである
項22に記載の糖代謝異常疾患の予防、改善または治療
剤。

【００４０】項24. 配列番号：261-313,362-365で示さ
れるいずれかのアミノ酸配列を有する蛋白質の発現量、
機能または活性を抑制する物質を有効成分とする糖代謝
異常疾患の予防、改善または治療剤。

【００４１】項25. 配列番号：261-313,362-365で示さ
れるいずれかのアミノ酸配列を有する蛋白質の発現量、
機能または活性を抑制する物質が、項19または項20に記
載のスクリーニング方法により得られるものである項24
に記載の糖代謝異常疾患の予防、改善または治療剤。

【００４２】

【発明の実施の形態】以下、本明細書において、アミノ
酸、(ポリ)ペプチド、(ポリ)ヌクレオチドなどの略号に
よる表示は、IUPAC-IUBの規定〔IUPAC-IUB Communicati
on on Biological Nomenclature, Eur. J. Biochem., 1
38: 9 (1984)〕、「塩基配列又はアミノ酸配列を含む明
細書等の作成のためのガイドライン」(日本国特許庁編)
および当該分野における慣用記号に従う。

【００４３】本明細書において「遺伝子」または「DN
A」とは、2本鎖DNAのみならず、それを構成するセンス
鎖およびアンチセンス鎖という各1本鎖DNAを包含する趣
旨で用いられる。またその長さによって特に制限される
ものではない。従って、本明細書において遺伝子(DNA)
とは、特に言及しない限り、ヒトゲノムDNAを含む2本鎖
DNAおよびcDNAを含む1本鎖DNA(正鎖)並びに該正鎖と相
補的な配列を有する1本鎖DNA(相補鎖)およびこれらの断
片のいずれもが含まれる。

【００４４】また当該「遺伝子」または「DNA」には、
特定の塩基配列で示される「遺伝子」または「DNA」だ
けでなく、これらによりコードされる蛋白質と生物学的
機能が同等である蛋白質(例えば、同族体、変異体、誘
導体など)をコードする「遺伝子」または「DNA」が包含
される。本明細書においては、これらを総括して上記特
定の塩基配列で示される「遺伝子」または「DNA」の
「ホモログ」ともいう。かかる「ホモログ」としては、
具体的には、後述の(1-1)項に記載のストリンジェント
な条件下で、前記特定塩基配列で示される「遺伝子」ま
たは「DNA」とハイブリダイズするものを挙げることが
できる。

【００４５】例えば同族体をコードする遺伝子(ホモロ
グ)としては、ヒト遺伝子に対応するマウスやラットな
どの他生物種の遺伝子が例示できる。これらの遺伝子
(ホモログ)は、HomoloGene（http://www.ncbi.nlm.nih.
gov/HomoloGene/）により同定することができる。具体
的には、特定ヒト塩基配列をBLAST (Proc. Natl. Acad.
Sci. USA., 90: 5873-5877, 1993、http://www.ncbi.n
lm.nih.gov/BLAST/)にかけて一致する(Scoreが最も高
く、E-valueが0でかつIdentityが100%を示す)配列のア
クセッション番号を取得する。そのアクセッション番号
をUniGene (http://www.ncbi.nlm.nih.gov/UniGene/)に
入力して得られたUniGene Cluster ID (Hs.で示す番号)
をHomoloGeneに入力する。結果として得られた他生物種
遺伝子とヒト遺伝子との遺伝子ホモログの相関を示した
リストから、ヒト遺伝子に該当するマウスやラットなど
の他生物種の遺伝子を選抜することができる。なお、遺
伝子またはDNAは、機能領域の別を問うものではなく、
例えば発現制御領域、コード領域、エキソンまたはイン
トロンを含むことができる。

【００４６】本明細書において「ポリヌクレオチド」と
は、RNAおよびDNAのいずれをも包含する趣旨で用いられ
る。なお、上記DNAには、cDNA、ゲノムDNAおよび合成DN
Aのいずれもが含まれる。また上記RNAには、total RN
A、mRNA、rRNAおよび合成のRNAのいずれもが含まれる。

【００４７】本明細書において「蛋白質」または「（ポ
リ)ペプチド」には、特定の塩基配列で示される「蛋白
質」または「（ポリ)ペプチド」だけでなく、これらと
生物学的機能が同等である「蛋白質」または「（ポリ)
ペプチド」（例えば、同族体、変異体、誘導体など）が
包含される。なお、本明細書においては、これらを上記
特定のアミノ酸配列で示される「蛋白質」または「（ポ
リ)ペプチド」の「ホモログ」ともいう。例えば、上記
同族体(ホモログ)としては、ヒトの蛋白質に該当するマ
ウスやラットなどの他生物種の蛋白質が例示できる。こ
れらはHomoloGene (http://www.ncbi.nlm.nih.gov/Homo
loGene/)により同定された遺伝子の塩基配列から演繹的
に同定することができる。また、上記変異体(ホモログ)
には、天然に存在するアレル変異体、天然に存在しない
変異体および人為的に欠失、置換、付加および挿入され
ることによって改変されたアミノ酸配列を有する変異体
が包含される。なお、かかる変異体(ホモログ)として
は、変異のない蛋白質または(ポリ)ペプチドと、少なく
とも70％、好ましくは80％、より好ましくは95％、さら
により好ましくは97％相同なものを挙げることができ
る。

【００４８】本明細書でいう「抗体」には、ポリクロー
ナル抗体、モノクローナル抗体、キメラ抗体、一本鎖抗
体、並びにFabフラグメントおよびFab発現ライブラリー
によって生成されるフラグメントのような抗原結合性を
有する上記抗体の一部が包含される。

【００４９】さらに本明細書において「疾患マーカー」
には、糖代謝異常疾患の罹患の有無もしくは罹患の程度
を診断するために、また、糖代謝異常疾患の改善、治療
などに有用な候補物質をスクリーニングするために、直
接または間接的に利用されるものであり、且つ、糖代謝
異常疾患に関連して生体内において、特に肝臓または筋
肉由来の細胞において、その発現が変動する(亢進され
る)遺伝子または蛋白質を特異的に認識し、またこれら
と結合することができる(ポリ)(オリゴ)ヌクレオチドま
たは抗体が包含される。これらの(ポリ)(オリゴ)ヌクレ
オチドおよび抗体は、上記性質に基づいて、生体内で発
現した上記遺伝子および蛋白質を検出するためのプロー
ブとして、また(オリゴ)ヌクレオチドはさらに生体内で
発現した上記遺伝子を増幅するためのプライマーとし
て、有効に利用することができる。

【００５０】本発明は、前述するように、配列番号：
1、2、3、4、5、6、7、8、9、10、11、12、13、14、1
5、16、17、18、19、20、21、22、23、24、25、26、2
7、28、29、30、31、32、33、34、35、36、37、38、3
9、40、41、42、43、44、45、46、47、48、49、50、5
1、52、53、54、55、56、57、58、59、60、61、62、6
3、64、65、66、67、68、69、70、71、72、73、74、7
5、76、77、78、79、80、81、82、83、84、85、86、8
7、88、89、90、91、92、93、94、95、96、97、98、9
9、100、101、102、103、104、105、106、107、108、10
9、110、111、112、113、114、115、116、117、118、11
9、120、121、122、123、124、125、126、127、128、12
9、130、131、132、133、134、135、136、137、138、13
9、140、141、142、143、144、145、146、147、148、14
9、150、151、152、153、154、155、156、157、158、15
9、160、161、162、163、164、165、166、167、168、16
9、170、171、172、173、174、175、176、177、178、17
9、180、181、182、183、184、185、186、187、188、18
9、190、191、192、193、194、195、196、197、198、19
9、200、201、202、203、204、205、206、207、208、20
9、210、211、212、213、214、215、216、217、218、21
9、220、221、222、223、224、225、226、227、228、22
9、230、231、232、233、234、235、236、237、238、23
9、240、241、242、243、244、245、246、247、248、24
9、250、251、252、253、254、255、256、257、258、25
9および260で示されるいずれかの塩基配列を有する遺伝
子(以下、これらの遺伝子を総称して遺伝子群Iともい
う)が、糖代謝異常疾患患者の肝臓においてその発現レ
ベルが有意に上昇していること、並びに配列番号：31
4、315、316、317、318、319、320、321、322、323、32
4、325、326、327、328、329、330、331、332、333、33
4、335、336、337、338、339、340、341、342、343、34
4、345、346、347、348、349、350、351、352、353、35
4、355、356、357、358、359、360および361で示される
いずれかの塩基配列を有する遺伝子(以下、これらの遺
伝子を総称して遺伝子群IIともいう)が、糖代謝異常疾
患患者の筋肉においてその発現レベルが有意に上昇して
いるとの知見を基礎として完成されている。即ち、本発
明は、これらの遺伝子の発現の有無および発現の程度を
検出することによって、糖代謝異常疾患の罹患の有無お
よび罹患の程度を検出でき、該疾患の診断を正確に行う
ことができるという発想に基づいている。

【００５１】これらの遺伝子およびその発現産物[蛋白
質、(ポリ)(オリゴ)ペプチド]は、糖代謝異常疾患の解
明、診断、予防および治療に有効に利用することがで
き、かかる利用によって医学並びに臨床学上、有用な情
報や手段を得ることができる。また、これらの遺伝子お
よびその発現産物並びにそれらからの派生物(例えば、
抗体など)は、上記糖代謝異常疾患の治療、並びに該治
療に有効に用いられる薬剤の開発に好適に利用すること
ができる。さらに、個体または肝臓もしくは筋肉組織に
おける上記遺伝子の発現またはその発現産物の検出、ま
たは該遺伝子の変異またはその発現不全の検出は、糖代
謝異常疾患の解明や診断に有効に利用することができ
る。

【００５２】以下、これらの遺伝子(ポリヌクレオチド)
並びにこれらの発現産物およびそれらの派生物について
具体的に説明する。

【００５３】(1)糖代謝異常疾患の疾患マーカーおよび
その応用 (1-1)ポリヌクレオチド 本発明ポリヌクレオチドは、被験者における上記遺伝子
の発現の有無およびその程度を検出することによって、
被験者が糖代謝異常疾患に罹患しているか否かおよびそ
の疾患の程度を診断するツール(疾患マーカー)として有
用である。

【００５４】また、本発明ポリヌクレオチドは、後述の
(3-1)項に記載するような糖代謝異常疾患の予防、改善
または治療に有用な候補物質のスクリーニングにおい
て、配列番号1-260,314-361で示されるいずれかの塩基
配列を有する遺伝子の発現を抑制する被験物質を検出す
るためのスクリーニングツール(疾患マーカー)としても
有用である。

【００５５】本発明疾患マーカーは、配列番号：1-260,
314-361で示されるいずれかの塩基配列において、連続
する少なくとも15塩基を有するポリヌクレオチドおよび
／または該ポリヌクレオチドに相補的なポリヌクレオチ
ドであることを特徴とする。

【００５６】ここで相補的なポリヌクレオチド(相補
鎖、逆鎖)とは、上記各配列番号で示される塩基配列か
らなるポリヌクレオチドの全長配列または該塩基配列に
おいて少なくとも連続した15塩基長の部分配列(ここで
は便宜上、これらを「正鎖」ともいう)に対して、A:Tお
よびG:Cといった塩基対関係に基づいて、塩基的に相補
的な関係にあるポリヌクレオチドを意味する。ただし、
かかる相補鎖は、対象とする正鎖の塩基配列と完全に相
補配列を形成する場合に限らず、対象とする正鎖とスト
リンジェントな条件でハイブリダイスすることができる
程度の相補関係を有するものであってもよい。なお、こ
こでストリンジェントな条件は、Berger andKimmel (19
87, Guide to Molecular Cloning Techniques Methods
in Enzymology, Vol. 152, Academic Press, San Diego
CA)に教示されるように、複合体或いはプローブを結合
する核酸の融解温度(Tm)に基づいて決定することができ
る。例えば、ハイブリダイズ後の洗浄条件として、通常
「1×SSC、0.1％SDS、37℃」程度の条件を挙げることが
できる。相補鎖はかかる条件で洗浄しても対象とする正
鎖とハイブリダイズ状態を維持するものであることが好
ましい。特に好まして相補鎖は、より厳しいハイブリダ
イズ条件、例えば「0.5×SSC、0.1％SDS、42℃」程度、
さらに厳しいハイブリダイズ条件、例えば「0.1×SSC、
0.1％SDS、65℃」程度、の洗浄条件で洗浄しても対象と
する正鎖とハイブリダイズ状態を維持するものである。
具体的には、このような相補鎖として、対象の正鎖の塩
基配列と完全に相補的な関係にある塩基配列からなる鎖
並びに該鎖と少なくとも90％、好ましくは95％の相同性
を有する塩基配列からなる鎖を例示することができる。

【００５７】また、正鎖側のポリヌクレオチドには、配
列番号：1-260, 314-361で示されるいずれかの塩基配列
またはその部分配列を有するものだけでなく、上記相補
鎖の塩基配列に対してさらに相補的な関係にある塩基配
列からなる鎖を含めることができる。

【００５８】さらに正鎖のポリヌクレオチドおよび相補
鎖(逆鎖)のポリヌクレオチドは、各々一本鎖の形態で疾
患マーカーとして使用されても、また二本鎖の形態で疾
患マーカーとして使用されてもよい。

【００５９】本発明の糖代謝異常疾患の疾患マーカー
は、具体的には配列番号：1-260, 314-361で示されるい
ずれかの塩基配列(全長配列)からなるポリヌクレオチド
であってもよいし、その相補配列からなるポリヌクレオ
チドであってもよい。また、配列番号：1-260, 314-361
で示されるいずれかの遺伝子もしくは該遺伝子に由来す
るポリヌクレオチドを選択的に(特異的に)認識するもの
であれば、上記全長配列もしくはその相補配列の部分配
列からなるポリヌクレオチドであってもよい。この場
合、部分配列としては、上記全長配列もしくはその相補
配列の塩基配列から任意に選択される少なくとも15個の
連続した塩基長を有するポリヌクレオチドを挙げること
ができる。

【００６０】なお、ここで「選択的に(特異的に)認識す
る」とは、例えばノーザンブロット法においては、配列
番号：1-260, 314-361で示されるいずれかの塩基配列を
有する遺伝子またはこれらの遺伝子に由来するポリヌク
レオチドが特異的に検出できること、またRT-PCR法にお
いては、配列番号：1-260, 314-361で示されるいずれか
の塩基配列を有する遺伝子またはこれらの遺伝子に由来
するポリヌクレオチドが特異的に生成されることを意味
するが、それらに限定されることなく、当業者が上記検
出物または生成物がこれらの遺伝子に由来するものであ
ると判断できるものであればよい。

【００６１】本発明疾患マーカーは、検出(認識)対象の
遺伝子(配列番号：1-260, 314-361)に応じて、配列番
号：1-260, 314-361のいずれかに示される塩基配列をも
とにして、例えばprimer 3(http://www.genome.wi.mit.
edu/cgi-bin/primer/primer3.cgi)あるいはベクターNTI
(Infomax社製)を利用して設計することができる。具体
的には上記検出対象とする遺伝子の塩基配列をprimer 3
またはベクターNTIのソフトウエアにかけて得られる、
プライマーまたはプローブの候補配列もしくは少なくと
も該配列を一部に含む配列をプライマーまたはプローブ
として使用して設計することができる。

【００６２】本発明疾患マーカーは、上述するように連
続する少なくとも15塩基の長さを有するものであればよ
く、具体的には該マーカーの用途に応じて、その長さを
適宜選択し設定することができる。

【００６３】(1-2)プローブまたはプライマーとしての
ポリヌクレオチド 本発明疾患マーカーは、上記各遺伝子の発現によって生
じたRNAまたはそれに由来するポリヌクレオチドを特異
的に認識し増幅するためのプライマーとしてまたは該RN
Aまたはそれに由来するポリヌクレオチドを特異的に検
出するためのプローブとして利用することができる。

【００６４】糖代謝異常疾患の検出(遺伝子診断)にプラ
イマーとして用いる本発明疾患マーカーは、通常15-100
bp、好ましくは15-50bp、より好ましくは15-35bpの塩基
長を有するものとすることができる。また検出プローブ
として用いる本発明疾患マーカーは、通常15bp-全配列
の塩基数、好ましくは15bp-1kb、より好ましくは100bp-
1kbの塩基長を有するものとすることができる。

【００６５】本発明の疾患マーカーは、ノーザンブロッ
ト法、RT-PCR法、in situハイブリダーゼーション法な
どの、特定遺伝子を特異的に検出する公知の方法におい
て、常法に従ってプライマーまたはプローブとして利用
することができる。該利用によって糖代謝異常疾患に関
連する配列番号：1-260, 314-361で示されるいずれかの
塩基配列を有する遺伝子の発現の有無または発現レベル
(発現量)を評価することができる。

【００６６】測定対象試料としては、使用する検出法の
種類に応じて適宜選択することができる。例えば被験者
の筋肉または肝臓の一部をバイオプシなどで採取し、そ
こから常法に従って調製したtotal RNAであってもよい
し、さらに該RNAをもとにして調製される各種のポリヌ
クレオチドであってもよい。

【００６７】配列番号：1-260, 314-361で示されるいず
れかの塩基配列を有する遺伝子の生体組織における発現
レベルは、DNAチップを利用して検出あるいは定量する
ことができる(例えば、Affymetrix社のGene Chip Human
Genome U95 A, B, C, D, Eの場合、25bpの長さのポリ
ヌクレオチドプローブとして用いられる）。この場合、
本発明疾患マーカーは当該DNAチップのプローブとして
使用することができる。かかるDNAチップを、生体組織
から採取したRNAをもとに調製される標識DNAまたはRNA
とハイブリダイズさせることにより、本発明疾患マーカ
ー(プローブ)と標識DNAまたはRNAとの複合体が形成され
るので、該複合体を該標識DNAまたはRNAの標識を指標と
して検出することにより、配列番号：1-260, 314-361で
示されるいずれかの塩基配列からなる遺伝子の生体組織
中での発現の有無または発現レベル(発現量)が評価でき
る。

【００６８】なお、上記DNAチップは、配列番号：1-26
0, 314-361で示される塩基配列を有する遺伝子と結合し
得る1種または2種以上の本発明疾患マーカーを含んでい
ればよい。複数の疾患マーカーを含むDNAチップの利用
によれば、ひとつに生体試料について、同時に複数の遺
伝子の発現の有無または発現レベルの評価が可能であ
る。

【００６９】本発明疾患マーカーは、糖代謝異常疾患の
診断および検出(罹患の有無、罹患の程度の診断など）
に有用である。具体的には、該疾患マーカーを利用した
糖代謝異常疾患の診断は、被験者と正常者との、それぞ
れの肝臓または筋肉における配列番号：1-260, 314-361
で示されるいずれかの塩基配列を有する遺伝子の遺伝子
発現レベルの違いを判定することによって行うことがで
きる。

【００７０】この場合、遺伝子発現レベルの違いには、
発現のある／なしの違いだけでなく、被験者と正常者と
を対比して、両者ともに発現がある場合でも、両者間の
発現量に有意な格差がある場合、例えばその格差が2倍
以上、好ましくは3倍以上ある場合が含まれる。

【００７１】より具体的には、配列番号：1-260の塩基
配列を有する遺伝子は、糖代謝異常疾患患者の肝臓にお
いてその発現の有意な上昇が認められるので、被験者の
肝臓において特異的に発現しているか或いは該発現量が
正常な肝臓における発現量と比べて、好ましくは2倍以
上、より好ましくは3倍以上上昇していれば、被験者に
ついて糖代謝異常疾患の罹患が疑われる。この場合の糖
代謝異常疾患の検出（診断）には、上記遺伝子に対応す
るいずれかの塩基配列(配列番号：1-260)において、連
続する少なくとも15塩基長を有するポリヌクレオチド／
または該ポリヌクレオチドに相補的なポリヌクレオチド
からなる本発明疾患マーカーが有用である。

【００７２】なかでも、配列番号：1、2、3、4、164、1
65、166または167で示されるいずれかの塩基配列を有す
る遺伝子は、正常な肝臓に比べて糖代謝異常疾患患者の
肝臓において、ほぼ10倍程度以上の発現増大を示す。従
って、これらの塩基配列において少なくとも15塩基長を
有するポリヌクレオチドまたはそれに相補的なポリヌク
レオチドからなる本発明疾患マーカーは特に有用であ
る。

【００７３】一方、配列番号：314-361の塩基配列を有
する遺伝子は、糖代謝異常疾患患者の筋肉においてその
発現の有意な上昇が認められるので、被験者の筋肉にお
いて特異的に発現しているか或いは該発現量が正常な筋
肉における発現量と比べて、好ましくは2倍以上、より
好ましくは3倍以上上昇していれば、被験者について糖
代謝異常疾患の罹患が疑われる。この場合の糖代謝異常
疾患の検出（診断）には、上記遺伝子に対応するいずれ
かの塩基配列(配列番号：314-361)において、連続する
少なくとも15塩基長を有するポリヌクレオチド／または
該ポリヌクレオチドに相補的なポリヌクレオチドからな
る本発明疾患マーカーが有用である。

【００７４】本発明における糖代謝異常疾患の検出(診
断)は、被験者の生体試料、特に肝臓または筋肉におけ
る配列番号：1-260, 314-361のいずれかの塩基配列を有
する遺伝子の少なくとも1つの発現の有無または発現レ
ベル(発現量)を評価することによって行われる。検出
(診断)の精度、正確性などを高めるためには、肝臓およ
び筋肉のそれぞれに対して、上記遺伝子のうち2以上、
好ましくは複数個、より好ましくは上記遺伝子群の4分
の1以上、さらに好ましくは上記遺伝子群の半数以上の
遺伝子について、その発現の有無または発現レベル(発
現量)を評価するのが望ましい。

【００７５】(1-3)抗体 また本発明は、糖代謝異常疾患の疾患マーカーとして配
列番号：1-260,314-361で示されるいずれかの塩基配列
を有する遺伝子の発現産物（蛋白質）を特異的に認識す
ることができる抗体を提供する。その例としては、例え
ば配列番号：12、17、18、23、25、26、33、34、35、3
9、44、47、53、58、61、69、70、73、75、76、79、8
9、93、94、95、96、98、102、103、104、106、107、10
9、122、123、124、125、130、131、134、136、138、13
9、141、145、146、148、149、150、151、159、160、16
3、328、331、333および340で示されるいずれかの塩基
配列を有する遺伝子によってコードされる蛋白質を挙げ
ることができる。これら各塩基配列によってコードされ
るアミノ酸配列の具体例は、例えば配列番号：261-313,
362-365に示す通りである。これらの塩基配列とアミノ
酸配列との関連については、後記実施例中の表1-表5が
参照される。

【００７６】本発明抗体は、その形態に特に制限はな
く、上記蛋白質を免疫抗原とするポリクローナル抗体で
あっても、またモノクローナル抗体であってもよい。さ
らに当該蛋白質を構成するアミノ酸配列のうち少なくと
も連続する、通常8アミノ酸、好ましくは15アミノ酸、
より好ましくは20アミノ酸からなるポリペプチドに対し
て抗原結合性を有する抗体も、本発明の抗体に含まれ
る。

【００７７】これらの抗体は、周知の方法により製造で
きる(Current protocols in Molecular Biology edit．
Ausubel et al．(1987) Publish. John Wiley and Son
s. Section 11.12-11.13）。具体的には、ポリクローナ
ル抗体は、常法に従って大腸菌などで発現し、精製した
上記蛋白質を用いて、あるいは常法に従って当該蛋白質
の部分アミノ酸配列を有するオリゴペプチドを合成し
て、家兎などの非ヒト動物に免疫し、該免疫動物の血清
から常法に従って得ることが可能である。一方、モノク
ローナル抗体は、常法に従って大腸菌などで発現し、精
製した上記蛋白質または該蛋白質の部分アミノ酸配列を
有するオリゴペプチドをマウスなどの非ヒト動物に免疫
し、得られた脾臓細胞と骨髄腫細胞とを細胞融合させて
調製したハイブリドーマ細胞から得ることができる(Cur
rent protocols in Molecular Biology edit. Ausubel
et al. (1987) Publish. John Wiley and Sons. Sectio
n 11.4-11.11）。

【００７８】抗体の作製に免疫抗原として使用される蛋
白質は、本発明により提供される遺伝子の配列情報(配
列番号：1-260, 314-361)、具体的には、配列番号：1
2、17、18、23、25、26、33、34、35、39、44、47、5
3、58、61、69、70、73、75、76、79、89、93、94、9
5、96、98、102、103、104、106、107、109、122、12
3、124、125、130、131、134、136、138、139、141、14
5、146、148、149、150、151、159、160、163、328、33
1、333および340で示される遺伝子の配列情報に基づい
て、DNAクローニング、各プラスミドの構築、宿主への
トランスフェクション、形質転換体の培養および培養物
からの蛋白質の回収の操作により得ることができる。こ
れらの操作は、当業者に既知の方法あるいは文献記載の
方法(Molecular Cloning, T. Maniatis et al., CSH La
boratory (1983); DNA Cloning, DM. Glover, IRL PRES
S (1985))などに準じて行うことができる。

【００７９】より具体的には、配列番号：261、262、26
3、264、265、266、267、268、269、270、271、272、27
3、274、275、276、277、278、279、280、281、282、28
3、284、285、286、287、288、289、290、291、292、29
3、294、295、296、297、298、299、300、301、302、30
3、304、305、306、307、308、309、310、311、312、31
3、362、363、364または365(配列番号：261-313, 362-3
65)で示されるいずれかのアミノ酸配列を有する蛋白質
をコードする遺伝子が所望の宿主細胞中で発現できる組
み換えDNA(発現ベクター)を作製し、これを宿主細胞に
導入して形質転換し、該形質転換体を培養して、得られ
る培養物から、目的蛋白質を回収することによって、本
発明抗体の製造のための免疫抗原としての蛋白質を得る
ことができる。また、これらの蛋白質は、本発明により
提供される遺伝子情報から常法によって得られるアミノ
酸配列および／または本発明により提供されるアミノ酸
配列情報に従って、一般的な化学合成法(ペプチド合成)
によって製造することもできる。

【００８０】なお、上記蛋白質には、配列番号：1-260,
314-361のいずれかの塩基配列を有する遺伝子によりコ
ードされる蛋白質、具体的には配列番号：12、17、18、
23、25、26、33、34、35、39、44、47、53、58、61、6
9、70、73、75、76、79、89、93、94、95、96、98、10
2、103、104、106、107、109、122、123、124、125、13
0、131、134、136、138、139、141、145、146、148、14
9、150、151、159、160、163、328、331、333および340
で示される遺伝子によりコードされる蛋白質(配列番
号：261-313, 362-365で示されるいずれかのアミノ酸配
列を有する蛋白質)のみならず、これらの相同物も包含
される。該相同物としては、上記遺伝子によってコード
される蛋白質のアミノ酸配列、例えば具体的には配列番
号：261-313,362-365で示されるいずれかのアミノ酸配
列において、1もしくは複数(通常数個)のアミノ酸が欠
失、置換または付加されたアミノ酸配列からなり且つ各
アミノ酸配列の蛋白質の機能(公知)と同等の生物学的機
能を有する蛋白質および／または同等の免疫学的活性を
有する蛋白質を挙げることができる。

【００８１】ここで、「同等の生物学的機能」を有する
蛋白質としては、各々対応する蛋白質(具体的には、配
列番号：261-313, 362-365で示されるアミノ酸配列を有
する蛋白質)と、生化学的または薬理学的機能において
同等の機能を有する蛋白質を挙げることができる。ま
た、「同等の免疫学的活性」を有する蛋白質としては、
適当な動物あるいはその細胞において特定の免疫反応を
誘発し、かつ各対応する蛋白質に対する抗体と特異的に
結合する能力を有する蛋白質を挙げることができる。

【００８２】なお、蛋白質におけるアミノ酸の変異数お
よび変異部位は、その生物学的機能および／または免疫
学的活性が保持される限り制限はない。生物学的機能ま
たは免疫学的活性を消失することなくアミノ酸残基が、
どのように、何個置換、挿入あるいは欠失され得るかを
決定する指標は、当業者に周知のコンピュータプログラ
ム、例えばDNA Star softwareを用いて見出すことがで
きる。例えば、変異数は、典型的には、全アミノ酸の10
％以内であり、好ましくは全アミノ酸の5％以内であ
り、さらに好ましくは全アミノ酸の1％以内である。ま
た置換されるアミノ酸は、置換後に得られる蛋白質が、
置換前の蛋白質の生物学的機能および／または免疫学的
活性を保持している限り、特に制限されないが、この置
換されるアミノ酸は、蛋白質の構造保持の観点から、ア
ミノ酸の極性、電荷、可溶性、疎水性、親水性、両親媒
性などにおいて置換前のアミノ酸と似た性質を有するア
ミノ酸であることが好ましい。例えば、Ala、Val、Le
u、Ile、Pro、Met、PheおよびTrpは、互いに非極性アミ
ノ酸に分類されるアミノ酸である。Gly、Ser、Thr、Cy
s、Tyr、AsnおよびGlnは互いに非荷電性アミノ酸に分類
されるアミノ酸である。AspおよびGluは互いに酸性アミ
ノ酸に分類されるアミノ酸である。また、Lys、Argおよ
びHisは互いに塩基性アミノ酸に分類されるアミノ酸で
ある。ゆえに、これらを指標として同群に属するアミノ
酸を適宜選択することができる。

【００８３】本発明抗体は、また、配列番号：1-260, 3
14-361で示されるいずれかの塩基配列を有する遺伝子に
よりコードされる蛋白質、具体的には配列番号：12、1
7、18、23、25、26、33、34、35、39、44、47、53、5
8、61、69、70、73、75、76、79、89、93、94、95、9
6、98、102、103、104、106、107、109、122、123、12
4、125、130、131、134、136、138、139、141、145、14
6、148、149、150、151、159、160、163、328、331、33
3および340で示されるいずれかの塩基配列を有する遺伝
子によりコードされる蛋白質(配列番号：261-313, 362-
365で示されるいずれかのアミノ酸配列を有する蛋白質)
の部分アミノ酸配列を有するオリゴペプチドを用いて調
製されるものであってもよい。かかる抗体の製造のため
に用いられるオリゴペプチドは、機能的な生物活性を有
することは要しないが、各々対応する蛋白質と同様の免
疫原特性を有するものであることが望ましい。好ましく
はこの免疫原特性を有し且つ配列番号：1-260, 314-361
で示されるいずれかの塩基配列を有する遺伝子によりコ
ードされる蛋白質のアミノ酸配列、具体的には配列番
号：12、17、18、23、25、26、33、34、35、39、44、4
7、53、58、61、69、70、73、75、76、79、89、93、9
4、95、96、98、102、103、104、106、107、109、122、
123、124、125、130、131、134、136、138、139、141、
145、146、148、149、150、151、159、160、163、328、
331、333および340で示されるいずれかの塩基配列を有
する遺伝子によりコードされる蛋白質のアミノ酸配列
(配列番号：261-313, 362-365で示されるいずれかのア
ミノ酸配列)において、少なくとも連続する、通常8アミ
ノ酸、好ましくは15アミノ酸、より好ましくは20アミノ
酸からなるオリゴペプチドを例示することができる。

【００８４】かかるオリゴペプチドに対する抗体の製造
は、宿主に応じて種々のアジュバントを用いて免疫学的
反応を高めることによって行うこともできる。限定はさ
れないが、そのようなアジュバントには、フロイントア
ジュバント、水酸化アルミニウムのようなミネラルゲ
ル、並びにリゾレシチン、プルロニックポリオル、ポリ
アニオン、ペプチド、油乳剤、キーホールリンペットヘ
モシアニンおよびジニトロフェノールのような表面活性
物質、BCG(カルメット−ゲラン桿菌)、コリネバクテリ
ウム-パルヴムなどのヒトアジュバントが含まれる。

【００８５】本発明抗体は、配列番号：1-260, 314-361
で示されるいずれかの塩基配列を有する遺伝子によりコ
ードされる蛋白質、具体的には配列番号：12、17、18、
23、25、26、33、34、35、39、44、47、53、58、61、6
9、70、73、75、76、79、89、93、94、95、96、98、10
2、103、104、106、107、109、122、123、124、125、13
0、131、134、136、138、139、141、145、146、148、14
9、150、151、159、160、163、328、331、333および340
で示されるいずれかの塩基配列を有する遺伝子によりコ
ードされる蛋白質(配列番号：261-313, 362-365で示さ
れるいずれかのアミノ酸配列を有する蛋白質)に特異的
に結合する性質を有することから、該抗体を利用するこ
とによって、被験者の組織内に発現した上記蛋白質を特
異的に検出することができる。すなわち、当該抗体は被
験者の組織内における上記蛋白質の発現の有無および発
現の程度を検出するためのプローブとして有用である。

【００８６】具体的には、患者の肝臓または筋肉の一部
（生体試料）をバイオプシなどで採取し、そこから常法
に従って蛋白質を調製して、例えばウェスタンブロット
法、ELISA法などの公知の検出方法において、上記抗体
を常法に従ってプローブとして使用することによって、
上記生体試料中に存在する蛋白質を検出することができ
る。

【００８７】糖代謝異常疾患の診断に際しては、被験者
の肝臓または筋肉に存在する、配列番号：1-260, 314-3
61で示されるいずれかの塩基配列を有する遺伝子により
コードされる蛋白質、具体的には配列番号：12、17、1
8、23、25、26、33、34、35、39、44、47、53、58、6
1、69、70、73、75、76、79、89、93、94、95、96、9
8、102、103、104、106、107、109、122、123、124、12
5、130、131、134、136、138、139、141、145、146、14
8、149、150、151、159、160、163、328、331、333およ
び340で示されるいずれかの塩基配列を有する遺伝子に
よりコードされる蛋白質(配列番号：261-313, 362-365
で示されるいずれかのアミノ酸配列を有する蛋白質)の
いずれか少なくとも1つの量を、正常な肝臓または筋肉
に存在する、対応する蛋白質量と対比して、その違いを
判定すればよい。この場合、蛋白質量の違いには、蛋白
質が存在する／存在しないの相違とともに、蛋白質量の
差が2倍以上、好ましくは3倍以上の場合が含まれる。

【００８８】配列番号：1-260で示される塩基配列を有
する遺伝子は、糖代謝異常疾患患者の肝臓で有意にその
発現が増大し、その発現産物量も増大するので、被験者
の肝臓由来の組織または細胞における上記遺伝子の発現
産物(上記遺伝子によってコードされる蛋白質、具体的
には配列番号：261-313で示されるアミノ酸配列を有す
る蛋白質)の量が正常な肝臓における同遺伝子発現産物
量と比べて2倍以上、好ましくは3倍以上多いことが判定
されれば、糖代謝異常疾患の罹患が疑われる。この場
合、糖代謝異常疾患の検出(診断)には、各々の遺伝子が
コードする蛋白質、より具体的には配列番号：12、17、
18、23、25、26、33、34、35、39、44、47、53、58、6
1、69、70、73、75、76、79、89、93、94、95、96、9
8、102、103、104、106、107、109、122、123、124、12
5、130、131、134、136、138、139、141、145、146、14
8、149、150、151、159、160または163に例示される塩
基配列を有する遺伝子がコードする蛋白質(配列番号：2
61-313で示されるアミノ酸配列を有する蛋白質)を特異
的に認識する抗体である本発明疾患マーカーが有用であ
る。

【００８９】また、配列番号：314-361で示される塩基
配列を有する遺伝子は、糖代謝異常疾患患者の筋肉で有
意にその発現が増大し、その発現産物量も増大するの
で、被験者の筋肉由来の組織または細胞における上記遺
伝子の発現産物(上記遺伝子によってコードされる蛋白
質、具体的には配列番号：362-365で示されるアミノ酸
配列を有する蛋白質)の量が正常な筋肉における同遺伝
子発現産物量と比べて2倍以上、好ましくは3倍以上多い
ことが判定されれば、糖代謝異常疾患の罹患が疑われ
る。この場合、糖代謝異常疾患の検出(診断)には、各々
の遺伝子がコードする蛋白質、より具体的には配列番
号：328、331、333または340に例示される塩基配列を有
する遺伝子がコードする蛋白質(配列番号：362-365で示
されるアミノ酸配列を有する蛋白質)を特異的に認識す
る抗体である本発明疾患マーカーが有用である。

【００９０】なかでも、配列番号：1、2、3、4、164、1
65、166または167で示される各塩基配列を有する遺伝子
は、糖代謝異常疾患患者の肝臓でほぼ10倍以上の発現上
昇が認められるので、これらの遺伝子によってコードさ
れる蛋白質を特異的に認識する抗体を有する疾患マーカ
ーが糖代謝異常疾患の検出（診断）に有用と思われる。

【００９１】(2)糖代謝異常疾患の検出方法(診断方法) 本発明は、前述した本発明疾患マーカーを利用した糖代
謝異常疾患の検出方法(診断方法)を提供する。

【００９２】本発明の検出方法は、具体的には、被験者
の肝臓の一部をバイオプシなどで採取し、そこに含まれ
る糖代謝異常疾患に関連する配列番号：1-260で示され
るいずれかの塩基配列を有する遺伝子の遺伝子発現レベ
ル、またはこれらの遺伝子に由来する蛋白質を検出し、
その発現量またはその蛋白質量を測定することにより、
糖代謝異常疾患の罹患の有無またはその程度を検出（診
断）するものである。

【００９３】また、本発明の検出方法は、被験者の筋肉
の一部をバイオプシなどで採取し、そこに含まれる糖代
謝異常疾患に関連する配列番号：314-361で示されるい
ずれかの塩基配列を有する遺伝子の遺伝子発現レベル、
またはこれらの遺伝子に由来する蛋白質を検出し、その
発現量またはその蛋白質量を測定することにより、糖代
謝異常疾患の罹患の有無またはその程度を検出（診断）
するものである。

【００９４】本発明の検出方法は、次の(a)、(b)および
(c)の工程を含むものである： (a) 被験者の生体試料と本発明疾患マーカーを接触さ
せる工程、(b) 生体試料中の配列番号：1-260, 314-36
1で示されるいずれかの塩基配列を有する遺伝子の遺伝
子発現レベル、またはこれらいずれかの遺伝子によって
コードされる蛋白質の量、具体的には配列番号：261-31
3, 362-365で示されるアミノ酸配列を有する蛋白質の量
を、上記疾患マーカーを指標として測定する工程、(c)
上記(b)の結果をもとに、糖代謝異常疾患の罹患を判断
する工程。

【００９５】ここで用いられる生体試料は、被験者の肝
臓または筋肉由来の組織または細胞から調製されるRNA
もしくはそれからさらに調製されるポリヌクレオチドま
たは上記組織などから調製される蛋白質である。かかる
RNA、ポリヌクレオチドまたは蛋白質は、被験者の組織
または細胞の一部をバイオプシーなどで採取し、そこか
ら常法に従って調製することができる。

【００９６】本発明の診断方法は、測定対象として用い
る生体試料の種類に応じて、具体的には下記のようにし
て実施される。

【００９７】(2-1) 生体試料としてRNAを利用する場合 診断に用いる生体試料としてRNAを利用する場合、本発
明検出方法(診断方法)は、該RNA中の配列番号：1-260
(生体試料が肝臓由来のものである場合)および314-361
(生体試料が筋肉由来のものである場合)で示されるいず
れかの塩基配列を有する遺伝子の発現レベルを検出し、
測定することによって実施される。

【００９８】この場合、本発明検出方法は、次の(a)、
(b)および(c)の工程を含む： (a) 被験者の生体試料と本発明疾患マーカーとを接触
させる工程、(b) 上記(a)工程によって本発明疾患マー
カーに結合した生体試料由来のRNAまたはそれから転写
された相補的なポリヌクレオチドを上記疾患マーカーを
指標として測定する工程、および(c) 上記(b)において
得られる結果をもとに、糖代謝異常疾患の罹患を判断す
る工程。

【００９９】本発明糖代謝異常疾患の検出方法(診断方
法)は、特に測定対象の生体試料としてRNAを利用して、
該RNA中の配列番号：1-260, 314-361で示されるいずれ
かの塩基配列を有する遺伝子の発現レベルを検出し、測
定することによって実施される。具体的には、上記検出
する遺伝子の塩基配列に応じて、前述する本発明疾患マ
ーカー(配列番号：1-260, 314-361で示されるいずれか
の塩基配列において連続する少なくとも15塩基を有する
ポリヌクレオチドおよび／または該ポリヌクレオチドに
相補的なポリヌクレオチド)をプライマーまたはプロー
ブとして用いて、ノーザンブロット法、RT-PCR法、DNA
チップ解析法、in situハイブリダイゼーション解析法
などの公知の方法を行うことにより実施できる。

【０１００】ノーザンブロット法を利用する場合、本発
明疾患マーカーをプローブとして用いることによって、
RNA中の配列番号：1-260, 314-361で示されるいずれか
の塩基配列を有する遺伝子の発現の有無および発現レベ
ルを検出、測定することができる。具体的には、本発明
疾患マーカー(相補鎖)を放射性同位元素(³²P、³³Pな
ど：RI)、蛍光物質などで標識する。次いで、得られる
標識疾患マーカーを常法に従ってナイロンメンブレンな
どにトランスファーした被験者の肝臓または筋肉に由来
するRNAとハイブリダイズさせる。その後、形成された
標識疾患マーカー(DNA)とRNAとの二重鎖を、該疾患マー
カーの標識物(RI、蛍光物質など)に由来するシグナルを
放射線検出器(BAS−1800II、富士フィルム社製)、蛍光
検出器などで検出、測定する方法を例示できる。

【０１０１】また、AlkPhos Direct Labelling and Det
ection System (Amersham Pharamcia Biotech社製)を用
いて、該プロトコールに従って疾患マーカー(プローブD
NA)を標識し、被験者の肝臓または筋肉に由来するRNAと
ハイブリダイズさせた後、疾患マーカーの標識物に由来
するシグナルをマルチバイオイメージャーSTORM860(Ame
rsham Pharmacia Biotech社製)で検出、測定する方法を
使用することもできる。

【０１０２】RT-PCR法を利用する場合、本発明疾患マー
カーをプライマーとして用いて、RNA中の配列番号：1-2
60, 314-361で示されるいずれかの塩基配列を有する遺
伝子の発現の有無および発現レベルを検出、測定するこ
とができる。具体的には、被験者の肝臓または筋肉由来
のRNAから常法に従ってcDNAを調製し、これを鋳型とし
て標的の遺伝子の領域が増幅できるように、本発明疾患
マーカーから調製した一対のプライマー(上記cDNA(−
鎖)に結合する正鎖、＋鎖に結合する逆鎖)をこれとハイ
ブリダイズさせる。その後、常法に従ってPCR法を行
い、得られた増幅二本鎖DNAを検出する方法を例示する
ことができる。

【０１０３】増幅された二本鎖DNAの検出には、上記PCR
を予めRI、蛍光物質などで標識しておいたプライマーを
用いて行うことによって産生される標識二本鎖DNAを検
出する方法、産生された二本鎖DNAを常法に従ってナイ
ロンメンブレンなどにトランスファーさせて、標識した
疾患マーカーをプローブとして使用してこれとハイブリ
ダイズさせて検出する方法などを用いることができる。
なお、生成された標識二本鎖DNA産物はアジレント2100
バイオアナライザ(横河アナリティカルシステムズ社製)
などで測定することができる。また、SYBR Green RT-PC
R Reagents (Applied Biosystems社製)で該プロトコー
ルに従ってRT-PCR反応液を調製し、ABI PRIME 7700 Seq
uence Detection System (Applied Biosystems 社製)で
反応させて、該反応物を検出することもできる。

【０１０４】また、DNAチップ解析を利用する場合、本
発明疾患マーカーをDNAプローブ(1本鎖または2本鎖)と
して貼り付けたDNAチップを用意し、これに被験者の肝
臓または筋肉由来のRNAから常法によって調製されたcRN
Aをハイブリダイズさせ、形成されたDNAとcRNAとの二本
鎖を、本発明疾患マーカーから調製される標識プローブ
と結合させて検出する方法を挙げることができる。上記
DNAチップとして配列番号：1-260, 314-361で示される
塩基配列を有する遺伝子の遺伝子発現レベルの検出、測
定が可能なDNAチップを用いることもできる。かかる遺
伝子の発現レベルを検出、測定することができるDNAチ
ップとしては、Affymetrix社のGene ChipHuman Genome
U95 A, B, C, D, Eを挙げることができる。かかるDNAチ
ップを用いた、被験者RNA中の配列番号：1-260, 314-36
1で示されるいずれかの塩基配列を有する遺伝子の遺伝
子発現レベルの検出、測定については、実施例において
詳細に説明する。

【０１０５】(2-2)生体試料として蛋白質を用いる場合 生体試料(測定対象物)として蛋白質を用いる場合、本発
明検出方法(診断方法)は、生体試料中に存在する配列番
号：1-260, 314-361で示されるいずれかの塩基配列を有
する遺伝子によってコードされる蛋白質、より具体的に
は配列番号：12、17、18、23、25、26、33、34、35、3
9、44、47、53、58、61、69、70、73、75、76、79、8
9、93、94、95、96、98、102、103、104、106、107、10
9、122、123、124、125、130、131、134、136、138、13
9、141、145、146、148、149、150、151、159、160、16
3、328、331、333および340で示されるいずれかに記載
の塩基配列を有する遺伝子によってコードされる蛋白質
(配列番号：261-313, 362-365で示されるアミノ酸配列
を有する蛋白質)を検出し、その発現蛋白量（レベル）
を測定することによって実施される。より詳細には、上
記蛋白質を認識する抗体を疾患マーカーとして用いてウ
エスタンブロット法などの公知方法で、該蛋白質レベル
を検出、定量する。

【０１０６】ウエスタンブロット法は、一次抗体として
本発明疾患マーカーを用いた後、二次抗体として一次抗
体に結合する抗体を¹²⁵Iなどの放射性同位元素、蛍光物
質などで標識した標識抗体を用い、得られる標識された
蛋白質における放射性同位元素もしくは蛍光物質由来の
シグナルを、放射線測定器(BAS-1800II：富士フィルム
社製など)、蛍光検出器などで検出、測定することによ
って実施できる。また、一次抗体として本発明疾患マー
カーを用いた後、ECL Plus Western BlottingDetction
System (Amersham Pharmacia Biotech社製)を用いて、
該プロトコールに従って検出し、マルチバイオイメージ
ャーSTORM860(Amersham Pharmacia Biotech社製)で測定
することもできる。

【０１０７】尚、上記において測定対象とする蛋白質の
うちには、既に解明されている機能または活性を有する
ものが存在する。そのような蛋白質の場合、その蛋白質
量(レベル)と機能乃至活性とは一定の相関関係を有して
いるので、蛋白質量の測定に代えて、該蛋白質の機能ま
たは活性の測定を行うことによっても、本発明の糖代謝
異常疾患の検出(診断)を実施することができる。すなわ
ち、本発明は、かかる蛋白質の機能または活性を指標と
して、これを公知の方法に従って測定、評価することか
らなる、糖代謝異常疾患の検出(診断)方法をも包含す
る。

【０１０８】例えば、蛋白質が既知の酵素である場合、
上記機能(活性)には当該酵素に対する基質の修飾活性や
切断活性が含まれ、これらは、例えば基質修飾量や切断
量などの測定により求めることができる。

【０１０９】(2-3)糖代謝異常疾患の診断 糖代謝異常疾患の診断は、具体的には、被験者の肝臓に
おける配列番号：1-260で示されるいずれかの塩基配列
を有する遺伝子の遺伝子発現レベルまたは上記配列番号
に示される塩基配列を有する遺伝子の発現産物である蛋
白質、具体的には配列番号：261-313で示されるアミノ
酸配列を有する蛋白質の量（レベル）を、正常な肝臓に
おける当該遺伝子発現レベルまたは当該蛋白質量（レベ
ル）と比較し、両者の違いを判定することによって行う
ことができる。

【０１１０】また、糖代謝異常疾患の診断は、被験者の
筋肉における配列番号：314-361で示されるいずれかの
塩基配列を有する遺伝子の遺伝子発現レベルまたは上記
配列番号に示される塩基配列を有する遺伝子の発現産物
である蛋白質、具体的には配列番号：362-365で示され
るアミノ酸配列を有する蛋白質の量（レベル）を、正常
な肝臓における当該遺伝子発現レベルまたは当該蛋白質
量（レベル）と比較し、両者の違いを判定することによ
って行うことができる。

【０１１１】この場合、正常な組織などから採取調製し
た生体試料(RNAまたは蛋白質)が必要であるが、これは
糖代謝異常疾患に罹患していない人の肝臓または筋肉の
一部をバイオプシなどで採取することによって取得する
ことができる。なお、ここで「糖代謝異常疾患に罹患し
ていない人」とは、少なくとも糖代謝異常疾患の自覚症
状がなく、好ましくは他の検査方法、例えば経口糖負荷
試験法などによる検査の結果、糖代謝異常疾患でないと
診断された人をいう。当該「糖代謝異常疾患に罹患して
いない人」を以下、本明細書では単に正常者という場合
もある。

【０１１２】被験者の生体試料と正常者の生体試料との
遺伝子発現レベルまたは蛋白質レベルの比較は、両者の
生体試料を対象とした測定を並行して行うことで実施で
きる。また、並行して行なわなくても、複数(少なくと
も2、好ましくは3以上、より好ましくは5以上)の正常者
の生体試料を用いて均一な測定条件で測定して得られた
上記遺伝子発現レベルもしくはこれらの遺伝子の発現産
物である蛋白質レベルの平均値または統計的中間値を予
め求めて正常レベルもしくは正常値とし、これらを被験
者における測定レベルもしくは測定値と比較することも
できる。

【０１１３】被験者が、糖代謝異常疾患であるかどうか
の判断は、生体試料として肝臓由来組織乃至細胞を利用
する場合、該被験者の生体試料における配列番号：1-26
0で示されるいずれかの塩基配列を有する遺伝子の遺伝
子発現レベル、または上記配列番号で示される塩基配列
を有する遺伝子の発現産物である蛋白質レベル、例えば
具体的には配列番号：261-313で示されるアミノ酸配列
を有する蛋白質のレベルが、正常者のそれらと比較して
有意に多いか否かを指標として行われる。具体的には、
上記被験者の遺伝子発現レベルまたは蛋白質レベルが正
常者のそれらと比較して、2倍以上、好ましくは3倍以上
多い場合に、該被験者について糖代謝異常疾患が疑われ
る。

【０１１４】また、生体試料として筋肉由来組織乃至細
胞を利用する場合、被験者の生体試料における配列番
号：314-361で示されるいずれかの塩基配列を有する遺
伝子の遺伝子発現レベル、または上記配列番号で示され
る塩基配列を有する遺伝子の発現産物である蛋白質、例
えば具体的には配列番号：362-365で示されるアミノ酸
配列を有する蛋白質のレベルが、正常者のそれらと比較
して有意に多い場合、具体的には、2倍以上、好ましく
は3倍以上多い場合には、該被験者について糖代謝異常
疾患が疑われる。

【０１１５】なお、前記(2-1)に示す方法に従い、生体
試料としてRNAを利用して糖代謝異常疾患を検出(診断)
する場合、すなわち遺伝子発現の有無または遺伝子発現
レベル(発現量)から糖代謝異常疾患を検出(診断)する場
合、検出(診断)の精度、正確性などを高めるために、肝
臓由来の生体試料については、配列番号：1-260に示さ
れる遺伝子のうち2以上、好ましくは複数個、より好ま
しくは上記遺伝子群の4分の1以上、さらにより好ましく
は半数以上について、発現の有無または発現レベル(発
現量)を評価し、その結果から糖代謝異常疾患を検出(診
断)することが望ましい。また、筋肉由来の生体試料に
ついては、配列番号：314-361に示される遺伝子のうち2
以上、好ましくは複数個、より好ましくは上記遺伝子群
の4分の1以上、さらにより好ましくは半数以上につい
て、発現の有無または発現レベル(発現量)を評価し、そ
の結果から糖代謝異常疾患を検出(診断)することが望ま
しい。

【０１１６】前記(2-2)に示す方法に従って測定対象物
として蛋白質を利用して糖代謝異常疾患を検出(診断)す
る場合も、上記と同様に、生体試料について、配列番
号：1-260,314-361に示される遺伝子によってコードさ
れる蛋白質のうち2以上、好ましくは複数個の蛋白質の
レベル(発現量)を評価し、その結果から糖代謝異常疾患
を検出(診断)することが望ましい。

【０１１７】このように、複数個の遺伝子または蛋白質
について評価する場合には、個々の遺伝子または蛋白質
での評価をスコア化し、総合的に糖代謝異常疾患を診断
することが可能である。例えば、上記遺伝子または蛋白
質の中から任意の10個の遺伝子または蛋白質について評
価を行い、うち9個以上の遺伝子または蛋白質について
上記基準に基づいて糖代謝異常疾患の病態が疑われると
評価される場合は、該疾患である可能性が高いと診断で
きる。この場合、評価する遺伝子または蛋白質の数、ス
コアあるいは診断基準は限定されない。

【０１１８】（3）候補薬のスクリーニング方法 (3-1)遺伝子発現レベルを指標とするスクリーニング方
法 本発明は、配列番号：1-260, 314-361で示されるいずれ
かの塩基配列を有する遺伝子の発現を抑制する物質をス
クリーニングする方法を提供する。

【０１１９】本発明スクリーニング方法は、次の工程
(a)、(b)および(c)を含む： (a) 被験物質と配列番号：1-260, 314-361で示されるい
ずれかの塩基配列を有する遺伝子またはそのホモログを
発現可能な細胞とを接触させる工程、(b) 被験物質を接
触させた細胞における配列番号：1-260,314-361で示さ
れるいずれかの塩基配列を有する遺伝子またはそのホモ
ログの遺伝子発現量を測定し、該発現量を被験物質を接
触させない対照細胞における同一遺伝子またはそのホモ
ログの発現量と比較する工程、(c) 上記(b)の比較結果
に基づいて、上記遺伝子またはそのホモログの遺伝子発
現量を低下させる被験物質を選択する工程。

【０１２０】本発明スクリーニング法に用いられる細胞
としては、内在性および外来性を問わず、配列番号：1-
260, 314-361で示される塩基配列を有する遺伝子の少な
くともひとつを発現し得る細胞であって且つ肝臓もしく
は筋肉に由来する細胞を挙げることができる。またかか
る細胞として、配列番号：1-260, 314-361の塩基配列を
有する遺伝子のホモログ、すなわち当該遺伝子のヒト以
外の生物種における同族体または変異体をコードする遺
伝子を発現可能な細胞を使用することもできる。例えば
スクリーニング用細胞として、配列番号：1-260, 314-3
61のいずれかの塩基配列を有するヒト遺伝子に対応する
マウス、ラットなどのホモログ（遺伝子）を内在性に発
現しているマウス、ラットなどの肝臓もしくは筋肉由来
細胞を用いることができる。肝臓に由来する上記細胞
は、具体的には、配列番号：1-260で示される塩基配列
を有する遺伝子またはそのホモログの少なくともひとつ
を発現し得る細胞であり、例えば、高脂肪食を負荷して
作製した高脂肪食負荷マウス、または肥満糖尿病モデル
マウスであるC57BL/Ksj-db/dbJcIマウスもしくはKKAy/T
a Jclマウス(日本クレア)から単離、調製した初代肝臓
培養細胞などが包含される。また、HepG2細胞(肝癌細胞
株、ヒトhepatocellular carcinoma, ATCC寄託No. HB80
65)なども本発明スクリーニング法に肝臓由来細胞とし
て用いることができる。

【０１２１】また、筋肉に由来する上記細胞は、具体的
には、配列番号：314-361で示される塩基配列を有する
遺伝子またはそのホモログの少なくともひとつを発現し
得る細胞であり、例えば、高脂肪食を負荷して作製した
高脂肪食負荷マウス、または肥満糖尿病モデルマウスで
あるC57BL/Ksj-db/dbJcIマウスもしくはKKAy/Ta Jclマ
ウス(日本クレア)から単離、調製した初代筋肉培養細胞
などを挙げることができる。また、L6筋筒細胞(筋培養
株、ATCC寄託株)なども本発明スクリーニング法に筋肉
由来細胞として用いることができる。

【０１２２】さらに、本発明スクリーニングに用いられ
る細胞の範疇には、細胞の集合体である組織も含まれ
る。

【０１２３】本発明スクリーニング法によってスクリー
ニングされ得る被検物質(候補物質)は、制限されない
が、核酸(配列番号：1-260, 314-361のいずれかの塩基
配列を有する遺伝子またはそのホモログのアンチセンス
オリゴヌクレオチドを含む)、ペプチド、蛋白質、有機
化合物、無機化合物などである。本発明のスクリーニン
グ法は、具体的にはこれらの候補物質またはこれらの候
補物質を含む試料(被験試料)を、上記細胞および／また
は組織と接触させることにより実施される。被験試料と
しては、被験物質を含む、細胞抽出液、遺伝子ライブラ
リーの発現産物、合成低分子化合物、合成ペプチド、天
然化合物などが挙げられるが、これに制限されない。

【０１２４】本発明スクリーニングに際して、被験物質
と細胞とを接触させる条件は、該細胞が死滅せず且つ所
望の遺伝子を発現できる条件(培養温度、培養pH、培地
組成など)を適宜選択することができる。

【０１２５】実施例に示すように、糖代謝異常疾患に罹
患した患者の肝臓および／または筋肉では、配列番号：
1-260, 314-361で示されるいずれかの塩基配列を有する
遺伝子の発現が有意に上昇している。本発明スクリーニ
ング法は、この特定遺伝子の発現の上昇が糖代謝異常疾
患と関連することを利用するものである。即ち、本発明
のスクリーニング方法には、これらの遺伝子またはその
ホモログの発現レベルの上昇を指標として、その発現レ
ベルを抑制する物質（正常レベルに戻す物質）を探索す
る方法が含まれる。この本発明スクリーニング方法によ
って、糖代謝異常疾患の緩和／抑制作用を有する候補物
質(糖代謝異常疾患に対して改善／治療効果を発揮する
候補物質)を探索することができ、かくして、糖代謝異
常疾患の予防薬、改善薬または治療薬の有効成分となる
候補物質を提供することができる。

【０１２６】候補物質は、被験物質(候補物質)の存在下
で培養した細胞における上記特定遺伝子の発現レベル
を、被験物質(候補物質)の非存在下で培養した対照細胞
における同一遺伝子の発現レベルと対比して、これが有
意に低下する場合に、その選別を行うことができる。

【０１２７】より具体的には、例えば、高脂肪食負荷マ
ウス、C57BL/Ksj-db/db JclマウスもしくはKKAy/Ta Jcl
マウスから単離・調製した初代肝臓培養細胞、HepG2細
胞などを用いて糖代謝異常疾患の予防、改善または治療
薬の有効成分となる候補物質をスクリーニングする場合
は、被験物質を加えた前記細胞における配列番号：1-26
0で示されるいずれかの塩基配列を有する遺伝子または
そのホモログの発現レベルを、溶媒のみを加えた前記初
代肝臓培養細胞(対照細胞)における同遺伝子またはその
ホモログの発現レベルと比較し、その発現の減少を指標
として、候補物質を選別することができる。

【０１２８】また、例えば高脂肪食負荷マウス、C57BL/
Ksj-db/db JclマウスもしくはKKAy/Ta Jclマウスから単
離・調製した初代筋肉培養細胞、L6筋筒細胞などを用い
て糖代謝異常疾患の改善剤または治療薬の有効成分とな
る候補物質をスクリーニングする場合は、被験物質を加
えた前記細胞における配列番号：314-361で示されるい
ずれかの塩基配列を有する遺伝子またはそのホモログの
発現レベルを、溶媒のみを加えた前記細胞(対照細胞)に
おける同遺伝子またはそのホモログの発現レベルと比較
し、その発現の減少を指標として、候補物質を選別する
ことができる。

【０１２９】上記遺伝子の発現レベルの検出および定量
は、前述した細胞から調製したRNAまたはそれから転写
された相補的なポリヌクレオチドと本発明疾患マーカー
とを用いて、前記(2-1)項に記述したように、ノーザン
ブロット法、RT-PCR法などの公知の方法、およびDNAチ
ップなどを利用する方法に従い実施できる。候補物質の
選別の指標である遺伝子発現の抑制の程度(有意差)とし
ては、被験物質(候補物質)の存在下で培養した細胞にお
ける特定遺伝子の発現が、被験物質(候補物質)の非存在
下で培養した対照細胞における同一遺伝子の発現と比較
して、10％、好ましくは30％、特に好ましくは50％以上
低下する程度を例示することができる。

【０１３０】上記特定遺伝子の発現レベルの検出および
定量は、該特定遺伝子の発現を制御する遺伝子領域(発
現制御領域)に、例えばルシフェラーゼ遺伝子などのマ
ーカー遺伝子をつないだ融合遺伝子を導入した細胞株を
用いて、該マーカー遺伝子由来の蛋白質の活性を測定す
ることによっても実施することができる。本発明スクリ
ーニング方法には、かかるマーカー遺伝子の発現量を指
標として標的物質を探索する方法も包含される。この意
味において、本発明でいう配列番号：1-260, 314-361で
示されるいずれかの塩基配列を有する遺伝子またはその
ホモログの概念には、該遺伝子の発現制御領域とマーカ
ー遺伝子との融合遺伝子が含まれる。

【０１３１】なお、上記マーカー遺伝子としては、発光
反応、呈色反応などを触媒する酵素の構造遺伝子が好ま
しい。具体的には、上記ルシフェラーゼ遺伝子のほか、
クロラムフェニコール・アセチルトランスフェラーゼ遺
伝子、βグルクロニダーゼ遺伝子、βガラクトシダーゼ
遺伝子、およびエクオリン遺伝子などのレポーター遺伝
子を挙げることができる。ここで遺伝子の発現制御領域
としては、例えば該遺伝子の転写開始部位上流約1kb、
好ましくは約2kbを用いることができる。融合遺伝子の
作成およびマーカー遺伝子由来の活性測定は、公知の方
法で行うことができる。

【０１３２】本発明スクリーニング法は、配列番号：1-
260, 314-361で示されるいずれかの塩基配列を有する遺
伝子の発現を有意に抑制(減少)させる物質を探索するこ
とによって、糖代謝異常疾患の予防、改善乃至治療薬の
有効成分となる候補化合物を提供するものである。当該
方法に従うスクリーニングの精度、正確性などを高める
ためには、上記特定遺伝子(そのホモログを含む)の2以
上、好ましくは複数個、より好ましくは上記遺伝子群の
4分の1以上、さらにより好ましくは半数以上について、
被験物質による遺伝子発現レベルを評価して、候補物質
を選別することが望ましい。このように複数個の遺伝子
について評価を行う場合には、個々の遺伝子での評価を
スコア化し、総合的に候補物質を選別することが可能で
ある。例えば、一つの被験物質に対して、上記遺伝子の
中から任意の10個の遺伝子について評価を行い、該被験
物質がそのうちの9個以上の遺伝子に関して糖代謝異常
疾患の改善薬または治療薬の有効成分となる候補化合物
であると評価される場合、該被験物質は候補化合物であ
る可能性が高いと判断できる。この場合、評価する遺伝
子数、スコアあるいは判断基準は限定されない。

【０１３３】本発明スクリーニング法により、被験物質
から選別される物質には、配列番号：1-260, 314-361で
示されるいずれかの塩基配列を有する遺伝子の遺伝子発
現抑制剤として位置づけられる物質が含まれる。これら
の物質は、配列番号：1-260,314-361で示されるいずれ
かの塩基配列を有する遺伝子の発現を抑制または減少さ
せることによって糖代謝異常疾患を緩和、抑制(改善、
治療)する薬物の有力な候補物質となる。

【０１３４】(3-2) 蛋白質の発現量を指標とするスクリ
ーニング方法 本発明は、配列番号：1-260,314-361で示されるいずれ
かの塩基配列を有する遺伝子によりコードされる蛋白
質、例えば配列番号：261-313,362-365で示されるいず
れかのアミノ酸配列を有する蛋白質の発現量を抑制する
物質をスクリーニングする方法を提供する。

【０１３５】本発明スクリーニング方法は、次の工程
(a)、(b)および(c)を含む： (a) 被験物質と配列番号：1-260,314-361で示されるい
ずれかの塩基配列を有する遺伝子によりコードされる蛋
白質またはそのホモログ、例えば配列番号：261-313,36
2-365で示されるいずれかのアミノ酸配列を有する蛋白
質またはそのホモログを発現可能な細胞または該細胞か
ら調製した細胞画分とを接触させる工程、(b) 被験物質
を接触させた細胞または細胞画分における配列番号：1-
260,314-361で示されるいずれかの塩基配列を有する遺
伝子によりコードされる蛋白質またはそのホモログ、例
えば配列番号：261-313,362-365で示されるいずれかの
アミノ酸配列を有する蛋白質またはそのホモログの発現
量を測定し、該発現量を被験物質を接触させない対照細
胞もしくは細胞画分における同一蛋白質またはそのホモ
ログの発現量と比較する工程、(c) 上記(b)の比較結果
に基づいて、当該蛋白質の発現量を減少させる被験物質
を選択する工程。

【０１３６】本発明スクリーニングに用いられる細胞
は、内在性および外来性を問わず、配列番号：1-260,31
4-361で示されるいずれかの塩基配列を有する遺伝子に
よりコードされる蛋白質、例えば配列番号：261-313,36
2-365で示されるいずれかのアミノ酸配列を有する蛋白
質を発現し得る細胞を挙げることができる。当該蛋白質
を発現し得る細胞としては、具体的には、前記(3-1)項
に記載したような肝臓由来の細胞、筋肉由来の細胞など
を用いることができる。細胞画分とは、上記細胞に由来
する各種の画分を意味し、これには、例えば、細胞膜画
分、細胞質画分、細胞核画分などが含まれる。

【０１３７】またかかる細胞としては、配列番号：1-26
0,314-361のいずれかの塩基配列を有する遺伝子により
コードされるヒト蛋白質に対応するヒト以外の生物種に
おける同族体または変異体(ホモログ)を発現し得る細
胞、例えば配列番号：261-313,362-365のいずれかで示
されるアミノ酸配列を有するヒト蛋白質のホモログを発
現し得る細胞を使用することもできる。例えばスクリー
ニング用細胞として、配列番号：1-260,314-361のいず
れかの塩基配列を有する遺伝子によってコードされるヒ
ト蛋白質に対応するマウス、ラットなどのホモログ（蛋
白質）〔例えば配列番号：261-313,362-365のいずれか
で示されるアミノ酸配列を有するヒト蛋白質に対応する
マウス、ラットなどのホモログ(蛋白質)〕を内在性に発
現しているマウス、ラットなどの肝臓もしくは筋肉由来
細胞を用いることができる。

【０１３８】実施例に示すように、糖代謝異常疾患の一
種である糖尿病に罹患した患者の肝臓乃至筋肉では配列
番号：1-260,314-361で示されるいずれかの塩基配列を
有する遺伝子の発現上昇が観察され、該遺伝子の発現産
物である蛋白質の増加がみられる。この知見から、当該
遺伝子がコードする蛋白質の発現量は、糖代謝異常疾患
に関連すると考えられる。本発明スクリーニング方法
は、当該遺伝子がコードする蛋白質の発現量が、糖代謝
異常疾患と関連することを利用するものである。即ち、
本発明スクリーニング方法は、上記蛋白質またはそのホ
モログの発現量を指標として、糖代謝異常疾患の緩和／
抑制作用を有する(糖代謝異常疾患の改善／治療効果を
発揮する)物質を探索するものである。本発明スクリー
ニング方法によれば、上記特定蛋白質の発現を抑制する
物質（正常レベルに戻す物質）を探索でき、かくして、
糖代謝異常疾患の予防、改善乃至治療薬の有効成分とな
る候補物質が提供される。

【０１３９】本発明スクリーニング方法に従う候補物質
の選別は、具体的には、被験物質(候補物質)の存在下で
培養した細胞における上記各遺伝子の発現産物(蛋白質
またはそのホモログ)のレベルを、被験物質(候補物質)
の非存在下で培養した対照細胞における同一遺伝子発現
産物のレベルと対比して、低くなることをもって、行う
ことができる。

【０１４０】上記蛋白質の発現量は、前述したように、
例えば、本発明疾患マーカーなどの抗体(例えば、配列
番号：261-313,362-365で示される各アミノ酸配列から
なる蛋白質またはそのホモログを認識する抗体)を用い
たウエスタンブロット法などの公知方法に従って定量で
きる。ウエスタンブロット法は、一次抗体として本発明
疾患マーカーを用いた後、二次抗体として¹²⁵Iなどの放
射性同位元素、蛍光物質などで標識した一次抗体に結合
する抗体を用いて標識し、これら標識物質由来のシグナ
ルを放射線測定器(BAS-1800II：富士フィルム社製な
ど)、蛍光検出器などで測定することによって実施でき
る。また、一次抗体として本発明疾患マーカーを用いた
後、ECL Plus Western Blotting Detction System (Ame
rsham Pharmacia Biotech 社製)を利用して、該プロト
コールに従って検出し、マルチバイオイメージャーSTOR
M860 (Amersham Pharmacia Biotech 社製)で測定するこ
ともできる。

【０１４１】本発明スクリーニング方法によってスクリ
ーニングされる被験物質(候補物質)は、制限されない
が、核酸(配列番号：1-260, 314-361のいずれかの塩基
配列を有する遺伝子またはそのホモログのアンチセンス
オリゴヌクレオチドを含む)、ペプチド、蛋白質、有機
化合物、無機化合物などであり、本発明スクリーニング
は、具体的にはこれらの被験物質またはこれらを含む試
料(被験試料)を上記細胞または細胞画分と接触させるこ
とにより行われる。被験試料としては、被験物質を含
む、細胞抽出液、遺伝子ライブラリーの発現産物、合成
低分子化合物、合成ペプチド、天然化合物などが挙げら
れるが、これらに制限されない。

【０１４２】本発明スクリーニング方法において、スク
リーニングの精度や正確性を高めるためには、被験物質
による遺伝子発現産物量(レベル)を前記特定蛋白質(そ
のホモログを含む)の2以上、好ましくは複数個、より好
ましくは上記蛋白質群の4分の1以上、さらにより好まし
くは上記蛋白質群の半数以上について評価し、候補物質
を選別することが望ましい。複数個の蛋白質について評
価する場合には、個々の蛋白質での評価をスコア化し、
総合的に候補物質を選別することが可能である。

【０１４３】(3-3) 蛋白質の機能(活性)を指標とするス
クリーニング方法 本発明は、また配列番号：1-260,314-361で示されるい
ずれかの塩基配列を有する遺伝子によりコードされる蛋
白質、例えば配列番号：261-313,362-365で示されるい
ずれかのアミノ酸配列を有する蛋白質の機能(活性)を抑
制する物質をスクリーニングする方法を提供する。

【０１４４】本発明スクリーニング方法は、次の工程
(a)、(b)および(c)を含む： (a) 被験物質と配列番号：1-260,314-361で示されるい
ずれかの塩基配列を有する遺伝子によりコードされる蛋
白質またはそのホモログ、例えば配列番号：261-313,36
2-365で示されるいずれかのアミノ酸配列を有する蛋白
質またはそのホモログを含む水溶液、細胞または該細胞
から調製した細胞画分とを接触させる工程、(b) 被験物
質を接触させた水溶液、細胞または細胞画分の、配列番
号：1-260,314-361で示されるいずれかの塩基配列を有
する遺伝子によりコードされる蛋白質またはそのホモロ
グ、例えば配列番号：261-313,362-365で示されるいず
れかのアミノ酸配列を有する蛋白質またはそのホモログ
に由来する機能(活性)を測定し、該機能(活性)を被験物
質を接触させない対照水溶液または対照細胞もしくは細
胞画分における同一蛋白質またはそのホモログに由来す
る機能(活性)と比較する工程、(c) 上記(b)の比較結果
に基づいて、配列番号：1-260,314-361で示されるいず
れかの塩基配列を有する遺伝子によりコードされる蛋白
質またはそのホモログ、例えば配列番号：261-313,362-
365で示されるいずれかのアミノ酸配列を有する蛋白質
またはそのホモログに由来する機能(活性)を抑制する被
験物質を選択する工程。

【０１４５】本発明スクリーニングに用いられる特定蛋
白質を含む水溶液は、配列番号：1-260,314-361で示さ
れるいずれかの塩基配列を有する遺伝子によりコードさ
れる蛋白質またはそのホモログ、例えば配列番号：261-
313,362-365で示されるいずれかのアミノ酸配列を有す
る蛋白質またはそのホモログを含むものであればよく、
特に制限されない。その具体例としては、例えば所定の
蛋白質の水溶液の他、所定の蛋白質を含む細胞溶解液、
核抽出液あるいは細胞の培養上清などを例示することが
できる。

【０１４６】また、本発明スクリーニングに用いられる
細胞は、内在性および外来性を問わず、配列番号：1-26
0,314-361で示されるいずれかの塩基配列を有する遺伝
子によりコードされる蛋白質またはそのホモログ、例え
ば配列番号：261-313,362-365で示されるいずれかのア
ミノ酸配列を有する蛋白質またはそのホモログ、を発現
し得る細胞を挙げることができる。該細胞としては、具
体的には、前記(3-1)項に示されるような肝臓由来の細
胞、筋肉由来の細胞などを用いることができる。細胞画
分とは、上記細胞に由来する各種の画分を意味し、これ
には、例えば、細胞膜画分、細胞質画分、細胞核画分な
どが含まれる。

【０１４７】前記(3-2)項に記載したように、糖代謝異
常疾患の一種である糖尿病に罹患した患者の肝臓乃至筋
肉組織では、配列番号：1-260,314-361で示されるいず
れかの塩基配列を有する遺伝子の発現上昇が観察され、
該遺伝子の発現産物である蛋白質の増加と共に、該蛋白
質の機能の亢進、活性化がみられる。この知見から、当
該蛋白質の機能(活性)は、糖代謝異常疾患に関連すると
考えられる。本発明スクリーニング方法は、当該蛋白質
の機能(活性)が、糖代謝異常疾患と関連することを利用
するものである。本発明スクリーニング方法は、上記蛋
白質またはそのホモログの機能または活性を指標とし
て、糖代謝異常疾患の緩和／抑制作用を有する(糖・脂
質代謝異常疾患の改善／治療効果を発揮する)物質を探
索するものである。本発明スクリーニング方法によれ
ば、配列番号：1-260,314-361で示されるいずれかの塩
基配列を有する遺伝子によりコードされる蛋白質、例え
ば配列番号：261-313,362-365で示されるいずれかのア
ミノ酸配列を有する蛋白質の機能または活性を抑制する
物質を探索でき、かくして、糖代謝異常疾患の予防、改
善乃至治療薬の有効成分となる候補物質が提供される。

【０１４８】上記蛋白質の機能または活性は、当該蛋白
質の公知の機能または活性に基づく適当なスクリーニン
グ系を構築することによって測定することができる。な
お、特定塩基配列によってコードされる蛋白質ならびに
当該蛋白質が有する機能、活性などは、例えばGenBank
などの公知のデータベースや文献検索用のデータベース
を用いて容易に調べることができる。

【０１４９】本発明スクリーニング方法に従う候補物質
の選別は、具体的には、例えば被験物質(候補物質)を添
加した細胞における上記各遺伝子の発現産物(蛋白質ま
たはそのホモログ)の機能(活性)が、被験物質(候補物
質)を添加しない細胞における同遺伝子発現産物の機能
(活性)に比して低下していることをもって、行うことが
できる。

【０１５０】本発明スクリーニング方法によってスクリ
ーニングされる被験物質(候補物質)は、制限されない
が、核酸、ペプチド、蛋白質(配列番号：261-313,362-3
65のいずれかに示されるアミノ酸配列を有する蛋白質に
対する抗体を含む)、有機化合物、無機化合物などであ
り、本発明スクリーニングは、具体的にはこれらの被験
物質またはこれらを含む試料(被験試料)を上記細胞また
は細胞画分と接触させることにより行われる。被験試料
としては、被験物質を含む、細胞抽出液、遺伝子ライブ
ラリーの発現産物、合成低分子化合物、合成ペプチド、
天然化合物などが挙げられるが、これらに制限されな
い。

【０１５１】前記(3-1)項乃至(3-3)項に示した本発明ス
クリーニング方法において、配列番号：1-260,314-361
のいずれかの塩基配列を有する遺伝子またはそのホモロ
グや、該遺伝子によりコードされる蛋白質またはそのホ
モログに関して、該遺伝子の発現を抑制、減少させる物
質や、該遺伝子によりコードされる蛋白質の発現量、機
能または活性を抑制、低下させる物質が、糖代謝異常疾
患の予防、改善乃至治療薬の有効成分として有用である
ことを確認する手段としては、例えば下記に示す実験な
どを挙げることができる。

【０１５２】例えば前記(3-1)項に記載したような肝臓
由来の細胞や筋肉由来の細胞に対して、配列番号：1-26
0,314-361で示されるいずれかの塩基配列を有する遺伝
子またはそのホモログのアンチセンスオリゴDNAを導入
し、肝臓由来細胞の場合は糖新生能を、また筋肉由来細
胞の場合は糖代謝機能（例えば細胞内への糖取り込み活
性、グリコーゲン合成能など）を測定する方法を挙げる
ことができる。本実験において、配列番号：1-260,314-
361で示されるいずれかの塩基配列を有する遺伝子また
はそのホモログのアンチセンスオリゴDNAを導入するこ
とによって当該遺伝子やその発現産物の発現・機能を低
下させた際に、糖新生能が低下するかまたは糖代謝機能
（活性）が上昇することにより、当該遺伝子の発現抑制
物質や機能抑制物質の有用性が確認される。

【０１５３】また上記実験としては、アンチセンスオリ
ゴDNAを導入する代わりに、配列番号：1-260,314-361で
示されるいずれかの塩基配列を有する遺伝子またはその
ホモログを前記細胞において強制発現させて、糖新生能
や糖代謝機能を測定する方法も挙げることができる。こ
の場合、配列番号：1-260,314-361で示されるいずれか
の塩基配列を有する遺伝子またはそのホモログの強制発
現によって当該遺伝子やその発現産物の発現・機能を上
昇させた際に、糖新生能が上昇するかまたは糖代謝機能
（活性）が低下することにより、当該遺伝子の発現抑制
物質や機能抑制物質の有用性が確認される。

【０１５４】また、前記実験としては、上記糖代謝機能
を測定する方法に加えて、脂質代謝機能測定（脂肪酸取
り込み活性、中性脂肪蓄積測定、β酸化活性測定など）
を併せて行う方法も含まれる。この方法によれば、治療
薬となり得る候補物質をより詳細に評価することができ
る。

【０１５５】更に、前記(3-1)項乃至(3-3)項に記載する
本発明スクリーニング方法によって選別された候補物質
は、これを例えば前述した肝臓由来細胞を用いた糖新生
能測定試験(in vitro)、前述した筋肉由来細胞を用いた
糖代謝機能(例えば細胞内への糖取り込み活性、グリコ
ーゲン合成能など)の測定試験(in vitro)や、糖代謝異
常疾患モデル動物、例えば高脂肪食負荷マウス、C57BL/
Ksj-db/dbJclマウス、KKAy/Ta Jclマウスなどを用いた
薬効試験、安全性試験、糖代謝異常疾患患者への臨床試
験などに供することができ、これらの試験を実施するこ
とによって、より実用的な糖代謝異常疾患の予防、改善
または治療薬を取得することができる。このようにして
選別された物質は、さらにその構造解析結果に基づい
て、化学的合成、生物学的合成（発酵）または遺伝子学
的操作によって、工業的に製造することができる。

【０１５６】（4）糖代謝異常疾患の予防、改善乃至治
療剤 本発明は、糖代謝異常疾患の予防、改善乃至治療剤を提
供する。特に、高脂血症、肥満症、糖尿病などの糖代謝
異常疾患の予防、改善乃至治療剤を提供する。

【０１５７】本発明は配列番号：1-260, 314-361で示さ
れるいずれかの塩基配列を有する遺伝子の発現が糖代謝
異常疾患と関連しているという新たな知見から、該遺伝
子の発現を抑制するかもしくは減少させる物質が、上記
疾患の予防、改善または治療に有効であるという考えに
基づくものである。すなわち、本発明の糖代謝異常疾患
の予防、改善乃至治療剤は、配列番号：1-260, 314-361
で示されるいずれかの塩基配列を有する遺伝子の発現を
抑制するかもしくは減少させる物質を有効成分とする。

【０１５８】また、本発明は配列番号：1-260, 314-361
で示されるいずれかの塩基配列を有する遺伝子によりコ
ードされる蛋白質、例えば配列番号：261-313,362-365
で示されるいずれかのアミノ酸配列を有する蛋白質の発
現量、機能または活性が糖代謝異常疾患と関連している
という新たな知見から、該蛋白質の発現量、機能または
活性を抑制するかもしくは減少させる物質が、上記疾患
の予防、改善または治療に有効であるという考えに基づ
くものである。すなわち、本発明の糖代謝異常疾患の予
防、改善乃至治療剤は、配列番号：1-260, 314-361で示
されるいずれかの塩基配列によりコードされる蛋白質、
例えば配列番号：261-313,362-365で示されるいずれか
のアミノ酸配列を有する蛋白質の発現量、機能または活
性を抑制するかもしくは減少させる物質を有効成分とす
る。

【０１５９】当該糖代謝異常疾患の予防、改善乃至治療
薬の有効成分とする物質は、本発明スクリーニング法を
利用して選別されたもののみならず、この選別された物
質に関する情報に基づいて常法に従って化学的に、生化
学的にもしくは工業的に製造されたものであってもよ
い。

【０１６０】かかる特定遺伝子の発現を制御する物質や
特定遺伝子によりコードされる特定蛋白質の発現量、機
能または活性を制御する物質は、そのままもしくは自体
公知の薬学的に許容される担体(賦形剤、増量剤、結合
剤、滑沢剤などが含まれる)、慣用の添加剤などと混合
して医薬組成物として調製することができる。当該医薬
組成物は、調製する形態(錠剤、丸剤、カプセル剤、散
剤、顆粒剤、シロップ剤などの経口投与剤；注射剤、点
滴剤、外用剤、坐剤などの非経口投与剤)に応じて経口
投与または非経口投与することができる。当該医薬組成
物の投与量は、用いる有効成分の種類、投与経路、投与
対象または患者の年齢、体重、症状などによって異なり
一概に規定できないが、通常有効成分量換算で1日の投
与用量数mg-2g程度、好ましくは数十mg程度とすればよ
い。この投与量、1日1回である必要はなく、1日に数回
にわけて行ってもよい。

【０１６１】上記有効成分物質がDNAによりコードされ
るものである場合は、該DNAを遺伝子治療用ベクターに
組み込み、遺伝子治療を行うことも考えられる。更に、
上記有効成分が配列番号：1-260,314-361のいずれかに
記載の塩基配列を有する遺伝子のアンチセンスオリゴヌ
クレオチドの場合は、そのままもしくは遺伝子治療用ベ
クターにこれを組み込むことにより、遺伝子治療を行う
こともできる。これらの場合も、投与量、投与方法など
は患者の体重、年齢、症状などにより変動し、当業者で
あれば適宜選択することが可能である。

【０１６２】

【実施例】次に、本発明を実施例によりさらに具体的に
説明する。しかし、本発明はこれらの実施例になんら限
定されるものではない。

【０１６３】実施例1 DNAチップ解析 ヒト2型糖尿病患者の肝臓組織6サンプルと、ヒトの正常
な肝臓組織39サンプルとからそれぞれ調製したtotal RN
Aを用いて、DNAチップ解析を行った。また、ヒト2型糖
尿病患者の筋肉組織4サンプルと、ヒトの正常な筋肉組
織25サンプルとからそれぞれ調製したtotal RNAを用い
て、DNAチップ解析を行った。

【０１６４】DNAチップ解析は、Affymetrix社Gene Chip
Human Genome U95A, B, C, D, Eを用いて行った。具体
的には、解析は、(1) total RNAからのcDNAの調製、(2)
該cDNAからのラベル化cRNAの調製、(3) ラベル化cRNA
のフラグメント化、(4)フラグメント化cRNAとプローブ
アレイとのハイブリダイズ、(5) プローブアレイの染
色、(6) プローブアレイのスキャンおよび(7) 遺伝子発
現解析の手順で行った。

【０１６５】(1) total RNAからのcDNAの調製 2型糖尿病患者の肝臓組織6サンプル、ヒトの正常な肝臓
組織39サンプル、2型糖尿病患者の筋肉組織4サンプルお
よびヒトの正常な筋肉組織25サンプルからそれぞれ調製
した各total RNA 10μg、T7-(dT)24プライマー(Amersha
m社製) 100pmolを含む11μLの混合液を、70℃、10分間
加熱後、氷上で冷却した。冷却後、該混合液に、SuperS
cript Choice System for cDNA Synthesis (Gibco-BRL
社製)に含まれる5×First Strand cDNA Buffer 4μL、
該キットに含まれる0.1M DTT 2μLおよび該キットに含
まれる10mM dNTP Mix 1μLを添加し、42℃で2分間加熱
した。更に、該キットに含まれるSuper ScriptII RT 2
μL(400U)を添加し、42℃で1時間加熱後、氷上で冷却し
た。冷却後、DEPC処理水(ナカライテスク社製)91μL、
該キットに含まれる5×Second Strand Reaction Buffer
30μL、10mM dNTP Mix 3μL、該キットに含まれるE. c
oli DNA Ligase 1μL(10U)、該キットに含まれるE. col
i DNA Polymerase I 4μL(40U)、該キットに含まれるE.
coli RNaseH 1μL(2U)を更に添加し、16℃で2時間反応
させた。次いで、該キットに含まれるT4DNA Polymerase
2μL(10U)を加え、16℃で5分間反応させた後、0.5M ED
TA 10μLを添加した。次いで、フェノール／クロロホル
ム／イソアミルアルコール溶液(ニッポンジーン社製)16
2μLを添加して混合した。

【０１６６】得られた混合液を、予め室温、14000rpm、
30秒間遠心分離しておいたPhase Lock Gel Light (エッ
ペンドルフ社製)に移し、室温、14000rpm、2分間遠心分
離した後、145μLの水層をエッペンドルフチューブに移
した。得られた溶液に、7.5M酢酸アンモニウム溶液72.5
μLおよびエタノール362.5μLを加えて混合した後、4
℃、14000rpm、20分間遠心分離した。遠心分離後、上清
を捨て、作製したcDNAを含むDNAペレットを得た。その
後、該ペレットに80％エタノール0.5mLを添加し、4℃、
14000rpm、5分間遠心分離した後、上清を捨てた。再度
同様の操作を行った後、該ペレットを乾燥させ、DEPC処
理水12μLに溶解した。

【０１６７】以上の操作によって、ヒト2型糖尿病患者
の肝臓組織6サンプル、ヒトの正常な肝臓組織39サンプ
ル、ヒト2型糖尿病患者の筋肉組織4サンプルおよびヒト
の正常な筋肉組織25サンプルからそれぞれ調製したtota
l RNAから、cDNAを取得した。

【０１６８】(2) cDNAからのラベル化cRNAの調製 上記(1)で調製した各cDNA溶液5μLに、DEPC処理水17μ
L、BioArray High Yield RNA Transcript Labeling Kit
(ENZO社製)に含まれる10×HY Reaction Buffer4μL、
該キットに含まれる10×Biotin Labeled Ribonucleotid
es 4μL、該キットに含まれる10×DTT 4μL、該キット
に含まれる10×RNase Inhibitor Mix 4μLおよび該キッ
トに含まれる20×T7 RNA Polymerase 2μLを混合し、37
℃で5時間反応させた。反応後、反応液にDEPC処理水60
μLを加え、次いでRNeasy Mini Kitを用いて添付プロト
コールに従うことにより、調製したラベル化cRNAを精製
した。

【０１６９】(3) ラベル化cRNAのフラグメント化 上記(2)で精製した各ラベル化cRNA 20μgを含む溶液
に、5×Fragmentation Buffer(200mMトリス-酢酸 pH8.1
(Sigma社製)、 500mM酢酸カリウム(Sigma社製)、150mM
酢酸マグネシウム(Sigma社製))8μLを加えた反応液40μ
Lを、94℃で35分間加熱した後、氷中に置いた。これに
よって、ラベル化RNAをフラグメント化した。

【０１７０】(4) フラグメント化cRNAとプローブアレイ
とのハイブリダイズ 上記(3)で得た各フラグメント化cRNA 40μLに、5nM Con
trol Oligo B2(Amersham社製)4μL、100×Control cRNA
Cocktail 4μL、Herring sperm DNA(Promega社製)40μ
g、Acetylated BSA(Gibco-BRL社製)200μg、2×MES Hyb
ridization Buffer(200mM MES、2M［Na⁺]、40mM EDTA、
0.02％ Tween20 (Pierce社製)、pH6.5-6.7)200μLおよ
びDEPC処理水144μLを混合し、400μLのハイブリカクテ
ルを得た。得られた各ハイブリカクテルを99℃で5分間
加熱し、更に45℃で5分間加熱した。加熱後、室温、140
00rpm、5分間遠心分離し、ハイブリカクテル上清を得
た。

【０１７１】一方、1×MESハイブリダイゼーションバッ
ファーで満たしたHuman genome U95プローブアレイ(Aff
ymetrix社製)を、ハイブリオーブン内で、45℃、60rp
m、10分間回転させた後、1×MESハイブリダイゼーショ
ンバッファーを除去してプローブアレイを調製した。上
記で得られたハイブリカクテル上清200μLを該プローブ
アレイにそれぞれ添加し、ハイブリオーブン内で45℃、
60rpm、16時間回転させて、フラグメント化cRNAとハイ
ブリダイズしたプローブアレイを得た。

【０１７２】(5) プローブアレイの染色 上記(4)で得られたハイブリダイズ済みプローブアレイ
のそれぞれからハイブリカクテルを回収除去した後、No
n-Stringent Wash Buffer(6×SSPE(20×SSPE (ナカライ
テスク社製)を希釈)、0.01％Tween20、0.005％Antifoam
0-30(Sigma社製))で満たした。次に、Non-Stringent Wa
sh BufferおよびStringent Wash Buffer(100mM MES、0.
1M NaCl、0.01％Tween20)をセットしたGeneChip Fluidi
cs Station 400(Affymetrix社製)の所定の位置にフラグ
メント化cRNAとハイブリダイズしたプローブアレイを装
着した。その後、染色プロトコールEuKGE-WS2に従っ
て、1次染色液(10μg/mL Streptavidin Phycoerythrin
(SAPE)(MolecμLar Probe社製)、2mg/mL Acetylated BS
A、100mM MES、1M NaCl(Ambion社製)、0.05％Tween20お
よび0.005％Antifoam0-30)および2次染色液(100μg/mL
Goat IgG (Sigma社製)、3μg/mL Biotinylated Anti-St
reptavidin antibody(Vector Laboratories社製)、2mg/
mL Acetylated BSA、100mM MES、1M NaCl、0.05％Tween
20および0.005％Antifoam0-30)により染色した。

【０１７３】(6) プローブアレイのスキャンおよび(7)
遺伝子発現解析 上記(5)で染色した各プローブアレイをHP GeneArray Sc
anner(Affymetrix社製)に供し、染色パターンを読み取
った。染色パターンをもとにGeneChip Workstation Sys
tem(Affymetrix社製)によってプローブアレイ上の遺伝
子の発現を解析した。次に、解析プロトコールに従って
Normalizationおよび遺伝子発現の比較解析を行った。

【０１７４】実施例2 ヒト2型糖尿病患者の肝臓組織と
ヒト正常肝臓組織での遺伝子発現の変動解析 実施例1で行ったDNAチップ解析による遺伝子発現の比較
解析結果から、正常肝臓組織に比べて2型糖尿病患者の
肝臓組織で3倍以上の発現増を示したプローブを選抜し
た。

【０１７５】選抜した該プローブの中から、さらにヒト
2型糖尿病患者の肝臓組織で高頻度に発現が上昇してい
るプローブを選抜した。具体的には、DNAチップ解析結
果から得られるAbs Callを指標にして、ヒト2型糖尿病
患者の肝臓組織でのAbs CallがPresentである例数が4例
以上であるプローブを選抜した。

【０１７６】各選抜したプローブについて、発現上昇の
倍率を「変動倍率」として、下記表1-表4に示す。な
お、表中の変動倍率は、Human Genome U95 Chipで解析
した正常肝臓組織の遺伝子発現量を1とした場合におけ
る2型糖尿病患者の肝臓組織での該遺伝子の発現量の増
加を比で示すものである。

【０１７７】

【表1】

【０１７８】

【表2】

【０１７９】

【表3】

【０１８０】

【表4】 表1-表4には各選抜されたプローブに対応する遺伝子の
塩基配列の配列番号を合わせて示す。また、遺伝子のう
ちの一部については、そのアミノ酸配列の配列番号も合
わせて示す。

【０１８１】表1-表4に示す結果からわかるように、配
列番号：51、52、53、54、55、56、57、58、59、60、6
1、62、63、64、65、66、67、68、69、70、71、72、7
3、74、75、76、77、78、79、80、81、82、83、84、8
5、86、87、88、89、90、91、92、93、94、95、96、9
7、98、99、100、101、102、103、104、105、106、10
7、108、109、110、111、112、113、114、115、116、11
7、118、119、120、121、122、123、124、125、126、12
7、128、129、130、131、132、133、134、135、136、13
7、138、139、140、141、142、143、144、145、146、14
7、148、149、150、151、152、153、154、155、156、15
7、158、159、160、161、162、163、198、199、200、20
1、202、203、204、205、206、207、208、209、210、21
1、212、213、214、215、216、217、218、219、220、22
1、222、223、224、225、226、227、228、229、230、23
1、232、233、234、235、236、237、238、239、240、24
1、242、243、244、245、246、247、248、249、250、25
1、252、253、254、255、256、257、258、259および260
で示される塩基配列を有する遺伝子は、正常な肝臓組織
に比べて2型糖尿病患者の肝臓組織で3倍以上、4倍未満
の発現増大を示した。

【０１８２】また、配列番号：5、6、7、8、9、10、1
1、12、13、14、15、16、17、18、19、20、21、22、2
3、24、25、26、27、28、29、30、31、32、33、34、3
5、36、37、38、39、40、41、42、43、44、45、46、4
7、48、49、50、168、169、170、171、172、173、174、
175、176、177、178、179、180、181、182、183、184、
185、186、187、188、189、190、191、192、193、194、
195、196および197で示される塩基配列を有する遺伝子
は、正常な肝臓組織に比べて2型糖尿病患者の肝臓組織
で4倍以上、ほぼ10倍までの発現増大を示した。

【０１８３】更に、配列番号：1、2、3、4、164、165、
166および167で示される塩基配列を有する遺伝子は、正
常な肝臓組織に比べて2型糖尿病患者の肝臓組織でほぼ1
0倍以上(9.7倍以上)の発現増大を示した。

【０１８４】以上の通り、配列番号：1-260で示される
塩基配列を有する遺伝子は、正常な肝臓組織に比して、
2型糖尿病患者の肝臓組織で特異的にその発現が上昇し
ており、このことから、これらは糖代謝異常疾患に関す
るマーカー遺伝子として応用可能であると考えられる。
また、これらの遺伝子を用いることによって糖代謝異常
疾患を緩和、抑制する治療薬の候補薬をスクリーニング
することが可能である。

【０１８５】実施例3 ヒト2型糖尿病患者の筋肉組織と
ヒト正常筋肉組織での遺伝子発現の変動解析 実施例1で行ったDNAチップ解析による遺伝子発現の比較
解析結果から、正常筋肉組織に比べて2型糖尿病患者の
筋肉組織で3倍以上の発現増を示したプローブを選抜し
た。

【０１８６】選抜した該プローブの中から、さらにヒト
2型糖尿病患者の筋肉組織で高頻度に発現が上昇してい
るプローブを選抜した。具体的には、DNAチップ解析結
果から得られるAbs Callを指標にして、ヒト2型糖尿病
患者の筋肉組織でのAbs CallがPresentである例数が2例
以上であるプローブを選抜した。

【０１８７】各選抜したプローブについて、発現上昇の
倍率を「変動倍率」として、下記表5に示す。なお、表
中の変動倍率は、Human Genome U95 Chipで解析した正
常筋肉組織の遺伝子発現量を1とした場合における2型糖
尿病患者の筋肉組織での該遺伝子の発現量の増加を比で
示すものである。

【０１８８】

【表5】 表5には各選抜されたプローブに対応する遺伝子の塩基
配列の配列番号を合わせて示す。また、遺伝子のうちの
一部については、そのアミノ酸配列の配列番号も合わせ
て示す。

【０１８９】表5に示す結果からわかるように、配列番
号：325、326、327、328、329、330、331、332、333、3
34、335、336、337、338、339、340、350、351、352、3
53、354、355、356、357、358、359、360および361で示
される塩基配列を有する遺伝子は、正常な筋肉組織に比
べて2型糖尿病患者の筋肉組織で3倍以上、4倍未満の発
現増大を示した。

【０１９０】また、配列番号：314、315、316、317、31
8、319、320、321、322、323、324、341、342、343、34
4、345、346、347、348および349で示される塩基配列を
有する遺伝子は、正常な筋肉組織に比べて2型糖尿病患
者の筋肉組織で4倍以上、10倍未満の発現増大を示し
た。

【０１９１】以上の通り、配列番号：314-361で示され
る塩基配列を有する遺伝子は、正常な筋肉組織に比し
て、2型糖尿病患者の筋肉組織で特異的にその発現が上
昇しており、このことから、これらは糖代謝異常疾患に
関するマーカー遺伝子として応用可能であると考えられ
る。また、これらの遺伝子を用いることによって糖代謝
異常疾患を緩和、抑制する治療薬の候補薬をスクリーニ
ングすることが可能である。

【０１９２】実施例4 配列番号：1-260で示される塩基
配列を有する遺伝子の発現を抑制する薬剤のスクリーニ
ング 高脂肪食負荷マウス、C57BL/Ksj-db/db Jclマウスもし
くはKKAy/Ta Jclマウスから、初代肝臓培養細胞を単離
・調製する。本培養液に、それぞれ100μM、10μMおよ
び1μMの濃度になるように被験物質を添加し、37℃、CO
₂濃度5％で2日間培養する。なお、対照(コントロール)
として、被験物質を添加しない本培養液についても同様
に細胞を培養する。

【０１９３】得られた各培養細胞より抽出したRNAを用
いて、実施例1に記載された方法に従って、配列番号：1
-260で示される塩基配列を有する遺伝子の発現量を調べ
る。コントロールと比べて、配列番号：1-260で示され
る塩基配列を有する遺伝子の発現量が10％、好ましくは
30％、特に好ましくは50以上低下している系について、
添加した被験物質を糖代謝異常疾患の緩和、抑制(改
善、治療)する候補物質として選択する。

【０１９４】実施例5 配列番号：314-361で示される塩
基配列を有する遺伝子の発現を抑制する薬剤のスクリー
ニング 高脂肪食負荷マウス、C57BL/Ksj-db/db Jclマウスもし
くはKKAy/Ta Jclマウスから、初代筋肉培養細胞を単離
・調製する。本培養液に、それぞれ100μM、10μMおよ
び1μMの濃度になるように被験物質を添加し、37℃、CO
₂濃度5％で2日間培養する。なお、対照(コントロール)
として、被験物質を添加しない本培養液についても同様
に細胞を培養する。

【０１９５】得られた各培養細胞より抽出したRNAを用
いて、実施例1に記載された方法に従って、配列番号：3
14-361で示される塩基配列を有する遺伝子の発現量を調
べる。コントロールと比べて、配列番号：314-361で示
される塩基配列を有する遺伝子の発現量が10％、好まし
くは30％、特に好ましくは50％以上低下している系につ
いて、添加した被験物質を糖代謝異常疾患の緩和、抑制
(改善、治療)する候補物質として選択する。

【０１９６】

【発明の効果】本発明によって、糖代謝異常疾患、例え
ば糖尿病、高脂血症、肥満症などの疾患で、発現が有意
に上昇する遺伝子(配列番号：1−260, 314-361で示され
る塩基配列を有する遺伝子)が明らかになった。これら
の遺伝子は糖代謝異常疾患の遺伝子診断に用いられるマ
ーカー遺伝子(プローブ、プライマー)として有用であ
る。これらのマーカー遺伝子によれば、糖代謝異常疾患
の原因を明らかにすることができ(診断精度の向上)、こ
れによってより適切な治療を施すことが可能となる。即
ち、本発明のマーカー遺伝子は、糖代謝異常疾患の適切
な治療のためのツールとして利用することができる。

【０１９７】また、上記遺伝子(配列番号：1-260, 314-
361)の発現上昇と糖代謝異常疾患との関連性から、該遺
伝子の発現を抑制する物質は、糖代謝異常疾患の治療薬
として有用であると考えられる。従って、本発明遺伝子
(配列番号：1-260, 314-361)によれば、その発現の抑制
を指標にすることによって、糖代謝異常疾患の治療薬と
なり得る候補薬をスクリーニングし選別することが可能
である。即ち、本発明のスクリーニング法は、糖代謝異
常疾患の治療薬の開発に有用である。

【配列表】 SEQUENCE LISTING <110> Sumitomo Pharmaceuticals <120> A marker of abnormal sugar metabolism disorders and its use <130> 43201JP <140> <141> <150> JP 2001-400709 <151> 2001-12-28 <160> 365 <170> PatentIn Ver. 2.1 <210> 1 <211> 511 <212> DNA <213> Homo sapiens <400> 1 acattcaaga taaaagattt attcacacca caaatgttat attctctttt taagtgggta 60 aaagtatttt gtttgcttct acataaattt ctattcatga gagaataaca aatattaaaa 120 tacagtgata gtttgcattt cttctataga cataaccctg aagcttttag tttacaggga 180 gtttccatga agccacaaac taaactaatt atcaaacaca ttagttattt ccagactcaa 240 atagatacac attcaaccaa taaactgaga aagaagncat ttcatgttct ctttcatttt 300 gctataaagc attttttctt ttgactaaat gcaaagtgag aaattgtatt ttttctcctt 360 ttaattgacc tcagaagatg cactatctaa ttcatgagaa taccaaattt cnnggtgtnt 420 atcttcttct tactttttgg ggtctacaac cacatatctt ctgggctgtg aaatcatggg 480 ctgttggaat tacgctgact ttgggaaagt t 511 <210> 2 <211> 373 <212> DNA <213> Homo sapiens <400> 2 ttttttttac attttttttt tcaagataag agctcagcct ttattgtggg ctcagaaggg 60 cacaagagca gaacatgcag aggactggca gcactctggc ctggcatcag caaaggaagg 120 cagcagcagg cacccatgca gctgcagcag cctcacttgc tgcacttcct gggggagcat 180 ttgcactcca tggcattgag aacctcatgg tacacaacag agccnttggt gcagtgcagg 240 gccacctcat tggggntccg tccgtntcgg agagcagcag ggagcantgg gtacttgcac 300 atcgttgatg tcaatgggag tacatggntt ttgctgggca nattttgccc tggggnaatt 360 agtgggatnt ccc 373 <210> 3 <211> 509 <212> DNA <213> Homo sapiens <400> 3 tttttcacca gtaaagatta tcatcgttta tttttgtttt taaagttgaa aacaaaaaag 60 aggagagaac agagttatgg tatgaatgta tgtaaaacta tagagaacta cagtaatatg 120 tactgtggtt attgctgtct tcaaaaaaaa aaagaaaaag aaaaacaaca acaacaacaa 180 cgaaaacaac cggtaggcaa ctcggaatct gaaggaatct tgtctgacaa ctgtgctatc 240 catgtgggct acggtgtgac agtggcggta gagaggagac tccggctggc gaccggggac 300 tggtggagtg gggtgagcgg gcacagggaa agctggggtc cccttcccct cggaccctcc 360 ccaccttccc tttccccatc caaaaggatt tcaggagagg aggccagagt ctgtgaaatg 420 actaaactat atactccatt agaaaaccaa gaaagtatgt ttgaaataga aacaaaagcc 480 taagagaaaa taaaaagtgg agaaacagt 509 <210> 4 <211> 539 <212> DNA <213> Homo sapiens <400> 4 tttttttttt tttttttttt ttttttgctt gggggaacat ggagtttatt caggggtggg 60 gacaggcggg cggctcaata acaggtgccg tccacctccc ccatgacaac aaacacattg 120 acatgggtgg gtttaccccc caagcggtcg atggtcttct gtgtgaaggc caacggcagg 180 gcctcgtggc ccaccatgca ggaaaaggtg tccccctttt ttcantcctc ggttgccacg 240 cccagtatgc tggtcacaac aaaggtggtg gtgccctggc tgggctcctg ccgggatgcc 300 caaatcaggt acttttcgcg gggcaactcc tgtgacccct gcagccagcg aaccaacacg 360 tccttggggc tgaagccgcg tgccaggcac gtcaacgtca ccagctcgtt cagggccaac 420 tcctccgacg gcggcggcag caggtggacc tcgggccgga atgtgtttcc ggattttgag 480 agggtggggt taacgggtct tggactcggg gangccagca tgcaagtgaa ggtcttccc 539 <210> 5 <211> 566 <212> DNA <213> Homo sapiens <400> 5 tttgtcttcc tattcacatt acaaaaggaa agggcaaggt tctgcagaac tgacgaagga 60 actaacagat actacaaaaa tattacaatt tgtgaagatt agctcaaccc tctcagcttt 120 tatgaatgga gcggggaggg gcccaggctg agtgggaagg gcatgggagt gagggggcca 180 gctagttcta tggaatagtt tgattttttt ctcttccttc cccaccaatg gtgaatgaca 240 tctttgctgt taaaaatact gttttctggg atttacagat cccctgaggg ccagccagtc 300 cccgcttctt cccagaccag aggaggaagc catagtgcat aatgatttct tacagacggc 360 ccctccccca aatgatttca cccttttcac attataaaca tgacaactgt tctagtcacg 420 tatttcaagt ttaacttctt ttcctttcca aaacactaag tcgttactat agttgcaaaa 480 tagcatcctc cctactttac catccctaat ccacagtcta gtgacaccgt cctcccaatt 540 cacatcctcc caacacacaa ttntaa 566 <210> 6 <211> 550 <212> DNA <213> Homo sapiens <400> 6 tttttgtttt aaagcaatat ttatttttca tgaagataag aggcatatta cattcgctat 60 agaaaatgct atgagaggaa aaagctgcat gttatcgata tgacaaaaaa cataaaaaac 120 tctacttatg aaagtgtttt gccctataag aacatattca ataaaaggca ttattccagg 180 tgaatgagcc atgcggaaat gtggatttat tagggtttgt tttgaaatgt aatttgtacg 240 gccagctttt tattcctttg atggctatca aatagattta ttggctacat gttagaagtg 300 caaaagataa caggtaacca agggagaagt tttaataaaa ctctcaggaa aggcaaagaa 360 aagtgagtga atatgcctgc ttacatttca gctaataaat aaaaagtgca gatagggctt 420 taactgaaaa ccttgctggt tattgcagcc tggaaggttt attgaaaact gggtagaaca 480 ctctcatttt ttatatttac agctacattg tgagctgttc aggttagagt gatgtaacgt 540 tcattttgac 550 <210> 7 <211> 437 <212> DNA <213> Homo sapiens <400> 7 tttttttgtt ttaacaaaca tgtttattag aaaagtaaaa aatattgcat aggtcttaat 60 acttgaacat caagtgtatt catgaacagt gagtatctta tcttcatgta aacagttcta 120 gatggaagac ccagatggca ctcctcccgg ggaggggttc cagcccccac cctctcagcc 180 cctcccctgc cagctcaact ctgcagtaca cgatggggga aggcttaaac gcagctgcca 240 ggtataattt ttcaagtgtc aaagatccca agtgatccct gacacccacc ccttcctact 300 cttacattca tgcgtctgta agatagctgc ctacaacagg tcagtagtga tgctccgatc 360 agaaaaacaa gatactaaac taacaacaaa cacacttggt cccttcagac cagtaagata 420 cacaaaccac ctccacg 437 <210> 8 <211> 492 <212> DNA <213> Homo sapiens <400> 8 ttttccaatc tgtaaaaaat attttcatta tgtttattat aaaaatataa atgtttccac 60 tacaaatcat tttacattag taagaggcca tctacattgt acaacataaa ctgagtaata 120 ttttgaaaag acaagtttaa agtaaacaca tattgccaat catatcacat ttatacatgg 180 cttgattgat atttagcaca gcataaactg agtgagttac cagaaataaa taatatatgt 240 aaatcaaatt taagatacaa aacagatcat atggtacata acatcatgta ggagttgtgg 300 ctttatgttt actgaaagtc aatgcagttc ttgtacaaag agaaggccgt aagcaatcta 360 gtaactctcc tcccacggtt tagaatcgta aacttatgtt tacatatgta cagggtaaga 420 attgtgtaaa gtaaatttat gagaggtcaa ggagaaaaat attaataaaa tgaagaacag 480 tatatggtgt at 492 <210> 9 <211> 788 <212> DNA <213> Homo sapiens <400> 9 tgctcttttt gctgctagac attttattct tgatgtagct gaatgtacga ctgacttttg 60 ttccactctt ccattcagaa tctttcttgg aggggctatg tggcaggaaa ttatagttct 120 cttctgttat actctcagtc agattagcac tggtattgtg gaaggtactg tggaagggcc 180 gtgaattgtc caatccagga tggctgattg tcattaatga gatggatttt gtcaatggag 240 aggaaatggc tgatgtacag taattaaatc cctgctgctt agatctgtga catatctgct 300 gatcaaacat cctatgttct ctctggtctg actccagatc ctcttctgaa agtgacacca 360 aagagtcaac ccgttcctca ccactgaatg ggtgtctgag ctcttcggca tttgcagagc 420 ttacttctag agatgaggat ggcttgtttc cgacaccagc tcctcctgtc aagccttcta 480 gactgaaact tctcctatga atgggaggtc tcctgacaac atccccaaga actcgcattg 540 aactccggtg gttcatttct gcatcgctgg ctgcatnntt cccngccccc agctgtgcct 600 acggaaggga gaagagagca tggagctcct taggacagag caggttgcag gcacttcatt 660 gatactgtcc atctccttct ccttcacgtc gccttggtca gcaagctcac tcttactatc 720 tcaaccatca gcttccatcc catggctgag aatccatcaa ggctttgcca tctcttggac 780 tggttgct 788 <210> 10 <211> 500 <212> DNA <213> Homo sapiens <400> 10 gtttgatcaa aatattttaa taaagattct ttctgacata gatacacata caaatggtcg 60 tacatagctg tcatagtctg attgacctat ttaatatata tatcattctt tacacatcca 120 aaacccgcca acagatccat cacagctccc aactcaccat ccaacctgac aaactgaatt 180 tgtattatct gcaaggagtg gaaaatagca ggactccatt tttaaaaaag attttcttga 240 ttttcatagg gcggaaaggc agtcaaacag ccatgcaaaa ctaaaactga aagctcactt 300 tgggtaaata gcttcttgtt cttccttagt tttctttctt tttaaatttt atttttttag 360 aaaaataaca aaggatttca caccataggc aaatcaaacc agtcttttaa cttaaataat 420 tctccacagt taaaataaca tatatgtaca tatatattaa aagcaattaa attagacctt 480 ttaaaaatgc acagcacagc 500 <210> 11 <211> 696 <212> DNA <213> Homo sapiens <400> 11 tttttttttg cagctagtgc ggagttttat tggctacaaa atagatgcaa aatgatgaga 60 atctgaaggc tgcagtagga aagtagagct ttaccctcat aaactcgcac tttgattaga 120 aaagtgcaat atattaagag cattatgaga agtctggtga gactgttaca gaaaaaaaaa 180 aaaagtttct gagtctgata attccaaggg tatcttttaa gaactcactc actggtgtct 240 gtgcaaggac tttccttggg ggaaaataga ttttacaaca ggcggaaact ttcattggtc 300 tcatgcgtgc ttttggattt cattcacttg acaaagaact aatcttccgt tgatggtctc 360 ctgggttatg gccttgatct ttggagttgc agacactttc atgctcgact ttgattcttc 420 ccgtgtccct tcactctctc cctccaggag ccgtcggtac gtggtgattt ccttctccag 480 gtgggttttg atgcccagca gcacttggta ttcattgttc tgccgctcca gttcatggcg 540 tagctgcgtc agttccctcc tcatagtggn gagatgatct ccttgcatgg tcctggagct 600 tngcaggagt acccgagact gggtctcgga taacatgtnt tccaaagcaa gattcgtgct 660 gtactgtgtc tgcaggtcaa tctcaggggc ctgaat 696 <210> 12 <211> 420 <212> DNA <213> Homo sapiens <400> 12 gggggctggc cgagcgccgt gcgcgcttgg gagaaggccg gaagcttacc agccgagaag 60 gaattcctag ctagcttcag agccggtgcc tccggagcca gcgtggtggc catagacaac 120 aagttcgaac aggccatgga tctggtgaag aatcatctga tgtatgctgt gagagaggag 180 gtggagatcc tgaaggagca gatccgagag ctggtggaga agaactccca gctagagcgt 240 gagaacaccc tgttgaagac cctggcaagc ccagagcagc tggagaagtt ccagtcctgt 300 ctgagccctg aagagccagc tcccgaatcc ccacaagtgc ccgaggcccc tggtggttct 360 gcggtgtaag tcgctctgtc ctcagggtgg gcagagccac taaacttgtt ttacctaggg 420 <210> 13 <211> 473 <212> DNA <213> Homo sapiens <400> 13 gcacgaggga aagggtagga agggtgggaa gggagaagca gacatagtca tttatgattt 60 gaaagttgga aatttgtacc atctgtttga gtatatgcac atttaaaaaa tatcatatag 120 taaatgcaaa catgccaagt attttataaa gattaataac agacctactc ttacctggca 180 gtttacttaa cttactgttt tgagtcctaa acttagagtt gttaatgctt atatataatc 240 taaccaaaga gttacccagt agggttttag tttttgaact tttattttct tgttgattat 300 aaatcctgat tttggaatct attgcgcaaa agaagtttca ttttggttac ttagacctaa 360 gatcacttat taaaaatcct tattttctcc aagcccanca aacgttgact tctgggcaaa 420 cctgaaaacc tgaaaatgcc actttcatgc agtttgtttg aagttaagtg gaa 473 <210> 14 <211> 497 <212> DNA <213> Homo sapiens <400> 14 tttctttttt tttttctttt tcccctttct ttttctttct ttctttcttt ttctttcttt 60 ctttctcttt ctctctctct tttttctttt tctttaaggt ggggaaagag acaaccaaga 120 gacaggaagc tgatctgcaa ggattcggag ttgtgctaaa aggactttga ttttttttcc 180 ccctttacga acgctggcaa ttgacatcac tacagacagc ctggttagag aacaaactgc 240 ctcatcccaa gtggaccccg gcagctgggg gaagccaggc aagatctggg aaggctgtgt 300 gtgggtgttt tttctacaga tctcactcct ccgccctttt tttttttttc ctttggtgtg 360 tgttttttgt tttgttttgt tttttaaaaa aattcttgct gtgttggaac tagcgagtgg 420 tggagtctct gaagcctcat cagtcaccgg gactgtcagg aatagtggtt taagaggaag 480 ctcggctggg ggactaa 497 <210> 15 <211> 396 <212> DNA <213> Homo sapiens <400> 15 tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt gctgcaaaaa 60 ggcttttact gggcaaacgg ggggagtttc aacccagggg accagtgagg ggggagggcc 120 cctcctccaa aggagcaggg ggggcatccc tgcccagggg ccttaacctg aatgcactaa 180 gggctggccc cttaaacagg ctcaggggag gtccccccac aagggttttg ggcccctccc 240 ttataaaaac cccccccctg ccatgggggc cggggccctt gctatcacat ttgccttggt 300 tgatctcagg gagggtgatc tctttcaggg aaaactgggg ggggggagat ttacccttgg 360 gagggccctt caaaaaatag gagtgggggg tgggga 396 <210> 16 <211> 213 <212> DNA <213> Homo sapiens <400> 16 tttttttttt ttgttttaac aaacatgttt attagaaaag taaaaaatat tgcataggtc 60 ttaatacttg aacatcaagt gtattcatga acagtgagta tcttatcttc atgtaaacag 120 ttctagatgg aagacccaga tggcactcct cccggggagg ggttccagcc cccaccctct 180 cagcccctcc cctgccagct caactctgca gta 213 <210> 17 <211> 1547 <212> DNA <213> Homo sapiens <400> 17 ggcacgagcc agtctccgcg cctccaccca gctcaggaac ccgcgaaccc tctcttgacc 60 actatgagcc tcccgtccag ccgcgcggcc cgtgtcccgg gtccttcggg ctccttgtgc 120 gcgctgctcg cgctgctgct cctgctgacg ccgccggggc ccctcgccag cgctggtcct 180 gtctctgctg tgctgacaga gctgcgttgc acttgtttac gcgttacgct gagagtaaac 240 cccaaaacga ttggtaaact gcaggtgttc cccgcaggcc cgcagtgctc caaggtggaa 300 gtggtagcct ccctgaagaa cgggaagcaa gtttgtctgg acccggaagc cccttttcta 360 aagaaagtca tccagaaaat tttggacagt ggaaacaaga aaaactgagt aacaaaaaag 420 accatgcatc ataaaattgc ccagtcttca gcggagcagt tttctggaga tccctggacc 480 cagtaagaat aagaaggaag ggttggtttt tttccatttt ctacatggat tccctacttt 540 gaagagtgtg ggggaaagcc tacgcttctc cctgaagttt acagctcagc taatgaagta 600 ctaatatagt atttccacta tttactgtta ttttacctga taagttattg aaccctttgg 660 caattgacca tattgtgagc aaagaatcac tggttattag tctttcaatg aatattgaat 720 tgaagataac tattgtattt ctatcataca ttccttaaag tcttaccgaa aaggctgtgg 780 atttcgtatg gaaataatgt tttattagtg tgctgttgag ggaggtatcc tgttgttctt 840 actcactctt ctcataaaat aggaaatatt ttagttctgt tttcttgggg aatatgttac 900 tctttaccct aggatgctat ttaagttgta ctgtattaga acactgggtg tgtcataccg 960 ttatctgtgc agaatatatt tccttattca gaatttctaa aaatttaagt tctgtaaggg 1020 ctaatatatt ctcttcctat ggttttagat gtttgatgtc ttcttagtat ggcataatgt 1080 catgatttac tcattaaact ttgattttgt atgctatttt ttcactatag gatgactata 1140 attctggtca ctaaatatac actttagata gatgaagaag cccaaaaaca gataaattcc 1200 tgattgctaa tttacataga aatgtattct cttggttttt taaataaaag caaaattaac 1260 aatgatctgt gctctgcaaa gttttgaaaa tatatttgaa caatttgaat ataaattcat 1320 catttagtcc tcaaaatata tacagcattg ctaagatttt cagatatcta ttgtggatct 1380 tttaaaggtt ttgaccattt tgttatgagg aattatacat gtatcacatt cactatatta 1440 aaattgcact tttatttttt cctgtgtgtc atgttggttt ttggtacttg tattgtcatt 1500 tggagaaaca ataaaagatt tctaaaccaa aaaaaaaaaa aaaaaaa 1547 <210> 18 <211> 934 <212> DNA <213> Homo sapiens <400> 18 gagcgagcgc gctgcagcgc gcgcatggct agcacggctt cggagatcat cgccttcatg 60 gtctccatct caggctgggt actggtgtcc tccacgctgc ccaccgacta ctggaaggtg 120 tctaccatcg acggcacggt catcacaacc gccacctatt gggccaacct gtggaaggcg 180 tgcgttaccg actccacggg cgtctccaac tgcaaggact tcccctccat gctggcgctg 240 gacggttata tacaggcatg tagaggactt atgatcgctg ctgtcagcct gggcttcttt 300 ggttccatat ttgcgctctt tggaatgaag tgtaccaaag tcggaggctc cgataaagcc 360 aaagctaaaa ttgcttgttt ggctgggatt gtattcatac tgtcagggct gtgctcaatg 420 actggatgtt ccctatatgc aaacaaaatc acaacggaat tctttgatcc tctctttgtt 480 gagcaaaagt atgaattagg agccgctctg tttattggat gggcaggagc ctcactgtgc 540 ataattggtg gtgtcatatt ttgcttttca atatctgaca acaacaaaac acccagatac 600 acatacaacg gggccacatc tgtcatgtct tctcggacaa agtatcatgg tggagaagat 660 tttaaaacaa caaacccttc aaaacagttt gataaaaatg cttatgtcta aaagagctcg 720 ctggcaagct gcctcttgag tttgttataa aagcgaactg ttcacaaaat gatcccatca 780 aggccctccc ataattaaca ctcaaaacta tttttaaaat atgcatttga agcatctgtt 840 gattgtatgg atgtaagtgt tcttacatag ttagttatat actaatcatt ttctgttgtg 900 gctttctata aaaaataaac agtttattta cagg 934 <210> 19 <211> 547 <212> DNA <213> Homo sapiens <400> 19 tttttttttt tttttttttt ccatttaaac atttttataa tttgtttcat tttcaaggca 60 caaagagttt atgtcaatca ttttaatgtc taaaaataca aagttagcac tagtaacatc 120 tggtagtcta atcatttatc atgcttaaat gtaacattac aaaactacat tttaaaatct 180 gccccctaac cagatgtgaa acaacgtgga caagggtgac atgtgctaaa cccaatctcc 240 aaaaacgtat ggttgacaaa gacagctgac tgctggggta aaactgcagc agtcataatc 300 gaagagcgaa agaggccact ctattaaaga ctttgtttct tttgctagac atttttcacc 360 taatcccagg atagtttctg ttaatgcatc ttactctctt tcaaacgaat cgtccctaga 420 gcaggtgtac acattaaaaa tgagctttat agcatcaaac acataccaca accaactcta 480 caaggagggt tttctgtaag atgtgtacga ctgtccgaag aacacattct ggctgataag 540 tctcagc 547 <210> 20 <211> 891 <212> DNA <213> Homo sapiens <400> 20 ttttaacaaa catgtttatt agaaaagtaa aaaatattgc ataggtctta atacttgaac 60 atcaagtgta ttcatgaaca gtgagtatct tatcttcatg taaacagttc tagatggaag 120 acccagatgg cactcctccc ggggagtggt tccagccccc acccatctca gcccctcccc 180 tgccagctca actctgcagt acacgatggg ggaaggctta aacgcagctg ccaggtgtaa 240 tttttcaagt gtcaaagatc ccaagtgatc cctgacaccc accccttcct actcttacat 300 tcatgcgtct gtaagatagc tgcctacaac aggtcagtag tgatgctccg atcagaaaaa 360 caagatacaa aacaaacaac aaacacactt ggtcccttca gaccagtaag atacacaaac 420 cacctccacg acctccgacc tcccccctcc ctccggctgc tctgaggaga cgtgcctctt 480 ccttcaccct gggccatgct ggtgcgggac gagccagctg ctctctggat gtcacacact 540 gttaactgtc agtatcaana atagtaaggt catgctacac acacatccag ctggaagcat 600 gttagtccct aagctttgta tcatgctaac gtctgagggt atgtgtccca tgcaagcacc 660 tgaaacaatc atgagcttct gggaaaacta tcgcactcac ctagtgctgc tcagtttcta 720 caaggnatca tcttagtctg ctctagtcca ccaagatcag tcgctctgtt gaaggcattg 780 gccatcatgt gagtacatct tatgagagtg tcgggctgaa gtctctgatg ctgagcatgt 840 cagtcagact gctacagtag aagaatgtcg agaagcctgt tctggcaatt t 891 <210> 21 <211> 648 <212> DNA <213> Homo sapiens <400> 21 tgaaaactgc agcttccttc tcaccttgaa gaataatcct agaaaactca caaaatgtgt 60 gatgcttttg taggtacctg gaaacttgtc tccagtgaaa actttgatga ttatatgaaa 120 gaagtaggag tgggctttgc accaggaaag tggctggcat ggccaaacct aacatgatca 180 tcagtgtgaa tggggatgtg atcaccatta aatctgaaag tacctttaaa aatactgaga 240 tttccttcat actgggccag gaatttgacg aagnactgca gatgacagga aagtcaagag 300 caccataacc ttagatgggg gtgtcctggt acatgtgcag aaatgggatg gaaaatcaac 360 caccataaag agaaaacgag aggatgataa actggtggtg gaatgcgtca tgaaaggcgt 420 cacttccacg agagtttatg agagagcata agccaaggga cgttgacctg actgaagttc 480 gcatgaactc tacnacattc tgtnggatat attgttccaa agatattgtt gtttccatga 540 ttagcaagcc antaattttc tncccagctg atttantcca tatggtacgt tggttaataa 600 ctttttagat ttgaaaaaaa aaaangggcc cagctnttcc ctttnggg 648 <210> 22 <211> 664 <212> DNA <213> Homo sapiens <400> 22 gaagctttta tcaactttaa ttgatataat tataattggt atgcaatatg tcttacaaca 60 aatgtggata caatgacatc aaatatcaaa gaattttccc acctttccat ctttaaatga 120 cttcagctaa cttaccccaa gagaaaaatc tggcattgat ctcttggtta gcattattac 180 caatatcaac tagcactatt aaaatcaaag ttgaaatggt acattcattt gccaaaaaaa 240 aaaaaaagaa aaaaaaggct taaaggcaaa gaaggtgaat caacgtgcaa attagcatct 300 ggcccaattg caaaattcat ttcctggatg tgagggattg aaccatgcac acttgcaagc 360 aagatgaagg gcaaacagat gacatcaaat caaaattaac cccacaaaga atccagaaga 420 cctcagatgg taaaggacag aggtctacgt ctactgctgt tagtgctcag gtatccatcc 480 tgttttccct aatctcctga ttctgatcca agagtctttg agacctatgt cctaggccat 540 cctttcatct agaaatggaa accatggctg tggcaccagg catggtcaac cctgcagtga 600 ttcagctgca caaaagggta gtccagagct tagatagctg tctgatgtgg ctaggacaca 660 actg 664 <210> 23 <211> 2344 <212> DNA <213> Homo sapiens <400> 23 cctccctgac tgggaactcg cttggccgca atgacctggc tgatggtgtg aactcgggcc 60 agggcctggg catcgagatc atcgggaccc tccagctggt gctatgcgtg ctggctacta 120 ccgaccggag gcgccgtgac cttggtggct cagcccccct tgccatcggc ctctctgtag 180 cccttggaca cctcctggct attgactaca ctggctgtgg gattaaccct gctcggtcct 240 ttggctccgc ggtgatcaca cacaacttca gcaaccactg gattttctgg gtggggccat 300 tcatcggggg agccctggct gtactcatct acgacttcat cctggcccca cgcagcagtg 360 acctcacaga ccgcgtgaag gtgtggacca gcggccaggt ggaggagtat gacctggatg 420 ccgacgacat caactccagg gtggagatga agcccaaata gaaggggtct ggcccgggca 480 tccacgtagg gggcaggggc aggggcgggc ggagggaggg gaggggtgaa atccatactg 540 tagacactct gacaagctgg ccaaagtcac ttccccaaga tctgccagac ctgcatggtc 600 aagcctctta tgggggtgtt tctatctctt tctttctctt tctgtttcct ggcctcagag 660 cttcctgggg accaagattt accaattcac ccactccctt gaagttgtgg aggaggtgaa 720 agaaagggac ccacctgcta gtcgcccctc agagcatgat gggaggtgtg ccagaaagtc 780 ccccctcgcc ccaaagttgc tcaccgactc acctgcgcaa gtgcctggga ttctaccgta 840 attgctttgt gcctttgggc aggccctcct tcttttccta acatgcacct tgctcccaat 900 ggtgcttgga gggggaagag atcccaggag gtgcagtgga gggggcaagc tttgctcctt 960 cagttctgct tgctcccaag cccctgaccc gctcggactt cctgcctgac cttggaatcg 1020 tccctatatc agggcctgag tgacctcctt ctgcaaagtg gcagggaccg gcagagctct 1080 acaggcctgc agcccctaag tgcaaacaca gcatgggtcc agaagacgtg gtctagacca 1140 gggctgctct ttccacttgc cctgtgttct ttccccaggg gcatgactgt cgccacacgc 1200 ctctgtgtac atgtgtgcag agcagacagg ctacaaagca gagatcgaca gacagccagg 1260 tagttggaac tttctgttcc ctctggagag gcttccctac acagggcctg ctattgcaga 1320 atgaagccat ttagagggtg aaggagaaat acccatgtta cttctctgac ttttagttgg 1380 tctttccatc tatcactgca ttatcttgct cattcttcag ttctctactc cctcttgtca 1440 gtgtagacac aggtcaccat tatgctggtg tatgtttatc aaagagcact tgagctgtct 1500 gaagcccaaa gcctgaggac agaaagaccc tgatgcaggt cagcccatgg aggcagatgc 1560 ccttcctggg cctgggggtt ttccaagccc tcagctggtc ctgaccagga tggagcaagc 1620 tcttcccttg ctcatgagct cctgatcaga ggcatttgag cagctgataa cctgcacagg 1680 cttgctgtat gacccctggc cacagccttc cctctgcatt gacctggagg ggagaggtca 1740 gccttgacct aatgaggtag ctatagttgc agcccaagga cagttcagag atcaggatca 1800 gctttgaagg ctggattcta tctacataag tcctttcaat tccaccaggg ccagagcagc 1860 tccaccactg tgcacttagc catgatggca acagaaacca agagacacaa ttacgcaggt 1920 atttagaagg agagggcaac cagaaggccc ttaactatca ccagtgcatc acatctgcag 1980 cactctcttc tctattccct agcaggaact tctagctcat ttaacagata aagaaactga 2040 ggcccacggt ttcagctaga caatgatttg ccaggcctag taaccaaggc cctgtctctg 2100 gctactccct ggaccacgag gctgattcct ctcatttcca gcttctcagt ttctgcctgg 2160 gcaatgccag gggccaggag tggggagagt tgtgatggag gggagagggg tcacacccac 2220 cccctgcctg gttctaggct gctgcacacc aaggccctgc atctgtctgc tctgcatata 2280 tgtctctttg gagttggaat ttcattatat gttaagaaaa taaaggaaaa tgacttgtaa 2340 ggtc 2344 <210> 24 <211> 726 <212> DNA <213> Homo sapiens <400> 24 tttttttttt tatggattat ttcatttcat tacactcaaa catccggctg aggcatatac 60 tttaatctct ttaataacag atgggaataa taactcaatg gcataaagag tttaagacac 120 ttgccaagga ttccacaact agaagtgaca gaggcaggat ttgaacccag agcccactct 180 gtcaatcact ttgtaagtta caaagattag gccttcccta aatagcagtc atgtgaattg 240 gtttctaggc ataggatttc ttttgcaata tcaaactctt ttattattga aagtgctctt 300 ctataattga aaattaaaat tgcatgccaa tttttttcaa atttttccta gaactcaaaa 360 ttttattata aagtaatcta ctttttcagg gtaaaaatgt ctgtttatag ttttataact 420 tctctaatga taacttaccc taaattaatt ttaaaattct tacatctttc aaaagtagtt 480 accattcaga tcacctgttt tccaattatg atgttaacat agtataagaa ttcatacccg 540 ggtaactgtt tcaaaactag agacttcaat atggttcacc acttaccagc ttttaaccaa 600 ttgcactgaa gaggtattta ctaattgggt cgggaggata tcaatttcct tcagaatgtt 660 ggcgagtctc acaggcaatt cttgtcgcaa aaatgcaaaa gaagttcttt cacatgcatt 720 gtctga 726 <210> 25 <211> 6360 <212> DNA <213> Homo sapiens <400> 25 ctgggccacg tgccccggaa gcttgctgcc tgacgctgtc ctcagcagtc ccctgtctca 60 tcgcagcaaa aggagcctat cctgtcggcc ccacatggtc aagctggtgt gtcccgctga 120 caacctgcgg gctgaagggc tcgagtgtgc caaaacgtgc cagaactatg acctggagtg 180 catgagcatg ggctctgtct ctggctgcct ctgccccccg ggcatggtcc ggcatgagaa 240 cagatgtgtg gccctggaaa ggtgtccctg cttccatcag ggcaaggagt atgcccctgg 300 agaaacagtg aagattggct gcaacacttg tgtctgtcgg gaccggaagt ggaactgcac 360 agaccatgtg tgtgatgcca cgtgctccac gatcggcatg gcccactacc tcaccttcga 420 cgggctcaaa tacctgttcc ccggggagtg ccagtacgtt ctggtgcagg attactgcgg 480 cagtaaccct gggacctttc ggatcctagt ggggaataag ggatgcagcc acccctcagt 540 gaaatgcaag aaacgggtca ccatcctggt ggagggagga gagattgagc tgtttgacgg 600 ggaggtgaat gtgaagaggc ccatgaagga tgagactcac tttgaggtgg tggagtctgg 660 ccggtacatc attctgctgc tgggcaaagc cctctccgtg gtctgggacc gccacctgag 720 catctccgtg gtcctgaagc agacatacca ggagaaagtg tgtggcctgt gtgggaattt 780 tgatggcatc cagaacaatg acctcaccag cagcaacctc caagtggagg aagaccctgt 840 ggactttggg aactcctgga aagtgagctc gcagtgtgct gacaccagaa aagtgcctct 900 ggactcatcc cctgccacct gccataacaa catcatgaag cagacgatgg tggattcctc 960 ctgtagaatc cttaccagtg acgtcttcca ggactgcaac aagctggtgg accccgagcc 1020 atatctggat gtctgcattt acgacacctg ctcctgtgag tccattgggg actgcgcctg 1080 cttctgcgac accattgctg cctatgccca cgtgtgtgcc cagcatggca aggtggtgac 1140 ctggaggacg gccacattgt gcccccagag ctgcgaggag aggaatctcc gggagaacgg 1200 gtatgagtgt gagtggcgct ataatagctg tgcacctgcc tgtcaagtca cgtgtcagca 1260 ccctgagcca ctggcctgcc ctgtgcagtg tgtggagggc tgccatgccc actgccctcc 1320 agggaaaatc ctggatgagc ttttgcagac ctgcgttgac cctgaagact gtccagtgtg 1380 tgaggtggct ggccggcgtt ttgcctcagg aaagaaagtc accttgaatc ccagtgaccc 1440 tgagcactgc cagatttgcc actgtgatgt tgtcaacctc acctgtgaag cctgccagga 1500 gccgggaggc ctggtggtgc ctcccacaga tgccccggtg agccccacca ctctgtatgt 1560 ggaggacatc tcggaaccgc cgttgcacga tttctactgc agcaggctac tggacctggt 1620 cttcctgctg gatggctcct ccaggctgtc cgaggctgag tttgaagtgc tgaaggcctt 1680 tgtggtggac atgatggagc ggctgcgcat ctcccagaag tgggtccgcg tggccgtggt 1740 ggagtaccac gacggctccc acgcctacat cgggctcaag gaccggaagc gaccgtcaga 1800 gctgcggcgc attgccagcc aggtgaagta tgcgggcagc caggtggcct ccaccagcga 1860 ggtcttgaaa tacacactgt tccaaatctt cagcaagatc gaccgccctg aagcctcccg 1920 catcgccctg ctcctgatgg ccagccagga gccccaacgg atgtcccgga actttgtccg 1980 ctacgtccag ggcctgaaga agaagaaggt cattgtgatc ccggtgggca ttgggcccca 2040 tgccaacctc aagcagatcc gcctcatcga gaagcaggcc cctgagaaca aggccttcgt 2100 gctgagcagt gtggatgagc tggagcagca aagggacgag atcgttagct acctctgtga 2160 ccttgcccct gaagcccctc ctcctactct gccccccgac atggcacaag tcactgtggg 2220 cccggggctc ttgggggttt cgaccctggg gcccaagagg aactccatgg ttctggatgt 2280 ggcgttcgtc ctggaaggat cggacaaaat tggtgaagcc gacttcaaca ggagcaagga 2340 gttcatggag gaggtgattc agcggatgga tgtgggccag gacagcatcc acgtcacggt 2400 gctgcagtac tcctacatgg tgaccgtgga gtaccccttc agcgaggcac agtccaaagg 2460 ggacatcctg cagcgggtgc gagagatccg ctaccagggc ggcaacagga ccaacactgg 2520 gctggccctg cggtacctct ctgaccacag cttcttggtc agccagggtg accgggagca 2580 ggcgcccaac ctggtctaca tggtcaccgg aaatcctgcc tctgatgaga tcaagaggct 2640 gcctggagac atccaggtgg tgcccattgg agtgggccct aatgccaacg tgcaggagct 2700 ggagaggatt ggctggccca atgcccctat cctcatccag gactttgaga cgctcccccg 2760 agaggctcct gacctggtgc tgcagaggtg ctgctccgga gaggggctgc agatccccac 2820 cctctcccca gcacctgact gcagccagcc cctggacgtg atccttctcc tggatggctc 2880 ctccagtttc ccagcttctt attttgatga aatgaagagt ttcgccaagg ctttcatttc 2940 aaaagccaat atagggcctc gtctcactca ggtgtcagtg ctgcagtatg gaagcatcac 3000 caccattgac gtgccatgga acgtggtccc ggagaaagcc catttgctga gccttgtgga 3060 cgtcatgcag cgggagggag gccccagcca aatcggggat gccttgggct ttgctgtgcg 3120 atacttgact tcagaaatgc atggtgccag gccgggagcc tcaaaggcgg tggtcatcct 3180 ggtcacggac gtctctgtgg attcagtgga tgcagcagct gatgccgcca ggtccaacag 3240 agtgacagtg ttccctattg gaattggaga tcgctacgat gcagcccagc tacggatctt 3300 ggcaggccca gcaggcgact ccaacgtggt gaagctccag cgaatcgaag acctccctac 3360 catggtcacc ttgggcaatt ccttcctcca caaactgtgc tctggatttg ttaggatttg 3420 catggatgag gatgggaatg agaagaggcc cggggacgtc tggaccttgc cagaccagtg 3480 ccacaccgtg acttgccagc cagatggcca gaccttgctg aagagtcatc gggtcaactg 3540 tgaccggggg ctgaggcctt cgtgccctaa cagccagtcc cctgttaaag tggaagagac 3600 ctgtggctgc cgctggacct gcccctgcgt gtgcacaggc agctccactc ggcacatcgt 3660 gacctttgat gggcagaatt tcaagctgac tggcagctgt tcttatgtcc tatttcaaaa 3720 caaggagcag gacctggagg tgattctcca taatggtgcc tgcagccctg gagcaaggca 3780 gggctgcatg aaatccatcg aggtgaagca cagtgccctc tccgtcgagc tgcacagtga 3840 catggaggtg acggtgaatg ggagactggt ctctgttcct tacgtgggtg ggaacatgga 3900 agtcaacgtt tatggtgcca tcatgcatga ggtcagattc aatcaccttg gtcacatctt 3960 cacattcact ccacaaaaca atgagttcca actgcagctc agccccaaga cttttgcttc 4020 aaagacgtat ggtctgtgtg ggatctgtga tgagaacgga gccaatgact tcatgctgag 4080 ggatggcaca gtcaccacag actggaaaac acttgttcag gaatggactg tgcagcggcc 4140 aggacagacg tgccagccca tcctggagga gcagtgtctt gtccccgaca gctcccactg 4200 ccaggtcctc ctcttaccac tgtttgctga atgccacaag gtcctggctc cagccacatt 4260 ctatgccatc tgccagcagg acagttcgca ccaggagcaa gtgtgtgagg tgatcgcctc 4320 ttatgcccac ctctgtcgga ccaacggggt ctgcgttgac tggaggacac ctgatttctg 4380 tgctatgtca tgcccaccat ctctggtcta caaccactgt gagcatggct gtccccggca 4440 ctgtgatggc aacgtgagct cctgtgggga ccatccctcc gaaggctgtt tctgccctcc 4500 agataaagtc atgttggaag gcagctgtgt ccctgaagag gcctgcactc agtgcattgg 4560 tgaggatgga gtccagcacc agttcctgga agcctgggtc ccggaccacc agccctgtca 4620 gatctgcaca tgcctcagcg ggcggaaggt caactgcaca acgcagccct gccccacggc 4680 caaagctccc acgtgtggcc tgtgtgaagt agcccgcctc cgccagaatg cagaccagtg 4740 ctgccccgag tatgagtgtg tgtgtgaccc agtgagctgt gacctgcccc cagtgcctca 4800 ctgtgaacgt ggcctccagc ccacactgac caaccctggc gagtgcagac ccaacttcac 4860 ctgcgcctgc aggaaggagg agtgcaaaag agtgtcccca ccctcctgcc ccccgcaccg 4920 tttgcccacc cttcggaaga cccagtgctg tgatgagtat gagtgtgcct gcaactgtgt 4980 caactccaca gtgagctgtc cccttgggta cttggcctca accgccacca atgactgtgg 5040 ctgtaccaca accacctgcc ttcccgacaa ggtgtgtgtc caccgaagca ccatctaccc 5100 tgtgggccag ttctgggagg agggctgcga tgtgtgcacc tgcaccgaca tggaggatgc 5160 cgtgatgggc ctccgcgtgg cccagtgctc ccagaagccc tgtgaggaca gctgtcggtc 5220 gggcttcact tacgttctgc atgaaggcga gtgctgtgga aggtgcctgc catctgcctg 5280 tgaggtggtg actggctcac cgcgggggga ctcccagtct tcctggaaga gtgtcggctc 5340 ccagtgggcc tccccggaga acccctgcct catcaatgag tgtgtccgag tgaaggagga 5400 ggtctttata caacaaagga acgtctcctg cccccagctg gaggtccctg tctgcccctc 5460 gggctttcag ctgagctgta agacctcagc gtgctgccca agctgtcgct gtgagcgcat 5520 ggaggcctgc atgctcaatg gcactgtcat tgggcccggg aagactgtga tgatcgatgt 5580 gtgcacgacc tgccgctgca tggtgcaggt gggggtcatc tctggattca agctggagtg 5640 caggaagacc acctgcaacc cctgccccct gggttacaag gaagaaaata acacaggtga 5700 atgttgtggg agatgtttgc ctacggcttg caccattcag ctaagaggag gacagatcat 5760 gacactgaag cgtgatgaga cgctccagga tggctgtgat actcacttct gcaaggtcaa 5820 tgagagagga gagtacttct gggagaagag ggtcacaggc tgcccaccct ttgatgaaca 5880 caagtgtctg gctgagggag gtaaaattat gaaaattcca ggcacctgct gtgacacatg 5940 tgaggagcct gagtgcaacg acatcactgc caggctgcag tatgtcaagg tgggaagctg 6000 taagtctgaa gtagaggtgg atatccacta ctgccagggc aaatgtgcca gcaaagccat 6060 gtactccatt gacatcaacg atgtgcagga ccagtgctcc tgctgctctc cgacacggac 6120 ggagcccatg caggtggccc tgcactgcac caatggctct gttgtgtacc atgaggttct 6180 caatgccatg gagtgcaaat gctcccccag gaagtgcagc aagtgaggct gctgcagctg 6240 catgggtgcc tgctgctgcc tgccttggcc tgatggccag gccagagtgc tgccagtcct 6300 ctgcatgttc tgctcttgtg cccttctgag cccacaataa aggctgagct cttatcttgc 6360 <210> 26 <211> 1524 <212> DNA <213> Homo sapiens <400> 26 gcagagcaca gcatcgtcgg gaccagactc gtctcaggcc agttgcagcc ttctcagcca 60 aacgccgacc aaggaaaact cactaccatg agaattgcag tgatttgctt ttgcctccta 120 ggcatcacct gtgccatacc agttaaacag gctgattctg gaagttctga ggaaaagcag 180 ctttacaaca aatacccaga tgctgtggcc acatggctaa accctgaccc atctcagaag 240 cagaatctcc tagccccaca gacccttcca agtaagtcca acgaaagcca tgaccacatg 300 gatgatatgg atgatgaaga tgatgatgac catgtggaca gccaggactc cattgactcg 360 aacgactctg atgatgtaga tgacactgat gattctcacc agtctgatga gtctcaccat 420 tctgatgaat ctgatgaact ggtcactgat tttcccacgg acctgccagc aaccgaagtt 480 ttcactccag ttgtccccac agtagacaca tatgatggcc gaggtgatag tgtggtttat 540 ggactgaggt caaaatctaa gaagtttcgc agacctgaca tccagtaccc tgatgctaca 600 gacgaggaca tcacctcaca catggaaagc gaggagttga atggtgcata caaggccatc 660 cccgttgccc aggacctgaa cgcgccttct gattgggaca gccgtgggaa ggacagttat 720 gaaacgagtc agctggatga ccagagtgct gaaacccaca gccacaagca gtccagatta 780 tataagcgga aagccaatga tgagagcaat gagcattccg atgtgattga tagtcaggaa 840 ctttccaaag tcagccgtga attccacagc catgaatttc acagccatga agatatgctg 900 gttgtagacc ccaaaagtaa ggaagaagat aaacacctga aatttcgtat ttctcatgaa 960 ttagatagtg catcttctga ggtcaattaa aaggagaaaa aatacaattt ctcactttgc 1020 atttagtcaa aagaaaaaat gctttatagc aaaatgaaag agaacatgaa atgcttcttt 1080 ctcagtttat tggttgaatg tgtatctatt tgagtctgga aataactaat gtgtttgata 1140 attagtttag tttgtggctt catggaaact ccctgtaaac taaaagcttc agggttatgt 1200 ctatgttcat tctatagaag aaatgcaaac tatcactgta ttttaatatt tgttattctc 1260 tcatgaatag aaatttatgt agaagcaaac aaaatacttt tacccactta aaaagagaat 1320 ataacatttt atgtcactat aatcttttgt tttttaagtt agtgtatatt ttgttgtgat 1380 tatctttttg tggtgtgaat aaatctttta tcttgaatgt aataagaatt tggtggtgtc 1440 aattgcttat ttgttttccc acggttgtcc agcaattaat aaaacataac cttttttact 1500 gcctaaaaaa aaaaaaaaaa aaaa 1524 <210> 27 <211> 807 <212> DNA <213> Homo sapiens <400> 27 ttgaaattta agctttttat tttggatata cataccacta ttactgtttt aaagacattt 60 ttatgtagtg atactttgta ttatggactc tataaagttc tatactgtaa tcaagacatt 120 tatataaagt gacactttgg gattatttgg cctcataagc tagatgccag tgaaattggc 180 atacacatca atagacatgt ttacacttcc agtgttaggg tttttgttta ttccagttgt 240 acttcctttg gcagacggct attatgtttt actttagtgc cgtattgtgg atgccagaga 300 acttgcattt gccagggaat aatctcctga gatgctatat tatgaagtag aatggtgtag 360 tctaattcaa taaagtcatc atttctttgc acttgcttga cagtttgaat ttttaccatt 420 ttataccatg tgtcttcagt agaattttgc catattatat aaccacaggc aacccaggct 480 aaatgtagaa cgagcgtcat ttctggagat acatttccaa aattgtctgg aatattttgt 540 gcttctagcg gttccttcat ggacttaagt ctttgataaa atgtgttgtc ttcttcatct 600 ggattctntc cagnttctcc ttcaaatgtg aangtgactt ctggtgcagt ttcttgtccc 660 gttgaaggta aagtacttca gctgtgcagn tcacctttaa ctttgtnttg tataaattct 720 tcancagcaa aatttaaggc gatactttat gtctcttcct ggaatatcct ccatgctggc 780 ttgtttgact ttttgcacnt naaacac 807 <210> 28 <211> 522 <212> DNA <213> Homo sapiens <400> 28 tttattctta tgaatctatt taattgctca gactgggcta gagaatacgt accatgaaat 60 acatatattt cataaggttc agttacaaaa tggattgttt caaatggcaa tttcttacac 120 taacctgatt atgaaaaaaa gaagtctgta tcatctgctt ccaagtctgt tatgtccaaa 180 tatattttaa ttatgcattt attttgctac ttttataaat attagagatt tcaccttaaa 240 ttatttttgt aactagttct agaacatgtt ttccaattat tatttttcta atggagacat 300 ataattgacc tatgtttatg catatatgtt ctctacacag tgaaactttt tttaaaaaga 360 atagtaaaga aaatgcggaa gctctggctc tccaaggcaa agtcaaaaaa aaaaaaaaaa 420 gcggggggga atgcgaggaa cattttatta cacctcctga ttttcactcc ttgagtttta 480 ttttctcccc ttgtttattt gtttaatgct agaaactgta tt 522 <210> 29 <211> 568 <212> DNA <213> Homo sapiens <400> 29 gatttaaaaa tagttactaa ctttatttgt attcgtttta aaaacagaac ttgttacagg 60 taatcacgaa gcttccaaaa aaaaattaca ttctgctttt gtcatcttga taggacaagg 120 aatgtttaga tgtccttaaa acacagggta aagttgacaa ataacaaact actacaaact 180 atggattgtc acttcaagca cactaaaatg tggaatacat gtacataaat tactgaccag 240 ttttttgcaa tacaaagagt atgcactaca gcttatatac cataaaggta acatgcccca 300 aaatataaca gaagattcac aaacaccgtt ccggagaaaa taataacttt gactcttggg 360 ttcaatttaa gatttgaagt gaaatggatt ggggaaagtt ttcnggaaac ctggaagggg 420 cacgcacatt ataggcagaa ccgtcaatcc accatcacgt gggggttgga aaagcngcca 480 ggangaatat gggcncggta acngggggta ccnccttctc tctcctcagt ccccatttgg 540 ggttaggaag ntgggggcct aaccggaa 568 <210> 30 <211> 410 <212> DNA <213> Homo sapiens <400> 30 tctttttttt ttttaacagc agcgctttta tttctactta cacaatgacg tgttgctggg 60 gactgatgtt ctcacataac agtagaaaac caaaattcat tgtcatctct ttaaagaatc 120 cagaattgca tacaaaaaaa aaaccttaca taaattaaaa ggataaatat atttacaggt 180 ataaatgcaa actacttcca actcaaggca agtaacagtc catggtgttc tagcaggaaa 240 acatcagcta agaaagaaaa ctgggtccta tggcttggac ttttccaacc ctgacagaca 300 gaccagcagg acagaaacaa ttggttcagg agcccatgcg agcctctaga gaaattccag 360 aacactcggc cctgacacat taataccctg cacagatcag agactgctgg 410 <210> 31 <211> 480 <212> DNA <213> Homo sapiens <400> 31 tttttttttt gcggttctgc aaactttttt taattttaat tttatttttt tacgatgtac 60 catgaacatc ttttccatgc acatgggtga aaatcctcta ctaaaatata gagcgccgta 120 gttgggtcaa aaggctgctg gtaacgagac tgacatctaa agcaaagtat cagcttaagg 180 ttaaagcatt gggcctggca aatacctacc agggaaagca gggccagcaa tattctcatc 240 agagaaatca gaatggaagg ccaaaggcat taaaggtatg ggatatcgtg taagcccctc 300 tggcccctac ctccacccct cactcccctg acaccccgtt gtccccttgg ggcgaatgga 360 tcctgtacat ctctttgcat ccaatgaaaa ccacccattt tctgtttttt ccttagctcc 420 tcttgagccc ttgacacatc tccacattct ctcatcatca gaatggtaac acctcgngcc 480 <210> 32 <211> 336 <212> DNA <213> Homo sapiens <400> 32 attttttttt tttttttttt tttcttaaca aaccctgttc ttgggtgggt gtgggtataa 60 tactaagttg agatgatatc atttacgggg gaaggaagaa gatgcatcca agaactggtt 120 agagtgcaag gaattgggaa ggaaagaaaa aggtgggagg gaggggagac aggaagagga 180 aaacagagga aaggcggagg aaagaagtac tccataaaga aaactcgggc aagaagaaca 240 aagaggttgg agagggaacg ggagcctctt gggagagtct tagaccttga caaaaaccag 300 gtgggcagag tgcaccaggt cagccacata cgccag 336 <210> 33 <211> 1337 <212> DNA <213> Homo sapiens <400> 33 caaaaacagc aacagaaagc aggacgtgag acttctacct gctcactcag aatcatttct 60 gcaccaacca tggccacgtt tgtggagctc agtaccaaag ccaagatgcc cattgtgggc 120 ctgggcactt ggaagtctcc tctcggcaaa gtgaaagaag cagtgaaggt ggccattgat 180 gcaggatatc ggcacattga ctgtgcctat gtctatcaga atgaacatga agtgggggaa 240 gccatccaag agaagatcca agagaaggct gtgaagcggg aggacctgtt catcgtcagc 300 aagttgtggc ccactttctt tgagagaccc cttgtgagga aagcctttga gaagaccctc 360 aaggacctga agctgagcta tctggacgtc tatcttattc actggccaca gggattcaag 420 tctggggatg accttttccc caaagatgat aaaggtaatg ccatcggtgg aaaagcaacg 480 ttcttggatg cctgggaggc catggaggag ctggtggatg aggggctggt gaaagccctt 540 ggggtctcca atttcagcca cttccagatc gagaagctct tgaacaaacc tggactgaaa 600 tataaaccag tgactaacca ggttgagtgt cacccatacc tcacgcagga gaaactgatc 660 cagtactgcc actccaaggg catcaccgtt acggcctaca gccccctggg ctctccggat 720 agaccttggg ccaagccaga agacccttcc ctgctggagg atcccaagat taaggagatt 780 gctgcaaagc acaaaaaaac cgcagcccag gttctgatcc gtttccatat ccagaggaat 840 gtgattgtca tccccaagtc tgtgacacca gcacgcattg ttgagaacat tcaggtcttt 900 gactttaaat tgagtgatga ggagatggca accatactca gcttcaacag aaactggagg 960 gcctgtaacg tgttgcaatc ctctcatttg gaagactatc ccttcgatgc agaatattga 1020 ggttgaatct cctggtgaga ttatacagga gattctcttt cttcgctgaa gtgtgactac 1080 ctccactcat gtcccatttt agccaagctt atttaagatc acagtgaact tagtcctgtt 1140 atagacgaga atcgaggtgc tgttttagac atttatttct gtatgttcaa ctaggatcag 1200 aatatcacag aaaagcatgg cttgaataag gaaatgacaa ttttttccac ttatctgatc 1260 agaacaaatg tttattaagc atcagaaact ctgccaacac tgaggatgta aagatcaata 1320 aaaaaaataa taatcat 1337 <210> 34 <211> 2102 <212> DNA <213> Homo sapiens <400> 34 cctgcgactt ctctaatgtc tgctttggct gcccggctgc tgcagcccgc gcacagctgc 60 tcccttcgcc ttcgcccttt ccacctcgcg gcagttcgaa atgaagctgt tgtcatttct 120 ggaaggaaac tggcccagca gatcaagcag gaagtgcggc aggaggtaga agagtgggtg 180 gcctcaggca acaaacggcc acacctgagt gtgatcctgg ttggcgagaa tcctgcaagt 240 cactcctatg tcctcaacaa aaccagggca gctgcagttg tgggaatcaa cagtgagaca 300 attatgaaac cagcttcaat ttcagaggaa gaattgttga atttaatcaa taaactgaat 360 aatgatgata atgtagatgg cctccttgtt cagttgcctc ttccagagca tattgatgag 420 agaaggatct gcaatgctgt ttctccagac aaggatgttg atggctttca tgtaattaat 480 gtaggacgaa tgtgtttgga tcagtattcc atgttaccgg ctactccatg gggtgtgtgg 540 gaaataatca agcgaactgg cattccaacc ctagggaaga atgtggttgt ggctggaagg 600 tcaaaaaacg ttggaatgcc cattgcaatg ttactgcaca cagatggggc gcatgaacgt 660 cccggaggtg atgccactgt tacaatatct catcgatata ctcccaaaga gcagttgaag 720 aaacatacaa ttcttgcaga tattgtaata tctgctgcag gtattccaaa tctgatcaca 780 gcagatatga tcaaggaagg agcagcagtc attgatgtgg gaataaatag agttcacgat 840 cctgtaactg ccaaacccaa gttggttgga gatgtggatt ttgaaggagt cagacaaaaa 900 gctgggtata tcactccagt tcctggaggt gttggcccca tgacagtggc aatgctaatg 960 aagaatacca ttattgctgc aaaaaaggtg ctgaggcttg aagagcgaga agtgctgaag 1020 tctaaagagc ttggggtagc cactaattaa ctactgtgtc ttctgtgtca caaacagcac 1080 tccaggccag ctcaagaagc aaagcaggcc aatagaaatg caatattttt aatttattct 1140 actgaaatgg tttaaaatga tgccttgtat ttattgaaag cttaaatggg tgggtgtttc 1200 tgcacatacc tctgcagtac ctcaccaggg agcattccag tatcatgcag ggtcctgtga 1260 tctagccagg agcagccatt aacctagtga ttaatatggg agacattacc atatggagga 1320 tggatgcttc actttgtcaa gcacctcagt tacacattcg ccttttctag gattgcattt 1380 cccaagtgct attgcaataa cagttgatac tcattttagg taccagacct tttgagttca 1440 actgatcaaa ccaaaggaaa agtgttgcta gagaaaattg gggaaaaggt gaaaaagaaa 1500 aaatggtagt aattgagcag aaaaaaatta atttatatat gtattgattg gcaaccagat 1560 ttatctaagt agaactgaat tggctaggaa aaaagaaaaa ctgcatgtta atcattttcc 1620 taagctgtcc ttttgaggct tagtcagttt attgggaaaa tgtttaggat tattccttgc 1680 tattagtact cattttatgt atgttaccct tcagtaagtt ctccccattt tagttttcta 1740 ggactgaaag gattcttttc tacattatac atgtgtgttg tcatatttgg cttttgctat 1800 atactttaac ttcattgtta aatttttgta ttgtatagtt tctttggtgt atcttaaaac 1860 ctatttttga aaaacaaagt tggcttgata atcatttggg cagcttgggt aagtacgcaa 1920 cttacttttc caccaaagaa ctgtcaccac ctgcctgctt ttctgtgatg tatgtatcct 1980 gttgactttt ccagaaattt tttaagagtt tgagttacta ttgaatttaa tcagactttc 2040 tgattaaagg gttttctttc ttttttaata aaacactctg tctggtgtgg tatgaatttc 2100 tg 2102 <210> 35 <211> 1447 <212> DNA <213> Homo sapiens <400> 35 gaggcagcag cagcaggagg aggcagacac agcatcgtcg ggaccagact cgtctcaggc 60 cagttgcagc cttctcagcc aaacgccgac caaggaaaac tcactaccat gagaattgca 120 gtgatttgct tttgcctcct aggcatcacc tgtgccatac cagttaaaca ggctgattct 180 ggaagttctg aggaaaagca gctttacaac aaatacccag atgctgtggc cacatggcta 240 aaccctgacc catctcagaa gcagaatctc ctagccccac agacccttcc aagtaagtcc 300 aacgaaagcc atgaccacat ggatgatatg gatgatgaag atgatgatga ccatgtggac 360 agccaggact ccattgactc gaacgactct gatgatgtag atgacactga tgattctcac 420 cagtctgatg agtctcacca ttctgatgaa tctgatgaac tggtcactga ttttcccacg 480 gacctgccag caaccgaagt tttcactcca gttgtcccca cagtagacac atatgatggc 540 cgaggtgata gtgtggttta tggactgagg tcaaaatcta agaagtttcg cagacctgac 600 atccagtacc ctgatgctac agacgaggac atcacctcac acatggaaag cgaggagttg 660 aatggtgcat acaaggccat ccccgttgcc caggacctga acgcgccttc tgattgggac 720 agccgtggga aggacagtta tgaaacgagt cagctggatg accagagtgc tgaaacccac 780 agccacaagc agtccagatt atataagcgg aaagccaatg atgagagcaa tgagcattcc 840 gatgtgattg atagtcagga actttccaaa gtcagccgtg aattccacag ccatgaattt 900 cacagccatg aagatatgct ggttgtagac cccaaaagta aggaagaaga taaacacctg 960 aaatttcgta tttctcatga attagatagt gcatcttctg aggtcaatta aaaggagaaa 1020 aaatacaatt tctcactttg catttagtca aaagaaaaaa tgctttatag caaaatgaaa 1080 gagaacatga aatgcttctt tctcagttta ttggttgaat gtgtatctat ttgagtctgg 1140 aaataactaa tgtgtttgat aattagttta gtttgtggct tcatggaaac tccctgtaaa 1200 ctaaaagctt cagggttatg tctatgttca ttctatagaa gaaatgcaaa ctatcactgt 1260 attttaatat ttgttattct ctcatgaata gaaatttatg tagaagcaaa caaaatactt 1320 ttacccactt aaaaagagaa tataacattt tatgtcacta taatcttttg ttttttaagt 1380 tagtgtatat tttgttgtga ttatcttttt gtggtgtgaa taaatctttt atcttgaatg 1440 taataag 1447 <210> 36 <211> 409 <212> DNA <213> Homo sapiens <400> 36 agcatttttt tttattgtgg caaaatatcc ataccagaaa gttaccattt tagtcatttg 60 aacgtgttcc gtgaacgtgg ctttaagcat attcacgttg ttgtgtaacc atccccacca 120 ttcatctcca caaccgtctc atcttcccaa acgcacactc tgtccccgtg agacactcat 180 tcccggcggc ccttcttata ctttcaaaaa tgaacctcct gccgcatatc ctggctgggc 240 aggctgggaa ggggaaaaat atgacaatag actggtggaa taatgaggac agagaacagg 300 aagtgaggaa agaagaggct tgagcatatt tcctttcaaa caattcttca acttgtttac 360 gtagatcagt gatgcgagca ttccattctt tgaagttgaa ctctctcac 409 <210> 37 <211> 587 <212> DNA <213> Homo sapiens <400> 37 tttttttttt tttttnnnat ggttttcaat gttttatttc acaaattgtt cagatttgtt 60 cataaaagat atgttacagg aacattttag aaatcaaacc agttctactg aaacaattgn 120 aacaacgtgg nccctgttca tgcaaagnac aaaaaacatt tacaataaan ctttgtncac 180 aggaagtagg aanatacatc atttttcata gaanaaagca cacacataat ctgcgggctg 240 agtgagccta cagacaatat gagaaaccng cacacgcttt ggggtncggn nggggaaaac 300 tcctcaggaa gccgacaatg ttcatcctct tggcaggaga ggcaggaacg ccgncgggtt 360 gggtacaanc atctttnttn ancacagggt aantnttggt nggaacgaag ggggcgcttn 420 ttcctccaaa caggggggtg gggtnctttg gggacnaggg attatcatnc attgnctttg 480 ttncccnnct tccttgcang anaattttcc nccctncana atttnggggg gngnnntnnn 540 gnaagccacn nccntntccc cncnggnnnt tncntcnctt tntcccc 587 <210> 38 <211> 443 <212> DNA <213> Homo sapiens <400> 38 gagacagggt ctcactttgt tgcccaagct ggagtgcagt ggtaaaatca tagttcactg 60 cagcctcaac ttccctcgct caaacaatcc tcctgcctca accacccaag tagctaggac 120 tgcaggcaca caccattatt attttttgta aggatgagat cttgctatgt ttcccaggct 180 tgtctagaac tcctgggctc aagcgaccct cccacctcag cctcccaaag tgctgggatt 240 ataggtgtaa gctaccacat ccagcccaaa aacttgtctt tagtgaaata tgtacagaaa 300 attctttgat tatattctgg agtacatcct gccaaatagt gcccagtcct ccctgaccta 360 catgatggat aaagttaggg cactgatgtt catccatcca atgcagtgaa aggtactctc 420 ttttagggtt gaaaaaaatc tct 443 <210> 39 <211> 672 <212> DNA <213> Homo sapiens <400> 39 aatataactt tttctttttt tatttaaata agtcttataa atgtgggaaa aaattatctt 60 gtgttccttt aatttcattt ttatttaata ctattttcag aatgaacaaa agattgaaaa 120 attatttaga atttttttct gtgctttttc ctgtttcaga taaaggagat gggtgagatg 180 catagggaac tcaatgcata actatataat ttgaagatta tagaagaagg gaaatagcaa 240 atggacacaa attacaaatg tgtgtgcgtg ggacgaagac atctttgaag gtcatgagtt 300 tgttagttta acatcatata tttgtaatag tgaaacctgt actcaaaata taagcagctt 360 gaaactggct ttaccaatct tgaaatttga ccacaagtgt cttatatatg cagatctaat 420 gtaaaatcca gaacttggac tccatcgtta aaattattta tgtgtaacat tcaaatgtgt 480 gcattaaata tgcttccaca gtaaaatctg aaaaactgat ttgtgattga aagctgcctt 540 tctatttact tgagtcttgt acatacatac ttttttatga gctatgaaat aaaacatttt 600 aaactgaatt tcttaacttt gacatttcaa atttcttctt ctttttcttt tctttttttt 660 ttttttttga ga 672 <210> 40 <211> 773 <212> DNA <213> Homo sapiens <400> 40 ttttctctct ctctctcctg cgttatcttt gtgctctcac tctctctcac tctctcccgc 60 gctctctctc tctctaagac aaatgcctct acctagcaga agtcagttgg gttggctagt 120 gcatggtttc caaatgttca gcagagatga actggggtag gtaattttgc aggaatttga 180 accctattgt ggaaatactg ttatttccct tagcaatcag caaaaactga gaaatttagt 240 gacttgcatc accatgacac agtatagcat ttggcaggta attgttcagc gacttaacta 300 gatgaattga ctttttagaa aaggtgattt caaattgaag aatttctgga aacaaagttc 360 agatcctgtg gtgtggctgg ccttggtttt tacagttcaa tcttgcatgc agggaaggat 420 tcatcttgca taaccactgt gctgctgctt gctaaaacca tgatgttgag atcttgctgt 480 ttctcatggg tctcctggta ccattccctc atcacttctg agtcatgagt tgggatcagt 540 gtcacctgca tgttgctgcc ccactgagcc tttccttcca acaagcgtnc gagacagcct 600 ggctgggctc ctgagcagca gggtcattcc cactcaccac gtagtatgaa gaccgcactc 660 tcttgaaaca ttcacatcaa cattgctact agtgctggtg ttaggaatgt acacacgtcc 720 acatacacac ggcagccctg gggcacagca natgacttgg tcgtcttgct agt 773 <210> 41 <211> 422 <212> DNA <213> Homo sapiens <400> 41 ttttttgttt ttgtgctttt tatgcttctt tgacttttta gtgggaattt catcagtagg 60 atctgtttgt acagatacgc atctactttt tctggagccc tctttcaagt ctggcttata 120 tcgtagttct gtatctaaga ccccagaaag tacttcctct atcttctgca ctatttcttc 180 atttggtaga ctcctggcag aggcagctgc atcacccgcc tggtttcctt caatgggtgt 240 atttgtttca ccattcagct ggccttcatt ccttccactg gaaagctcct gttgaatttc 300 ccggaattta ctgaccacga aagacctaaa aatctgctcg atgttggtcg ccatggcgtc 360 cgctccgttc tctcaactcc tcctcgctag tcctcggggg gggngggatt aatttaatta 420 ag 422 <210> 42 <211> 661 <212> DNA <213> Homo sapiens <400> 42 ntgtctgctt atgtcattcg tctggagcct ctgctacaga aggtggtaga gaagggggcc 60 attgataaag ataatgtgaa ccaggcccgc ctagagcagg tcattgccgg ggccaaccac 120 agcggggcca tccgaagcag ctgtggctta ccggggctgg ggaagggcca gcccaaacct 180 ctttcagttg ctggtgcaga tccgtgagag gaagccaagg ntgaggagga ggangctgag 240 gcacccttct gcagttaggc ctggaanggc acttctgagt ncaaggaaag gcagctttag 300 tgcagaccta gatcacagct acttttcttg tccctgtggg tcttacagat gtgtctctga 360 gtagtaaagg cttagctttg tncctgtttt gttgtttttt ggaggggaag gttagtcagg 420 cctgagtaat tcatgtaaca ttctaaaatt gtgccagcga acaccgtgaa cgactgcaat 480 gcaagcgggt cttgctggct aaaatgccag gtaaagggtt ggttggacac agcgcttagt 540 gcacgctgtc atcatggaca tcataatcag ttgtgaaaaa cacgcgaacc tatgacactt 600 cttattccac actgaatgtt naattgcatg ttcaaatgtt tactacgagc ctgctcaaaa 660 n 661 <210> 43 <211> 665 <212> DNA <213> Homo sapiens <400> 43 cttcaagaat aaaatgcacc atcagtattt ggagagtttg gggtctcaga tactgatata 60 ccatcagtgt ttacacccgt aaagccaaat tcaacagtac aatttatgtt aaacaacatc 120 acttcaagat ggctaacaat acaaatagag agaaaagtgg gggaaagctt taaaaatgtg 180 ttagtttgaa gcatatgaaa atgtacgatt aaaaactaca tcatacaaac ctgaaatcaa 240 aaatgttttg tggaacatca gttagagtta tactcacttg cactgttatt tattgcataa 300 agtctatgtg gttcatttcc ttcatattga tgaattgagg atttcaggaa aaccatggtt 360 ataaaaatga tcaatcttga aaaagtatgt acagataaat gtaaaatcac aaactaaaaa 420 atatccctac ccctggccct caacttacaa aagggaaagt ttcccatgga aagttcgttc 480 cactattgcc ctccctcccc catcccatgt ccccaatgct atctttttct gtctcgtaca 540 agtaaatgac cttgaaggga agaaacaaaa gccatcttta tgaggctccc attgtcatct 600 gtatcagttt gaaaagcatc ttggccggtg tggtggctca ctcctataat gccaacactt 660 tggga 665 <210> 44 <211> 852 <212> DNA <213> Homo sapiens <400> 44 cttgcagctg cccacctcac cctcagctct ggcctcttac tcaccctcta ccacagacat 60 ggctcagtca ctggctctga gcctccttat cctggttctg gcctttggca tccccaggac 120 ccaaggcagt gatggagggg ctcaggactg ttgcctcaag tacagccaaa ggaagattcc 180 cgccaaggtt gtccgcagct accggaagca ggaaccaagc ttaggctgct ccatcccagc 240 tatcctgttc ttgccccgca agcgctctca ggcagagcta tgtgcagacc caaaggagct 300 ctgggtgcag cagctgatgc agcatctgga caagacacca tccccacaga aaccagccca 360 gggctgcagg aaggacaggg gggcctccaa gactggcaag aaaggaaagg gctccaaagg 420 ctgcaagagg actgagcggt cacagacccc taaagggcca tagcccagtg agcagcctgg 480 agccctggag accccaccag cctcaccaac gcttgaagcc tgaacccaag atgcaagaag 540 gaggctatgc tcaggggccc tggagcagcc accccatgct ggccttgcca cactctttct 600 cctgctttaa ccaccccatc tgcattccca gctctaccct gcatggctga gctgcccaca 660 gcaggccagg tccagagaga ccgaggaggg agagtctccc agggagcatg agaggaggca 720 gcaggactgt ccccttgaag gagaatcatc aggaccctgg acctgatacg gctccccagt 780 acaccccacc tcttccttgt aaatatgatt tatacctaac tgaataaaaa gctgttctgt 840 cttcccaccc gc 852 <210> 45 <211> 518 <212> DNA <213> Homo sapiens <400> 45 ttgaattcca gcatttttat tgagcgcacc acatcgggga ggggcggcag tggtttccac 60 ggtaaccaaa gtaaggcttg tgcacttgct gagcttccag atgcgaatta gtaaaagcta 120 aattcaaaag tagaatgggc atctccaaag agtacgataa aaacattttg tatcaaactt 180 gtgattaaaa aaatacaaaa gttaaaccca caggcaaaga ggaaaatgac aatcctgaga 240 gctgccctga taggtgagcc tcgaacctcg tctaaatccg taagaaggca aaccctgggg 300 aggccagcac ccctcgggag agtgggagtg aacgcggagc ccacctggct tcatctgggc 360 aaagcttcgt agcgcctctg gcaggatgtg tgtccagtcc cccgaggggc agaggcactg 420 cggtgtggac acacgagggc tggggggcag gggcggagcc gaaccctgca gccaggcaaa 480 agcgggaaag gcctggttcc tccagcattt cccagctt 518 <210> 46 <211> 504 <212> DNA <213> Homo sapiens <400> 46 gttttttttt tttttttcaa gttttcaatt aagaataata tttgttgatg gcaccatctt 60 cctgtctttc agccttcagc atggtagagg aaaagagaaa gagtgtagac aaaaacagtt 120 gaagaacatc tgtgcttgtt ccaccttcat tttctgtttt gtgcgttgcc tgaatgaacc 180 gtgtcttcag gttggtattt cacaggcggt gctcccaagt agtctggttt tcccatttgt 240 ggagggcgag gtcatagagg ggacaggggg aggctgtctg gtcagcactg tgtatttcca 300 aagaacaagg actacccaaa actacaagcc tttgaaggac caaaggaaaa gagaaaaaac 360 cagcctctaa ccaggccatg cgctagaaat gattgagtat aaaaaagaaa attggtttct 420 gtgtatgagg gtgcatggaa aaggtcttta tctctgcaca aaacaaaata ttcaagtttc 480 agaatatccc aatggccttg ccct 504 <210> 47 <211> 1702 <212> DNA <213> Homo sapiens <400> 47 agactcaaca agagctccag caaagacttt cactgtagct tgacttgacc tgagattaac 60 tagggaatct tgagaataaa gatgagctct gaaaattgtt tcgtagcaga gaacagctct 120 ttgcatccgg agagtggaca agaaaatgat gccaccagtc cccatttctc aacacgtcat 180 gaagggtcct tccaagttcc tgtcctgtgt gctgtaatga atgtggtctt catcaccatt 240 ttaatcatag ctctcattgc cttatcagtg ggccaataca attgtccagg ccaatacaca 300 ttctcaatgc catcagacag ccatgtttct tcatgctctg aggactgggt tggctaccag 360 aggaaatgct actttatttc tactgtgaag aggagctgga cttcagccca aaatgcttgt 420 tctgaacatg gtgctactct tgctgtcatt gattctgaaa aggacatgaa ctttctaaaa 480 cgatacgcag gtagagagga acactgggtt ggactgaaaa aggaacctgg tcacccatgg 540 aagtggtcaa atggcaaaga atttaacaac tggttcaacg ttacagggtc tgacaagtgt 600 gtttttctga aaaacacaga ggtcagcagc atggaatgtg agaagaattt atactggata 660 tgtaacaaac cttacaaata ataaggaaac atgttcactt attgactatt atagaatgga 720 actcaaggaa atctgtgtca gtggatgctg ctctgtggtc cgaagtcttc catagagact 780 ttgtgaaaaa aaattttata gtgtcttggg aattttcttc caaacagaac tatggaaaaa 840 aaggaagaaa ttccaggaaa atctgcactg tgggctttta ttgccatgag ctagaagcat 900 cacaggttga ccaataacca tgcccaagaa tgagaagaat gactatgcaa cctttggatg 960 cactttatat tattttgaat ccagaaataa tgaaataact aggcgtggac ttactattta 1020 ttgctgaatg actaccaaca gtgagagccc ttcatgcatt tgcactactg gaaggagtta 1080 gatgttggta ctagatactg aatgtaaaca aaggaattat ggctggtaac ataggttttt 1140 agtctaattg aatcccttaa actcagggag catttataaa tggacaaatg cttatgaaac 1200 taagatttgt aatatttctc tctttttaga gaaatttgcc aatttacttt gttatttttc 1260 cccaaaaaga atgggatgat cgtgtattta tttttttact tcctcagctg tagacaggtc 1320 cttttcgatg gtacatattt ctttgccttt ataatctttt atacagtgtc ttacagagaa 1380 aagacataag caaagactat gaggaatatt tgcaagacat agaatagtgt tggaaaatgt 1440 gcaatatgtg atgtggcaaa tctctattag gaaatattct gtaatcttca gacctagaat 1500 aatactagtc ttataatagg tttgtgactt tcctaaatca attctattac gtgcaatact 1560 tcaatacttc atttaaaata tttttatgtg caataaaatg tatttgtttg tattttgtgt 1620 tcagtacaat tataagctgt ttttatatat gtgaaataaa agtagaataa acacaaaaaa 1680 aaaaaaaaaa aaaaaaaaaa aa 1702 <210> 48 <211> 593 <212> DNA <213> Homo sapiens <400> 48 tttaaatgtg cagtgttgaa tcatttcttc atagtgctcc cccgagttgg gactagggcc 60 tcaatttcac ttcttaaaaa aaatcatcat atatttgata tgcccagact gcatacgatt 120 ttaagcggag tacaactact attgtaaagc taatgtgaag atattattaa aaaggttttt 180 ttttccagaa atttggtgtc ttcaaattat accttcacct tgacatttga atatccagcc 240 attttgtttc ttaatggtat aaaattccat tttcaataac ttattggtgc tgaaattgtt 300 cactagctgt ggtctgacct agttaattta caaatacagg ttgaatagga cctactagag 360 cagcatttat agagtttgat ggcaaataga ttaggcagaa cttcatctaa aatattctta 420 gtaaataatg ttgacacgtt ttccatacct tgtcagtttc attcaacaat ttttaaattt 480 ttaacaaagc tcttaggatt tacacattta tatttaaaca ttgatatata gagtattgat 540 tgattgctca taagttaaat tggtaaagtt agaggacact attctaacac ctc 593 <210> 49 <211> 508 <212> DNA <213> Homo sapiens <400> 49 tttttttttt tttaggcaga atcaacccat gcttttattt tcattgcata taaaaatttc 60 atatgaaggt attgatgtac agtactatcc ccgtgggctg taagagaggc ttagaaacca 120 ctaaaagaat aatcatttgt aattctcaca cacaatttac cactctgaaa atatatccaa 180 agaaataaaa acaactcaaa tcagttaagg atgtttttgt aattatagtg tcccctttgt 240 actgtttaaa acaaaagtaa tcaaattcct ttgggccagg gctgctaaaa tctacagttt 300 gtgtcaaaaa ataaaataaa ataaaataaa ataggctcat ttttcctaga aaaagaatct 360 ttcctttcac tgaaaagcca catgattcaa gggctgggca agtactggga ggatgtttcc 420 atataatcca ttataaatgt ttcctgcttt aggggctggc cattgtacaa ggtgaaattt 480 taaaattcta aagcaatgaa agttttgc 508 <210> 50 <211> 829 <212> DNA <213> Homo sapiens <400> 50 tttttttttt ttttttttaa aaaacaatgt ctttaattcc tcatatgctg ncttggcaat 60 ccatatgcag cctaaaaggt ggttgaaaga tgtctgtgga cttctacaca aattgtttaa 120 gattattgaa tttgatacaa gaatacgtga agtgtcttct tgagtggtaa tgggcaccct 180 gtagttattt gctcagaacc actcacacac ccttcccctc cccacacaca cttttgccag 240 ttccccctgg tgaaccataa tacacacgtg ggagacagct ggcatnatct gagtcttgga 300 atagctttct tgtttgttat ctgcaaaaag ctaggtggcc tttttagtat caaatttcaa 360 tcttggcctc actggaacca tgctctacag agctttccca acagtttanc aagtaagcaa 420 aatcagcttt tgctcttcat atttcgtagg tgagactggg gcttttaaaa gaaatatttc 480 ataaaaaaag acaaaagccn taaatgagaa attagaggga ttttagttat cattnaagga 540 aaaaaacttc acaaattggn tcccatttgt tccatggggg aannaaaagt nttataaaag 600 ggaaataact tggattttta gggtttngaa gggggtccca aatctaaata ataaaagtnt 660 tttggattaa aacctccctt aaaaataaaa nacntatttt taaaaantta cntncccngg 720 gnttttttna gganttaaaa aagggngaaa gtttttnacg ntttaanaga aatgngttnt 780 ttggggtggg caaaatgnat atcccaatng anggntnttt tgggggggg 829 <210> 51 <211> 319 <212> DNA <213> Homo sapiens <400> 51 tttctctgag agcacttnag tatttattaa aatattttta gatgcacaga tacaatctga 60 caccaaaagc gatatggata tagtttccta gtatttttga taactgtact tactgggttg 120 ctaatttgct aactaactgt ataaattaaa gtagtggtag gtataaaaat tcagataggc 180 aatcgtttat aaactggcag tatttatgtt atgtagtcct gtagagattt taaggtttta 240 gatggaatga ttgattgaaa ttctataaag aaaactttgt aaccttctga gtattgattc 300 tcttgagggg agtgaaatg 319 <210> 52 <211> 634 <212> DNA <213> Homo sapiens <400> 52 gctactacta ctaaataagc ggccgctcga cctctgagga gacaaacaaa agacccttgg 60 ctacaaccac tactaatgtc ccttcctctt ctgcctcaaa gttaggaaag aaatataaac 120 actgagattg ccccagagct gcagtgggca gcctaggagt gccaagccat gacctacagc 180 cagcactcaa gggggagaga agcacatttt cagatcattg agagggaaca tggctgcaac 240 tgtaaggaaa cataggggag ccacatgacc aagcaagagt ctaccaactg accagtaagc 300 ccaagtgcca cctactggat cacatcccaa agcttcagca tcaaaaatac cttactaata 360 tactcccctc tgaaaccaga aatgagaagt cagcttcaaa taaagaccct gcacaaagcc 420 tcagcctngg tgaaacatcc gaaaataagt ctacggactg tactcaatct acactgcaat 480 tagaaggaaa cccataggtg gaaatgagaa gaaacaatgc aagaacgcag tgacttcaat 540 gggctctgtg tcatatgtcc ttcttaacag cacaccagtg cttccacaag agtgcttaac 600 ttggatggac tgtcttggat tacataatat aatt 634 <210> 53 <211> 2808 <212> DNA <213> Homo sapiens <400> 53 cggcatgaga ggccagcctg ccagggaaat ccaggaatct gcaacaaaaa cgatgacagt 60 ctgaaatact ctctggtgcc aacctccaaa ttctcgtctg tcacttcaga cccccactag 120 ttgacagagc agcagaatat caactccagt agacttgaat gtgcctctgg gcaaagaagc 180 agagctaacg aggaaaggga tttaaagagt ttttcttggg tgtttgtcaa acttttattc 240 cctgtctgtg tgcagagggg attcaacttc aattttctgc agtggctctg ggtccagccc 300 cttacttaaa gatctggaaa gcatgaagac tgggcctttt ttcctatgtc tcttgggaac 360 tgcagctgca atcccgacaa atgcaagatt attatctgat cattccaaac caactgctga 420 aacggtagca cctgacaaca ctgcaatccc cagtttatgg gctgaagctg aagaaaatga 480 aaaagaaaca gcagtatcca cagaagacga ttcccaccat aaggctgaaa aatcatcagt 540 actaaagtca aaagaggaaa gccatgaaca gtcagcagaa cagggcaaga gttctagcca 600 agagctggga ttgaaggatc aagaggacag tgatggtcac ttaagtgtga atttggagta 660 tgcaccaact gaaggtacat tggacataaa agaagatatg attgagcctc aggagaaaaa 720 actctcagag aacactgatt ttttggctcc tggtgttagt tccttcacag attctaacca 780 acaagaaagt atcacaaaga gagaggaaaa ccaagaacaa cctagaaatt attcacatca 840 tcagttgaac aggagcagta aacatagcca aggcctaagg gatcaaggaa accaagagca 900 ggatccaaat atttccaatg gagaagagga agaagaaaaa gagccaggtg aagttggtac 960 ccacaatgat aaccaagaaa gaaagacaga attgcccagg gagcatgcta acagcaagca 1020 ggaggaagac aatacccaat ctgatgatat tttggaagag tctgatcaac caactcaagt 1080 aagcaagatg caggaggatg aatttgatca gggtaaccaa gaacaagaag ataactccaa 1140 tgcagaaatg gaagaggaaa atgcatcgaa cgtcaataag cacattcaag aaactgaatg 1200 gcagagtcaa gagggtaaaa ctggcctaga agctatcagc aaccacaaag agacagaaga 1260 aaagactgtt tctgaggctc tgctcatgga acctactgat gatggtaata ccacgcccag 1320 aaatcatgga gttgatgatg atggcgatga tgatggcgat gatggcggca ctgatggccc 1380 caggcacagt gcaagtgatg actacttcat cccaagccag gcctttctgg aggccgagag 1440 agctcaatcc attgcctatc acctcaaaat tgaggagcaa agagaaaaag tacatgaaaa 1500 tgaaaatata ggtaccactg agcctggaga gcaccaagag gccaagaaag cagagaactc 1560 atcaaatgag gaggaaacgt caagtgaagg caacatgagg gtgcatgctg tggattcttg 1620 catgagcttc cagtgtaaaa gaggccacat ctgtaaggca gaccaacagg gaaaacctca 1680 ctgtgtctgc caggatccag tgacttgtcc tccaacaaaa ccccttgatc aagtttgtgg 1740 cactgacaat cagacctatg ctagttcctg tcatctattc gctactaaat gcagactgga 1800 ggggaccaaa aaggggcatc aactccagct ggattatttt ggagcctgca aatctattcc 1860 tacttgtacg gactttgaag tgattcagtt tcctctacgg atgagagact ggctcaagaa 1920 tatcctcatg cagctttatg aagccaactc tgaacatgct ggttatctaa atgagaagca 1980 gagaaataaa gtcaagaaaa tttacctgga tgaaaagagg cttttggctg gggaccatcc 2040 cattgatctt ctcttaaggg actttaagaa aaactaccac atgtatgtgt atcctgtgca 2100 ctggcagttt agtgaacttg accaacaccc tatggataga gtcttgacac attctgaact 2160 tgctcctctg cgagcatctc tggtgcccat ggaacactgc ataacccgtt tctttgagga 2220 gtgtgacccc aacaaggata agcacatcac cctgaaggag tggggccact gctttggaat 2280 taaagaagag gacatagatg aaaatctctt gttttgaacg aagattttaa agaactcaac 2340 tttccagcat cctcctctgt tctaaccact tcagaaatat atgcagctgt gatacttgta 2400 gatttatatt tagcaaaatg ttagcatgta tgacaagaca atgagagtaa ttgcttgaca 2460 acaacctatg caccaggtat ttaacattaa ctttggaaac aaaaatgtac aattaagtaa 2520 agtcaacata tgcaaaatac tgtacattgt gaacagaagt ttaattcata gtaatttcac 2580 tctctgcatt gacttatgag ataattaatg attaaactat taatgataaa aataatgcat 2640 ttgtattgtt cataatatca tgtgcacttc aagaaaatgg aatgctactc ttttgtggtt 2700 tacgtgtatt attttcaata tcttaatacc ctaataaaga gtccataaaa atccaaaaaa 2760 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2808 <210> 54 <211> 550 <212> DNA <213> Homo sapiens <400> 54 ttaatgtcaa atttgtacaa acatggtgct ctaccaggaa ggattcgagg tagataggct 60 caggccacac tttaaaaaca aacacacaaa caacaaaaaa cgggtattct agtcatcttg 120 gggtaaaagc gggtaatgaa cattcctatc cccaacacat caattgtatt ttttctgtaa 180 aactcagatt ttcctcagta tttgtgtttt tacattttat ggttaattta atggaagatg 240 aaagggcatt gcaaagttgt tcaacaacag ttacctcatt gagtgtgtcc agtagtgcag 300 gaaatgatgt cttatctaat gatttgcttc tctagaggag aaaccgagta aatgtgctcc 360 agcaagatag actttgtgtt attctatctt ttattctgct aagcccaaag attacatgtt 420 ggtgttcaaa gtgtagcaaa aaatgatgta tatttataaa tctatttata ccactatatc 480 atatgtatat atatttataa ccacttaaat tgtgagccaa gccatgtaaa agatctactt 540 tttctaaggg 550 <210> 55 <211> 607 <212> DNA <213> Homo sapiens <400> 55 ctgatcatgg cctttcaacc caacaagggc ccttccctgc tcttccacca gtaaaggctc 60 ctggcctctc atcaggatct gccccccaga gaccccccca gacactgcag ggcctggtga 120 tgctgtcctc tgtaccggaa atggcaggca ctgtcagatt tccactcttc tgcctttagg 180 aaggctgggt gcttcttgct ctgacagcca gtctggggag atgactctta cgttgcttga 240 gtcttggtgg caggctgctg tccacggggg agaagtctct gctctggact ggacagaaga 300 gagactttta ccctggggca ctcacacggc caagcttctg ccaccacttc attagctgta 360 ttctccatag tatggtgaaa tagcaggtgc gtcttctagt ttattcctcc tggggacatt 420 tcctcaaagc agttttgcgc ccccgcaaga aatggtcagc ctaagggtaa tgtacagccg 480 tgcttggaga accatggaan tacaccccta caggtgatac tgtctgtttt caataaatac 540 gagcggcgat tncaccacaa aaaaaaaaaa aaaaagcggc cgaanttatt cctttgtang 600 gtattta 607 <210> 56 <211> 409 <212> DNA <213> Homo sapiens <400> 56 gaataaatca aatctttaat tgagaacctg ttgatgatac ctgataaagc ctttcccacc 60 ccacctgtag cttgggaacc agtaggagca ctggaggggg tgcctcccac cccatccctc 120 tttcttcctc tccctgatcc cttagcggat ccagcagacc tctttctgtt tatggaggca 180 gcagggaaat caagggctgg atttggtgta ggctgtggtc tccgtcttgg cattgtggag 240 agagggctta gcaccttctg atgcccctgc ccagcactga ggtgcctggc ctcactgcag 300 tgtgctagac ttaagaggtg ttatttttta ttcggccaca agatggcaag gccagtgtgc 360 tagggaatgg taagccacaa aatgaaatag agatctgaga gctaggctg 409 <210> 57 <211> 530 <212> DNA <213> Homo sapiens <400> 57 ctgcaggaat ttggcacgag gtgaattgag acttggaggt gcttttcatg tttggagtat 60 catctctgtc tgggatctgg gctgacaaat naaaacctag agtagtgctt atgctgaaat 120 gatacttttn attttttggt tgattttttt gccttccctt caatttnaaa ctgaagcatt 180 ttaatatggg tagaaactct acaccaaata cactaaacat tttggtgctt agtggatttc 240 tttttaggta actggtactt acttccaaag actgantaca agccacactc catcatatcc 300 cttaancttc atgaaaaacc attcaagatc cccttgctgc aacactgtnc tcttntnctc 360 tactaaattc tatttccaaa attggtaata gagccagang gatccccagt acccaagcct 420 ctgcctggna caaagtggta gcacaattaa tttcagtatg ggtggagcat ggtcaagtct 480 tggngcctag naggagtagt tgcatagnac acaatcattt gntaaggtnc 530 <210> 58 <211> 334 <212> DNA <213> Homo sapiens <400> 58 cagtctgccc tgactcagcc tgcctccgtg tctgggtcgc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt gcttataact atgtctcctg gtaccaacag 120 cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt 180 tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc 240 caggctgacg acgagggtga ttactactgc atctcatata caagtagcaa ccctctcgtg 300 gttttcggcg gagggaccaa gctgaccgtc ctag 334 <210> 59 <211> 602 <212> DNA <213> Homo sapiens <400> 59 atttagaaat gtaaacattt atttaaaagt aggtagcaag ttaaaaatga atacttgcct 60 gaaatcataa aacataatca agttcttttt aaaacagtta atttttttcc tataatttac 120 tttcatcgaa agtatattat ctttgtttaa catgctagat agaagcaatt tagcaacata 180 aaatatatta gctatagtat gttcaaaaga atgagaaata taaattcaga gatgagacca 240 tcattttttg cagttaaaaa aaaatgttga ttctggtgca acatacactg attatccagg 300 ttttacattt tagggctgaa accctgagga acctgctggt gactgtttag cactgagcag 360 agttcagtgt gcatgcgctt ccagagttaa aagctaaagc agactgagaa acaaaaaacc 420 aacatctttg catttctgag ttttcacttg taatcatagg ttttcccaaa ttattagaat 480 gtctatacct tagctgtttt actagaatga tttatgctag tatagtcact tgtttagaag 540 tcggaaaaag atcatttttt ctttttagaa attactaagc tctgttgtac tacagctgat 600 cc 602 <210> 60 <211> 413 <212> DNA <213> Homo sapiens <400> 60 tataacattt aaaactactt atttttattt atatcagagt aacaaatact tatgaagtcc 60 tttgaagttc agcgcacaaa tttctcgtgt ggggcggtgg gtgtggccat gttcttgctc 120 ttccttcttt acacatttga gttgtgcctt ctgttcttaa agagattttc ctttgttcaa 180 aggatttatt cctaccattt cacaaatccg aaaataattg aggaaacagg ttacatcatt 240 ccaattttgc cttgggtttg aagagtctct catggtggca cagtcctcca gggtagctat 300 gttgttgggc tcccctacat cccagaagct cagagacttt gtcaaaggtg tgccgtccac 360 ccattgccac tgaccctcga caacctggtc tgacagtcca ataaaaaact ctc 413 <210> 61 <211> 340 <212> DNA <213> Homo sapiens <400> 61 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc 60 acctgcaccg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc 120 cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac 180 tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc 240 tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgaagcct 300 tacgattttt ggaccgagta acctggtcac cgtctcctca 340 <210> 62 <211> 739 <212> DNA <213> Homo sapiens <400> 62 caggctgctg cactcggtgt tacctcgggc tgaggcatga taatatttta ttttttaaag 60 ctgtgaggaa atgaaagtga ggctttggtt ggggcgaggc agttgtgaaa gaaattaaaa 120 taaaagaccc tttgtaaatg cagacttaga agaaatactg aatttgtgtc agaagttctc 180 cagtgtttgt gttaatcgtg tggtgataat cctgtcctcc ttttaaagcg aattctctac 240 tgaaaggtct gctctgctta aggagctaca aactgctctc aaaagaatga aatactgagt 300 tccaattcan gtgaggcaca agtgttggac tatggcacat ttagttggag tccgggggga 360 ggtcaggaat atgatcagat aatggatttt ataccttaga gcaaaatcta ttagtctctc 420 tcagtttatc aatttaaatg gctttaggct tatagggggt gtaaacttta agaatataat 480 tctcccattc aagtttacag caaacatcta gccaccttca aaaccaagaa gatacagacc 540 atcatttagc aatactaata catgantttc cctggggatg gcaggnttga gaatccctta 600 gccacaggac atacttcccc naaattacag tgaattattt ataccgngat aagcttcngg 660 gacagctgaa gcggggtgnt aacactaaac tacnctaatc ccaagngaag tctgcnaata 720 tgtaagtccc agggcagct 739 <210> 63 <211> 484 <212> DNA <213> Homo sapiens <400> 63 gactagcata gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt 60 tgcatttgga attgtgttaa atagaatgtg tgaacactgt attagtaaac ttcatcacct 120 ttctacttcc ttatagtttg aacttttcag tttttgtagt tcccaaacag ttgctcaatt 180 tagagcaaat taatttaaca cctgccaaaa aaaggctgct gttggcttat cagttgtctt 240 taaattcaaa tgctcatgtg acttttatca catcaaaaaa tatttcatta atgattcacc 300 tttagctctg aaaattaccg cgtttagtaa ttatagtggg cttataaaaa catgcaactc 360 tttttgatag ttatttgaga attttggtga aaaatattta gctgagggca gtatagaact 420 tataaaccaa tatattgata tttttaaaac atttttacat ataagtaaac tgccatcttt 480 gagc 484 <210> 64 <211> 315 <212> DNA <213> Homo sapiens <400> 64 gcacgagaat aaatcaacaa atgcaaccag tttgtgagaa aaaaaaanaa aagccgaaaa 60 aaaaaaaaaa aaacacctga atgcggaaga gctcggctcc cgtttagcat tttgtactta 120 aggaaataaa aaaccaacaa aggatctcac attttnttaa aaagtgaana ttgctgtata 180 ctatttattc aacttataat ttatgttact ccttgatctt tgtcttttgt catgacaaag 240 catttattta ataaagttat gcattcagtt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 300 cctcgngggg gggcc 315 <210> 65 <211> 646 <212> DNA <213> Homo sapiens <400> 65 tttttttttt tttttttttt tttttttttt tttttttttt ttttccccca tggccctttt 60 attggaagga aatattgggg acaattttta aaaggggcca attttcccca atttaattgg 120 gggccataaa aaaacaagca acaaaacagg gttggggatt tcagtttctc ccccttataa 180 taaaaactca cggcccccca taataaattt ttatggggct tttacggggt cctaggccca 240 ataaaacata caaaaaacat tgcccctgtt ttgggggggc ttactttcta aaaaaaaaaa 300 cccccctttt taaaaagggc ttttttgttg ggggttttct gcaaagccct gaggaaatat 360 ttggaaaagg gagcttgggg tttaccttac ccccatcatt atttaaagaa tagaggagga 420 aaaaagagga aggtttttaa gggcanacaa tgccacccct ttcaggatgg gtggggtttt 480 aaggggagat aaacacagtc tcatcaacta aggagagatt tgctgcanta aataggatgg 540 aggaatatat tctgtggatc caagcaaaag gaagcggggc gccttaaaca ctgagtgagc 600 ccangaagac atgcggcctt ttttccagtc cttgcccccc aagtaa 646 <210> 66 <211> 1902 <212> DNA <213> Homo sapiens <400> 66 cgcacgaggc ggaccctttg cttcgcactg ctcagcgtct gcacatccct acaatggcta 60 aaacagcaat ggcctacaag gaaaaaatga aggagctgtc catgctgtca ctgatctgct 120 cttgctttta cccggaacct cgcaacatca acatctatac ttacgatgat atggaagtga 180 agcaaatcaa caaacgtgcc tctggccagg cttttgagct gatcttgaag ccaccatctc 240 ctatctcaga aggcccacga actttagctt ctccaaagaa gaaagacctg tccctggagg 300 agatccagaa gaaactggag gctgcagagg aaagaagaaa gtctcaggag gcccaggtgc 360 tgaaacaatt ggcagagaag agggaacacg agcgagaagt ccttcagaag gctttggagg 420 agaacaacaa cttcagcaag atggcggagg aaaagctgat cctgaaaatg gaacaaatta 480 aggaaaaccg tgaggctaat ctagctgcta ttattgaacg tctgcaggaa aaggagaggc 540 atgctgcgga ggtgcgcagg aacaaggaac tccaggttga actgtctggc tgaagcaagg 600 gagggtctgg cacgccccac caatagtaaa tccccctgcc tatattataa tggatcatgc 660 gatatcagga tggggaatgt atgacatggt ttaaaaagaa ctcattataa aaaaaaaaaa 720 acaaaaaaaa tcaaaaatta aaaaaaatca atgcggtctc tttgcagaat gttttgcttg 780 atgtttaaaa aataccttgg atcttatttt gtaaatactt acatttttgt taaaaaatac 840 aagtattgca ttatgcaagt tatttcataa tcttacatgt cctgtaacag gcttttgatg 900 ttgtgtcttt ccactcaaat gaatttgcta ggtctgttct ttttgaagct ccccatgtct 960 aactccattc caaaagaaaa atgaggtcag tagacagtct atggtgctag aaacccacca 1020 ttgcctaatg acctagaagg ctttgttgtc tctgagcttg actaagacca tacctagatc 1080 acaggtatta tgactccaca tgaaccttca catttgttcg ctcataatct acttactgcc 1140 taaaaactac aaaaccaggc taagaaatac caccagtcat agcatttact tctgcttctc 1200 ctggattatg tgctacaaat gtgctttggc tttagaaagg gatggatgag aagacagacc 1260 tgagaccaat ctgggtagaa gcaaaaagtt gaacctttta aagtgctgaa cacaaatcca 1320 aattcgaatg gttcaagcag ccgtgaaatc gctcttcata aagtgggctt aattctctag 1380 tttaagttct tttgatggaa tgaattaatt aatgtgtcag gtggcttatt tgtggatgcc 1440 atgattgatg atgttcattt taagctctta cctatagtac aagtacatga tgctactgaa 1500 tatttttcca cttggaaact gtgagctggt tgttgcatta aaacacacat acaaacaaaa 1560 tcaaaaacac tgcggacttt cactcaagct ggtctttctt ccccagtgta aggcaatcct 1620 gcctactaac aacaccaaca acaaaacact ccatctgtga agctgacgca gttaaggggg 1680 ctaggcaggg catttgtgcc aactaagaat caccagatac ccaccataag tacctatcgc 1740 agttttgaag tcgtttctcc ccaactccca actcctgaag gttgctgcct gcatatttac 1800 tcttcattag tgctattttc ctgtatgtca ttgtgagcaa gctgtgatta ataaagaatt 1860 ggagttctgt gaactaaaaa aaaaaaaaaa aaaaaaaaaa aa 1902 <210> 67 <211> 418 <212> DNA <213> Homo sapiens <400> 67 gcaaaaaatt ccaaagaaac catattggac atgtttataa tacttactgc atctgaagtt 60 ttgcttgggt tattgcttgg attagaagaa tgtgaatttg aactatgaag agcactgtgg 120 ttgtgtgaat tttcttgtgg agagtaactg gtcccttaaa aaaataaaga acaaagtgaa 180 ttacaagtaa actgtatttc atgtttaatc taaactgttt tctatcatac tagatattat 240 tttatatctc taaacgaaca tcttacataa gcattaggaa tatatacaca gtcatacttt 300 ttatagtata taaagtatct gtgaacctac taaagatgtg gctttaaata ttatacatag 360 ttgtcatcct gatatgtcct ggaacagcag catataacaa cctttttgag agaaacaa 418 <210> 68 <211> 548 <212> DNA <213> Homo sapiens <400> 68 tttttttttt tttttttttt gaaggttaca gggaagatta aacatttatt tagaagttac 60 agtgtttgtt tttacagaga tatgttgcca cggattattg attctggaag gttttttaat 120 gctcatagtg ctgtacacat cttggtctgt tctcatgggc atcttaggaa aatgtttccc 180 gtagcaccgg atccagccat ctgtgtgggt gtctccaggc tgtgataccg tgccccttgc 240 tgttccctca tgctcgtgat gaaccatgtg cctgggatcc ttcctcttgc cagcttatct 300 gtgggcctcc tgcagcctcg cctgccactg cagaggcccc aggttaggag tctggtccgg 360 ggcaacctgt ggcgttgctt tcctgggtga ctcctgttag gtggcagctt ctttattttc 420 cctctccaac ctcaacgggt aggactcctt atgtctctcc agaattataa aacatataca 480 tttatttaca agtgcataaa tatataaata tggctataat agaaaaataa ataccaattt 540 tctctgtc 548 <210> 69 <211> 1360 <212> DNA <213> Homo sapiens <400> 69 cagcctcgca atgagctgcc acaactgctc cgacccccag gtcctttgca gctccgggca 60 gctgttcctg cagcccctct gggaccacct gaggagctgg gaggccctcc tacagtcgcc 120 cttcttcccg gtcatcttct ccatcaccac atacgtgggc ttttgcctgc ccttcgtggt 180 cctggatatc ctgtgctcct gggtgcccgc cctgcggcgc tacaagatcc accctgactt 240 ctcgccatcc gcgcagcagc tgctaccttg cctggggcag accctctacc agcatgtgat 300 gtttgtgttc cccgtgacgc tgctgcattg ggcccgcagc ccggccctcc tgccccacga 360 agctcccgag ctgctcctgc tgctgcacca catcctgttc tgcctgctac tcttcgacat 420 ggagttcttc gtgtggcacc tgctgcacca caaggtgccc tggctgtacc gcaccttcca 480 caaggtgcac caccagaact cgtcctcgtt cgcgctggca acgcagtata tgagcgtctg 540 ggaactgttt tctttgggct tcttcgacat gatgaacgtc acactgctcg ggtgccaccc 600 gctcaccacc ctgaccttcc acgtggtcaa catctggctt tccgtggagg accactccgg 660 ctacaacttc ccttggtcca ctcacagact ggtgcccttc gggtggtacg ggggtgtggt 720 gcaccacgac ctgcatcact ctcactttaa ctgcaacttc gctccgtact ttacacactg 780 ggacaaaata ctgggaacgc tgcggactgc atctgtccca gcgcggtgat gtggctgcgg 840 tgggtgcccc taagactcgg gactgctgtg cctttcacac ttgaatgaag agaaacacct 900 gagctatata tttttttaaa gcaactaact tattgcttta tgtttatcta tgaaaaccat 960 agataaaatc tgatgcattt ttgtaatctg acaaagtaat ttacatactg tttgtgtatc 1020 aatacaattt tgtgttcttg gtattcttag tctagctcac ctcaatagcc ttgaatcctg 1080 catatgaatt agacattcat cactggcata tttagaatat ctctaaaagg acttgtttgt 1140 agaataagga attttctatg tttcaaagtg ttctaaaacc tggctaaaag aatgtatttt 1200 tgtggatggt gttgacttct gactctaaaa gcaatcaaac atgtttctgc tggacagtga 1260 ccaagaatta tagtaccttc ttatattttt ttatagaact gtatatttat tttgaaagaa 1320 atgttattcg tgctttaaaa aggaaaaaaa accataaaaa 1360 <210> 70 <211> 309 <212> DNA <213> Homo sapiens <400> 70 ctctcaatag gaaagagaag taattcaaga aagaaataga aacttcaggc agaacatcca 60 ttcattcatt cattggattg tatatcattg ttgcacaatc agaattgata agcactgttc 120 ttccactcca tttagcaatt atgtcaccct tttttattgc agttggtttt tgaatgtctt 180 tcactccttt taaggataaa ctcctttatg gtgtgactgt gtcttattca tctatacttg 240 cagtgggtag atgtcaataa atgttacata cacaaataaa taaaatgttt attccatggt 300 aaatttatt 309 <210> 71 <211> 732 <212> DNA <213> Homo sapiens <400> 71 gaattccacc tggttcacaa aaaggattct ggcttttggc gagattttgg ctttggaatg 60 acttgtcagt atcgttcaga tttcctgacc attggtggat ttgacatgga agtgaaaggt 120 tggggtggag aagatgttca tctttatcga aaatacttac atggtgacct cattgtgatt 180 cggactccgg ttcctggtct tttccacctc tggcatgaaa agcgctgtgc tgatgagctg 240 acccccgagc agtaccgcat gtgcatccag tctaaagcca tgaatgaggc ctctcactcc 300 cacctgggaa tgctggtctt cagggaggaa atagagacgc atcttcataa acaggcatac 360 aggacaaaca gtgaagctgt tggttgaaat cataattaat gcgttactgt atgaaccaca 420 aaacagcact atttatttag ccttacttct acttccagat gcagtgcctc ttttggagaa 480 gacatgttta tttttcatgt tctttctgac attactttag caattcaact tgatgtgaga 540 agaaaaaaca aatgtttcaa cacaaaatct ctgttttgtg agaatactgc actatggaat 600 aattgacaaa ttgaaatctc atatttgtcc caaaagttgt tttgaagtta gttctacctg 660 gtgccntgtt ctgattgtgt gtgggattgc atggtgtcct gattgcatct aggtggaacg 720 gatggaattn ct 732 <210> 72 <211> 543 <212> DNA <213> Homo sapiens <400> 72 gcgtggtcgc ggccgaggta cttacatggg tgttttgatc tctgttcttt catactacat 60 ttgaacaggg caaaatgaac taactgccat gtaggctaag aaagaaatgc taacctgtgg 120 aaagttggtt ttgtaaaatt ccatggatct tgctggagaa gcatccaagg aacttcatgc 180 ttgatttgac cactgacagc ctccaccttg agcactattc taaggagcaa ataccttagc 240 tcccttgagc tggttttctc tgatggcact tttgagctcc taagctgcca gccttccctt 300 cttttcctgg gtgctcaggg catgcttatt agcagctggg ttggtatgga gttggcagac 360 aggatgttca acttaatgaa gaaatacagc taaggccttg ccagcaacac ctgccgtaag 420 ttactggctg agtgagggca tagaagttaa aggttactgt ttttatcctc tatccttttt 480 tcctttcctg atcaaggtgc tcttctcatt ntttcctgag aaccttagcc atcaaatgag 540 gct 543 <210> 73 <211> 3901 <212> DNA <213> Homo sapiens <400> 73 cagtttgcaa aagccagagg tgcaagaagc agcgactgca gcagcagcag cagcagcggc 60 ggtggcagca gcagcagcag cggcggcagc agcagcagca gcggaggcac cggtggcagc 120 agcagcatca ccagcaacaa caacaaaaaa aaatcctcat caaatcctca cctaagcttt 180 cagtgtatcc agatccacat cttcactcaa gccaggagag ggaaagagga aaggggggca 240 ggaaaaaaaa aaaacccaac aacttagcgg aaacttctca gagaatgctc caaaactcag 300 cagtgcttct ggtgctggtg atcagtgctt ctgcaaccca tgaggcggag cagaatgact 360 ctgtgagccc caggaaatcc cgagtggcgg ctcaaaactc agctgaagtg gttcgttgcc 420 tcaacagtgc tctacaggtc ggctgcgggg cttttgcatg cctggaaaac tccacctgtg 480 acacagatgg gatgtatgac atctgtaaat ccttcttgta cagcgctgct aaatttgaca 540 ctcagggaaa agcattcgtc aaagagagct taaaatgcat cgccaacggg gtcacctcca 600 aggtcttcct cgccattcgg aggtgctcca ctttccaaag gatgattgct gaggtgcagg 660 aagagtgcta cagcaagctg aatgtgtgca gcatcgccaa gcggaaccct gaagccatca 720 ctgaggtcgt ccagctgccc aatcacttct ccaacagata ctataacaga cttgtccgaa 780 gcctgctgga atgtgatgaa gacacagtca gcacaatcag agacagcctg atggagaaaa 840 ttgggcctaa catggccagc ctcttccaca tcctgcagac agaccactgt gcccaaacac 900 acccacgagc tgacttcaac aggagacgca ccaatgagcc gcagaagctg aaagtcctcc 960 tcaggaacct ccgaggtgag gaggactctc cctcccacat caaacgcaca tcccatgaga 1020 gtgcataacc agggagaggt tattcacaac ctcaccaaac tagtatcatt ttaggggtgt 1080 tgacacacca attttgagtg tactgtgcct ggtttgattt ttttaaagta gttcctattt 1140 tctatccccc ttaaagaaaa ttgcatgaaa ctaggcttct gtaatcaata tcccaacatt 1200 ctgcaatggc agcattccca ccaacaaaat ccatgtgatc attctgcctc tcctcaggag 1260 aaagtaccct cttttaccaa cttcctctgc catgtctttt cccctgctcc cctgagacca 1320 cccccaaaca caaaacattc atgtaactct ccagccattg taatttgaag atgtggatcc 1380 ctttagaacg gttgccccag tagagttagc tgataaggaa actttattta aatgcatgtc 1440 ttaaatgctc ataaagatgt taaatggaat tcgtgttatg aatctgtgct ggccatggac 1500 gaatatgaat gtcacatttg aattcttgat ctctaatgag ctagtgtctt atggtcttga 1560 tcctccaatg tctaattttc tttccgacac atttaccaaa ttgcttgagc ctggctgtcc 1620 aaccagactt tgagcctgca tcttcttgca tctaatgaaa aacaaaaagc taacatcttt 1680 acgtactgta actgctcaga gctttaaaag tatctttaac aattgtctta aaaccagaga 1740 atcttaaggt ctaactgtgg aatataaata gctgaaaact aatgtactgt acataaattc 1800 cagaggactc tgcttaaaca aagcagtata taataacttt attgcatata gatttagttt 1860 tgtaacttag ctttattttt cttttcctgg gaatggaata actatctcac ttccagatat 1920 ccacataaat gctccttgtg gcctttttta taactaaggg ggtagaagta gttttaattc 1980 aacatcaaaa cttaagatgg gcctgtatga gacaggaaaa accaacaggt ttatctgaag 2040 gaccccaggt aagatgttaa tctcccagcc cacctcaacc cagaggctac tcttgactta 2100 gacctatact gaaagatctc tgtcacatcc aactggaaat tccaggaacc aaaaagagca 2160 tccctatggg cttggaccac ttacagtgtg ataaggccta ctatacatta ggaagtggta 2220 gttctttact cgtccccttt catcggtgcc tggtactctg gcaaatgatg atggggtggg 2280 agactttcca ttaaatcaat caggaatgag tcaatcagcc tttaggtctt tagtccgggg 2340 gacttggggc tgagagagta taaataaccc tgggctgtcc agccttaata gacttctctt 2400 acattttcgt cctgtagcac gctgcctgcc aaagtagtcc tggcagctgg accatctctg 2460 taggatcgta aaaaaataga aaaaaagaaa aaaaaaagaa agaaagaggg aaaaagagct 2520 ggtggtttga tcatttctgc catgatgttt acaagatggc gaccaccaaa gtcaaacgac 2580 taacctatct atgaacaaca gtagtttctc agggtcactg tccttgaacc caacagtccc 2640 ttatgagcgt cactgcccac caaaggtcaa tgtcaagaga ggaagagagg gaggaggggt 2700 aggactgcag gggccactcc aaactcgctt aggtagaaac tattggtgct cgactctcac 2760 taggctaaac tcaagatttg accaaatcga gtgataggga tcctggtggg aggagagagg 2820 gcacatctcc agaaaaatga aaagcaatac aactttacca taaagccttt aaaaccagta 2880 acgtgctgct caaggaccaa gagcaattgc agcagaccca gcagcagcag cagcagcaca 2940 aacattgctg cctttgtccc cacacagcct ctaagcgtgc tgacatcaga ttgttaaggg 3000 catttttata ctcagaactg tcccatcccc aggtccccaa acttatggac actgccttag 3060 cctcttggaa atcaggtaga ccatattcta agttagactc ttcccctccc tcccacactt 3120 cccaccccca ggcaaggctg acttctctga atcagaaaag ctattaaagt ttgtgtgttg 3180 tgtccatttt gcaaacccaa ctaagccagg accccaatgc gacaagtagt tcatgagtat 3240 tcctagcaaa tttctctctt tcttcagttc agtagatttc cttttttctt ttcttttttt 3300 tttttttttt tttttggctg tgacctcttc aaaccgtggt accccccctt ttctccccac 3360 gatgatatct atatatgtat ctacaataca tatatctaca catacagaaa gaagcagttc 3420 tcacatgttg ctagtttttt gcttctcttt cccccaccct actccctcca attcccccct 3480 taaacttcca aagcttcgtc ttgtgtttgc tgcagagtga ttcgggggct gacctagacc 3540 agtttgcatg attcttctct tgtgatttgg ttgcacttta gacatttttg tgccattata 3600 tttgcattat gtatttataa tttaaatgat atttaggttt ttggctgagt actggaataa 3660 acagtgagca tatctggtat atgtcattat ttattgttaa attacatttt ttaagctcca 3720 tgtgcatata aaggttatga aacatatcat ggtaatgaca gatgcaagtt attttatttg 3780 cttatttttt ataattaaag atgccatagc ataatatgaa gcctttggtg aattccttct 3840 aagataaaaa taataataaa gtgttacgtt ttattggttt caaaaaaaaa aaaaaaaaaa 3900 a 3901 <210> 74 <211> 483 <212> DNA <213> Homo sapiens <400> 74 tttttttttc acaatttata tactttatta cagtccacag tctgctaaat aaaagcagta 60 acaagatatt tcacaaacta ttgtacagat taagtcttat gaatttaatc tcataaaaaa 120 ttaggtgcat agtcacactg gctaacctaa aaatgctatt ttatctacag cctaaaataa 180 gaggcagttc caacactaaa aattaatccc agttttnttt tttacatgtt ttacaaaaaa 240 aagtttgtgc tcttaatcaa aaagatcgag gctaattcag catgtaaaaa ataaatttta 300 caaagaaccc agganaatat ttttcaaaca cacttttatt ttctttttnt ccttcctcac 360 atacagaact tctccacata ccacatttct tgcagctata aagtcccttg atggttggcc 420 gggtaccntt ttatccccta aaacctctgt tggacatcca aattatgnca gttggttata 480 tcc 483 <210> 75 <211> 1445 <212> DNA <213> Homo sapiens <400> 75 ggcacgaggc aagttcttaa catcaatgat catgctcctg agttctctca atactatgag 60 acttatgttt gtgaaaatgc aggctctggt caggtaattc agactatcag tgcagtggat 120 agagatgaat ccatagaaga gcaccatttt tactttaatc tatctgtaga agacactaac 180 aattcaagtt ttacaatcat agataatcaa gataacacag ctgtcatttt gactaataga 240 actggtttta accttcaaga agaacctgtc ttctacatct ccatcttaat tgccgacaat 300 ggaatcccgt cacttacaag tacaaacaca cttaccatcc atgtctgtga ctgtggtgac 360 agtgggagca cacagacctg ccagtaccag gagcttgtgc tttccatggg attcaagaca 420 gaagtcatca ttgctattct catttgcatt atgatcatat ttgggtttat ttttttgact 480 ttgggtttaa aacaacggag aaaacagatt ctatttcctg agaaaagtga agatttcaga 540 gagaatatat tccaatatga tgatgaaggg ggtggagaag aagatacaga ggcctttgat 600 atagcagagc tgaggagtag taccataatg cgggaacgca agactcggaa aaccacaagc 660 gctgagatca ggagcctata caggcagtct ttgcaagttg gccccgacag tgccatattc 720 aggaaattca ttctggaaaa gctcgaagaa gctaatactg atccgtgtgc ccctcctttt 780 gattccctcc agacctacgc ttttgaggga acagggtcat tagctggatc cctgagctcc 840 ttagaatcag cagtctctga tcaggatgaa agctatgatt accttaatga gttgggacct 900 cgctttaaaa gattagcatg catgtttggt tctgcagtgc agtcaaataa ttagggcttt 960 ttaccatcaa aatttttaaa agtgctaatg tgtattcgaa cccaatggta gtcttaaaga 1020 gttttgtgcc ctggctctat ggcggggaaa gccctagtct atggagtttt ctgatttccc 1080 ctggagtaaa tactccatgg ttattttaag ctacctacat gctgtcattg aacagagatg 1140 tggggagaaa tgtaaacaat cagctcacag gcatcaatac aaccagattt gaagtaaaat 1200 aatttaggaa gatattaaaa gtagatgaga ggacacaaga tgtagtcgat ccttatgcga 1260 ttatatcatt atttacttag gaaagagtaa aaataccaaa cgagaaaatt taaaggagca 1320 aaaatttgca agtcaaatag aaatgtacaa atcgagataa catttacatt tctatcatat 1380 tgacatgaaa attgaaaatg tatagtcaga gaaattttca tgaattattc catgaagtat 1440 tgttt 1445 <210> 76 <211> 3935 <212> DNA <213> Homo sapiens <400> 76 tccctcgctc accccatcct ctctcccgcc ccttcctgga ttccctcacc cgtctcgatc 60 ccctctccgc cctttcccag agacccagag cccctgaccc cccgcgccct ccccggagcc 120 ccccgcgcgt gccgcggcca tggcggccgt gcgcggggcg cccctgctca gctgcctcct 180 ggcgttgctg gccctgtgcc ctggagggcg cccgcagacg gtgctgaccg acgacgagat 240 cgaggagttc ctcgagggct tcctgtcaga gctagaacct gagccccggg aggacgacgt 300 ggaggccccg ccgcctcccg agcccacccc gcgggtccga aaagcccagg cggggggcaa 360 gccagggaag cggccaggga cggccgcaga agtgcctccg gaaaagacca aagacaaagg 420 gaagaaaggc aagaaagaca aaggccccaa ggtgcccaag gagtccttgg aggggtcccc 480 caggccgccc aagaagggga aggagaagcc acccaaggcc accaagaagc ccaaggagaa 540 gccacctaag gccaccaaga agcccaagga ggagccaccc aaggccacca agaagcccaa 600 agagaagcca cccaaggcca ccaagaagcc cccgtcaggg aagaggcccc ccattctggc 660 tccctcagaa accctggagt ggccactgcc cccacccccc agccctggcc ccgaggagct 720 accccaggag ggaggggcgc ccctctcaaa taactggcag aatccaggag aggagaccca 780 tgtggaggca caggagcacc agcctgagcc ggaggaggag accgagcaac ccacactgga 840 ctacaatgac cagatcgaga gggaggacta tgaggacttt gagtacattc ggcgccagaa 900 gcaacccagg ccacccccaa gcagaaggag gaggcccgag cgggtctggc cagagccccc 960 tgaggagaag gccccggccc cagccccgga ggagaggatt gagcctcctg tgaagcctct 1020 gctgcccccg ctgccccctg actatggtga tggttacgtg atccccaact acgatgacat 1080 ggactattac tttgggcctc ctccgcccca gaagcccgat gctgagcgcc agacggacga 1140 agagaaggag gagctgaaga aacccaaaaa ggaggacagc agccccaagg aggagaccga 1200 caagtgggca gtggagaagg gcaaggacca caaagagccc cgaaagggcg aggagttgga 1260 ggaggagtgg acgcctacgg agaaagtcaa gtgtcccccc attgggatgg agtcacaccg 1320 tattgaggac aaccagatcc gagcctcctc catgctgcgc cacggcctgg gggcacagcg 1380 cggccggctc aacatgcaga ccggtgccac tgaggacgac tactatgatg gtgcgtggtg 1440 tgccgaggac gatgccagga cccagtggat agaggtggac accaggagga ctacccggtt 1500 cacaggcgtc atcacccagg gcagagactc cagcatccat gacgattttg tgaccacctt 1560 cttcgtgggc ttcagcaatg acagccagac atgggtgatg tacaccaacg gctatgagga 1620 aatgaccttt catgggaacg tggacaagga cacacccgtg ctgagtgagc tcccagagcc 1680 ggtggtggct cgtttcatcc gcatctaccc actcacctgg aatggcagcc tgtgcatgcg 1740 cctggaggtg ctggggtgct ctgtggcccc tgtctacagc tactacgcac agaatgaggt 1800 ggtggccacc gatgacctgg atttccggca ccacagctac aaggacatgc gccagctcat 1860 gaaggtggtg aacgaggagt gccccaccat cacccgcact tacagcctgg gcaagagctc 1920 acgaggcctc aagatctatg ccatggagat ctcagacaac cctggggagc atgaactggg 1980 ggagcccgag ttccgctaca ctgctgggat ccatggcaac gaggtgctgg gccgagagct 2040 gttgctgctg ctcatgcagt acctgtgccg agagtaccgc gatgggaacc cacgtgtgcg 2100 cagcctggtg caggacacac gcatccacct ggtgccctca ctgaaccctg atggctacga 2160 ggtggcagcg cagatgggct cagagtttgg gaactgggcg ctgggactgt ggactgagga 2220 gggctttgac atctttgaag atttcccgga tctcaactct gtgctctggg gagctgagga 2280 gaggaaatgg gtcccctacc gggtccccaa caataacttg cccatccctg aacgctacct 2340 ttcgccagat gccacggtat ccacggaggt ccgggccatc attgcctgga tggagaagaa 2400 ccccttcgtg ctgggagcaa atctgaacgg cggcgagcgg ctagtatcct acccctacga 2460 tatggcccgc acgcctaccc aggagcagct gctggccgca gccatggcag cagcccgggg 2520 ggaggatgag gacgaggtct ccgaggccca ggagactcca gaccacgcca tcttccggtg 2580 gcttgccatc tccttcgcct ccgcacacct caccttgacc gagccctacc gcggaggctg 2640 ccaagcccag gactacaccg gcggcatggg catcgtcaac ggggccaagt ggaacccccg 2700 gaccgggact atcaatgact tcagttacct gcataccaac tgcctggagc tctccttcta 2760 cctgggctgt gacaagttcc ctcatgagag tgagctgccc cgcgagtggg agaacaacaa 2820 ggaggcgctg ctcaccttca tggagcaggt gcaccgcggc attaaggggg tggtgacgga 2880 cgagcaaggc atccccattg ccaacgccac catctctgtg agtggcatta atcacggcgt 2940 gaagacagcc agtggtggtg attactggcg aatcttgaac ccgggtgagt accgcgtgac 3000 agcccacgcg gagggctaca ccccgagcgc caagacctgc aatgttgact atgacatcgg 3060 ggccactcag tgcaacttca tcctggctcg ctccaactgg aagcgcatcc gggagatcat 3120 ggccatgaac gggaaccggc ctatcccaca catagaccca tcgcgcccta tgacccccca 3180 acagcgacgc ctgcagcagc gacgcctaca acaccgcctg cggcttcggg cacagatgcg 3240 gctgcggcgc ctcaacgcca ccaccaccct aggcccccac actgtgcctc ccacgctgcc 3300 ccctgcccct gccaccaccc tgagcactac catagagccc tggggcctca taccgccaac 3360 caccgctggc tgggaggagt cggagactga gacctacaca gaggtggtga cagagtttgg 3420 gaccgaggtg gagcccgagt ttgggaccaa ggtggagccc gagtttgaga cccagttgga 3480 gcctgagttc gagacccagc tggaacccga gtttgaggaa gaggaggagg aggagaaaga 3540 ggaggagata gccactggcc aggcattccc cttcacaaca gtagagacct acacagtgaa 3600 ctttggggac ttctgagatc agcgtcctac caagacccca gcccaactca agctacagca 3660 gcagcacttc ccaagcctgc tgaccacagt cacatcaccc atcagcacat ggaaggcccc 3720 tggtatggac actgaaagga agggctggtc ctgccccttt gagggggtgc aaacatgact 3780 gggacctaag agccagaggc tgtgtagagg ctcctgctcc acctgccagt ctcgtaagag 3840 atggggttgc tgcagtgttg gagtaggggc agagggaggg agccaaggtc actccaataa 3900 aacaagctca tggcaaaaaa aaaaaaaaaa aaaaa 3935 <210> 77 <211> 3672 <212> DNA <213> Homo sapiens <400> 77 acatgtgcat atttcattcc ccaggcagac attttttaga aatcaataca tgccccaata 60 ttggaaagac ttgttcttcc acggtgacta cagtacatgc tgaagcgtgc cgtttcagcc 120 ctcatttaat tcaatttgta agtagcgcac gagcctctgt gggggaggat aggctgaaaa 180 aaaaaagtgg gctcgtattt atctacagga ctccatatag tcatatatag gcatataaat 240 ctatgctttt tctttgtttt tttctttctt cctttctttc aaaggtttgc attaactttt 300 caaagtagtt cctatagggg cattgaggag cttcctcatt ctgggaaaac tgagaaaacc 360 catattctcc taatacaacc cgtaatagca tttttgcctg cctcgaggca gagtttcccg 420 tgagcaataa actcagcttt tttgtggggc acagtactgg atttgacagt gattccccac 480 gtgtgttcat ctgcacccac cgagccaggc agaggccagc cctccgtggt gcacacagca 540 cgcgcctcag tccatcccat tttagtcttt aaaccctcag gaagtcacag tctccggaca 600 ccacaccaca ttgagcccaa caggtccacg atggatccac ctagtcccac cccagccttt 660 ttctttcatc tgaacagaat gtgcattttt ggaagcctcc ctcactctcc atgctggcag 720 agcaggaggg agactgaagt aagagatggc agagggagat ggtggcaaaa aggtttagat 780 gcaggagaac agtaagatgg atggttccgg ccagagtcga tgtggggagg aacagagggc 840 tgaagggaga gggggctgac tgttccattc tagctttggc acaaagcagc agaaaggggg 900 aaaagccaat agaaatttcc ttagcttccc caccatatgt attttcatgg atttgagagg 960 aaagagagga aaatggggga atgggttgca aaatagaaat gagcttaatc caggccgcag 1020 agccagggaa ggtgagtaac cttaggaggg tgctagactt tagaagccag ataggaagaa 1080 tcagtctaaa ctggccatgc tttggaaggg acaagactat gtgctccgct gcccaccttc 1140 agcctgcaat gagggactga ggcccacgag tctttccagc tcttcctcca ttctggccag 1200 tccctgcatc ctccctgggg tggaggatgg aaggaaagct gggacaagca gggaacgcat 1260 gattcaggga tgctgtcact cggcagccag attccgaaac tcccattctc caatgacttc 1320 ctcaaccaat gggtggcctt gtgactgttc tttaaggctg aagatatcca ggaaaggggg 1380 cttggacact ggccaaggag accccttcgt gctgtggaca cagctctctt cactctttgc 1440 tcatggcatg acacagcgga gaccgcctcc aacaacgaat ttggggctac gaagaggaat 1500 agcgaaaaag caaatctgtt tcaactgatg ggaaccctat agctatagaa cttgggggct 1560 atctcctatg cccctggaca ggacagttgg ctggggacag gagaagtgct caatcttcat 1620 gagacaaagg ggcccgatca aggcagccac aaggccttga cctgccgagt cagcatgccc 1680 catctctctc gacagctgtc ccctaaaccc aactcacgtt tctgtatgtc ttaggccagt 1740 atcccaaacc tcttccacgt cactgttctt tccacccatt ctccctttgc atcttgagca 1800 gttatccaac taggatctgc caagtggata ctggggtgcc actcccctga gaaaagactg 1860 agccaggaac tacaagctcc ccccacattc ctcccagcct ggacctaatt cttgagaggg 1920 gctctctctt cacggactgt gtctggactt tgagcaggct tctgcccctt gcgttggctc 1980 tttgctgcca gccatcaggt gggggattag agcctggtgt aagtgcgcca gactcttccg 2040 gtttccaaag ttcgtgcctg cgaacccaaa cctgtgagtc tcttctgcat gcaggagttt 2100 ctcctgggca gctggtcact ccccagagaa gctgggcctt catggacaca tggaactaag 2160 cctcccaaat gggagttctg gctgagccca gggtggggag atcctgggaa gggaggcact 2220 ggaggaagac ggcacctctt cccccatggc agggtgtgag ggaggcaggt ttggaatggt 2280 gcgagtatgg caatctaagc aggggtctgg tctctttgac tccaggctcg ctttggccga 2340 ctgtctgctc acccagagac cttggactcc ggactatcca tggctccgaa tctaagtgct 2400 gcccactccc atgctcacac ccacagaagg tcttcccatc ccctttagat tcgtgcctca 2460 ctccaccagt gaggaagatg cctctgtctt tcccacgact gccaggagat agggaagccc 2520 agccaggact gaccctcctt cctccagcct gccctgaccc acctggcaaa gcagggcaca 2580 tggggaggaa gagactggaa cctttctttg acagccaggc ctagacagac aggcctgggg 2640 acactggccc atgaggggag gaaggcaggc gcacgaggtc cagggaggcc cttttctgat 2700 catgcccctt ctctcccacc ccatctcccc accaccacct ctgtggcctc catggtaccc 2760 ccacagggct ggcctcccct agagggtggg cctcaaccac ctcgtcccgc cacgcaccgg 2820 ttagtgagac agggctgcca cgcaaccgcc aagcccccct caaggtggga cagtaccccg 2880 gacccatcca ctcactcctg agaggctccg gcccagaatg ggaacctcag agaagagctc 2940 taaggagaag aaaccccata gcgtcagaga ggatatgtct ggcttccaag agaaaggagg 3000 ctccgttttg caaagtggag gagggacgag ggacaggggt ttcaccagcc agcaacctgg 3060 gccttgtact gtctgtgttt ttaaaaccac taaagtgcaa gaattacatt gcactgtttc 3120 tccacttttt attttctctt aggcttttgt ttctatttca aacatacttt cttggttttc 3180 taatggagta tatagtttag tcatttcaca gactctggcc tcctctcctg aaatcctttt 3240 ggatggggaa agggaaggtg gggagggtcc gaggggaagg ggaccccagc ttccctgtgc 3300 ccgctcaccc cactccacca gtccccggtc gccagccgga gtctcctctc taccgccact 3360 gtcacaccgt agcccacatg gatagcacag ttgtcagaca agattccttc agattccgag 3420 ttgctaccgg ttgttttcgt tgttgttgtt gttgtttttc tttttctttt tttttttgaa 3480 gacagcaata accacagtac atattactgt agttctctat agttttacat acattcatac 3540 cataactctg ttctctcctc ttttttgttt tcaactttaa aaacaaaaat aaacgatgat 3600 aatctttact ggtgaaaagg atggaaaaat aaatcaacaa atgcaaccag tttgtgagaa 3660 aaaaaaaaaa aa 3672 <210> 78 <211> 478 <212> DNA <213> Homo sapiens <400> 78 ttttcaattt ttaatttttt tatttagaaa taataaaata agacataata tataaaaata 60 tgtacaatcc atggtttgtg cagtacaata ggaagacttt agatacaaaa agacagcaaa 120 tgggaaaata ataactatca cgattgtcaa tggctaggat tgttcaactt gccagagccc 180 agagcggaaa cccaaaatta ccagaaaaga gattctactt tgctgagggt tggggatggg 240 caggtagcta tgccacactt ttttttttcc caccttaaca ttattagaca cagagtgaaa 300 aagaactcac tctacttctc aggacaagct tttgctttta ctgagtggtt tattataaaa 360 tatgaagtga catttattaa ttgtaaggga aatatgattt acgggacaga actcatcaaa 420 taaacagagt tgagatagga gtgtactggt aagaaaggaa gtaaagagaa gaaagatg 478 <210> 79 <211> 2156 <212> DNA <213> Homo sapiens <400> 79 agcgcagcac tccccgctcg ttggcccggg tatcccagcg cggacccacg cgatacgctg 60 acgccccgac gccgatccgg ccgagccaag taagggggac ggcccgagac ggagaaggga 120 gagagtggga gtttcccagc ccgcagaact ttcgaagttg agaagagaac ccctggaacg 180 tgcgctcagc actgggattt tctggactca acgatgactc tgaataatgt caccatgcgc 240 cagggcactg tgggcatgca gccacagcag cagcgctgga gcatcccagc tgatggcagg 300 catctgatgg tccagaaaga gccccaccag tacagccacc gcaaccgcca ttctgctacc 360 cctgaggacc actgccgccg aagctggtcc tctgactcca cagactcagt catctcctct 420 gagtcaggga acacctacta ccgagtggtg ctcatagggg agcagggggt gggcaagtcc 480 actctggcca acatctttgc aggtgtgcat gacagcatgg acagcgactg cgaggtgctg 540 ggagaagata catatgaacg aaccctgatg gttgatgggg aaagtgcaac gattatactc 600 ctggatatgt gggaaaataa gggggaaaat gaatggctcc atgaccactg catgcaggtc 660 ggggacgcat acctgattgt ctactcaatc acagaccgag cgagcttcga gaaggcatct 720 gagctgcgaa tccagctccg cagggcccgg cagacagagg acattcccat aattttggtt 780 ggcaacaaaa gtgacttagt gcggtgccga gaagtgtctg tatcagaagg gagagcctgt 840 gcagtggtgt ttgactgcaa gttcatcgag acctctgcag ctgtccagca caacgtgaag 900 gagctgtttg agggcattgt gcgacaggtg cgccttcggc gggacagcaa ggagaagaat 960 gaacggcggc tggcctacca gaaaaggaag gagagcatgc ccaggaaagc caggcgcttc 1020 tggggcaaga tcgtggccaa aaacaacaag aatatggcct tcaagctcaa gtccaaatcc 1080 tgccatgacc tctctgtact ctaggaaccc agggtcaccc agatgtccct ttgatggccc 1140 ttgttgaagg ccattgggac caataatcta tattagattg aatacttaag ttagatgtgg 1200 tttcccccat tgtagcaggg agctagcgta ttagccttgt gggcaacatg atgcatggga 1260 aatgaaagat ttttgtaaaa agtcagtatt tatttccagg aaaagcctga ccttgctatt 1320 tgaacaccca agactcttta gaggatgtgt ttggtgttca catgtgtttc ttctattttg 1380 gatagtaggg aagtaaagct tacaaagaat gcctagaaca agaacttttc atcattaaaa 1440 atttttccca gtgttctgat atgtgacttt gaggccaatg agtcataaac aaatataaga 1500 aagctgtcaa tgagtttctt caaaggaggg aaaactttct acgaatctaa gatccatgga 1560 gctagaattg tagaactagg ctcatcagaa tcgtgactat tattgctcca tcaaactgtg 1620 aaaagaaatg atgtggacct tgctggaaac aaaggcttag caaacaattt ttgttcaatg 1680 cccaccgaga catatagaat tgggaactga tacatgtgtc ccttataggc tcaaaaatta 1740 tatcttacaa tttcttattt agggggaaat tatttgaatc agattctatt tagtcaaacc 1800 accttttatg ttttattatt tttgaattca tggagccatc ataaaaatat ttttaaaatc 1860 agaattattg ataccctgta gtgcaaaatg tcaattttta atgtataatc agaagtctga 1920 attttcataa aacatatagc ataaaaacct ccagtacttt ggttgaccct tgtatgtcac 1980 agctctgctc tatttattat tattttgcaa aataaccatt ttaacatttg ataaagcata 2040 tttatgaaca tatttcttaa taagaaaaat atccatttta ttaccatttt ctatcttttt 2100 caaaatatgc aagtttttac ctatatgtct tataataaaa gaaataaaat atttga 2156 <210> 80 <211> 536 <212> DNA <213> Homo sapiens <400> 80 ctgttttaca agaatttaat aacaaagatt aaacaatcaa aatgaaccat gggactcaaa 60 aacatcctaa gttgcaaaat caatacataa tggaaaatct gacgacattt aaaactgtaa 120 gattaattct tttcattgag ttcttctact tgcatttgca aacagagaga atgacgcgcc 180 tgtttcaggg attctttagc cttagcaagg tcttctttta acttgttgta ttgctgcaca 240 tcaaagtgct gttgctttga tttcttgtgg aagaactgaa gaaattgcct actcttaaca 300 gctgagtaag tataatcctg ccgagtgact ataaaagtat gcaaaaaaga ccatagaatn 360 gcaaatgtga ttaaggtatg taactggctc catgatatcc aaggagtaca ccacaccacg 420 tgagccaggg ccagtgcccc accctgatgg accancagtg ccaatccagc caaaggagtc 480 acattggttt tggcttccga atgagcctct aattccactt tcaacctgtt taaggg 536 <210> 81 <211> 551 <212> DNA <213> Homo sapiens <400> 81 ctgctaatat ccaaagttta tcatagctat gacaatatca gtcccaacca ggttacaagt 60 ttgttacaaa ttacaaacta cttaaaaaca gttttgaaaa aaaatatatc ccaaatatta 120 acactaaaca ctaccctgga gttagaaaaa ctgtaaatgg gatgaggaaa ctgaggtacc 180 agtggtgaca taaggccttt ttgtctgaca gactgttttc tgaagtcagt gtaggatgta 240 gtctaacaga cctccagaag aataattctt ccaactacca aatcagcaca ctgagacatt 300 aaaatactca aatcagaata aggaccgacc ctaagtttaa atgtgtattt ggattaacat 360 ttttcagcag gagtgtatga agaggggaga ggatacaagt caaagactgg gtagtcaggc 420 cccctgtccc ttgcagaatc ccttacactc accaaacaga atattaaagc aagagctacc 480 caataagaag agactaaaga ccccaactca ctccttttgt gttgggcaga agaacctgng 540 ctgtgagtca a 551 <210> 82 <211> 556 <212> DNA <213> Homo sapiens <400> 82 tttttttttc agaaattcat accacaccag acagatgtgt tttattaaaa aagaaagaaa 60 accctttaat cagaaagtct gattaaattc aatagtaact caaactctta aaaaatttct 120 ggaaaagtca acaggataca tacatcacag aaaagcaggc agctgctgac agttctttgg 180 tggaaaagta agttgcgtac ttacccaagc tgcccaaatg attatcaagc caagtttggt 240 ttttcaaaaa taggttttaa gatacaccaa agaaactata caatacaaaa atttaacaat 300 gaagttaaag tatatagcaa aagccaaata tgacaacaca catgtataat gtagaaaaga 360 atcctttcag tcctagaaaa ctaaaatggg gagaacttac tgaagggtaa catacataaa 420 atgagtacta atagcaagga ataatcctaa acattttccc aataaactga ctaagcctca 480 aaaggacagc ttaggaaaat gattaacatg cagtttttct ttnttcctag ccaattcagt 540 tctacttaga taaatc 556 <210> 83 <211> 618 <212> DNA <213> Homo sapiens <400> 83 catcataaat ctcctaaata ttttacagtt gactctcatg agctgattgg agtcagctgg 60 aacataccac tgcctctaga ctaaggccag cagatttagc aaatacagac tgccccagtt 120 cattgaattt tagataaatg aaataaatct ataaggttaa gtatgtcccc agaactgcat 180 ggaacatnnt taatctaaac aatgatttgt tgttcacctg aaattcaaat ttagctgggt 240 gtcctgtatt tcatctggca accctacttc agacccaggt gtaaggtaca tggatgtgct 300 ttggtcaagg aataggccaa ggcagagatc catgcctgca tgactcagtg ggtttggtgc 360 acaggcacac cacctccact tgttatataa cctgtttgtg taagttcata cttgggtctg 420 agccactgtt ggtctgtaaa aggtaattgg tcccgctaat gctggtacaa ggggctcctg 480 ggggttccgg ctcagctcca acatggcttg acatgggtgg gcacacctgg gcgccccggt 540 aagagagaga gagagcccaa gctgtccggt ttgcagatgg acangaagga gccngacaca 600 gctcagcttg ttcacgcc 618 <210> 84 <211> 627 <212> DNA <213> Homo sapiens <400> 84 tttttttttt tttttttttt tttttttttt tttttttttt ttccccccgg ggcattttta 60 tttttttaca tgggatggga acaacgtgaa catgggtcaa aaaagtcagt tgcccaaaaa 120 cccttcaccc atttttaacc caaagggagc ataaacatgg aggggctggg ggttaggctg 180 ggggaaacca cccttccctg ttaagggctc gtggtccaag cccacaacca aagggtgctt 240 tgggtggtgt ccaaaaacat ccantgccgt ttccggggag gagggacaaa aaaagaaagg 300 ggagtcacaa aggaggctgc aaatgaccac aagtttattg gactttggcc tccccctgct 360 gtttgatgaa gttgatgacc ccattggtaa aagcgtnggg agaggtcact tgagcactgc 420 catcaagctc aggctctatt ttnttagcca gttgttttcc cagctccact ccccactggt 480 caaggctggt gatgtcccaa atgatgcttg aacgaagatc ttgtgctcat acatggcgac 540 caggcttcaa gcatgaatgg gtgagcttgg tgacaacaaa aagtgggttg gcgattcctt 600 taaaaaactt atggggagca gccttca 627 <210> 85 <211> 474 <212> DNA <213> Homo sapiens <400> 85 ccgtctggtc tcataaccac tattgatatt ttccatggat tcagaactac gttttagaac 60 agggcactct gggttttctt tgaggcatgc acagtccacc ttgtacttac aatttccata 120 gtcaaaatca aaggcaatag taatttcagt tccctttgga atactgtgta tagaataaat 180 ataaagatgt atggttccat cttgaatttc atgcctcacc tctgcattgg gtgtacaaga 240 ccgcctgatg aatcgagcct cattcccaaa agtccttgca tcaacacaca tttctagccc 300 atgaaattta gagtagaata acacaaaagg gtatggtctt ttaaagaaat acccatttgc 360 ttcaaactgt tctctcagca taaacttccc tctgtattca atgataagtg catcaggagg 420 caaatctttt gcagatttaa gaattttctt attcttttgt atatggctct ctac 474 <210> 86 <211> 549 <212> DNA <213> Homo sapiens <400> 86 gatcaanatt cattcttcat ttgccctcgt aacgaaaata gatttttaaa tgncctcaaa 60 tatacaaaca tcattgatgc acacacattc cagaaatgca gaggtatgct gctgcacggg 120 gtaggggtgc gggaggcggc ctggctcatg ncnangaccg tgcccagccc gggcctggca 180 ggtagctggc cactgataaa tgccactggg atcctaggag aagctgggga ccatgcgtga 240 ggtactgaag gggaccatgg tggatggcat cctggggcac tttgtagctt gtctgaggga 300 aaggcctctg ctgccataga aaagctggac acatgtcacc ctggggccct gacatcctaa 360 aatgccccac ttgactacca gtcactagga gaaaggtctc cggctatgcc ttcccagtga 420 tgctttcccc agagtgactt ggtacaggtn gggggacagg ttttcttcag aaaccgtagg 480 cctttcttgt cttggccccc taaagaggnc ccaagatcan ggaaacttcc cagttttaaa 540 aaatatctg 549 <210> 87 <211> 556 <212> DNA <213> Homo sapiens <400> 87 tttttttttt tttttttttt tttttttttt tttttttttt tttttttggc tgcttggggg 60 aacatggagt ttattcaggg ggggggacag gcgggcggct caaaaacagg ggccccccac 120 ctccgccatg acaacaaaca cattgacatg ggggggttta ccccccaagc ggtcaatggt 180 cttttgtgta aaggccaacg gaagggcctc ggggcccacc atgcaggaaa aggggtcccc 240 ctttttccaa tcctcggttg ccacccccaa tatgctggtc acaacaaagg ggggggtgcc 300 ctggctgggc tcctgccggg atgcccaaat aaggtacttt tcggggggca attcctgtga 360 cccctgcaac cagcaaacca acacgtcctt ggggctgaaa ccgggtgcca ggcacgtaag 420 ngtaaccaac ttgttaaagg ccagctcctc cgacgggggg gggagcaggt ggacctcggg 480 cccgaatgtg ttccggattt tgagaggggg gcgggtaacg gggtctttga ctcgggtagg 540 caccaaagca aggaag 556 <210> 88 <211> 579 <212> DNA <213> Homo sapiens <400> 88 aaaatgactg gctgagaatg aaccagaaat gccatttgcc aaacagttgt aactagaaat 60 ttgattctca cagtccattc ttttctttgt ccttaagatg acattgttag tgttcacgtc 120 ccatgttcag tgtccaaacc ggcaatgtaa aaagtatcct gtgtggctta acaggaaatc 180 tgtttatgtc tctttatttg aaaccagttt tactctcagt ggttctttaa gttcaatgaa 240 gtctgccagg aacattggtt ggtagtatta ttccgacacc tttaatttcc aaaatctgaa 300 gttcctgcta cgtttaccac cttcatgatc ttcttgaact ggtaactgat taggttgaac 360 ttatggaaga tttgtggact taactcaaaa gtaacctctc agtgttctat agaacatgta 420 tttggtggta actgaaccta ccaggagaaa tggtttggaa ttcnatatgg tgcaattttt 480 tcaacaaatg gcaaaaaaaa tacagcacat gtattgacaa gcttctgtca agagcttgag 540 ttgaaatttg atttaaggaa attaatccat gattggtcc 579 <210> 89 <211> 1717 <212> DNA <213> Homo sapiens <400> 89 gtggattctt gtccatagtg catctgcttt aagaattaac gaaagcagtg tcaagacagt 60 aaggattcaa accatttgcc aaaaatgagt ctaagtgcat ttactctctt cctggcattg 120 attggtggta ccagtggcca gtactatgat tatgattttc ccctatcaat ttatgggcaa 180 tcatcaccaa actgtgcacc agaatgtaac tgccctgaaa gctacccaag tgccatgtac 240 tgtgatgagc tgaaattgaa aagtgtacca atggtgcctc ctggaatcaa gtatctttac 300 cttaggaata accagattga ccatattgat gaaaaggcct ttgagaatgt aactgatctg 360 cagtggctca ttctagatca caaccttcta gaaaactcca agataaaagg gagagttttc 420 tctaaattga aacaactgaa gaagctgcat ataaaccaca acaacctgac agagtctgtg 480 ggcccacttc ccaaatctct ggaggatctg cagcttactc ataacaagat cacaaagctg 540 ggctcttttg aaggattggt aaacctgacc ttcatccatc tccagcacaa tcggctgaaa 600 gaggatgctg tttcagctgc ttttaaaggt cttaaatcac tcgaatacct tgacttgagc 660 ttcaatcaga tagccagact gccttctggt ctccctgtct ctcttctaac tctctactta 720 gacaacaata agatcagcaa catccctgat gagtatttca agcgttttaa tgcattgcag 780 tatctgcgtt tatctcacaa cgaactggct gatagtggaa tacctggaaa ttctttcaat 840 gtgtcatccc tggttgagct ggatctgtcc tataacaagc ttaaaaacat accaactgtc 900 aatgaaaacc ttgaaaacta ttacctggag gtcaatcaac ttgagaagtt tgacataaag 960 agcttctgca agatcctggg gccattatcc tactccaaga tcaagcattt gcgtttggat 1020 ggcaatcgca tctcagaaac cagtcttcca ccggatatgt atgaatgtct acgtgttgct 1080 aacgaagtca ctcttaatta atatctgtat cctggaacaa tattttatgg ttatgttttt 1140 ctgtgtgtca gttttcatag tatccatatt ttattactgt ttattacttc catgaatttt 1200 aaaatctgag ggaaatgttt tgtaaacatt tatttttttt aaagaaaaga tgaaaggcag 1260 gcctatttca tcacaagaac acacacatat acacgaatag acatcaaact caatgcttta 1320 tttgtaaatt tagtgttttt ttatttctac tgtcaaatga tgtgcaaaac cttttactgg 1380 ttgcatggaa atcagccaag ttttataatc cttaaatctt aatgttcctc aaagcttgga 1440 ttaaatacat atggatgtta ctctcttgca ccaaattatc ttgatacatt caaatttgtc 1500 tggtaaaaaa ataggtggta gatattgagg ccaagaatat tgcaaaatac atgaagcttc 1560 atgcacttaa agaagtattt ttagaataag aatttgcata cttacctagt gaaacttttc 1620 tagaattatt tttcactcta agtcatgtat gtttctcttt gattatttgc atgttatgtt 1680 taataagcta ctagcaaaat aaaacatagc aaatggc 1717 <210> 90 <211> 479 <212> DNA <213> Homo sapiens <400> 90 tgatgaatta agtcacacat aaatttctat tatagcttct ggtaactccn ttcctaaaag 60 tcttctcagc taatgtggaa aattctagct tctcttttca ttttttgaga cagggactgg 120 ctcagtcacc cagactggag tgctgcggcn gttcatggct cactgcaggc ttgacctccc 180 aggctccagc aatcctctca tgtcagcctc ccaggtagct gggaccaaca ggctcgcaat 240 accgcatgtg actaattttt gtattttttg tagagacggg gcttcaccat gcagcacagg 300 ctgggtcttg aactcctggg gctccagcaa tcctcccacc tcggtctccc aaagtgctgg 360 gagccactgc ccccagcctg atttctcttt tctatcttta ctccatttat ccacttacat 420 acctttacct ttcaccaata aaatgtacta atctttgaat gggntatgtt acataaaag 479 <210> 91 <211> 545 <212> DNA <213> Homo sapiens <400> 91 tttttttgca acaacacctt ggacctctgt gtgggggttt gactgacctc aagctgatat 60 tattggacct tgtgcagctt tgataaccca tgtgagagtc taggcaggac cagtggggcc 120 caaatcttgc tgctcttgta cttttaggca ctgcccttgc agactcacct ttctccacct 180 gccctggaga aaggtagggt gtgctgggcc tgccccttgc aaatgggatt caccagtttc 240 atttatttga ctctactgcc acagtgaaaa gagcaaacag ctattgggtt gcaaacctcc 300 tttgacatta ggaaatgttg actttgtaac aataaaactt tggtcctaga aagacacggt 360 tgtcctggga gtttgtagtg ttaagttgca acaacaacaa caaaaagcaa caaaaccagc 420 ttaggataac actttttgtt gcttgttctt aaagatgtct cactatgatt aaaacccttt 480 tcattaatgt agtgaaagcc acacaggagt tccttcttcc aggaggagaa taccaagcac 540 atcac 545 <210> 92 <211> 460 <212> DNA <213> Homo sapiens <400> 92 tttttttttt tatttttatt ttttgaagga ggattattta ctggtggtct aaaagaagta 60 ccttcaactt cttcataatt gtagccaaag cggaaatgga atatttaata attcttacat 120 ctcactaatg tagtcttctg agataacaat taagcagaga gattattttc tatgttcaaa 180 ctttaaacac tttgtaaaga taattgggat ttcataacaa atgataataa gtggttttgt 240 gcattaattt tcttgatacc caataacatg ccaattaaaa tccagacttc acattggcac 300 ctaatgaaca cagcagaatg accaaagttg agtgctagtc attgtcatag atgcagccat 360 cagcaatatc atcatagatc tctccatcat tgtccgctag gtaactccga aggacataac 420 catatttccc ttcttcattt ctgcagagaa cttttgtgtc 460 <210> 93 <211> 1260 <212> DNA <213> Homo sapiens <400> 93 atgaagtttc cagggccttt ggaaaaccag agattgtctt tcctgttgga aaaggcaatc 60 actagggaag cacagatgtg gaaagtgaat gtgcggaaaa tgccttcaaa tcagaatgtt 120 tctccatccc agagagatga agtaattcaa tggctggcca aactcaagta ccaattcaac 180 ctttacccag aaacatttgc tctggctagc agtcttttgg ataggttttt agctaccgta 240 aaggctcatc caaaatactt gagttgtatt gcaatcagct gttttttcct agctgccaag 300 actgttgagg aagatgagag aattccagta ctaaaggtat tggcaagaga cagtttctgt 360 ggatgttcct catctgaaat tttgagaatg gagagaatta ttctggataa gttgaattgg 420 gatcttcaca cagccacacc attggatttt cttcatattt tccatgccat tgcagtgtca 480 actaggcctc agttactttt cagtttgccc aaattgagcc catctcaaca tttggcagtc 540 cttaccaagc aactacttca ctgtatggcc tgcaaccaac ttctgcaatt cagaggatcc 600 atgcttgctc tggccatggt tagtctggaa atggagaaac tcattcctga ttggctttct 660 cttacaattg aactgcttca gaaagcacag atggatagct cccagttgat ccattgtcgg 720 gagcttgtgg cacatcacct ttctactctg cagtcttccc tgcctctgaa ttccgtttat 780 gtctaccgtc ccctcaagca caccctggtg acctgtgaca aaggagtgtt cagattacat 840 ccctcctctg tcccaggccc agacttctcc aaggacaaca gcaagccaga agtgccagtc 900 agaggtacag cagcctttta ccatcatctc ccagctgcca gtgggtgcaa gcagacctct 960 actaaacgca aagtagagga aatggaagtg gatgacttct atgatggaat caaacggctc 1020 tataatgaag ataatgtctc agaaaatgtg ggttctgtgt gtggcactga tttatcaaga 1080 caagagggac atgcttcccc ttgtccacct ttgcagcctg tttctgtcat gtagtttcaa 1140 caagtgctac ctttgagtgt aaactaaggt agactacttt gggaatgaga acatccaaaa 1200 tcaggaaagg ctgtagaagg aaatatacct taacaggctg atttggagtg acccagaaaa 1260 <210> 94 <211> 5421 <212> DNA <213> Homo sapiens <400> 94 ccgggatccg gttttttttg tttttaaaag tgtaatttcc tttttatttg catctgttta 60 tgactgaaaa aaatgactag ttattatgaa gacactactg ttgaagatgg atattttaac 120 atggagtttc aacaaaatta cttcttgaga cagagctgat gtgtttttta aataacgtga 180 ttttaagcat atatttgaac aaaactaaaa catttagtat tatgaatatg aaaaaagatc 240 agtaaatcaa tgtactcttc taggctgaat taaggtagac tatttaaggt ttcaaaaaag 300 tttggctggg gcagaataag ttttacaaaa cccatgccat ccaaaattaa gatgacatgt 360 agcagcaaga agtattccaa tgtctcataa ccagttctcg caagcaatgt gtattcctta 420 ctttaaggaa gtgtcaaaca aatagaaaaa tctggaagaa tttactaagt gtaataaatt 480 agaggtaaat cgtaataaaa gaatttatgt ctcacaaaaa tattcacaag tgggagtttt 540 cttttaccaa cttctcagag tccttctagc cccctcttca cttctgaaag atgggattta 600 ccaaaatctg gtttacattt aacttttcag ggacacatga cctgaaaaga aagatgtcag 660 ataatactga cattgcctca tgcactttct ttgtatcagt ccttcttctg taagtaatca 720 gaattgggtc caaatggcat agaatcaaac attatgtatc atgccaaata ccacttcctg 780 cccaacaaaa tttcatcttt ctccagtaat gaagaggtgg acattcttgt tggactgtag 840 catctgtgcc gcccgctcca caccaaccac ggcagctaac ctctgggcat catatttgga 900 gtagagaaca gtgcaggtcc acgtggcctc ttctcctctg ttggtggctc tcagcatatt 960 acagatttca ctgtaaaagt gtggatatgt cggcagttca tagaaaatca ggttcctgat 1020 gccttttatt gctgtagttt atttccaccc ccttccctcc tgttttctct ctctccttct 1080 ctctctctct ctctctctct tttttttccg ccctagctgg ggctgtgttg gaggagagga 1140 agaaagagag acagaggatt gcattcatcc gttacgttct tgaaatttcc taatagcaag 1200 accagcgaag cggttgcacc cttttcaatc ttgcaaagga aaaaaacaaa acaaaacaaa 1260 aaaaacccaa gtccccttcc cggcagtttt tgccttaaag ctgccctctt gaaattaatt 1320 ttttcccagg agagagatgt cttatcaggg gaagaaaaat attccacgca tcacgagcga 1380 tcgtcttctg atcaaaggag gtaaaattgt taatgatgac cagtcgttct atgcagacat 1440 atacatggaa gatgggttga tcaagcaaat aggagaaaat ctgattgtgc caggaggagt 1500 gaagaccatc gaggcccact cccggatggt gatccccgga ggaattgacg tccacactcg 1560 tttccagatg cctgatcagg gaatgacgtc tgctgatgat ttcttccaag gaaccaaggc 1620 ggccctggct gggggaacca ctatgatcat tgaccacgtt gttcctgagc ctgggacaag 1680 cctgctcgct gcctttgacc agtggaggga atgggccgac agcaagtcct gctgtgacta 1740 ctctctgcat gtggacatca gcgagtggca taagggcatc caggaggaga tggaagcgct 1800 tgtgaaggat cacggggtaa attccttcct cgtgtacatg gctttcaaag atcgcttcca 1860 gctaacggat tgccagattt atgaagtact gagtgtgatc cgggatattg gcgccatagc 1920 ccaagtccac gcagaaaatg gcgacatcat tgcagaggag cagcagagga tcctggatct 1980 gggcatcacg ggccccgagg gacatgtgct gagccgacct gaggaggtcg aggccgaagc 2040 cgtgaatcgt gccatcacca tcgccaacca gaccaactgc ccgctgtata tcaccaaggt 2100 gatgagcaaa agctctgctg aggtcatcgc ccaggcacgg aagaagggaa ctgtggtgta 2160 tggcgagccc atcactgcca gcttgggaac ggacggctcc cattactgga gcaagaactg 2220 ggccaaggct gctgcctttg tcacctcccc acccttgagc cctgatccaa ccactccaga 2280 ctttctcaac tccttgctgt cctgtggaga cctccaggtc acgggcagtg cccattgcac 2340 gtttaacact gcccagaagg ctgtaggaaa ggacaacttc accctgattc cggagggcac 2400 caatggcact gaggagcgga tgtccgtcat ctgggacaag gctgtggtca ctgggaagat 2460 ggatgagaac cagtttgtgg ctgtgaccag caccaatgca gccaaagtct tcaaccttta 2520 cccccggaaa ggccgcattg ctgtgggatc cgatgccgac ctggtcatct gggaccccga 2580 cagcgttaaa accatctctg ccaagacaca caacagctct ctcgagtaca acatctttga 2640 aggcatggag tgccgcggct ccccactggt ggtcatcagc caggggaaga ttgtcctgga 2700 ggacggcacc ctgcatgtca ccgaaggctc tggacgctac attccccgga agcccttccc 2760 tgattttgtt tacaagcgta tcaaggcaag gagcaggctg gctgagctga gaggggttcc 2820 tcgtggcctg tatgacggac ctgtgtgtga agtgtctgtg acgcccaaga cagtcactcc 2880 agcctcctcg gccaagacgt ctcctgccaa gcagcaggcc ccacctgtcc ggaacctgca 2940 ccagtctgga ttcagtttgt ctggtgctca gattgatgac aacattcccc gccgcaccac 3000 ccagcgtatc gtggcgcccc ccggtggccg tgccaacatc accagcctgg gctagagctc 3060 ctgggctgtg cgtccactgg ggactgggga tgggacacct gaggacattc tgagacttct 3120 ttcttccttc cttttttttt tttgtttttt tttttaagag cctgtgatag ttactgtgga 3180 gcagccagtt catggggtcc cccttgggcc cacaccccgt ctctcaccaa gagttactga 3240 ttttgctcat ccacttccct acacatctat gggtatcaca cccaagacta cccaccaagc 3300 tcatacaggg aaccacaccc aacacttaga catgcgaaca agcagccccc agcgagggtc 3360 tccttcgcct tcaacctcct agtgtctgtt agcattcctt ttcatggggg gagggaagat 3420 aaagtgaatt gcccagagct gcctttttct tttcttttta aaaattttaa gaagttttcc 3480 ttgtggggct ggggaggggc cggggtcagg gagagtcttt tttttttttt ttttaaatac 3540 taaattggaa catttaattc catattaata caaggggttt gaactggaca tcctaatgat 3600 gcaattacgt catcacccag ctgattccgg gtggttggca aactcatcgt gtctgtcctg 3660 agaggctcca caatgcccac ccgcatcgcc attctgtagt cttcagggtc agctgttgat 3720 aaaggggcag gcttgcgtta ttggcctaga ttttgctgca gattaaatcc tttgaggatt 3780 ctcttctctt ttaccatttt tctgcgtgct ctcactctct ctttctctct ctagcttttt 3840 aattcatgaa tattttcgtg tctgtctctc tctctctctg tgtttcctcc agcccttgtc 3900 tcggagacgg tgttttcctc ccttgcccca ttatcttttc acctcccagg tctacatttc 3960 atggtggtcg ttgggtccgc ctaaaggatt tgagcgtttg ccattgcaag catagtgctg 4020 tgtcatcctg gtccatgtag gactggtgct aaccacctgc catcatgagg atgtgtgcta 4080 gagtgtggga ccctggccaa gtgcaggaat gggccatgcc gtctcaccca cagtatcaca 4140 cgtggaaccg cagacagggc ccagaagctt tagaggtatg aggctgcaga accggagaga 4200 ttttcctctg tgcagtgctc tctggctaaa gtcacggtca aacctaaaca ccgagcctca 4260 ttaacccaag tgaaccaacc aaagtcacca gttcagaagt gctaagctaa taggagtctg 4320 acccgagggc ctgctgcttc ctggttaagt atcttttgag attctagaac acatgggagc 4380 tttttatttt cggggaaaaa ccgtattttt ttcttgtcca attatttcta aagacacact 4440 acatagaaag aggccctata aactcaaaaa gtcattggga aacttaaagt ctattctact 4500 ttgccaagag gagaaatgtg ttttatgaac gatagatcac atcagaactc ctgtggggag 4560 gaaaccttat aaattaaaca catggccccc ttagagacca caggcgatgt ctgtctccat 4620 ccttccctct ccttttctgt cacctttccc cctagctggc tcctttggac ctacccctgt 4680 ccttgctgac ttgtgttgca ttgtattcca aacgtgttta caggttctct taagcaatgt 4740 tgtatttgca ggcttttctg aataccaaat ctgctttttg taaagcgtaa aaacatcaca 4800 aagtaggtca ttccatcacc acccttgtct ctctacacat tttgcctttg gggatctggt 4860 tggggttttg ggttttttgt tgttgttgtt tatttgttat tttaaaggta aattgcactt 4920 ttaaaaaaat aattggttga cttaatatat ttgctttttt tctcacctgc acttagagga 4980 aatttgaaca agttggaaaa aaacaatttt tgtttcaatt ctaagaaaca cttgcagctc 5040 tagtattcac ttgagtcttc ctgtttttcc tgtaccgggt catggtaatt tttggttgtt 5100 ttggttgttt tcttaaaaaa caagttaaaa cctgacgatt tctgcagtga cttgatgctc 5160 taaaacagtg taggatttaa gaatagatgg tttttaatcc tggaaattgt gattgtgacc 5220 catgagtgga ggaactttca gttctaaagc tgataaagtg tgtagccaga agagtacttt 5280 ttttttgtaa ccactgtctt gatggcaaaa taattatggt aaaaaacaag tctcgtgttt 5340 attattcctt aagaactctg tgttatatta ccatggaacg cctaataaag caaaatgtgg 5400 ttgtttcaaa aaaaaaaaaa a 5421 <210> 95 <211> 1670 <212> DNA <213> Homo sapiens <400> 95 cggcacgagg caagtgacgc cgagggcctg agtgctccag tagccaccgc atctggagaa 60 ccagcggtta ccatggaggg gatcagtata tacacttcag ataactacac cgaggaaatg 120 ggctcagggg actatgactc catgaaggaa ccctgtttcc gtgaagaaaa tgctaatttc 180 aataaaatct tcctgcccac catctactcc atcatcttct taactggcat tgtgggcaat 240 ggattggtca tcctggtcat gggttaccag aagaaactga gaagcatgac ggacaagtac 300 aggctgcacc tgtcagtggc cgacctcctc tttgtcatca cgcttccctt ctgggcagtt 360 gatgccgtgg caaactggta ctttgggaac ttcctatgca aggcagtcca tgtcatctac 420 acagtcaacc tctacagcag tgtcctcatc ctggccttca tcagtctgga ccgctacctg 480 gccatcgtcc acgccaccaa cagtcagagg ccaaggaagc tgttggctga aaaggtggtc 540 tatgttggcg tctggatccc tgccctcctg ctgactattc ccgacttcat ctttgccaac 600 gtcagtgagg cagatgacag atatatctgt gaccgcttct accccaatga cttgtgggtg 660 gttgtgttcc agtttcagca catcatggtt ggccttatcc tgcctggtat tgtcatcctg 720 tcctgctatt gcattatcat ctccaagctg tcacactcca agggccacca gaagcgcaag 780 gccctcaaga ccacagtcat cctcatcctg gctttcttcg cctgttggct gccttactac 840 attgggatca gcatcgactc cttcatcctc ctggaaatca tcaagcaagg gtgtgagttt 900 gagaacactg tgcacaagtg gatttccatc accgaggccc tagctttctt ccactgttgt 960 ctgaacccca tcctctatgc tttccttgga gccaaattta aaacctctgc ccagcacgca 1020 ctcacctctg tgagcagagg gtccagcctc aagatcctct ccaaaggaaa gcgaggtgga 1080 cattcatctg tttccactga gtctgagtct tcaagttttc actccagcta acacagatgt 1140 aagagacttt tttttatacg ataaataact tttttttaag ttacacattt ttcagatata 1200 aaagactgac caatattgta cagtttttat tgcttgttgg atttttgctc ttgtgtttct 1260 ttagtttttc gtgaaggttt aattgactta tttatataaa ttttttttgt ttcatattga 1320 tgtgtgtcta ggcaggacct gtggccaagt tcttagttgc tgtatgtctc gtggtaggac 1380 tgtagaaaag ggaactgaac attccagagc gtgtagtgaa tcacgtaaag ctagaaatga 1440 tccccagctg tttatgcata gataatctct ccattcccgt ggaacgtttt tcctgttctt 1500 aagacgtgat tttgctgtag aagatggcac ttataaccaa agcccaaagt ggtatagaaa 1560 tgctggtttt tcagttttca ggagtgggtt gatttcagca cctacagtgt acagtcttgt 1620 attaagttgt taataaaagt acatgttaaa cttaaaaaaa aaaaaaaaaa 1670 <210> 96 <211> 8287 <212> DNA <213> Homo sapiens <400> 96 ctgattatga agtgcctcag agccaaccta ttaagcttgg agatcatctc aacagcatac 60 tgcttggaat gtgtgaggat gttatttacg ctcgagtttc tgttcggact gtgctggatg 120 cttgcagtgc ccacattagg aatagcaatt gtgcaccctc attttcctac gtgaaacact 180 tggtaaaact ggttctggga aatctttctg gggtaatatg cacgtgtcac tagctgaggc 240 cctggaggtt cggggtggac cacttcagga ggaagaaata tgggctgtat taaatcaaag 300 tgctgaaagt ctccaagaat tattcagaaa agtaagccta gctgatcctg ctgcccttgg 360 cttcatcatt tctccatggt ctctgctgtt gctgccatct ggtagtgtgt catttacaga 420 tgaaaatatt tccaatcagg atcttcgagc attcactgca ccagaggttc ttcaaaatca 480 gtcactaact tctctctcag atgttgaaaa gatccacatt tattctcttg gaatgacact 540 gtattggggg gctgattatg aagtgcctca gagccaacct attaagcttg gagatcatct 600 caacagcata ctgcttggaa tgtgtgagga tgttatttac gctcgagttt ctgttcggac 660 tgtgctggat gcttgcagtg cccacattag gaatagcaat tgtgcaccct cattttccta 720 cgtgaaacac ttggtaaaac tggttctggg aaatctttct gggacagatc agctttcctg 780 taacagtgaa caaaagcctg atcgaagcca ggctattcga gatcgattgc gaggaaaagg 840 attaccaaca ggaagaagct ctacttctga tgtactagac atacaaaagc ctccactctc 900 tcatcagacc tttcttaaca aagggcttag taaatctatg ggatttctgt ccatcaaaga 960 tacacaagat gagaattatt tcaaggacat tttatcagat aattctggac gtgaagattc 1020 tgaaaataca ttctcccctt accagttcaa aactagtggc ccagaaaaaa aacccatccc 1080 tggcattgat gtgctttcta agaagaagat ctgggcttca tccatggact tgctttgtac 1140 agctgacaga gacttctctt caggagagac tgccacatat cgtcgttgtc accctgaggc 1200 agtaacagtg cggacttcaa ctactcctag aaaaaaggag gcaagatact cagatggaag 1260 tatagccttg gatatctttg gccctcagaa aatggatcca atatatcaca ctcgagaatt 1320 gcccacctcc tcagcaatat caagtgcttt ggaccgaatc cgagagagac aaaagaaact 1380 tcaggttctg agggaagcca tgaatgtaga agaaccagtt cgaagataca aaacttatca 1440 tggtgatgtc tttagtacct ccagtgaaag tccatctatt atttcctctg aatcagattt 1500 cagacaagtg agaagaagtg aagcctcaaa gaggtttgaa tccagcagtg gtctcccagg 1560 ggtagatgaa accttaagtc aaggccagtc acagagaccg agcagacaat atgaaacacc 1620 ctttgaaggc aacttaatta atcaagagat catgctaaaa cggcaagagg aagaactgat 1680 gcagctacaa gccaaaatgg cccttagaca gtctcggttg agcctatatc caggagacac 1740 aatcaaagcg tccatgcttg acatcaccag ggatccgtta agagaaattg ccctagaaac 1800 agccatgact caaagaaaac tgaggaattt ctttggccct gagtttgtga aaatgacaat 1860 tgaaccattt atatctttgg atttgccacg gtctattctt actaagaaag ggaagaatga 1920 ggataaccga aggaaagtaa acataatgct tctgaacggg caaagactgg aactgacctg 1980 tgataccaaa actatatgta aagatgtgtt tgatatggtt gtggcacata ttggcttagt 2040 agagcatcat ttgtttgctt tagctaccct caaagataat gaatatttct ttgttgatcc 2100 tgacttaaaa ttaaccaaag tggccccaga gggatggaaa gaagaaccaa agaaaaagac 2160 caaagccact gttaatttta ctttgttttt cagaattaaa ttttttatgg atgatgttag 2220 tctaatacaa catactctga cgtgtcatca gtattacctt cagcttcgaa aagatatttt 2280 ggaggaaagg atgcactgtg atgatgagac ttccttattg ctggcatcct tggctctcca 2340 ggctgagtat ggagattatc aaccagaggt tcatggtgtg tcttacttta gaatggagca 2400 ctatttgccc gccagagtga tggagaaact tgatttatcc tatatcaaag aagagttacc 2460 caaattgcat aatacctatg tgggagcttc tgaaaaagag acagagttag aatttttaaa 2520 ggtctgccaa agactgacag aatatggagt tcattttcac cgagtgcacc ctgagaagaa 2580 gtcacaaaca ggaatattgc ttggagtctg ttctaaaggt gtccttgtgt ttgaagttca 2640 caatggagtg cgcacattgg tccttcgctt tccatggagg gaaaccaaga aaatatcttt 2700 ttctaaaaag aaaatcacat tgcaaaatac atcagatgga ataaaacatg gcttccagac 2760 agacaacagt aagatatgcc agtacctgct gcacctctgc tcttaccagc ataagttcca 2820 gctacagatg agagcaagac agagcaacca agatgcccaa gatattgaga gagcttcgtt 2880 taggagcctg aatctccaag cagagtctgt tagaggattt aatatgggac gagcaatcag 2940 cactggcagt ctggccagca gcaccctcaa caaacttgct gttcgacctt tatcagttca 3000 agctgagatt ctgaagaggc tatcctgctc agagctgtcg ctttaccagc cattgcaaaa 3060 cagttcaaaa gagaagaatg acaaagcttc atgggaggaa aagcctagag agatgagtaa 3120 atcataccat gatctcagtc aggcctctct ctatccacat cggaaaaatg tcattgttaa 3180 catggaaccc ccaccacaaa ccgttgcaga gttggtggga aaaccttctc accagatgtc 3240 aagatctgat gcagaatctt tggcaggagt gacaaaactt aataattcaa agtctgttgc 3300 gagtttaaat agaagtcctg aaaggaggaa acatgaatca gactcctcat ccattgaaga 3360 ccctgggcaa gcatatgttc taggaatgac tatgcatagt tctggaaact cttcatccca 3420 agtaccctta aaagaaaatg atgtgctaca caaaagatgg agcatagtat cttcaccaga 3480 aagggagatc accttagtga acctgaaaaa agatgcaaag tatggcttgg gatttcaaat 3540 tattggtggg gagaagatgg gaagactgga cctaggcata tttatcagtt cagttgcccc 3600 tggaggacca gctgacttgg atggatgctt gaagccagga gaccgtttga tatctgtgaa 3660 tagtgtgagt ctggagggag tcagccacca tgctgcaatt gaaattttgc aaaatgcacc 3720 tgaagatgtg acacttgtta tctctcagcc aaaagaaaag atatccaaag tgccttctac 3780 tcctgtgcat ctcaccaatg agatgaaaaa ctacatgaag aaatcttcct acatgcaaga 3840 cagtgctata gattcttctt ccaaggatca ccactggtca cgtggtaccc tgaggcacat 3900 ctcggagaac tcctttgggc cgtctggggg cctgcgggaa ggaagcctga gttctcaaga 3960 ttccaggact gagagtgcca gcttgtctca aagccaggtc aatggtttct ttgccagcca 4020 tttaggtgac caaacctggc aggaatcaca gcatggcagc ccttccccat ctgtaatatc 4080 caaagccacc gagaaagaga ctttcactga tagtaaccaa agcaaaacta aaaagccagg 4140 catttctgat gtaactgatt actcagaccg tggagattca gacatggatg aagccactta 4200 ctccagcagt caggatcatc aaacaccaaa acaggaatct tcctcttcag tgaatacatc 4260 caacaagatg aattttaaaa ctttttcttc atcacctcct aagcctggag atatctttga 4320 ggttgaactg gctaaaaatg ataacagctt ggggataagt gtcacggtac tgtttgacaa 4380 gggaggtgtg aatacgagtg tcagacatgg tggcatttat gtgaaagctg ttattcccca 4440 gggagcagca gagtctgatg gtagaattca caaaggtgat cgcgtcctag ctgtcaatgg 4500 agttagtcta gaaggagcca cccataagca agctgtggaa acactgagaa atacaggaca 4560 ggtggttcat ctgttattag aaaagggaca atctccaaca tctaaagaac atgtcccggt 4620 aaccccacag tgtacccttt cagatcagaa tgcccaaggt caaggcccag aaaaagtgaa 4680 gaaaacaact caggtcaaag actacagctt tgtcactgaa gaaaatacat ttgaggtaaa 4740 attatttaaa aatagctcag gtctaggatt cagtttttct cgagaagata atcttatacc 4800 ggagcaaatt aatgccagca tagtaagggt taaaaagctc tttcctggac agccagcagc 4860 agaaagtgga aaaattgatg taggagatgt tatcttgaaa gtgaatggag cctctttgaa 4920 aggactatct cagcaggaag tcatatctgc tctcagggga actgctccag aagtattctt 4980 gcttctctgc agacctccac ctggtgtgct accggaaatt gatactgcgc ttttgacccc 5040 acttcagtct ccagcacaag tacttccaaa cagcagtaaa gactcttctc agccatcatg 5100 tgtggagcaa agcaccagct cagatgaaaa tgaaatgtca gacaaaagca aaaaacagtg 5160 caagtcccca tccagaagag acagttacag tgacagcagt gggagtggag aagatgactt 5220 agtgacagct ccagcaaaca tatcaaattc gacctggagt tcagctttgc atcagactct 5280 aagcaacatg gtatcacagg cacagagtca tcatgaagca cccaagagtc aagaagatac 5340 catttgtacc atgttttact atcctcagaa aattcccaat aaaccagagt ttgaggacag 5400 taatccttcc cctctaccac cggatatggc tcctgggcag agttatcaac cccaatcaga 5460 atctgcttcc tctagttcga tggataagta tcatatacat cacatttctg aaccaactag 5520 acaagaaaac tggacacctt tgaaaaatga cttggaaaat caccttgaag actttgaact 5580 ggaagtagaa ctcctcatta ccctaattaa atcagaaaaa ggaagcctgg gttttacagt 5640 aaccaaaggc aatcagagaa ttggttgtta tgttcatgat gtcatacagg atccagccaa 5700 aagtgatgga aggctaaaac ctggggaccg gctcataaag gttaatgata cagatgttac 5760 taatatgact catacagatg cagttaatct gctccgggct gcatccaaaa cagtcagatt 5820 agttattgga cgagttctag aattacccag aataccaatg ttgcctcatt tgctaccgga 5880 cataacacta acgtgcaaca aagaggagtt gggtttttcc ttatgtggag gtcatgacag 5940 cctttatcaa gtggtatata ttagtgatat taatccaagg tccgtcgcag ccattgaggg 6000 taatctccag ctattagatg tcatccatta tgtgaacgga gtcagcacac aaggaatgac 6060 cttggaggaa gttaacagag cattagacat gtcacttcct tcattggtat tgaaagcaac 6120 aagaaatgat cttccagtgg tccccagctc aaagaggtct gctgtttcag ctccaaagtc 6180 aaccaaaggc aatggttcct acagtgtggg gtcttgcagc cagcctgccc tcactcctaa 6240 tgattcattc tccacggttg ctggggaaga aataaatgaa atatcgtacc ccaaaggaaa 6300 atgttctact tatcagataa agggatcacc aaacttgact ctgcccaaag aatcttatat 6360 acaagaagat gacatttatg atgattccca agaagctgaa gttatccagt ctctgctgga 6420 tgttgtggat gaggaagccc agaatctttt aaacgaaaat aatgcagcag gatactcctg 6480 tggtccaggt acattaaaga tgaatgggaa gttatcagaa gagagaacag aagatacaga 6540 ctgcgatggt tcacctttac ctgagtattt tactgaggcc accaaaatga atggctgtga 6600 agaatattgt gaagaaaaag taaaaagtga aagcttaatt cagaagccac aagaaaagaa 6660 gactgatgat gatgaaataa catggggaaa tgatgagttg ccaatagaga gaacaaacca 6720 tgaagattct gataaagatc attcctttct gacaaacgat gagctcgctg tactccctgt 6780 cgtcaaagtg cttccctctg gtaaatacac gggtgccaac ttaaaatcag tcattcgagt 6840 cctgcggggt ttgctagatc aaggaattcc ttctaaggag ctggagaatc ttcaagaatt 6900 aaaacctttg gatcagtgtc taattgggca aactaaggaa aacagaagga agaacagata 6960 taaaaatata cttccctatg atgctacaag agtgcctctt ggagatgaag gtggctatat 7020 caatgccagc ttcattaaga taccagttgg gaaagaagag ttcgtttaca ttgcctgcca 7080 aggaccactg cctacaactg ttggagactt ctggcagatg atttgggagc aaaaatccac 7140 agtgatagcc atgatgactc aagaagtaga aggagaaaaa atcaaatgcc agcgctattg 7200 gcccaacatc ctaggcaaaa caacaatggt cagcaacaga cttcgactgg ctcttgtgag 7260 aatgcagcag ctgaagggct ttgtggtgag ggcaatgacc cttgaagata ttcagaccag 7320 agaggtgcgc catatttctc atctgaattt cactgcctgg ccagaccatg atacaccttc 7380 tcaaccagat gatctgctta cttttatctc ctacatgaga cacatccaca gatcaggccc 7440 aatcattacg cactgcagtg ctggcattgg acgttcaggg accctgattt gcatagatgt 7500 ggttctggga ttaatcagtc aggatcttga ttttgacatc tctgatttgg tgcgctgcat 7560 gagactacaa agacacggaa tggttcagac agaggatcaa tatattttct gctatcaagt 7620 catcctttat gtcctgacac gtcttcaagc agaagaagag caaaaacagc agcctcagct 7680 tctgaagtga catgaaaaga gcctctggat gcatttccat ttctctcctt aacctccagc 7740 agactcctgc tctctatcca aaataagatc acagagcagc aagttcatac aacatgcatg 7800 ttctcctcta tcttagaggg gtattcttct tgaaaataaa aaatattgaa atgctgtatt 7860 tttacagcta ctttaaccta tgataattat ttacaaaatt ttaacactaa ccaaacaatg 7920 cagatcttag ggatgattaa aggcagcatt tgatgatagc agacattgtt acaaggacat 7980 ggtgagtcta tttttaatgc accaatcttg tttatagcaa aaatgttttc caatatttta 8040 ataaagtagt tattttatag gggatacttg aaaccagtat ttaagcttta aatgacagta 8100 atattggcat agaaaaaagt agcaaatgtt tactgtatca atttctaatg tttactatat 8160 agaatttcct gtaatatatt tatatacttt ttcatgaaaa tggagttatc agttatctgt 8220 ttgttactgc atcatctgtt tgtaatcatt atctcacttt gtaaataaaa acacacctta 8280 aaacatg 8287 <210> 97 <211> 364 <212> DNA <213> Homo sapiens <400> 97 gcacgagagt acatatcatt aaaccatttt ctctaaatgt aagaagagca gaaaaaatct 60 tataagatta tcagattttt ctaatgacac agaaatgtaa gaagaaaatc cctttatatt 120 gaaaaaagat gcagtcaaag tcttttcaga catgcccaaa ctttgagaat tccttcaacc 180 atctaatgct ataaagattt ttgttcttcc tgttcacaac cagttgtata acagaaatac 240 tagctactgt tttccttcct gtgtgtgaag taatgaatca ttgattatgt gacttgttat 300 gtattcaatt aaacactaaa gaataaaaca ttcactcctt taaaaaaaaa aaaaataaaa 360 aaaa 364 <210> 98 <211> 729 <212> DNA <213> Homo sapiens <400> 98 gaattcggga gcatggacct cagtcttctc tgggtactta tgcccctagt caccatggcc 60 tggggccagt atggcgatta tggataccca taccagcagt atcatgacta cagcgatgat 120 gggtgggtga atttgaatcg gcaaggcttc agctaccagt gtccccaggg gcaggtgata 180 gtggccgtga ggagcatctt cagtaagaag gaaggttctg acagacaatg gaactacgcc 240 tgcatgccca cgccacagag cctcggggaa cccacggagt gctggtggga ggagatcaac 300 agggctggca tggaatggta ccagacgtgc tccaacaatg ggctggtggc aggattccag 360 agccgctact tcgagtcagt gctggatcgg gagtggcagt tttactgttg tcgctacagc 420 aagaggtgcc catattcctg ctggctaaca acagaatatc caggtcacta tggtgaggaa 480 atggacatga tttcctacaa ttatgattac tatatccgag gagcaacaac cactttctct 540 gcagtggaaa gggatcgcca gtggaagttc ataatgtgcc ggatgactga atacgactgt 600 gaatttgcaa atgtttagat ttgccacata ccaaatctgg gtgaaaggaa aggggccctc 660 cagctttcca ctgcagagaa agtggttgtt gctcctcggt atatgtaatc ataattgtag 720 atcgaattc 729 <210> 99 <211> 303 <212> DNA <213> Homo sapiens <400> 99 gtttattcat atcttctgga ctgagcagcc gcctccgttt gattagaagc gcttgttcac 60 acatatttac acacccgctt ctggcgccca cggccggaac cgccagaggc cagaaggcga 120 ggcttggcga gttttgtgtg cttttgggta acgcacgacc agtactggaa gagatcaggg 180 gtagcctgga agaggggctc ctgcaggtaa tcgtacactt catttttgcc tagccgatca 240 tcttccatgg ccaccgtcct gctgtctata tcaaccaaca ccttttctgg ggtctgatga 300 gcg 303 <210> 100 <211> 429 <212> DNA <213> Homo sapiens <400> 100 tttttttttg caatcctcaa accgtttatt gacagcacaa ggctcaacag caggtgagcc 60 acgtgagggt ggcgagcgct tgcgaggcag tgtgggcacc aggcagggga tcccggaggg 120 aagccctctg ccagggacat ggtgagggcg tggccatcac ccacgaaggg agcataaata 180 acactggcag gtgggtgttc actcccttgg gtccgaagag gattccatag cagggcttgt 240 ggcagtaggg ctggccgtcg tgctccgcgt gcccgccggg ggtcagtgtc ttcccgcagc 300 gctcgcagcg caggcagggc cggtgccaat ccttgcccag agacgtcacc ttctcagcga 360 agtacacctt cttgctgcag cgcgggcacg tgttgggctc cccggtgaaa gtggtgacac 420 tggaggctc 429 <210> 101 <211> 832 <212> DNA <213> Homo sapiens <400> 101 atggtccagc agtcgttccc agcagaacag cggagcctgg actgacaccc agtgggacca 60 gtgttgccac accagttgat aaaatgcaga aacccttctg tactcgttgg taaatatcta 120 ctcccccaag tgactccagg tgccccccac cgcctggcac ttcccccagg actcctacga 180 tctggttact gcctggccga tccaaggctg tggagtccca gagccagcag ttcactggtg 240 ctcattccac actggttaga tacttcagtt gtcacccctg ggaagattct cccacctcct 300 ccctttgatg gaaccaccct ccccagaggc tgcattgagg agactccaca gactgaaaag 360 tgagtttgca gaaaccttgg ggaaaagggc cctttcaaag aagtggataa gagggaggag 420 atcattgagt gacccagaaa gctcttttga aaagacagac tcctcaagga gagataaaga 480 ggaaagcacc tctttcattt tttagtgtga gctaattcca tcagactgct gtcctcctgg 540 acccatctga gatggcagta gcaaggagag gggggatcat tttagagagt gggtcattgg 600 cagggagtgc tccggaggga ggcagagggg agactgtggt agaaggaaga cagaactcac 660 acatgctccc aggattgggg acagggacag aggaggtaac agaaggcaaa ggccagtttc 720 cccgttatca tgaaggggcc cactcaggac aggaacaagg acaactcctc ctcctcctcc 780 tcctctcctg ctgctcctgg gatacccagg tcagtgatgt agtcttgcag tt 832 <210> 102 <211> 6378 <212> DNA <213> Homo sapiens <400> 102 cccattactg ttggagctac agggagagaa acaggaggag actgcaagag atcatttggg 60 aaggccgtgg gcacgctctt tactccatgt gtgggacatt cattgcggaa taacatcgga 120 ggagaagttt cccagagcta tggggacttc ccatccggcg ttcctggtct taggctgtct 180 tctcacaggg ctgagcctaa tcctctgcca gctttcatta ccctctatcc ttccaaatga 240 aaatgaaaag gttgtgcagc tgaattcatc cttttctctg agatgctttg gggagagtga 300 agtgagctgg cagtacccca tgtctgaaga agagagctcc gatgtggaaa tcagaaatga 360 agaaaacaac agcggccttt ttgtgacggt cttggaagtg agcagtgcct cggcggccca 420 cacagggttg tacacttgct attacaacca cactcagaca gaagagaatg agcttgaagg 480 caggcacatt tacatctatg tgccagaccc agatgtagcc tttgtacctc taggaatgac 540 ggattattta gtcatcgtgg aggatgatga ttctgccatt ataccttgtc gcacaactga 600 tcccgagact cctgtaacct tacacaacag tgagggggtg gtacctgcct cctacgacag 660 cagacagggc tttaatggga ccttcactgt agggccctat atctgtgagg ccaccgtcaa 720 aggaaagaag ttccagacca tcccatttaa tgtttatgct ttaaaagcaa catcagagct 780 ggatctagaa atggaagctc ttaaaaccgt gtataagtca ggggaaacga ttgtggtcac 840 ctgtgctgtt tttaacaatg aggtggttga ccttcaatgg acttaccctg gagaagtgaa 900 aggcaaaggc atcacaatgc tggaagaaat caaagtccca tccatcaaat tggtgtacac 960 tttgacggtc cccgaggcca cggtgaaaga cagtggagat tacgaatgtg ctgcccgcca 1020 ggctaccagg gaggtcaaag aaatgaagaa agtcactatt tctgtccatg agaaaggttt 1080 cattgaaatc aaacccacct tcagccagtt ggaagctgtc aacctgcatg aagtcaaaca 1140 ttttgttgta gaggtgcggg cctacccacc tcccaggata tcctggctga aaaacaatct 1200 gactctgatt gaaaatctca ctgagatcac cactgatgtg gaaaagattc aggaaataag 1260 gtatcgaagc aaattaaagc tgatccgtgc taaggaagaa gacagtggcc attatactat 1320 tgtagctcaa aatgaagatg ctgtgaagag ctatactttt gaactgttaa ctcaagttcc 1380 ttcatccatt ctggacttgg tcgatgatca ccatggctca actgggggac agacggtgag 1440 gtgcacagct gaaggcacgc cgcttcctga tattgagtgg atgatatgca aagatattaa 1500 gaaatgtaat aatgaaactt cctggactat tttggccaac aatgtctcaa acatcatcac 1560 ggagatccac tcccgagaca ggagtaccgt ggagggccgt gtgactttcg ccaaagtgga 1620 ggagaccatc gccgtgcgat gcctggctaa gaatctcctt ggagctgaga accgagagct 1680 gaagctggtg gctcccaccc tgcgttctga actcacggtg gctgctgcag tcctggtgct 1740 gttggtgatt gtgatcatct cacttattgt cctggttgtc atttggaaac agaaaccgag 1800 gtatgaaatt cgctggaggg tcattgaatc aatcagcccg gatggacatg aatatattta 1860 tgtggacccg atgcagctgc cttatgactc aagatgggag tttccaagag atggactagt 1920 gcttggtcgg gtcttggggt ctggagcgtt tgggaaggtg gttgaaggaa cagcctatgg 1980 attaagccgg tcccaacctg tcatgaaagt tgcagtgaag atgctaaaac ccacggccag 2040 atccagtgaa aaacaagctc tcatgtctga actgaagata atgactcacc tggggccaca 2100 tttgaacatt gtaaacttgc tgggagcctg caccaagtca ggccccattt acatcatcac 2160 agagtattgc ttctatggag atttggtcaa ctatttgcat aagaataggg atagcttcct 2220 gagccaccac ccagagaagc caaagaaaga gctggatatc tttggattga accctgctga 2280 tgaaagcaca cggagctatg ttattttatc ttttgaaaac aatggtgact acatggacat 2340 gaagcaggct gatactacac agtatgtccc catgctagaa aggaaagagg tttctaaata 2400 ttccgacatc cagagatcac tctatgatcg tccagcctca tataagaaga aatctatgtt 2460 agactcagaa gtcaaaaacc tcctttcaga tgataactca gaaggcctta ctttattgga 2520 tttgttgagc ttcacctatc aagttgcccg aggaatggag tttttggctt caaaaaattg 2580 tgtccaccgt gatctggctg ctcgcaacgt cctcctggca caaggaaaaa ttgtgaagat 2640 ctgtgacttt ggcctggcca gagacatcat gcatgattcg aactatgtgt cgaaaggcag 2700 tacctttctg cccgtgaagt ggatggctcc tgagagcatc tttgacaacc tctacaccac 2760 actgagtgat gtctggtctt atggcattct gctctgggag atcttttccc ttggtggcac 2820 cccttacccc ggcatgatgg tggattctac tttctacaat aagatcaaga gtgggtaccg 2880 gatggccaag cctgaccacg ctaccagtga agtctacgag atcatggtga aatgctggaa 2940 cagtgagccg gagaagagac cctcctttta ccacctgagt gagattgtgg agaatctgct 3000 gcctggacaa tataaaaaga gttatgaaaa aattcacctg gacttcctga agagtgacca 3060 tcctgctgtg gcacgcatgc gtgtggactc agacaatgca tacattggtg tcacctacaa 3120 aaacgaggaa gacaagctga aggactggga gggtggtctg gatgagcaga gactgagcgc 3180 tgacagtggc tacatcattc ctctgcctga cattgaccct gtccctgagg aggaggacct 3240 gggcaagagg aacagacaca gctcgcagac ctctgaagag agtgccattg agacgggttc 3300 cagcagttcc accttcatca agagagagga cgagaccatt gaagacatcg acatgatgga 3360 cgacatcggc atagactctt cagacctggt ggaagacagc ttcctgtaac tggcggattc 3420 gaggggttcc ttccacttct ggggccacct ctggatcccg ttcagaaaac cactttattg 3480 caatgcggag gttgagagga ggacttggtt gatgtttaaa gagaagttcc cagccaaggg 3540 cctcggggag cgttctaaat atgaatgaat gggatatttt gaaatgaact ttgtcagtgt 3600 tgcctctcgc aatgcctcag tagcatctca gtggtgtgtg aagtttggag atagatggat 3660 aagggaataa taggccacag aaggtgaact ttgtgcttca aggacattgg tgagagtcca 3720 acagacacaa tttatactgc gacagaactt cagcattgta attatgtaaa taactctaac 3780 caaggctgtg tttagattgt attaactatc ttctttggac ttctgaagag accactcaat 3840 ccatccatgt acttccctct tgaaacctga tgtcagctgc tgttgaactt tttaaagaag 3900 tgcatgaaaa accatttttg aaccttaaaa ggtactggta ctatagcatt ttgctatctt 3960 ttttagtgtt aagagataaa gaataataat taaccaacct tgtttaatag atttgggtca 4020 tttagaagcc tgacaactca ttttcatatt gtaatctatg tttataatac tactactgtt 4080 atcagtaatg ctaaatgtgt aataatgtaa catgatttcc ctccagagaa agcacaattt 4140 aaaacaatcc ttactaagta ggtgatgagt ttgacagttt ttgacattta tattaaataa 4200 catgtttctc tataaagtat ggtaatagct ttagtgaatt aaatttagtt gagcatagag 4260 aacaaagtaa aagtagtgtt gtccaggaag tcagaatttt taactgtact gaataggttc 4320 cccaatccat cgtattaaaa aacaattaac tgccctctga aataatggga ttagaaacaa 4380 acaaaactct taagtcctaa aagttctcaa tgtagaggca taaacctgtg ctgaacataa 4440 cttctcatgt atattaccca atggaaaata taatgatcag caaaaagact ggatttgcag 4500 aagttttttt tttttttctt catgcctgat gaaagctttg gcaaccccaa tatatgtatt 4560 ttttgaatct atgaacctga aaagggtcag aaggatgccc agacatcagc ctccttcttt 4620 caccccttac cccaaagaga aagagtttga aactcgagac cataaagata ttctttagtg 4680 gaggctggat gtgcattagc ctggatcctc agttctcaaa tgtgtgtggc agccaggatg 4740 actagatcct gggtttccat ccttgagatt ctgaagtatg aagtctgagg gaaaccagag 4800 tctgtatttt tctaaactcc ctggctgttc tgatcggcca gttttcggaa acactgactt 4860 aggtttcagg aagttgccat gggaaacaaa taatttgaac tttggaacag ggttggaatt 4920 caaccacgca ggaagcctac tatttaaatc cttggcttca ggttagtgac atttaatgcc 4980 atctagctag caattgcgac cttaatttaa ctttccagtc ttagctgagg ctgagaaagc 5040 taaagtttgg ttttgacagg ttttccaaaa gtaaagatgc tacttcccac tgtatggggg 5100 agattgaact ttccccgtct cccgtcttct gcctcccact ccataccccg ccaaggaaag 5160 gcatgtacaa aaattatgca attcagtgtt ccaagtctct gtgtaaccag ctcagtgttt 5220 tggtggaaaa aacattttaa gttttactga taatttgagg ttagatggga ggatgaattg 5280 tcacatctat ccacactgtc aaacaggttg gtgtgggttc attggcattc tttgcaatac 5340 tgcttaattg ctgataccat atgaatgaaa catgggctgt gattactgca atcactgtgc 5400 tatcggcaga tgatgctttg gaagatgcag aagcaataat aaagtacttg actacctact 5460 ggtgtaatct caatgcaagc cccaactttc ttatccaact ttttcatagt aagtgcgaag 5520 actgagccag attggccaat taaaaacgaa aacctgacta ggttctgtag agccaattag 5580 acttgaaata cgtttgtgtt tctagaatca cagctcaagc attctgttta tcgctcactc 5640 tcccttgtac agccttattt tgttggtgct ttgcattttg atattgctgt gagccttgca 5700 tgacatcatg aggccggatg aaacttctca gtccagcagt ttccagtcct aacaaatgct 5760 cccacctgaa tttgtatatg actgcatttg tgggtgtgtg tgtgttttca gcaaattcca 5820 gatttgtttc cttttggcct cctgcaaagt ctccagaaga aaatttgcca atctttccta 5880 ctttctattt ttatgatgac aatcaaagcc ggcctgagaa acactatttg tgacttttta 5940 aacgattagt gatgtcctta aaatgtggtc tgccaatctg tacaaaatgg tcctattttt 6000 gtgaagaggg acataagata aaatgatgtt atacatcaat atgtatatat gtatttctat 6060 atagacttgg agaatactgc caaaacattt atgacaagct gtatcactgc cttcgtttat 6120 atttttttaa ctgtgataat ccccacaggc acattaactg ttgcactttt gaatgtccaa 6180 aatttatatt ttagaaataa taaaaagaaa gatacttaca tgttcccaaa acaatggtgt 6240 ggtgaatgtg tgagaaaaac taacttgata gggtctacca atacaaaatg tattacgaat 6300 gcccctgttc atgtttttgt tttaaaacgt gtaaatgaag atctttatat ttcaataaat 6360 gatatataat ttaaagtt 6378 <210> 103 <211> 3794 <212> DNA <213> Homo sapiens <400> 103 ccaagttcta cctcatgttt ggaggatctt gctagctatg gccctcgtac tcggctccct 60 gttgctgctg gggctgtgcg ggaactcctt ttcaggaggg cagccttcat ccacagatgc 120 tcctaaggct tggaattatg aattgcctgc aacaaattat gagacccaag actcccataa 180 agctggaccc attggcattc tctttgaact agtgcatatc tttctctatg tggtacagcc 240 gcgtgatttc ccagaagata ctttgagaaa attcttacag aaggcatatg aatccaaaat 300 tgattatgac aagccagaaa ctgtaatctt aggtctaaag attgtctact atgaagcagg 360 gattattcta tgctgtgtcc tggggctgct gtttattatt ctgatgcctc tggtggggta 420 tttcttttgt atgtgtcgtt gctgtaacaa atgtggtgga gaaatgcacc agcgacagaa 480 ggaaaatggg cccttcctga ggaaatgctt tgcaatctcc ctgttggtga tttgtataat 540 aataagcatt ggcatcttct atggttttgt ggcaaatcac caggtaagaa cccggatcaa 600 aaggagtcgg aaactggcag atagcaattt caaggacttg cgaactctct tgaatgaaac 660 tccagagcaa atcaaatata tattggccca gtacaacact accaaggaca aggcgttcac 720 agatctgaac agtatcaatt cagtgctagg aggcggaatt cttgaccgac tgagacccaa 780 catcatccct gttcttgatg agattaagtc catggcaaca gcgatcaagg agaccaaaga 840 ggcgttggag aacatgaaca gcaccttgaa gagcttgcac caacaaagta cacagcttag 900 cagcagtctg accagcgtga aaactagcct gcggtcatct ctcaatgacc ctctgtgctt 960 ggtgcatcca tcaagtgaaa cctgcaacag catcagattg tctctaagcc agctgaatag 1020 caaccctgaa ctgaggcagc ttccacccgt ggatgcagaa cttgacaacg ttaataacgt 1080 tcttaggaca gatttggatg gcctggtcca acagggctat caatccctta atgatatacc 1140 tgacagagta caacgccaaa ccacgactgt cgtagcaggt atcaaaaggg tcttgaattc 1200 cattggttca gatatcgaca atgtaactca gcgtcttcct attcaggata tactctcagc 1260 attctctgtt tatgttaata acactgaaag ttacatccac agaaatttac ctacattgga 1320 agagtatgat tcatactggt ggctgggtgg cctggtcatc tgctctctgc tgaccctcat 1380 cgtgattttt tactacctgg gcttactgtg tggcgtgtgc ggctatgaca ggcatgccac 1440 cccgaccacc cgaggctgtg tctccaacac cggaggcgtc ttcctcatgg ttggagttgg 1500 attaagtttc ctcttttgct ggatattgat gatcattgtg gttcttacct ttgtctttgg 1560 tgcaaatgtg gaaaaactga tctgtgaacc ttacacgagc aaggaattat tccgggtttt 1620 ggatacaccc tacttactaa atgaagactg ggaatactat ctctctggga agctatttaa 1680 taaatcaaaa atgaagctca cttttgaaca agtttacagt gactgcaaaa aaaatagagg 1740 cacttacggc actcttcacc tgcagaacag cttcaatatc agtgaacatc tcaacattaa 1800 tgagcatact ggaagcataa gcagtgaatt ggaaagtctg aaggtaaatc ttaatatctt 1860 tctgttgggt gcagcaggaa gaaaaaacct tcaggatttt gctgcttgtg gaatagacag 1920 aatgaattat gacagctact tggctcagac tggtaaatcc cccgcaggag tgaatctttt 1980 atcatttgca tatgatctag aagcaaaagc aaacagtttg cccccaggaa atttgaggaa 2040 ctccctgaaa agagatgcac aaactattaa aacaattcac cagcaacgag tccttcctat 2100 agaacaatca ctgagcactc tataccaaag cgtcaagata cttcaacgca cagggaatgg 2160 attgttggag agagtaacta ggattctagc ttctctggat tttgctcaga acttcatcac 2220 aaacaatact tcctctgtta ttattgagga aactaagaag tatgggagaa caataatagg 2280 atattttgaa cattatctgc agtggatcga gttctctatc agtgagaaag tggcatcgtg 2340 caaacctgtg gccaccgctc tagatactgc tgttgatgtc tttctgtgta gctacattat 2400 cgaccccttg aatttgtttt ggtttggcat aggaaaagct actgtatttt tacttccggc 2460 tctaattttt gcggtaaaac tggctaagta ctatcgtcga atggattcgg aggacgtgta 2520 cgatgatgtt gaaactatac ccatgaaaaa tatggaaaat ggtaataatg gttatcataa 2580 agatcatgta tatggtattc acaatcctgt tatgacaagc ccatcacaac attgatagct 2640 gatgttgaaa ctgcttgagc atcaggatac tcaaagtgga aaggatcaca gatttttggt 2700 agtttctggg tctacaagga ctttccaaat ccaggagcaa cgccagtggc aacgtagtga 2760 ctcaggcggg caccaaggca acggcaccat tggtctctgg gtagtgcttt aagaatgaac 2820 acaatcacgt tatagtccat ggtccatcac tattcaagga tgactccctc ccttcctgtc 2880 tatttttgtt ttttactttt ttacactgag tttctattta gacactacaa catatggggt 2940 gtttgttccc attggatgca tttctatcaa aactctatca aatgtgatgg ctagattcta 3000 acatattgcc atgtgtggag tgtgctgaac acacaccagt ttacaggaaa gatgcatttt 3060 gtgtacagta aacggtgtat ataccttttg ttaccacaga gttttttaaa caaatgagta 3120 ttataggact ttcttctaaa tgagctaaat aagtcaccat tgacttcttg gtgctgttga 3180 aaataatcca ttttcactaa aagtgtgtga aacctacagc atattcttca cgcagagatt 3240 ttcatctatt atactttatc aaagattggc catgttccac ttggaaatgg catgcaaaag 3300 ccatcataga gaaacctgcg taactccatc tgacaaattc aaaagagaga gagagatctt 3360 gagagagaaa tgctgttcgt tcaaaagtgg agttgtttta acagatgcca attacggtgt 3420 acagtttaac agagttttct gttgcattag gataaacatt aattggagtg cagctaacat 3480 gagtatcatc agactagtat caagtgttct aaaatgaaat atgagaagat cctgtcacaa 3540 ttcttagatc tggtgtccag catggatgaa acctttgagt ttggtcccta aatttgcatg 3600 aaagcacaag gtaaatattc atttgcttca ggagtttcat gttggatctg tcattatcaa 3660 aagtgatcag caatgaagaa ctggtcggac aaaatttaac gttgatgtaa tggaattcca 3720 gatgtaggca ttccccccag gtcttttcat gtgcagattg cagttctgat tcatttgaat 3780 aaaaaggaac ttgg 3794 <210> 104 <211> 765 <212> DNA <213> Homo sapiens <400> 104 atgccagcca agaccccaat ttacctgaaa gcagccaata acaagaaagg aaagaaattt 60 aaactgaggg acattctgtc tcctgatatg atcagtcccc cgcttggaga ctttcgccac 120 accatccaca ttggcaaaga gggccagcac gatgtctttg gagatatttc ctttcttcaa 180 gggaactacg agcttttacc tggaaaccag gagaaagcac acctgggcca gttccctggg 240 cataatgagt tcttccgggc caacagcacc tcggactctg tgttcacaga aacgccctcc 300 ccggtgctca aaaatgccat ctccctcccg accattggag gatcccaagc tctcatgttg 360 cccttattgt caccagtgac atttaattcc aaacaggagt ccttcgggcc agcaaagctg 420 cccaggctta gctgcgagcc cgtcatggag gaaaaagctc aggagaaaag cagtctgttg 480 gagaatggga cagtccacca gggagacacc tcgtggggct ccagcggttc tgcatctcag 540 tccagccaag gcagagacag ccactcctcc agcctgtccg aacagtaccc cgactggcca 600 gccgaggaca tgtttgacca tcccacccca tgcgagctca tcaagggaaa gactaagtca 660 gaggagtccc tctctgacct tacaggttcc ctcctcttcc tgcagcttga tcttgggccc 720 tcacttttgg atgaagtgct gaatgtaatg gataaaaata agtaa 765 <210> 105 <211> 601 <212> DNA <213> Homo sapiens <400> 105 ctgtctgctt cctataccag gttgttcctg attctgaaca ttgctatttt ctttgtcatg 60 ttggcaatgc aactgactta tttccagagg gcccagagcc tacatggcca aagatgtctt 120 tatgcagttc ttctcataga tagctgtatt ttattatggt tgtactcttc ttgttcccaa 180 tcacagtgtt agcactgaag ctataaatta cctggtcatt ttgtgatcac aagagtctat 240 gcaaaaaaaa aatttcttta ccccagatta tcagattttt ttccctcaga ttcattttaa 300 caaattaagg gaagatattt tgacacaaga aagcaggaac gtggagaaat tggagcagga 360 aaagaaatta tcaaagcaat agaaatagct tggtggtcct atggtgtttt tggaagtatt 420 tggcattgct aattgagcag tccatatagt actactttta gaaganacca aaagtctgtt 480 ttttaaagta atgttttttc ctatgagaaa aagggttaga tagaattggg gttttattaa 540 tattaattta atgcnaatag ccatttccat anacgatatt gtggaaaaga ctgnagatnc 600 c 601 <210> 106 <211> 5722 <212> DNA <213> Homo sapiens <400> 106 ggacgcacag gcattccccg cgcccctcca gccctcgccg ccctcgccac cgctcccggc 60 cgccgcgctc cggtacacac aggatccctg ctgggcacca acagctccac catggggctg 120 gcctggggac taggcgtcct gttcctgatg catgtgtgtg gcaccaaccg cattccagag 180 tctggcggag acaacagcgt gtttgacatc tttgaactca ccggggccgc ccgcaagggg 240 tctgggcgcc gactggtgaa gggccccgac ccttccagcc cagctttccg catcgaggat 300 gccaacctga tcccccctgt gcctgatgac aagttccaag acctggtgga tgctgtgcgg 360 gcagaaaagg gtttcctcct tctggcatcc ctgaggcaga tgaagaagac ccggggcacg 420 ctgctggccc tggagcggaa agaccactct ggccaggtct tcagcgtggt gtccaatggc 480 aaggcgggca ccctggacct cagcctgacc gtccaaggaa agcagcacgt ggtgtctgtg 540 gaagaagctc tcctggcaac cggccagtgg aagagcatca ccctgtttgt gcaggaagac 600 agggcccagc tgtacatcga ctgtgaaaag atggagaatg ctgagttgga cgtccccatc 660 caaagcgtct tcaccagaga cctggccagc atcgccagac tccgcatcgc aaaggggggc 720 gtcaatgaca atttccaggg ggtgctgcag aatgtgaggt ttgtctttgg aaccacacca 780 gaagacatcc tcaggaacaa aggctgctcc agctctacca gtgtcctcct cacccttgac 840 aacaacgtgg tgaatggttc cagccctgcc atccgcacta actacattgg ccacaagaca 900 aaggacttgc aagccatctg cggcatctcc tgtgatgagc tgtccagcat ggtcctggaa 960 ctcaggggcc tgcgcaccat tgtgaccacg ctgcaggaca gcatccgcaa agtgactgaa 1020 gagaacaaag agttggccaa tgagctgagg cggcctcccc tatgctatca caacggagtt 1080 cagtacagaa ataacgagga atggactgtt gatagctgca ctgagtgtca ctgtcagaac 1140 tcagttacca tctgcaaaaa ggtgtcctgc cccatcatgc cctgctccaa tgccacagtt 1200 cctgatggag aatgctgtcc tcgctgttgg cccagcgact ctgcggacga tggctggtct 1260 ccatggtccg agtggacctc ctgttctacg agctgtggca atggaattca gcagcgcggc 1320 cgctcctgcg atagcctcaa caaccgatgt gagggctcct cggtccagac acggacctgc 1380 cacattcagg agtgtgacaa aagatttaaa caggatggtg gctggagcca ctggtccccg 1440 tggtcatctt gttctgtgac atgtggtgat ggtgtgatca caaggatccg gctctgcaac 1500 tctcccagcc cccagatgaa tgggaaaccc tgtgaaggcg aagcgcggga gaccaaagcc 1560 tgcaagaaag acgcctgccc catcaatgga ggctggggtc cttggtcacc atgggacatc 1620 tgttctgtca cctgtggagg aggggtacag aaacgtagtc gtctctgcaa caaccccgca 1680 ccccagtttg gaggcaagga ctgcgttggt gatgtaacag aaaaccagat ctgcaacaag 1740 caggactgtc caattgatgg atgcctgtcc aatccctgct ttgccggcgt gaagtgtact 1800 agctaccctg atggcagctg gaaatgtggt gcttgtcccc ctggttacag tggaaatggc 1860 atccagtgca cagatgttga tgagtgcaaa gaagtgcctg atgcctgctt caaccacaat 1920 ggagagcacc ggtgtgagaa cacggacccc ggctacaact gcctgccctg ccccccacgc 1980 ttcaccggct cacagccctt cggccagggt gtcgaacatg ccacggccaa caaacaggtg 2040 tgcaagcccc gtaacccctg cacggatggg acccacgact gcaacaagaa cgccaagtgc 2100 aactacctgg gccactatag cgaccccatg taccgctgcg agtgcaagcc tggctacgct 2160 ggcaatggca tcatctgcgg ggaggacaca gacctggatg gctggcccaa tgagaacctg 2220 gtgtgcgtgg ccaatgcgac ttaccactgc aaaaaggata attgccccaa ccttcccaac 2280 tcagggcagg aagactatga caaggatgga attggtgatg cctgtgatga tgacgatgac 2340 aatgataaaa ttccagatga cagggacaac tgtccattcc attacaaccc agctcagtat 2400 gactatgaca gagatgatgt gggagaccgc tgtgacaact gtccctacaa ccacaaccca 2460 gatcaggcag acacagacaa caatggggaa ggagacgcct gtgctgcaga cattgatgga 2520 gacggtatcc tcaatgaacg ggacaactgc cagtacgtct acaatgtgga ccagagagac 2580 actgatatgg atggggttgg agatcagtgt gacaattgcc ccttggaaca caatccggat 2640 cagctggact ctgactcaga ccgcattgga gatacctgtg acaacaatca ggatattgat 2700 gaagatggcc accagaacaa tctggacaac tgtccctatg tgcccaatgc caaccaggct 2760 gaccatgaca aagatggcaa gggagatgcc tgtgaccacg atgatgacaa cgatggcatt 2820 cctgatgaca aggacaactg cagactcgtg cccaatcccg accagaagga ctctgacggc 2880 gatggtcgag gtgatgcctg caaagatgat tttgaccatg acagtgtgcc agacatcgat 2940 gacatctgtc ctgagaatgt tgacatcagt gagaccgatt tccgccgatt ccagatgatt 3000 cctctggacc ccaaagggac atcccaaaat gaccctaact gggttgtacg ccatcagggt 3060 aaagaactcg tccagactgt caactgtgat cctggactcg ctgtaggtta tgatgagttt 3120 aatgctgtgg acttcagtgg caccttcttc atcaacaccg aaagggacga tgactatgct 3180 ggatttgtct ttggctacca gtccagcagc cgcttttatg ttgtgatgtg gaagcaagtc 3240 acccagtcct actgggacac caaccccacg agggctcagg gatactcggg cctttctgtg 3300 aaagttgtaa actccaccac agggcctggc gagcacctgc ggaacgccct gtggcacaca 3360 ggaaacaccc ctggccaggt gcgcaccctg tggcatgacc ctcgtcacat aggctggaaa 3420 gatttcaccg cctacagatg gcgtctcagc cacaggccaa agacgggttt cattagagtg 3480 gtgatgtatg aagggaagaa aatcatggct gactcaggac ccatctatga taaaacctat 3540 gctggtggta gactagggtt gtttgtcttc tctcaagaaa tggtgttctt ctctgacctg 3600 aaatacgaat gtagagatcc ctaatcatca aattgttgat tgaaagactg atcataaacc 3660 aatgctggta ttgcaccttc tggaactatg ggcttgagaa aacccccagg atcacttctc 3720 cttggcttcc ttcttttctg tgcttgcatc agtgtggact cctagaacgt gcgacctgcc 3780 tcaagaaaat gcagttttca aaaacagact catcagcatt cagcctccaa tgaataagac 3840 atcttccaag catataaaca attgctttgg tttccttttg aaaaagcatc tacttgcttc 3900 agttgggaag gtgcccattc cactctgcct ttgtcacaga gcagggtgct attgtgaggc 3960 catctctgag cagtggactc aaaagcattt tcaggcatgt cagagaaggg aggactcact 4020 agaattagca aacaaaacca ccctgacatc ctccttcagg aacacgggga gcagaggcca 4080 aagcactaag gggagggcgc atacccgaga cgattgtatg aagaaaatat ggaggaactg 4140 ttacatgttc ggtactaagt cattttcagg ggattgaaag actattgctg gatttcatga 4200 tgctgactgg cgttagctga ttaacccatg taaataggca cttaaataga agcaggaaag 4260 ggagacaaag actggcttct ggacttcctc cctgatcccc acccttactc atcaccttgc 4320 agtggccaga attagggaat cagaatcaaa ccagtgtaag gcagtgctgg ctgccattgc 4380 ctggtcacat tgaaattggt ggcttcattc tagatgtagc ttgtgcagat gtagcaggaa 4440 aataggaaaa cctaccatct cagtgagcac cagctgcctc ccaaaggagg ggcagccgtg 4500 cttatatttt tatggttaca atggcacaaa attattatca acctaactaa aacattcctt 4560 ttctcttttt tccgtaatta ctaggtagtt ttctaattct ctcttttgga agtatgattt 4620 ttttaaagtc tttacgatgt aaaatattta ttttttactt attctggaag atctggctga 4680 aggattattc atggaacagg aagaagcgta aagactatcc atgtcatctt tgttgagagt 4740 cttcgtgact gtaagattgt aaatacagat tatttattaa ctctgttctg cctggaaatt 4800 taggcttcat acggaaagtg tttgagagca agtagttgac atttatcagc aaatctcttg 4860 caagaacagc acaaggaaaa tcagtctaat aagctgctct gccccttgtg ctcagagtgg 4920 atgttatggg attccttttt tctctgtttt atcttttcaa gtggaattag ttggttatcc 4980 atttgcaaat gttttaaatt gcaaagaaag ccatgaggtc ttcaatactg ttttacccca 5040 tcccttgtgc atatttccag ggagaaggaa agcatataca cttttttctt tcatttttcc 5100 aaaagagaaa aaaatgacaa aaggtgaaac ttacatacaa atattacctc atttgttgtg 5160 tgactgagta aagaattttt ggatcaagcg gaaagagttt aagtgtctaa caaacttaaa 5220 gctactgtag tacctaaaaa gtcagtgttg tacatagcat aaaaactctg cagagaagta 5280 ttcccaataa ggaaatagca ttgaaatgtt aaatacaatt tctgaaagtt atgttttttt 5340 tctatcatct ggtataccat tgctttattt ttataaatta ttttctcatt gccattggaa 5400 tagaatattc agattgtgta gatatgctat ttaaataatt tatcaggaaa tactgcctgt 5460 agagttagta tttctatttt tatataatgt ttgcacactg aattgaagaa ttgttggttt 5520 tttctttttt ttgttttttt tttttttttt tttttttttg cttttgacct cccattttta 5580 ctatttgcca ataccttttt ctaggaatgt gctttttttt gtacacattt ttatccattt 5640 tacattctaa agcagtgtaa gttgtatatt actgtttctt atgtacaagg aacaacaata 5700 aatcatatgg aaatttatat tt 5722 <210> 107 <211> 454 <212> DNA <213> Homo sapiens <400> 107 ctcagctcct ggggctcctg ctgctctggc tctcaggtgc cacatgtgac atccagatga 60 cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc acttgccagg 120 cgactcagga cattggcaac tatttaaatt ggtatcagca caaaccaggg aaagccccta 180 acctcctgat ctacgatgca tccaatttgg aaacaggggt cccatcaagg ttcagtggac 240 gtggatctgg gacacatttt actttcacca tcagcagcct gcagcctgaa gatattgcaa 300 catattactg tcaacagtat ggtaatctcc cattcacttt cggccctggg accaaagtgc 360 atatcaaacg aactgtggct gcaccatctg tcttcatctt ccgccatctg atgagcagtt 420 gaaatctgga ctgcctctgt tgtgtgcctg ctga 454 <210> 108 <211> 424 <212> DNA <213> Homo sapiens <400> 108 ttttttttgc acggtgtttc tttaatggaa agacagccac cgacctcaaa agcagcccct 60 ccttgcgctg gaccagaagg ataaggggag acctaaccac cagtgggcca gtgggggtga 120 ggggcttcta ggaaaaccgg tgtctgggac tctggcggtt gatggtgtca tctgcgcggg 180 atgctgggcc tccaacctcc caacctcctc cgggacagta caggtttggg ggcaaggcct 240 gagcagggca ggctggggag accgctgtcc ctggggtttt gtgggcaggg gctgggtgca 300 ggccggacag acagaaagca gtcccagctc aaggcagaag gccagagggt gtggagtgaa 360 agggacaggc gaagccaggt tcggagagat ggagggaaca ggccaccaag ctcagaagcg 420 agaa 424 <210> 109 <211> 2000 <212> DNA <213> Homo sapiens <400> 109 tttgggctgt gtgtgcgacg cgggtcggag gggcagtcgg gggaaccgcg aagaagccga 60 ggagcccgga gccccgcgtg acgctcctct ctcagtccaa aagcggcttt tggttcggcg 120 cagagagacc cgggggtcta gcttttcctc gaaaagcgcc gccctgccct tggccccgag 180 aacagacaaa gagcaccgca gggccgatca cgctgggggc gctgaggccg gccatggtca 240 tggaagtggg caccctggac gctggaggcc tgcgggcgct gctgggggag cgagcggcgc 300 aatgcctgct gctggactgc cgctccttct tcgctttcaa cgccggccac atcgccggct 360 ctgtcaacgt gcgcttcagc accatcgtgc ggcgccgggc caagggcgcc atgggcctgg 420 agcacatcgt gcccaacgcc gagctccgcg gccgcctgct ggccggcgcc taccacgccg 480 tggtgttgct ggacgagcgc agcgccgccc tggacggcgc caagcgcgac ggcaccctgg 540 ccctggcggc cggcgcgctc tgccgcgagg cgcgcgccgc gcaagtcttc ttcctcaaag 600 gaggatacga agcgttttcg gcttcctgcc cggagctgtg cagcaaacag tcgaccccca 660 tggggctcag ccttcccctg agtactagcg tccctgacag cgcggaatct gggtgcagtt 720 cctgcagtac cccactctac gatcagggtg gcccggtgga aatcctgccc tttctgtacc 780 tgggcagtgc gtatcacgct tcccgcaagg acatgctgga tgccttgggc ataactgcct 840 tgatcaacgt ctcagccaat tgtcccaacc attttgaggg tcactaccag tacaagagca 900 tccctgtgga ggacaaccac aaggcagaca tcagctcctg gttcaacgag gccattgact 960 tcatagactc catcaagaat gctggaggaa gggtgtttgt ccactgccag gcaggcattt 1020 cccggtcagc caccatctgc cttgcttacc ttatgaggac taatcgagtc aagctggacg 1080 aggcctttga gtttgtgaag cagaggcgaa gcatcatctc tcccaacttc agcttcatgg 1140 gccagctgct gcagtttgag tcccaggtgc tggctccgca ctgttcggca gaggctggga 1200 gccccgccat ggctgtgctc gaccgaggca cctccaccac caccgtgttc aacttccccg 1260 tctccatccc tgtccactcc acgaacagtg cgctgagcta ccttcagagc cccattacga 1320 cctctcccag ctgctgaaag gccacgggag gtgaggctct tcacatccca ttgggactcc 1380 atgctccttg agaggagaaa tgcaataact ctgggagggg ctcgagaggg ctggtcctta 1440 tttatttaac ttcacccgag ttcctctggg tttctaagca gttatggtga tgacttagcg 1500 tcaagacatt tgctgaactc agcacattcg ggaccaatat atagtgggta catcaagtcc 1560 atctgacaaa atggggcaga agagaaagga ctcagtgtgt gatccggttt ctttttgctc 1620 gcccctgttt tttgtagaat ctcttcatgc ttgacatacc taccagtatt attcccgacg 1680 acacatatac atatgagaat ataccttatt tatttttgtg taggtgtctg ccttcacaaa 1740 tgtcattgtc tactcctaga agaaccaaat acctcaattt ttgtttttga gtactgtact 1800 atcctgtaaa tatatcttaa gcaggtttgt tttcagcact gatggaaaat accagtgttg 1860 ggtttttttt tagttgccaa cagttgtatg tttgctgatt atttatgacc tgaaataata 1920 tatttcttct tctaagaaga cattttgtta cataaggatg acttttttat acaatggaat 1980 aaattatggc atttctattg 2000 <210> 110 <211> 719 <212> DNA <213> Homo sapiens <400> 110 tcctttttcc aatcttcatt ctcggggttg gcccgccccg atagtcactc catgtcctcg 60 tttactggtt catcttcgta atctctgtca tggtcaaaat ctggactgtg gttggctgtt 120 gtcactaagg acaggggccc ttcagcttcc tctggatcga ggggctcttc tttgacgtgt 180 acaggatgca cggcttgcat aggagatctg cctggactgc tgtcactctc gttgctgttg 240 gtatgctcca ttgccccgtt cagctcttcc cgtattgcgc tggctaagtt gcccagagtg 300 ggatttccca tggaagcggt agtgtataga ggtatactat tctcagccat tgaagcctgt 360 aaagctgcat tgagaggtgt gcagtaggcg tggctgctct gcatgttttt aataagggaa 420 gggttaccac tgatcttttg tggccttcgt ttttggaatt ctacttcatc cactgtccat 480 actgcccctt taacgttttc tactcgcaca aaacacttgt gaagactaag attatgacgc 540 actgcattct tccacgtggc cgcgttgcgt cngaagtaag caaacattcg tgtgaaccag 600 ttatagatct catttagtgt tagctgcttt tctggaaatt cgagaatggc ctgccttatt 660 taagaagcat atgtaaaatg tggtctaacc tcctgcgtct tattaaaatc cttggtctg 719 <210> 111 <211> 466 <212> DNA <213> Homo sapiens <400> 111 tactgacttg cttccggagt ttattgtgca ggatgaagcc cgagtggnaa gggttgcttt 60 ggcggggagc ggggcagggg ctcggggaag gaacagagca gagacatcca gagcgtgggg 120 gtcacctggc tggccgggat cccagcttca gccctgggga gtcctgaggg gtgtgaccga 180 aaggctagga tggaggactg cagtctaccc cagcccacct ccactccagt cgatggagca 240 ggtgcgggct acggggactt ttctctgccc ccagccccac tgagccccgc tgagagaagc 300 aagatccatc cctggggctt tggattcccc gttggcccca agggtctana agacttccaa 360 ccttttccaa gcccccaagg gttcaanaaa attccaggtt ccaggcttaa ggcttncctt 420 ccttgggggt tngttgggtt aaaatccgnc ctgaagcttg tttttc 466 <210> 112 <211> 513 <212> DNA <213> Homo sapiens <400> 112 aattcggcat gaggggctaa atgtatcatc ttgctactgg aaagaaattg ttcacaaaac 60 caatgagatc atgctggttc tctcatcttt caatagttgc ttagatccag tcatgtattt 120 cctgatgtcc agtaacattc gcaaaataat gtgccaactt ctttttagac gatttcaagg 180 tgaaccaagt aggagtgaaa gcacttcaga atttaaacca ggatactccc tgcatgatac 240 atctgtgggc agtgaaaata cagtctagtt ctaaaagtac ttgaggtaaa catactaaaa 300 tgaattatat aatgcagcct cttaattctt tgaagagcta aaaaattagg aaacaaagtt 360 ctagcattta caaaactcag atcttcaagg cttctgcttg gtattttgtg gatatttcct 420 tttgcttaac tgttaaccct tttcaagggt ncttttcttt taaattctgg tatggtaaaa 480 tccttttcca aaattacctt tttttnaggc taa 513 <210> 113 <211> 617 <212> DNA <213> Homo sapiens <400> 113 ngcggctctt tggaattgta atttgagaag gattgtgaag aaatcagtgg gcttaatagg 60 aaatagtgct gtgattgatt agcaatgtct gccatggcca caaaaattgg tattgataaa 120 ataaatgcat cccaggccct tatatctctg ttctaagtaa agtgagtgaa tgaagctggc 180 ttgatgtatt tttgaaggat ctttggagac catagcccaa gccactaaat gtatatttat 240 tttatattct gccttgttcc agaaaagatc tgagaatttg ggtggcttgg gacaggaatt 300 ttaggatttg tggaaagcta gagagagaga taattttgaa taggctgatg caggaggtcc 360 aagacaatga tctctgtttt tatccctggg tgatgaagcc cagtgtttag caagtgatta 420 tagggcttat tgattaaaca gatccagaaa gacctggata aatggggtga gtcctaggca 480 tggtggaaat ttcnggcaga gcatttcctg tggttgcaga tccgatggaa ttccccctgg 540 gttaccagnc tgaggttcca atnccgaaaa cccaaggnga agtatatttg tatcccncac 600 atgccctatg ggggggt 617 <210> 114 <211> 444 <212> DNA <213> Homo sapiens <400> 114 actcaaaaca gagaataagt tcctatgctg ttagtactgt atcttgtcca cacctcaaac 60 aacagtgaga tctctgagca catggtctgt acctcaacca cttttctatc accagggtct 120 agaatagttg ggcatttaaa taaaatttgc taaatgaatg aaaaatccaa aataaatcat 180 gaagccattt ataaatcaca ccaatcttgc ttgggnttaa acaatagaaa gtaacacttt 240 tgaaagagaa ggcaaacagg tgttagaggg gcaaggantg tgaggctcga gggaaaagac 300 agctacgaac tgtgttttta acaactcatt atttgggcta ctatatttcc caatctattc 360 taacactaac agggatctgt ctnattaatt gtggacaccn tctggcaaaa ccntggttac 420 cncttttttc tttcccactc tttt 444 <210> 115 <211> 628 <212> DNA <213> Homo sapiens <400> 115 tttttttttt tttttttttt tttttttttt ttttttaaaa aaaagacatt tattcagggg 60 cccgaccaga ctggtacatt tagcaatcaa cagcaggggg ggcaaaaaaa aatctacatt 120 aaaacccttt gggggaaggc tttacccttt ccacagaaca gaaactaaaa taaccgggta 180 tacaattagg cacaaatacc ggcctcgggt tttttgccca tacccatgag tatttgtcta 240 aaacatgtct tctttgtagc agctaggccc tgccaccact gggcttgggt gagttcacaa 300 atctggggga acctggagct tccctggcac ttctctggct ctcctctcct gctaagcttt 360 gtttcctaat taaaatcttc tgccactgcc atagctactg ctgctgctgg aaccgccata 420 gccaccttgg tttcggggtt tgcaaagtat tggcctccac cgccataggg gccagagctt 480 ctgcctccaa aatttcctcc cttcatgggc caaaatttga agacgggttg ttgaattcca 540 aaaatcattg tagcttcccc accttcaaaa ttgcttcatc tttacaaatt catatagcat 600 tcccactggc ccatattccc accaccac 628 <210> 116 <211> 683 <212> DNA <213> Homo sapiens <400> 116 tttttttttt tttttgagct tccaaaataa cttttattac tatataaaag aagtcaagaa 60 aaaatagatg catatttttc ctacaaaatt ataaaatatt caggatagtt aatatttttt 120 ccataaatgc gctaagataa aaagatagaa atctttttca cttaaggttt tcgagtacct 180 tgtaggaatt aaagaataat aatgttcttt cttctacatt ttcctaaaga catagcagtt 240 acagtttcct gctggagtta tctaaaaaag gacataccca gataaatttt ctatccatat 300 tgaaataaaa ttagcataaa gctttacttc cggtctttgt gcttttagat tgggcaactg 360 tggtcnatcc agtgctgcac tgggaatttc caactcagcc gggggaaaga atctaattaa 420 aaatgacacc ccaccctgta atttggcctt tagaaaacca gaaactgctt ggcggatatc 480 cccttaaaaa gtgcnatttg cnctctttgg ccaattcttt ggtaaagtcc tgaggaaggt 540 ggttcctaaa cagcacaggn ttacatggna accccgccag gttaanggaa agaaaatgcc 600 tttgaanggc caggtcccat ttggcnccaa gcagcnccgg gaanccgtac acntttggag 660 gccngaattc caaaggttat cca 683 <210> 117 <211> 470 <212> DNA <213> Homo sapiens <400> 117 ttttttttca caggtttatt ctgagtttta atttattata caaaagtaaa ggttttaatt 60 taatattaat agtagaaaaa cactttctta cgtgtgccat atggaaagat aaaggatcta 120 ttctaaaatt agctgtgttg gttgataagc tggtgtggat tctgccacat ccagcaagga 180 agataccatt aaattacaca gtttagctct ctctatctat gcattaggaa tttgacttcc 240 atttgatgtt aaagcatata cttggcttta aggacacact aaaactattc aaagtttaat 300 tacattcaga caaagatcat ctaaccactg ttgctacata gggaatattt atttaattat 360 cccttgctat ctctattaat cagtttcctc aatttatcct taaaattttc ctcaaatgct 420 tagttatttt attatttgct ttttaaaata ttcagtgtca aaacaaaagt 470 <210> 118 <211> 575 <212> DNA <213> Homo sapiens <400> 118 ccgccgttaa agttttattt tttggaggac gcgcggcgag gggggccggg aaggggcggg 60 ggcagccgag cgaggcgggg cgctcactcc cgcttccgta ggtggatgta gatgatgccg 120 ctgaccaggg cgagggggaa ggccacccag gccagggcga agcagtatcc gaagctgccc 180 cctcgcgggt gcttctccag gatctcctcg gcgtgaatgg catagatcaa ggcgccagta 240 aacaccgcca cgctggtgca aagctggcag aggccggtgg catagaagag acctcctcgt 300 cgcatggtgt agagctggaa catgaacagg atgaaggaga gacagcagag aatgagggag 360 agcaccatga ggacctgcac cgccttcagc cagccattct cgctgacatt actgcaggcc 420 catgttttgg tgtcgttgtt ccacgtgcag tcgtaccaga gattcaggga ctctttccca 480 gggagagtcc accaggactt gtccaaagtg gccacgaaaa gcagtataag aatgaggatg 540 tgaagggctg agaccaccag caagaggagt gacat 575 <210> 119 <211> 558 <212> DNA <213> Homo sapiens <400> 119 tcaacatgga aaaactgttc aggcacaaag attaaacaag cccgcgttgc atcccttgga 60 ttgtactgaa tcactgggtc ccccagcctc cctacctacc cctgcacccc agatntgcct 120 tccccatatt catggcctcc tcctccaaag cagcccaaag cagcaatgat atttactatt 180 ttatatcaat ctcttgctat atatatatat atctatatat ctatatattt gnctatccna 240 tatatacata ggnttttaat gcnttgaatg agtgaaggag tgaataggga aagagcacat 300 gagtgaggtg taaatgtcac cnaatgcatt aagggacata tttgtaggag ctggacatgg 360 gaaagggnta ttaaccaacg tggccttgca ggctggagaa gtttttcact gtgctggata 420 aggcagtagc aagcagggtt gtcagcagta ccacagctaa aggcagccag ggggcgaaga 480 gtcaggtggc atgagaaaag ggaggcagat attnagatcc ncctgggnga gacccgttta 540 ccncctccnt cccctaat 558 <210> 120 <211> 631 <212> DNA <213> Homo sapiens <400> 120 ttttttggat tgcaaaaatt tattaaaatt ggagacactg ttttaatctt cttgtgccat 60 gagactccat caggcagtct acaaagacca ctgggaggct gaggatcact tgagcccaga 120 agtttgaggc tgtagtaagc ttcaaaggcc actgcactct agcttgggtg aggcaagacc 180 ctttcaagca gtaagctgca tgcttgcttg ttgtggtcat taaaaaccct agtttaggat 240 aacaggtctg cctgcatttc ttcaatcatg aattctgagt cctttgcttc tttaaaactt 300 gctccacaca gtgtagtcaa gccgactctc cataccttta aaaggtatga caggaactgt 360 cttcatgtcc ttacccaagc aagtcatcca tggataaaaa cgttaccagg agcagaacca 420 ttaagctggt ccaggcaagt tggactccac catttcaact tccagctntc tgtctaatgc 480 ctgtgtgcca atggcttgag ttaggcttgc tctntaggac ttcagtagct attctcatcc 540 ttccttgggg acacaactgt ccataaggtg ctatncagag ccacactgca tctgcaccca 600 gcaccatacc tcacangagt cgacctcgtg c 631 <210> 121 <211> 480 <212> DNA <213> Homo sapiens <400> 121 tttgtgaggg aagcagcggt ctctgacgcc ggctttatta taagcatgag gtggcacgag 60 gcaggagttg gcgatgcacc tgggggtcac attgagtctg gagcttcctt cagcccaagc 120 gctggcagtg acggggaaaa gntctaaagc ccagggaaga aggggaggcg ccagagnagg 180 ngccattgct tggcttccca gctggcccca gtgcagtggg tggcaccgcg aggctgctgt 240 tacggctcat cttcattgat ttgcctgcgc ttcttattgc ccccacagcg gaatcttctg 300 ctgaggagga tgaggagccc ccacgatgaa ggccagtcca gcgaagatca gggcccccat 360 tggcgaacgg tctcatagtc atagtagaac gggtccantt ccccttgggc ttgccggcaa 420 ccgttccatt cgacaaaccc agtcaatttc cccanggttg aattgggttg cntccaattc 480 <210> 122 <211> 717 <212> DNA <213> Homo sapiens <400> 122 gggagcatgg acctcagtct tctctgggta cttatgcccc tagtcaccat ggcctggggc 60 cagtatggcg attatggata cccataccag cagtatcatg actacagcga tgatgggtgg 120 gtgaatttga atcggcaagg cttcagctac cagtgtcccc aggggcaggt gatagtggcc 180 gtgaggagca tcttcagtaa gaaggaaggt tctgacagac aatggaacta cgcctgcatg 240 cccacgccac agagcctcgg ggaacccacg gagtgctggt gggaggagat caacagggct 300 ggcatggaat ggtaccagac gtgctccaac aatgggctgg tggcaggatt ccagagccgc 360 tacttcgagt cagtgctgga tcgggagtgg cagttttact gttgtcgcta cagcaagagg 420 tgcccatatt cctgctggct aacaacagaa tatccaggtc actatggtga ggaaatggac 480 atgatttcct acaattatga ttactatatc cgaggagcaa caaccacttt ctctgcagtg 540 gaaagggatc gccagtggaa gttcataatg tgccggatga ctgaatacga ctgtgaattt 600 gcaaatgttt agatttgcca cataccaaat ctgggtgaaa ggaaaggggc cctccagctt 660 tccactgcag agaaagtggt tgttgctcct cggtatatgt aatcataatt gtagatc 717 <210> 123 <211> 374 <212> DNA <213> Homo sapiens <400> 123 gaggtgcagc tgttggagtc tgggggaggc ttagtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct cttagtggta gtggtggtac cagatagtac 180 gcagacttcg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatca acaccctgag agccgaagac acggccgtat attactgtgc gaaagaacga 300 tatccggggg catacatatt tcctgactct tggggccatg gaaccctggt caccgtctcc 360 tcagcctcca ccaa 374 <210> 124 <211> 2368 <212> DNA <213> Homo sapiens <400> 124 cgggcgatgc cgcgctgcgg gggggccgca cagccgccgc caccgccacc gccgccgggt 60 ggggtgggag gggcgggaac gcgcgccgcc gcctccaggg tgggcgcctt tcgccgtgga 120 cgccgaccgt ccgggacgag ggtttcatca ccttaaatgg ttttgaacca atgaaggtgt 180 attcccttaa aaagacggac agcccatcgt gtgaactata gagtttgtgg acagatttat 240 attgggttca tagtggcgtc atgcacgcag actcctgcaa gttcccctaa gttcttagag 300 gactgctttg ccttttgatc tgagagttgc aaagttccat aaagaatggc ccttgtggat 360 aagcacaaag tcaagagaca gcgattggac agaatttgtg aaggtatccg cccccagatc 420 atgaacggcc ccctgcaccc ccgccccctg gtggcgctgc tggacggccg cgactgcact 480 gtggagatgc ccatcctgaa ggacctggcc actgtggcct tctgtgacgc gcagtcgacg 540 caggaaatcc acgagaaggt tctaaacgaa gccgtgggcg ccatgatgta ccacaccatc 600 accctcacca gggaggacct ggagaagttc aaggccctga gagtgatcgt gcggataggc 660 agtggctatg acaacgtgga catcaaggct gccggcgagc tcggaattgc cgtgtgcaac 720 atcccgtctg cagccgtgga agagacagcg gactctacca tctgccacat cctcaacctg 780 taccggagga acacgtggct gtaccaggca ctgcgggaag gcacgcgggt tcagagcgtg 840 gagcagatcc gcgaggtggc ctcgggagcg gcccgcatcc gtggggagac gctgggcctc 900 attggctttg gtcgcacggg gcaggcggtt gcagttcgag ccaaggcctt tggattcagc 960 gtcatatttt atgaccccta cttgcaggat gggatcgagc ggtccctggg cgtgcagagg 1020 gtctacaccc tgcaggattt gctgtatcag agcgactgcg tctccttgca ctgcaatctc 1080 aacgaacata accaccacct catcaatgac tttaccataa agcagatgag gcagggagca 1140 ttccttgtga acgcagcccg tggcggcctg gtggacgaga aagccttagc acaagccctc 1200 aaggagggca ggatacgagg ggcagccctc gacgtgcatg agtcagagcc cttcagcttt 1260 gctcagggtc cgttgaaaga tgccccgaat ctcatctgca ctcctcacac tgcctggtac 1320 agtgagcagg cgtcactgga gatgagggag gcagctgcca ccgagatccg ccgagccatc 1380 acaggtcgca tcccagaaag cttaagaaat tgtgtgaaca aggaattctt tgtcacatca 1440 gcgccttggt cagtaataga ccagcaagca attcatcctg agctcaatgg tgccacatac 1500 agatatccgc caggcatcgt gggtgtggct ccaggaggac ttcctgcagc catggaaggg 1560 atcatccctg gaggcatccc agtgactcac aacctcccga cagtggcaca tccttcccaa 1620 gcgccctctc ccaaccagcc cacaaaacac ggggacaatc gagagcaccc caacgagcaa 1680 tagcagagaa tgccagaagg taatcactca gatacacttg ggaccaagag acagtgaaaa 1740 atagatgaac taagagaaaa agaatcggat ggtctttgta actgattctg gacatatgca 1800 tcattgatgt tgcagtgttg aaactacaag agctagaaaa ctgaagatgt cgtctgctta 1860 cggaagcgct gaaagactag gatgtgattt attaacgacc aacttctgtt attgtgtgtt 1920 aagtttttca tctgtgcatc aaatcacaaa aagaataaat agagcttttt cctttatcag 1980 tcccttgggc acagcaggtc ctgaacaccc tgctctacaa tgttgcatca agagttcaaa 2040 caacaaaata aaaaatatta agaggaaatc cccatcctgt gacttgagtc ccttaagtct 2100 acaggggctg gtgacctctt tttgctaata ggaaaatcac attactacaa aatggggaga 2160 aaactgtttg cctgtggtag acacctgcac gcataggatt gaagacagta caggctgctg 2220 tacagagaag cgcctctcac atctgaactg catactgagc gggcaagtcg gttgtaagtt 2280 cagtaaaacc ctctgatgat gcaaaaaaaa aaaaaaagta ttaagtttca caagctgttt 2340 gtactcaaat atattttctc agtttcag 2368 <210> 125 <211> 1437 <212> DNA <213> Homo sapiens <400> 125 cggcagcagc gctcgcgtcc tccccagcaa cagttactca aagctaatca gatagcgaaa 60 gaagcaggag agcaagtcaa gaaatacggt gaaggagtcc ttcccaaagt tgtctaggtc 120 cttccgcgcc ggtgcctggt cttcgtcgtc aacaccatgg acagctcccg ggaaccgact 180 ctggggcgct tggacgccgc tggcttctgg caggtctggc ggcgctttga tgcggatgaa 240 aaaggttaca tagaagagaa ggaactcgat gctttctttc tccacatgtt gatgaaactg 300 ggtactgatg acacggtcat gaaagcaaat ttgcacaagg tgaaacagca gtttatgact 360 acccaagatg cctctaaaga tggtcgcatt cggatgaaag agcttgctgg tatgttctta 420 tctgaggatg aaaactttct tctgctcttt cgccgggaaa acccactgga cagcagcgtg 480 gagtttatgc agatttggcg caaatatgac gctgacagca gtggctttat atcagctgct 540 gagctccgca acttcctccg agacctcttt cttcaccaca aaaaggccat ttctgaggct 600 aaactggaag aatacactgg caccatgatg aagatttttg acagaaataa agatggtcgg 660 ttggatctaa atgacttagc aaggattctg gctcttcagg aaaacttcct tctccaattt 720 aaaatggatg cttgttctac tgaagaaagg aaaagggact ttgagaaaat ctttgcctac 780 tatgatgtta gtaaaacagg agccctggaa ggcccagaag tggatgggtt tgtcaaagac 840 atgatggagc ttgtccagcc cagcatcagc ggggtggacc ttgataagtt ccgcgagatt 900 ctcctgcgtc actgcgacgt gaacaaggat ggaaaaattc agaagtctga gctggctttg 960 tgtcttgggc tgaaaatcaa cccataatcc cagactgctt tgccttttgc tcttactatg 1020 tttctgtgat cttgctggta gaattgtatc tgtgcattga tgttgggaac acagtgggca 1080 aactcacaaa tggtgtgcta ttcttgggca agaagaggga cgctagggcc ttccttccac 1140 cggcgtgatc tatccctgtc tcactgaaag cccctgtgta gtgtctgtgt tgttttccct 1200 tgaccctggg ctttcctatc ctcccaaaga ctcagctccc ctgttagatg gctctgcctg 1260 tccttcccca gtccaccagg gtggggggga caggggcagc tgagtgcatt cattttgtgc 1320 ttttgttgtg ggctttctgc ttagtctgaa aggtgtgtgg cattcatggc aatcctgtaa 1380 cttcaacata gatttttttt gtgtgtgtgg aaataaatct gcaattggaa acaaccg 1437 <210> 126 <211> 456 <212> DNA <213> Homo sapiens <400> 126 tataacattt aaaactactt atttttattt atatcagagt aacaaatact tatgaagtcc 60 tttgaagttc agcgcacaaa tttctcgtgt ggggcggtgg gtgtggccat gttcttgctc 120 ttccttcttt acacatttga gttgtgcctt ctgttcttaa agagattttc ctttgttcaa 180 aggatttttt cctaccattt cacaaatccg aaaataattg aggaaacagg ttacatcatt 240 ccaattttgc cttgggtttg aagagtctct catggtggca cagtcctcca gggtagctat 300 gttgttgggc tcccctacat cccagaagct cagagacttt gtcaaaggtg tgccgtccac 360 ccattgccac tgaccctcga caacctggtc tgacagtcca ataaaaaact ctctcatttt 420 aggtttcttg taggaaagga attcctgctc ctcctg 456 <210> 127 <211> 315 <212> DNA <213> Homo sapiens <400> 127 tttttttttt tttttttgcc tgaaaaactc ctgaaggacc cacgtggccc aggaagttta 60 ctgtcccccc gacccacaaa aattctttta taaaatcttc cagtgcgatc ttcgggaaac 120 cccctgccct ccccggctcc cccctccctg gccctcctgt gtccccacaa ccctgggctg 180 cccccagctc cagcccagcg cccggcggcg tccagtctca tctctggccg tccatggccg 240 ccatggcttt ctgctgggcg cccccctgct gtgctcctgg gggccacgtg ggctgtgggc 300 ggtggaggtg gtgga 315 <210> 128 <211> 509 <212> DNA <213> Homo sapiens <400> 128 ggaacattaa aataaacctg cagtttaaca gaattttgta ttaaatnggg gagtgtcaat 60 ttgcatcatt tgcatattga tttcaagtct cctaatttgg aatgggtaaa gtacaaatgt 120 taatgcaaca tagtacagtt gtatttgtcc ttcatattca ggatgtgata tttacaaaat 180 gcagaacagt ttaaacttgt taagtcacat tccagattag gagaaaatgg gcaataatca 240 tctctgtttt gcccccattc tactacccac cactgcccac cccaccccca catcacacac 300 tcttcgatgc tttcccacag cccctgctcc gctcctctcc gtaaggaaac ttcactttca 360 ctgttttttc actttttcac ttctgggctt tttttgtggg gcccaagggc aattataggg 420 gttnaattat ctggtggttn ccaggnttca gccagaacgg ttatggtcng ttccatnttt 480 cttcctttct ttccanggaa aaaanggtt 509 <210> 129 <211> 449 <212> DNA <213> Homo sapiens <400> 129 ttctttaatg gaaagacagc caccgacctc agaagcagcc cctccttgcg ctggaccaga 60 aggataaggg gagacctagc caccagtggg ccagtggggg tgaggggctt ctaggaaaac 120 cggtgtctgg gactctggcg gttgatggtg tcatctgcgc gggatgctgg gcctccacct 180 cccaacctcc tccgggacag tacaggtttg ggggcaaggc tgagcagggc aggctgggga 240 gaccgctgtc cctggggttt tgtgggcagg ggctgggtgc aggccggaca gacagaaagc 300 agtcccagct caaggcagaa ggccagaggg tttggagtga aagggacagg cgacagggtt 360 tcggagagnt gggagggaac aggccaccaa gcttcagaag ccagaaaggt tttnagggaa 420 gcacaagnca cacacacaca canacacac 449 <210> 130 <211> 2097 <212> DNA <213> Homo sapiens <400> 130 agcttcttgg atgatgatgg acgtcccacc gggcaggatg aaggcagagc gtgtggcatc 60 tccacctcaa gggtgcagcc tgatcttcct cttctccctt gccagccagc actctgcctt 120 ctgtatccac catggtgttt ggtgagtttt tccatcgccc tggacaagac gaggaacttg 180 tcaacctgaa tgtggggggc tttaagcagt ctgttgacca aagcaccctc ctgcggtttc 240 ctcacaccag actggggaag ctgcttactt gccattctga agaggccatt ctggagctgt 300 gtgatgatta cagtgtggcc gataaggaat actactttga tcggaatccc tccttgttca 360 gatatgtttt gaatttttat tacacgggga agctgcatgt catggaggag ctgtgcgtat 420 tctcattctg ccaggagatc gagtactggg gcatcaacga gctcttcatt gattcttgct 480 gcagcaatcg ctaccaggaa cgcaaggagg aaaaccacga gaaggactgg gaccagaaaa 540 gccatgatgt gagtaccgac tcctcgtttg aagagtcgtc tctgtttgag aaagagctgg 600 agaagtttga cacactgcga tttggtcagc tccggaagaa aatctggatt agaatggaga 660 atccagcgta ctgcctgtcc gctaagctta tcgctatctc ctccttgagc gtggtgctgg 720 cctccatcgt ggccatgtgc gttcacagca tgtcggagtt ccagaatgag gatggagaag 780 tggatgatcc ggtgctggaa ggagtggaga tcgcgtgcat tgcctggttc accggggagc 840 ttgccgtccg gctggctgcc gctccttgtc aaaagaaatt ctggaaaaac cctctgaaca 900 tcattgactt tgtctctatt attcccttct atgccacgtt ggctgtagac accaaggagg 960 aagagagtga ggatattgag aacatgggca aggtggtcca gatcctacgg cttatgagga 1020 ttttccgaat tctaaagctt gcccggcact cggtaggact tcggtcttta ggtgccacac 1080 tgagacacag ctaccatgaa gttgggcttc tgcttctctt cctctctgtg ggcatttcca 1140 ttttctctgt gcttatctac tccgtggaga aagatgacca cacatccagc ctcaccagca 1200 tccccatctg ctggtggtgg gccaccatca gcatgacaac tgtgggctat ggagacaccc 1260 acccggtcac cttggcggga aagctcatcg ccagcacatg catcatctgt ggcatcttgg 1320 tggtggccct tcccatcacc atcatcttca acaagttttc caagtactac cagaagcaaa 1380 aggacattga tgtggaccag tgcagtgagg atgcaccaga gaagtgtcat gagctacctt 1440 actttaacat tagggatata tatgcacagc ggatgcacgc cttcattacc agtctctctt 1500 ctgtaggcat tgtggtgagc gatcctgact ccacagatgc ttcaagcatt gaagacaatg 1560 aggacatttg taacaccacc tccttggaga attgcacagc aaaatgagcg ggggtgtttg 1620 tgcctgtttc tcttatcctt tcccaacatt aggttaacac agctttataa acctcagtgg 1680 gttcgttaaa atcatttaat tctcagggtg tacctttcca gccatagttg gacattcatt 1740 gctgaattct gaaatgatag aattgtcttt atttttctct gtgaggtcaa ttaaatgcct 1800 tgttctgaaa tttatttttt acaagagaga gttgtgatat agtttggaat ataagataaa 1860 tggtattggg tggggtttgt ggctacagct tatgcatcat tctgtgtttg tcatttactc 1920 acattgagct aactttaaat tactgacaag tagaatcaaa ggtgcagctg actgagacga 1980 catgcatgta agatccacaa aatgagacaa tgcatgtaaa tccatgctca tgttctaaac 2040 atggaaacta ggagcctaat aaacttccta attcagtacg aaaaaaaaaa aaaaaaa 2097 <210> 131 <211> 2291 <212> DNA <213> Homo sapiens <400> 131 gaacaatgaa gaaagcccca cagccactgt tgctgagcag ggagaggata ttacctccaa 60 aaaagacagg ggagtattaa agattgtcaa aagagtgggg aatggtgagg aaacgccgat 120 gattggagac aaagtttatg tccattacaa aggaaaattg tcaaatggaa agaagtttga 180 ttccagtcat gatagaaatg aaccatttgt ctttagtctt ggcaaaggcc aagtcatcaa 240 ggcatgggac attggggtgg ctaccatgaa gaaaggagag atatgccatt tactgtgcaa 300 accagaatat gcatatggct cggctggcag tctccctaaa attccctcga atgcaactct 360 cttttttgag attgagctcc ttgatttcaa aggagaggat ttatttgaag atggaggcat 420 tatccggaga accaaacgga aaggagaggg atattcaaat ccaaacgaag gagcaacagt 480 agaaatccac ctggaaggcc gctgtggtgg aaggatgttt gactgcagag atgtggcatt 540 cactgtgggc gaaggagaag accacgacat tccaattgga attgacaaag ctctggagaa 600 aatgcagcgg gaagaacaat gtattttata tcttggacca agatatggtt ttggagaggc 660 agggaagcct aaatttggca ttgaacctaa tgctgagctt atatatgaag ttacacttaa 720 gagcttcgaa aaggccaaag aatcctggga gatggatacc aaagaaaaat tggagcaggc 780 tgccattgtc aaagagaagg gaaccgtata cttcaaggga ggcaaataca tgcaggcggt 840 gattcagtat gggaagatag tgtcctggtt agagatggaa tatggtttat cagaaaagga 900 atcgaaagct tctgaatcat ttctccttgc tgcctttctg aacctggcca tgtgctacct 960 gaagcttaga gaatacacca aagctgttga atgctgtgac aaggcccttg gactggacag 1020 tgccaatgag aaaggcttgt ataggagggg tgaagcccag ctgctcatga acgagtttga 1080 gtcagccaag ggtgactttg agaaagtgct ggaagtaaac ccccagaata aggctgcaag 1140 actgcagatc tccatgtgcc agaaaaaggc caaggagcac aacgagcggg accgcaggat 1200 atacgccaac atgttcaaga agtttgcaga gcaggatgcc aaggaagagg ccaataaagc 1260 aatgggcaag aagacttcag aaggggtcac taatgaaaaa ggaacagaca gtcaagcaat 1320 ggaagaagag aaacctgagg gccacgtatg acgccacgcc aaggagggaa gagtcccagt 1380 gaactcggcc cctcctcaat gggctttccc ccaactcagg acagaacagt gtttaatgta 1440 aagtttgtta tagtctatgt gattctggaa gcaaatggca aaaccagtag cttcccaaaa 1500 acagcccccc tgctgctgcc cggagggttc actgaggggt ggcacgggac cactccaggt 1560 ggaacaaaca gaaatgactg tggtgtggag ggagtgagcc agcagcttaa gtccagctca 1620 tttcagtttc tatcaacctt caagtatcca attcagggtc cctggagatc atcctaacaa 1680 tgtggggctg ttaggtttta cctttgaact ttcatagcac tgcagaaacc ttttaaaaaa 1740 aaatgcttca tgaatttctc ctttcctaca gttgggtagg gtaggggaag gaggataagc 1800 ttttgttttt taaatgactg aagtgctata aatgtagtct gttgcatttt taaccaacag 1860 aacccacagt agaggggtct catgtctccc cagttccaca gcagtgtcac agacgtgaaa 1920 gccagaacct cagaggccac ttgcttgctg acttagcctc ctcccaaagt ccccctcctc 1980 agccagcctc cttgtgagag tggctttcta ccacacacag cctgtccctg ggggagtaat 2040 tctgtcattc ctaaaacacc cttcagcaat gataatgagc agatgagagt ttctggatta 2100 gcttttccta ttttcgatga agttctgaga tactgaaatg tgaaaagagc aatcagaatt 2160 gtgctttttc tcccctcctc tattcctttt agggaataat attcaataca cagtacttcc 2220 tcccagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2280 aaaaaaaaaa a 2291 <210> 132 <211> 481 <212> DNA <213> Homo sapiens <400> 132 ccaaaaccac acagcttccc tttttattga tgctcaagaa gtgaacttta aatgacattt 60 cataagcaaa acacaaatga aaacacctaa tgtgcatgta tagtatatgt aaacatacat 120 agtatatgga ctcaatcatc ctcatctaaa tataaagaga acaactggtt ctttgacctc 180 aaaaataaat tcaatgttgg cattactgtt tttaacttac agtgttttat atttaacagg 240 aaaaattatg aataaccaag tttggtgtgg tcatggattt catgttaagg tataaataga 300 gtttttaaga aataatctgt ataataaaat aagtttactt ttgaatcgca gtacagtcat 360 ttccttcaat caataaaaat attccctgat tacaaagcag ccttattttg gcaaatggta 420 tttcaggaaa atagctctag caatatttga aataccacac tattttaaaa aggcngcgaa 480 g 481 <210> 133 <211> 489 <212> DNA <213> Homo sapiens <400> 133 ccatttgcag caatatattt tagttggctt gttgaaacac atctctcttc ctgaaagcaa 60 gcaattcttg aagtggatca accttgtcat catatccctt ttattcttca cccttttatt 120 cttcactggt atgacagtcc ctataccatc ttagccactg cttttttgtt tctacttatt 180 ttccatcccc cctgcctgcc cccccatagc aaaatgaagg catgccggga agcagcaact 240 caacataaaa agaggaccct ccaagcgatc agctcacaag acagttttat tgaattagtt 300 gcatgcagga gcaattctgt tcttcccatg agcagcagag tcgagtgtta gagtgcagga 360 tccagagcgg ggagaggctg ggcggagttg ggggcctgga ggctggggcc tggttacttg 420 gtgacgtgca gagctctctc tggggggctg cagctcatct tngggggagc ttgactcaga 480 tgcccccgt 489 <210> 134 <211> 2512 <212> DNA <213> Homo sapiens <400> 134 caatgcactg acggatatga gtgggatcct gtgagacagc aatgcaaaga tattgatgaa 60 tgtgacattg tcccagacgc ttgtaaaggt ggaatgaagt gtgtcaacca ctatggagga 120 tacctctgcc ttccgaaaac agcccagatt attgtcaata atgaacagcc tcagcaggaa 180 acacaaccag cagaaggaac ctcaggggca accaccgggg ttgtagctgc cagcagcatg 240 gcaaccagtg gagtgttgcc cgggggtggt tttgtggcca gtgctgctgc agtcgcaggc 300 cctgaaatgc agactggccg aaataacttt gtcatccggc ggaacccagc tgaccctcag 360 cgcattccct ccaacccttc ccaccgtatc cagtgtgcag caggctacga gcaaagtgaa 420 cacaacgtgt gccaagacat agacgagtgc actgcaggga cgcacaactg tagagcagac 480 caagtgtgca tcaatttacg gggatccttt gcatgtcagt gccctcctgg atatcagaag 540 cgaggggagc agtgcgtaga catagatgaa tgtaccatcc ctccatattg ccaccaaaga 600 tgcgtgaata caccaggctc attttattgc cagtgcagtc ctgggtttca attggcagca 660 aacaactata cctgcgtaga tataaatgaa tgtgatgcca gcaatcaatg tgctcagcag 720 tgctacaaca ttcttggttc attcatctgt cagtgcaatc aaggatatga gctaagcagt 780 gacaggctca actgtgaaga cattgatgaa tgcagaacct caagctacct gtgtcaatat 840 caatgtgtca atgaacctgg gaaattctca tgtatgtgcc cccagggata ccaagtggtg 900 agaagtagaa catgtcaaga tataaatgag tgtgagacca caaatgaatg ccgggaggat 960 gaaatgtgtt ggaattatca tggcggcttc cgttgttatc cacgaaatcc ttgtcaagat 1020 ccctacattc taacaccaga gaaccgatgt gtttgcccag tctcaaatgc catgtgccga 1080 gaactgcccc agtcaatagt ctacaaatac atgagcatcc gatctgatag gtctgtgcca 1140 tcagacatct tccagataca ggccacaact atttatgcca acaccatcaa tacttttcgg 1200 attaaatctg gaaatgaaaa tggagagttc tacctacgac aaacaagtcc tgtaagtgca 1260 atgcttgtgc tcgtgaagtc attatcagga ccaagagaac atatcgtgga cctggagatg 1320 ctgacagtca gcagtatagg gaccttccgc acaagctctg tgttaagatt gacaataata 1380 gtggggccat tttcatttta gtcttttcta agagtcaacc acaggcattt aagtcagcca 1440 aagaatattg ttaccttaaa gcactatttt atttatagat atatctagtg catctacatc 1500 tctatactgt acactcaccc ataacaaaca attacaccat ggtataaagt gggcatttaa 1560 tatgtaaaga ttcaaagttt gtctttatta ctatatgtaa attagacatt aatccactaa 1620 actggtcttc ttcaagagag ctaagtatac actatctggt gaaacttgga ttctttccta 1680 taaaagtggg accaagcaat gatgatcttc tgtggtgctt aaggaaactt actagagctc 1740 cactaacagt ctcataagga ggcagccatc ataaccattg aatagcatgc aagggtaaga 1800 atgagttttt aactgctttg taagaaaatg gaaaaggtca ataaagatat atttctttag 1860 aaaatgggga tctgccatat ttgtgttggt ttttattttc atatccagcc taaaggtggt 1920 tgtttattat atagtaataa atcattgctg tacaacatgc tggtttctgt agggtatttt 1980 taattttgtc agaaatttta gattgtgaat attttgtaaa aaacagtaag caaaattttc 2040 cagaattccc aaaatgaacc agataccccc tagaaaatta tactattgag aaatctatgg 2100 ggaggatatg agaaaataaa ttccttctaa accacattgg aactgacctg aagaagcaaa 2160 ctcggaaaat ataataacat ccctgaattc aggcattcac aagatgcaga acaaaatgga 2220 taaaaggtat ttcactggag aagttttaat ttctaagtaa aatttaaatc ctaacacttc 2280 actaatttat aactaaaatt tctcatcttc gtacttgatg ctcacagagg aagaaaatga 2340 tgatggtttt tattcctggc atccagagtg acagtgaact taagcaaatt accctcctac 2400 ccaattctat ggaatatttt atacgtctcc ttgtttaaaa tctgactgct ttactttgat 2460 gtatcatatt tttaaataaa aataaatatt cctttagaag atcactctaa aa 2512 <210> 135 <211> 541 <212> DNA <213> Homo sapiens <400> 135 tttttttttt tttaaatttt aatcttcatt gttttaattc tgaattttaa cgtgccacag 60 ggaaagtgag tttctttact gtttgccagc agcaaggaca aaaagtgaat ggggggggcc 120 caggagctcc cagcttggag agaaggccct tccaaaccca ggaacccggg gtttggggca 180 ggaggcagga aggatgggag ggtgtgatca caaacacaca cacacacgtt ctctctcttc 240 agggaagggt tttccagaag catttgccca tactctgaat gaagtatttt catgccaagc 300 caaacctcct gaagagaagt gaattcatgg ctgagggagc cacgtgccct ggctggggat 360 gcacctgaac gctgctcttc agcaagtgag ttcatagcat ccaccagagc ttcccagctc 420 ctcaagctga agacaggctg agcaaaaacc aggcaggcca tgaggggatt caaagaaacc 480 taataggatt gggtgcggtg gctcacacct gtaatcccag cactttggga ggccgaggcg 540 g 541 <210> 136 <211> 3890 <212> DNA <213> Homo sapiens <400> 136 atgaaggtga taagcttatt cattttggtg ggatttatag gagagttcca aagtttttca 60 agtgcctcct ctccagtcaa ctgccagtgg gacttctatg ccccttggtc agaatgcaat 120 ggctgtacca agactcagac tcgcaggcgg tcagttgctg tgtatgggca gtatggaggc 180 cagccttgtg ttggaaatgc ttttgaaaca cagtcctgtg aacctacaag aggatgtcca 240 acagaggagg gatgtggaga gcgtttcagg tgcttttcag gtcagtgcat cagcaaatca 300 ttggtttgca atggggattc tgactgtgat gaagacagtg ctgatgaaga cagatgtgag 360 gactcagaaa ggagaccttc ctgtgatatc gataaacctc ctcctaacat agaacttact 420 ggaaatggtt acaatgaact cactggccag tttaggaaca gagtcatcaa taccaaaagt 480 tttggtggtc aatgtagaaa ggtgtttagt ggggatggaa aagatttcta caggctgagt 540 ggaaatgtcc tgtcctatac attccaggtg aaaataaata atgattttaa ttatgaattt 600 tacaatagta cttggtctta tgtaaaacat acgtcgacag aacacacatc atctagtcgg 660 aagcgctcct tttttagatc ttcatcatct tcttcacgca gttatacttc acataccaat 720 gaaatccata aaggaaagag ttaccaactg ctggttgttg agaacactgt tgaagtggct 780 cagttcatta ataacaatcc agaattttta caacttgctg agccattctg gaaggagctt 840 tcccacctcc cctctctgta tgactacagt gcctaccgaa gattaatcga ccagtacggg 900 acacattatc tgcaatctgg gtcgttagga ggagaataca gagttctatt ttatgtggac 960 tcagaaaaat taaaacaaaa tgattttaat tcagtcgaag aaaagaaatg taaatcctca 1020 ggttggcatt ttgtcgttaa attttcaagt catggatgca aggaactgga aaacgcttta 1080 aaagctgctt caggaaccca gaacaatgta ttgcgaggag aaccgttcat cagaggggga 1140 ggtgcaggct tcatatctgg ccttagttac ctagagctgg acaatcctgc tggaaacaaa 1200 aggcgatatt ctgcctgggc agaatctgtg actaatcttc ctcaagtcat aaaacaaaag 1260 ctgacacctt tatatgagct ggtaaaggaa gtaccttgtg cctctgtgaa aaaactatac 1320 ctgaaatggg ctcttgaaga gtatctggat gaatttgacc cctgtcattg ccggccttgt 1380 caaaatggtg gtttggctac tgttgagggg acccattgtc tgtgccattg caaaccgtac 1440 acatttggtg cggcgtgtga gcaaggagtc ctcgtaggga atcaagcagg aggggttgat 1500 ggaggttgga gttgctggtc ctcttggagc ccctgtgtcc aagggaagaa aacaagaagc 1560 cgtgaatgca ataacccacc tcccagtggg ggtgggagat cctgcgttgg agaaacgaca 1620 gaaagcacac aatgcgaaga tgaggagctg gagcacttga ggttgcttga accacattgc 1680 tttcctttgt ctttggttcc aacagaattc tgtccatcac ctcctgcctt gaaagatgga 1740 tttgttcaag atgaaggtcc aatgtttcct gtggggaaaa atgtagtgta cacttgcaat 1800 gaaggatact ctcttattgg aaacccagtg gccagatgtg gagaagattt acggtggctt 1860 gttggggaaa tgcattgtca gaaaattgcc tgtgttctac ctgtactgat ggatggcata 1920 cagagtcacc cccaaaaacc tttctacaca gttggtgaga aggtgactgt ttcctgttca 1980 ggtggcatgt ccttagaagg tccttcagca tttctctgtg gctccagcct taagtggagt 2040 cctgagatga agaatgcccg ctgtgtacaa aaagaaaatc cgttaacaca ggcagtgcct 2100 aaatgtcagc gctgggagaa actgcagaat tcaagatgtg tttgtaaaat gccctacgaa 2160 tgtggacctt ccttggatgt atgtgctcaa gatgagagaa gcaaaaggat actgcctctg 2220 acagtttgca agatgcatgt tctccactgt cagggtagaa attacaccct tactggtagg 2280 gacagctgta ctctgcctgc ctcagctgag aaagcttgtg gtgcctgccc actgtgggga 2340 aaatgtgatg ctgagagcag caaatgtgtc tgccgagaag catcggagtg cgaggaagaa 2400 gggtttagca tttgtgtgga agtgaacggc aaggagcaga cgatgtctga gtgtgaggcg 2460 ggcgctctga gatgcagagg gcagagcatc tctgtcacca gcataaggcc ttgtgctgcg 2520 gaaacccagt aggctcctgg aggccatggt cagcttgctt ggaatccagc aggcagctgg 2580 ggctgagtga aaacatctgc acaactgggc actggacagc ttttccttct tctccagtgt 2640 ctaccttcct cctcaactcc cagccatctg tataaacaca atcctttgtt ctcccaaatc 2700 tgaatcgaat tactcttttg cctccttttt aatgtcagta aggatatgag cctttgcaca 2760 ggctggctgc gtgttcttga aataggtgtt accttctctg ggccttggtt ttttaaaatc 2820 tgtaaaatta gaggattgca ctagagaaac ttgaatgctc cattcaggcc tatcatttta 2880 ttaagtatga ttgacacagc ccatgggcca gaacacactc tacaaaatga ctaggataac 2940 agaaagaacg tgatctcctg attagagagg gtggttttcc tcaatggaac caaatataaa 3000 gaggacttga acaaaaatga cagatacaaa ctatttctat cctgagtagt aatctcacac 3060 ttcatcctat agagtcaacc accacagata ggaattcctt attctttttt taattttttt 3120 aagacagagt ctcactttgt tgcccaggct ggagcgcagt ggggtgatct catctccctg 3180 caacctccgc ctcctgggtt gaagcgattc ttgtgcctca gcttcccaag cagctgggat 3240 tacaggtgcc cgccaccacg cccagctaat ttttgcattt ttagtagaga tgggtttcac 3300 catgttggcc atgctcgtct ccaactcctg acctcaggta atccgtctgc cttggcctcc 3360 caaatgctgg gattacagac atgaaccacc acgcctggct ggaatactta ctcttgtcgg 3420 gagattgaac cactaaaatg ttagagcaga attcattatg ctgtggtcac aggggtgtct 3480 tgtctgagaa caaatacaat tcagtcttct ctttggggtt ttagtatgtg tcaaacatag 3540 gactggaagt ttgcccctgt tcttttttct tttgaaagaa catcagttca tgcctgaggc 3600 atgagtgact gtgcatttga gatagttttc cctattctgt ggatacagtc ccagagtttt 3660 cagggagtac acaggtagat tagtttgaag cattgacctt ttatttattc cttatttctc 3720 tttcatcaaa acaaaacagc agctgtggga ggagaaatga gagggcttaa atgaaattta 3780 aaataagcta tattatacaa atactatctc tgtattgttc tgaccctggt aaatatattt 3840 caaaacttca gatgacaagg attagaacac tcattaagat gctattcttc 3890 <210> 137 <211> 429 <212> DNA <213> Homo sapiens <400> 137 aggggttaca atccccttgc aaatattttt atagctatgg gaccctctcc tcagatctac 60 agccaacatt ttcagtgcac cttaggaggt cattttagtc cacgcctctg aaaaagctgc 120 actccaacgg ctgaagagca agccatacgg ccgagaatgg ggctcccttt gccttcatga 180 aagctacttc ccccaacact aagactcagc tgtacgtttg cttagctcag tcacatttac 240 attcttctgg gtgaactgta ccttttgagt acctgccttc attttctaga atcagaccta 300 acaaggtcag tagaagcctg gggcagcagc aggcctggga aagacgaggc agccagcatg 360 aactgctgtt ctctccctgg accacaaggc gtcgtcttcc tccagggtca agtaattgtt 420 ctttgttcc 429 <210> 138 <211> 1643 <212> DNA <213> Homo sapiens <400> 138 ggaattccct gatatacacc tggaccacca ccaatggata tacaaatggc aaacaatttt 60 actccgccct ctgcaactcc tcagggaaat gactgtgacc tctatgcaca tcacagcacg 120 gccaggatag taatgcctct gcattacagc ctcgtcttca tcattgggct cgtgggaaac 180 ttactagcct tggtcgtcat tgttcaaaac aggaaaaaaa tcaactctac caccctctat 240 tcaacaaatt tggtgatttc tgatatactt tttaccacgg ctttgcctac acgaatagcc 300 tactatgcaa tgggctttga ctggagaatc ggagatgcct tgtgtaggat aactgcgcta 360 gtgttttaca tcaacacata tgcaggtgtg aactttatga cctgcctgag tattgaccgc 420 ttcattgctg tggtgcaccc tctacgctac aacaagataa aaaggattga acatgcaaaa 480 ggcgtgtgca tatttgtctg gattctagta tttgctcaga cactcccact cctcatcaac 540 cctatgtcaa agcaggaggc tgaaaggatt acatgcatgg agtatccaaa ctttgaagaa 600 actaaatctc ttccctggat tctgcttggg gcatgtttca taggatatgt acttccactt 660 ataatcattc tcatctgcta ttctcagatc tgctgcaaac tcttcagaac tgccaaacaa 720 aacccactca ctgagaaatc tggtgtaaac aaaaaggctc tcaacacaat tattcttatt 780 attgttgtgt ttgttctctg tttcacacct taccatgttg caattattca acatatgatt 840 aagaagcttc gtttctctaa tttcctggaa tgtagccaaa gacattcgtt ccagatttct 900 ctgcacttta cagtatgcct gatgaacttc aattgctgca tggacccttt tatctacttc 960 tttgcatgta aagggtataa gagaaaggtt atgaggatgc tgaaacggca agtcagtgta 1020 tcgatttcta gtgctgtgaa gtcagcccct gaagaaaatt cacgtgaaat gacagaaacg 1080 cagatgatga tacattccaa gtcttcaaat ggaaagtgaa atggattgta ttttggttta 1140 tagtgacgta aactgtatga caaactttgc aggacttccc ttataaagca aaataattgt 1200 tcagcttcca attagtattc ttttatattt ctttcattgg gcgctttccc atctccaact 1260 cggaagtaag cccaagagaa caacataaag caaacaacat aaagcacaat aaaaatgcaa 1320 ataaatattt tcatttttat ttgtaaacga atacaccaaa aggaggcgct cttaataact 1380 cccaatgtaa aaagttttgt tttaataaaa aattaattat tattcttgcc aacaaatggc 1440 tagaaaggac tgaatagatt atatattgcc agatgttaat actgtaacat actttttaaa 1500 taacatattt cttaaatcca aatttctctc aatgttagat ttaattccct caataacacc 1560 aatgttttgt tttgtttcgt tctgggtcat aaaactttgt taaggaactc ttttggaata 1620 aagagcagga tgctgcggaa ttc 1643 <210> 139 <211> 1398 <212> DNA <213> Homo sapiens <400> 139 tagatggcaa cctccctatc tgcccgcagg tcatagaggc gacacgtagc gtcatctgac 60 cctgaagcaa aggcatctcc actccaaagt tagacaaaat gccaggaatg ttcttctctg 120 ctaacccaaa ggaattgaaa ggaaccactc attcacttct agacgacaaa atgcaaaaaa 180 ggaggccaaa gacttttgga atggatatga aagcatacct gagatctatg atcccacatc 240 tggaatctgg aatgaaatct tccaagtcca aggatgtact ttctgctgct gaagtaatgc 300 aatggtctca atctctggaa aaacttcttg ccaaccaaac tggtcaaaat gtctttggaa 360 gtttcctaaa gtctgaattc agtgaggaga atattgagtt ctggctggct tgtgaagact 420 ataagaaaac agagtctgat cttttgccct gtaaagcaga agagatatat aaagcatttg 480 tgcattcaga tgctgctaaa caaatcaata ttgacttccg cactcgagaa tctacagcca 540 agaagattaa agcaccaacc cccacgtgtt ttgatgaagc acaaaaagtc atatatactc 600 ttatggaaaa ggactcttat cccaggttcc tcaaatcaga tatttactta aatcttctaa 660 atgacctgca ggctaatagc ctaaagtgac tggtccctgg ctgaagggaa ttaacagata 720 gtatcaaggc acgaaggaat gtgccagtat ggctccctgg gtgaacagct tggccttttt 780 tgggtgtctt gacaggccaa gaagaacaaa tgactcagaa tggattaaca tgaaagttat 840 ccaggcgcag agttgaagaa gcataagcaa gacaaaaaca gagagaccgc agaaggagga 900 agatactgtg gtactgtcat aaaaaacagt ggagctctgt attagaaagc ccctcagaac 960 tgggaaggcc aggtaactct agttacacag aaactgtgac taaagtctat gaaactgatt 1020 acaacaggct gtaagaatca aagtcaactg acatctatgc tacatattat tatatagttt 1080 gtactgagct attgaagtcc cattaactta aagtatatgt tttcaaattg ccattgctac 1140 tattgcttgt cggtgtattt tattttattg tttttgactt tggaagagat gaactgtgta 1200 tttaacttaa gctattgctc ttaaaaccag ggatcagaat atatttgtaa gttaaatcat 1260 tggtgctaat aataaatgtg gattttgtat taaaatatat agaagcaatt tctgtttaca 1320 tgtccttgct acttttaaaa acttgcattt attcctcaga ttttaaaaat aaataaataa 1380 ttcatttaaa aaaaaaaa 1398 <210> 140 <211> 479 <212> DNA <213> Homo sapiens <400> 140 tttttattga tcaaagagag aatttattca cagagatttt caaatacaaa caaaatagca 60 cttttaaatt ttttacaaaa tgaatataga aataaatgtg gtacagcaca gtacaataat 120 ggacaaaaga aaacacgatc caatgactgg aaaatgtctc tcattactct catatcttcg 180 gctgaattct ctcctatagt ggacagaaag ttgccccttt tcttcataag aatatcatag 240 cagaagctac tcagagaaat attgcatatt gtggaataac atggaaatac aaaggcttaa 300 ctctaaaggt ctgcataaac actgaaaata agttgaggaa ctaaattaga gtttatgcag 360 gatatacaaa atactgatag tttggcttat tggtccattt attaggctta atgtatgttt 420 tataaagtga taatactgta ttttaaatgt atattaaaaa gaaaacagag gagaaatgc 479 <210> 141 <211> 1651 <212> DNA <213> Homo sapiens <400> 141 ggagcccccg ccctgggatt cccaggtgtt ttcatttggt gatcagcact gaacacagaa 60 gagtcatgac ggagtttggg ctgagctggg ttttccttgt tgctattttt aaaggtgtcc 120 agtgtgaggt gcagctggtg gagtctgggg gagacttggt ccagcctggg gggtccctga 180 gactctcctg tgcagcctct ggattcacct tcagtagtta tgctatgcac tgggtccgcc 240 aggctccagg gaagggactg aaatatgttt caggtattag tagtaatggg cgtagaacat 300 attatgcaaa ttctgtgaag ggcagattca ccatctccag agacaattcc aagaacacgt 360 tgtatcttca aatgggcagc ctgagagctg aggacatggc tgtgtattac tgtgtgtccg 420 ggggaatcta tgatagtagt ggtccctttg actactgggg ccagggaacc ctggtcaccg 480 tctcctcagc atccccgacc agccccaagg tcttcccgct gagcctctgc agcacccagc 540 cagatgggaa cgtggtcatc gcctgcctgg tccagggctt cttcccccag gagccactca 600 gtgtgacctg gagcgaaagc ggacagggcg tgaccgccag aaacttccca cccagccagg 660 atgcctccgg ggacctgtac accacgagca gccagctgac cctgccggcc acacagtgcc 720 tagccggcaa gtccgtgaca tgccacgtga agcactacac gaatcccagc caggatgtga 780 ctgtgccctg cccagttccc tcaactccac ctaccccatc tccctcaact ccacctaccc 840 catctccctc atgctgccac ccccgactgt cactgcaccg accggccctc gaggacctgc 900 tcttaggttc agaagcgaac ctcacgtgca cactgaccgg cctgagagat gcctcaggtg 960 tcaccttcac ctggacgccc tcaagtggga agagcgctgt tcaaggacca cctgagcgtg 1020 acctctgtgg ctgctacagc gtgtccagtg tcctgccggg ctgtgccgag ccatggaacc 1080 atgggaagac cttcacttgc actgctgcct accccgagtc caagaccccg ctaaccgcca 1140 ccctctcaaa atccggaaac acattccggc ccgaggtcca cctgctgccg ccgccgtcgg 1200 aggagctggc cctgaacgag ctggtgacgc tgacgtgcct ggcacgcggc ttcagcccca 1260 aggacgtgct ggttcgctgg ctgcaggggt cacaggagct gccccgcgag aagtacctga 1320 cttgggcatc ccggcaggag cccagccagg gcaccaccac cttcgctgtg accagcatac 1380 tgcgcgtggc agccgaggac tggaagaagg gggacacctt ctcctgcatg gtgggccacg 1440 aggccctgcc gctggccttc acacagaaga ccatcgaccg cttggcgggt aaacccaccc 1500 atgtcaatgt gtctgttgtc atggcggagg tggacggcac ctgctactga gccgcccgcc 1560 tgtccccacc cctgaataaa ctccatgctc ccccaaaaaa aaaaaaaaaa aaaaaaaaaa 1620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1651 <210> 142 <211> 492 <212> DNA <213> Homo sapiens <400> 142 tttttttata acctcaaagt cagcactccc agttgggtgt tttattattt atttacttga 60 caggtaacat cgatttggtc ctacaagaca ccatgctata ggcttagcta cttgctgttg 120 cacaagagaa ctttcctgaa ctctcaggaa gcccttgcat ggcctatcga ggacagctca 180 gtcactgaag ggaaaaattc cataccaaag aagagagaaa aattccatac caaagaacag 240 acttccccca gggaacctcc gtcctacagc ccttcagggc catcacactc acacacatca 300 gccatcatca aaatagtggc catgctggga agaacaggag tcctgaacta gaaggtggtc 360 ttcaaaccat ggcgtaccga tttatgtata ttacagatag ataaattaag aggtctacat 420 gaataaaaaa tctctcaaag gggaacgaat tccattctgt catgccaggt gtttgtcaga 480 accttgaaaa cg 492 <210> 143 <211> 392 <212> DNA <213> Homo sapiens <400> 143 cggcacgagg agctggcctg tgacctgaac catgctcctt gcatccagaa agctgctgaa 60 ctcttctccc agtggatgga atccagtgga aaattaaagt agatgtagac ttctgtccta 120 ccctttgttc ttttctcttt gatgtaaaag tctttgatca agcaagacat taggtctaaa 180 accttttagt gaggatagaa aaaaaaacat gctgggcatt acaaaccctg tttcatgctc 240 ttcacattgt aagtgctatg tatgggagga ctagtacaat cttctaccct ggaaatgtaa 300 tggtgtccct ttnttcccgt gctggcttgg ggtgcagtng gccccacgcc ttttaattcc 360 ccgggaantt tgggggagga ccaagggngg gg 392 <210> 144 <211> 328 <212> DNA <213> Homo sapiens <400> 144 cacatttttt ggggatatga actagatgtt caagaactcc ttctggactg tggatactga 60 atcagtgtac tattggctgc agaatttgtt tcaattgaaa atagactcag gaagattgct 120 gctcagaata tcatataatg tttatttttt gaggtgtttt tgtttttatt tgtgtgtttt 180 ttttttttta agtcagcttg gaactttttt cctgggtagt atttgggaga gggaaaggct 240 gtactatata tttatttcta aatgttttga ctgggcattt ttcttttaat gaaatatgtg 300 gactgctcta gcaaacccta ttttcagc 328 <210> 145 <211> 8062 <212> DNA <213> Homo sapiens <400> 145 cgtccctgca gccctcgccc ggcgctccag tagcaggacc cggtctcggg accagccggt 60 aatatgcacg tgtcactagc tgaggccctg gaggttcggg gtggaccact tcaggaggaa 120 gaaatatggg ctgtattaaa tcaaagtgct gaaagtctcc aagaattatt cagaaaagta 180 agcctagctg atcctgctgc ccttggcttc atcatttctc catggtctct gctgttgctg 240 ccatctggta gtgtgtcatt tacagatgaa aatatttcca atcaggatct tcgagcattc 300 actgcaccag aggttcttca aaatcagtca ctaacttctc tctcagatgt tgaaaagatc 360 cacatttatt ctcttggaat gacactgtat tggggggctg attatgaagt gcctcagagc 420 caacctatta agcttggaga tcatctcaac agcatactgc ttggaatgtg tgaggatgtt 480 atttacgctc gagtttctgt tcggactgtg ctggatgctt gcagtgccca cattaggaat 540 agcaattgtg caccctcatt ttcctacgtg aaacacttgg taaaactggt tctgggaaat 600 ctttctggga cagatcagct ttcctgtaac agtgaacaaa agcctgatcg aagccaggct 660 attcgagatc gattgcgagg aaaaggatta ccaacaggaa gaagctctac ttctgatgta 720 ctagacatac aaaagcctcc actctctcat cagacctttc ttaacaaagg gcttagtaaa 780 tctatgggat ttctgtccat caaagataca caagatgaga attatttcaa ggacatttta 840 tcagataatt ctggacgtga agattctgaa aatacattct ccccttacca gttcaaaact 900 agtggcccag aaaaaaaacc catccctggc attgatgtgc tttctaagaa gaagatctgg 960 gcttcatcca tggacttgct ttgtacagct gacagagact tctcttcagg agagactgcc 1020 acatatcgtc gttgtcaccc tgaggcagta acagtgcgga cttcaactac tcctagaaaa 1080 aaggaggcaa gatactcaga tggaagtata gccttggata tctttggccc tcagaaaatg 1140 gatccaatat atcacactcg agaattgccc acctcctcag caatatcaag tgctttggac 1200 cgaatccgag agagacaaaa gaaacttcag gttctgaggg aagccatgaa tgtagaagaa 1260 ccagttcgaa gatacaaaac ttatcatggt gatgtcttta gtacctccag tgaaagtcca 1320 tctattattt cctctgaatc agatttcaga caagtgagaa gaagtgaagc ctcaaagagg 1380 tttgaatcca gcagtggtct cccaggggta gatgaaacct taagtcaagg ccagtcacag 1440 agaccgagca gacaatatga aacacccttt gaaggcaact taattaatca agagatcatg 1500 ctaaaacggc aagaggaaga actgatgcag ctacaagcca aaatggccct tagacagtct 1560 cggttgagcc tatatccagg agacacaatc aaagcgtcca tgcttgacat caccagggat 1620 ccgttaagag aaattgccct agaaacagcc atgactcaaa gaaaactgag gaatttcttt 1680 ggccctgagt ttgtgaaaat gacaattgaa ccatttatat ctttggattt gccacggtct 1740 attcttacta agaaagggaa gaatgaggat aaccgaagga aagtaaacat aatgcttctg 1800 aacgggcaaa gactggaact gacctgtgat accaaaacta tatgtaaaga tgtgtttgat 1860 atggttgtgg cacatattgg cttagtagag catcatttgt ttgctttagc taccctcaaa 1920 gataatgaat atttctttgt tgatcctgac ttaaaattaa ccaaagtggc cccagaggga 1980 tggaaagaag aaccaaagaa aaagaccaaa gccactgtta attttacttt gtttttcaga 2040 attaaatttt ttatggatga tgttagtcta atacaacata ctctgacgtg tcatcagtat 2100 taccttcagc ttcgaaaaga tattttggag gaaaggatgc actgtgatga tgagacttcc 2160 ttattgctgg catccttggc tctccaggct gagtatggag attatcaacc agaggttcat 2220 ggtgtgtctt actttagaat ggagcactat ttgcccgcca gagtgatgga gaaacttgat 2280 ttatcctata tcaaagaaga gttacccaaa ttgcataata cctatgtggg agcttctgaa 2340 aaagagacag agttagaatt tttaaaggtc tgccaaagac tgacagaata tggagttcat 2400 tttcaccgag tgcaccctga gaagaagtca caaacaggaa tattgcttgg agtctgttct 2460 aaaggtgtcc ttgtgtttga agttcacaat ggagtgcgca cattggtcct tcgctttcca 2520 tggagggaaa ccaagaaaat atctttttct aaaaagaaaa tcacattgca aaatacatca 2580 gatggaataa aacatggctt ccagacagac aacagtaaga tatgccagta cctgctgcac 2640 ctctgctctt accagcataa gttccagcta cagatgagag caagacagag caaccaagat 2700 gcccaagata ttgagagagc ttcgtttagg agcctgaatc tccaagcaga gtctgttaga 2760 ggatttaata tgggacgagc aatcagcact ggcagtctgg ccagcagcac cctcaacaaa 2820 cttgctgttc gacctttatc agttcaagct gagattctga agaggctatc ctgctcagag 2880 ctgtcgcttt accagccatt gcaaaacagt tcaaaagaga agaatgacaa agcttcatgg 2940 gaggaaaagc ctagagagat gagtaaatca taccatgatc tcagtcaggc ctctctctat 3000 ccacatcgga aaaatgtcat tgttaacatg gaacccccac cacaaaccgt tgcagagttg 3060 gtgggaaaac cttctcacca gatgtcaaga tctgatgcag aatctttggc aggagtgaca 3120 aaacttaata attcaaagtc tgttgcgagt ttaaatagaa gtcctgaaag gaggaaacat 3180 gaatcagact cctcatccat tgaagaccct gggcaagcat atgttctaga tgtgctacac 3240 aaaagatgga gcatagtatc ttcaccagaa agggagatca ccttagtgaa cctgaaaaaa 3300 gatgcaaagt atggcttggg atttcaaatt attggtgggg agaagatggg aagactggac 3360 ctaggcatat ttatcagttc agttgcccct ggaggaccag ctgacttgga tggatgcttg 3420 aagccaggag accgtttgat atctgtgaat agtgtgagtc tggagggagt cagccaccat 3480 gctgcaattg aaattttgca aaatgcacct gaagatgtga cacttgttat ctctcagcca 3540 aaagaaaaga tatccaaagt gccttctact cctgtgcatc tcaccaatga gatgaaaaac 3600 tacatgaaga aatcttccta catgcaagac agtgctatag attcttcttc caaggatcac 3660 cactggtcac gtggtaccct gaggcacatc tcggagaact cctttgggcc atctgggggc 3720 ctgcgggaag gaagcctgag ttctcaagat tccaggactg agagtgccag cttgtctcaa 3780 agccaggtca atggtttctt tgccagccat ttaggtgacc aaacctggca ggaatcacag 3840 catggcagcc cttccccatc tgtaatatcc aaagccaccg agaaagagac tttcactgat 3900 agtaaccaaa gcaaaactaa aaagccaggc atttctgatg taactgatta ctcagaccgt 3960 ggagattcag acatggatga agccacttac tccagcagtc aggatcatca aacaccaaaa 4020 caggaatctt cctcttcagt gaatacatcc aacaagatga attttaaaac tttttcttca 4080 tcacctccta agcctggaga tatctttgag gttgaactgg ctaaaaatga taacagcttg 4140 gggataagtg tcacgggagg tgtgaatacg agtgtcagac atggtggcat ttatgtgaaa 4200 gctgttattc cccagggagc agcagagtct gatggtagaa ttcacaaagg tgatcgcgtc 4260 ctagctgtca atggagttag tctagaagga gccacccata agcaagctgt ggaaacactg 4320 agaaatacag gacaggtggt tcatctgtta ttagaaaagg gacaatctcc aacatctaaa 4380 gaacatgtcc cggtaacccc acagtgtacc ctttcagatc agaatgccca aggtcaaggc 4440 ccagaaaaag tgaagaaaac aactcaggtc aaagactaca gctttgtcac tgaagaaaat 4500 acatttgagg taaaattatt taaaaatagc tcaggtctag gattcagttt ttctcgagaa 4560 gataatctta taccggagca aattaatgcc agcatagtaa gggttaaaaa gctctttcct 4620 ggacagccag cagcagaaag tggaaaaatt gatgtaggag atgttatctt gaaagtgaat 4680 ggagcctctt tgaaaggact atctcagcag gaagtcatat ctgctctcag gggaactgct 4740 ccagaagtat tcttgcttct ctgcagacct ccacctggtg tgctaccgga aattgatact 4800 gcgcttttga ccccacttca gtctccagca caagtacttc caaacagcag taaagactct 4860 tctcagccat catgtgtgga gcaaagcacc agctcagatg aaaatgaaat gtcagacaaa 4920 agcaaaaaac agtgcaagtc cccatccaga agagacagtt acagtgacag cagtgggagt 4980 ggagaagatg acttagtgac agctccagca aacatatcaa attcgacctg gagttcagct 5040 ttgcatcaga ctctaagcaa catggtatca caggcacaga gtcatcatga agcacccaag 5100 agtcaagaag ataccatttg taccatgttt tactatcctc agaaaattcc caataaacca 5160 gagtttgagg acagtaatcc ttcccctcta ccaccggata tggctcctgg gcagagttat 5220 caaccccaat cagaatctgc ttcctctagt tcgatggata agtatcatat acatcacatt 5280 tctgaaccaa ctagacaaga aaactggaca cctttgaaaa atgacttgga aaatcacctt 5340 gaagactttg aactggaagt agaactcctc attaccctaa ttaaatcaga aaaaggaagc 5400 ctgggtttta cagtaaccaa aggcaatcag agaattggtt gttatgttca tgatgtcata 5460 caggatccag ccaaaagtga tggaaggcta aaacctgggg accggctcat aaaggttaat 5520 gatacagatg ttactaatat gactcataca gatgcagtta atctgctccg ggctgcatcc 5580 aaaacagtca gattagttat tggacgagtt ctagaattac ccagaatacc aatgttgcct 5640 catttgctac cggacataac actaacgtgc aacaaagagg agttgggttt ttccttatgt 5700 ggaggtcatg acagccttta tcaagtggta tatattagtg atattaatcc aaggtccgtc 5760 gcagccattg agggtaatct ccagctatta gatgtcatcc attatgtgaa cggagtcagc 5820 acacaaggaa tgaccttgga ggaagttaac agagcattag acatgtcact tccttcattg 5880 gtattgaaag caacaagaaa tgatcttcca gtggtcccca gctcaaagag gtctgctgtt 5940 tcagctccaa agtcaaccaa aggcaatggt tcctacagtg tggggtcttg cagccagcct 6000 gccctcactc ctaatgattc attctccacg gttgctgggg aagaaataaa tgaaatatcg 6060 taccccaaag gaaaatgttc tacttatcag ataaagggat caccaaactt gactctgccc 6120 aaagaatctt atatacaaga agatgacatt tatgatgatt cccaagaagc tgaagttatc 6180 cagtctctgc tggatgttgt ggatgaggaa gcccagaatc ttttaaacga aaataatgca 6240 gcaggatact cctgtggtcc aggtacatta aagatgaatg ggaagttatc agaagagaga 6300 acagaagata cagactgcga tggttcacct ttacctgagt attttactga ggccaccaaa 6360 atgaatggct gtgaagaata ttgtgaagaa aaagtaaaaa gtgaaagctt aattcagaag 6420 ccacaagaaa agaagactga tgatgatgaa ataacatggg gaaatgatga gttgccaata 6480 gagagaacaa accatgaaga ttctgataaa gatcattcct ttctgacaaa cgatgagctc 6540 gctgtactcc ctgtcgtcaa agtgcttccc tctggtaaat acacgggtgc caacttaaaa 6600 tcagtcattc gagtcctgcg gggtttgcta gatcaaggaa ttccttctaa ggagctggag 6660 aatcttcaag aattaaaacc tttggatcag tgtctaattg ggcaaactaa ggaaaacaga 6720 aggaagaaca gatataaaaa tatacttccc tatgatgcta caagagtgcc tcttggagat 6780 gaaggtggct atatcaatgc cagcttcatt aagataccag ttgggaaaga agagttcgtt 6840 tacattgcct gccaaggacc actgcctaca actgttggag acttctggca gatgatttgg 6900 gagcaaaaat ccacagtgat agccatgatg actcaagaag tagaaggaga aaaaatcaaa 6960 tgccagcgct attggcccaa catcctaggc aaaacaacaa tggtcagcaa cagacttcga 7020 ctggctcttg tgagaatgca gcagctgaag ggctttgtgg tgagggcaat gacccttgaa 7080 gatattcaga ccagagaggt gcgccatatt tctcatctga atttcactgc ctggccagac 7140 catgatacac cttctcaacc agatgatctg cttactttta tctcctacat gagacacatc 7200 cacagatcag gcccaatcat tacgcactgc agtgctggca ttggacgttc agggaccctg 7260 atttgcatag atgtggttct gggattaatc agtcaggatc ttgattttga catctctgat 7320 ttggtgcgct gcatgagact acaaagacac ggaatggttc agacagagga tcaatatatt 7380 ttctgctatc aagtcatcct ttatgtcctg acacgtcttc aagcagaaga agagcaaaaa 7440 cagcagcctc agcttctgaa gtgacatgaa aagagcctct ggatgcattt ccatttctct 7500 ccttaacctc cagcagactc ctgctctcta tccaaaataa agatcacaga gcagcaagtt 7560 catacaacat gcatgttctc ctctatctta gaggggtatt cttcttgaaa ataaaaaata 7620 ttgaaatgct gtatttttac agctacttta acctatgata attatttaca aaattttaac 7680 actaaccaaa caatgcagat cttagggatg attaaaggca gcatttgatg atagcagaca 7740 ttgttacaag gacatggtga gtctattttt aatgcaccaa tcttgtttat agcaaaaatg 7800 ttttccaata ttttaataaa gtagttattt tataggggat acttgaaacc agtatttaag 7860 ctttaaatga cagtaatatt ggcatagaaa aaagtagcaa atgtttactg tatcaatttc 7920 taatgtttac tatatagaat ttcctgtaat atatttatat actttttcat gaaaatggag 7980 ttatcagtta tctgtttgtt actgcatcat ctgtttgtaa tcattatctc actttgtaaa 8040 taaaaacaca ccttaaaaca tg 8062 <210> 146 <211> 2306 <212> DNA <213> Homo sapiens <400> 146 gggcgggagc tgcacgcgcc gtggctccgg atctcttcgt ctttgcagcg tacgcccgag 60 tcggtcagcg ccggaggacc tcagcagcca tgtcgaagcc ccatagtgaa gccgggactg 120 ccttcattca gacccagcag ctgcacgcag ccatggctga cacattcctg gagcacatgt 180 gccgcctgga cattgattca ccacccatca cagcccggaa cactggcatc atctgtacca 240 ttggcccagc ttcccgatca gtggagacgt tgaaggagat gattaagtct ggaatgaatg 300 tggctcgtct gaacttctct catggaactc atgagtacca tgcggagacc atcaagaatg 360 tgcgcacagc cacggaaagc tttgcttctg acccctacct ctaccggccc gttgctgtgg 420 ctctagacac taaaggacct gagatccgaa ctgggctcat caagggcagc ggcactgcag 480 agctggagct gaagaaggga gccactctca aaatcacgct ggataacgcc tacatggaaa 540 agtgtgacga gaacatcctg tggctggact acaagaacat ctgcaaggtg gtggaagtgg 600 gcagcaagat ctacgtggat gatgggctta tttctctcca ggtgaagcag aaaggtgccg 660 acttcctggt gacggaggtg gaaaatggtg gctccttggg cagcaagaag ggtgtgaacc 720 ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa ggacatccag gatctgaagt 780 ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt catccgcaag gcatctgatg 840 tccatgaagt taggaaggtc ctgggagaga agggaaagaa catcaagatt atcagcaaaa 900 tcgagaatca tgagggggtt cggaggtttg atgaaatcct ggaggccagt gatgggatca 960 tggtggctcg tggtgatcta ggcattgaga ttcctgcaga gaaggtcttc cttgctcaga 1020 agatgatgat tggacggtgc aaccgagctg ggaagcctgt catctgtgct actcagatgc 1080 tggagagcat gatcaagaag ccccgcccca ctcgggctga aggcagtgat gtggccaatg 1140 cagtcctgga tggagccgac tgcatcatgc tgtctggaga aacagccaaa ggggactatc 1200 ctctggaggc tgtgcgcatg cagcacctga ttgcccgtga ggcagaggct gccatctacc 1260 acttgcaatt atttgaggaa ctccgccgcc tggcgcccat taccagcgac cccacagaag 1320 ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg cagtggggcc ataatcgtcc 1380 tcaccaagtc tggcaggtct gctcaccagg tggccagata ccgcccacgt gcccccatca 1440 ttgctgtgac ccggaatccc cagacagctc gtcaggccca cctgtaccgt ggcatcttcc 1500 ctgtgctgtg caaggaccca gtccaggagg cctgggctga ggacgtggac ctccgggtga 1560 actttgccat gaatgttggc aaggcccgag gcttcttcaa gaagggagat gtggtcattg 1620 tgctgaccgg atggcgccct ggctccggct tcaccaacac catgcgtgtt gttcctgtgc 1680 cgtgatggac cccagagccc ctcctccagc ccctgtccca cccccttccc ccagcccatc 1740 cattaggcca gcaacgcttg tagaactcac tctgggctgt aacgtggcac tggtaggttg 1800 ggacaccagg gaagaagatc aacgcctcac tgaaacatgg ctgtgtttgc agcctgctct 1860 agtgggacag cccagagcct ggctgcccat catgtggccc cacccaatca agggaagaag 1920 gaggaatgct ggactggagg cccctggagc cagatggcaa gagggtgaca gcttcctttc 1980 ctgtgtgtac tctgtccagt tcctttagaa aaaatggatg cccagaggac tcccaaccct 2040 ggcttggggt caagaaacag ccagcaagag ttaggggcct tagggcactg ggctgttgtt 2100 ccattgaagc cgactctggc cctggccctt acttgcttct ctagctctct aggcctctcc 2160 agtttgcacc tgtccccacc ctccactcag ctgtcctgca gcaaacactc caccctccac 2220 cttccatttt cccccactac tgcagcacct ccaggcctgt tgctatagag cctacctgta 2280 tgtcaataaa caacagctga agcacc 2306 <210> 147 <211> 498 <212> DNA <213> Homo sapiens <400> 147 tttttttttt ttttttaaat taaatacagg gaagacacta agcaaacact ggtccaatgg 60 gggctctcct cacttcccga gatggtcaaa tggcacactt gtctgtgagg ctgggatccg 120 ggaaacctct tgccgcccag tgaggtctga ggaggagaca ttggcgggcg cacccctgtg 180 caacctcata ctcaccttcc tctcccggtc aacccgcgaa atcgctctgg gagaagtatt 240 gccagccggc tggatgcagg aggctggcat ggaagccacg ggctcagcgg cactgcggaa 300 ccggttggca atggcccccg tgggtgggcc aaggggcatg gctcgggtcg cggacccccc 360 taactgcccc atcctctcct cacattcatg ttctcaccac tcccagtcca catcctctgg 420 attccaggct gcaccaaatt tcagcatgtt ccatccaaac acatagtcat atgagaagcc 480 ctgccagtgg aagaagtt 498 <210> 148 <211> 11893 <212> DNA <213> Homo sapiens <400> 148 ccgcgcgtcc ctgtgcgtcc ccgggtccct gcgggcgggc gggcgcggtc gccgccgagc 60 aacccggcct gcgcccggca cgactgtaga tgtcaggctt tgcccgggga gccgagcggc 120 agcggggctg tgagtttcaa attaaccttc cgctttgttg ctgtgtaatg tggatccccg 180 aaggcccccc gccccgcccg ccccccttcc ccgggcggtg cgcgctgcaa actgcgagtt 240 gggcttcatt tacataaagc gattccgggc gggcggcgga agaggaggag gcggcggcgg 300 cgggcaggcc ggggacccgg acgccagcgc cgcgccccgt gggtgaatcc ccgccgcgtc 360 ccggggacct ccctccgggg acgggccgac cgccagccct gccgccacca tgagctcccc 420 tcccctgtct ccgggccccc tgctcctgac cagagccacc tccgagtcct ggggccagcg 480 ggaggtgggg agcataccgc ctggggtggg tgagctcggg gctcgggtgc cactggaatt 540 tcccgttgtt gcgcatggcg gcgcggcccc cggacctgca agtgccgcct ccctccggag 600 gtgcgcggag gcttggtgtg ccaggtccga gcctccgtac tgggtgcaat gaaagctcca 660 cgcaggcctt accatggaag gctgtgactc gcccgtcgtc tcggggaagg acaatgggtg 720 cggtatccct cagcaccagc aatggactga actcaacagc acccacctcc ctgacaaacc 780 cagtagcatg gaacagtcca caggcgagag ccacgggccc ttggacagcc tgagggcccc 840 cttcaatgag cgcctcgcgg agagcaccgc gtcggccggg ccccccgccg agcccgccag 900 caaggaggtc acctgcaacg aatgttcggc ctcctttgcc agcctccaga cctacatgga 960 gcaccactgc cccagcgcgc gccccccgcc acccctgaga gaggagagcg ctagcgacac 1020 cggtgaggag ggggacgagg agagtgacgt ggagaacctg gccggggaga tcgtctacca 1080 gccggacggc tccgcataca ttgtggagag cctgagccag ctgacccagg gcgggggcgc 1140 ctgtgggagt ggcagtggca gtgggcctct cccctcgctt ttcctgaact ctctccctgg 1200 cgcggggggc aagcaagggg acccttcgtg tgctgcaccc gtgtacccgc agatcatcaa 1260 cactttccac atagcctcat ccttcgggaa atggtttgag ggcccagacc aggctttccc 1320 gaatacctca gccctggcgg ggctcagccc cgtcctgcac agcttccgcg tgtttgacgt 1380 gcgacacaaa agcaacaagg attacctgaa cagcgacggt tctgccaaaa gctcctgcgt 1440 atccaaagat gttcccaaca atgtggacct gtccaaattc gatggctttg tgctctatgg 1500 caagaggaag cccatcctga tgtgtttctt gtgcaaactc tcctttgggt acgtccgttc 1560 gtttgtgacc cacgcggtgc atgaccatcg aatgaccctg agcgaagacg agcggaaaat 1620 tcttagcaat aagaacatct ccgctatcat ccaagggatc ggcaaagaca aggaacccct 1680 tgtaagtttt ctggaaccaa aaaacaaaaa ctttcaacac cctttagttt ccacagctaa 1740 cctcataggc cccggacaca gtttttatgg taaatttagt ggcattcgaa tggaagggga 1800 ggaagctctc ccagcgggct ccgccgctgg ccccgagcag ccccaggctg gtctcttgac 1860 ccccagcacc ctgttgaacc ttggcgggct caccagctcg gtactgaaga cccccattac 1920 ctcagtcccc ctgggggctc tggcttccag tcctaccaaa tcctcagagg gcaaggactc 1980 tggggcggca gaaggagaga agcaggaagt gggcgacggg gattgcttct ctgagaaggt 2040 agagccagcc gaagaggagg cggaggagga agaggaggag gaagaggcgg aggaggagga 2100 ggaagaagag gaggaggaag aagaggagga ggaagacgag ggttgcaaag gactctttcc 2160 aagcgagttg gatgaggaac tggaggacag gccccatgag gagcctgggg ccgcagcagg 2220 tagtagcagc aaaaaggacc ttgctctctc aaaccaaagc atttctaact cccccttaat 2280 gcctaacgtg ctccagaccc tgtcgagggg cacagcttct actagttcta attctgcttc 2340 ttcctttgtt gtctttgatg gtgcgaacag gaggaatcgt ttaagcttta acagtgaggg 2400 cgtcaggacc aatgtggcag agggcggcag gaggctggac ttcgctgacg aaagtgccaa 2460 taaagacaat gccacagcac cagaaccaaa tgaaagtaca gagggtgacg atgggggctt 2520 cgttccccat caccagcacg ctggctccct ctgcgagctt ggggttgggg agtgcccctc 2580 ggggagtggc gtggagtgcc ccaaatgcga cacggtcctg ggctcctccc gctcgctggg 2640 cggccacatg accatgatgc attctcgtaa ctcgtgtaag acactcaagt gccccaagtg 2700 caactggcac tataagtacc agcagaccct ggaggcacac atgaaggaga agcacccgga 2760 gccggggggc tcctgtgtct actgcaaaag cgggcagccc cacccccggc tggcacgagg 2820 cgagagctac acgtgtggtt acaagccttt ccgctgcgag gtgtgtaact actccacaac 2880 taccaaaggc aacctcagta ttcatatgca gtctgacaag catctcaaca acatgcagaa 2940 cctacagaat ggaggggggg agcaggtctt catccacact gccggggcgg cggcggcggc 3000 ggcggctgcg gcggcggcgg cagccaatat cagtagctcc tgcggggccc cctcgcccac 3060 caaaccaaaa accaaaccca cctggcggtg cgaggtgtgt gattatgaga ccaacgtggc 3120 caggaacctc cgcattcaca tgaccagtga gaagcacatg cataacatga tgttactgca 3180 acagaacatg acccagatcc aacacaacca ccaccgggtc ctcggcagcc tgccctcacc 3240 cgccgaggcc gagctctacc aatactacct ggcccagaac atgaacctgc ccaacctgaa 3300 gatggacagt gctgcctcgg acgcccagtt catgatgagc ggattccagc tggatcccgc 3360 cgggcccatg gccgccatga cgcctgctct agtgggcggt gagatccccc tagacatgcg 3420 gctcgggggc gggcagctgg tgtcagagga gctgatgaac ctgggcgaga gcttcatcca 3480 gaccaacgac ccgtcgctga agctcttcca gtgcgccgtc tgcaacaagt tcacgacgga 3540 caacctggac atgctgggcc tgcacatgaa cgtggagcgc agcctgtcgg aggacgagtg 3600 gaaggcggtg atgggggact cataccagtg caagctctgc cgctacaaca cccagctcaa 3660 ggccaacttc cagctgcact gcaagacaga caagcacgtg cagaagtacc agctggtggc 3720 ccacatcaag gagggcggca aggccaacga gtggaggctc aagtgtgtgg ccatcggcaa 3780 ccccgtgcac ctcaagtgca acgcctgtga ctactacacc aacagcctgg agaagctgcg 3840 gctgcacacg gtcaactcca ggcacgaggc cagcctgaag ttgtacaagc acctgcagca 3900 gcatgagagt ggtgtagaag gtgagagctg ctactaccac tgcgttctgt gcaactactc 3960 caccaaggcc aagctcaacc tcatccagca tgtgcgctcc atgaagcacc agcgaagcga 4020 gagcctgcga aagctgcagc ggctgcagaa gggccttcca gaggaggacg aggacctggg 4080 gcagatcttc accatccgca ggtgcccctc cacggaccca gaagaagcca ttgaagatgt 4140 tgaaggaccc agtgaaacag ctgctgatcc agaggagctt gctaaggacc aagagggcgg 4200 agcatcgtcc agccaagcag agaaggagct gacagattct cctgcaacct ccaaacgcat 4260 ctccttccca ggtagctcag agtctcccct ctcttcgaag cgaccaaaaa cagctgagga 4320 gatcaaaccg gagcagatgt accagtgtcc ctactgcaag tacagtaatg ccgatgtcaa 4380 ccggctccgg gtgcatgcca tgacgcagca ctcggtgcaa cccatgcttc gctgccccct 4440 gtgccaggac atgctcaaca acaagatcca cctccagctg cacctcaccc acctccacag 4500 cgtggcacct gactgcgtgg agaagctcat tatgacggtg accacccctg agatggtgat 4560 gccaagcagc atgttcctcc cagcagctgt tccagatcga gatgggaatt ccaatttgga 4620 agaggcagga aagcagcctg aaacctcaga ggatctggga aagaacatct tgccatccgc 4680 aagcacagag caaagcggag atttgaaacc atcccctgct gacccaggct ctgtgagaga 4740 agactcaggc ttcatctgct ggaagaaggg gtgcaaccag gttttcaaaa cttctgctgc 4800 ccttcagacg cattttaatg aagtgcatgc caagaggcct cagctgccgg tgtcagatcg 4860 ccatgtgtac aagtaccgct gtaatcagtg tagcctggcc ttcaagacca ttgaaaagtt 4920 gcagctccat tctcagtacc atgtgatcag agctgccacc atgtgctgtc tttgtcagcg 4980 cagtttccga actttccagg ctctgaagaa gcaccttgag acaagccacc tggagctgag 5040 tgaggctgac atccaacagc tttatggtgg cctgctggcc aatggggacc tcctggcaat 5100 gggagacccc actctggctg aggaccatac cataattgtt gaggaagaca aggaggaaga 5160 gagtgacttg gaagataaac agagcccaac gggcagtgac tctgggtcag tacaagaaga 5220 ctcgggctca gagccaaaga gagctctgcc tttcagaaaa ggtcccaatt ttactatgga 5280 aaagttccta gacccttctc gcccttacaa gtgtaccgtc tgcaaggaat ctttcactca 5340 aaagaatatc ctgctagtac actacaattc tgtctcccac ctgcataagt taaagagagc 5400 ccttcaagaa tcagcaaccg gtcagccaga acccaccagc agcccagaca acaaaccttt 5460 taagtgtaac acttgtaatg tggcctacag ccagagttcc actctggaga tccatatgag 5520 gtctgtgtta catcaaacca aggcccgggc agccaagctg gaggctgcaa gtggcagcag 5580 caatgggact gggaacagca gcagtatttc cttgagctcc tccacgccaa gtcctgtgag 5640 caccagtggc agtaacacct ttaccacctc caatccaagc agtgctggca ttgctccaag 5700 ctctaactta ctaagccaag tgcccactga gagtgtaggg atgccacccc tggggaatcc 5760 tattggtgcc aacattgctt ccccttcaga gcccaaagag gccaatcgga agaaactggc 5820 agatatgatt gcatccaggc agcagcaaca acagcagcag caacagcaac aacaacaaca 5880 acaacaacaa caacaagcac aaacgctggc ccaggcccag gctcaagttc aagctcacct 5940 gcagcaggag ctgcagcaac aggctgccct gatccagtct cagctgttta accccaccct 6000 ccttcctcac ttccccatga caactgagac cctgctgcaa ctacagcagc agcagcacct 6060 cctcttccct ttctacatcc ccagtgctga gttccagctt aaccccgagg tgagcttgcc 6120 agtgaccagt ggggcactga cactgactgg gacaggccca ggcctgctgg aagatctgaa 6180 ggctcaggtt caggtcccac agcagagcca tcagcagatc ttgccgcagc agcagcagaa 6240 ccaactctct atagcccaga gtcactctgc cctccttcag ccaagccagc accccgaaaa 6300 gaagaacaaa ttggtcatca aagaaaagga aaaagaaagc cagagagaga gggacagcgc 6360 cgagggggga gagggcaaca ccggtccgaa ggaaacactg ccagatgcct tgaaggccaa 6420 agagaagaaa gagttggcac cagggggtgg ttctgagcct tccatgctcc ctccacgcat 6480 tgcttcagat gccagaggga acgccaccaa ggccctgctg gagaactttg gctttgagtt 6540 ggtcatccag tataatgaga acaagcagaa ggtgcagaaa aagaatggga agactgacca 6600 gggagagaac ctggaaaagc tcgagtgtga ctcctgcggc aagttgtttt ccaacatctt 6660 gattttaaag agtcatcaag agcacgttca tcagaattac tttcctttca aacagctcga 6720 gaggtttgcc aaacagtaca gagaccacta cgataaactg tacccactga ggccccagac 6780 cccagagcca ccaccacctc cccctccacc ccctccaccc ccacttccgg cagcgccgcc 6840 tcagccggcg tccacaccag ccatccccgc atcagcccca cccatcacct cacctacaat 6900 tgcaccggcc cagccatcag tgccgctcac ccagctctcc atgccgatgg agctgcccat 6960 cttctcgccg ctgatgatgc agacgatgcc gctgcagacc ttgccggctc agctaccccc 7020 gcagctggga cctgtggagc ctctgcctgc ggacctggcc caactctacc agcatcagct 7080 caatccaacc ctgctccagc agcagaacaa gaggcctcgc accaggatca cagatgatca 7140 gctccgagtc ttgcggcaat attttgacat taacaactcc cccagtgaag agcaaataaa 7200 agagatggca gacaagtccg ggttgcccca gaaagtgatc aagcactggt tcaggaacac 7260 tctcttcaaa gagaggcagc gtaacaagga ctccccttac aacttcagta atcctcctat 7320 caccagcctg gaggagctca agattgactc ccggccccct tcgccggaac ctccaaagca 7380 ggagtactgg ggaagcaaga ggtcttcaag aacaaggttt acggactacc agctgagggt 7440 cttacaggac ttcttcgatg ccaatgctta cccaaaggat gatgaatttg agcaactctc 7500 taatttactg aaccttccaa cccgagtgat agtggtgtgg tttcagaatg cccgacagaa 7560 ggccaggaag aattatgaga atcagggaga gggcaaagat ggagagcggc gtgagcttac 7620 aaatgataga tacattcgaa caagcaactt gaactaccag tgcaaaaaat gtagcctggt 7680 gtttcagcgc atctttgatc tcatcaagca ccagaagaag ctgtgttaca aggatgagga 7740 tgaggagggg caggacgaca gccaaaatga ggattccatg gatgccatgg aaatcctgac 7800 gcctaccagc tcatcctgca gtaccccgat gccctcacag gcttacagcg ccccagcacc 7860 atcagccaat aatacagctt cctccgcttt cttgcagctt acagcggagg ctgaggaact 7920 ggccaccttc aattcaaaaa cagaggcagg cgatgagaaa ccaaagctgg cggaagctcc 7980 cagtgcacag ccaaaccaaa cccaagaaaa gcaaggacaa ccaaagccag agctgcagca 8040 gcaagagcag cccgagcaga agaccaacac tccccagcag aagctccccc agctggtgtc 8100 cctgccttcg ttgccacagc ctcctccaca agcgccccct ccacagtgcc ccttacccca 8160 gtcgagcccc agtccttccc agctctccca cctgcccctc aagcccctcc acacatcaac 8220 tcctcaacag ctcgcaaacc tacctcctca gctaatcccc taccagtgtg accagtgtaa 8280 gttggcattt ccgtcatttg agcactggca ggagcatcag cagctccact tcctgagcgc 8340 gcagaaccag ttcatccacc cccagttttt ggacaggtcc ctggatatgc ctttcatgct 8400 ctttgatccc agtaacccac tcctggccag ccagctgctc tctggggcca tacctcagat 8460 tccagcaagc tcagccactt ctccttcaac tccaacctcc acaatgaaca ctctcaagag 8520 gaagctggag gaaaaggcca gtgcaagccc tggcgaaaac gacagtggga caggaggaga 8580 agagcctcag agagacaagc gtttgagaac aaccatcaca ccggaacaac tagaaattct 8640 ctaccagaag tatctactgg attccaatcc gactcgaaag atgttggatc acattgcaca 8700 cgaggtgggc ttgaagaaac gtgtggtaca agtctggttt cagaacaccc gagctcggga 8760 aaggaaagga cagttccggg ctgtaggccc agcgcaggcc cacaggagat gccctttttg 8820 cagagcgctc ttcaaagcca agactgctct tgaggctcat atccggtccc gtcactggca 8880 tgaagccaag agagctggct acaacctaac tctgtctgcg atgctcttag actgtgatgg 8940 gggactccag atgaaaggag atatttttga cggaactagc ttttcccacc tacccccaag 9000 cagtagtgat ggtcagggtg tccccctctc acctgtgagt aaaaccatgg aattgtcacc 9060 cagaactctt ctaagccctt cctccattaa ggtggaaggg attgaagact ttgaaagccc 9120 ctccatgtcc tcagttaatc taaactttga ccaaactaag ctggacaacg atgactgttc 9180 ctctgtcaac acagcaatca cagataccac aactggagac gagggcaacg cagataacga 9240 cagtgcaacg ggaatagcaa ctgaaaccaa atcctcttct gcacccaacg aagggttgac 9300 caaagcggcc atgatggcaa tgtctgagta tgaagatcgg ttgtcatctg gtctggtcag 9360 cccggccccg agcttttata gcaaggaata tgacaatgaa ggtacagtgg actacagtga 9420 aacctcaagc cttgcagatc cctgctcccc gagtcctggt gcgagtggat ctgcaggcaa 9480 atctggtgac agcggagatc ggcctgggca gaaacgtttt cgcactcaaa tgaccaatct 9540 gcagctgaag gtcctcaagt catgctttaa tgactacagg acacccacta tgctagaatg 9600 tgaggtcctg ggcaatgaca ttggactgcc aaagagagtc gttcaggtct ggttccagaa 9660 tgcccgggca aaagaaaaga agtccaagtt aagcatggcc aagcattttg gtataaacca 9720 aacgagttat gagggaccca aaacagagtg cactttgtgt ggcatcaagt acagcgctcg 9780 gctgtctgta cgtgaccata tcttttccca acagcatatc tccaaagtta aagacaccat 9840 tggaagccag ctggacaagg agaaagaata ctttgaccca gccaccgtac gtcagttgat 9900 ggctcaacaa gagttggacc ggattaaaaa ggccaacgag gtccttggac tggcagctca 9960 gcagcaaggg atgtttgaca acacccctct tcaggccctt aaccttccta cagcatatcc 10020 agcgctccag ggcattcctc ctgtgttgct cccgggcctc aacagcccct ccttgccagg 10080 ctttactcca tccaacacag ctttaacgtc tcctaagccg aacttgatgg gtctgcccag 10140 cacaactgtt ccttcccctg gcctccccac ttctggatta ccaaataaac cgtcctcagc 10200 gtcgctgagc tccccaaccc cagcacaagc cacgatggcg atgggccctc agcaaccccc 10260 ccagcagcag cagcagcagc agcaaccaca ggtgcagcag cctcccccgc cgccagcagc 10320 ccagccgcca cccacaccac agctcccact gcaacagcag cagcaacgca aggacaaaga 10380 cagtgagaaa gtaaaggaga aggaaaaggc acacaaaggg aaaggggaac ccctgcctgt 10440 ccccaagaag gagaaaggag aggcccccac ggcaactgca gccacgatct cagccccgct 10500 gcccaccatg gagtatgcgg tagaccctgc acagctgcag gccctgcagg ccgcgttgac 10560 ttcggacccc acagcattgc tcacaagcca gttccttcct tactttgtac caggcttttc 10620 tccttattat gctccccaga tccctggcgc cctgcagagc gggtacctgc agcctatgta 10680 tggcatggaa ggcctgttcc cctacagccc tgcactgtcg caggccctga tggggctgtc 10740 cccaggctcc ctactgcagc agtaccagca ataccagcag agtctgcagg aggcaattca 10800 gcagcagcag cagcggcaac tacagcagca gcagcagcaa aaagtgcagc agcagcagcc 10860 caaagcaagc caaaccccag tcccccccgg ggctccttcc ccagacaaag accctgccaa 10920 agaatccccc aaaccagaag aacagaaaaa caccccccgt gaggtgtccc ccctcctgcc 10980 gaaactccct gaagagccag aagcagaaag caaaagtgcg gactccctct acgacccctt 11040 cattgttcca aaggtgcagt acaagttggt ctgccgcaag tgccaggcgg gcttcagcga 11100 cgaggaggca gcgaggagcc acctgaagtc cctctgcttc ttcggccagt ctgtggtgaa 11160 cctgcaagag atggtgcttc acgtccccac cggcggcggc ggcggtggca gtggcggcgg 11220 cggcggcggt ggcggcggcg gcggcggcgg cggctcgtac cactgcctgg cgtgcgagag 11280 cgcgctctgt ggggaggaag ctctgagtca acatctcgag tcggccttgc acaaacacag 11340 aacaatcacg agagcagcaa gaaacgccaa agagcaccct agtttattac ctcactctgc 11400 ctgcttcccc gatcctagca ccgcatctac ctcgcagtct gccgctcact caaacgacag 11460 cccccctccc ccgtcggccg ccgccccctc ctccgcttcc ccccacgcct ccaggaagtc 11520 ttggccgcaa gtggtctccc gggcttcggc agcgaagccc ccttcttttc ctcctctctc 11580 ctcatcttca acggttacct caagttcatg cagcacctca ggggttcagc cctcgatgcc 11640 aacagacgac tattcggagg agtctgacac ggatctcagc caaaagtccg acggaccggc 11700 gagcccggtg gagggtccca aagaccccag ctgccccaag gacagtggtc tgaccagtgt 11760 aggaacggac accttcagat tgtaagcttt gaagatgaac aatacaaaca aatgaattta 11820 aatacaaaaa ttaataacaa accaatttca aaaatagact aactgcaatt ccaaagcttc 11880 taaccaaaaa aca 11893 <210> 149 <211> 3594 <212> DNA <213> Homo sapiens <400> 149 gtggctcacc tgtacccagc acttgggaag ccgaggcgtg cagatcacct aagtcaggag 60 ttcgagacca gcccggccaa catggtgaaa ccccgtctct actaaaaata caaaaatcag 120 ccagatgtgg cacgcaccta tatccaccta ctcgggaggc tgaagcagaa tgcttaaccc 180 gagaggcgga ggttgcagtg agccgcccag atcgcgccac tgcactccag cctgggccac 240 agcgtgagac tactcataaa ataaaataaa ataaaataaa ataaaataaa ataaaataaa 300 ataataaaat aaaataaaat aaaataaaat ataaaataaa ataaaataaa ataaaataaa 360 ataaaataaa ataaaagcaa tttcctttcc tctaagcggc ctccacccct ctcccctgcc 420 ctgtgaacgg gggaagctcc ggatcgcagc aattagggaa tttccccccg cgatgtcccg 480 gcgcgccagt tcggcgcaca tctttcgctg cggtcctctt cctgctgtct gtttactccc 540 taggcccctg gacctgggaa agagggaaag gcttcccgcc agctgcgcgg cgactccggg 600 gactccaggg cgcccctctg cggcgacgcc cgggtgcagc ggccgccggg ctggggccgg 660 cgggactccg cgggaccctc cagaagagcg gccggcggct gactcagcac tggggcggag 720 gggcgggaca cccttataag gctcggagcg cgagccttcg ctggagtttc gccgccgcag 780 tcttcgccac cagtgagtac gcggccgcgt ccccggggat ggggctcaga gctccagcat 840 ggggccaacc cgcagcatca ggccgggctc ccggcggcct ccccacctcg agacccggga 900 cggggcctag gggacccagg acgtcccagt gccgttagcg gctttcaggg ggcccggagc 960 gcctcgggga gggatgggac cccgggggcg ggagggcagc tcactcaccg cgccttggca 1020 tcctccccgg gctccacaaa ttttctttgt tcgctgcagt gccgccctac accgtggtct 1080 atttcccagt tcgaggtagg agcatgtgtc tggcagggaa gggaggcagg ggctggggct 1140 gcagcaccca cagcccccac ccggagagat ccgaaccccc ttatccctcg tcgtgtgctt 1200 ttacccccgg cctccttcct gttccccgcc tctcccgcca tgcctgctcc ccgccccagt 1260 gttgtgtgaa atcttcggag gaacctgttt ccctgttccc tccctgcact cctgacccct 1320 ccccgggttg ctgcgaggcg gagtcggccc ggtccccaca tctcgtactt ctccctcccc 1380 gcaggccgct gcgcggccct gcgcatgctg ctggcagatc agggccagag ctggaaggag 1440 gaggtggtga ccgtggagac gtggcaggag ggctcactca aagcctcctg cgtaagtgac 1500 catgcccggg caaggggagg gggtgctggg ccttaggggg ctgtgactag gatcggggga 1560 cgccccaagc tcagtgcccc tccctgagcc atgcctcccc caacagctat acgggcagct 1620 ccccaagttc caggacggag acctcaccct gtaccagtcc aataccatcc tgcgtcacct 1680 gggccgcacc cttggtgagt cttgaacctc caagtccagg gcaggcatgg gcaagcctct 1740 gcccccggag cccttttgtt taaatcagct gccccgcagc cctctggagt ggaggaaact 1800 gagacccact gaggttacgt agtttgccca aggtcaagcc tgggtgcctg caatccttgc 1860 cctgtgccag gctgcctccc aggtgtcagg tgagctctga gcacctgctg tgtggcagtc 1920 tctcatcctt ccacgcacat cctcttcccc tcctcccagg ctggggctca cagacagccc 1980 cctggttggc ccatccccag tgactgtgtt gatcaggcgc ccagtcacgc ggcctgctcc 2040 cctccaccca accccagggc tctatgggaa ggaccagcag gaggcagccc tggtggacat 2100 ggtgaatgac ggcgtggagg acctccgctg caaatacatc tccctcatct acaccaacta 2160 tgtgagcatc tgcaccaggg ttgggcactg ggggctgaac aaagaaaggg gcttcttgtg 2220 ccctcacccc ccttacccct caggtggctt gggctgaccc cttcttgggt cagggtgcag 2280 gggctgggtc agctctgggc caggggggcc tgggacaaga cacaacctgc acccttattg 2340 cctgggacat caaccaccca agtaacgggt catgggggcg agtgcaagga cagagacctc 2400 cagcaactgg tggtttctgc tctcctgggg tggccagagg tggaggagga tttgtgccag 2460 tttctggatg gagccgctgg cgcttttagc tgaggaaaat atgagacaca gagcactttg 2520 ggtaccaggg accagttcag cagaggcagc gtgtgtggcg tgtgtgtgcg tgtgtgtgcg 2580 tgtgtgtgtg tacgcttgca tttgtgtcgg gtgggtaagg agatagagat ggggcggcag 2640 taggcccagg tcccgaaggc cttgaaccca ctggtttgga gtctcctaag ggcaatgggg 2700 gccattgaga agtctgaaca gggctgtgtc tgaatgtgag gtctagaagg atcctccaga 2760 gaagccagct ctaaagcttt tgcaatcatc tggtgagaga acccagcaag gatggacagg 2820 cagaatggaa tagagatgag ttggcagctg aagtggacag gatttggtac tagcctggtt 2880 gtggggagca agcagaggag aatctgggac tctggtgtct ggcctggggc agacgggggt 2940 gtctcagggg ctgggaggga tgagagtagg atgatacatg gtgtgtgctg gcaggaggcg 3000 ggcaaggatg actatgtgaa ggcactgccc gggcaactga agccttttga gaccctgctg 3060 tcccagaacc agggaggcaa gaccttcatt gtgggagacc aggtgagcat ctggccccat 3120 gctgttcctt cctcgccacc ctctgcttcc agatggacac aggtgtgagc catttgttta 3180 gcaaagcaga gcagacctag gggatgggct taggccctct gcccccaatt cctctccagc 3240 ctgctcccgc tggctgagtc cctagccccc ctgccctgca gatctccttc gctgactaca 3300 acctgctgga cttgctgctg atccatgagg tcctagcccc tggctgcctg gatgcgttcc 3360 ccctgctctc agcatatgtg gggcgcctca gtgcccggcc caagctcaag gccttcctgg 3420 cctcccctga gtacgtgaac ctccccatca atggcaacgg gaaacagtga gggttggggg 3480 gactctgagc gggaggcaga gtttgccttc ctttctccag gaccaataaa agggctaaga 3540 gagctactat gagcactgtg tttcctggga cggggcttag gggttctcag cctc 3594 <210> 150 <211> 1799 <212> DNA <213> Homo sapiens <400> 150 cctctctgtg ctgggttcct ccagtgtaga ggagaggcag gtacagcctg tcctcctggg 60 gacatggcat gagggccgcg tcctcacagc gcattctgtg ttccagcatc cccgaccagc 120 cccaaggtct tcccgctgag cctcgacagc accccccaag atgggaacgt ggtcgtcgca 180 tgcctggtcc agggcttctt cccccaggag ccactcagtg tgacctggag cgaaagcgga 240 cagaacgtga ccgccagaaa cttcccacct agccaggatg cctccgggga cctgtacacc 300 acgagcagcc agctgaccct gccggccaca cagtgcccag acggcaagtc cgtgacatgc 360 cacgtgaagc actacacgaa ttccagccag gatgtgactg tgccctgccg aggtcagagg 420 gcaggctggg gagtggggcg gggccacccc gtcctgccct gacactgcgc ctgcacccgt 480 gttccccaca gggagccgcc ccttcactca caccagagtg gaccgcgggc cgagccccag 540 gaggtggtgg tggacaggcc aggaggggcg aggcgggggc acggggaagg gcgttctgac 600 cagctcaggc catctctcca ctccagttcc cccacctccc ccatgctgcc acccccgact 660 gtcgctgcac cgaccggccc tcgaggacct gctcttaggt tcagaagcga acctcacgtg 720 cacactgacc ggcctgagag atgcctctgg tgccaccttc acctggacgc cctcaagtgg 780 gaagagcgct gttcaaggac cacctgagcg tgacctctgt ggctgctaca gcgtgtccag 840 tgtcctgcct ggctgtgccc agccatggaa ccatggggag accttcacct gcactgctgc 900 ccaccccgag ttgaagaccc cactaaccgc caacatcaca aaatccggtg ggtccagacc 960 ctgctcgggg ccctgctcag tgctctggtt tgcaaagcat attcccggcc tgcctcctcc 1020 ctcccaatcc tgggctccag tgctcatgcc aagtacagag ggaaactgag gcaggctgag 1080 gggccaggac acagcccagg gtgcccacca gagcagaggg gctctctcat cccctgccca 1140 gccccctgac ctggctctct accctccagg aaacacattc cggcccgagg tccacctgct 1200 gccgccgccg tcggaggagc tggccctgaa cgagctggtg acgctgacgt gcctggcacg 1260 tggcttcagc cccaaggatg tgctggttcg ctggctgcag gggtcacagg agctgccccg 1320 cgagaagtac ctgacttggg catcccggca ggagcccagc cagggcacca ccaccttcgc 1380 tgtgaccagc atactgcgcg tggcagccga ggactggaag aagggggaca ccttctcctg 1440 catggtgggc cacgaggccc tgccgctggc cttcacacag aagaccatcg accgcttggc 1500 gggtaaaccc acccatgtca atgtgtctgt tgtcatggcg gaggtggacg gcacctgcta 1560 ctgagccgcc cgcctgtccc cacccctgaa taaactccat gctcccccaa gcagccccac 1620 gcttccatcc ggcgcctgtc tgtccatcct cagggtctca gcacttggga aagggccagg 1680 gcatggacag ggaagaatac cccctgccct gagcctcggg gggcccctgg cacccccatg 1740 agactttcca ccctggtgtg agtgtgagtt gtgagtgtga gagtgtgtgg tgcaggagg 1799 <210> 151 <211> 945 <212> DNA <213> Homo sapiens <400> 151 ctgggtgtac agcgtcctcg aaaccacgag caagtgagca gatcctccga ggcaccaggg 60 actccagccc atgccatggc ggattctgag cgcctctcgg ctcctggctg ctgggccgcc 120 tgcaccaact tctcgcgcac tcgaaaggga atcctcctgt ttgctgagat tatattatgc 180 ctggtgatcc tgatctgctt cagtgcctcc acaccaggct actcctccct gtcggtgatt 240 gagatgatcc ttgctgctat tttctttgtt gtctacatgt gtgacctgca caccaagata 300 ccattcatca actggccctg gagtgatttc ttccgaaccc tcatagcggc aatcctctac 360 ctgatcacct ccattgttgt ccttgttgag agaggaaacc actccaaaat cgtcgcaggg 420 gtactgggcc taatcgctac gtgcctcttt ggctatgacg cctatgtcac cttccccgtt 480 cggcagccaa gacatacagc agcccccact gaccccgcag atggcccggt gtaggcgaac 540 ttccctcatt tctctctgca atctgcaaat aactcctcca ttgaaataac tcctccccac 600 cccaacaaca acattcccag cagaccaact cccaccccct ctttgaggta aaagtgcctt 660 tattgggaga cttttgtctt ccagcctgcc aatcaaccct cctgggtgtg gccaccatat 720 gtgtgtgcct aggtcctcct tctgcacgat ccaataggag acaccagttc tgactgaacc 780 atgcccccac ctaagtcaca aaatgaggga agtggggagt tagatttcag agtccaggcc 840 ctaggttggg acccactcca aataatctcc tcggtgtggg tggtggttct atagagggat 900 aaatgaataa taaacattgt taaaatataa aaaaaaaaaa aaaaa 945 <210> 152 <211> 347 <212> DNA <213> Homo sapiens <400> 152 ctgttgtttg ttcaccttta tttgtgaagt gctatgccct tggtttttcc acttagttat 60 taacatgaat tagcaagtca aaaaacattt actaacccac aaatacaaaa catttactag 120 ggtttccagt acttatttga atgaattatt agtttaggag gttaaagatg gtaggaaaag 180 tgtgtaatct gcgtgtcttc tgtataccna ataataaaat atgtngtgaa tctggtttta 240 ggtctagcac actgtttttt ttttaaagca gaaatagggg gtttatttga tactagaact 300 aaagaaataa ggnagtttga tgccaaaaca nnttgttaat tcttttt 347 <210> 153 <211> 1404 <212> DNA <213> Homo sapiens <400> 153 aaatcgacag ttttattctt agactcatgt gatccaagct gtatatacca tatataaaca 60 ttttacatga atcatttagt tttttaattc atttactaat gctataaaat ttcctatatt 120 accccagtaa tttgcatcag ctggtttata tactaaagca acatgttttg atgagtttct 180 tacatcctta tcgaggaatt gggttaggaa aaaatacata attgtaaaac tgagtttgct 240 gtattatact tttttcttga gtattagttg tattactaat catatgttga ttaactgtct 300 acttaaagtc aaggtacctg tatttttaat ccactaattt ttttttagtt gggaaataga 360 tttcaggtct tttattagac taacattttt tgagaagtaa aattgacttc atatacaaag 420 cctgtaattt taggcgaaat ggaagcagaa atctaggaag ttgtgcttgc ttgtatgttg 480 agtttggtct cagactaagt aatgcatcag aattcatctg tttgaagcct gaaataattt 540 aggactctga ttcactgacc aaaagtcagt gtttcagaga tttctctacc ccgtatggta 600 ttttgttaga ttgttcaaca ggaagcacat gattgagaac atcttgggac agaccaaaac 660 cactgacaga tggcaaggct cggcgattct gatttccctt ctcaaatctg ctcaactcca 720 agagtcttga gaaactgcta aaattttgcc tctgtcactc aagtcttaca aatgttatct 780 tgtaaacctt tgaggtgaac tattccactg tcttgtacat aggcatctta ttcactgcac 840 cctgtcacac ccagcacccc ccgccccgca cattatttga aagactggga atttaatggt 900 tagggacagt aaatctactt ctttttccag ggacgactgt cccctctaaa gttaaagtca 960 atacaagaaa actgtctatt tttagcctaa agtaaaggct gtgaagaaaa ttcattttac 1020 attgggtaga cagtaaaaaa caagtaaaat aacttgacat gagcaccttt agatcccttc 1080 ccctccatgg gctttgggcc acagaatgaa cctttgaggc ctgtaaagtg gattgtaatt 1140 tcctataagc tgtaatagtg gaggtattgt gggttcattt gagtaagccc tccaaagata 1200 ccattcaaat aacctgggag aatgtcataa attattcaga taattaacac tgcatgaatc 1260 tgattcagag gcatgcattt acatatgttg ccctaattac catttgatga tcataaatac 1320 aagtgaatga cattggactt ttagtaacaa acttaatttt taaaaaggtg tagacaatgg 1380 tggttaaaaa aaaaaaaaaa aaaa 1404 <210> 154 <211> 490 <212> DNA <213> Homo sapiens <400> 154 tttgagacga attaagagtc cgtttattta gcctgcggcc aagagatggc taatgctcaa 60 agttctcttg gccccgaaga aggggctaga ttttctttta tactttggtt tagaaagggg 120 agggggggtc tagttaaaac aattttacag aagtaaagta ggcaaaaaag ttaaaaggat 180 aaatggttac aggaaagtaa acagttccag gtgcaggggc tttaagacta ttacaagatg 240 atagacacga ggctttgggc gttatcaatc agacgaattc ctgggaactg cggatatagc 300 tcgccacagt atcttatcag ttaactgcat tcttggatgt gctgggagtc agcttgcaca 360 agttaagtcc ttgaggaagg ggctgccagg gaaagagcca agatggagtc tgtctggctc 420 tctcagctaa gggagagtcc attcaggtgg aaatgaggct aggtgagtaa aggaaaggga 480 gagtctaaga 490 <210> 155 <211> 736 <212> DNA <213> Homo sapiens <400> 155 taacaagcca aagttgtatt tttttaaaca ggaaaattat gtcaatataa aacagataaa 60 aagacaaaaa tcaaaacaca caacacagaa aagcacaaca ctcaagacca gtgcaaaccc 120 ttcccaaccc acttcccagg ttttaaaacc ttgattacag atccccaagg attagactgt 180 atcggagagg tcacagtatt gaatcagaaa aagaagacat gttttaaaag gtctgtacac 240 aggtagtggt gtgtggggtg ggggatgtac acttcatcac tccaacatca aaaaacatga 300 tgcaaaaagg atttcagcga tgaccacaga tttctagaac cctaccacgt atgctagccc 360 ccctccccat ccacttttaa aagttgcttt taaaaaggat aaaaagtgca cagacacttt 420 cgtaaggcac agacagattg tcacacaagt cgtttcatta gggactcgga taagacagcg 480 agacagttaa ataccgagaa atgccaggag gccgcatgtt ccgagccggt gccccctggc 540 cggactgggg caggcgcggg ccgaggcaat gggaggttat tggcctctgc ctcaactgga 600 cggactcacc ggggttctcc tggggccttg gcgaactgat ttccggggcc gaaagcagca 660 attagccaac ctcctcactg tgtctccctg gcangacctg agggtgattc accaaccggc 720 ggggcctctg ggggtt 736 <210> 156 <211> 798 <212> DNA <213> Homo sapiens <400> 156 actagaaata tttggctctt ttaatcagct attcatggtg taataaaata aatttaagtg 60 gcacctaatt taacatttaa aatagttcat taaaagataa tctacaaaac aatgttatgc 120 ctaattgtca aaataacacc tttttttttt caagaaagga gaaataaagg cataatcaaa 180 attatggcta acaacgtggg ttcattttga cacttacaga tgattctgta ggcatatcgg 240 caggcacgat gttgaaaacc aatccactag atttaaaatt aatggtaaga taaaaaagaa 300 aagatacaca tttcagaggt aatgtgtgaa attaaagaaa aatatccacc atatattaca 360 acagatcttt taatgactat ttttaacata nagattgctg ttttgggaaa catctattct 420 ttttgaacat ttcactaaat tttcaatgta ttaaataact gacagaaata agttcttgtg 480 ttctgtccaa attaaagggt cccatgaata cataacnccc tcccagcccc accaaagctc 540 aattttgcat gggtttcagc agaaaataga cagcccaaat ttaaacagaa attcatagca 600 taccaaaggt taccggaccc ctattgtttc atcatttgtt ttttaccaca agatcacaat 660 gacagactgc atgatcgaaa ggaaaatatt tgtgccaaac tgcataattg ttcttacctt 720 tattggggtt aaaaacttag aacacgcatg aacattttga aaacgactac ttataagtaa 780 ttcttctttt gttatcaa 798 <210> 157 <211> 194 <212> DNA <213> Homo sapiens <400> 157 ttctcattta gcaaagtttt tattcaaaag cttctcagca ccatctagtt atcagaaaga 60 atggatatca ccttttcctg cccacccaat ccccagtttc ttgataacaa cagcatgggt 120 gatctcagtt cccttggcaa acatttttgg cttctcctgt atcagcacat atcccgtcat 180 gtacatgcca gcgg 194 <210> 158 <211> 570 <212> DNA <213> Homo sapiens <400> 158 tttttttttt tttttttagg gataatgctt ttatattagt ttttctataa caagaaaaat 60 cagctttgag atttttatca tttttttcct tagaaaagaa taaaaaataa aggcacccgg 120 aacttccccc acaggcctga agaacaaagg tgtctcctag gtgcagctgg gtccttcctc 180 cctggctcag cccagcccca tcacctctgc ttcactcctg ccccaaggcc ccagcagcac 240 ccagggggct ctcccatcct gcctccactg ggcttgccca ttggaaaagt gcctgtgtcc 300 tgccagggcg tggcagggag ggactcttag cagagtgact gcccagcacc tggaggagca 360 gggtgggcca ggccaggcca gcagtcctga aggctcctgt ccccatagga tgggaaagga 420 ataaaagcca gcttttgtga gttccagagg gtggcaggca cctggccaca gagcatggat 480 acccttgtgt cttctccagg gaacggacgg acagatggac agggcagacg gcgagctgct 540 atggctgatt ctggctgggg caagagctgt 570 <210> 159 <211> 1629 <212> DNA <213> Homo sapiens <400> 159 gggccgcccc aagggctcct cccgacctcc cggcctgccg ctccggccac tgcgggatcc 60 agaaacatgt cgaccacact tctgtccgcc ttctacgatg tcgacttctt gtgcaagaca 120 gagaaatccc tggccaacct caacctgaac aacatgctgg acaagaaggc ggtggggacg 180 cctgtggccg ccgcccccag ctcgggcttc gcgccgggat tcctccgacg gcactcggcc 240 agcaacctgc atgcactcgc ccaccccgcg cccagccccg gcagctgctc gcccaagttc 300 ccgggcgccg ctaacggcag cagctgcggc agcgcggcgg ccggcggtcc gacctcctac 360 ggcaccctta aggagccgtc ggggggcggc ggcacagccc tgctcaacaa ggagaacaaa 420 ttccgggacc gctcgtttag cgagaacggc gatcgcagcc agcacctcct gcacctgcag 480 cagcagcaga aggggggcgg cggctcccag atcaactcca cgcgctacaa gaccgagctg 540 tgccggccct tcgaggagag cggcacgtgc aagtacggcg aaaagtgcca gttcgcgcat 600 ggcttccacg agctgcgcag cctgactcgc catccgaagt acaagaccga gctgtgccgc 660 acctttcata ccatcggctt ctgcccctat gggccgcgct gccacttcat ccacaacgcg 720 gacgagcggc ggcccgcgcc gtcggggggc gcctccgggg acctgcgtgc ctttggcacg 780 cgcgatgcgt tgcacctggg cttcccgcgg gagccgcggc ccaagttgca ccacagcctc 840 agcttctcgg gcttcccgtc gggccaccat cagcccccgg gcggcctcga gtcgccgctg 900 ctgctcgaca gccccacgtc gcgcacgccg ccgccgccct cctgctcttc ggcctcgtcc 960 tgctcctcct ccgcctcctc ctgttcctcg gcctccgcgg cctccacgcc ctcggggacc 1020 ccgacatgct gcgcctccgc ggcggccgcg ctgcgtctgc tgtacggcac cgggggcgcc 1080 gaggacctgc tggcgccggg ggccccgtgc gcggcctgct cgtcggcctc gtgcgccaac 1140 aacgccttcg ccttcggtcc ggagctcagc agcctcatca cgccgctcgc catccagacc 1200 cacaactttg ccgccgtggc cgccgccgcc tactaccgca gtcagcagca gcagcagcag 1260 cagggcctgg cgccccccgc gcagccgccg gcgccgccca gcgcgaccct ccccgccggg 1320 gccgccgcac ctccctcgcc gcccttcagc ttccagctgc cgcgccgcct gtccgactcg 1380 cccgtgttcg acgcgccccc cagccccccg gactcgctgt cggaccgcga cagctaccta 1440 agcggctccc tgagctccgg cagcctcagc ggctctgagt ctcccagcct cgaccctggc 1500 cgccgcctgc caatcttcag ccgcctctcc atctccgacg actgaggcaa gagggcgcca 1560 gtgaggagga agggaaggcg gttcagagat gttggaggac acccctcgcc atctcgccct 1620 tgctggggg 1629 <210> 160 <211> 1757 <212> DNA <213> Homo sapiens <400> 160 cagcatgaag gcactcctgg ccctgccgct gctgctgctt ctctccacgc ccccgtgtgc 60 cccccaggtc tccgggatcc gaggagatgc tctggagagg ttttgccttc agcaacccct 120 ggactgtgac gacatctatg cccagggcta ccagtcagac ggcgtgtacc tcatctaccc 180 ctcgggcccc agtgtgcctg tgcccgtctt ctgtgacatg accaccgagg gcgggaagtg 240 gacggttttc cagaagagat tcaatggctc agtaagtttc ttccgcggct ggaatgacta 300 caagctgggc ttcggccgtg ctgatggaga gtactggctg gggctgcaga acatgcacct 360 cctgacactg aagcagaagt atgagctgcg agtggacttg gaggactttg agaacaacac 420 ggcctatgcc aagtacgctg acttctccat ctccccgaac gcggtcagcg cagaggagga 480 tggctacacc ctctttgtgg caggctttga ggatggcggg gcaggtgact ccctgtccta 540 ccacagtggc cagaagttct ctaccttcga ccgggaccag gacctctttg tgcagaactg 600 cgcagctctc tcctcaggag ccttctggtt ccgcagctgc cactttgcca acctcaatgg 660 cttctaccta ggtggctccc acctctctta tgccaatggc atcaactggg cccagtggaa 720 gggcttctac tactccctca aacgcactga gatgaaaatc cgccgggcct gaagggctgg 780 ccccctcagg cacctttcct cccctggaca cccatggtct ccatgagtgc tccctctgct 840 gcccctgatg catgcttctg ctgattcccg agcaccaact ccttacaagg gggccttgtg 900 gctctcagcc atgccacatc cctgtcacac acccagggca tccattccta agccagaccc 960 ggctccccta cacctgaagt tacactgcca gcagttcccc aggcctcttc cgagaggcac 1020 atggttctag cctggacctg gctgggctcc atgagaatga gttgcctcca ccctgtccca 1080 acagctgaca gccaggagcc actctcccag ctgcaggcct ttgtggtgca tcttgtcctg 1140 cttcctcact gtggacccct gtctgggcca ccctagtgtg ctaagctgag cagtgcagtg 1200 tgaacagggc ccatggtgta ttctaggcca cagcccagca ctcctctggg ctgctctcaa 1260 accatgtccc atcttcagca tccctcccac caacttactc ccctgtggtg agtaccgtgg 1320 aaccccagcc cacctcacta tcatactcag cttcccctga tggcccatcc cagcccctga 1380 agctctatgc caagaacaca gctaccgcac accaccctga aacagccaca gccaaggtag 1440 gcatgcatat gaggtcttcc ccataccctc tgggtgttga gaggtttagc cacatgaggg 1500 agcagaggac aatctctgca gggctgggag tgggtaggga ctgaaggtct caataaacct 1560 tcagaacctg aatgaactgg cttcatacac acaaacatat ttgtttatcc cccaaatgta 1620 ggcacctggc tcctccttgc tcccctgctg atggtgtcct accccgaact ccaaaaatta 1680 cacctggagt caggtgcaga agggaacctt gtatttcaca ggcctcattt tgatggcaaa 1740 aagacagtgt aataata 1757 <210> 161 <211> 431 <212> DNA <213> Homo sapiens <400> 161 tttcaacttt tttttttttt tttttttagg ggttcagggg ctgcacttta ttaatcagtg 60 tgttaatttt tgacagtgat tggactagac cttttcaaat agagtctgag ggtatcagac 120 agtgaaaatg tgctgtaact aagtagcatg taaatcagtt gattgtaaaa cgtttcgctg 180 ggaacttatt ttagctatat tttacttcag acagattatg atacaataat ctacctgtgc 240 atcagttagt aggtgctgca gggtttctta ctatttacag aaacattttg tgcagtcttt 300 gttataaatt ttcagaagac tatactcttt actttgaagg tctatttttt aattatacct 360 catttagcta actagtattc taatacctgg tagaaaaaca gtgagccagc ctttaagcat 420 ctaacaaaat t 431 <210> 162 <211> 669 <212> DNA <213> Homo sapiens <400> 162 attttttttt ttttggcttt tcaaacgttt attctcattt aactatacta atgggtctaa 60 atactggttt tacatcctac gtgatataag tatatataca aagaaaaaaa caacattgga 120 atattacaca gcttgaaggt ttgcaaaggt tatttgtgtc ttagttattt ctgcacttaa 180 tgacacatca gacgcattga gtatatttca taagttgttg actagcaaag atacaatcat 240 tagtaaccca agtcttcaaa attcacacca aactttatga agtcattcag aaagagaaag 300 tcaatcctaa aattaaaatt ggcaactatg ataaatacct tcaaaaggat gtagatataa 360 tggagatgtt taaaagttta gtttcattaa ttgtaaaatt agcatgttat atttactcaa 420 tatagtgaag actaggtgat tcttacatgt attctactta tggtactgta ctggttttag 480 tgtgaattta catagaataa atttacttca ctttcatgtc atcgacatga atgacacaaa 540 agctacttca taatactact ttacaatagt tttcaacatt tccatatggt gcgacccctt 600 tgctctcatc aattttgggt gtcatgagaa ccataggtat cccgttggac atgatgtatt 660 gcgaagagc 669 <210> 163 <211> 3231 <212> DNA <213> Homo sapiens <400> 163 cgtgaaggca aagagaacac gctgcaaaag gcttccaaga atcctcgaca tggcaaggag 60 gagctcgttc cagtcgtgtc agataatatc cctgttcact tttgccgttg gagtcagtat 120 ctgcttagga ttcactgcac atcgaattaa gagagcagaa ggatgggagg aaggtcctcc 180 tacagtgcta tcagactccc cctggaccaa catctccgga tcttgcaagg gcaggtgctt 240 tgaacttcaa gaggctggac ctcctgattg tcgctgtgac aacttgtgta agagctatac 300 cagttgctgc catgactttg atgagctgtg tttgaagaca gcccgtggct gggagtgtac 360 taaggacaga tgtggagaag tcagaaatga agaaaatgcc tgtcactgct cagaggactg 420 cttggccagg ggagactgct gtaccaatta ccaagtggtt tgcaaaggag agtcgcattg 480 ggttgatgat gactgtgagg aaataaaggc cgcagaatgc cctgcagggt ttgttcgccc 540 tccattaatc atcttctccg tggatggctt ccgtgcatca tacatgaaga aaggcagcaa 600 agtcatgcct aatattgaaa aactaaggtc ttgtggcaca cactctccct acatgaggcc 660 ggtgtaccca actaaaacct ttcctaactt atacactttg gccactgggc tatatccaga 720 atcacatgga attgttggca attcaatgta tgatcctgta tttgatgcca cttttcatct 780 gcgagggcga gagaaattta atcatagatg gtggggaggt caaccgctat ggattacagc 840 caccaagcaa ggggtgaaag ctggaacatt cttttggtct gttgtcatcc ctcacgagcg 900 gagaatatta accatattgc ggtggctcac cctgccagat catgagaggc cttcggtcta 960 tgccttctat tctgagcaac ctgatttctc tggacacaaa tatggccctt tcggccctga 1020 ggagagtagt tatggctcac cttttactcc ggctaagaga cctaagagga aagttgcccc 1080 taagaggaga caggaaagac cagttgctcc tccaaagaaa agaagaagaa aaatacatag 1140 gatggatcat tatgctgcgg aaactcgtca ggacaaaatg acaaatcctc tgagggaaat 1200 cgacaaaatt gtggggcaat taatggatgg actgaaacaa ctaaaactgc gtcggtgtgt 1260 caacgtcatc tttgtcggag accatggaat ggaagatgtc acatgtgata gaactgagtt 1320 cttgagtaat tacctaacta atgtggatga tattacttta gtgcctggaa ctctaggaag 1380 aattcgatcc aaatttagca acaatgctaa atatgacccc aaagccatta ttgccaatct 1440 cacgtgtaaa aaaccagatc agcactttaa gccttacttg aaacagcacc ttcccaaacg 1500 tttgcactat gccaacaaca gaagaattga ggatatccat ttattggtgg aacgcagatg 1560 gcatgttgca aggaaacctt tggatgttta taagaaacca tcaggaaaat gctttttcca 1620 gggagaccac ggatttgata acaaggtcaa cagcatgcag actgtttttg taggttatgg 1680 cccaacattt aagtacaaga ctaaagtgcc tccatttgaa aacattgaac tttacaatgt 1740 tatgtgtgat ctcctgggat tgaagccagc tcctaataat gggacccatg gaagtttgaa 1800 tcatctcctg cgcactaata ccttcaggcc aaccatgcca gaggaagtta ccagacccaa 1860 ttatccaggg attatgtacc ttcagtctga ttttgacctg ggctgcactt gtgatgataa 1920 ggtagagcca aagaacaagt tggatgaact caacaaacgg cttcatacaa aagggtctac 1980 agaagagaga cacctcctct atgggcgacc tgcagtgctt tatcggacta gatatgatat 2040 cttatatcac actgactttg aaagtggtta tagtgaaata ttcctaatgc tactctggac 2100 atcatatact gtttccaaac aggctgaggt ttccagcgtt cctgaccatc tgaccagttg 2160 cgtccggcct gatgtccgtg tttctccgag tttcagtcag aactgtttgg cctacaaaaa 2220 tgataagcag atgtcctacg gattcctctt tcctccttat ctgagctctt caccagaggc 2280 taaatatgat gcattccttg taaccaatat ggttccaatg tatcctgctt tcaaacgggt 2340 ctggaattat ttccaaaggg tattggtgaa gaaatatgct tcggaaagaa atggagttaa 2400 cgtgataagt ggaccaatct tcgactatga ctatgatggc ttacatgaca cagaagacaa 2460 aataaaacag tacgtggaag gcagttccat tcctgttcca actcactact acagcatcat 2520 caccagctgt ctggatttca ctcagcctgc cgacaagtgt gacggccctc tctctgtgtc 2580 ctccttcatc ctgcctcacc ggcctgacaa cgaggagagc tgcaatagct cagaggacga 2640 atcaaaatgg gtagaagaac tcatgaagat gcacacagct agggtgcgtg acattgaaca 2700 tctcaccagc ctggacttct tccgaaagac cagccgcagc tacccagaaa tcctgacact 2760 caagacatac ctgcatacat atgagagcga gatttaactt tctgagcatc tgcagtacag 2820 tcttatcaac tggttgtata tttttatatt gtttttgtat ttattaattt gaaaccagga 2880 cattaaaaat gttagtattt taatcctgta ccaaatctga catattatgc ctgaatgact 2940 ccactgtttt tctctaatgc ttgatttagg tagccttgtg ttctgagtag agcttgtaat 3000 aaatactgca gcttgagaaa aagtggaagc ttctaaatgg tgctgcagat ttgatatttg 3060 cattgaggaa atattaattt tccaatgcac agttgccaca tttagtcctg tactgtatgg 3120 aaacactgat tttgtaaagt tgcctttatt tgctgttaac tgttaactat gacagatata 3180 tttaagcctt ataaaccaat cttaaacata ataaatcaca cattcagttt t 3231 <210> 164 <211> 3910 <212> DNA <213> Homo sapiens <400> 164 gtggcagaaa acctcatgac acaatctctc cgcctccctg tgttggtgga ggatgtctgc 60 agcagcattt aaattctggg agggcttggt tgtcagcagc agcaggagga ggcagagcac 120 agcatcgtcg ggaccagact cgtctcaggc cagttgcagc cttctcagcc aaacgccgac 180 caaggaaaac tcactaccat gagaattgca gtgatttgct tttgcctcct aggcatcacc 240 tgtgccatac cagttaaaca ggctgattct ggaagttctg aggaaaagca gctttacaac 300 aaatacccag atgctgtggc cacatggcta aaccctgacc catctcagaa gcagaatctc 360 ctagccccac agaatgctgt gtcctctgaa gaaaccaatg actttaaaca agagaccctt 420 ccaagtaagt ccaacgaaag ccatgaccac atggatgata tggatgatga agatgatgac 480 gaccatgtgg acagccagga ctccattgac tcgaacgact ctgatgatgt agatgacact 540 gatgattctc accagtctga tgagtctcac cattctgatg aatctgatga actggtcact 600 gattttccca cggacctgcc agcaaccgaa gttttcactc cagttgtccc cacagtagac 660 acatatgatg gccgaggtga tagtgtggtt tatggactga ggtcaaaatc taagaagttt 720 cgcagacctg acatccagta ccctgatgct acagacgagg acatcacctc acacatggaa 780 agcgaggagt tgaatggtgc atacaaggcc atccccgttg cccaggacct gaacgcgcct 840 tctgattggg acagccgtgg gaaggacagt tatgaaacga gtcagctgga tgaccagagt 900 gctgaaaccc acagccacaa gcagtccaga ttatataagc ggaaagctaa tgatgagagc 960 aatgagcatt ccgatgtgat tgatagtcag gaactttcca aagtcagccg tgaattccac 1020 agccatgaat ttcacagcca tgaagatatg ctggttgtag accccaaaag taaggaagaa 1080 gataaacacc tgaaatttcg tatttctcat gaattagata gtgcatcttc tgaggtcaat 1140 taaaaggaga aaaaatacaa tttctcactt tgcatttagt caaaagaaaa aatgctttat 1200 agcaaaatga aagagaacat gaaatgcttc tttctcagtt tattggttga atgtgtatct 1260 atttgagtct ggaaataact gatgtgtttg ataattagtt tagtttgtgg cttcatggaa 1320 actccctgta aactaaaagc ttcagggtta tgtctatgtt cattctatag aagaaatgca 1380 aactatcact gtattttaat atttgttatt ctctcatgaa tagaaattta tgtagacgca 1440 aacaaaatac ttttacccac ttaaaaagag aatataacat tttatgtcac tataatcttt 1500 tgttttttaa gttagtgtat attttgttgt gattatcttt ttttacattc aagataaaag 1560 atttattcac accacaaaaa agataatcac aacaaaatat acactaactt aaaaaacaaa 1620 agattatagt gacataaaat gttatattct ctttttaagt gggtaaaagt attttgtttg 1680 cgtctacata aatttctatt catgagagaa taacaaatat taaaatacag tgatagtttg 1740 catttcttct atagaatgaa catagacata accctgaagc ttttagttta cagggagttt 1800 ccatgaagcc acaaactaaa ctaattatca aacacattag ttatttccag actcaaatag 1860 atacacattc aaccaataaa ctgagaaaga agcatttcat gttctctttc attttgctat 1920 aaagcatttt ttcttttgac taaatgcaaa gtgagaaatt gtattttttc tccttttaat 1980 tgacctcaga agatgcacta tctaattcat gagaaatacg aaatttcagg tgtttatctt 2040 cttccttact tttggggtct acaaccagca tatcttcatg gctgtgaaat tcatggctgt 2100 ggaattcacg gctgactttg gaaagttcct gactatcaat cacatcggaa tgctcattgc 2160 tctcatcatt ggctttccgc ttatataatc tggactgctt gtggctgtgg gtttcagcac 2220 tctggtcatc cagctgactc gtttcataac tgtccttccc acggctgtcc caatcagaag 2280 gcgcgttcag gtcctgggca acggggatgg ccttgtatgc accattcaac tcctcgcttt 2340 ccatgtgtga ggtgatgtcc tcgtctgtag catcagggta ctgaatcacg gcacaaatga 2400 agaataatta tatgaacggc tagggatggg aatatggtaa tccttttcca ctctctagct 2460 tttaggtcat cttatactaa aaattgtcta aatctggctg aaataatact agcatgttac 2520 tttgtatagt actttaccaa ggcctttcac atatgtcatc tcatttagtt taataactac 2580 atcacttaca tatgtaatga aacctatgag gtaggtttca ttatattgaa acctacataa 2640 agaggaagtg aattgttagt taaaaagtaa agagaatagt aaacggcaag gctatgtcaa 2700 atccagattc tgtgactaag gattcagtgt aatttgcaac tacaattcct cttaggtatt 2760 taacttcaaa acatgaccat tatttttttt aaataattgg tgttttccat ttattttaat 2820 ctgaaaataa gtgatccagg atttcaaaaa gtagaattgt gtttgagaat caaatctaga 2880 gagaaattat gtagacttac aaaaaccgcc aagaagaaaa agatttgtat tcaatggtca 2940 taaagtagaa tatgaatgaa ttcttgcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000 nnnnatgcaa actgtggttt cctagacttg agcgctagtc agaaccatca ggtgtgtctg 3060 ttaaaggatt tacctggatg tcaggtctgc gaaacttctt agatttgacc tcagtccata 3120 aaccacacta tcaccttggc catcatatgt gtctactgtg gggacaactg gagtgaaaac 3180 ttcggttgct ggcaggtccg tgggaaaatc agtgaccagt tcatcagatt catcagaatg 3240 gtgagactca tcagactggt gagaatcatc agtgtcatct acatcatcag agtcgttcga 3300 gtcaatggag tcctggctgt ccacatggtc gtcatcatct tcatcatcca tatcatccat 3360 gtggtcatgg ctttcgttgg acttacttgg aagggtctct tgtttaaagt cattggtttc 3420 ttcagaggac acagcattct gtggggctag gagattctgc ttctgagatg ggtcagggtt 3480 tagccatgtg gccacagcat ctgggtattt gttgtaaagc tgcttttcct cagaacttcc 3540 agaatcagcc tgtttaactg gtatggcaca ggtgatgcct aggaggcaaa agcaaatcac 3600 tgcaattctc atggtagtga gttttccttg gtcggcgttt ggctgagaag gctgcaactg 3660 gcctgagacg agtctggtcc cgacgatgct gtgctctgcc tcctcctgct gctctgaggg 3720 tctcgatgta attggtgccg tatgctcgcc gtgtgaagtc tagcaagttg aactgaatct 3780 ggttccagcc gtcatccagc cgcatgggca tggtgcagat gaagggtttg acccgggtgg 3840 tgctctggta gttacttgcc cgaaagcgac gacgcacatt cttgtcatct agtacctcga 3900 gccgaattct 3910 <210> 165 <211> 8877 <212> DNA <213> Homo sapiens <400> 165 gggtggttgg tggatgtcac agcttgggct ttatctcccc cagcagtggg gactccacag 60 cccctgggct acataacagc aagacagtcc ggagctgtag cagacctgat tgagcctttg 120 cagcagctga gagcatggcc tagggtgggc ggcaccattg tccagcagct gagtttccca 180 gggaccttgg agatagccgc agccctcatt tgcaggggaa gatgattcct gccagatttg 240 ccggggtgct gcttgctctg gccctcattt tgccagggac cctttgtgca gaaggaactc 300 gcggcaggtc atccacggcc cgatgcagcc ttttcggaag tgacttcgtc aacacctttg 360 atgggagcat gtacagcttt gcgggatact gcagttacct cctggcaggg ggctgccaga 420 aacgctcctt ctcgattatt ggggacttcc agaatggcaa gagagtgagc ctctccgtgt 480 atcttgggga attttttgac atccatttgt ttgtcaatgg taccgtgaca cagggggacc 540 aaagagtctc catgccctat gcctccaaag ggctgtatct agaaactgag gctgggtact 600 acaagctgtc cggtgaggcc tatggctttg tggccaggat cgatggcagc ggcaactttc 660 aagtcctgct gtcagacaga tacttcaaca agacctgcgg gctgtgtggc aactttaaca 720 tctttgctga agatgacttt atgacccaag aagggacctt gacctcggac ccttatgact 780 ttgccaactc atgggctctg agcagtggag aacagtggtg tgaacgggca tctcctccca 840 gcagctcatg caacatctcc tctggggaaa tgcagaaggg cctgtgggag cagtgccagc 900 ttctgaagag cacctcggtg tttgcccgct gccaccctct ggtggacccc gagccttttg 960 tggccctgtg tgagaagact ttgtgtgagt gtgctggggg gctggagtgc gcctgccctg 1020 ccctcctgga gtacgcccgg acctgtgccc aggagggaat ggtgctgtac ggctggaccg 1080 accacagcgc gtgcagccca gtgtgccctg ctggtatgga gtataggcag tgtgtgtccc 1140 cttgcgccag gacctgccag agcctgcaca tcaatgaaat gtgtcaggag cgatgcgtgg 1200 atggctgcag ctgccctgag ggacagctcc tggatgaagg cctctgcgtg gagagcaccg 1260 agtgtccctg cgtgcattcc ggaaagcgct accctcccgg cacctccctc tctcgagact 1320 gcaacacctg catttgccga aacagccagt ggatctgcag caatgaagaa tgtccagggg 1380 agtgccttgt cacaggtcaa tcacacttca agagctttga caacagatac ttcaccttca 1440 gtgggatctg ccagtacctg ctggcccggg attgccagga ccactccttc tccattgtca 1500 ttgagactgt ccagtgtgct gatgaccgcg acgctgtgtg cacccgctcc gtcaccgtcc 1560 ggctgcctgg cctgcacaac agccttgtga aactgaagca tggggcagga gttgccatgg 1620 atggccagga cgtccagctc cccctcctga aaggtgacct ccgcatccag cgtacagtga 1680 cggcctccgt gcgcctcagc tacggggagg acctgcagat ggactgggat ggccgcggga 1740 ggctgctggt gaagctgtcc cccgtctacg ccgggaagac ctgcggcctg tgtgggaatt 1800 acaatggcaa ccagggcgac gacttcctta ccccctctgg gctggcggag ccccgggtgg 1860 aggacttcgg gaacgcctgg aagctgcacg gggactgcca ggacctgcag aagcagcaca 1920 gcgatccctg cgccctcaac ccgcgcatga ccaggttctc cgaggaggcg tgcgcggtcc 1980 tgacgtcccc cacattcgag gcctgccatc gtgccgtcag cccgctgccc tacctgcgga 2040 actgccgcta cgacgtgtgc tcctgctcgg acggccgcga gtgcctgtgc ggcgccctgg 2100 ccagctatgc cgcggcctgc gcggggagag gcgtgcgcgt cgcgtggcgc gagccaggcc 2160 gctgtgagct gaactgcccg aaaggccagg tgtacctgca gtgcgggacc ccctgcaacc 2220 tgacctgccg ctctctctct tacccggatg aggaatgcaa tgaggcctgc ctggagggct 2280 gcttctgccc cccagggctc tacatggatg agagggggga ctgcgtgccc aaggcccagt 2340 gcccctgtta ctatgacggt gagatcttcc agccagaaga catcttctca gaccatcaca 2400 ccatgtgcta ctgtgaggat ggcttcatgc actgtaccat gagtggagtc cccggaagct 2460 tgctgcctga cgctgtcctc agcagtcccc tgtctcatcg cagcaaaagg agcctatcct 2520 gtcggccccc catggtcaag ctggtgtgtc ccgctgacaa cctgcgggct gaagggctcg 2580 agtgtaccaa aacgtgccag aactatgacc tggagtgcat gagcatgggc tgtgtctctg 2640 gctgcctctg ccccccgggc atggtccggc atgagaacag atgtgtggcc ctggaaaggt 2700 gtccctgctt ccatcagggc aaggagtatg cccctggaga aacagtgaag attggctgca 2760 acacttgtgt ctgtcgggac cggaagtgga actgcacaga ccatgtgtgt gatgccacgt 2820 gctccacgat cggcatggcc cactacctca ccttcgacgg gctcaaatac ctgttccccg 2880 gggagtgcca gtacgttctg gtgcaggatt actgcggcag taaccctggg acctttcgga 2940 tcctagtggg gaataaggga tgcagccacc cctcagtgaa atgcaagaaa cgggtcacca 3000 tcctggtgga gggaggagag attgagctgt ttgacgggga ggtgaatgtg aagaggccca 3060 tgaaggatga gactcacttt gaggtggtgg agtctggccg gtacatcatt ctgctgctgg 3120 gcaaagccct ctccgtggtc tgggaccgcc acctgagcat ctccgtggtc ctgaagcaga 3180 cataccagga gaaagtgtgt ggcctgtgtg ggaattttga tggcatccag aacaatgacc 3240 tcaccagcag caacctccaa gtggaggaag accctgtgga ctttgggaac tcctggaaag 3300 tgagctcgca gtgtgctgac accagaaaag tgcctctgga ctcatcccct gccacctgcc 3360 ataacaacat catgaagcag acgatggtgg attcctcctg tagaatcctt accagtgacg 3420 tcttccagga ctgcaacaag ctggtggacc ccgagccata tctggatgtc tgcatttacg 3480 acacctgctc ctgtgagtcc attggggact gcgcctgctt ctgcgacacc attgctgcct 3540 atgcccacgt gtgtgcccag catggcaagg tggtgacctg gaggacggcc acattgtgcc 3600 cccagagctg cgaggagagg aatctccggg agaacgggta tgagtgtgag tggcgctata 3660 acagctgtgc acctgcctgt caagtcacgt gtcagcaccc tgagccactg gcctgccctg 3720 tgcagtgtgt ggagggctgc catgcccact gccctccagg gaaaatcctg gatgagcttt 3780 tgcagacctg cgttgaccct gaagactgtc cagtgtgtga ggtggctggc cggcgttttg 3840 cctcaggaaa gaaagtcacc ttgaatccca gtgaccctga gcactgccag atttgccact 3900 gtgatgttgt caacctcacc tgtgaagcct gccaggagcc gggaggcctg gtggtgcctc 3960 ccacagatgc cccggtgagc cccaccactc tgtatgtgga ggacatctcg gaaccgccgt 4020 tgcacgattt ctactgcagc aggctactgg acctggtctt cctgctggat ggctcctcca 4080 ggctgtccga ggctgagttt gaagtgctga aggcctttgt ggtggacatg atggagcggc 4140 tgcgcatctc ccagaagtgg gtccgcgtgg ccgtggtgga gtaccacgac ggctcccacg 4200 cctacatcgg gctcaaggac cggaagcgac cgtcagagct gcggcgcatt gccagccagg 4260 tgaagtatgc gggcagccag gtggcctcca ccagcgaggt cttgaaatac acactgttcc 4320 aaatcttcag caagatcgac cgccctgaag cctcccgcat cgccctgctc ctgatggcca 4380 gccaggagcc ccaacggatg tcccggaact ttgtccgcta cgtgccaggg cctgaagaag 4440 aagaaggtca ttgtgatccc ggtgggcatt gggccccatg ccaacctcaa gcagatccgc 4500 ctcatcgaga agcaggcccc tgagaacaag gccttcgtgc tgagcagtgt ggatgagctg 4560 gagcagcaaa gggacgagat cgttagctac ctctgtgacc ttgcccctga agcccctcct 4620 cctactctgc ccccccacat ggcacaagtc actgtgggcc cggggctctt gggggtttcg 4680 accctggggc ccaagaggaa ctccatggtt ctggatgtgg cgttcgtcct ggaaggatcg 4740 gacaaaattg gtgaagccga cttcaacagg agcaaggagt tcatggagga ggtgattcag 4800 cggatggatg tgggccagga cagcatccac gtcacggtgc tgcagtactc ctacatggtg 4860 accgtggagt accccttcag cgaggcacag tccaaagggg acatcctgca gcgggtgcga 4920 gagatccgct accagggcgg caacaggacc aacactgggc tggccctgcg gtacctctct 4980 gaccacagct tcttggtcag ccagggtgac cgggagcagg cgcccaacct ggtctacatg 5040 gtcaccggaa atcctgcctc tgatgagatc aagaggctgc ctggagacat ccaggtggtg 5100 cccattggag tgggccctaa tgccaacgtg caggagctgg agaggattgg ctggcccaat 5160 gcccctatcc tcatccagga ctttgagacg ctcccccgag aggctcctga cctggtgctg 5220 cagaggtgct gctccggaga ggggctgcag atccccaccc tctcccctgc acctgactgc 5280 agccagcccc tggacgtgat ccttctcctg gatggctcct ccagtttccc agcttcttat 5340 tttgatgaaa tgaagagttt cgccaaggct ttcatttcaa aagccaatat agggcctcgt 5400 ctcactcagg tgtcagtgct gcagtatgga agcatcacca ccattgacgt gccatggaac 5460 gtggtcccgg agaaagccca tttgctgagc cttgtggacg tcatgcagcg ggagggaggc 5520 cccagccaaa tcggggatgc cttgggcttt gctgtgcgat acttgacttc agaaatgcat 5580 ggtgccaggc cgggagcctc aaaggcggtg gtcatcctgg tcacggacgt ctctgtggat 5640 tcagtggatg cagcagctga tgccgccagg tccaacagag tgacagtgtt ccctattgga 5700 attggagatc gctacgatgc agcccagcta cggatcttgg caggcccagc aggcgactcc 5760 aacgtggtga agctccagcg aatcgaagac ctccctacca tggtcacctt gggcaattcc 5820 ttcctccaca aactgtgctc tggatttgtt aggatttgca tggatgagga tgggaatgag 5880 aagaggcccg gggacgtctg gaccttgcca gaccagtgcc acaccgtgac ttgccagcca 5940 gatggccaga ccttgctgaa gagtcatcgg gtcaactgtg accgggggct gaggccttcg 6000 tgccctaaca gccagtcccc tgttaaagtg gaagagacct gtggctgccg ctggacctgc 6060 ccctgcgtgt gcacaggcag ctccactcgg cacatcgtga cctttgatgg gcagaatttc 6120 aagctgactg gcagctgttc ttatgtccta tttcaaaaca aggagcagga cctggaggtg 6180 attctccata atggtgcctg cagccctgga gcaaggcagg gctgcatgaa atccatcgag 6240 gtgaagcaca gtgccctctc cgtcgagctg cacagtgaca tggaggtgac ggtgaatggg 6300 agactggtct ctgttcctta cgtgggtggg aacatggaag tcaacgttta tggtgccatc 6360 atgcatgagg tcagattcaa tcaccttggt cacatcttca cattcactcc acaaaacaat 6420 gagttccaac tgcagctcag ccccaagact tttgcttcaa agacgtatgg tctgtgtggg 6480 atctgtgatg agaacggagc caatgacttc atgctgaggg atggcacagt caccacagac 6540 tggaaaacac ttgttcagga atggactgtg cagcggccag ggcagacgtg ccagcccatc 6600 ctggaggagc agtgtcttgt ccccgacagc tcccactgcc aggtcctcct cttaccactg 6660 tttgctgaat gccacaaggt cctggctcca gccacattct atgccatctg ccagcaggac 6720 agttgccacc aggagcaagt gtgtgaggtg atcgcctctt atgcccacct ctgtcggacc 6780 aacggggtct gcgttgactg gaggacacct gatttctgtg ctatgtcatg cccaccatct 6840 ctggtctaca accactgtga gcatggctgt ccccggcact gtgatggcaa cgtgagctcc 6900 tgtggggacc atccctccga aggctgtttc tgccctccag ataaagtcat gttggaaggc 6960 agctgtgtcc ctgaagaggc ctgcactcag tgcattggtg aggatggagt ccagcaccag 7020 ttcctggaag cctgggtccc ggaccaccag ccctgtcaga tctgcacatg cctcagcggg 7080 cggaaggtca actgcacaac gcagccctgc cccacggcca aagctcccac gtgtggcctg 7140 tgtgaagtag cccgcctccg ccagaatgca gaccagtgct gccccgagta tgagtgtgtg 7200 tgtgacccag tgagctgtga cctgccccca gtgcctcact gtgaacgtgg cctccagccc 7260 acactgacca accctggcga gtgcagaccc aacttcacct gcgcctgcag gaaggaggag 7320 tgcaaaagag tgtccccacc ctcctgcccc ccgcaccgtt tgcccaccct tcggaagacc 7380 cagtgctgtg atgagtatga gtgtgcctgc aactgtgtca actccacagt gagctgtccc 7440 cttgggtact tggcctcaac cgccaccaat gactgtggct gtaccacaac cacctgcctt 7500 cccgacaagg tgtgtgtcca ccgaagcacc atctaccctg tgggccagtt ctgggaggag 7560 ggctgcgatg tgtgcacctg caccgacatg gaggatgccg tgatgggcct ccgcgtggcc 7620 cagtgctccc agaagccctg tgaggacagc tgtcggtcgg gcttcactta cgttctgcat 7680 gaaggcgagt gctgtggaag gtgcctgcca tctgcctgtg aggtggtgac tggctcaccg 7740 cggggggact cccagtcttc ctggaagagt gtcggctccc agtgggcctc cccggagaac 7800 ccctgcctca tcaatgagtg tgtccgagtg aaggaggagg tctttataca acaaaggaac 7860 gtctcctgcc cccagctgga ggtccctgtc tgcccctcgg gctttcagct gagctgtaag 7920 acctcagcgt gctgcccaag ctgtcgctgt gagcgcatgg aggcctgcat gctcaatggc 7980 actgtcattg ggcccgggaa gactgtgatg atcgatgtgt gcacgacctg ccgctgcatg 8040 gtgcaggtgg gggtcatctc tggattcaag ctggagtgca ggaagaccac ctgcaacccc 8100 tgccccctgg gttacaagga agaaaataac acaggtgaat gttgtgggag atgtttgcct 8160 acggcttgca ccattcagct aagaggagga cagatcatga cactgaagcg tgatgagacg 8220 ctccaggatg gctgtgatac tcacttctgc aaggtcaatg agagaggaga gtacttctgg 8280 gagaagaggg tcacaggctg cccacccttt gatgaacaca agtgtctggc tgagggaggt 8340 aaaattatga aaattccagg cacctgctgt gacacatgtg aggagcctga gtgcaacgac 8400 atcactgcca ggctgcagta tgtcaaggtg ggaagctgta agtctgaagt agaggtggat 8460 atccactact gccagggcaa atgtgccagc aaagccatgt actccattga catcaacgat 8520 gtgcaggacc agtgctcctg ctgctctccg acacggacgg agcccatgca ggtggccctg 8580 cactgcacca atggctctgt tgtgtaccat gaggttctca atgccatgga gtgcaaatgc 8640 tcccccagga agtgcagcaa gtgaggctgc tgcagctgca tgggtgcctg ctgctgcctg 8700 cctgccttgg cctgatggcc aggccagagt gctgccagtc ctctgcatgt tctgctcttg 8760 tgcccttctg agcccacaat aaaggctgag ctcttatctt gcaaaaaaaa tctatgtcgg 8820 gtgcggagaa agaggtaatg aaatggcagg atatcgatat gagcttatcg ataccgt 8877 <210> 166 <211> 6115 <212> DNA <213> Homo sapiens <400> 166 cccacaaact ggttgcattt gttgatttat ttttccatcc ttttcaccag taaagattat 60 catcgtttat ttttgttttt aaagttgaaa acaaaaaaga ggagagaaca gagttatggt 120 atgaatgtat gtaaaactat agagaactac agtaatatgt actgtggtta ttgctgtctt 180 cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ggtaggcaac 240 tcggaatctg aaggaatctt gtctgacaac tgtgctatcc atgtgggcta cggtgtgaca 300 gtggcggtag agaggatgga aaaataaatc aacaaactgg ttgcatttgt tgatttattt 360 ttccatcctt ttcaccagta aagattatca tcgtttattt ttgtttttaa agttgaaaac 420 aaaaaagagg agagaacaga gttatggtat gaatgtatgt aaaactatag agaactacag 480 taatatgtac tgtggttatt gctgtcttca aaaaaaataa gatgaaagat aaacaactac 540 aacatacaac gaaaacaacc ggtaggcaac tcggaatctg aaggaatctt gtctgacaac 600 tgtgctatcc atgtgggcta cggtgtgaca gtggcggtgg agaggagact ccggctggcg 660 accggggact ggtggagtgg ggtgagtggg cacagggaag ctggggtccc cttcccctcg 720 gaccctcccc accttccctt tccccatcca aaaggatttc aggagaggag gccagagtct 780 gtgaaatgac taaactatat actccattag aaaaccaaga aagtatgttt gaaatagaaa 840 caaaagccta agagaaaata aaaagtggag aaacagtgca atgtaattct tgcactttag 900 tggttttaaa aacacagaca gtacaaggcc caggttgctg gctggtgaaa cccctgtccc 960 tcgtccctcc tccactttgc aaaacggagc ctcctttctc ttggaagcca gacatatcct 1020 ctctgacgct atggggtttc ttctccttag agctcttctc tgaggttccc attctgggcc 1080 ggagccctct caggagtgag tggatgggtc cggggtactg tcccaccttg agggggggct 1140 tggcggttgc cgtggcagcc ctgtctcact aaccggtgcg tggcgggagc aggtggttga 1200 ggcccaccct ctaggggagg ccagccctgt gggggtacca tggaggccac agaggtggtg 1260 gtggggagat ggggtgggag agaaggggca tgatcagaaa agggcctccc tggacctcgt 1320 gcgcctgcct tcctcccctc atggggccag tgtccccagg cctgtctgtc taggcctggc 1380 tgtcaaagaa aggttccagt ctcttcctcc ccatgtgccc tgctttgcca ggtgggtcag 1440 ggcaggctgg aggaaggagg gtcagtcctg gctgggcttc cctatctcct ggcagtcgtg 1500 ggaaagacag aggcatcttc ctcactggcg gagtgaggca cgaatctaaa ggggatggga 1560 gagaccttct gtgggtgtga gcgtgggagt gggcagcact tagattcgga gccatggata 1620 gtccggagtc caaggtctct gggtgagcag acagtcggcc aaaggccagc ctggagtcaa 1680 agagaccaga cccctgctta gattgccata ctcgcaccat tccaaacctg cctccctcac 1740 accctgccat gggggaagag gtgccgtctt cctccagtgc ctcccttccc aggatctccc 1800 caccctgggc tcagccagaa ctcccatttg ggaggcttag ttccatgtgt ccatgaaggc 1860 ccagcttccc tggggagtga ccagctgccc aggagaaact cctgcatgca gaagagactc 1920 acaggtttgg gttcgcaggc acgaactttg gaaaccggaa gagtctggcg cacttacacc 1980 aggctctaat cccccacctg atggctggca gcaaagagcc aacgcaaggg gcagaagcct 2040 gctcaaagtc cagacacagt ccgtgaagag agagcccctc tcaagaatca ggtccaggct 2100 gggaggaatg tggggggagc ttgtagttcc tggctcagtc ttttctcagg ggagtggcac 2160 cccagtatcc acttggcaga tcctagttgg ataactgctc aagatgcaaa gggagaatgg 2220 gtggaaagaa cagtgacgtg gaagaggttt gggatactgg cctaagacat acagaaacgt 2280 gagttgggtt taggggacag ctgtgcagag agatggggca tgctgactcg gcaggtcaag 2340 tccttgtggc tgctggccct atcaggcccc tttgtctcat gaagattgag cacttctcct 2400 gtccccagcc aactgtcctg tcccggggca taggagatag cacccaagtg ctatagctat 2460 agggttccca tcagttgaaa cagatttgct ttttcgctat tcctcttcgt agccccaaat 2520 tcgttgttgg aggcggtctc cgctgtgtca tgccatgagc aaagagtgaa gagagctgtg 2580 tccacagcac gaaggggtct ccttggccag tgtccaagcc ccctttcctg gatatcttca 2640 gccttaaaga acagtcacaa ggccacccat tggttgagga agtcattgga gaatgggagt 2700 ttcggaatct ggctgccgag tgacagcatc cctgaatcat gcgttccctg cttgtcccag 2760 ctttccttcc atcctccacc ccagggagga tgcagggact ggccagaatg gaggaagagc 2820 tggaaagact cgtgggcctc agtccctcgt tgcaggctga aggtgggcag cggagcgcat 2880 agtcttgtcc cttccaaagc atggccagtt tcgactgatt cttcctatct ggcttctaaa 2940 gtctagcacc ctcctaaagt tactcacctt ccctggctct gcggcctgga ttaagctcat 3000 ttctattttg caacccattc ccccattttc ctctctttcc tctcaaatcc cagaaaatac 3060 atatggtggg gaagctaagg aaatttctat tggcttttcc ccctttctgc tgctttgtgc 3120 caaagctaga atggaacagt cagccccctc tcccttcagc cctctgttcc tccccacatc 3180 gactctggcc ggaaccatcc atcttactgt tctcctgcat ctaaaccttt ttgccaccat 3240 ctccctctgc catctcttac ttcagtctcc ctcctgctct gccagcatgg agagtgaggg 3300 aggctgggag gaatgtgggg ggagcttgta gttcctggct cagtcttttc tcaggggagt 3360 ggcaccccag tatccacttg gcagatccta gttggataac tgctcaagat gcaaagggag 3420 aatgggtgga aagaacagtg acgtggaaga ggtttgggat actggcctaa gacatacaga 3480 aacgtgagtt gggtttaggg gacagctgtg cagagagatg gggcatgctg actcggcagg 3540 tcaaggcctt gtgactgttc tttaaggctg aagatatcca ggaaaggggg cttggacact 3600 ggccaaggag accccttcgt gctgtggaca cagctctctt cactctttgc tcatggcatg 3660 acacagcgga gaccgcctcc aacaacgaat ttggggctac gaagaggaat agcgaaaaag 3720 caaatctgtt tcaactgatg ggaaccctat agctatagaa cttgggggct atctcctatg 3780 cccctggaca ggacagttgg ctggggacag gagaagtgct caatcttcat gagacaaagg 3840 ggcccgatag ggccagcagc cacaaggcct tgacctgccg agtcagcatg ccccatctct 3900 ctgcacagct gtcccctaaa cccaactcac gtttctgtat gtcttaggcc agtatcccaa 3960 acctcttcca cgtcactgtt ctttccaccc attctccctt tgcatcttga gcagttatcc 4020 actaggatct gccaagtgga tactggggtg ccactcccct gagaaaagac tgagccagga 4080 actacaagct ccccccacat tcctcccagc ctggacctaa ttcttgagag gggctctctc 4140 ttcacggact gtgtctggac tttgagcagg cttctgcccc ttgcgttggc tctttgctgc 4200 cagccatcag gtgggggatt agagcctggt gtaagtgcgc cagactcttc cggtttccaa 4260 agttcgtgcc tgcgaaccca aacctgtgag tctcttctgc atgcaggagt ttctcctggg 4320 cagctggtca ctccccagag aagctgggcc ttcatggaca catggaacta agcctcccaa 4380 atgggagttc tggctgagcc cagggtgggg agatcctggg aagggaggca ctggaggaag 4440 acggcacctc cttcccccat tggcagggtg ctgagggagg ccaggtttgg aatggtgcga 4500 gtatggcaat ctaagcaggg gtctggtctc tttgactcca ggctggcctt tggccgactg 4560 tctgctcacc cagagacctt ggactccgga ctatccatgg ctccgaatct aagtgctgcc 4620 cactcccatg ctcacaccca cagaaggtct tcccatcccc tttagattcg tgcctcactc 4680 caccagtgag gaagatgcct ctgtctttcc cacgactgcc aggagatagg gaagcccagc 4740 caggactgac cctccttcct ccagcctgcc ctgacccacc tggcaaagca gggcacatgg 4800 ggaggaagag actggaacct ttctttgaca gccaggccta gacagacagg cctggggaca 4860 ctggccccat gaggggagga aggcaggcgc acgaggtcca gggaggccct tttctgatca 4920 tgccccttct ctcccacccc atctccccac caccacctct gtggcctcca tggtaccccc 4980 acagggctgg cctcccctag agggtgggcc tcaaccacct gctcccgcca cgcaccggtt 5040 agtgagacag ggctgccacg gcaaccgcca agcccccctc aaggtgggac agtaccccgg 5100 acccatccac tcactcctga gagggctccg gcccagaatg ggaacctcag agaagagctc 5160 taaggagaag aaaccccata gcgtcagaga ggatatgtct ggcttccaag agaaaggagg 5220 ctccgttttg caaagtggag gagggacgag ggacaggggt ttcaccagcc agcaacctgg 5280 gccttgtact gtctgtgttt ttaaaaccac taaagtgcaa gaattacatt gcactgtttc 5340 tccacttttt attttctctt aggcttttgt ttctatttca aacatacttt cttggttttc 5400 taatggagta tatagtttag tcatttcaca gactctggcc tcctctcctg aaatcctttt 5460 ggatggggaa agggaaggtg gggagggtcc gaggggaagg ggaccccagc ttccctgtgc 5520 ccgctcaccc cactccacca gtccccggtc gccagccgga gtctcctctc taccgccact 5580 gtcacaccgt agcccacatg gatagcacag ttgtcagaca agattccttc agattccgag 5640 ttgcctaccg gttgttttcg ttgttgtagt agttgttttt ctttttcttt ttttttttga 5700 agacagcaat aaccacagta catattactg tagttctcta tagttttaca tacattcata 5760 ccataactct gttctctcct cttttttgtt ttcaacttta aaaacaaaaa taaacgatga 5820 taatctttac tggtgaaaag gatggaaaaa taaatcaaca aatgcaacca gttttgtgag 5880 aaaaaaaaaa aaaagcgccg aaaaaaaaaa aaaacacctg aatgcggaag agctcggctc 5940 ctgtttagca ttttgtactt aaggaaataa aaaaccaaca aaggatctca cattttctta 6000 aaaagtgaag attgctgtat actatttatt caacttataa tttatgttac tccttgatct 6060 ttgtcttttg tcatgacaaa gcatttattt aataaagtta tgcattcagt taaaa 6115 <210> 167 <211> 1573 <212> DNA <213> Homo sapiens <400> 167 catggacctc ctgtgcaaga acatgaagca cctgtggttc ttcctcctgc tggtggcggc 60 tcccagatgg gtcctgtccc agctgcaact gcaggagtcg ggcccaggat tggtgaagcc 120 ttcggagacc ctgtccctca cctgcactgt ctctggtggc tccatcagca gttataatca 180 ctactggggc tgggtccgcc agcccccagg gaaggggctg gaatggattg ggagtatctt 240 ttatactggg aattcttact acaacccgtc cctcaagagt cgactcgcca tatcagtaga 300 cacgtccaag agccagctct ccctgaagct gagctctgtg accgccgcgg acacggccgt 360 gtattactgt gcgacagttc ctaaaacccg gtctcgacca cgtggataca cctatggtcc 420 ctttgactac tggggccagg gaatcctggt caccgtctcc tcagcatccc cgaccagccc 480 caaggtcttc ccgctgagcc tctgcagcac ccagccagat gggaacgtgg tcatcgcctg 540 cctggtccag ggcttcttcc cccaggagcc actcagtgtg acctggagcg aaagcggaca 600 gggcgtgacc gccagaaact tcccacccag ccaggatgcc tccggggacc tgtacaccac 660 gagcagccag ctgaccctgc cggccacaca gtgcctagcc ggcaagtccg tgacatgcca 720 cgtgaagcac tacacgaatc ccagccagga tgtgactgtg ccctgcccag ttccctcaac 780 tccacctacc ccatctccct caactccacc taccccatct ccctcatgct gccacccccg 840 actgtcactg caccgaccgg ccctcgagga cctgctctta ggttcagaag cgaacctcac 900 gtgcacactg accggcctga gagatgcctc aggtgtcacc ttcacctgga cgccctcaag 960 tgggaagagc gctgttcaag gaccacctga gcgtgacctc tgtggctgct acagcgtgtc 1020 cagtgtcctg ccgggctgtg ccgagccatg gaaccatggg aagaccttca cttgcactgc 1080 tgcctacccc gagtccaaga ccccgctaac cgccaccctc tcaaaatccg gaaacacatt 1140 ccggcccgag gtccacctgc tgccgccgcc gtcggaggag ctggccctga acgagctggt 1200 gacgctgacg tgcctggcac gcggcttcag ccccaaggac gtgctggttc gctggctgca 1260 ggggtcacag gagctgcccc gcgagaagta cctgacttgg gcatcccggc aggagcccag 1320 ccagggcacc accaccttcg ctgtgaccag catactgcgc gtggcagccg aggactggaa 1380 gaagggggac accttctcct gcatggtggg ccacgaggcc ctgccgctgg ccttcacaca 1440 gaagaccatc gaccgcttgg cgggtaaacc cacccatgtc aatgtgtctg ttgtcatggc 1500 ggaggtggac ggcacctgct actgagccgc ccgcctgtcc ccacccctga ataaactcca 1560 tgctccccca agc 1573 <210> 168 <211> 4363 <212> DNA <213> Homo sapiens <400> 168 tgctgattta gtaccatcca ttgctgcaac accagattac gacaatactg catgatttaa 60 cacacaacca cacacacaaa gcacacgcgc acacgcacat acatgtacaa agggatattt 120 tggtggtggt ggattttttt ttgtcttttg tcttcctatt cacattacaa aaggaaaggg 180 caaggttctg cagaactgac gaaggaacta acagatacta caaaaatatt acaatttgtg 240 aagattagct caaccctctc agcttttatg aatggagcgg ggaggggccc aggctgagtg 300 ggaagggcat gggagtgagg gggccagcta gttctatgga atagtttgat ttttttctct 360 tccttcccca ccaatgttga atgacatctt gctgttaaaa atactgtttt ctgggattta 420 cagatcccct gagggccagc caggaaagaa gagttggagt gagatgaagg aaggactatg 480 acaaatnnnn nnnnnnnnnn nnnnnnnnnn nngaaggaaa aggaaacctg gtagcttttt 540 ggccttggat tctctctggg ctccagatga cctggatgcc aagccactgc ccctcctctg 600 ggggcctcca ccctcctctc ccggctggag gtttgcctga ttttctggga tggggttggg 660 tattttgttc actcaaatgg tggcacattt ttctccttcc ttcacccaga ccttctttta 720 tgtgtccaga aatggaggct agaaagcagg tgagaggtcc tctggtcaga gccacacggt 780 ctgtgccggc cttcctccac caagaccccc aggagatgaa gggagggagg aggtgagcca 840 gaagggcgct cccctgctga tgggtctggg ctgggtcact agctgctcaa aatggcagct 900 ctagtttgct ggcggctgac tggggaggag aagggctctg tttctcttcc caccactcag 960 cccacctgct gctttcctct gctttgccac atctgggtgt cccccggtgg tctctgagag 1020 cctcaggacc cctgcccctc ctccagctct ttgttcccag cctccccttg actcctgtcc 1080 tccaagtccc aggggagtcc cagcccctca gggacctggc ggtgtctcca tccttctccg 1140 gttccctagt gggatagctg cctctgactt cagggtccct cctaccctca gccttctgag 1200 aacacaaaac aaatccaata ccccacccta gtccagcacc atcgtgagca agattcctgc 1260 tgcgctgctt ccaaaatgga aaagcatcac aactaaatac ctaatatcct accaaacaaa 1320 ccacagtccc tacgtagccc tacttcagtc ccaggagaag gaatccatga atgggctgag 1380 gttccgaggg taggttgtgg atgtctttct ctagaggggt cccacacctg gaaaagagga 1440 cacccagccc gtgggatgag ggaagctggg caagggagaa agttgttgag tcacactggg 1500 gaccccagat gtagtgagct cagcaagaaa agccaggtcc agagagagtc gcacagaatt 1560 cctgactcac agcgcccctc ggtccacagt ggannnnnnn nnnnnnnnnn nnnnnnnnnn 1620 nnnnaggact gcaggaggag gaggatctga aagcgctttg gccttgtgtt atgttttgct 1680 tcttttctgt gtcccctgtt agcacattgt acttgaatta cctcagtttt ttgtgacctc 1740 atgagctttc ttaacctctg tatctctttt tcggttgggg cttggaggaa tggggagggt 1800 gttcttttct gtttcttgtg taaattaata gttgttttta tagacttcag ctggtcaaga 1860 ccctccccgt gcccctggag accagcctcc cagctggcag gaactgtgca ggaggagttg 1920 atactcagga tctgaatgtg agggccgagg agggcgaaga gcgtgggtgg ggaggggatg 1980 ttgctttggg gtctcatggt ccccagaggg cactagggag tcacttttgg ctccgctggt 2040 gcatgaagtc acctgtggcc accatccgtt ccgcctaaaa cactctggag agaatcccac 2100 ctttcttaca atttgctggg ccattgaggt ttgagggcct gtgtttggat ccttgcaact 2160 gtgtggtctc acctctgtgc gtgcattctc attgccagaa ttggtctatt ttcacggctg 2220 gtctttgggg aggggggcgg gatccagcct ttgttttgtt gtgttggggt gggggtgttg 2280 tttttctaaa agctacctct tatgtttgtc cagttgttct tttgttcctt tcccgcctcc 2340 cattctgctg ctcttcctcc ctcttttccc caacctcccc cgaccctcct gaattttgga 2400 aagcacattt gcaatattcg tgtttgcttt gggacggacc ctccgtttca tctcatgctt 2460 tatgtgtaag agttttttat tattattttt tctttccttt ctctctctga gaaagttgtg 2520 gctgcgtttt gatcttaggt tttacaaagt ggtttaggga agcggttttg gggagaagga 2580 tcacgaggaa tgtagggaag ccggagggat gggtgctgct gcgacgaccc ccccgtccct 2640 cggccccagc cctcctgccc tccccttcaa tctcatccac caaatctgaa ggccttaaaa 2700 ttgtgtgttg ggaggatgtg aattgggagg acggtgtcac tagactgtgg attagggatg 2760 gtaaagtagg gaggatgcta ttttgcaact atagtaacga cttagtgttt tggaaaggaa 2820 aagaagttaa acttgaaata cgtgactaga acagttgtca tgtttataat gtgaaaaggg 2880 tgaaatcatt tgggggaggg gccgtctgta agaaatcatt atgcactatg gcttcctcct 2940 ctggtctggg aagaagcggg gactggctgg ccctcagggg atctgtaaat cccagaaaac 3000 agtattttta acagcaagat gtcattcaac attggtgggg aaggaagaga aaaaaatcaa 3060 actattccat agaactagct ggccccctca ctcccatgcc cttcccactc agcctgggcc 3120 cctccccgct ccattcataa aagctgagag ggttgagcta atcttcacaa attgtaatat 3180 ttttgtagta tctgttagtt ccttcgtcag ttctgcagaa ccttgccctt tccttttgta 3240 atgtgaatag gaagacaaaa gacaaaaaaa aaatccacca ccaccaaaat atccctttgt 3300 acatgtatgt gcgtgtgcgc gtgtgctttg tgtgtgtggt tgtgtgttaa atcatgcagt 3360 attgtcgtaa tctggtgttg cagcaatgga tggtactaaa tcagcacctg gatgccccac 3420 ccaaccccgt gggccctgca gaccccagta gggaggtatg gggagagctc aggggagtgt 3480 ggtttctgag ggctactgtc tggggacacc tctgaactta ctgtaccttc ctctccccat 3540 gaagacacct gaatagagtc taacatgcct cttctccaac ttcctaccta caacaacaga 3600 acagttctaa tgttgcacgg cctagtggcc agggggcaag ctaagaggct gtctggaggc 3660 tttatatgtg tctggagtta aggggagagg aggagggtag acaggggtct ctccccaggt 3720 gggatctgaa tatctgtcct cccctcttct tcatgccacc tgactccttc ggccccctgg 3780 ctgcctttag ctgtggtact gctgacaacc ctgcttgcta ctgccttatc cagcacagtg 3840 aaaaacttct ccagcctggc aaggccacgt tggttaatag tccctttccc atgtccagct 3900 cctacaaata tgtcccttaa tgcatttggt gacatttaca cctcactcat gtgctctttc 3960 cctattcact ccttcactca ttcaaagcat taaaatccta tgtatatata ggatagacaa 4020 atatatagat atatagatat atatatatat agcaagagat tgatataaaa tagtaaatat 4080 cattgctgct ttgggctgct ttggaggagg aggccatgaa tatggggaag gcagatctgg 4140 ggtgcagggg taggtaggga ggctggggga cccagtgatt cagtacaatc caagggatgc 4200 aacgcgggct tgtttaatct ttgtgcctga acagtttttc catgttgaga aaaaaaagaa 4260 aaaaaaactg ctgcaatttt tcacaagtgt atggtacctt tctggatgct attggtacaa 4320 ttgctgtgga tggaagaggg ccattgagct tacctccagc cgg 4363 <210> 169 <211> 1147 <212> DNA <213> Homo sapiens <400> 169 actagtctcg agtttttttt ttctctgcct cctttgtgtc tgttttaaag gagactaact 60 ccaggagtag gaaatgattc atcatcctcc aaagcaagag gcttaagaga gaaacaccga 120 aattcagata gctcagggac tgctaacaga gaactacatt tttcttattg ccttgaaagt 180 taaaaggaaa gcagatttct ccagtgactt tgtggtccta ctaactacaa ccagtttggg 240 tgacagggct ggtaaagtcc cagtgttaga tgagtgacct aaatatactt agatttctaa 300 gtatggtgct ctcaggtcca agttcaacta ttcttaagca gtgcaattct tcccagttat 360 ttgagatgaa agatctctgc ttattgaaga tgtaccttct aaaactttcc taaaagtgtc 420 tgatgttttt actcaagagg ggagtggtaa aattaaatac tctattgttc aattctctaa 480 aatcccagaa cacaatcaga aatagctcag gcagacacta ataattaaga acgctcttcc 540 tcttcataac tgctttgcaa gtttcctgtg aaaacatcag tttcctgtac caaagtcaaa 600 atgaacgtta catcactcta acctgaacag ctcacaatgt agctgtaaat ataaaaaatg 660 agagtgttct acccagtttt caataaacct tccaggctgc aataaccagc aaggttttca 720 gttaaagccc tatctgcact ttttatttat tagctgaaat gtaagcaggc atattcactc 780 acttttcttt gcctttcctg agagttttat taaaacttct cccttggtta cctgttatct 840 tttgcacttc taacatgtag ccaataaatc tatttgatag ccatcaaagg aataaaaagc 900 tggccgtaca aattacattt caaaacaaac cctaataaat ccacatttcc gcatggctca 960 ttcacctgga ataatgcctt ttattgaata tgttcttata gggcaaaaca ctttcataag 1020 tagagttttt tatgtttttt gtcatatcgg taacatgcag ctttttcctc tcatagcatt 1080 ttctatagcg aatgtaatat gcctcttatc ttcatgaaaa ataaatattg cttttgaaca 1140 aaactaa 1147 <210> 170 <211> 1902 <212> DNA <213> Homo sapiens <400> 170 caactctccc ttcctccctg gctttcagcc atgtccctga ctgctgagca actggcttcc 60 gagtcatcat agaagaagct gttacagctc aggaacatgc tgctcattga ggagtgttga 120 acttcaacct gaggggtccg acagtgccct ccaagacaga gtacgactga acttttgggt 180 ggagactaga ggcaggagct gagggactga ttccggtggt tggcacgggt tcgcacaccc 240 attcaagcgg caggacgcac ttgtcttagc agttctcgct gaccgcgcta gctgcggctt 300 ctacgctccg gcactctgag ttcatcagca aacgccctgg cgtctgtcct caccatgcct 360 agcctttggg accgcttctc gtcgtcgtcc acctcctctt cgccctcgtc cttgccccga 420 actcccaccc cagatcggcc gccgcgctca gcctgggggt cggcgacccg ggaggagggg 480 tttgaccgct ccacgagcct ggagagctcg gactgcgagt ccctggacag cagcaacagt 540 ggcttcgggc cggaggaaga cacggcttac ctggatgggg tgtcgttgcc cgacttcgag 600 ctgctcagtg accctgagga tgaacacttg tgtgccaacc tgatgcagct gctgcaggag 660 agcctggccc aggcgcggct gggctctcga cgccctgcgc gcctgctgat gcctagccag 720 ttggtaagcc aggtgggcaa agaactactg cgcctggcct acagcgagcc gtgcggcctg 780 cggggggcgc tgctggacgt ctgcgtggag cagggcaaga gctgccacag cgtgggccag 840 ctggcactcg accccagcct ggtgcccacc ttccagctga ccctcgtgct gcgcctggac 900 tcacgactct ggcccaagat ccaggggctg tttagctccg ccaactctcc cttcctccct 960 ggcttcagcc agtccctgac gctgagcact ggcttccgag tcatcaagaa gaagctgtac 1020 agctcggaac agctgctcat tgaggagtgt tgaacttcaa cctgaggggg ccgacagtgc 1080 cctccaagac agagacgact gaacttttgg ggtggagact agaggcagga gctgagggac 1140 tgattcctgt ggttggaaaa ctgaggcagc cacctaaggt ggaggtgggg gaatagtgtt 1200 tcccaggaag ctcattgagt tgtgtgcggg tggctgtgca ttggggacac atacccctca 1260 gtactgtagc atgaaacaaa ggcttagggg ccaacaaggc ttccagctgg atgtgtgtgt 1320 agcatgtacc ttattatttt tgttactgac agttaacagt ggtgtgacat ccagagagca 1380 gctgggctgc tcccgcccca gcctggccca gggtgaagga agaggcacgt gctcctcaga 1440 gcagccggag ggagggggga ggtcggaggt cgtggaggtg gtttgtgtat cttactggtc 1500 tgaagggacc aagtgtgttt gttgtttgtt ttgtatcttg tttttctgat cggagcatca 1560 ctactgacct gttgtaggca gctatcttac agacgcatga atgtaagagt aggaaggggt 1620 gggtgtcagg gatcacttgg gatctttgac acttgaaaaa ttacacctgg cagctgcgtt 1680 taagccttcc cccatcgtgt actgcagagt tgagctggca ggggaggggc tgagagggtg 1740 ggggctggaa cccctccccg ggaggagtgc catctgggtc ttccatctag aactgtttac 1800 atgaagataa gatactcact gttcatgaat acacttgatg ttcaagtatt aagacctatg 1860 caatattttt tacttttcta ataaacatgt ttgttaaaac ag 1902 <210> 171 <211> 5735 <212> DNA <213> Homo sapiens <400> 171 ccatggatgg taacttctcc agcaatcaga gcgctccccc tcacatcagt ggcatgcttc 60 atggagatat gctcctctca ctgccctctg gcaccaggca acatggcatt gtcagctctc 120 catcctcctc cttctcagct gctctgttct cgacagcttc ggggaactga ttccgcagcc 180 ttccaatgaa gtcaatctac tggattcaaa aacaattcaa ggggagctgg gctggatctc 240 ttatccatca catgggtggg aagagatcag tggtgtggat gaacattaca cacccatcag 300 gacttaccag gtgtgcaatg tcatggacca cagtcaaaac aattggctga gaacaaactg 360 ggtccccagg aactcagctc agaagattta tgtggagctc aagttcactc tacgagactg 420 caatagcatt ccattggttt taggaacttg caaggagaca ttcaacctgt actacatgga 480 gtctgatgat gatcatgggg tgaaatttcg agagcatcag tttacaaaga ttgacaccat 540 tgcagctgat gaaagtttca ctcaaatgga tcttggggac cgtattctga agctcaacac 600 tgagattaga gaagtaggtc ctgtcaacaa gaagggattt tatttggcat ttcaagatgt 660 tggtgcttgt gttgccttgg tgtctgtgag agtatacttc aaaaagtgcc catttacagt 720 gaagaatctg gctatgtttc cagacacggt acccatggac tcccagtccc tggtggaggt 780 tagagggtct tgtgtcaaca attctaagga ggaagatcct ccaaggatgt actgcagtac 840 agaaggcgaa tggcttgtac ccattggcaa gtgttcctgc aatgctggct atgaagaaag 900 aggttttatg tgccaagctt gtcgaccagg tttctacaag gcattggatg gtaatatgaa 960 gtgtgctaag tgcccgcctc acagttctac tcaggaagat ggttcaatga actgcaggtg 1020 tgagaataat tacttccggg cagacaaaga ccctccatcc atggcttgta cccgacctcc 1080 atcttcacca agaaatgtta tctctaatat aaacgagacc tcagttatcc tggactggag 1140 ttggcccctg gacacaggag gccggaaaga tgttaccttc aacatcatat gtaaaaaatg 1200 tgggtggaat ataaaacagt gtgagccatg cagcccaaat gtccgcttcc tccctcgaca 1260 gtttggactc accaacacca cggtgacagt gacagacctt ctggcacata ctaactacac 1320 ctttgagatt gatgccgtta atggggtgtc agagctgagc tccccaccaa gacagtttgc 1380 tgcggtcagc atcacaacta atcaggctgc tccatcacct gtcctgacga ttaagaaaga 1440 tcggacctcc agaaatagca tctctttgtc ctggcaagaa cctgaacatc ctaatgggat 1500 catattggac tacgaggtca aatactatga aaagcaggaa caagaaacaa gttataccat 1560 tctgagggca agaggcacaa atgttaccat cagtagcctc aagcctgaca ctatatacgt 1620 attccaaatc cgagcccgaa cagccgctgg atatgggacg aacagccgca agtttgagtt 1680 tgaaactagt ccagactctt tctccatctc tggtgaaagt agccaagtgg tcacgatcgc 1740 catttcagcg gcagtagcaa ttattctcct cactgttgtc atctatgttt tgattgggag 1800 gttctgtggc tataagtcaa aacatggggc agatgaaaaa agacttcatt ttggcaatgg 1860 gcatttaaaa cttccaggtc tcaggactta tgttgaccca catacatatg aagaccctac 1920 ccaagctgtt catgagtttg ccaaggaatt ggatgccacc aacatatcca ttgataaagt 1980 tgttggagca ggtgaatttg gagaggtgtg cagtggtcgc ttaaaacttc cttcaaaaaa 2040 agagatttca gtggccatta agaccctgaa agttggctac acagaaaagc agaggagaga 2100 cttcctggga gaagcaagca ttatgggaca gtttgaccac cccaatatca ttcgactgga 2160 aggatgttgt taccaaaagt aagccagtta tgattgtcac agaatacatg gagaatggtt 2220 ccttggatag tttcctacgt aaacacgatg cccagtttac tgtcattcag ctagtgggga 2280 tgcttcgagg gatagcatct ggcatgaagt acctgtcaga catgggctat gttcaccgag 2340 acctcgctgc tcggaacatc ttgatcaaca gtaacttggt gtgtaaggtt tctgatttcg 2400 gactttcgcg tgtcctggag gatgacccag aagctgctta tacaacaaga ggagggaaga 2460 tcccaatcag gtggacatca ccagaagcta tagcctaccg caagttcacg tcagccagcg 2520 atgtatggag ttatgggatt gttctctggg aggtgatgtc ttatggagag agaccatact 2580 gggagatgtc caatcaggat gtaattaaag ctgtagatga gggctatcga ctgccacccc 2640 ccatggactg cccagctgcc ttgtatcagc tgatgctgga ctgctggcag aaagacagga 2700 acaacagacc caagtttgag cagattgtta gtattctgga caagcttatc cggaatcccg 2760 gcagcctgaa gatcatcacc agtgcagccg caaggccatc aaaccttctt ctggaccaaa 2820 gcaatgtgga tatcactacc ttccgcacaa caggtgactg gcttaatggt gtccggacag 2880 cacactgcaa ggaaatcttc acgggcgtgg agtacagttc ttgtgacaca atagccaaga 2940 tttccacaga tgacatgaaa aaggttggtg tcaccgtggt tgggccacag aagaagatca 3000 tcagtagcat taaagctcta gaaacgcaat caaagaatgg cccagttccc gtgtaaagca 3060 cgggacggaa gtgcttctgg acggaagtgg tggctgtgga aggcgtagca tcatcctgca 3120 gacagacaat aattctggag atactggtgg aagttccaag tccaataaga cactcaaata 3180 tgagtacaaa tgccttaaaa tggaattgaa aaactcttta ttttccccta tcatttattg 3240 gatgggtggg tggggtattt ttttgtaatt gcttttttaa atattagtta atggattaaa 3300 tttaattctt cagcgtaaaa tggtgaagaa ctagcatata gccattgatc ataaactgac 3360 tatcataaaa tcaaaacaag tgaaataaca aaatggacat ggtggctttg tttaggtaga 3420 gccacaaaag aaaagacttg taatattttt atatacagag gaaatctgta acaggtattt 3480 tgtttctttt aaagcaagca acacagagga atttatacct caaactatct ggccatattt 3540 actaccttat cactgcatta ttctctttta tctgtttaaa gcatatagag atgaagtttg 3600 tagttgtttt aagtactaca catttttaaa ttgttagctt ccttaagtat atcatgtaaa 3660 gaaatgtctt aatttttgaa aaaagtacat atttattttc ttttgaattg tttttattgt 3720 tttctattta tgccttgatg atttaatatg gatttgttac agccaagtgc caaatgctct 3780 ctcaaattgt cagcaattta actagacaca gataataatg ggtttctttc agattttttg 3840 aaccatccac ttacatatat ttttaaaaaa tgaaatcctt ttcctgttca tacactaacc 3900 aaatctctca aatctgttat cccaatcatt gttgcctctc cgtttattat aaactgtatg 3960 ctcacaactt agtgtaatat accagcttgt atgcaatgga ttttcaacca gataacatac 4020 ctttcctgct ctggtgctta gagactatca actccctcct ttagtgaagg agccgtgtta 4080 gagcttccga gaatagctcc actggagaga agtggaatcc tatatagaat gctgcactaa 4140 ttgacaacac agcctatagg ccaatgcatg agtaaaaaaa aaaacaatta ctggctcact 4200 ggctttgaaa agtcacttac tattgttgct gaaacttgct gagctgttta tagagaatga 4260 tgataacaga acttttcctc tgtatcactg gtgtttaggt gaattaatta aacattgtga 4320 tcattagtac caggtattat tatctttaag agtcttccac ttcaatgcac atggtgcagt 4380 tttggtgtgt aacttagaag gattgaactt ctttgaattt actggacata acattttcag 4440 aatagttggt catctagcaa acgcctcaaa atgtgtaagc aggagagaaa tttctcatca 4500 cagggattta gacttactat tacataaagg ctaactatga gcttgctcat taattttgaa 4560 aagatgtacc tggtggatat ctagctagta atatattctg aagcaacatt ttagctctat 4620 tgatactctt tctaatgctg atatgatctt gagtataaga aatgcatatg tcactagaat 4680 ggataaaata atgctgcaaa cttaatgttc ttatgcaaaa tggaacgcta atgaaacaca 4740 gcttacaatc gcaaatcaaa attcacaagt gctcatctgt tgtagattta gtgtaataag 4800 acttagattg tgctccttcg gatatgattg tttctcaaat cttggcaata ttccttagtc 4860 aaatcaggct actagaattc tgtattggat atataagagc atgaaatttt taaaaataca 4920 cttgtgatta taaaattaat cacaaatttc acttatacct gctatcagca gctagaaaac 4980 attttttttt taaatcaagt attttgtgtt tggaatgtta gaatgagatc tgaatgtggt 5040 ttcaatctaa ttttttccca gactactatt ttctttttta ggtactattc tgagcatact 5100 caacaaaacc catgcatttc ataaactaat agaagttgag gattgttgaa tctatttcac 5160 ttattttggc tgtggtttcc atctgaaagt agaggttgta tacaccatat actgttcttc 5220 attttattaa tatttttctc cttgacctct cataaattta ctttacacaa ttcttaccct 5280 gtacatatgt aaacataagt gtacgattct taaccatgga gtagaggtac tagaatgctt 5340 acggccatct ctttgtacag gaactgcatt gactttcagt aaacataaag ccacaactcc 5400 tacatgatgt tatgtaccat atgatctgtt ttgtatctta aatttgattt acatatatta 5460 tttatttctg gtaactcact cagtttatgc tgtgctaaat atcaatcaag ccatgtataa 5520 atgtgatatg attggcaata tgtgtttact ttaaacttgt cttttcaaaa tattactcag 5580 tttatgttgt acaatgtaga tggcctctta ctaatgtaaa atgatttgta gtggaaacat 5640 ttatattttt ataataaaca taatgaaaat attttttaca gattggaata aaaaaaatct 5700 atgtcgggtg cggagaaaga ggtaatgaaa tggca 5735 <210> 172 <211> 13220 <212> DNA <213> Homo sapiens <400> 172 tattgtcttt ctccgcggcg aaggtgaaga gttgtcccag ctcggcccgc gggggagccc 60 cgggagccgc acgtgtcctg ggtcatgaaa cttaatccac agcaagctcc cttatatggt 120 gattgtgttg ttacagtgct gcttgctgaa gaggacaaag ctgaagatga tgtagtgttt 180 tacttggtat ttttgggttc caccctccgt cactgtacaa gtactcggaa ggtcagttct 240 gatacattgg agaccattgc tcctggtcat gattgttgtg aaacagtgaa ggtgcagctc 300 tgtgcttcca aagagggcct tcccgtgttt gtggtggctg aagaagactt tcatttcgtc 360 caggatgaag cgtatgatgc agctcaattc ctagcaacca gtgctggaaa tcagcaggct 420 ttgaacttta cccgttttct tgaccagtca ggacccccat ctggggatgt gaattccctt 480 gataagaagt tggtgctggc attcaggcac ctgaagctgc ccacggagtg gaatgtattg 540 gggacagatc agagtttgca tgatgctggc ccgcgagaga cattgatgca ttttgctgtg 600 cggctgggac tgctgaggtt gacgtggttc ctgttgcaga agccaggtgg ccgcggagct 660 ctcagtatcc acaaccagga aggggcgacg cctgtgagct tggccttgga gcgaggctat 720 cacaagctgc accagcttct aaccgaggag aatgctggag aaccagactc ctggagcagt 780 ttatcctatg aaataccgta tggagactgt tctgtgaggc atcatcgaga gttggacatc 840 tatacattaa cctctgagtc tgattcacat catgaacacc catttcctgg agacggttgc 900 actggaccaa tttttaaact tatgaacatc caacagcaac taatgaaaac aaacctcaag 960 cagatggaca gtcttatgcc cttaatgatg acagcacagg atccttccag tgccccagag 1020 acagatggcc agtttcttcc ctgtgcaccg gagcccacgg accctcagcg actttcttct 1080 tctgaagaga ctgagagcac tcagtgctgc ccagggagcc ctgttgcaca gactgaaagt 1140 ccctgtgatt tgtcaagcat agttgaggag gagaatacag accgttcctg taggaagaaa 1200 aataaaggcg tggaaagaaa aggggaagag gtggagccag cacctattgt ggactctgga 1260 actgtatctg atcaagacag ctgccttcag agcttgcctg attgtggagt aaagggcacg 1320 gaaggccttt cgtcctgtgg aaacagaaat gaagaaactg gaacaaaatc ttctggaatg 1380 cccacagacc aggagtccct gagcagtgga gatgctgtgc ttcagagaga cttggtcatg 1440 gagccaggca cagcccagta ttcctctgga ggtgaactgg gaggcatttc aacaacaaat 1500 gtcagtaccc cagacactgc aggggaaatg gaacatgggc tcatgaaccc agatgccact 1560 gttcggaaga atgtgcttca gggaggggaa agtacaaagg aaagatttga gaactctaat 1620 attggcacag ctggagcctc tgacgtgcac gtcacaagta agcctgtgga taaaatcagt 1680 gttccaaact gtgcccctgc cgccagttcc ctggatggta acaaacctgc tgagtcttca 1740 cttgcattta gtaatgaaga aacctccact gaaaaaacag cagaaacgga aacttcacga 1800 agttgtgagg agagtgctga tgctccagta gatcagaatt ctgtggtgat tccagctgct 1860 gcaaaagaca agatttcaga tggattagaa ccttatactc tcttagcagc aggcataggt 1920 gaggcaatgt caccctcaga tttagccctt cttgtgctgg aagaagatgt aatgccacac 1980 cagaactcag aaacaaattc atctcatgct caaagccaaa agggcaaatc ctcacccatt 2040 tgttctacaa ctggagacga taaactttgt gcagactctg catgtcaaca gaacacagtg 2100 acttctagtg gcgatttggt tgcaaaactg tgtgataaca tagttagcga gtccgaaagc 2160 accacagcaa ggcaacccag ctcacaagat ccacccgatg cctcccactg tgaagaccca 2220 caggctcata cagtcacctc tgaccctgta agggataccc aggaacgtgc ggatttttgt 2280 cctttcaaag tggtggataa caaaggccaa cgaaaagatg tgaaactaga taaaccttta 2340 acaaatatgc ttgaggtggt ttcacatcca catccagttg tccctaaaat ggagaaagaa 2400 ctggtgccag accaggcagt aatatcagac agtactttct ctctggcaaa cagtccaggc 2460 agtgaatcag taaccaagga tgacgcactt tcttttgtcc cctcccagaa agaaaaggga 2520 acagcaactc ctgaactaca tacagctaca gattatagag atggcccaga tggaaattcg 2580 aatgagcctg atacgcggcc actagaagac agggcagcag gcctgtccac atcctccact 2640 gctgcagagc ttcagcacgg gatggggaat accagtctca caggacttgg tggagagcat 2700 gagggtcctg cccctccagc aatcccagaa gctctgaata tcaaggggaa cactgactct 2760 tccctgcaaa gtatgggtaa ggccactttg gctttagatt cagttttgac tgaagaagga 2820 aaacttctgg tggtttcaga aagctctgca gctcaggaac aagataagga taaagcggtg 2880 acctgttcct ctattaagga aaatgctctc tcttcaggaa ctttgcagga agagcagaga 2940 acaccacctc ctggacaaga tactcaacaa tttcatgaaa aatcaatctc agctgactgt 3000 gccaaggaca aagcacttca gctaagtaat tcaccgggtg catcctctgc ctttcttaag 3060 gcagaaactg aacataacaa ggaagtggcc ccacaagtct cactgctgac tcaaggtggg 3120 gctgcccaga gcctggtgcc accaggagca agtctggcca cagagtcaag gcaggaagcc 3180 ttgggggcag agcacaacag ctccgctctg ttgccatgtc tgttgccaga tgggtctgat 3240 gggtccgatg ctcttaactg cagtcagcct tctcctctgg atgttggagt gaagaacact 3300 caatcccagg gaaaaactag tgcctgtgag gtgagtggag atgtgacggt ggatgttaca 3360 ggggttaatg ctctacaagg tatggctgag cccagaagag agaatatatc acacaacacc 3420 caagacatcc tgattccaaa cgtcttgttg agccaagaga agaatgccgt tctaggtttg 3480 ccagtggctc tacaggacaa agctgtgact gacccacagg gagttggaac cccagagatg 3540 atacctcttg attgggagaa agggaagctg aagggagcag accacagctg taccatgggt 3600 gacgctgagg aagcccaaat agacgatgaa gcacatcctg tcctactgca gcctgttgcc 3660 aagggagctc cccacagaca tggagctctc agcccatgat gatggggccc cagctggtgt 3720 gagggaagtc atgcgagccc cgccttcagg cagggaaagg agcactccct ctctaccttg 3780 catggtctct gcccaggacg cacctctgcc taagggggca gacttgatag aggaggctgc 3840 cagccgtata gtggatgctg tcatcgaaca agtcaaggcc gctggagcac tgcttactga 3900 gggggaggcc tgtcacatgt cactgtccag ccctgagttg ggtcctctca ctaaaggact 3960 agagagtgct tttacagaaa aagtgagtac tttcccacct ggggagagcc taccaatggg 4020 cagtactcct gcaggaagcc acggggagcc ttgcaggatg ttttgctgga agggaggagc 4080 cagagaagat cattttacct gtccaggggc ctgagccagc agcagaaatg ccagacgtga 4140 aagctgaaga tgaagtggat tttagagcaa gttcaatttc tgaagaagtg gctgtaggga 4200 gcatagctgc tacactgaag atgaagcaag gcccaatgac ccaggcgata aaccgagaaa 4260 actggtgtac aatagagcca tgccctgatg cagcatctct tctggcttcc aagcagagcc 4320 cagaatgtga gaacttcctg gatgttggac tgggcagaga gtgtacctca aaacaaggtg 4380 tacttaaaag agaatctggg agtgattctg acctctttca ctcacccagt gatgacatgg 4440 acagcatcat cttcccaaag ccagaggaag agcatttggc ctgtgatatc accggatcca 4500 gttcatccac cgatgacacg gcttcactgg accgacattc ttctcatggc agtgatgtgt 4560 ctctctccca gattttaaag ccaaacaggt caagagatcg gcaaagcctt gatggattct 4620 acagccatgg gatgggagct gagggtcgag aaagtgagag tgagcctgct gacccaggcg 4680 acgtggagga ggaggagatg gacagtatca ctgaagtgcc tgcaaactgc tctgtcctaa 4740 ggagctccat gcgctctctt tctcccttcc ggaggcacag ctgggggcct gggaaaaatg 4800 cagccagcga tgcagaaatg aaccaccgga gttcaatgcg agttcttggg gatgttgtca 4860 ggagacctcc cattcatagg agaagtttca gtctagaagg cttgacagga ggagctggtg 4920 tcggaaacaa gccatcctca tctctagaag taagctctgc aaatgccgaa gagctcagac 4980 acccattcag tggtgaggaa cgggttgact ctttggtgtc actttcagaa gaggatctgg 5040 agtcagacca gagagaacat aggatgtttg atcagcagat atgtcacaga tctaagcagc 5100 agggatttaa ttactgtaca tcagccattt cctctccatt gacaaaatcc atctcattaa 5160 tgacaatcag ccatcctgga ttggacaatt cacggccctt ccacagtacc ttccacaata 5220 ccagtgctaa tctgactgag agtataacag aagagaacta taatttcctg ccacatagcc 5280 cctccaagaa agattctgaa tggaagagtg gaacaaaagt cagtcgtaca ttcagctaca 5340 tcaagaataa aatgtctagc agcaagaaga gcaaagaaaa ggaaaaagaa aaagataaga 5400 ttaaggagaa ggagaaagat tctaaagaca aggagaaaga taagaagact gtcaacgggc 5460 acactttcag ttccattcct gttgtgggtc ccatcagctg tagccagtgt atgaagccct 5520 tcaccaacaa agatgcctat acttgtgcaa attgcagctg tagcagtgct tttgtccaca 5580 aaggctgccg agaaagtcta gcctcctgtg caaaggtcaa aatgaagcag cccaaaggga 5640 gccttcaggc acatgacaca tcatcactgc ccacggtcat tatgagaaac aagccctcac 5700 agcccaagga gcgtcctcgg tccgcagtcc tcctggtgga tgaaaccgct accaccccaa 5760 tatttgccaa tagacgatcc cagcagagtg tctcgctctc caaaagtgtc tccatacaga 5820 acattactgg agttggcaat gatgagaaca tgtcaaacac ctggaaattc ctgtctcatt 5880 caacagactc actaaataaa atcagcaagg tcaatgagtc aacagaatca cttactgatg 5940 agggagtagg tacagacatg aatgaagggc aactactggg agactttgag attgagtcca 6000 aacagctgga agcagagtct tggagtcgga taatagacag caagtttcta aaacagcaaa 6060 agaaagatgt ggtcaaacgg caagaagtaa tatatgagtt gatgcagaca gagtttcatc 6120 atgtccgcac tctcaagatc atgagtggtg tgtacagcca ggggatgatg gcggatctgc 6180 tttttgagca gcagatggat gaaaagctgt tcccctgttt ggatgagctg atcagtatcc 6240 atagccaatt cttccagagg attctggagc ggaagaagga gtctctggtg gataaaagtg 6300 aaaagaactt tctcatcaag aggatagggg atgtgcttgt aaatcagttt tcaggtgaga 6360 atgcagaacg tttaaagaag acatatggca agttttgtgg gcaacataac cagtctgtaa 6420 actacttcaa agacctttat gccaaggata agcgttttca agcctttgta aagaagaaga 6480 tgagcagttc agttgttaga aggcttggaa ttccagagtg catattgctt gtaactcagc 6540 ggattaccaa gtacccagtt ttattccaaa gaatattgca gtgtaccaaa gacaatgaag 6600 tggagcagga agatctagca cagtccttga gcctggtgaa ggatgtgatt ggagctgtag 6660 acagcaaagt ggcaagttat gaaaagaaag tgcgtctcaa tgagatttat acaaagacag 6720 atagcaagtc aatcatgagg atgaagagtg gtcagatgtt tgccaaggaa gatttgaaac 6780 ggaagaagct tgtacgtgat gggagtgtgt ttctgaagaa tgcagcagga aggttgaaag 6840 aggttcaagc agttcttctc actgacattt tagttttcct tcaagaaaaa gaccagaagt 6900 acatctttgc atcattggac cagaagtcaa cagtgatctc tttaaagaag ctgattgtga 6960 gagaagtggc acatgaggag aaaggtttat tcctgatcag catggggatg acagatccag 7020 agatggtaga agtccatgcc agctccaaag aggaacgaaa cagctggatt cagatcattc 7080 aggacacaat caacaccctg aacagagatg aagatgaagg aattcctagt gagaatgagg 7140 aagaaaagaa aatgttggac accagagccc gagaattaaa agaacaactt caccagaagg 7200 accaaaaaat cctactcttg ttggaagaga aggagatgat tttccgggac atggctgagt 7260 gcagcacccc tctcccagag gattgctccc caacacatag ccctagagtt ctcttccgct 7320 ccaacacaga agaggctctc aaaggaggac ctttaatgaa aagtgcaata aatgaggtgg 7380 agatccttca gggtttggtg agtggaaatc tgggaggcac acttgggccg actgtcagca 7440 gccccattga gcaagatgtg gtcggtcccg tttccctgcc ccggagagca gagacctttg 7500 gaggatttga cagccatcag atgaatgctt caaaaggagg cgagaaggaa gagggagatg 7560 atggccaaga tcttaggaga acggaatcag atagtggcct aaaaaagggt ggaaatgcta 7620 acctggtatt tatgcttaaa agaaacagtg agcaggttgt ccagagcgtt gttcatctct 7680 acgagctcct cagcgctctg cagggtgtgg tgctgcagca ggacagctac attgaggacc 7740 agaaactggt gctgagcgag agggcgctca ctcgcagctt gtcccgcccg agctccctca 7800 ttgagcagga gaagcagcgc agcctggaga agcagcgcca ggacctggcc aacctgcaga 7860 agcagcaggc ccagtacctc gaggagaagc gcaggcgcga gcgtgagtgg gaagctcgtg 7920 agagggagct gcgggagcgg gaggccctcc tggcccagcg cgaggaggag gtgcagcagg 7980 ggcagcagga cctggaaaag gagcgggagg agctccagca gaagaagggc acataccagt 8040 atgacctgga gcgactgcgt gctgcccaga aacagcttga gagggaacag gagcagctgc 8100 gccgggaggc agagcggctc agccagcggc agacagaacg ggacctgtgt caggtttccc 8160 atccacatac caagctgatg aggatcccat cgttcttccc cagtcctgag gagcccccct 8220 cgccatctgc accttccata gccaaatcag ggtcattgga ctcagaactt tcagtgtccc 8280 caaaaaggaa cagcatctct cggacacaca aagataaggg gccttttcac atactgagtt 8340 caaccagcca gacaaacaaa ggaccagaag ggcagagcca ggcccctgcg tccacctctg 8400 cctctacccg cctgtttggg ttaacaaagc caaaggaaaa gaaggagaaa ataaagaaga 8460 acaaaaccag ccgctctcag cccggtgatg gtcccgcgtc agaagtatca gcagagggtg 8520 aagagatctt ctgctgaccc tcttcctctc tgctgaggca gctgcctcct gatcctggcc 8580 agcccacctc tcctgcagtc cccgcgtgca caagtctctt acactggacg cccactgctc 8640 ctcagcgtcc agtcctcctg ggcggcccca ggtcctggac aataagcaac agatgatatt 8700 gagtgtcggg tggggaagga ggcccagact ctgcttcggc catgatttgt gactgcccag 8760 gactctcagg ttgggctggc cctactcagg attacactga aagtaatggc ctcgtaagta 8820 caggtgatgg ttttggacac gtcaggaatt cctaaaggct gaaagagtgt atccaagtaa 8880 ggtctgaacc tccgactgcc ttttatttgg gggaacacaa aaccaaacag cagatgtttt 8940 ggacttgatc tgtgtacgta catggggacc tgtctgcata tacacacggg gaatgccaga 9000 agaaggccca gtctgcacca ggcgtctggt caacttagca caagggcagt gcctggacgg 9060 acccggagcc cccgcatatc agcagttcac ccagtactcc tcagagactg gtttccctct 9120 aaacccatcc cgggcacata ccacccctgt tttgcatgta tttctcattt cattttaggg 9180 atgacaaaca tttgtgaaac cagtgagaga aggcttgatg tgtataaaag acgtgatgtg 9240 caccacctcg atctcggtgt ttcaggcact aaagcaacaa aaccacccat agtatctcat 9300 tttgtcatca gatccagaag aaatatcctg gttttccagc atgtttaccc acatgttttg 9360 ggcatggata aagtgaagag gcctactcac cattatccct gcagcgtgac accttttgat 9420 tgtcactgac cactcagaag gggccacggc ctcctggctg tgttcctgag cccccgtcgt 9480 gcctctccca gacagcagct gtctggccct tgctgggtga gggcacacca ctgccagggg 9540 tcagcctcgc acccaggcca ggcagaagct gtgctctgaa gctaggacag ctggctgaga 9600 agtgggttca ggcgaagggt gaagccatgt gtagcagttc ctgccagtgc agatctggag 9660 aggagctggc ccggaaggcg tggttgtgaa agcgcccttc ttatgttagg aggccttggc 9720 aaaattggat ttcttcaaaa atacatgtaa aggtctgttg ttgaattgta ctctgcccct 9780 ggaagcagat acagatggct gcctgctgct cggctttgct tttgcttttc ccaccgtgtt 9840 ttcatctttg ttcacttgag gctttcccca gctggtgtgt gcaggacagt tcatggtaat 9900 gttgccctct gaggccccgt acaccagaag ggaggccctg gaaaattttg tgcttccaac 9960 gtggccttca attcttgctt ttttgcccct cggaagcatg gggcttttga gcacacttaa 10020 aaaaagaaaa atctgtaact tggtgcttat tgatgaattg caagctggcc ttgcagatgg 10080 agatatttat ctttcagttt atttgaaaga ggtctggttt aaaatttgta gcctacattt 10140 gttttattta ttgtatttgt gtgtttgtgt ttgttttttt ttaagggtga gccaggtcta 10200 gcccaacagt ctaaactatc cagtcaatac cgagtgaagt ggcagccagc actgttcact 10260 ctgtgtcttt tgaagtgcct tgaaggccca gatgaaattt taaagggagg gggtccatgt 10320 ccttccctcc cccaccccgc ctcattcttt aatcaaagga tgtcttctcc cttgtttgag 10380 aatgaagaaa ctcgccacct ctgacctacc tttgcctttt tctgtcatgg agaatactca 10440 cccttcagaa acagaccaaa ggccaaaacc tgctgatttt tctattgaaa atatgtcccc 10500 ttgcaaagac cctaaacaaa aagttaagtt tctttctttc acctatttgt acaactccaa 10560 gttacagctg aatctgtcgt gactttcctg agatctaccc ggggcttggc tgtctgttct 10620 gggcactggc tccgagttcc cctcctggga tttgcaggag ggcagtactg aacctgcatt 10680 cttctccttg taaatgtagg ccgggtgccc ctgttctccg ggtttggaac aatacgaggt 10740 tggtgctgat gggatttact tgcgtacgtg ctcttcacaa aaacaccgtg gatgctgaag 10800 ttagagcacg tcgccacaga gcttgacatc aatgttagag ggtctcttac tccccgccca 10860 gctgtgatgt ttcatctgct ttggttgttt tggtggtctt ttttaaaaat agagatttca 10920 catctgccca gaccccactc aaaacgattt ggtcaggttc tggttggaca agtttaaaat 10980 caaagtagtg cccggaattc cctcaaacca cccaacttca tccaggaata cagtctgcag 11040 tgcaccaaca gaaccgctta ccaagaactg tgcttacata cctttgtcat ctctcttccc 11100 cccttggaag ttgtcctcag ggggatttgt tcctgtcctg gggatttacc tgggatggtg 11160 gctgcctgtg cttttgctca tggccttgac agtgctctag ttgctggatc taatggcctg 11220 tcttggtttc tatcaatcac atgagaaggg gttgtttttt tggggtgact cggactgaat 11280 tccccatact gtttccacgc cgggacacca tgttctccat caagctaaag aaatcacgtg 11340 cctgaaactg tgcttaagtt ttgggggaaa gatggagttc ctatccagag cccccagatt 11400 tccagaatcg agtgagcttc ctggaaggag actgcgtctt ctctcaattc cagtcatctc 11460 agtcgttgtc gttaggtgac atgtgcactt taaatgctct catcggttgg cttcattttc 11520 aagacaatca aatgtattga ctgtgttttc ttcttagaaa atggagaggg ttcaaaacat 11580 gcaaactgcc actttcaacc tttgccagta ttccctctac ccccgtgaga gctatctggg 11640 gggaagaatc cttaccaagg tttttttgga aaggtacgaa tcttaacttt tttccccttc 11700 tgtgtctcag ggtaatacta ttcagagtcg cccctttgct cattttctcc cgtatttgtt 11760 accttcctga ggcctcagta ttagtcgtga gcacaaagtt ttgagacctt tggcgttgtt 11820 tcttgatgtg ggaggggagg tgttagtgca tgcaagggtt gaactagata gaccctgcct 11880 tagtagaggg tgggactata accttagagg ccagaacttg atccagaagt tgctgtccac 11940 agaagtgctt tctatttcat catttttgtt tctagggctc tttttctgta gccaggtctt 12000 cccaaggatt ttagtatttg cattggagtt gaggtttact ctaatgatgg tggcccagct 12060 gtgcccagag gacagccagg gcaggccccg ggagggagtt tagaaagaca gtcctggtga 12120 atgggcttca agtggtcaca aagagggtgg ctgtgaggtg accccagaca ctgcagaacg 12180 atgtgcaccc tctgcgtttt ggatgtcctt ggaatgtggg agcctagaaa taaccctgtg 12240 gatggaattg gggcagcggc tgctggagat ctgtgtgcct tgccttcctt cagcaggacc 12300 gtctaggtgc gcagccacct atggatgcgt cccagccagc cccgtcgctc tcgtccatcc 12360 tcagagacaa agaagagggc agggagtttg ggcttggttt tgaactttcc tttcaatgta 12420 gcaaagcatt cctagttaac cagagccttg gaatctactg cctgctggcc aggctttaaa 12480 atgaaaagtg ttttaatgct gccataaaag ggaggcgggg gggaggaagg gaaaataaag 12540 gcatctttcc aagtactcat ctaatttaat tgtcaaaaga ttgataggcc atgaattact 12600 tctccatctc actaagggtt aaaggcgtgc aaccccccac tggctgtgtc ccctgccacc 12660 gaagtgagtg acctgcccta caaccaggtg ggaccacctg tgctgcagtc cggaggggct 12720 tctgcaggaa gcactcaccc cccacacctt ccccggcctg agcttcccct acctttcgtc 12780 accacctgag ggcatgagca caggccatgg ggcgtgcctg gtgagtctgc ctgtggttca 12840 ggcttagcct gtggtctcct gtgtgctgct gcccgcatgg gatgcgcagg ggaggcgtgg 12900 ggatccgcag gagggtggtt gggatacacc ggatacctct gctctcattg cttgtttgca 12960 aatgctctat ggacatttgt gtgctaaatc ctattaaata aaaaagacgg gttaaaaccc 13020 agatgctgta tattcatttg taattatgta taaagtgaag cagttttaaa ctgtaaagat 13080 ttttttcagt gtgttttctc gaatattgcc acaacatact ggcttcgtat tttatttatc 13140 tttctttcta gttaccagct tcagaccctt gtaaagtctc cctcagccct ttcaaaaaat 13200 aataaatttc ctgtgaagtt 13220 <210> 173 <211> 2210 <212> DNA <213> Homo sapiens <400> 173 tgcgcgcgcg cgggtaccac acgtacattg cgcgtgcgta ccgtacgcac gccgcaccac 60 acacacagca cagcacaaga aatccaagag caaaggcctg cggctaacat caatgcccga 120 gagcccgcgg atgcacgacc tgaacgacgc gctggacgag ctgcgcgcgg tgatccccta 180 cgcgcacagc ccctcggtgc gaaagctctc caagatcgcc acgctgctgc tcgccaagaa 240 ctacatcctc atgcaggcgc aggccctgga ggagatgcgg cgcctagtcg cctacctcaa 300 ccagggccag gccatctcgg ctgcctccct gcccagctcg gcggctgcag cggcagcagc 360 tgctgccctg cacccggcgc tcggcgccta cgagcaggca gccggctacc cgttcagcgc 420 cggactgccc ccggctgcct cctgcccgga gaagtgcgcc ctgtttaaca gcgtctcctc 480 cagcctctgc aaacagtgca cggagaagcc ttaaacacac ccccgaaaaa cacaagaccg 540 acccaaaatc tagaggaaag cgaaaagctg ctccccaccc cctttatttt ggtcctctcg 600 tagttgtgaa acacttgcag agcaaacaaa gcagaggcaa gaactgagga gaagtatcag 660 agacaaacgg gacttttagc cttgacatcc ccagaatctc ggtctttggg gtggggaggg 720 atggaggagg gaggtggagt tgggatggag tatggatgtc ttttttttct cagaaaagtg 780 gcaactttgg tggcagccta gaccgcgagg aagtggaatc ttccttaaag gtgaaacata 840 agttgagaag tagtgcttgg ttattaagcc tggagagtgt ttgaatggca aaatactaat 900 cctactaata attgtggatt tggctagtgc tgagggggag aggaggggtt aggggttggg 960 tagcatgaga gatggaatat tcattcagac aaatcagaaa gggcacttga aaataaattt 1020 tgattctgag ccaggagaaa aacttgaaat gttgacttaa gtgaggggga aataaaaccc 1080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnac atgttactat gaaagacttg tattttttat 1140 tgtctctgaa ctttaatcct gtgaaaatgc tcaaagtttt ggcgagagtg atataaaaaa 1200 actgactgtg gctgaaagaa ttgcatttaa aaatatttat gtgcaccttg ttactttcta 1260 ctctgcaatg atgtattaac aattcatggt atttatttgt tattcttcaa tgacccttcc 1320 acatcaacag tatttatcat gtgttaaagt catgggtctt atgtgcagat ttttttaatg 1380 cctctaaaat tgttttatag attacttatg ctgtgtgcca agtgtttaaa ggtttatttg 1440 ccaacaagta tgaagagaaa tattgatgta tctgagctgc ttaggtttat gaaaggtcac 1500 ctggatattt tcagttgcat catccctgta tttaaattga gctttaataa attgcttcag 1560 tccaaaaatt acaggaaagg tgtattctta attgatgaat gaattgatct cttttttgaa 1620 aggggactcc tttacattcc aaaagggaaa aacatcacag caatagttgc tatacgtaag 1680 aacatgctaa gcaaatattt ttccaggctg tgctgtgcat ttttaaaagg tctaatttaa 1740 ttgcttttaa tatatatgta catatatgtt attttaactg tggagaatta tttaagttaa 1800 aagactggtt tgatttgcct atggtgtgaa atcctttgtt atttttctaa aaaaataaaa 1860 tttaaaaaga aagaaaacta aggaagaaca agaagctatt tacccaaagt gagctttcag 1920 ttttagtttt gcatggctgt ttgactgcct ttccgcccta tgaaaatcaa gaaaatcttt 1980 tttaaaaatg gagtcctgct attttccact ccttgcagat aatacaaatt cagtttgtca 2040 ggttggatgg tgagttggga gctgtgatgg atctgttggc gggttttgga tgtgtaaaga 2100 atgatatata tattaaatag gtcaatcaga ctatgacagc tatgtacgac catttgtatg 2160 tgtatctatg tcagaaagaa tctttattaa aatattttga tcaaacattt 2210 <210> 174 <211> 1680 <212> DNA <213> Homo sapiens <400> 174 gaactcccac agcaaaggcc ataaaaccat ccagggcagt ctggggcggc tcagttctgc 60 ggtgccaggg agtggagcag agctcagccc cgtcccaaac acagatggga ccatgaactc 120 cggacacagc ttcagccaga ccccctcggc ctccttccat ggcgccggag gtggctgggg 180 ccggcccagg agcttcccca gggctcccac cgtccatggc ggtgcggggg gagcccgcat 240 ctccctgtcc ttcaccacgc ggagctgccc accccctgga gggtcttggg gttctggaag 300 aagcagcccc ctactaggcg gaaatgagaa gatcaccatg cagaacctca acgaccgcct 360 ggcctcctac ctggagaagg ttcgcgccct ggaggaggcc aacatgaagc tggaaagccg 420 catcctgaaa tggcaccagc agagagatcc tggcagtaag aaagattatt cccagtatga 480 ggaaaacatc acacacctgc aggagcagat agtggatggt aagatgacca atgctcagat 540 tattcttctc attgacaatg ccaggatggc agtggatgac ttcaacctca agtatgaaaa 600 tgaacactcc tttaagaaag acttggaaat tgaagtcgag ggcctccgaa ggaccttaga 660 caacctgacc attgtcacaa cagacctaga acaggaggtg gaaggaatga ggaaagagct 720 cattctcatg aagaagcacc atgagcagga aatggagaag catcatgtgc caagtgactt 780 caatgtcaat gtgaaggtgg atacaggtcc cagggaagat ctgattaagg tcctggagga 840 tatgagacaa gaatatgagc ttataataaa gaagaagcat cgagacttgg acacttggta 900 taaagaacag tctgcagcca tgtcccagga ggcagccagt ccagccactg tgcagagcag 960 acaaggtgac atccacgaac tgaagcgcac attccaggcc ctggagattg acctgcaggc 1020 acagtacagc acgaaatctg ctttggaaaa catgttatcc gagacccagt ctcggtactc 1080 ctgcaagctc caggacatgc aagagatcat ctcccactat gaggaggaac tgacgcagct 1140 acgccatgaa ctggagcggc agaacaatga ataccaagtg ctgctgggca tcaaaaccca 1200 cctggagaag gaaatcacca cgtaccgacg gctcctggag ggagagagtg aagggacacg 1260 ggaagaatca aagtcgagca tgaaagtgtc tgcaactcca aagatcaagg ccataaccca 1320 ggagaccatc aacggaagat tagttctttg tcaagtgaat gaaatccaaa agcacgcatg 1380 agaccaatga aagtttccgc ctgttgtaaa atctattttc ccccaaggaa agtccttgca 1440 cagacaccag tgagtgagtt ctaaaagata cccttggaat tatcagactc agaaactttt 1500 attttttttt tctgtaacag tctcaccaga cttctcataa tgctcttaat atattgcact 1560 tttctaatca aagtgcgagt ttatgagggt aaagctctac tttcctactg cagccttcag 1620 attctcatca ttttgcatct attttgtagc caataaaact ccgcactagc tgaaaagcgc 1680 <210> 175 <211> 2913 <212> DNA <213> Homo sapiens <400> 175 cctgtagctt agacttatag aaagtgatcc gcctgcctgc agaggcgccc ttttcagctg 60 ctgctcgcca gaagcccttg attccactgg ttgacatggc agcagttact ggcaagaggg 120 agaaaggacg ctgccgccta agagtgcaag gctgctcagg tctccaagcg ccgtaggagg 180 tcacctggca gtgactgtag ggagctgggt catagtgcac gtcgtgggta ttaggaaagc 240 ctgtattctt tcaatgaatg tcagtaggac cttcctttag ctgtaagact tggtgggcgg 300 ggtggggtgg ggagggagga aagggtagga agggtgggaa gggagaagca gacatagtca 360 tttatgattt gaaagttgga aatttgtacc atctgtttga gtatatgcac atttaaaaaa 420 tatcatatag taaatgcaaa catgccaagt attttataaa gattaataac agacctactc 480 ttacctggca gtttacttaa cttactgttt tgagtcctaa acttagagtt gttaatgctt 540 atatataatc taaccaaaga gttacccagt agggttttag tttttgaact tttattttct 600 tgttgattat aaatcctgat tttggaatct attgcgcaaa agaagtttca ttttggttac 660 ttagacctaa gatcacttat taaaaatcct tattttctcc aagcccagca aacgttgact 720 tctgggcaaa cctgaaaacc tgaaaatgcc actttcatgc agtttgtttg aagttaagtg 780 gaatcctttc aaatgacgag ctgcagagaa ctcagcacca agggctgcct atctgtagat 840 agctgtaaaa tggaatattt ttaaatgaag gcaaataagt acttaaaagt gagctgagca 900 ataaaatggt ccaataatag gtaaatgcaa cagaaacaga aggagacctg gttgccttat 960 gcctttactc ttacatggaa taaattccca atgcatatcc tatgtaaacc ataagtgaag 1020 ggaaataaac ctcgtcatgc tccatgctgt gaggtgtcct ttggatattc tgtgatgaca 1080 gagaagccta ttttgttttg ttttcagcat ctttctctga tgtacgtttt taaggatttt 1140 gtaagagctg ttttcagtgt ttaaattagt gctatttttc cttgttttta aaaatgaatc 1200 tcgtactgta tcttactatg tccatacaga tgttacaaat cgacagtttt attcttagac 1260 tcatgtgatc caagctgtat ataccatata taaacatttt acatgaatca tttagttttt 1320 taattcattt actaatgcta taaaatttcc tatattaccc cagtaatttg catcagctgg 1380 tttatatact aaagcaacat gttttgatga gtttcttaca tccttatcga ggaattgggt 1440 taggaaaaaa tacataattg taaaactgag tttgctgtat tatacttttt ttcttgagta 1500 ttagttgtat tactaatcat atgttgatta actgtctact taaagtcaag gtacctgtat 1560 ttttaatcca ctaatttttt tttagttggg aaatagattt caggtctttt attagactaa 1620 cattttttga gaagtaaaat tgacttcata tacaaagcct gtaattttag gcgaaatgga 1680 agcagaaatc taggaagttg tgcttgcttg tatgttgagt ttggtctcag actaagtaat 1740 gcatcagaat tcatctgttt gaagcctgaa ataatttagg actctgattc actgaccaaa 1800 agtcagtgtt gcagagattt ctctaccccg tatggtattt tgttagattg ttcaacagga 1860 agcacatgat tgagaacatc ttgggacaga ccaaaaccac tgacagatgg caaggctcgg 1920 cgattctgat ttcccttctc aaatctgctc aactccaaga gtcttgagaa actgctaaaa 1980 ttttgcctct gtcactcaag tcttacaaat gttatcttgt aaacctttga ggtgaactat 2040 tccactgtct tgtacatagg catcttattc actgcaccct gtcacaccca gcaccccccg 2100 ccccgcacat tatttgaaag actgggaatt taatggttag ggacagtaaa tctacttctt 2160 tttccaggga cgactgtccc ctctaaagtt aaagtcaata caagaaaact gtctattttt 2220 agcctaaagt aaaggctgtg aagaaaattc attttacatt gggtagacag taaaaaacaa 2280 gtaaaataac ttgacatgag cacctttaga tcccttcccc tccatgggct ttgggccaca 2340 gaatgaacct ttgaggcctg taaagtggat tgtaatttcc tataagctgt aatagtggag 2400 gtattgtggg ttcatttgag taagccctcc aaagatacca ttcaaataac ctgggagaat 2460 gtcataaatt attcagataa ttatcactgc atgaatctga ttcagaggca tgcatttaca 2520 tatgttgccc taattaccat ttgatgatca taaatacaag tgaatgacat tggactttta 2580 gtaacaaact taatttttaa aaaggtgtag acaatggtgg ttnnnnnnnn nnnnnnnnng 2640 gtaccaggtt ctgtgtgttt gcaccaagta attgacatgt tttttgttta atacatgtgg 2700 accatgaaca gtattcattc tactttttca aatgatatgc tgtagaaaat attccttgaa 2760 gatgtgagat ttaaaaattt ttccctttca atgttgtttt aattgtattt cttacttggt 2820 ttttttgatt gatagcacag tgataaatca taatactaga caaaattgtc ttctctttca 2880 aaccagagcc atatatatgt ctgtatatat ggg 2913 <210> 176 <211> 2071 <212> DNA <213> Homo sapiens <400> 176 ttttctttaa ggtggggaaa gagacaacca agagacagga agctgatctg caaggcattc 60 ggagttgtgc taaaaggact ttgatttttt ttcccccttt acgaacgctg gcaattgaca 120 tcactacaga cagcctggtt agagaacaaa ctgcctcatc ccaagtggac cccggcagct 180 gggggaagcc aggcaagatc tgggaaggct gtgtgtgggt gttttttcta cagatctcac 240 tcctcgccct tttttttttt tcctttggtg tgtgtttttt gttttgtttt gtttttctga 300 aaaaaaattc ttgctgtgtt ggaactagcg agtggtggag tctctgaagc ctcatcagtc 360 accgggactg tcaggaatag tggtttaaga ggaagctcgg cctggggcac tataccctgt 420 catccagttc cctgcctcgg agataaagat tccagctaca tgggcaaacg cctggatcag 480 ccacaaatgt acccccagta cacttactac tatcctcatt atctccaaac caagcagtcc 540 tatgcaccag ctccccaccc catggctcct cccagcccca gcacaaacag cagcagcaac 600 aacagcagca acaacagcag cggggaacag ttgagtaaaa ccaacctgta cattcgaggc 660 ctcccaccag gcaccactga ccaggaccta atcaagctgt gccaaccgta tggaaaaatt 720 gtatctacaa aggcaattct tgacaaaaac acaaatcagt gcaaaggtta tggttttgta 780 gattttgaca gtcctgcagc cgcacagaaa gcggtagcat ctctcaaggc aaatggcgtg 840 caggcacaga tggctaagca acaagagcaa gacccaacaa acctatacat ctcaaatctc 900 cccatttcta tggatgagca ggagcttgag aatatgctga aaccctttgg acatgtcatt 960 tccacaagaa tactaagaga cgctaatgga gtcagcagag gtgttggctt tgccagaatg 1020 gagtctactg aaaaatgtga agtggtaatt caacatttta atggaaaata tctgaaaaca 1080 ccaccaggca tcccagcccc cagtgagcct ttgctgtgca aattcgctga tggaggacag 1140 aagaagcgac agaatcaaag caaatatacc cagaatggga ggccttggcc cagggaagga 1200 gaggctggca tggctttgac ctatgacccc acagctgcca tacagaatgg attttattct 1260 tcaccgtaca gtattgcaac caaccgcatg attccacaga catctatcac gccattcatt 1320 gctgcttccc ctgtctccac ataccaggtc cagagtactt catggatgcc tcatccgcca 1380 tacgttatgc aaccaacagg tgctgtgatt acaccaacca tggaccatcc catgtcaatg 1440 cagccagcca acatgatggg cccactgaca cagcagatga atcacctttc gttgggcaca 1500 acaggaacgt atatgactgc tgctgctcct atgcaaggga cctacattcc tcagtacacg 1560 cctgtgcctc cgacagctgt ttctattgaa ggtgttgttg ctgatacctc tccccagaca 1620 gtggcacctt catcccagga caccagtggt cagcagcaac agatagcagt ggacacatcc 1680 aacgaacatg cacctgcata ttcttaccaa cagtctaaac cataaacagg actgaagaat 1740 gtctgtctga atctttgcct tgaatgaaga aacttcattg aacaagaagt tggcttccag 1800 tttgcacaga cgtcaatgga atgcattttt ttgttgttgt tgttgttttt tttttagtgt 1860 tataccttac ccaatgaaag caaagttttt atgtgctgtg caaatggtct tcatgtggtc 1920 tgacaattta tttttgccat cattttttta attaaagaaa aaatttccag aagaggaaaa 1980 aaaaactaca aaaaacaaaa cattgaaggt tgatatttta tgtggaagaa catttgaatt 2040 gaattcagaa tttttctgaa ggtgtagata c 2071 <210> 177 <211> 1902 <212> DNA <213> Homo sapiens <400> 177 caactctccc ttcctccctg gctttcagcc atgtccctga ctgctgagca actggcttcc 60 gagtcatcat agaagaagct gttacagctc aggaacatgc tgctcattga ggagtgttga 120 acttcaacct gaggggtccg acagtgccct ccaagacaga gtacgactga acttttgggt 180 ggagactaga ggcaggagct gagggactga ttccggtggt tggcacgggt tcgcacaccc 240 attcaagcgg caggacgcac ttgtcttagc agttctcgct gaccgcgcta gctgcggctt 300 ctacgctccg gcactctgag ttcatcagca aacgccctgg cgtctgtcct caccatgcct 360 agcctttggg accgcttctc gtcgtcgtcc acctcctctt cgccctcgtc cttgccccga 420 actcccaccc cagatcggcc gccgcgctca gcctgggggt cggcgacccg ggaggagggg 480 tttgaccgct ccacgagcct ggagagctcg gactgcgagt ccctggacag cagcaacagt 540 ggcttcgggc cggaggaaga cacggcttac ctggatgggg tgtcgttgcc cgacttcgag 600 ctgctcagtg accctgagga tgaacacttg tgtgccaacc tgatgcagct gctgcaggag 660 agcctggccc aggcgcggct gggctctcga cgccctgcgc gcctgctgat gcctagccag 720 ttggtaagcc aggtgggcaa agaactactg cgcctggcct acagcgagcc gtgcggcctg 780 cggggggcgc tgctggacgt ctgcgtggag cagggcaaga gctgccacag cgtgggccag 840 ctggcactcg accccagcct ggtgcccacc ttccagctga ccctcgtgct gcgcctggac 900 tcacgactct ggcccaagat ccaggggctg tttagctccg ccaactctcc cttcctccct 960 ggcttcagcc agtccctgac gctgagcact ggcttccgag tcatcaagaa gaagctgtac 1020 agctcggaac agctgctcat tgaggagtgt tgaacttcaa cctgaggggg ccgacagtgc 1080 cctccaagac agagacgact gaacttttgg ggtggagact agaggcagga gctgagggac 1140 tgattcctgt ggttggaaaa ctgaggcagc cacctaaggt ggaggtgggg gaatagtgtt 1200 tcccaggaag ctcattgagt tgtgtgcggg tggctgtgca ttggggacac atacccctca 1260 gtactgtagc atgaaacaaa ggcttagggg ccaacaaggc ttccagctgg atgtgtgtgt 1320 agcatgtacc ttattatttt tgttactgac agttaacagt ggtgtgacat ccagagagca 1380 gctgggctgc tcccgcccca gcctggccca gggtgaagga agaggcacgt gctcctcaga 1440 gcagccggag ggagggggga ggtcggaggt cgtggaggtg gtttgtgtat cttactggtc 1500 tgaagggacc aagtgtgttt gttgtttgtt ttgtatcttg tttttctgat cggagcatca 1560 ctactgacct gttgtaggca gctatcttac agacgcatga atgtaagagt aggaaggggt 1620 gggtgtcagg gatcacttgg gatctttgac acttgaaaaa ttacacctgg cagctgcgtt 1680 taagccttcc cccatcgtgt actgcagagt tgagctggca ggggaggggc tgagagggtg 1740 ggggctggaa cccctccccg ggaggagtgc catctgggtc ttccatctag aactgtttac 1800 atgaagataa gatactcact gttcatgaat acacttgatg ttcaagtatt aagacctatg 1860 caatattttt tacttttcta ataaacatgt ttgttaaaac ag 1902 <210> 178 <211> 1329 <212> DNA <213> Homo sapiens <400> 178 atttcattca tatatggtat tgcattattt tattttaaag cactggtgag gggacctctt 60 ggtgattcct ggatgatcat acacagagga cttacaccat acaaaaatat tgggcaccgc 120 agtgccagag aagatgcttg aggttagatt ttaaggagtg gggaattgtg aagcccacag 180 atgcgcacgc aatgaccagc aggaaccgga agccctgggt cacccccact ctgcctcatt 240 tctgcctcca ggatgccact gcctctgctt ccaggaaagg caagggggag ggtgcttatc 300 cgtgtctctg gttccagctt cctgtctttg ctccctcccc tctcttagag actgtgcctt 360 cagcaggact cttaatatct gctgcaactt ggagaacctc cctgccctga aatgtgaacc 420 aagcacactt tggttccttc tccgggcggc tctctctgag acccaaggct gcagtccctc 480 agtgctggtg gtatcgtgtg gggatagcaa tacttctctg cccttcattg tctcatctag 540 acatcaagca gggaaaatcc agggagatta aattcatggt gacaagtcct gggcagttct 600 ggtaaacggt ccagttaggg agggagtaga aactattgac tcaaaagagt ttctggctga 660 tctgtggctt tgcctccacc atccctaacc aacctctcat cacagctttg tgtgtgggct 720 gagtgctggc cttaacccta ggcgtggaag agaaaatgtg aggttgttta gatactcatc 780 aggacctcac aggagctgag acttatcagc cagaatgtgt tcttcggaca gtcgtacaca 840 tcttacagaa aaccctcctt gtagagttgg ttgtggtatg tgtttgatgc tataaagctc 900 atttttaatg tgtacacctg ctctagggac gattcgtttg aaagagagta agatgcatta 960 acagaaacta tcctgggatt aggtgaaaaa tgtctagcaa aagaaacaaa gtctttaata 1020 gagtggcctc tttcgctctt cgattatgac tgctgcagtt ttaccccagc agtcagctgt 1080 ctttgtcaac catacgtttt tggagattgg gtctagcaca tgtcaccctt gtccacgttg 1140 tttcacatct ggttaggggg cagattttaa aatgtagttt tgtaatgtta catttaagca 1200 tgataaatga ttagactacc agatgttact agtgctaact ttgtattctt agacattaaa 1260 atgattgaca taaactcttt gtgccttgaa aatgaaacaa attataaaaa tgtttaaatg 1320 gaaccaaaa 1329 <210> 179 <211> 1902 <212> DNA <213> Homo sapiens <400> 179 caactctccc ttcctccctg gctttcagcc atgtccctga ctgctgagca actggcttcc 60 gagtcatcat agaagaagct gttacagctc aggaacatgc tgctcattga ggagtgttga 120 acttcaacct gaggggtccg acagtgccct ccaagacaga gtacgactga acttttgggt 180 ggagactaga ggcaggagct gagggactga ttccggtggt tggcacgggt tcgcacaccc 240 attcaagcgg caggacgcac ttgtcttagc agttctcgct gaccgcgcta gctgcggctt 300 ctacgctccg gcactctgag ttcatcagca aacgccctgg cgtctgtcct caccatgcct 360 agcctttggg accgcttctc gtcgtcgtcc acctcctctt cgccctcgtc cttgccccga 420 actcccaccc cagatcggcc gccgcgctca gcctgggggt cggcgacccg ggaggagggg 480 tttgaccgct ccacgagcct ggagagctcg gactgcgagt ccctggacag cagcaacagt 540 ggcttcgggc cggaggaaga cacggcttac ctggatgggg tgtcgttgcc cgacttcgag 600 ctgctcagtg accctgagga tgaacacttg tgtgccaacc tgatgcagct gctgcaggag 660 agcctggccc aggcgcggct gggctctcga cgccctgcgc gcctgctgat gcctagccag 720 ttggtaagcc aggtgggcaa agaactactg cgcctggcct acagcgagcc gtgcggcctg 780 cggggggcgc tgctggacgt ctgcgtggag cagggcaaga gctgccacag cgtgggccag 840 ctggcactcg accccagcct ggtgcccacc ttccagctga ccctcgtgct gcgcctggac 900 tcacgactct ggcccaagat ccaggggctg tttagctccg ccaactctcc cttcctccct 960 ggcttcagcc agtccctgac gctgagcact ggcttccgag tcatcaagaa gaagctgtac 1020 agctcggaac agctgctcat tgaggagtgt tgaacttcaa cctgaggggg ccgacagtgc 1080 cctccaagac agagacgact gaacttttgg ggtggagact agaggcagga gctgagggac 1140 tgattcctgt ggttggaaaa ctgaggcagc cacctaaggt ggaggtgggg gaatagtgtt 1200 tcccaggaag ctcattgagt tgtgtgcggg tggctgtgca ttggggacac atacccctca 1260 gtactgtagc atgaaacaaa ggcttagggg ccaacaaggc ttccagctgg atgtgtgtgt 1320 agcatgtacc ttattatttt tgttactgac agttaacagt ggtgtgacat ccagagagca 1380 gctgggctgc tcccgcccca gcctggccca gggtgaagga agaggcacgt gctcctcaga 1440 gcagccggag ggagggggga ggtcggaggt cgtggaggtg gtttgtgtat cttactggtc 1500 tgaagggacc aagtgtgttt gttgtttgtt ttgtatcttg tttttctgat cggagcatca 1560 ctactgacct gttgtaggca gctatcttac agacgcatga atgtaagagt aggaaggggt 1620 gggtgtcagg gatcacttgg gatctttgac acttgaaaaa ttacacctgg cagctgcgtt 1680 taagccttcc cccatcgtgt actgcagagt tgagctggca ggggaggggc tgagagggtg 1740 ggggctggaa cccctccccg ggaggagtgc catctgggtc ttccatctag aactgtttac 1800 atgaagataa gatactcact gttcatgaat acacttgatg ttcaagtatt aagacctatg 1860 caatattttt tacttttcta ataaacatgt ttgttaaaac ag 1902 <210> 180 <211> 1405 <212> DNA <213> Homo sapiens <400> 180 ctccctggtc tatatgaaaa tttattacta cagtgttttc accattaata tttatgatct 60 tggtctttcc ttcttgcctt tgtatagggc caaaagagaa acattggcta ctttgacaac 120 cttaaagcgg actccaggaa tatcaccaac agcatgacct ttgcgaccaa atccagctga 180 aaactgcagc ttccttctca ccttgaagaa taatcctaga aaactcacaa aatgtgtgat 240 gcttttgtag gtacctggaa acttgtctcc agtgaaaact ttgatgatta tatgaaagaa 300 gtaggagtgg gctttgccac caggaaagtg gctggcatgg ccaaacctaa catgatcatc 360 agtgtgaatg gggatgtgat caccattaaa tctgaaagta cctttaaaaa tactgagatt 420 tccttcatac tgggccagga atttgacgaa gtcactgcag atgacaggaa agtcaagagc 480 accataacct tagatggggg tgtcctggta catgtgcaga aatgggatgg aaaatcaacc 540 accataaaga gaaaacgaga ggatgataaa ctggtggtgg aatgcgtcat gaaaggcgtc 600 acttccacga gagtttatga gagagcataa gcccaaggga cgttgacctg gactgaagtt 660 cgcattgaac tctacaacat tctgtgggat atattgttca aaaagatatt gttgttttcc 720 atgatttagc aagcaactaa ttttctccca agctgatttt attcaatatg gttacgttgg 780 ttaaataaac tttttttaga tttagaaggt gatgtaatga tgtattcatt gtgcttatga 840 tgtattctta gtcataactg agtgaaggaa atgggaaatt tgcattattt ctttgttctg 900 atatgaataa taacatattt cataataatt caaggtaaaa agggatatct atggatttcc 960 ctaggtagga gataacaagt atgtaccatt actgaatatt aaatccttct ttaccatagc 1020 tacagttaag taggtgtatc tcagaaacct aaggtagttt taaatgtagt gaaattgtcc 1080 acagcaagct ggcccaagtg ctcacatttt atacccgctc tgtcttagtg cgttgcaaga 1140 gaggagtata tacagtagtt cccccttatc cacaggggta cattctaaga ccccccggtg 1200 ggtgactgaa accacagata gtaccgaatc ttatacatac tatgtttttt ttctaaacat 1260 aaatccctac aataaagttt aatttttaaa ttaggcacca taattaataa taaaacagaa 1320 cagttataac aatatactat aataaaatta tgggtatgtg atctctcttt cgctntcccc 1380 tctcnaattt tttanaganc ccccg 1405 <210> 181 <211> 4813 <212> DNA <213> Homo sapiens <400> 181 ggaggcggag gcggccccgg gctcgggcgg ctgggatgga gcagaagagc gcggagcacc 60 ggagggcacg cagctgacgg agctgcgctg cgttcgcctc gtttgcctcg cgccctccac 120 tggagctgtt cgcgcctccc ggctcccacc gcagcccacc cggcagagga gtcgctacca 180 gcgcccagtg cgctctgtca gtccgcaaac tccttgccgc ccgccccggg ctgggcacca 240 aataccaggc taccatggtc tacaagactc tcttcgctct ttgcatctta actgcaggat 300 ggagggtaca gagtctgcct acatcagctc ctttgtctgt ttctcttccg acaaacattg 360 taccaccgac caccatctgg actagctctc cacaaaacac tgatgcagac actgcctccc 420 catccaacgg cactcacaac aactcggtgc tcccagttac agcatcagcc ccaacatctc 480 tgcttcctaa gaacatttcc atagagtcca gagaagagga gatcaccagc ccaggttcga 540 attgggaagg cacaaacaca gacccctcac cttctgggtt ctcgtcaaca agcggtggag 600 tccacttaac aaccacgttg gaggaacaca gcttgggcac tcctgaagca ggcgtggcag 660 ctacactgtc gcagtccgct gctgagcctc ccacactcat ctcccctcaa gctccagcct 720 catcaccctc atccctatca acctcaccac ctgaggtctt ttctgcctcc gttactacca 780 accatagctc cactgtgacc agcacccaac ccactggagc tccaactgca ccagagtccc 840 caacagagga gtccagctct gaccacacac ccacttcaca tgccacagct gagccagtgc 900 cccaggagaa aacaccccca acaactgtgt caggcaaagt gatgtgtgag ctcatagaca 960 tggagaccac caccaccttt cccagggtga tcatgcagga agtagaacat gcattaagtt 1020 caggcagcat cgccgccatt accgtgacag tcattgccgt ggtgctgctg gtgtttggag 1080 ttgcagccta cctaaaaatc aggcattcct cctatggaag acttttggac gaccatgact 1140 acgggtcctg gggaaactac aacaaccctc tgtacgatga ctcctaacaa tggaatatgg 1200 cctgggatga ggattaactg ttctttattt ataagtgctt atccagtaga attaataagt 1260 acctgatgcg cattgaacga caatcttaag ccctgttttg ttggtatggt tgtttttgtt 1320 ttcctccctc tcctctggct gctacaactt cccctttctg gtacaagaag aaccattctt 1380 taaaggtgag tggaggctga tttgcagctg aagtgggcca gccttgcacc agccaggcca 1440 gaccaccatg gtgaaggctt ctttccccac tgcaggaccc actttgagaa ggaccgagga 1500 ggaggatttg ggttgttttg ttaggggtta ctttcagggg aacatttcat ttgtgttatt 1560 tcttaaactt ctatttagga aattacatta agtattaatg aggggaaagg aaatgagctc 1620 tacgaggatt tcaccctgca tgggagagag cagggttttc tcagattcct ttttaatctc 1680 tatttatctg gttgtttctg acaggatgct gcctgcttgg ctctacaagc tggaaagcag 1740 cttcttagct gcctaattaa tgaaagatga aaataggaag tgccctggag ggggccagca 1800 ggtcacgggg cagaatctct caggttgctg tgggatctca gtgtgcccct acctgttctc 1860 ccctccaggc cacctgtctc tgtaaaggat gtctgctctg ttcaaaaggc agctgggatc 1920 ccagcccaca agtgatcagc agagttgcat ttccaaagaa aaaggctatg agatgagctg 1980 agttatagag agaaagggag aggcatgtac ggtgtgggga agtggaagag aagctggcgg 2040 gggagaagga ggctaacctg cactgagtac ttcattagga caagtgagaa tcagctattg 2100 ataatggcca gagatatcca cagcttggag gagcccagag accgtttgct ttatacccac 2160 acagcaactg gtccactgct ttactgtctg ttggataatg gctgtaaaat gtttaaaaac 2220 aaaacaaaac aaaaaagagg cactagtcta tctgcaatta ctcaacgagg cattttcata 2280 ggaaacagac tatgattaat ccatttattc ttcccacaca cttaccttac taagtctttg 2340 ctttaataaa tgagcaaccc tgggtatagt cttaaaattc tgcacaataa attttgagaa 2400 agaattgttc ctctttgtag gtatctgtgt attgcaatca ttctcaacca ggaggtgatt 2460 ttgccccctg actccacccc agggacattc aaaaatgtct ggtgacagtt ttcattgtca 2520 tgacttgggg gtgctactag aagccaggaa tgctgccaaa cattctacca tgcacagcac 2580 aacctannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2640 nnnnatttat cacaatgccc actgtgacag aacaagacac tcacagatta gtgatacgtt 2700 ttatttttaa caaaatgaaa tgatgtgtta agtttttatt tccaaagtgt ttagtttatt 2760 ggctgatggg ttgttcttgg tatgcatggt gaccttttta tttctgtgtg cttcctagag 2820 agctttattt catggcgaca actctgtctt cttgtaacag ctgatattag caagcagcat 2880 cttatgtcct gatttcatat agtagaaaac aaacattggg tccgacttca aaatgtgttg 2940 tattgtccta cagtgtcata aagaacctga aaatgaactt ttgtttctaa agttggacct 3000 tgctgccatg actgtttagt ttacagaaac ttgaccccgg ctcatcctgt ctctggctgt 3060 ggcccggcaa agcactgaaa acccctctgg tctcagagac agtaggggca gtgccacttt 3120 ctacaacctg ccaacccaca cactggagta attctgaaaa aaattattcc taaactctct 3180 aagtgtggac ggagaatgag caagccccag aagtatttta caaccagagt gggtaatgag 3240 gagggggctt actggaatcg tcatatctct gaatattgaa aacaacaact aaaaaagtgg 3300 accttctcag aaaaaaaggg cagcaaatga ccaagggcgc cccttctggc cgtgcttggc 3360 ttgagtaact gtctctcttt ccccaccccc atcacagggc tttcagtttg gcaaaggaaa 3420 agcagataaa aacagaacat tccatatgtt tctttctcca tcggccaaaa acattttgac 3480 acaatgtttg tgaaacacct ttggagaggt gcacttctga atgctgcctc tgccgtaaat 3540 cctggggcaa gggatcagcc tcttcccagg aaccatcgcc ttctataaac cgtgaactca 3600 agcaggcatt ttttttttct taccgaaagg ctgctattgt gcaagggcac ataatgggtc 3660 tgttgctctt attggcttcc aaatgtgcat ggcaaagaga gagatgtggg cctagagcag 3720 atatattcag caaggtgaca gcttcccata acaattctaa cacttcttat cttatgtgag 3780 aataaaatat ttaagggttg aaccttattt tgccaaatgt atcttttctg cttttgaatt 3840 gggcagaaga ttttagcaac tatattctac aaatgttact tataacacac acacacacat 3900 ctgaaatata tgccgaaaat tgacgtcttt gacctcaggg agagcacctg tccaggtctg 3960 cctaaaggaa atggctccag tgggtctaaa caaccacatc ctatccatgg ataggtctag 4020 tcataacact ttagagagaa tgtcagagca ggagggaggc aagccgcctc ttctcggcca 4080 tcgactgcag atgatgaaag agcgggattc aactttgttt tcttttcctg tggccccagt 4140 gaaacctcct gccctccctg cacgtctgtg tcttcatttc taaaatgggg gtgatgcttt 4200 catattgacc tcaccccata ctacctcaca gatgtgttgt gaggattaat aaaattatgt 4260 ctatggtatt ttcagtttct ggagaaaaat acttatagac agtttaacta ttacatagat 4320 atataagtga tctcagtttc ttgtttgctg tgatactaat gtgttgtttt aacttattcc 4380 ataaaatgac agttgtgtcc tagccacatc agacagctat ctaagctctg gactacccct 4440 ttgtgcagct gaatcactgc agggttgacc atgcctggtg ccacagccat ggtttccatt 4500 tctagatgaa aggatggcct aggacatagg tctcaaagac tcttggatca gaatcaggag 4560 attagggaaa acaggatgga tacctgagca ctaacagcag tagacgtaga cctctgtcct 4620 ttaccatctg aggtcttctg gattctttgt ggggttaatt ttgatttgat gtcatctgtt 4680 tgcccttcat cttgcttgca agtgtgcatg gttcaatccc tcacatccag gaaatgaatt 4740 ttgcaattgg gccagatgct aatttgcacg ttgattcacc ttctttgcct ttaagccttt 4800 tttttctttt ttt 4813 <210> 182 <211> 2065 <212> DNA <213> Homo sapiens <400> 182 agccacctgc aagcctgccg acgctggatg gtttgacttc atctgcacac tcttctttct 60 gacccgctct tccagtcaaa atactttttg ctttcggtca ccgtttaaca atggactgga 120 aactttatcc tctccttcac agcatagtac tgcttggaga agtttctgaa tcgtattaaa 180 tagcctcaaa ttaacagatt ttattcctta gccacctggc atccttccac agggtacatc 240 tctctgcatt cctgacagat ttctttgtct ctttatcatt atagttttcc atatatttgc 300 attgttgctg aaaatattta cacatttgtt gcagtaatct tataaggaag atttcaaggg 360 tttaaatgtg atatcactac tctggaaata tcacagctcc ccctccagcc tcttatcccc 420 caactccaat tccatgtccc cactcattaa aggatgttgt gttgttgaca ttgtggtgtg 480 accgaatcct gcagtctttt ataaattcta agaactgtgg gatattctta cttcttggaa 540 gtgaatcctc ttcaaaaaga gaagacaata attctcctat atctgtcact ttttaaaaga 600 aagaaggaaa gacgaaagga cgaagggaat tagtcaatta aggagacaat cgcccctgaa 660 ttatcgatta acagtaaccc aactgagagt gaaatataat tttataatat atgtgtgttc 720 aatatttgat agttaatgct atttagatat atcatttaga cacacttttt ctcaaaacta 780 aattgatttc atttattata ggttcagaaa atgcatgtga aagaacttct tttgcatttt 840 tgcgacaaga attgcctgtg agactcgcca acattctgaa ggaaattgat atcctcccga 900 cccaattagt aaatacctct tcagtgcaat tggttaaaag ctggtaagtg gtgaaccata 960 ttgaagtctc tagttttgaa acagttaccc gggtatgaat tcttatacta tgttaacatc 1020 ataattggaa aacaggtgat ctgaatggta actacttttg aaagatgtaa gaattttaaa 1080 attaatttag ggtaagttat cattagagaa gttataaaac tataaacaga catttttacc 1140 ctgaaaaagt agattacttt ataataaaat tttgagttct aggaaaaatt tgaaaaaaat 1200 tggcatgcaa ttttaatttt caattataga agagcacttt caataataaa agagtttgat 1260 attgcaaaag aaatcctatg cctagaaacc aattcacatg actgctattt agggaaggcc 1320 taatctttgt aacttacaaa gtgattgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380 nnnnnnnnnn nttgtggaat ccttggcaag tgtcttaaac tctttatgcc attgagttat 1440 tattcccatc tgttattaaa gagattaaag tatatgcctc agagggatgt ttgagtgtaa 1500 tgaaatgaga taatccataa aaaagaaaaa aaaaacccct taggacagca cttggcacac 1560 agccagcagt cagtaagtgt cagttgttgt catctcattt tataaatgaa gatactgatg 1620 cttagagaag gtaggtaacc caaaacagca aatttttggg tcacagaagc aggatatgca 1680 caggtagcag acatgcatga gacccttatc ttaatccact gactgcacag ccttttgttc 1740 attgattcaa gaaatacatg tattatatac ctataagaca attacaatct aaaacatata 1800 ttcaatctgt agtatttact attgcagtca agacttacac tcttctatga atgaatgtag 1860 tagaaaaaaa ataaaaagct ttaaaaaaag ttgtttctaa gtattattgc tagaagaaat 1920 gaaaatattt gccaaacaaa acagtcagga aactgaatac tgacctgaaa tagttaaaga 1980 nacattttgc gttaaatttt aagtttgaaa gtcaaggatt aaaagttata gcattttaaa 2040 tttatattat tttccaaatg ttctg 2065 <210> 183 <211> 1298 <212> DNA <213> Homo sapiens <400> 183 ggggacttct ataaaggtta atgaaacgaa agatgcgatc ccagcgaacc tagtcccact 60 gactccctcc ccacacctcc acctgctggt gcctgacaag catgctggcc tctcctccag 120 taggaaccag caggcggagt aaggaagccc gctgcaggca gtagtggggc ggggcctcag 180 aagcagtcag cccagggctc tcggatgcag ggagcctggg cccaaacagc agcttccgga 240 gtcggaagga gctgaggaag aagactgact gaaggagctt gcgacttttc cgcctcggca 300 accggaccca gcagcaagca ggacgggcgg cgctctgcta ctggtcccgt taagccagag 360 tagcccaagc cctgaagtca ctgctcatcc ggaatggaaa tcccgccgac caactaccca 420 gcctccaggg cggccttggt ggcacagaac tacatcaact accagcaggg gaccccgcac 480 agggtgtttg aggtgcagaa ggtcaaacaa gccagcatgg aggatattcc aggaagagga 540 cataagtatc gccttaaatt tgctgttgaa gaaattatac aaaaacaagt taaggtgaac 600 tgcacagctg aagtacttta cccttcaacg ggacaagaaa ctgcaccaga agtcaacttc 660 acatttgaag gagaaactgg aaagaatcca gatgaagaag acaacacatt ttatcaaaga 720 cttaagtcca tgaaggaacc gctagaagca caaaatattc cagacaattt tggaaatgta 780 tctccagaaa tgacgctcgt tctacattta gcctgggttg cctgtggtta tataatatgg 840 caaaattcta ctgaagacac atggtataaa atggtaaaaa ttcaaactgt caagcaagtg 900 caaagaaatg atgactttat tgaattagac tacaccattc tacttcataa tatagcatct 960 caggagatta ttccctggca aatgcaagtt ctctggcatc cacaatacgg cactaaagta 1020 aaacataata gccgtctgcc aaaggaagta caactggaat aaacaaaaac cctaacactg 1080 gaagtgtaaa catgtctatt gatgtgtatg ccaatttcac tggcatctag cttatgaggc 1140 caaataatcc caaagtgtca ctttatataa atgtcttgat tacagtatag aactttatag 1200 agtccataat acaaagtatc actacataaa aatgtcttta aaacagtaat agtggtatgt 1260 atatccaaaa taaaaagctt caatttcagc ctcaaaaa 1298 <210> 184 <211> 540 <212> DNA <213> Homo sapiens <400> 184 gagtgaaaat caggaggggt aataaaatgt tcctcgcatt cccccccgct tttgtgtgtt 60 gtttttgact ttgccttgga gagccagagc ttccgcattt tctttactat tctttttaaa 120 aaaagtttca ctgtgtagag aacatatatg cataaacata ggtcaattat atgtctccat 180 tagaaaaata ataattggaa aacatgttct agaactagtt acaaaaataa tttaaggtga 240 aatctctaat atttataaaa gtagcaaaat aaatgcataa ttaaaatata tttggacata 300 acagacttgg aagcagatga tacagacttc tttttttcat aatcaggtta gtgtaagaaa 360 ttgccatttg aaacaatcca ttttgtaact gaaccttatg aaatatatgt atttcatggt 420 acgtattctc tagcacagtc tgagcaatta aatagattca taagcataaa aaaaatctat 480 gtcggtgcgg agaaagaggt aatgaaatgg caggaattcg attatcaagc ttatcgatac 540 <210> 185 <211> 2586 <212> DNA <213> Homo sapiens <400> 185 tgcaaacatg agaactaatg aaccaaggcg gctgccacca ggaaggaaca gaacgcaggc 60 attcaaccat gacgtctgca cagtgttagt aacatgtcat tgtggtttcg ttctcactgt 120 ggtaaaattt atttctgagc acttaaactg tgttgcatac ccctaatttt ttttttttct 180 gtatcttcct tgccctcaaa taccctgagg tgataaactg ttccagttgt agccaactac 240 cactgcgccc ggccttaaat aaaatattgt agtcattaat ggtgtgtttg aattgaagag 300 ataccaggag atagaggtga agtgcagtac ttttattctt taagaatata gtctttannn 360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480 nnngtttccc attcatatta actccatctt ttaaaaatgt catgattaca aagtgaaaag 540 atttggcttt cttagaggct caatcacaga ggtgaaagtg accttggaaa tcatatactc 600 tatccccatg ttacacagat tagaaaaact gaggttatgg cactgactta ggcaccccca 660 gcaaggcaac ccagggacta caactggcaa tcccaactcc tgggctaggg ctttttctac 720 ctttttttgc attggcctct taaagaggca atgaatacta attcctggca tcagaaaaaa 780 aaaaaggcat gaggtgggag gattcttttt tccctgatgg gaaacagtga ataagaaaaa 840 tctcatcatt cgatggaaga ggtgacttaa taattttatt aatgaatttg atgtcccatg 900 ttttgtagtt ttgttatcat tgaaccatgg gggctggaat ctgcctaaat aattttatct 960 tggtagccag caattatgtt ggtattttat gtgggccttc ccagattttc atattaatga 1020 aatgactaat agtcgtactt aagaggtaac tctactaaag cagaatgaga tctaatatgt 1080 tgtggaaata aaagagtttg cagtggaatg atactctcac tccgtgcttg taaaattgag 1140 ttctattcaa gacggaactg ctatgactgg cctattcaag gcttcatatt tttatacaga 1200 ctatttcaca gaccatagat ttattttaaa agggaaaatc tcacacataa ttaagcagtg 1260 gaaaatgtgc tcaatgctat ggtgcgtcag gccctctgtc taccaggttt ctcccctttc 1320 tgcagagctg tggaccctgt acgtaccaaa caggtgaact tggtccatct ttccttcttc 1380 ctttttttgc acatttgcat ttatatcttc ctgtactaaa agaaacaaat tatttataat 1440 tggggtgaca atataaagga acaaaagatg gggcaatagt tgcttcctag ctggagctgt 1500 aagtccatgt tacagaaact cactatttaa aaagttttaa aagatttatg aaccttgtcc 1560 tacaattcgc tgaatactta tttgtctttt aaactcccct cggtgtatgg atcatcttcg 1620 tcagaatgcc gttgtttcat tgtgaatcag gggaaaatgt taatcatttg gagactgttt 1680 tcttattacc aaatgtacaa tccataagac aactgaaagc aacaactgct gggttcactg 1740 acaaagatta taaaaatcat cacgttcaaa gtagagtttt tagccaaggt caagaactaa 1800 cctggggctg agtcagcgtc tctacccact taaataacag cgtaaagatc tttcactaaa 1860 ttcgttatgt ggtctgtctg gatgtaaacc tatatatttc cttttgaaac agaatcatat 1920 cctgcagact cttggcactc ctgcatagct ttgaccgaat gttcactctc atcgtaatgg 1980 aagatttcta tctatgcaga taatacatgt ttttaaatac tgttttctgt ttagtcctca 2040 atcttcctaa ctcaaattgg ggactgagga gagagaaagg tggttacccc tgttaccgtg 2100 ccatattctt cttgctgctt ttcaacccca cgtgattgtt gattgacggt tctgctataa 2160 tgtgcgtgcc cttcaagttt cagaaaactt tcccaatcat ttcacttcaa tcttaattga 2220 acccaagagt caaagttatt attttctccg aacgtgtttg tgatcttctg ttatattttg 2280 gggcatgtta cctttatggt atataagctg tagtgcatac tctttgtatt gcaaaaaact 2340 ggtcagtaat ttatgtacat gtattccaca ttttagtgtg cttgaagtga caatccatag 2400 tttgtagtag tttgttattt gtcaacttta ccctgtgttt taaggacatc taaacattcc 2460 ttgtcctatc aagatgacaa aagcagaatg taattttttt ttggaagctt cgtgattacc 2520 tgtaacaagt tctgttttta aaacgaatac aaataaagtt agtaactatt tttaaatcag 2580 aaaaaa 2586 <210> 186 <211> 1425 <212> DNA <213> Homo sapiens <400> 186 aaatggactg gtgaacaaat gtgtagcatt tgctgcatgg gttaattcag aagtataaat 60 ttgcccttgg caaatgcata cacctcatgc taccctcaca aaactggaat agccttcacg 120 aagaaattgt ccttgaagct tgtgtctgat ataagcactg gattgtagaa cttgttgctg 180 attttgacct tgtattcaag ttaactgttc cccttggtat ttgtttaata ccctgtacat 240 atctttgatt tcaaccctta gtacatacat gtggtttggt cacttcatgg ctgaggtaag 300 aacatgcttg tggaagacaa gtctgtggct tggtgagtct gtgtggccag cagtctctga 360 tctgtgcagg gtattaatgt gtcagggccg agtgttctgg aatttctcta gaggctcgca 420 tgggctcctg aaccaattgt ttctgtcctg ctggtctgtc tgtcagggtt ggaaaagtcc 480 aagccatagg acccagtttt ctttcttagc tgatgttttc ctgctagaac accatggact 540 gttacttgcc ttgagttgga agtagtttgc atttatacct gtaaatatat ttatcctttt 600 aatttatgta aggttttttt tttgtatgca attctggatt ctttaaagag atgacaatga 660 attttggttt tctactgtta tgtgagaaca tcagtcccca gcaacacgtc attgtgtaag 720 tagaaataaa agcgctgctg ttannnnnnn nnnnnnnnnn nnnnnnnaaa gaagtatttc 780 cctcagtttc ctgttgcttt ttagctttct gtattatact ttacaaatag ttttattttc 840 ccccaaacaa gtgcatacag ttattacaaa agtcaaagta tataaggctt ataataaagt 900 ggaagtcctt catctcactt ctactcactg agttcctgnn nnnnnnnnnn nnnnnnnnnn 960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1020 nnnnnnnnat tatatcaatt ttagacattt tctattgact tctgtcaatg gatgttgaag 1080 atttctctct tttataatag ttcctccttc ctttccctca tatatactta tgccttctat 1140 tggctctcta tatgtattat ttaattttgg ggtaggtcaa caattcagta tttgtattat 1200 ttggacgtaa gtaaaagtat attcgtagtt gagctgaatg aatcttacta gtagatctag 1260 atttccattc ctgtcaactc gtttagttta ttccctggat gttagacgaa tcagccatgc 1320 agggtatgtc ttgcttctgc ctgtgaaact gtggctagat atggtagttt ctgtaggcgc 1380 caacagaaaa tctatgtcgg gtgcggagaa agaggtaatg aaatg 1425 <210> 187 <211> 1126 <212> DNA <213> Homo sapiens <400> 187 ccagcccccg cgcccgcccg cccgccctgc ggtccggtcc tggcgcccgc gcagaaccag 60 ctgtctgagc tgcccgggca gcggggggag cagcgagcgg gcttccgcga gccggagaag 120 gcacaggcct gtcccgggtc ccggcaggtc tgcgcgtctg ttcccagcgc tctgcgaggc 180 ctaaaaagga ggagcaacct gtccagaatc cctgcaggac aggaaaagga ggggaaatct 240 cgacatggaa aaaccctaca ataaaaatga aggaaacctg gaaaacgagg gaaagccaga 300 agatgaagta gagcctgatg atgaaggaaa gtcagacgag gaagaaaagc cagacgtgga 360 ggggaagaca gaatgcgagg gaaagagaga ggatgaggga gagccaggtg atgagggaca 420 actggaagat gagggaagcc aggaaaagca gggcaggtcc gaaggtgagg gcaagccaca 480 aggcgagggc aagccagcct cccaggcaaa gccagagagc cagccgcggg ccgccgaaaa 540 gcgcccggct gaagattatg tgccccggaa agcaaaaaga aaaacggaca gggggacgga 600 cgattccccc aaggactctc aggaggactt acaggaaagg catctgagca gtgaggagat 660 gatgagagaa tgtggagatg tgtcaagggc tcaagaggag ctaaggaaaa aacagaaaat 720 gggtggtttt cattggatgc aaagagatgt acaggatcca ttcgccccaa ggggacaacg 780 gggtgtcagg ggagtgaggg gtggaggtag gggccagagg ggcttacacg atatcccata 840 cctttaatgc ctttggcctt ccattctgat ttctctgatg agaatattgc tggccctgct 900 ttccctggta ggtatttgcc aggcccaatg ctttaacctt aagctgatac tttgctttag 960 atgtcagtct cgttaccagc agccttttga cccaactacg gcgctctata ttttagtaga 1020 ggattttcac ccatgtgcat ggaaaagatg ttcatggtac attgtaaaaa aataaaatta 1080 aaattaaaaa aagtttgcag aaccgcacaa aaaaaaaaaa accaca 1126 <210> 188 <211> 2280 <212> DNA <213> Homo sapiens <400> 188 ccgccgccca gggttctccc gccactgccg cccgcacccc cgcccccgcg gggttaagat 60 cacacacgcg cccacgccgg cccgcggggc gtgcactttc gctgggttcc gtccgccgca 120 gcccaaacag ttaactgaac gggaggggna gggggcgggg cttacccggg gtcaccgcca 180 gggccctgct gggttccacg ccacgttcct gtctccgcag gcgttcgatc cctagaggga 240 ggagcctgtc caaacggacg ctaacggcct acctccccct gaggtgctct tacagcctgt 300 tccaagtgtg gcttaatccg tctccaccac cagatctttc tccgtggatt cctctgctaa 360 gaccgctgcc atgccagtga cggtaacccg caccaccatc acaaccacca cgacgtcatc 420 ttcgggcctg gggtccccca tgatcgtggg gtcccctcgg gccctgacac agcccctggg 480 tctccttcgc ctgctgcagc tggtgtctac ctgcgtggcc ttctcgctgg tggctagcgt 540 gggcgcctgg acggggtcca tgggcaactg gtccatgttc acctggtgct tctgcttctc 600 cgtgaccctg atcatcctca tcgtggagct gtgcgggctc caggcccgct tccccctgtc 660 ttggcgcaac ttccccatca ccttcgcctg ctatgcggcc ctcttctgcc tctcggcctc 720 catcatctac cccaccacct atgtccagtt cctgtcccac ggccgttcgc gggaccacgc 780 catcgccgcc accttcttct cctgcatcgc gtgtgtggct tacgccaccg aagtggcctg 840 gacccgggcc cggcccggcg agatcactgg ctatatggcc accgtacccg ggctgctgaa 900 ggtgctggag accttcgttg cctgcatcat cttcgcgttc atcagcgacc ccaacctgta 960 ccagcaccag ccggccctgg agtggtgcgt ggcggtgtac gccatctgct tcatcctagc 1020 ggccatcgcc atcctgctga acctggggga gtgcaccaac gtgctaccca tccccttccc 1080 cagcttcctg tcggggctgg ccttgctgtc tgtcctcctc tatgccaccg cccttgttct 1140 ctggcccctc taccagttcg atgagaagta tggcggccag cctcggcgct cgagagatgt 1200 aagctgcagc cgcagccatg cctactacgt gtgtgcctgg gaccgccgac tggctgtggc 1260 catcctgacg gccatcaacc tactggcgta tgtggctgac ctggtgcact ctgcccacct 1320 ggtttttgtc aaggtctaag actctcccaa gaggctcccg ttccctctcc aacctctttg 1380 ttcttcttgc ccgagttttc tttatggagt acttctttcc tccgcctttc ctctgttttc 1440 ctcttcctgt ctcccctccc tcccaccttt ttctttcctt cccaattcct tgcactctaa 1500 ccagttcttg gatgcatctt cttccttccc tttcctcttg ctgtttcctt cctgtgttgt 1560 tttgttgccc acatcctgtt ttcacccctg agctgtttct ctttttcttt tctttctttt 1620 tttttttttt ttttaagacg gattctcacc actgtgctcc agcctggggg acagagcgag 1680 actccatctc aaaaaaaaaa aaggaatcgg acgaagaacc acaggatgtt gaagacaact 1740 gtctgaagta tttgtgaggg acagcgatgt ggccctctgt gttaagaata acgtgtcctg 1800 ctttggcaga gagaagaaaa tagccactgc ccgctttcaa ggcaagatcg accttttctg 1860 ttttgttttg tttttctttc tttttcctgg ccatgaggac aaaaattact gagtggccct 1920 taaagaggga agtttgtttt cagctgttct cttttgcccg taggtgggag ggtggggatt 1980 gctgcgtcct agctagagga atggctttgc ttgaatgtgt agtgcacacg cacgggtgtt 2040 tctgtgtgct agttgcttct tgctgctgct tcctgcttgt ctgggactca catacataac 2100 gtgatatata tatatatata taaatgtata aatatatatt ttattttttt ttaaatcctt 2160 ggagcttctg gttcctatca gttcctgttg ttaatcgtag aaccgttgtc ccttccccca 2220 ttcccgtatc catcatgttc tttttctttt aaatatcaat ataaaggtaa aagaaggaaa 2280 <210> 189 <211> 4460 <212> DNA <213> Homo sapiens <400> 189 ctcgagggcg tctccggctg ctcccattga gctgtctgct cgctgtgccc gctgtgcctg 60 ctgtgcccgc gctgtcgccg ctgctaccgc gtctgctgga cgcgggagac gccagcgagc 120 tggtgattgg agccctgcgg agagctcaag cgcccagctc tgccccagga gcccaggctg 180 ccccgtgagt cccatagttg ctgcaggagt ggagccatga gctgcgtcct gggtggtgtc 240 atccccttgg ggctgctgtt cctggtctgc ggatcccaag gctacctcct gcccaacgtc 300 actctcttag aggagctgct cagcaaatac cagcacaacg agtctcactc ccgggtccgc 360 agagccatcc ccagggagga caaggaggag atcctcatgc tgcacaacaa gcttcggggc 420 caggtgcagc ctcaggcctc caacatggag tacatgacct gggatgacga actggagaag 480 tctgctgcag cgtgggccag tcagtgcatc tgggagcacg ggcccaccgg tctgctggtg 540 tccatcgggc agaacctggg cgctcactgg ggcaggtatc gctctccggg gttccatgtg 600 cagtcctggt atgacgaggt gaaggactac acctacccct acccgagcga gtgcaacccc 660 tggtgtccag agaggtgctc ggggcctatg tgcacgcact acacacagat agtttgggcc 720 accaccaaca agatcggttg tgctgtgaac acctgccgga agatgactgt ctggggagaa 780 gtttgggaga acgcggtcta ctttgtctgc aattattctc caaaggggaa ctggattgga 840 gaagccccct acaagaatgg ccggccctgc tctgagtgcc cacccagcta tggaggcagc 900 tgcaggaaca acttgtgtta ccgagaagaa acctacactc caaaacctga aacggacgag 960 atgaatgagg tggaaacggc tcccattcct gaagaaaacc atgtttggct ccaaccgagg 1020 gtgatgagac ccaccaagcc caagaaaacc tctgcggtca actacatgac ccaagtcgtc 1080 agatgtgaca ccaagatgaa ggacaggtgc aaagggtcca cgtgtaacag gtaccagtgc 1140 ccagcaggct gcctgaacca caaggcgaag atctttggaa gtctgttcta tgaaagctcg 1200 tctagcatat gccgcgccgc catccactac gggatcctgg atgacaaggg aggcctggtg 1260 gatatcacca ggaacgggaa ggtccccttc ttcgtgaagt ctgagagaca cggcgtgcag 1320 tccctcagca aatacaaacc ttccagctca ttcatggtgt caaaagtgaa agtgcaggat 1380 ttggactgct acacgaccgt tgctcagctg tgcccgtttg aaaagccagc aactcactgc 1440 ccaagaatcc attgtccggc acactgcaaa gacgaacctt cctactgggc tccggtgttt 1500 ggaaccaaca tctatgcaga tacctcaagc atctgcaaga cagctgtgca cgcgggagtc 1560 atcagcaacg agagtggggg tgacgtggac gtgatgcccg tggataaaaa gaagacctac 1620 gtgggctcgc tcaggaatgg agttcagtct gaaagcctgg ggactcctcg ggatggaaag 1680 gccttccgga tctttgctgt caggcagtga atttccagca ccaggggaga aggggcgtct 1740 tcaggagggc ttcggggttt tgcttttatt tttattttgt cattgcgggg tatatggaga 1800 gtcaggaaac ttcctttgac tgatgttcag tgtccatcac tttgtggcct gtgggtgagg 1860 tgacatctca tcccctcact gaagcaacag catcccaagg tgctcagccg gactccctgg 1920 tgcctgatcc tgctggggcc cgggggtctc catctggacg tcctctctcc tttagagatc 1980 tgagctgtct cttaaagggg acagttgccc aaaatgttcc ttgctatgtg ttcttctgtt 2040 ggtggaggaa gttgatttca acctccctgc caaaagaaca aaccatttga agctcacaat 2100 tgtgaagcat tcacggcgtc ggaagaggcc ttttgagcaa gcgccaatga gtttcaggaa 2160 tgaagtagaa ggtagttatt taaaaataaa aaacacagtc cgtccctacc aatagaggaa 2220 aatggtttta atgtttgctg gtcagacaga caaatgggct agagtaagag ggctgcgggt 2280 atgagagacc ccggctccgc cctggcacgt gtccttgctg gcggcccgcc acaggccccc 2340 ttcaatggcc gcattcagga tggctctata cacagcagtg ctggtttatg tagagttcag 2400 cagtcacttc agagatgtat cttgtctttg tcaggccctt catcttcatg gcccacctgt 2460 tttctgccgt gacctttggt cccattgagg actaaggatc gggacccttt ctttaccccc 2520 tacccgttgt ggctcccacc ctgcctcgga ctggtttacg tgtcctggtt cacacccagg 2580 acttttcttt gcaagcgaac ctgtttgaag cccaagtctt aactcctggt ctcgtaaggt 2640 tccactgaga cgagatgtct gagaacaacc aaagaaggcc tgctctttgc tgcttttaaa 2700 aaatgacaat taaatgtgca gattccccac gcacccgatg acctattttt tcagccgtgg 2760 gaggaatgga gtctttggta cattcctcac cgaggttagc agctcagttt gtggttatga 2820 aaccgtctgt ggcctcatga cagcgagaga tgggaataca ctagaaggat ctcttttcct 2880 gttttcgtga aacgactctt gccaaacgtt cccgaggcgc caaggagtgt agtacaccct 2940 ggctgccatc actctataaa agtgcttcat gagcccagac caaaagccca cagtgaaatg 3000 aagtaccctt ttgtaaatag catttttttg cagaaggtga aaattccact ctctaccacc 3060 gggccagcca atagatcact ttggtgaatg ctagtttcaa atttgattca aaatatttct 3120 taggtgaaag aactagcaga aagtcaaaaa ctaagatact gtagactgga caagaaattc 3180 tacctgggca cctaggtgat gccttctttc tttgattgcc tttctaataa atgcagaatc 3240 tgaaggtaaa taggtttaaa acaaaacaaa aacccacccc tttaaggagt tggtaaaaag 3300 cagttcaact cttagcttga ctgagctaaa attcacagga ctacgtgctt tgtgcattgt 3360 agtctagtcg taattcatag gtactgactc ctcagcccca aatgtcggag aggaagaatt 3420 cggtcagcct gtcaggtcgt gagtccagtt accaccaaac atctgggaaa cttctgggtg 3480 ctgggtgctc tgctgctgga cttttgtggc tgtgtctgtg tctgcaagat aaattagatc 3540 gccctgtggg gtttgcagaa ttagtgaagg gtccaggacg atcccagtgg gctcgcttcc 3600 aaagcatccc actcaaggga gacttgaaac ttccagtgtg agttgacccc atcatttaaa 3660 aataaagtcc ccgggttcct taatgcctcc ttcactgggc cttcctagca ggatagaaag 3720 tccttgccca gagcaggacc tggcnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3900 nnnnnnnnnn catgcccggc catggacctg gctgtcttta tcatccccac aaacattttg 3960 aaactggaat atttgtcttc agaaaatgga aacaagacta taaatgataa gccctgtccc 4020 tagcaccacc tctcctgtgt gtggaataga ggcccctcgt gctaccaaca cttaccctgt 4080 gtttaaaaag atcttgtacc aagccaacgg cgttcctggc tctcctgccc acaggatgaa 4140 cattttcggc ttccttagga gttttgccct accgtattcc aaagcgtgtg ctggtttctc 4200 atattgtctg taggctcact cagcccgcag tttatgtgtg tgcttttttc tatgaaaaat 4260 gatgtatttt gctacttcct gtgtacaaag ttttattgta aatgtttttt gtgctttgca 4320 tgaacagggg ccacgttgtt gcaattgttt cagtagaact ggtttgattt ctaaaatgtt 4380 cctgtaacat atcttttatg aacaaatctg aacaatttgt gaaataaaac attgaaaacc 4440 atcaaaaaat aaattaaaat 4460 <210> 190 <211> 1090 <212> DNA <213> Homo sapiens <400> 190 gtgagctacc tggcccctcc ccaaatttta acatcagatc tcaacatatt tgttgagaac 60 ttgtttagat catcactatc gagtaaattt atgtcagttc tttagagcat ttgcttcaca 120 cacagttcaa ccatttaacc agaaattaaa atatcaccct tttcagccct cccatgaaga 180 atttctaggt cataaacatg aataatactc agtatatgta taatatcata tttaattgtt 240 gcaacttttc ttggcgtgtt taaatcctca tgtctttgag ggatcccacc acaggtgaag 300 gaagtaaaga ccacttctcc cccagtctct gctttctgca gtgctcactc atatcctggc 360 atttagcatg gtgtgttgaa attaggttta cttcttgtct ctccaagtgg ctcctctctt 420 aaaagacaga aactagggtt tagtcatcat ttgtgcttcc tgctagaaac ccacagcctt 480 gaataatggc ttcctgcctc cttgagtcac tttaatatcc ctggtgcata ggacctggca 540 tgcgtcaggc tgctcgggaa atgtgggaac tggacaccca gaacactgct gtgctggggc 600 tatttggggc ctgctgtcag gcagaaagac gttttgaatt gggctttctg cccttgttga 660 gttttctctt aagtaaagtc caaagtccaa ggggcagatg gccagatgca ctgcccagta 720 aggcaggaag ccaaagaggc agtgcccagc cccacaaagg ctgcccgact ccctgggaca 780 gtagtgtgga gtcccagccc aggctgacct cacaccggag cttcctagct tcctttcttt 840 gctcaatgca gggcttcttg caccccctgg aaagctaaga gatttttttc aaccctaaaa 900 gagagtacct ttcactgcat tggatggatg aacatcagtg ccctaacttt atccatcatg 960 taggtcaggg aggactgggc actatttggc aggatgtact ccagaatata atcaaagaat 1020 tttctgtaca tatttcacta aagacaagtt tttgggctgg atgcggtagt tacacctgta 1080 atcccagcac 1090 <210> 191 <211> 11965 <212> DNA <213> Homo sapiens <400> 191 gccgcgcact ctccgcggcg ctgggagagg gcggaggggg aggcggcgcg cggcgccaga 60 ggagggggga cgcagggggc ggagcggaga cagtaccttc ggagataatc ctttctcctg 120 ccgcagagga gaggagcggc cggagcgaga cacttcgccg aggcacagca gccggcagga 180 tggcgaccgt ggtggtggaa gccaccgagc cggagccgtc cggcagcatc gccaacccgg 240 cggcgtccac ctcgcctagc ctgtcgcacc gcttccttga cagcaagttc tacttgctgg 300 tggtcgtcgg cgagatcgtg accgaggagc acctgcggcg tgccatcggc aacatcgagc 360 tcggaatccg atcatgggac acaaacctga ttgaatgcaa cttggaccaa gaactcaaac 420 tttttgtatc tcgacactct gcaagattct ctcctgaagt cccaggacaa aagatccttc 480 atcaccgaag tgacgtttta gaaacagtgg tcctgatcaa cccttctgat gaagcagtca 540 gcaccgaggt gcgcttaatg atcactgatg ctgcccgaca caagctgctc gtgctgaccg 600 ggcagtgctt tgaaaatacc ggagagctca ttctccagtc cggctctttc tccttccaga 660 acttcataga gattttcacc gatcaagaga tcggggagtt actaagcacc acccatcctg 720 ccaacaaagc cagcttaacc ctgttctgtc ctgaagaagg ggactggaag aactccaatc 780 ttgacagaca caatctccaa gacttcatca atattaaact caattcagct tctatcttgc 840 cagaaatgga aggactttct gagtttaccg agtatctctc agaatcagtg gaagtcccat 900 ctccctttga catcttggaa cctcccacat cgggtggatt tctgaagctc tccaagccct 960 gctgttatat ttttccagga gggaggggcg attctgcctt gtttgcagtg aatggtttca 1020 atatgctcat caatggcgga tcagagagaa aatcctgctt ctggaagctc atccgacact 1080 tagaccgagt ggactccatc ctgctcaccc acattgggga tgacaatttg cctggaataa 1140 acagcatgtt acagcggaaa attgcagagc tcgaggaaga acagtcccag ggctccacca 1200 caaatagtga ctggatgaaa aacctcatct cccctgactt aggagttgta tttctcaatg 1260 tacctgaaaa tctcaaaaat ccagagccaa acatcaagat gaagagaagc atagaagaag 1320 cctgcttcac tctccagtac ctaaacaaat tgtccatgaa accagaacct ctgtttagaa 1380 gtgtaggcaa tactattgat cctgtcattc ttttccaaaa aatgggagta ggtaaacttg 1440 agatgtatgt gcttaatcca gtcaagagca gcaaggaaat gcagtatttt atgcagcagt 1500 ggactggtac caacaaagac aaggctgaat tcattctgcc taatggtcaa gaagtagatc 1560 tcccgatttc ctacttaact tcagtctcat ctttgattgt gtggcatcca gcaaaccctg 1620 cggagaaaat catccgagtc ctgtttcctg ggaacagcac ccagtacaac atcctggaag 1680 ggttggaaaa gctcaaacat ctagactttc tgaagcagcc actggccacc caaaaggatc 1740 tcactggcca ggtgcccact cctgtggtga aacaaacaaa actgaaacag agggctgata 1800 gccgagaaag tctgaagcca gccgcaaaac cacttcctag caaatccgtg cgcaaggagt 1860 caaaagaaga aacccctgag gtcacaaaag tgaatcacgt ggaaaagcca cccaaagttg 1920 aaagcaaaga aaaggtaatg gtgaaaaaag acaagccagt aaaaacagag accaaacctt 1980 cagtgactga aaaggaggtt cccagcaaag aagagccatc tccagtgaaa gccgaggtgg 2040 ctgagaagca agccacagat gtcaaaccca aagctgccaa ggagaagacg gtgaaaaagg 2100 aaacaaaggt aaagcctgaa gacaagaaag aggagaaaga aaagccaaag aaagaagtgg 2160 ctaaaaagga ggacaaaaca cctatcaaga aggaggaaaa accaaaaaag gaagaggtga 2220 aaaaagaagt caaaaaagag atcaagaaag aagagaaaaa agaacccaag aaagaggtta 2280 agaaagaaac accgccaaag gaagtcaaga aggaagttaa gaaggaagag aagaaggaag 2340 tgaaaaagga agaaaaggaa cccaaaaaag aaattaagaa gctccctaaa gacgcaaaga 2400 aatcatctac tcctctgtct gaagcaaaaa aaccagctgc tttaaaacca aaagtaccca 2460 agaaggaaga gtctgtcaag aaagattctg ttgctgccgg aaagccaaag gagaagggga 2520 aaataaaagt cattaagaag gaaggcaagg ccgcagaggc tgtcgctgca gctgtcggca 2580 ctggagccac cacagcagct gtcatggcgg cagctggaat agcagccatt ggccctgcca 2640 aagaactcga agctgagagg tcccttatgt catctcctga ggatctaacc aaggactttg 2700 aagagttaaa ggctgaagag gtcgatgtaa caaaggacat caagcctcag ctggagctaa 2760 tcgaagacga agagaaactg aaggaaactg agccagtcga agcctacgtc atccagaagg 2820 agagagaagt caccaaaggt cctgccgagt cccctgatga gggaatcact accactgaag 2880 gggagggcga atgtgaacag acacctgagg agctggagcc cgtcgagaag cagggagtag 2940 acgacattga aaaatttgaa gatgaaggag ccggttttga agaatcttca gagactggag 3000 actatgaaga gaaggcagaa actgaggagg ctgaggagcc agaagaggat ggggaggaac 3060 acgtatgtgt gagcgcctcc aagcacagcc ccactgagga tgaggaaagt gccaaggcgg 3120 aggctgatgc atacatcagg gagaagaggg agtctgtggc cagtggggat gaccgagccg 3180 aagaagacat ggatgaggcc attgagaaag gagaggctga acaatctgaa gaggaggctg 3240 atgaggagga caaagctgaa gatgccagag aggaggaata tgagccggaa aaaatggaag 3300 ctgaagacta tgtgatggct gtggtcgaca aggctgcaga ggctggtggt gccgaggagc 3360 agtatggatt cctcaccaca ccaaccaagc aactaggagc ccagtctcct ggccgagaac 3420 ctgcatcttc aattcatgat gagactttac ctggaggctc agagagcgag gccaccgctt 3480 ctgatgagga gaatcgagaa gaccagcctg aggaattcac tgccacctct ggctacactc 3540 agtctactat tgagatatcc agtgagccca cccccatgga tgagatgtct acccctcgag 3600 acgtgatgag tgatgagacc aacaatgaag agacggagtc cccttctcag gaattcgtaa 3660 atatcaccaa atatgaatct tcattgtatt ctcaggaata ctctaaacct gctgatgtta 3720 caccgctcaa cggattttct gaaggatcaa aaacagatgc cactgatggc aaggattaca 3780 atgcttcagc ctctaccata tcaccaccct cttccatgga ggaagacaaa ttcagcagat 3840 ctgctttacg tgatgcttac tgctctgaag tgaaagccag caccactttg gacatcaaag 3900 atagcatctc agctgtttca agtgaaaagg tcagcccatc gaagagcccg tccctgagtc 3960 catctccacc atcaccctta gaaaagaccc ccctgggtga acgtagtgtg aacttctctc 4020 tgacgcccaa tgagattaaa gtctctgcag aggcagaagt agccccggtg tctcctgagg 4080 tgacccaaga agtagttgaa gaacattgtg ctagtcctga ggacaagact ctggaagtgg 4140 tgtcaccatc tcagtccgtg actggcagtg ctggtcacac accttactat caatctccta 4200 ctgacgagaa atccagtcat ctccctacag aagtcattga aaaaccacca gcagttccag 4260 tgagttttga attcagtgat gccaaagatg agaatgaaag ggcttcagta agccccatgg 4320 atgagcccgt gcctgactca gagtctccta ttgaaaaagt tttgtctcct ttacgcagcc 4380 cgcccctcat tggatccgag tctgcttatg aaagttttct aagtgctgat gacaaggctt 4440 ctggcagagg tgccgaaagt ccttttgaag aaaagagtgg aaaacaaggc tctccagacc 4500 aagtaagtcc agtttctgaa atgacttcta ctagtcttta ccaagacaaa caggaaggga 4560 aaagcacaga ctttgcacca ataaaagaag actttggcca agaaaagaaa actgatgatg 4620 ttgaagccat gagttctcaa ccagcactgg ctctggatga aaggaaatta ggagatgttt 4680 ctcccacaca aatagatgtc agtcagtttg gatcttttaa agaagacact aagatgtcca 4740 tttctgaagg tactgtctca gacaagtcag ctactcctgt tgatgagggc gtagcagaag 4800 acacgtactc tcatatggag ggtgtggcct cagtgtccac agcctcagtg gctacgagct 4860 catttccaga gccaacaaca gatgatgtgt ctccatctct gcatgctgag gttggctccc 4920 cacattccac agaagtagat gactcccttt cagtgtctgt tgtgcaaaca cctaccacat 4980 tccaggaaac agaaatgtct ccatctaaag aagaatgccc aagaccgatg tcaatttctc 5040 caccagattt ctcccctaaa actgcaaagt ccaggacacc cgttcaagat cacagatctg 5100 aacagtcctc aatgtctatt gaatttggcc aagaatctcc tgagcaatcc cttgctatgg 5160 acttcagtcg acagtctcca gatcacccta cagtgggtgc aggcgtgctt cacatcactg 5220 aaaatgggcc aactgaagtg gactacagtc cttctgacat gcaggactcc agtttatcac 5280 ataagatacc acctatggag gagccgtcct acacccaaga taatgatctt tctgagctca 5340 tctcagtatc tcaggtagag gcctccccgt ccacctcttc tgctcatacc ccttctcaga 5400 tcgcttctcc tctccaagaa gatactctat ccgatgttgc tcctcccaga gatatgtcct 5460 tatatgcctc actcacctct gaaaaagtgc aaagtctgga aggagagaag ctctctccaa 5520 aatctgatat ctctccactc accccacgag agtcctctcc tttatattca cctacttttt 5580 cagattctac ctctgcagtc aaagagaaaa cagcaacttg ccacagttcc tcttctccac 5640 caatagatgc agcatccgca gagccctatg gcttccgtgc ctcagtgtta ttcgatacaa 5700 tgcaacacca tctagccttg aatagagatt tgtccacacc tggcctggag aaggacagtg 5760 gagggaagac acctggtgac tttagctatg cctatcaaaa gcctgaggaa acaaccaggt 5820 ccccagatga agaagattat gactatgagt cttatgagaa gaccacccgg acctcagatg 5880 tgggtggcta ttactatgag aagatagaga gaaccacaaa atctccaagt gacagtggct 5940 actcctatga gaccattggg aaaactacca agacccctga agatggtgac tattcctatg 6000 aaattattga gaagaccaca cggacccctg aagagggtgg gtactcatat gacataagtg 6060 aaaagaccac cagccccccc gaagtgagtg gttacagcta tgaaaagact gagaggtcta 6120 gaaggcttct ggatgacatc agcaatggct atgatgactc tgaggatggt ggccacacac 6180 ttggggaccc cagctactct tatgaaacca ctgagaaaat taccagtttc cctgagtctg 6240 aaggttattc ctatgagaca tctacaaaga caacacgaac ccctgatact tccacatact 6300 gttacgagac tgcagagaaa atcactagaa cccctcaggc atccacatat tcctacgaga 6360 cttcagacct atgctacact gcagaaaaga agtccccctc agaagcccgt caggatgtcg 6420 atttatgcct cgtgtcctct tgtgaataca agcaccccaa gacagagctt tcaccctctt 6480 tcattaatcc caatcctctt gagtggtttg ccagtgaaga acccactgaa gaatctgaaa 6540 agcccctcac tcaatcaggg ggagccccac cgcctccagg aggaaagcaa cagggccgac 6600 agtgtgatga aacccctccc acctcagtca gcgagtcagc cccatcccag accgactctg 6660 atgttccccc ggagactgaa gagtgcccct ccatcacggc cgatgccaat atcgactctg 6720 aagacgagtc ggaaaccatc cccacagaca aaactgtcac gtacaaacac atggacccac 6780 ctccagctcc cgtgcaagac cgcagccctt cgccacgcca ccctgatgtg tccatggtgg 6840 acccagaggc cttggccatt gagcagaacc tgggcaaagc tctaaagaaa gatctgaaag 6900 agaagaccaa aaccaaaaag ccaggtacaa agaccaagtc atcttcacct gtcaaaaaga 6960 gtgatgggaa gtctaagccc ttggcagctt caccaaaacc agcgggcttg aaagaatcct 7020 cggataaagt gtccagggtg gcttctccta agaagaaaga atctgtggaa aaggcagcaa 7080 aacccaccac cactcctgag gtcaaagctg cacgtgggga agagaaagac aaggagacca 7140 agaatgctgc caatgcctct gcatccaagt cggccaagac cgccactgca ggaccaggaa 7200 ctaccaagac gaccaagtca tctgctgtgc ccccaggcct ccctgtgtat ttggacctgt 7260 gctacattcc taaccacagc aatagtaaga atgttgatgt ggaatttttc aagagagtgc 7320 ggtcttccta ctacgtggtg agtgggaatg accctgctgc tgaggagccc agccgggctg 7380 tcctggacgc tttgttggaa ggaaaggctc agtggggcag caacatgcag gtgacactga 7440 tcccaactca tgactcagaa gtgatgaggg aatggtacca ggagacccat gagaaacagc 7500 aagatctcaa catcatggtt ttagcaagca gcagcacagt ggttatgcaa gatgaatcct 7560 tccctgcatg caagattgaa ctgtaaaaac caaggccagc cacaccacag gatctgaact 7620 ttgtttccag aaattcttca atttgaaatc accttttcta aaaagtcaat tcatctagtt 7680 aagtcgctga acaattacct gccaaatgct atactgtgtc atggtgatgc aagtcactaa 7740 atttctcagt ttttgctgat tgctaaggga aataacagta tttccacaat agggttcaaa 7800 ttcctgcaaa attacctacc ccagttcatc tctgctgaac atttggaaac catgcactag 7860 ccaacccaac tgacttctgc taggtagagg catttgtctt agagagagag agagcgcggg 7920 agagagtgag agagagctga gagcacaaag ataacgcagg tgagagagag agaaagaatg 7980 aggaaagaaa aggaatgcaa gagaaggaga tgtaatgaca gagagttctg gtgagatacc 8040 cagagagaaa aagagagagc agggtggggt aaggaggaga aaataaacca acaattaggt 8100 ctgcattttc tcaggcagta ggcattcttt agtctacata ggcaaagttt tccatttttg 8160 tcagtctgag tcatcaaaaa gagtcttaat tttctaaaac aagttggcta gaagaaagta 8220 aaaagaacaa cacttgttat gagggcatgt gatattttca catcttaatt aagctccttc 8280 agtttgaagg ctgcacactg acataatgta gtgagtgtag actggccatg caagtggttt 8340 gggccccatt cagaactctc agactctaaa cacacaagta gattgatcta aggcatgctc 8400 ccagcatttg tccacccact tagtccactc tgagtcgatt aacctgcatg cagcaacacc 8460 caagtccacc ccaattaact gaagcaaata ccaaagcagt tgggagtaca tatggtagac 8520 aatttgcctt aggaagtgac ttgaatgtac aaagatactt gatgcactta ttttttaatg 8580 tgagacagca agtttataaa acatccatat aggattatag atacttaaag gaacacgtgg 8640 gtgagcgtgt gtgggggtac tagaagctga tctgattggt ccaacagttt gatgctgagt 8700 catgcgtgtt gaatcccact tcagtgcacc tgtggcctct cagtcaaaca agttgtgcct 8760 ttcacagctt ctttactact gcaagttcaa gactgaaatg gcttctatga tcagaactgg 8820 gaaaacagtg aatcttatgg tggaagaggt tctcagcaag tgtacagtat ttaccttcct 8880 ttgtcttaca ttggcttttt aaattttcca ttaatttcaa cataattatg ggaacaagtg 8940 tacagaagaa tttttttttt aagatatgtg agaacttttc atagatgaac tttttaacaa 9000 atgttttcat ttacaggaaa ttgcaaagaa aattctcaag tgatagtctt ttttttttaa 9060 gtgtttcgta agacaaaaat tgaataatgt tttttgaagt tctggcaaga ttgaagtctg 9120 atattgcagt aatgatattt attaaaaacc cataactacc aggaataatg atacctccca 9180 ccccttgatt cccataacat aaaagtgcta cttgagagtg ggggagaatg gcatggtagg 9240 ctacttttca gggccttgac aagtacatca cccagtggta tcctacatac ttctttcaag 9300 atcttcaacc atgaggtaaa agagccaagt tcaaagaacc ctagcacaaa tttgctttgg 9360 gattttcttt tctggaaaaa aaaaataaaa gaaatagtac attgaaaaca aatgaattct 9420 caactcctac ggttcatgta gagtttagag aaaatttcca tcattgtcat cattgaactg 9480 tgaacctggg aagccagatc atgattaaca ctgacatcaa gtttcaagtt gcagatcaat 9540 gcacccagtg ttcagatgag gcaaacttct ccgtgacaac tgtgctgtgc tctgtcacat 9600 tacatttcct gcagactcta agatctacgg agtagagaac aatgacctca ttttattttc 9660 tatgttagtt atttatttca aaattaacat tttagttgat ttttgtctga taagtctatg 9720 ttttgcactg ctaactatga tgagggttta aaaaaatgct tcttcagggt cctttcactg 9780 aggacctatg cagtctactt aatgctgtga attacatttt tcaaatgttt aattttttaa 9840 agaaaattaa tattctattt ttgttaggct tctctagaaa tgcagctttt atttattacc 9900 ccatttcttt caagtccttg gaaaataaca tattaagggt acaagaaatt aacacatgat 9960 ggaaaagtca ttgtgacgcc aatgaatttc attgagtata aactcatcta cttcaaattt 10020 attttataag acaacctaag atactcaaga taattattta atggttagct cttaagttga 10080 attggtctac ataatgcgtg ggaagaaaac cagattttta gccttcttgc caaatccaga 10140 cctctggttg atttttcttt gacagaagat gcaagttatt ttccaatttc acaattaaat 10200 gtatttaaca tgaacattat tttgctttaa aaactataaa cattgtagga gaattatagc 10260 cagtcttcag ttataaccac tccaccctcc tcactttctg ctctctctct ctcttttttt 10320 tttgctatgg gatttaatgg gaaaaatatg taaaaactgt cactagtcag ctggctcttt 10380 ttcctatgaa atctatcagt acctttctcc atccgttgtt ctcaataatg accacagagc 10440 ctgagtatac caagaaaacc aatattcgca ttacaggttg ctcctgtcct tccagacacc 10500 tttcctgcct gtgtgactaa cctaattttg ctagttccat aaatacacga ttagtttagt 10560 aacagccatc acaatgtacc atgtacattc atggtgagag ctaaagatcg acacagactt 10620 ctaggagctt tgttcatact gattacttaa tccaattgta tagattgaat atttgagtgg 10680 aaggaattta cactctgttt aaatgatggg attctatcga gatagcactc atgatcatga 10740 cctttttggt agtattctta aacaaaattc tacagagact aaatgttagc gatgatcctc 10800 cattttcaat tttaaccaat tctgtcccct ttctcaaaac cctgagccct gtgcatgctt 10860 tctcagtctt gtggtgggac tggatacaat gactaacttc ccctcctccc ctctttaaac 10920 accattttcc atggagttca aaaaattttt tttcttaacg ttacatatca tagtgaatgg 10980 tttccccagt gtatatgaat gttttaagtg tctccaatag cttatgcagt ctaggagctt 11040 tccaatactc atttaattaa gatttaatca tttgctaatg gaaatcttac cacctttcat 11100 tttccctctg ttaccaaatt tcagctctta ggagctgctc tacaattctg aatttgcttt 11160 tcttgcctct ctttagtcac ctgtcacagg aggttcctgc tcagtaatga tattgtgagt 11220 taggataata actttttttt tttgtgcttc agatttagaa gaaaagatcc tgtttccatt 11280 tgaaaggaac tgtaagcttt tatcttttaa ccaactgaac aatacaccaa aagcagccta 11340 gggatgagca tttctttgaa agcaattagg ttattcacct ggtattaaaa ctatttactg 11400 ttaaaaaatc tgtgacttca tgaagttgat ttttaaaggc agcatcaaaa actgaaaagg 11460 aagggaaaaa ataggcagct tctctgcact tgtttggagc tccccaaaac aggagccatg 11520 gagaagtggc atcaagaccg ggctgccctt tcgagaacac cctgtggcag ttcagagaca 11580 cgcttttcct acactgcatg cagcccctct ttccagcact ggaaagaagt ggtcttgagc 11640 ccagctgaga agcacttcac actcctctct cttgttctga atggtgtttg tgtcagtctg 11700 cagctgtgta tggtattatg tcttataatc ctgcatcact tctatcctat ccagtcatat 11760 ctaatgtaga aaattagttt ccagtgaaag taatatgtag tgcttttatg atatttgtgt 11820 gcaatatccc ctcttccatt gaggatattt gatgtaaagg aaaaaaaaaa actcagttcc 11880 acaataaaat acaaaagtgg caaaaaaaat ctatgtcggg tgcggagaaa gaggtaatga 11940 aatggcagga attcgatatc agcta 11965 <210> 192 <211> 2909 <212> DNA <213> Homo sapiens <400> 192 cgaattggcc gctgcgcctc ctcccgaggc atgctgggag cctggaggac tagcgaggag 60 gagttgagag aacggagcgg acgccatggc gaccaacatc gagcagattt ttaggtcttt 120 cgtggtcagt aaattccggg aaattcaaca ggagctttcc agtggaagga atgaaggcca 180 gctgaatggt gaaacaaata cacccattga aggaaaccag gcgggtgatg cagctgcctc 240 tgccaggagt ctaccaaatg aagaaatagt gcagaagata gaggaagtac tttctggggt 300 cttagataca gaactacgat ataagccaga cttgaaagag ggctccagaa aaagtagatg 360 cgtatctgta caaacagatc ctactgatga aattcccact aaaaagtcaa agaagcataa 420 aaagcacaaa aacaaaaaga agaaaaagaa gaaagaaaag gaaaaaaaat ataaaagaca 480 gccagaagaa tctgagtcaa agacgaaatc tcatgatgat gggaacatag atttagaatc 540 tgattccttt ttaaagtttg attctgaacc ttcagctgtg gcgctggagc ttcctacaag 600 agcatttggc ccatctgaga ccaatgaatc ccctgcagtt gtgctagaac ctcctgtagt 660 atcaatggag gtatcagagc cacacatctt agaaactctg aagccagcta caaaaactgc 720 agaactgtca gttgtatcta catcagtaat ctcagagcag tcagagcagt ctgtggcagt 780 aatgccagaa ccatccatga caaagattct ggattccttt gcagcagcac cagtgcctac 840 tacaacactg gtgttgaagt catctgagcc agttgtaaca atgtcagtgg agtatcagat 900 gaagtctgtg ctgaaatctg tggagagcac atctccagag ccatcaaaga tcatgttggt 960 agagccccca gtagcaaaag tgttagagcc ttcagaaacc cttgtggtat catcagagac 1020 acctactgag gtgtaccctg agccaagcac atcaacaaca atggattttc cagagtcatc 1080 tgcaattgaa gcgctaagat tgccagagca gcctgtagac gtaccatcgg agattgcaga 1140 ttcatccatg acaagaccgc aggagttgcc ggagctgcct aagaccacag cgttggagct 1200 gcaggagtcg tcggtggcct cagcgatgga gttgccgggg ccacctgcga cctccatgcc 1260 ggagttgcag gggccccctg tgactccagt gctggagtta cctgggccct ctgctacccc 1320 ggtgccagag ttgccagggc ccctttctac cccagtgcct gagttgccag ggccccctgc 1380 gacagcagtg cctgagttgc cagggccctc tgtggcgctg gagatctctg ttcagtctgt 1440 ggtgacaaca tcggagctgt caacgatgac cgtgtcgcag tccctggagg tgccctcgac 1500 gacagcgctg gaatcctata atacggtagc acaggagctg cctactacat tagtggggga 1560 gacttctgta acagtaggag tggatccctt gatggcccca gaatcccata tattagcttc 1620 taacaccatg gagacccata tattagcatc caacaccatg gactcccaaa tgctagcgtc 1680 caacaccatg gactcccaga tgctagcatc caacaccatg gactcccaga tgttagcgtc 1740 tagcaccatg gactcccaga tgttagcaac tagctccatg gactcccaaa tgctagcgtc 1800 caacaccatg gactcccaga tgctagcatc caacaccatg gactcccaga tgttagcgtc 1860 tagcaccatg gactcccaga tgttagcaac tagctccatg gactcccaga tgttagcaac 1920 tagctccatg gactcccaga tgttagcaac tagcactatg gactcccaga tgttagcaac 1980 cagttccatg gactcccaga tgttagcaac cagctccatg gactcccaga tgttagcaac 2040 cagctccatg gactcccaga tgttagcaac cagctccatg gactcccaga tgttagcaac 2100 cagcaccatg gattctcaga tgttagcaac cagcaccatg gactcccaga tgttagcaac 2160 tagctcaatg gattcccaga tgttagcatc tggcactatg gactctcaaa tgttagcttc 2220 tggcaccatg gatgctcaga tgttagcgtc tggtaccatg gatgcccaga tgttagcgtc 2280 tagtacccaa gattctgcta tgttgggttc aaaatctcct gatccctata ggttagctca 2340 ggatccttac aggttagctc aggatcccta taggttgggc catgacccct atagattagg 2400 tcatgatgct tacaggttag gacaagaccc ttatagatta ggccatgatc cctacagact 2460 aactcctgat ccctatagga tgtcacctag accctacagg atagcaccca ggtcctatag 2520 aatagcaccc aggccatata ggttagcacc tagacccctg atgttagcat ctagacgttc 2580 tatgatgatg tcctatgctg cagaacgttc catgatgtca tcttacgaac gctctatgat 2640 gtcttatgag cggtctatga tgtcccctat ggctgaacgc tctatgatgt cagcctacga 2700 gcgctctatg atgtcagcct acgagcgctc tatgatgtcc cctatggctg agcgctctat 2760 gatgtcagct tatgaacgct ccatgatgtc agcttatgaa cgctccatga tgtccccaat 2820 ggctgatcga tctatgatgt ccatgggtgc tgaccggtct atgatgtcgt catactctgc 2880 tgctgaccgg tctatgatgt aatcgaact 2909 <210> 193 <211> 2803 <212> DNA <213> Homo sapiens <400> 193 tgttctaagg ccaggagcac ggtgagccac agtctgttgg ctagaatttg gcgtcttgat 60 agttgagaaa atggcgatga cactcgttgg aagactggtg ccgggggatg gatgtgaact 120 cccagagagc tctgttagtc tggggcatcc cagtgaactg tgatgaggct gaaatcgaag 180 agaccctcca ggctgcgatg ccccaggtct cctaccgaat gcttgggaga atgttctgga 240 gggaagaaaa tgcgaaagca gccttattag agctcactgg cgctgtagat tacgccgcga 300 tccccaggga gatgccgggc aaaggagggg tctggaaagt gttatttaag cccccaactt 360 ctgatgctga atttttagaa agattgcacc tctccctctg gctagtctcc caaacggccg 420 ctcctcgccc gcgggaagac caggctgcga ccgcgaacgc ccgatcctct ccaggagccg 480 cagcgagcgc ccggcggcca cgccccgcga ccacaccccg gcggctctcg gcccagcgcg 540 cctgccttcg ccgcccgccg tcgctcctcg cccgctgcac gacgacgcga cgcccctgct 600 gcaggcggcg gacccgaccg gacccagacc cagacgcaag atggcgacgg ccgcgtgact 660 gcctcagcgt ccccgagctc ggctccgagt gcacctacgg actgactgtg ggggcagaga 720 agggcgagat caggactctg tctttgttaa tcgtgactgc atgaaggtcg cctccctcgg 780 gcctacttgg tgggagtgtc tggtattgtt ctaaggccag gagcacggtg agccacagtc 840 tgttggtaga atttggcgtc ttgatagttg agaaaatggc gatgacactg ttggaagact 900 ggtgccgggg gatggatgtg aactcccaga gagctctgtt agtctggggc atcccagtga 960 actgtgatga ggctgaaatc gaagagaccc tccaggctgc gatgccccag gtctcctacc 1020 gaatgcttgg gagaatgttc tggagggaag aaaatgcgaa agcagcctta ttagagctca 1080 ctggcgctgt agattacgcc gcgatcccca gggagatgcc gggcaaagga ggggtctgga 1140 aagtgttatt taagccccca acttctgatg ctgaattttt agaaagattg cacctcttcc 1200 tagctagaga ggggtggacc gtgcaagatg ttgcccgtgt ccttgggttt cagaacccta 1260 ctccgacccc gggcccagag atgccagcag agatgctaaa ctatattttg gataatgtta 1320 ttcagcctct tgttgagtcc atatggtaca agaggctgac acttttctcg gggagggaca 1380 tcccagggcc tggagaggaa acctttgatc cctggctgga gcacactaat gaggtcctag 1440 aggagtggca ggtgtccgat gtagaaaaga ggcggcggtt gatggagagt cttagaggcc 1500 ccgccgctga tgttattcgc atccttaagt ccaacaaccc cgcgataacc actgccgaat 1560 gcctgaaggc gcttgagcag gtgtttggga gcgttgagag ctctagggat gcccagatca 1620 aatttctgaa cacttatcag aacccgggag aaaaattgtc tgcttatgtc attcgtctgg 1680 agcctctgct acagaaggtg gtagagaagg gggccattga taaagataat gtgaaccagg 1740 cccgcctaga gcaggtcatt gccggggcca accacagcgg ggccatccga aggcagctgt 1800 ggcttaccgg ggctggggaa gggccagccc caaacctctt tcagttgctg gtgcagatcc 1860 gtgaggagga agccaaggag gaggaggagg aggctgaggc cacccttctg cagttaggcc 1920 tggaagggca cttctgagtg ccaggaaagg cagctttagt gcagacctag atcacagcta 1980 cttttcttgt ccctgtgggg tcttacagat gtgtctctga gtagtaaagg cttagccttg 2040 ttctgttttg ttgttttttg gaggggaagg ttagtcaggc ctgagtattc atgtaacatt 2100 ctaaaattgt gccagcgagc accgtgaacg actgcaatgc aagcgggtct tgctggctaa 2160 aatgccaggt aaagggttgg ttggacacag cgcttagtgc acgctgtcat catggacatc 2220 ataatcagtt gtgaaaaaca cgcgaaccta tgacacttct tattccacac tgaatgtgaa 2280 attgcatgtt cagatgttta ctacgaggcc tggctcacag gaagtgttca gtaaaagtat 2340 gcactgttag attactgata acgcggatag atttttgttt accataaatt gttccagatt 2400 tatattaatg gaaggaagtg tgcatttatt agctattact caactttaca atgcaaacat 2460 cttatttctc atctttaaac atgtcgacca gtttaattga aaagtattct gagactgcaa 2520 aatggggtgt taaaaaatac tgcagttacg gagctgtgta aaccagtttc tcattgcata 2580 agatacagat gtaaattgca tggagaggtt gatatgcacc tgtacagtaa ttcactcccc 2640 catttcacat ctttgtcaga gaatagttct tgttcatact gagtgttcta aatttgaagt 2700 tatatataca aattaaaata ttttaaaaat taaaaaaaat ctatgtcggg tgcggagaaa 2760 gaggtaatga aatggcagga attcgataat caagcttatc gat 2803 <210> 194 <211> 1459 <212> DNA <213> Homo sapiens <400> 194 ttccgaaagc ggagtggcgc tccggccagt gattggctgg aggtttgtta actattcatg 60 agggggcggg ccgagcgggg cggcctttgt taagcagcga gggcgcgacc gcgggtactc 120 tgctgccggc ttctcggagc ggcgctgggc gaccagagca gggtcgagat gtcctacatc 180 ccgggccagc cggtcaccgc cgtggtgcaa agagttgaaa ttcacaagct gcgtcaaggt 240 gagaacttaa tcctgggttt cagcattgga ggtggaatcg accaggaccc ttcccagaat 300 cccttctctg aagacaagac ggacaagggt atttatgtca cacgggtgtc tgaaggaggc 360 cctgctgaaa tcgctgggct gcagattgga gacaagatca tgcaggtgaa cggctgggac 420 atgaccatgg tcacacacga ccaggcccgc aagcggctca ccaagcgctc ggaggaggtg 480 gtgcgtctgc tggtgacgcg gcagtcgctg cagaaggccg tgcagcagtc catgctgtcc 540 tagcagccac caccatctgc gactcctgcc tgccgcctct ctgtacagta acgccacttc 600 cacactctgt ccccatctgg cttctgctga ccgctgggcc ccagctcaga agggctatag 660 ctggtcccag aggcctggcc tggccttcct tcccttctcc catccctggc ctggggcctc 720 tgggaccagc tttctctcct ggacaccgag gattggaaat aagggcctgg agctgagtag 780 tagccagtct gctgtgacca caggctcagg tccgaccctg ctgcttggcc acagcagtgg 840 ctgggcaagt gggaaccact atctcttggg agcccccaaa agctgggaaa tgctggagga 900 accaggcctt tcccgctttt gcctggctgc agggttcggc tccgcccctg ccccccagcc 960 ctcgtgtgtc cacaccgcag tgcctctgcc cctcggggga ctggacacac atcctgccag 1020 aggcgctacg aagctttgcc cagatgaagc caggtgggct ccgcgttcac tcccactctc 1080 ccgaggggtg ctggcctccc cagggtttgc cttcttacgg atttagacga ggttcgaggc 1140 tcacctatca gggcagctct caggattgtc attttcctct ttgcctgtgg gtttaacttt 1200 tgtatttttt taatcacaag tttgatacaa aatgttttta tcgtactctt tggagatgcc 1260 cattctactt ttgaatttag cttttactaa ttcgcatctg gaagctcagc aagtgcacaa 1320 gccttacttt ggttaccgtg gaaaccactg ccgcccctcc ccgatgtggt gcgctcaata 1380 aaaatgctgg aattcaaaaa aatctatgtc ggtgcggaga aagaggtaat gaaatggcag 1440 gaattcgata tcagcttat 1459 <210> 195 <211> 1696 <212> DNA <213> Homo sapiens <400> 195 gtggaaatgt ccaggccagc agtaccactt ctgaactcca acaacgagaa aatgtcagat 60 cccaatatgg aagctaacag tcattacggt cacaatgacg atgtcagaaa ccatgcaatg 120 gaaaccaata aatgataata aagagcctct gaactcagac gtgcagtaca cggaagttca 180 agtgtcctca gctgagtctc acaaagatct aggaaagaag gacacagaga cagtgtacag 240 tgaagtccgg aaagctgtcc ctgatgccgt ggaaagcaga tactctagaa cggaaggctc 300 ccttgatgga acttagacag caaggccaga tgcacatccc tggaaggaca tccatgttcc 360 gagaagaaca gataatccct gtatttcaag acctctgtgc acttatttat gaacctgccc 420 tgctcccaca gaacacagca attcctcagg ctaagctgcc ggttcttaaa tccatcctgc 480 taagttaatg ttgggtagaa agagatacag aggggctgtt gaatttccca cataccctcc 540 ttccaccaag ttggaacatc cttggaaatt ggaagagcac aagaggagat ccagggcaag 600 gccattggga tattctgaaa cttgaatatt ttgttttgtg cagagataaa gaccttttcc 660 atgcaccctc atacacagaa accaattttc ttttttatac tcaatcattt ctagcgcatg 720 gcctggttag aggctggttt tttctctttt cctttggtcc ttcaaaggct tgtagttttg 780 ggtagtcctt gttctttgga aatacacagt gctgaccaga cagcctcccc ctgtcccctc 840 tatgacctcg ccctccacaa atgggaaaac cagactactt gggagcaccg cctgtgaaat 900 accaacctga agacacggtt cattcaggca acgcacaaaa cagaaaatga aggtggaaca 960 agcacagatg ttcttcaact gtttttgtct acactctttc tcttttcctc taccatgctg 1020 aaggctgaaa gacaggaaga tggtgccatc agcaaatatt attcttaatt gaaaacttga 1080 aatgtgtatg tttcttacta atttttaaaa atgtattcct tgccannnnn nnnnnnnnnn 1140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1200 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1320 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tgcttgctaa agaagtggtc 1440 tcctgaggtc ttaagacatt cctgacagtg tcttgagtgg gtgggagaga ggttgctgtc 1500 attgcgctgt ggaatttcac agatgagaac cacgcctagc caaaatcact tttcctgttt 1560 gcctcagtga cacagctgca gggaccctcg tggatgttgt attaaataaa tttgaccttt 1620 actctttgca acatccacga gtgcccttgc tgcacccaga ccaccggcca ggagagacct 1680 tatctcccac tccacc 1696 <210> 196 <211> 5387 <212> DNA <213> Homo sapiens <400> 196 atttggtaat gctgcacaga aattttcaat tggagattcc acagtaagcg ttttttttct 60 ttgaagattt atgatgcact tattcaatag ctgtcagccg ttccaccctt ttgaccgtac 120 acattctatt acaatgaatt ttgcagtttt gcacattttt taaatgtcat taactgttag 180 ggaattttac ttgaatactg aatacatata atgtttatat taaaaaggac atttgtgtta 240 aaaaggaaat tagagttgca gtaaactttc aatgctgcac acaaaaaaaa gacatttgat 300 ttttcagtag aaattgtcct acatgtgctt tattgatttg ctattgaaag aatagggttt 360 tttgnnnnnn nnnnnnnnnn nnnnnnnnta aatgtgcagt gttgaatcat ttcttcatag 420 tgctcccccg agttgggact agggcttcaa tttcacttct taaaaaaaat catcatatat 480 ttgatatgcc cagactgcat acgattttaa gcggagtaca actactattg taaagctaat 540 gtgaagatat tattaaaaag gttttttttt ccagaaattt ggtgtcttca aattatacct 600 tcaccttgac atttgaatat ccagccattt tgtttcttaa tggtataaaa ttccattttc 660 aataacttat tggtgctgaa attgttcact agctgtggtc tgacctagtt aatttacaaa 720 tacagattga ataggaccta ctagagcagc atttatagag tttgatggca aatagattag 780 gcagaacttc atctaaaata ttcttagtaa ataatgttga cacgttttcc ataccttgtc 840 agtttcattc aacaattttt aaatttttaa caaagctctt aggatttaca catttatatt 900 taaacattga tatatagagt attgattgat tgctcataag ttaaattggt aaagttagag 960 acaactattc taacacctca ccattgaaat ttatatgcca ccttgtcttt cataaaagct 1020 gaaaattgtt acctaaaatg aaaatcaact tcatgttttg aagatagtta taaatattgt 1080 tctttgttac aatttcgggc accgcatatt aaaacgtaac tttattgttc caatatgtaa 1140 catggagggc caggtcataa ataatgacat tataatgggc ttttgcactg ttattatttt 1200 tcctttggaa tgtgaaggtc tgaatgaggg ttttgatttt gaatgtttca atgtttttga 1260 gaagccttgc ttacatttta tggtgtagtc attggaaatg gaaaaatggc attatatata 1320 ttatatatat aaatatatat tatacatact ctccttactt tatttcagtt accatcccca 1380 tagaatttga caagaattgc tatgactgaa aggttttcga gtcctaatta aaactttatt 1440 tatggcagta ttcataatta gcctgaaatg cattctgtag gtaatctctg agtttctgga 1500 atattttctt agactttttg gatgtgcagc agcttacatg tctgaagtta cttgaaggca 1560 tcacttttaa gaaagcttac agttgggccc tgtaccatcc caagtccttt gtagctcctc 1620 ttgaacatgt ttgccatact tttaaaaggg tagttgaata aatagcatca ccattctttg 1680 ctgtggcaca ggttataaac ttaagtggag tttaccggca gcatcaaatg tttcagcttt 1740 aaaaaataaa agtagggtac aagtttaatg tttagttcta gaaattttgt gcaatatgtt 1800 cataacgatg gctgtggttg ccacaaagtg cctcgtttac ctttaaatac tgttaatgtg 1860 tcatgcatgc agatggaagg ggtggaactg tgcactaaag tgggggcttt aactgtagta 1920 tttggcagag ttgccttcta cctgccagtt caaaagttca acctgttttc atatagaata 1980 tatatactaa aaaatttcag tctgttaaac agccttactc tgattcagcc tcttcagata 2040 ctcttgtgct gtgcagcagt ggctctgtgt gtaaatgcta tgcactgagg atacacaaaa 2100 ataccaatat gatgtgtaca ggataatgcc tcatcccaat cagatgtcca tttgttattg 2160 tgtttgttaa caacccttta tctcttagtg ttataaactc cacttaaaac tgattaaagt 2220 ctcattcttg tcattgtgtg ggtgttttat taaatgagag tttataattc aaattgctta 2280 agtccattga agttttaatt aatgggcagc caaatgtgaa tacaaagttt tcagtttttt 2340 tttttcctgc tgtccttcaa agcctacnnn nnnnnnnnnn nnnnnnnnnn nnnnntggcc 2400 tgagagtaga gtatctgtct actcatgttt aattaaggaa aaacacttat ttttagggct 2460 ttagtcatca cttcataaat tgtataagca cattaaatag cgttctagtc ctgaaaaagt 2520 ccaagattct tagaaaattg tgcatatttt tattatgaca gatgtttgaa gataattccc 2580 cagaatggat ttgatacttt agatttcaat tttgtggctt ttgtctatta ttctgtactc 2640 tgccatcagc atatggaaag cttcatttac tcatcatgac ttgtgccata taaaaattga 2700 tatttcggaa tagtctaaag gactttttgt acttgaattt aatcatgttg tttctaatat 2760 tcttaaaagc ttgaagacta aagcatatcc tttcaacaaa gcatagtaag gtaataagaa 2820 agtgtagttt gtacaagtgt taaaaaaata aagtagacaa tgttacagtg ggacttatta 2880 tttcaagttt acattttctc catgtaattt tttaaaaagt aaatgaaaaa atgtgcaata 2940 atgtaaaata tgaagtgtat gtgtacacac attttatttt tcggtatctt gggtatacgt 3000 atggttgaaa actatactgg agtctaaaag tattctaatt tataagaaga cattttggtg 3060 atgtttgaaa aatagaaatg tgctagtttt gtttttatat catgtccttt gtacgttgta 3120 atatgagctg gcttggttca gtaaatgcca tcaccatttc cattgagaat ttaaaactca 3180 ccagtgttta atatgcaggc ttccaaaggc ttatgaaaaa aatcaagacc cttaaatcta 3240 gttaatttgc tgctaacatg aaactctttg gttcttttat ttttgccaga taattagaca 3300 cacatctaaa gcttagtctt aaatggctta agtgtagcta ttgattagtg ctgttgctag 3360 ttcagaaaga aatgtttgtg aatggaaaca agaatattca gtccaaactg ttgtaaggac 3420 agtacctgaa aaccaggaaa caggataatg gaaaaagtct tttaaagatg aaatgttgga 3480 gccaactttc ttatagaatt aattgtatgt ggctatagaa agcctaatga ttgttgctta 3540 tttttgagag catattattc ttttatgacc ataatcttgc tgtttttcca tcttccaaaa 3600 gatcttcctt ctaatatgta tatcagaatg tgggtagcca gtcagacaaa ttcatattgg 3660 ttggtagctt taaaaagttt gtaatgtgaa gacaggaaag gacaaaatag tttgctttgg 3720 tggtagtact ctggttgtta agctaggtat tttgagacta cttccccatc acaacaacaa 3780 taaaataatc actcataatc ctatcacctg gagacatagc catcgttaat atgttagtga 3840 ctatacaatc atgttttctt ctgtatatcc atgtatattc tttaaaaatg aaatttatac 3900 tgtacctgat ctcaaagctt tttagcttag tatatctgtc atgaatttgt aggatgttcc 3960 attgcatcag aaaacggaca gtgatttgat tactttctaa tgccacagat gcagattaca 4020 tgtagttatt gagaatcctt tcgaattcag tggcttaatc atgaatgtct aaatattgtt 4080 gacattagga tgatacatgt aaattaaagt tacatttgtt tagcatagac aagcttaaca 4140 ttgtagatgt ttctcttcaa aaatcatctt aaacatttgc atttggaatt gtgttaaata 4200 gaatgtgtga aacactgtat tagtaaactt catcaccttt ctacttcctt atagtttgaa 4260 cttttcagtt tttgtagttc ccaaacagtt gctcaattta gagcaaatta atttaacacc 4320 tgccaaaaaa aggctgctgt tggcttatca gttgtcttta aattcaaatg ctcatgtgac 4380 ttttatcaca tcaaaaaata tttcattaat gattcacctt tagctctgaa aattaccgcg 4440 tttagtaatt atagtgggct tataaaaaca tgcaactctt tttgatagtt atttgagaat 4500 tttggtgaaa aatatttagc tgagggcagt atagaactta taaaccaata tattgatatt 4560 tttaaaacat ttttacatat aagtaaactg ccatctttga gcataactac atttaaaaat 4620 aaagctgcat atttttaaat caagtgttta acaagaattt atatttttta ttttttaaaa 4680 ttaaaaataa tttatatttc ctctgttgca tgaggattct catctgtgct tataatggtt 4740 agagatttta tttgtgtgga atgaagtgag gcttgtagtc atggttctag tgtttcagtt 4800 tgccaagtct gtttactgca gtgaaattca tcaaatgttt cagtgtggtt ttctgtagcc 4860 tatcatttac tggctatttt tttatgtaca cctttaggat tttctgccta ctctatccag 4920 ttgtccaaat gatatcctac attttacaaa tgccctttca gtttctattt tctttttcca 4980 ttaaattgcc ctcatgtcct aatgtgcann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5040 nnnnnnnnnn nattttcaag agtgctagac ttccaatttg agagattaaa taatttaatt 5100 caggcaaaca tttttcattg gaatttcaca gttcattgta atgaaaatgt taatcctgga 5160 tgacctttga catacagtaa tgaatcttgg atattaatga atttgttagt agcatcttga 5220 tgtgtgtttt aatgagttat tttcaaagtt gtgcattaaa ccaaagttgg catactggaa 5280 gtgtttatat caagttccat ttggctactg atggacaaaa aatagaaatg ccttcctatg 5340 gagagtattt ttcctttaaa aaattaaaaa ggttaattat tttgact 5387 <210> 197 <211> 8239 <212> DNA <213> Homo sapiens <400> 197 gtacataagc agcagaagtc actcgcgcag ctgcggcgca ttagttccaa tagtttaacg 60 ggctgctttg tagcacggac aaagccgtgc gagcgcggtg ctttccctcc ttgttcattt 120 gctatgcgag cttgtcagtg atctttggca ggggcttggg agaggagggg tgacgtttaa 180 tacgcttccg cggaggagtg cgctcgcttc ctctgcaccc agccccaggc tctacagaga 240 gactgaggca ggcgactgaa tgcactaaca gcagcaggct cagacctgct tccctggaca 300 tttccgggac cgtgagcgag ggacaccacg ttgccctgga ttcttgccag ctgtacaaag 360 ttgaccagga aaatggctca gcagacaagc ccggacactt taacagtacc tgaagtggat 420 aatccgcatt gtccaaaccc gtggctgaac gaagaccttg tgaaatcctt gcgagaaaac 480 ctgttgcagc atgagaagtc caagacagcg aggaaatcgg tttctcccaa gctctctcca 540 gtgatctctc cgagaaattc cgcccaggct tctgcgcaga atgcttctca gcagcaacat 600 ccccaaacag cggcgtttca cggtggcaca tacatgtttt gatgtggaca atggcacatc 660 tgcgggacgg agtcccttgg atcccatgac cagcccagga tccgggctaa ttctccaagc 720 aaattttgtc cacagtcaac gacgggagtc cttcctgtat cgatccgaca gcgattatga 780 cctctctcca aagtctatgt cccggaactc ctccattgcc agtgatatac acggagatga 840 cttgattgtg actccatttg ctcaggtctt ggccagtctg cgaactgtac gaaacaactt 900 tgctgcatta actaatttgc aagatcgagc acctagcaaa agatcaccca tgtgcaacca 960 accatccatc aacaaagcca ccataacaga ggaggcctac cagaaactgg ccagcgagac 1020 cctggaggag ctggactggt gtctggacca gctagagacc ctacagacca ggcactccgt 1080 cagtgagatg gcctccaaca agtttaaaag gatgcttaat cgggagctca cccatctctc 1140 tgaaatgagt cggtctggaa atcaagtgtc agagtttata tcaaacacat tcttagataa 1200 gcaacatgaa gtggaaattc cttctccaac tcagaaggaa aaggagaaaa agaaaagacc 1260 aatgtctcag atcagtggag tcaagaaatt gatgcacagc tctagtctga ctaattcaag 1320 tatcccaagg tttggagtta aaactgaaca agaagatgtc cttgccaagg aactagaaga 1380 tgtgaacaaa tggggtcttc atgttttcag aatagcagag ttgtctggta accggccctt 1440 gactgttatc atgcacacca tttttcagga acgggattta ttaaaaacat ttaaaattcc 1500 agtagatact ttaattacat atcttatgac tctcgaagac cattaccatg ctgatgtggc 1560 ctatcacaac aatatccatg ctgcagatgt tgtccagtct actcatgtgc tattatctac 1620 acctgctttg gaggctgtgt ttacagattt ggagattctt gcagcaattt ttgccagtgc 1680 aatacatgat gtagatcatc ctggtgtgtc caatcaattt ctgatcaata caaactctga 1740 acttgccttg atgtacaatg attcctcagt cttagagaac catcatttgg ctgtgggctt 1800 taaattgctt caggaagaaa actgtgacat tttccagaat ttgaccaaaa aacaaagaca 1860 atctttaagg aaaatggtca ttgacatcgt acttgcaaca gatatgtcaa aacacatgaa 1920 tctactggct gatttgaaga ctatggttga aactaagaaa gtgacaagct ctggagttct 1980 tcttcttgat aattattccg ataggattca ggttcttcag aatatggtgc actgtgcaga 2040 tctgagcaac ccaacaaagc ctctccagct gtaccgccag tggacggacc ggataatgga 2100 ggagttcttc cgccaaggag accgagagag ggaacgtggc atggagataa gccccatgtg 2160 tgacaagcac aatgcttccg tggaaaaatc acaggtgggc ttcatagact atattgttca 2220 tcccctctgg gagacatggg cagacctcgt ccaccctgac gcccaggata ttttggacac 2280 tttggaggac aatcgtgaat ggtaccagag cacaatccct cagagcccct ctcctgcacc 2340 tgatgaccca gaggagggcc ggcagggtca aactgagaaa ttccagtttg aactaacttt 2400 agaggaagat ggtgagtcag acacggaaaa ggacagtggc agtcaagtgg aagaagacac 2460 tagctgcagt gactccaaga ctctttgtac tcaagactca gagtctactg aaattcccct 2520 tgatgaacag gttgaagagg aggcagtagg ggaagaagag gaaagccagc ctgaagcctg 2580 tgtcatagat gatcgttctc ctgacacgta acagtgcaaa aactttcatg ccnnnnnnnn 2640 nnnnnnnnnn nnnnnttgtt tccaaagtgc atgtcacatg ccacaaccac ggtcacacct 2700 cactgtcatc tgccaggacg tttgttgaac aaaactgacc ttgactactc agtccagcgc 2760 tcaggaatat cgtaaccagt tttttcacct ccatgtcatc cgagcaaggt ggacatcttc 2820 acgaacagcg tttttaacaa gatttcagct tggtagagct gacaaagcag ataaaatcta 2880 ctccaaatta ttttcaagag agtgtgactc atcaggcagc ccaaaagttt attggacttg 2940 gggtttctat tcctttttat ttgtttgcaa tattttcaga agaaaggcat tgcacagagt 3000 gaacttaatg gacgaagcaa caaatatgtc aagaacagga catagcacga atctgttacc 3060 agtaggagga ggatgagcca cagaaattgc ataattttct aatttcaagt cttcctgata 3120 catgactgaa tagtgtggtt cagtgagctg cactgacctc tacattttgt atgatatgta 3180 aaacagattt tttgtagagc ttacttttat tattaaatgt attgaggtat tatatttaaa 3240 aaaaactatg ttcagaactt catctgccac tggttatttt tttctaagga gtaacttgca 3300 agttttcagt acaaatctgt gctacactgg ataaaaatct aatttatgaa ttttacttgc 3360 accttatagt tcatagcaat taactgattt gtagtgattc attgtttgtt ttatatacca 3420 atgacttcca tattttaaaa gagaaaaaca actttatgtt gcaggaaacc ctttttgtaa 3480 gtctttcttt attatttact ttgcattttg tttcactctt tccagataag cagagttgct 3540 cttcaccagt gtttttcttc atgtgcaaag tgactatttg ttctataata cttttatgtg 3600 tgttatatca aatgtgtctt aagcttcatg caaactcagt catcagttcg tgttgtctga 3660 agcaagtggg agatatataa atacccagta gctaaaatgg tcagtctttt ttagatgttt 3720 tcctacttag tatctcctaa taacgttttg ctgtgtcact agatgttcat ttcacaagtg 3780 catgtctttc taataatcca cacatttcat gctctaataa tccacacatt tcatgctcat 3840 ttttattgtt tttacagcca gttatagtaa gaaaaaggtt tttccccttg tgctgcttta 3900 taatttagcg tgtgtctgaa ccttatccat gtttgctaga tgaggtcttg tcaaatatat 3960 cactaccatt gtcaccggtg aaaagaaaca ggtagttaag ttagggttaa cattcatttc 4020 aaccacgagg ttgtatatca tgactagctt ttactcttgg tttacagaga aaagttaaac 4080 agccaactag gcagttttta agaatattaa caatatatta acaaacacca atacaactaa 4140 tcctatttgg ttttaatgat ttcaccatgg gattaagaac tatatcagga acatccctga 4200 gaaacggttt taagtgtagc aactactctt ccttaatgga cagccacata acatgtagga 4260 agtcctttat cacttatcct cgatccataa gcatatcttg cagaggggaa ctacttcttt 4320 aaacacatgg agggaaagaa gatgatgcca ctggcaccag agggttagta ctgtgatgca 4380 tcctaaaata tttattatat tggtaaaaat tctggttaaa taaaaaatta gagatcactc 4440 ttggctgatt tcagcaccag gaactgtatt acagttttag agattaattc ctagtgttta 4500 cctgattata gcagttggca tcatggggca tttaattctg actttatccc cacgtcagcc 4560 ttaataaagt cttctttacc ttctctatga agactttaaa gcccaaataa tcatttttca 4620 cattgatatt caagaattga gatagataga agccaaagtg ggtatctgac aagtggaaaa 4680 tcaaacgttt aagaagaatt acaactctga aaagcattta tatgtggaac ttctcaagga 4740 gcctcctggg gactggaaag taagtcatca gccaggcaaa tgactcatgc tgaagagagt 4800 ccccatttca gtcccctgag atctagctga tgcttagatc ctttgaaata aaaattatgt 4860 ctttataact ctgatctttt acataaagca gaagaggaat caactagtta attgcaaggt 4920 ttctactctg tttcctctgt aaagatcaga tggtaatctt tcaaataaga aaaaaataaa 4980 gacgtatgtt tgaccaagta gtttcacaag aatatttggg aacttgtttc ttttaatttt 5040 atttgtccct gagtgaagtc tagaaagaaa ggtaaagagt ctagagttta ttcctctttc 5100 caaaacattc tcattcctct cctccctact cttagtattt cccccacaga gtgcctagaa 5160 tcttaataat gaataaaata aaaagcagca atatgtcatt aacaaatcca gacctgaaag 5220 ggtaaagggt ttataactgc actaataaag agaggctctt tttttttctt ccagtttgtt 5280 ggtttttaat ggtaccgtgt tgtaaagata cccactaatg gacaatcaaa ttgcagaaaa 5340 ggctcaatat ccaagagaca gggactaatg cactgtacaa tcggcttatc cttgcccttc 5400 tctcttgcca aagtgtgctt cagaaatata tactgcttta aaaaagaata aaagaatatc 5460 cttttacaag tggctttaca tttcctaaaa tgccataaga aaatgcaata tctgggtact 5520 gtatggggaa aaaaatgtcc aagtttgtat aaaaccagtg catttcagct tgcaagttac 5580 tgaacacaat aatgctgttt taattttgtt ttatatcagt taaaattcac aataatgtag 5640 atagaacaaa ttacagacaa ggaaagaaaa aacttgaatg aaatggattt tacagaaagc 5700 tttatgataa tttttgaatg cattatttat tttttgtgcc atgcattttt tttctcacca 5760 aatgacctta cctgtaatac agtcttgttt gtctgtttac aaccatgtat ttattgcaat 5820 gtacatactg taatgttaat tgtaaattat ctgttcttat taaaacatca tcccatgatg 5880 ggatggtgtt gatatatttg gaaactcttg gtgagagaat gaatggtgtg tatacatact 5940 ctgtacattt ttcttttctc ctgtaatata gtcttgtcac cttagagctt gtttatggaa 6000 gattcaagaa aactataaaa tacttaaaga tatataaatt taaaaaaaca tagctgcagg 6060 tctttggtcc cagggctgtg ccttaacttt aaccaatatt ttcttctgtt ttgctgcatt 6120 tgaaaggtaa cagtggagct agggctgggc attttacatc caggctttta attgattaga 6180 attctgccaa taggtggatt ttacaaaacc acagacaacc tctgaaagat tctgagaccc 6240 ttttgagaca gaagctctta agtacttctt gccagggagc agcactgcat gtgtgatggt 6300 tgtttgccat ctgttgatca ggaactactt cagctacttg catttgatta tttccttttt 6360 ttcttttttt ataactcgga aacacaactg gggaaatata ttctttccca gtgattataa 6420 acaatctttt tctttttttt aagtcctttt ggcttctaga gctcatagga aaatggactt 6480 gatttgaaat tggagccaga gtttactcgt gttggttatc tattcatcag cttcctgaca 6540 tgttaagaga atacattaaa gagaaaatac tgttttttaa tcctaaaatt tttcttccac 6600 taagataaac caaatgtgct tacatatatg taaacccatc tatttaaacg caaaggtggg 6660 ttgatgtcag tttacatagc agaaagcatt cactatcctc taagatttgt ttctgcaaaa 6720 ctttcattgc tttagaattt taaaatttca ccttgtacaa tggccagccc ctaaagcagg 6780 aaacatttat aatggattat atggaaacat cctcccagta cttgcccagc ccttgaatca 6840 tgtggctttt cagtgaaagg aaagattctt tttctaggaa aaatgagcct attttatttt 6900 attttatttt attttttgac acaaactgta gattttagca gccctggccc aaaggaattt 6960 gattactttt gttttaaaca gtacaaaggg gacactataa ttacaaaaac atccttaact 7020 gatttgagtt gtttttattt ctttggatat attttcagag tggtaaattg tgtgtgagaa 7080 ttacaaatga ttattctttt agtggtttct tagcctctct tacagcccac ggggatagta 7140 ctgtacatca ataccttcat atgaaatttt tatatgcaat gaaaataaaa gcatgggttg 7200 attctgccta tttatgactc aatcttttac aaataaaaga ttattcattt taaattatag 7260 ttcaatcagc atgtctctta ggatactgaa cgtggttgaa atgaaaggat agtgacatca 7320 taagttagta ctgatattca taaccaaata aagccaactt gagtaatttt gctacattaa 7380 aaattaccaa aattacttag atggcctata agattaacgc atggtgtttt ctaagcaagc 7440 tttgaaaggg gccttccata cttacttaat tgaatattct gggatattga aaattattca 7500 gatacttgac aattattttt ggttacctac tccgcaaact acaaagtttt aaggactcaa 7560 caataagtta atgagacaca gtgtttgctt tcatggagct tacagtctgg aggggacaaa 7620 ggcttaaaca atactcatat aattatatat gtgatcagta caatgaagga gctcagtggg 7680 gtaaataagc aggaacctga acttgatctg ttccggaggg ccacagaagg cttccttgag 7740 gccttgagaa agtgatttgc atctgagttc tgaaggattg taagaggtaa ctagggaaaa 7800 agttgacagg aagaggaagg ggatccagac aagaaacatt tgcaaagatc ttgaggcata 7860 aatgagcttg agacatctgg agaaactgag gaaaagtgag agagtaggca gggcctggag 7920 ccgcagagcc attgctaacc atcctgtgtg agatatcccc cattctgtag ctttattctc 7980 ataaccctgc tcaattttct ttataacact tctcacagat ttatatacgt gtttgttttt 8040 gttatctgtc tctcccacca gaccacagct ccatgagagc aaggtctttg cttaccaata 8100 tatcactagc acttaaaact atgcctggta cacagtaggt tcttaatatg tgttgaatat 8160 agccatcaaa ttgatattgg atataattca atctgataag atattttgag atattaaaga 8220 gtttttaact tgatcccat 8239 <210> 198 <211> 2346 <212> DNA <213> Homo sapiens <400> 198 atttataaat aaaatctatg ccatccagga ggtatgtgtc agtgtccaga acatcctaga 60 tgaagtggct tcctttggcg aaaggataaa gaatactttc aactggactg tcccattctt 120 aagctggctg gccattgtag ccctctgtgt gttcacagcc atcctgtact gcattccgct 180 gagatacatt gtccttgtct ggggcatcaa taaatttaca aaaaagcttc ggagtccata 240 tgcaattgat aacaatgaac tacttgactt cctttccaga gtcccttcag atgtacaagt 300 ggtgcaatac caagaactga aaccagatcc ttctcatagc ccatataaaa gaaagaaaaa 360 caatcttggc tagccagctc ccagcactga ggagaccagc atctgtttgg gaagataaaa 420 gaaaaagccc tcagcctcag cagcatttcc tttctttctg ctttttattt attttgcctt 480 tttatcatga tcgagagaat ctgtaaatag tgtacaaagg catatgtctt tgaatatata 540 cttctattgt acagactcaa cttgataaag gttttgctac tgctgtgtca aaaccttgtt 600 agctgtggat aataatataa cacactgaaa gaacaaatat aagaatgata acactggaag 660 atatattctt atctaattac tagtggatta aatactcacc tgtgctctga ttaaatctac 720 atcaattgta aatgtcgatt tgattttaaa gttttttttt taatgcgact attttttatc 780 tgaaaagtaa tccattacac ttttctatgt tttatacatt tcaaaaggga gggaaattcc 840 aaagcctgaa taatggaatg gatacatttc aatttaacat atattctggc tttagatccc 900 gacattcact cctgtgcaaa ttacttaggt atgacttagg ctaattttaa gctaataagt 960 gaaggtacat tcactccctc aagagaatca atactcagaa ggttacaaag ttttctttat 1020 agaatttcaa tcaatcattc catctaaaac cttaaaatct ctacaggact acataacata 1080 aatactgcca gtttataaac gattgcctat ctgaattttt atacctacca ctactttaat 1140 ttatacagtt agttagcaaa ttagcaaccc agtaagtaca gttatcaaaa atactaggaa 1200 actatatcca tatcgctttt ggtgtcagat tgtatctgtg catctaaaaa tattttaata 1260 aatactcaag tgctctcaga gaaaaaaaaa acctgctttc tcattagatt actgaaatgc 1320 tttaattcat actatgattt tgttattagt gtgaatttta atgtagagaa ttcagtgtgc 1380 taagtgatat gccagtgttt cactacattc atttattaaa aaaaatcatt cttgattatg 1440 catgaaaacc tgttttgtaa aataaaataa actgcttggg ggtggtggtt gcctttatca 1500 atgtttcact attatcatag aatctatact taaaaattgc attcccaaga ctcttaaagt 1560 agtttttata tctcactccc tggtatacta agggagcata actctggaga aaaaataatt 1620 tggttggttg agaatgtctt acttccctga cttggtaggg gactacactc agttgaaatt 1680 gcagcagaca atgctttgca ctactttatt aataataaac ttggatgggg taaaagtggg 1740 ggttatactg gaaaaactat agaaaagcta aaagaaatgt atatttcact ctaaaggaag 1800 attctttaac aataaatgta atctcattga agctgatttt taaagtattt ttattttaga 1860 gataagttgt taaatactat ttcttataat agaactattt tgatctgttt atatactatg 1920 cttgaatgtc aattaaattc cctttctaca gaaaggcttt gacctcaaca tgctttattt 1980 aatgtatcat gtttaaaatg acatgcttct gtctgcatac catcactgtt tgttgctaaa 2040 aacataatgt tccatgaaca tgatgttact acagaaagtt tattgatgag ataactgttt 2100 gaaataactt tcaattatac cttatgtgag acttttatgt tctgtgctga caatgtgtac 2160 tcaaatgtct ataagcctga tattctacaa cctcagatgt atctagtgga tagtaaccat 2220 taacagatga ctaatttgtt tcactgtatc aaatttcaga tgtttagttc aatggtaatg 2280 ctgactacac attcactgta ttaaatacaa aagaaaataa tctttcccac gtataatcag 2340 cactcc 2346 <210> 199 <211> 1453 <212> DNA <213> Homo sapiens <400> 199 tccaggtact ggaaaatctg aggctactag agactggagc gggccctggg catactgcag 60 cagccctatg gaaaagtggc cagactgtta cctgggttcc cattcctata tcttctcact 120 aggcaagtct tgcaggcctg gacctctacc taaccccccc taccagaact gttgagccag 180 tagcaactca gccactccct ggagagagcc tccaggggca actgaaagcc tctctgccac 240 tgcttctgca gtggaactgt ccttgctacc ctcagactga tgaaggagct aacaccctta 300 tctacacctt caacaagctt taattgacca aagcccatct ctcatgggtt ctacacactc 360 cccactgctc atgacaggga acccctggat tggcccccac agcacgaatt ctccatcctg 420 attgctgatt gcagtaaaca gttgctgtat tctccagggg tggtggaact ctgaggagac 480 aaacaaaaga cccttggcta caaccactac taatgtccct tcctcttctg cctcaaagtt 540 aggaaagaaa tataaacact gagattgccc cagagctgca gtgggcagcc taggagtgcc 600 aagccatgac ctacagccag cactcaaggg ggagagaagc acattttcag atcattgaga 660 gggaacatgg ctgcaactgt aaggaaacat aggggagcca catgaccaag caagagtcta 720 ccaactgacc agtaagccca agtgccacct actggatcac atcccaaagc ttcagcatca 780 aaaatacctt actaatatac tcccctctga aaccagaaat gagaagtcag cttcaaataa 840 agaccctgca caaagcctca gcctggtgaa aacatccgaa aataagtcta cggactgtac 900 tcaatctaca ctgcaattaa aggaaaaccc ataggtggaa atgagaagaa accaatgcaa 960 gaactccagt aactcaaatg gcctctgtgt catatgtcct tctaacaacc acaccagttc 1020 tccaacaaga gttcttaacc tggatgaact gtctggaatt acataaatat aattcagaat 1080 atggatagga aaaaaaatca tcaagactca ggagaatggc aaaacccaat ccgaggaaaa 1140 taagaataac agtaaagtgt tacaggagct gaaggataaa gtagctggta taataaaaaa 1200 gaacctaacc gatctgaaag cgccgaagaa cacaatacaa gaattccaca atgcaatcac 1260 aagtattaac agcagaaaaa aaaatctgag gaacgaatct cagaacttga agattggttc 1320 tctnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt 1380 tatataaaga ggccaattct acaaatcact ggcatctctg aaagggaggt ggagaaatca 1440 aacaacttgg aaa 1453 <210> 200 <211> 5142 <212> DNA <213> Homo sapiens <400> 200 gtgctgccgt gacactcggc cctccagtgt tgcggagagg caagagcagc gaccgcggca 60 cctgtccgcc cggagctggg acgcgggcgc ccgggcggcc ggacgaagcg aggagggacc 120 gccgaggtgc gcgtctgtgc ggctcagcct ggcgggggac gcggggagaa tgtggactgg 180 gtagagatga acgagacttt tctcagatgt tggatatttg cttggaaaaa cgtgtgggta 240 cgaccttggc tgcccccaag tgtaactcca gcactgtgag gtttcaggga ttggcagagg 300 ggaccaaggg gaccatgaaa atggacatgg aggatgcgga tatgactctg tggacagagg 360 ctgagtttga agagaagtgt acatacattg tgaacgacca cccctgggat tctggtgctg 420 atggcggtac ttcggttcag gcggaggcat ccttaccaag gaatctgctt ttcaagtatg 480 ccaccaacag tgaagaggtt attggagtga tgagtaaaga atacatacca aagggcacac 540 gttttggacc cctaataggt gaaatctaca ccaatgacac agttcctaag aacgccaaca 600 ggaaatattt ttggaggatc tattccagag gggagcttca ccacttcatt gacggcttta 660 atgaagagaa aagcaactgg atgcgctatg tgaatccagc acactctccc cgggagcaaa 720 acctggctgc gtgtcagaac gggatgaaca tctacttcta caccattaag cccatccctg 780 ccaaccagga acttcttgtg tggtattgtc gggactttgc agaaaggctt cactaccctt 840 atcccggaga gctgacaatg atgaatctca cacaaacaca gagcagtcta aagcaaccga 900 gcactgagaa aaatgaactc tgcccaaaga atgtcccaaa gagagagtac agcgtgaaag 960 aaatcctaaa attggactcc acccctccaa ggaaaggacc tctaccgttc taacatttca 1020 cccctcacat cagaaaagga cctcgatgac tttagaagac gtgggagccc cgaaatgccc 1080 ttctaccctc gggtcgttta ccccatccgg gcccctctgc cagaagactt tttgaaagct 1140 tccctggcct acgggatcga gagacccacg tacatcactc gctcccccat tccatcctcc 1200 accactccaa gcccctctgc aagaagcagc cccgaccaaa gcctcaagag ctccagccct 1260 cacagcagcc ctgggaatac ggtgtcccct gtgggccccg gctctcaaga gcaccgggac 1320 tcctacgctt acttgaacgc gtcctacggc acggaaggtt tgggctccta ccctggctac 1380 gcacccctgc cccacctccc gccagctttc atcccctcgt acaacgctca ctaccccaag 1440 ttcctcttgc ccccctacgg catgaattgt aatggcctga gcgctgtgag cagcatgaat 1500 ggcatcaaca actttggcct cttcccgagg ctgtgccctg tctacagcaa tctcctcggt 1560 gggggcagcc tgccccaccc catgctcaac cccacttctc tcccgagctc gctgccctca 1620 gatggagccc ggaggttgct ccagccggag catcccaggg aggtgcttgt cccggcgccc 1680 cacagtgcct tctcctttac cggggccgcc gccagcatga aggacaaggc ctgtagcccc 1740 acaagcgggt ctcccacggc gggaacagcc gccacggcag aacatgtggt gcagcccaaa 1800 gctacctcag cagcgatggc agcccccagc agcgacgaag ccatgaatct cattaaaaac 1860 aaaagaaaca tgaccggcta caagaccctt ccctacccgc tgaagaagca gaacggcaag 1920 atcaagtacg aatgcaacgt ttgcgccaag actttcggcc agctctccaa tctgaaggtc 1980 cacctgagag tgcacagtgg agaacggcct ttcaaatgtc agacttgcaa caagggcttt 2040 actcagctcg cccacctgca gaaacactac ctggtacaca cgggagaaaa gccacatgaa 2100 tgccaggtct gccacaagag atttagcagc accagcaatc tcaagaccca cctgcgactc 2160 cattctggag agaaaccata ccaatgcaag gtgtgccctg ccaagttcac ccagtttgtg 2220 cacctgaaac tgcacaagcg tctgcacacc cgggagcggc cccacaagtg ctcccagtgc 2280 cacaagaact acatccatct ctgtagcctc aaggttcacc tgaaagggaa ctgcgctgcg 2340 gccccggcgc ctgggctgcc cttggaagat ctgacccgaa tcaatgaaga aatcgagaag 2400 tttgacatca gtgacaatgc tgaccggctc gaggacgtgg aggatgacat cagtgtgatc 2460 tctgtagtgg agaaggaaat tctggccgtg gtcagaaaag agaaagaaga aactggcctg 2520 aaagtgtctt tgcaaagaaa catggggaat ggactcctct cctcagggtg cagcctttat 2580 gagtcatcag atctacccct catgaagttg cctcccagca acccactacc tctggtacct 2640 gtaaaggtca aacaagaaac agttgaacca atggatcctt aagattttca gaaaacactt 2700 attttgtttc ttaagttatg acttggtgag tcagggtgcc tgtaggaagt ggcttgtaca 2760 taatcccagc tctgcaaagc tctctcgaca gcaaatggtt tcccctcacc tctggaatta 2820 aagaaggaac tccaaagtta ctgaaatctc agggcatgaa caaggcaaag gccatatata 2880 tatatatata tatatatata tatctgtata catattatat atacttattt acacctgtgt 2940 ctatatattt gcccctgtgt attttgaata tttgtgtgga catgtttgca tagccttccc 3000 attactaaga ctattaccta gtcataatta ttttttcaat gataatcctt cataatttat 3060 tatacaattt atcattcaga aagcaataat taaaaaagtt tacaatgact ggaaagattc 3120 cttgtaattt gagtataaat gtatttttgt cttgtggcca ttctttgtag ataatttctg 3180 cacatctgta taagtaccta agatttagtt aaacaaatat atgacttcag tcaacctctc 3240 tctctaataa tggtttgaaa atgaggtttg ggtaattgcc aatgttggac agttgatgtg 3300 ttcattcctg ggatcctatc atttgaacag cattgtacat aacttggggg tatgtgtgca 3360 ggattaccca agaataactt aagtagaaga aacaagaaag ggaatcttgt atatttttgt 3420 tgatagttca tgtttttccc ccagccacaa ttttaccgga agggtgacag gaaggcttta 3480 ccaacctgtc tctccctcca aaagagcaga atcctcccac cgccctgccc tccccaccga 3540 gtcctgtggc cattcagagc ggccacatga cttttgcatc cattgtatta tcagaaaatg 3600 tgaagaagaa aaaaatgcca tgttttaaaa ccactgcgaa aatttcccca aagcataggt 3660 ggctttgtgt gtgtgcgatt tgggggcttg agtctgggtg gtgttttgtt gnnnnnnnnn 3720 nnnnnnnnnn nnnnnnnnnn nnnnnnnaat gtcaaaattg cacaaacatg gtgctctacc 3780 aggaaggatt cgaggtagat aggctcaggc cacactttaa aaacaaacac acaaacaaca 3840 aaaaacgggt attctagtca tcttggggta aaagcgggta atgaacattc ctatccccaa 3900 cacatcaatt gtattttttc tgtaaaactc agattttcct cagtatttgt gtttttacat 3960 tttatggtta atttaatgga agatgaaagg gcattgcaaa gttgttcaac aacagttacc 4020 tcattgagtg tgtccagtag tgcaggaaat gatgtcttat ctaatgattt gcttctctag 4080 aggagaaacc gagtaaatgt gctccagcaa gatagacttt gtgttattct atcttttatt 4140 ctgctaagcc caaagattac atgttggtgt tcaaagtgta gcaaaaaatg atgtatattt 4200 ataaatctat ttataccact atatcatatg tatatatatt tataaccact taaattgtga 4260 gccaagccat gtaaaagatc tactttttct aagggcnnnn nnnnnnnnnn nnnnnnnnnn 4320 nnnnnnctcc tttctgagac tttgcttaat acttggtgac ctcacaatca cgtcggtatg 4380 attgggcacc cttgcctact gtaagagacc ctaaaacctt ggtgcagtgg tggggaccac 4440 aaaacaacca gggaggaaga gatacatcat tttttagtat taaggaccat ctaagacagc 4500 tctatttttt ttttgccact ttatgattat gtggtcacac ccaagtcaca gaaataaaaa 4560 actgacttta ccgctgcaat ttttctgttt tcctccttac taaatactga tacattactc 4620 caatctattt tataattata tttgacattt tgttcacatc aactaatgtt cacctgtaga 4680 agagaacaaa tttcgaataa tccagggaaa cccaagagcc ttactggtct tctgtaactt 4740 ccaagactga cagcttttta tgtatcagtg tttgataaac acagtcctta actgaaggta 4800 aaccaaagca tcacgttgac attagaccaa atacttttga ttcccaacta ctcgtttgtt 4860 ctttttctcc ttttgtgctt tcccatagtg agaattttta taaagacttc ttgcttctct 4920 caccatccat ccttctcttt tctgcctctt acatgtgaat gttgagccca caatcaacag 4980 tggttttatt ttttcctcta ctcaaagtta aaactgacca aagttactgg ctttttactt 5040 tgctagaaca acaaactatc ttatgtttac atactggttt acaatgttat ttatgtgcaa 5100 attgtcaaaa tgtaaattaa atataaatgt tcatgcttta cc 5142 <210> 201 <211> 2781 <212> DNA <213> Homo sapiens <400> 201 cttttaaagc gtggcgcgcc agggnccggg catgccgagc cccgtggcgg agacagcggt 60 gcgctcagct cccgggagcg gcccgagcag ccgagcgccc agggctgccc ttcccgggcc 120 ggcgggctcc ccgggctccc cgccgccgcc ccgtgcgccc cgggagggcc cggcatgctg 180 cgccagctgc tgctcgccgc gctctgcctg gcgggtcccc cagcgcccgc gcgcgcctgc 240 cagctgccct ccgagtggag gcccctgagc gagggctgcc gcgccgagct ggccgagacc 300 atcgtgtacg ccagggtgct ggcgctgcac cccgaggcgc ccggcctcta caaccacctg 360 ccctggcagt accacgccgg ccaggggggc ctcttctact cggccgaggt cgagatgctg 420 tgcgaccagg cgtggggcag catgctggag gtgcccgccg gctccaggct caacctcacc 480 ggcctgggct acttctcgtg ccactcccac accgtggtcc aggactactc ctatttcttc 540 ttcctcagga tggatgaaaa ttataacctc ttgcctcacg gagtcaattt ccaagatgcc 600 atcttcccag acactcaaga gaacagaagg atgttttcta gccttttcca gttttcaaac 660 tgttcgcaag ggcagcagct ggcgactttc tccagtgact gggaaatcca ggaagacagt 720 aggctcatgt gctcctcggt gcagaaggcc ttgtttgagg aggaggacca cgtcaagaaa 780 ctgcagcaga aagtggccac cctggagaag cgcaaccggc agctccggga gcgagtgaag 840 aaggtcaaga ggtccttgcg gcaggcgcgt aagaagggcc gccacctgga gctggcgaac 900 cagaaactca gtgagaagct ggcggcgggc gcgctgccgc acatcaacgc ccgggggccc 960 gtgcgccccc cctacctgcg ggggtaacgg gcctgggggc tgccaggtgt gcagggccaa 1020 tcctggcggt aattgagaat gagtgaggtt tcgtacatgc agctatttca agggttgtaa 1080 gagtttttgt ttttaatcac gcatttggta gagtctaaat ggataaaatg caaggcttgc 1140 tttccccttg ggtgctggcc tcaatgtcag accccacgcg ctgccccttc ctggcctgac 1200 cccagacgca gtgcctggca gtccagaggc agtgggatcc ctgagtgctg aatgctcgcc 1260 tgcagagcag cccagaaaga gccctgactg gggagagaac attttagaat ctctagtgta 1320 aaagacatca acgtgcttag cctttatttc agaaaaaaat cagggtggtt cccagctccc 1380 cagtccagga caaccattag tcctgatgag tgagctgacg ctggtgctgg aacctgctgg 1440 cacctcactg gccacatctt tggaagggga tggtggcctt gcatccaaga tgcctgaaaa 1500 tcagcacgtg cagggcctcc ctatccagcc agcattttcc ttccagctga ggcaggtgaa 1560 gacttcataa gctcatcaca ggggagggaa ttaggagcag ggcagcaggt aattaaacaa 1620 gataaattat acctgatttc caacaccagc tacaaagagt tgaagatgat acctatgggt 1680 cgcgttaaca cagggggcaa ctgccttgat cggcctgcca tgggtcatca gactgcttcc 1740 taaattgaga gaaactgagc aatctctcag ccactgctat agtctaactt cttgtttgct 1800 gagtaattgt ttctaatgtc tctgaactca aagtgaggtg ctccaagacg ctgtgaactt 1860 ctgcaaagac acctccttac ctactgggat cacgtgacct gacctcactc ccagccaggc 1920 tcccaaaggg ctcattccag ccattccaat ctcttcttct ttatgcaaac acttttcccc 1980 cacaacaagc cttgtttgtt ccgataggaa tacgtgtacg tcagtgcact tgtccttacg 2040 tcagttcctt acaccaccaa agcacttcac ctttctggaa ataaaacttt taagacacta 2100 ctataagtaa aaatgagagt attcactaga cttattgctc aggcacattt gagtgggtcc 2160 cagctgtgtg attaagaagt caactgggtg gccttttctg ggttatcttc tgatcatggc 2220 ctttcaaccc aacaagggcc cttccctgct cttccaccag taaaggctcc tggcctctca 2280 tcaggatctg ccccccagag acccccccag acactgcagg gcctggtgat gctgtcctct 2340 gtaccggaaa tggcaggcac tgtcagattt ccactcttct gcctttagga aggctgggtg 2400 cttcttgctc tgacagccag tctggggaga tgactcttac gttgcttgag tcttggtggc 2460 aggctgctgt ccacggggga gaagtctctg ctctggactg gacagaagag agacttttac 2520 cctggggcac tcacacggcc aagcttctgc caccacttca ttagctgtat tctccatagt 2580 atggtgaaat agcaggtgcg tcttctagtt tattcctcct ggggacattt cctcaaagca 2640 gttttgcgcc cccgcaaggg aatggtcagc ctaagggtaa tgtacagccc gtgcttggag 2700 aaccatggaa gctacacccc tacaggtgca tactgttctg cttttccaat aaatacgagc 2760 ggcgatttca accacaaaaa a 2781 <210> 202 <211> 3646 <212> DNA <213> Homo sapiens <400> 202 ccttcgcggc gcctgctctg tagagccggc ggaaccgggt agcttggcca ggttgtgagg 60 aaccgcagcg cgccgcagga ccgggccgct gagcctgcag ccgccccgcg ccgtgacctg 120 cgaccctaga ccccgactcc ctttggctca gcccgcgcgc cccaggcccg gcccgggcgg 180 cgcgacggga ggatgagcgg cgggcggcgg aaggaggagc cgcctcagcc gcagctggcc 240 aacggggccc tcaaagtctc cgtctggagt aaggtgctgc ggagcgacgc ggcctgggag 300 gataaggatg aatttttaga tgtgatctac tggttccgac agatcattgc tgtggtcctg 360 ggtgtcattt ggggagtttt gccattacga gggttcttgg gaatagcagg attctgcctg 420 atcaatgcag gagtcctgta cctctacttc agcaattacc tacagattga tgaggaagaa 480 tatggtggca cgtgggagct cacgaaggaa gggtttatga cctcttttgc cttgttcatg 540 tgcttgtctc ctcactaggt catttggatc atcttttaca ctgccatcca ttatgactga 600 tggtgtacag ctcccaagtg ctccctatcc agtccaaagg accctcttga ttacagcaca 660 ggaacttgat cgttggggaa ccccagcccc ttggaacttg gaagacccgt gtttcctgga 720 ccgcgaatca gtgtgttggg catcagtgtt ttctgcaagg gttgtgacct gaaacttttt 780 aaaaaccacc cacctttggg gaagcatttc tgaatttatc catcaccaac catttcttct 840 tggataccat caagtaacag ctattatttg ccaagtggag ctgtcattta atttgatgca 900 cctctggatt cagatgaaac attaaattgt cttcctcgat tctccatcgg gtgtagagtt 960 tttaaactat caatggcatt tcaagtcttc tgaaacagca tggctgtatg tgcgtggtcc 1020 atagcacagt acatgcagca tctaataaga gtttccattg tagaatgttt tcacatactt 1080 gaataaatca aatctttaat tgagaacctg ttgatgatac ctgataaagc ctttcccacc 1140 ccacctgtag cttgggaacc agtaggagca ctggaggggg tgcctcccac cccatccctc 1200 tttcttcctc tccctgatcc cttagcggat ccagcagacc tctttctgtt tatggaggca 1260 gcagggaaat caagggctgg atttggtgta ggctgtggtc tccgtcttgg cattgtggag 1320 agagggctta gcaccttctg atgcccctgc ccagcactga ggtgcctggc ctcactgcag 1380 tgtgctagac ttaagaggtg ttatttttta ttcggccaca agatggcaag gccagtgtgc 1440 tagggaatgg taagccacaa aatgaaatag agatctgaga gctaggctgg gtgccgtggc 1500 tcacacctgt aatcccagca ctttgggagg ccaaggtggg tggatcacct gaggtcagga 1560 gttcgacacc agcctggcca atgtggtgaa accccatgtc tactaaaaat acaaaaaaat 1620 tagccaggca tggtggtgta cgcctgtaat cccagctatt ctggaggctg aggcaggaga 1680 attgtttgaa tccaggagat ggaggttgca gtgagctgag atcgtgccat tgcactccag 1740 tcatgggcaa cagggcaaga ntccgtcnca aaaaaaagta aaaagagctg gggctgttgt 1800 cctcaatggg ggacatttga ggacctagac tgtccgaagt ctttctcttt gctctggagg 1860 tcacatagag cctggaccat ccaagatctg ctgctacggt aagacatcat ctcagctttc 1920 ctttcccttc taggccacag tcctaccttc tgaggtatgg tggtggtctc aacgagactt 1980 gtagattttc tgaaaatgac tttctcgttg actctagggg ttgtttctac cttgtgggtg 2040 gggcctggtt aatggtgggg atgtagaatg gggctcaaca ggcagggcat ccagatggta 2100 ctggaaaccc caaactcaag aactaactag gtcagacccc ccaggaggct tattctcttt 2160 ttggaaccct ggccctggtc ccaccttctc tgcactcgca ctagaggtcg caggtgggat 2220 catggcactg gaaggaagta ggtgacttct aagggctaag agaggaaaga gcaagggtac 2280 aggtgggacc ctagatgcac ctctgtgtcc caccctccct ccctgagtgc acagccttgc 2340 ctctggggtg cccaggaggc tgaattgggg ttctaggtgt gcagccttgg tttccctttt 2400 ggcctctcct ttgggcctag gcatcatcca aagagacagc ctcgtcattc aggctgatgt 2460 agaagctgag ggactcccgg agaccctcac tgagaagaga ctcctcccct gtggcagctt 2520 cagaaaacag gagggagctg tccagctctt tccagttgag tggtgtcctc tgcacagtca 2580 caggtagggg tatatccttg ccagggagcg ggccagccct ctgcaggaca cagggctcct 2640 tgagtaggca gcagatgtca tccgccagct cagagtaatg gtccaccagg gcctggagtg 2700 aggggaaggt gaggcgcggt gagatgtaca gccagccatt gtcaaggcag tggatcctgt 2760 agtgtctgat ccggtcccag gatgcagggc ggctgaggcg gactgacaga gagtaagagc 2820 ctctcctggt ctggctctcc cggatgagga aggcccctcc agggttccca ggtaacaaca 2880 gcagttcctc tgctttctcc ctgctcaggc cctcatacag ccacccatgg gagactttgg 2940 ccacgtggac gctggggatg ttatactctc tgcctgagac ttcagacagc accgtccacc 3000 agtctccatc ctcagagacg atggtcaatg gctccccgag tctcagcgac agctcggccg 3060 ggccacctgc cgggaaactg cccagggcca cggctgtggc cttgcttctc tctgcttcca 3120 tggtcacagg tccctggcct tggacagagg aactcaagct tgggcttggc agagattttc 3180 ttctgctggg cagacttccc attgttcctc agcagagcac tcagaagcac atcatcgagg 3240 gaaattggtt tgtcatcaaa ggcttgggaa gacagctctg ctgagacgca tgctctggct 3300 ggacaggtta gggctttggg ggcccttctg gaagtctgcc agtgtccttg gtcctaggac 3360 acccagaact ctctcagcct gggaggatct tcagggagag gctaggtgtt ggtttgggta 3420 gctcagcatc tgtctgcagt cagcagtttg tacaccaggg atggatcagc tgccccatgc 3480 tccttaggga ttctggactg gggaaccctc ccaagcacag ccgagccagg gagggaaggc 3540 ccagggccct ttgagctctg tcacagagac acaggcgtgg ggtccttgga gctctagctc 3600 cgactgcaga ctctgtggtt ctcacaacca cccgtttcct ctcccc 3646 <210> 203 <211> 1950 <212> DNA <213> Homo sapiens <400> 203 atcaatgccc gctgcggcct gcccctttct ccgccgtccc ctttcacctg ctgggaaatc 60 acagccctaa tgcttggaga atccaagcag tttccctcta aaaccccagg gttgcgaaac 120 cgcaggggaa acgccaagtc cctgagctgg gctagggacg cggtacgagg tagcacgggc 180 gggccgcgat tcctcgggga ggcgtcccca ttgtcccccc aaccccgacc ctctcccgcc 240 gcggcctggg ccagaagcac ccggccctgc gctgcggagg cgatgccgca tcctggcact 300 aagcccgggc agcggggagg ggcagagaga acccaggggc tgcgggaaac gtggaaaagg 360 agtggcccca tggggacccg ggctcgctac agaccttcgc cctgggggcg gaggggaggg 420 gcccaccacg gccttatttc cgcgagcgcc ggcactgccc gctccgagcc cgtgtctgtc 480 gggtgccgag ccaactttcc tgcgtccatg cagccccgcc ggcaacggct gcccgctccc 540 tgctccgggc ccaggggccc acgccccacc gccccgctgc tcgcgctgct gctgttgctc 600 gccccggtgg cggcgcccgc ggggtccggg ggccccgacg accctgggca gcctcaggat 660 gctggggtcc cgcgcaggct cctgcagcag gcggcgcgcg cggcgcttca cttcttcaac 720 ttccggtccg gctcgcccag cgcgctacga gtgctggccg aggtgcagga gggccgcgcg 780 tggattaatc caaaagaggg atgtaaagtt cacgtggtct tcagcacaga gcgctacaac 840 ccagaggaag gtgagggacg tttggggaaa tgttctgctg cgagtgtttt tcaagaatca 900 gaaacccaga ccaaccatca atgtaacttg tacacggctc atcgagaaaa agaaaagaca 960 acaagaggat tacctgcttt acaagcaaat gaagcaactg aaaaacccct tggaaatagt 1020 cagcatacct gataatcatg gacatattga tccctctctg agactcatct gggatttggc 1080 tttccttgga agctcttacg tgatgtggga aatgacaaca caggtgtcac actactactt 1140 ggcacagctc actagtgtga ggcagtggaa aactaatgat gatacaattg attttgatta 1200 tactgttcta cttcatgaat tatcaacaca ggaaataatt ccctgtcgca ttcacttggt 1260 ctggtaccct ggcaaacctc ttaaagtgaa gtaccactgt caagagctac agacaccaga 1320 agaagcctcc ggaactgaag aaggatcagc tgtagtacca acagagctta gtaatttcta 1380 aaaagaaaaa atgatctttt tccgacttct aaacaagtga ctatactagc ataaatcatt 1440 ctagtaaaac agctaaggta tagacattct aataatttgg gaaaacctat gattacaagt 1500 gaaaactcag aaatgcaaag atgttggttt tttgtttctc agtctgcttt agcttttaac 1560 tctggaagcg catgcacact gaactctgct cagtgctaaa cagtcaccag caggttcctc 1620 agggtttcag ccctaaaatg taaaacctgg ataatcagtg tatgttgcac cagaatcaac 1680 attttttttt taactgcaaa aaatgatggt ctcatctctg aatttatatt tctcattctt 1740 ttgaacatac tatagctaat atattttatg ttgctaaatt gcttctatct agcatgttaa 1800 acaaagataa tatactttcg atgaaagtaa attataggaa aaaaattaac tgttttaaaa 1860 agaacttgat tatgttttat gatttcaggc aagtattcat ttttaacttg ctacctactt 1920 ttaaataaat gtttacattt ctaaataaaa 1950 <210> 204 <211> 532 <212> DNA <213> Homo sapiens <400> 204 gaataataat tactagcaac gtttattcaa aactaaaata actgatctcc ttttattttg 60 tatcttccat aggaattcct ttcctacaag aaacctaaaa tgagagagtt ttttattgga 120 ctgtcagacc aggttgtcga gggtcagtgg caatgggtgg acggcacacc tttgacaaag 180 tctctgagct tctgggatgt aggggagccc aacaacatag ctaccctgga ggactgtgcc 240 accatgagag actcttcaaa cccaaggcaa aattggaatg atgtaacctg tttcctcaat 300 tattttcgga tttgtgaaat ggtaggaata aatcctttga acaaaggaaa atctctttaa 360 gaacagaagg cacaactcaa atgtgtaaag aaggaagagc aagaacatgg ccacacccac 420 cgccccacac gagaaatttg tgcgctgaac ttcaaaggac ttcataagta tttgttactc 480 tgatataaat aaaaataagt agttttaaat gttataaaaa aaaaaaaaag gg 532 <210> 205 <211> 4851 <212> DNA <213> Homo sapiens <400> 205 tctatttctt cttcattaat tctccatcta gtcttgtgan aaaaaaaaaa aaaaccctca 60 gagatagtct ttgtgaagag cttctgacag aatcactgag taccttcctt cccccagatg 120 aggaagacaa gggggtctca gtgtctgtgc tgtctcctct tctcttcccc aaccaaggac 180 tgtgccatta ctgcccgtct caactgtcca tgcaggagga cagagttgcc tggtactctt 240 acccttgtcc ctctcctaaa gggagcacaa ggaaactgaa gagactgaaa aagaagagag 300 tttgtagctg aaaaagaata gggatagcaa ggaaacccag aactgcattc ccctaagtgg 360 ggccatccca tgtgattgaa ttgtccatag cttgcctatg gtgagaaatg tgcatgctcc 420 gtgagctggt ctcttgaaac aggacttatg cttcctctat attctggtta aattttccaa 480 acacataagt tcactgagca cagatttctt atccagagac aagtagaatc taaccgcaga 540 ctgttggcag agtttccagg cacttagcca tgttcccttc ctgactcaaa tccccaaagg 600 ccttcactct cactgagaat cacactactg tcccatagat aaggcaggca ttgaagcacc 660 tgtcgtgatc ctctaggggg gagaatgaaa ggttatttcc tgcattgcat catcatagct 720 tttaatataa tgctacagaa tcatatccac attaggttag agttcagata tttggatatg 780 aatacctaac ctagccatat ccatggccat ctctgttctt ttcagcaatg ttttccatat 840 tatattagca atgacagaaa cagaacaagc caagatccag tcagttcttg ggagcttgtc 900 tagagcacca agtaatgaaa tagccaggta gtgggatgac tgtaccttta aaaatacata 960 atttagtttg caagctatat tatgctactt tctattttcc ttgttacttt atagcaattc 1020 attttaccct cacaaagtca atttagaacc ttatcattaa ctgggatgtg tagtgatatt 1080 tttgggcctc tgggtttcat gtgtcaatac aaggaatatt tatttaaaat agatttattt 1140 agaggaggca cagtgttgtt gatctgtgtg acaccaccca tatttttaaa aacctttgta 1200 tgtttctcta aatttgttgt tgactgaata taatagaccc taccataatt cgtcaaatat 1260 cactgattag ttacatcctt tgtgtgagat tagctgtaaa gtatactgct cttattctta 1320 ttcagaatag ttaattggta gccaaaaata catgtatcac agatgttagg tcgaatttaa 1380 acagcacagt caagtgctat ggaagttttt ctgctaaatt agtagattaa agaatactat 1440 accctaggca tggggagcag cacgttttcc tttggtaggt aggatctcta tactagtgaa 1500 cagtgccagt tccacacttt ggacttagaa ctgttctcta gttattgtaa cacagaatac 1560 tgtcaatccc taatttactt aatgttactt attggaagtg gggctgatga aatacgcaca 1620 ggagggaaat ctactgtgtt taggcacagg cagccccagt gtataaggag atcatattcc 1680 aaaaggttgt cagttggttg tttgcaacct ggaatgtatt ttcctttaga gaccaggtta 1740 tccatggtgg ttaggcccct agagcagctg gaaaagatga tcaaaccaat aggttagctg 1800 acatcgaata atgtaatagg tttgctaaag aatctaacca tcaaatataa tattgtttcc 1860 agggagggtg tttgttcaga gttgcctgtt agtagaatct ggactgtcca tcccagccac 1920 atcccaccta ctggacagta ggggtagaga tgccaccaga ctacaggtga ccagattggc 1980 ctgaaacatg gtgtccagta aaaacgggga ggaataagtc catgactgcc ggagagcttg 2040 gtggtaggag gagggtgaag gagggtgagg gggcctctca tgggtcagaa acctccaggg 2100 acatccctca gctggtaact ctgctgttgt ccggagggtt caggcttggt gtgccttctt 2160 ctgtttgtct gacttttggc tcctatggtt catctcctgc cctgcccacc acagaaaagg 2220 atgctgctgc acagcttctc caatgtacca gtcattgagg ccagcgcgca gcacttttaa 2280 tgtttttagt gctagtaact gtgttttaac tctccaggaa taagctggga ggttagaaaa 2340 caagaaaaaa gggggaaaaa aaaacctctc cacccacttt ccttttttac agttacagac 2400 cctgttgaga aaaagaagca cccagatggg tgatggtgat agggcttgtg gtggacacag 2460 ggttgtggta agattcctca gtgcttcggc gagcacctaa gactattacc ctggaactga 2520 ctgctttcta gagcttgatt catgcctcta agcnnnnnnn nnnnnnnnnn nnnnnnnnnn 2580 nnnnnnnnnn nnnnnnnnnn nnnnnnctca ttagaatgca gattctcagc cccctcccga 2640 catggtgaag tcagaagctc tcagggaggg actcagcaaa tgattctaaa gcgcatcaag 2700 tttgagaacc accctaagcc aatgagtctc ccttttactt cccattagtc ctccctcacc 2760 agatgattcc taggactcat ggtgcaacat acaggagcca ggctttaggg aggggaggaa 2820 aggagcctgg cggcaggggt ctctgcaatg gcaagaaagt gagtgaatcc agcgctgcca 2880 cctggttatc cccttctcgt tgaaaatagc agcgcgggtg caaattccta aacacaggct 2940 gcctgcactc ggtgttacct cgggctgagg catgataata ttttattttt taaagctgtg 3000 aggaaatgaa agtgaggctt tggttggggc gaggcagttg tgaaagaaat taaaataaaa 3060 gaccctttgt aaatgcagac ttagaagaaa tactgaattt gtgtcagaag ttctccagtg 3120 tttgtgttaa tcgtgtggtg ataatcctgt cctcctttta aagcgaattc tctactgaaa 3180 ggtctgctct gcttaaggag ctacaaactg ctctcaaaag aatgaaatac tgagttccaa 3240 ttcagtgagg cacagtgttg gactatggca catttagttg gagtcggggg gaggtcagga 3300 atatgatcag ataatggatt ttatacctta gagcaaaatc tattagtctc tctcagttta 3360 tcaatttaaa tggctttagg cttatagggg gtgtaaactt taagaatata attctcccat 3420 tcaagtttac agcaaacatc tagccacctt caaaacaaag aatatacaga ccatcattta 3480 gcaatactaa tacatgattt tccttgggga tggcaggttt gagaatcctt tagcaacagg 3540 acatacttcc cctaaattac agtgaattat ttataacgag ataaagcttt caggtacaag 3600 ctgaaggtgg ggtgtctaac aactaaaaac tatcactaaa tctcaaagag aaagttcttg 3660 caaaatatgt aaagttcaca aggtgcagac attttccttc tttaggcttt tatctaagga 3720 agggctatga aactgggccc atctgtatac aggctcaaat ttacgttttt aaaggaagaa 3780 tctatgcagc tgaggcttat tgcaggaaat acttcatttg tatgtaaata ttattgtaaa 3840 taaataggag gctgtatatt tttgaagttg ttgatccgca ctgaaataga agtctctagg 3900 atctgcatat aaacaataaa tgtttcctag aaattagtgg ttttgtttgg gaattagaaa 3960 aatttacatt ctctcccagg taacatagtt ctctcaatgt aaacttggaa cctgaaaccc 4020 tacttaattt agagaaagaa atgtctgaga aatagttccc ttgatttctt atgctggcat 4080 taagatcaat tatttaacag atagtcctct gagatacaag taaggaatat ttagacacaa 4140 atccttgtcc tatagaaaca gatataccca aatgacaaat tgtttcttca taatgatctt 4200 ccatttttaa cactgatacc actacacagt acatatgaaa acagaagctg gggagaagaa 4260 tgtttttttc acaattgaat tgctgcattt ctcaaacttt gggatctatg aaagcgggga 4320 gagggaacct gaatattaat tatgagcaca aatttgaagg aaagaaaaca aagaaccatt 4380 atctaatcaa gctttgaaag tcctgcatgt ttgcctttta ttttagtgtt gacgccaaca 4440 tagactgtct aaggtatttt tttccccaaa cacttgaatc ttggtcgttg gtatgtaatc 4500 cactctctag agtccagtgt actttagact tcatctgagt ccaatacatg taccacacta 4560 ctgttttatt aatgtaaaaa ccttgtaaat gaatttcaga tgggtgattt aagtgagtca 4620 caagtcacaa aactttgcta ttcatagtta atcaaataga actgggtttt ttttttcaga 4680 gtgtggtgta aataaagaaa tataagaagt tctgttctat aactgctctg ttaacatagt 4740 ttttaaacat taaaaaatgt gaactaaaag taaaaggaaa aaaaatctat gtcgggtgcg 4800 gagaaagagg taatgaaatg gcaggaattc gatatcagct tatcataccg t 4851 <210> 206 <211> 5387 <212> DNA <213> Homo sapiens <400> 206 atttggtaat gctgcacaga aattttcaat tggagattcc acagtaagcg ttttttttct 60 ttgaagattt atgatgcact tattcaatag ctgtcagccg ttccaccctt ttgaccgtac 120 acattctatt acaatgaatt ttgcagtttt gcacattttt taaatgtcat taactgttag 180 ggaattttac ttgaatactg aatacatata atgtttatat taaaaaggac atttgtgtta 240 aaaaggaaat tagagttgca gtaaactttc aatgctgcac acaaaaaaaa gacatttgat 300 ttttcagtag aaattgtcct acatgtgctt tattgatttg ctattgaaag aatagggttt 360 tttgnnnnnn nnnnnnnnnn nnnnnnnnta aatgtgcagt gttgaatcat ttcttcatag 420 tgctcccccg agttgggact agggcttcaa tttcacttct taaaaaaaat catcatatat 480 ttgatatgcc cagactgcat acgattttaa gcggagtaca actactattg taaagctaat 540 gtgaagatat tattaaaaag gttttttttt ccagaaattt ggtgtcttca aattatacct 600 tcaccttgac atttgaatat ccagccattt tgtttcttaa tggtataaaa ttccattttc 660 aataacttat tggtgctgaa attgttcact agctgtggtc tgacctagtt aatttacaaa 720 tacagattga ataggaccta ctagagcagc atttatagag tttgatggca aatagattag 780 gcagaacttc atctaaaata ttcttagtaa ataatgttga cacgttttcc ataccttgtc 840 agtttcattc aacaattttt aaatttttaa caaagctctt aggatttaca catttatatt 900 taaacattga tatatagagt attgattgat tgctcataag ttaaattggt aaagttagag 960 acaactattc taacacctca ccattgaaat ttatatgcca ccttgtcttt cataaaagct 1020 gaaaattgtt acctaaaatg aaaatcaact tcatgttttg aagatagtta taaatattgt 1080 tctttgttac aatttcgggc accgcatatt aaaacgtaac tttattgttc caatatgtaa 1140 catggagggc caggtcataa ataatgacat tataatgggc ttttgcactg ttattatttt 1200 tcctttggaa tgtgaaggtc tgaatgaggg ttttgatttt gaatgtttca atgtttttga 1260 gaagccttgc ttacatttta tggtgtagtc attggaaatg gaaaaatggc attatatata 1320 ttatatatat aaatatatat tatacatact ctccttactt tatttcagtt accatcccca 1380 tagaatttga caagaattgc tatgactgaa aggttttcga gtcctaatta aaactttatt 1440 tatggcagta ttcataatta gcctgaaatg cattctgtag gtaatctctg agtttctgga 1500 atattttctt agactttttg gatgtgcagc agcttacatg tctgaagtta cttgaaggca 1560 tcacttttaa gaaagcttac agttgggccc tgtaccatcc caagtccttt gtagctcctc 1620 ttgaacatgt ttgccatact tttaaaaggg tagttgaata aatagcatca ccattctttg 1680 ctgtggcaca ggttataaac ttaagtggag tttaccggca gcatcaaatg tttcagcttt 1740 aaaaaataaa agtagggtac aagtttaatg tttagttcta gaaattttgt gcaatatgtt 1800 cataacgatg gctgtggttg ccacaaagtg cctcgtttac ctttaaatac tgttaatgtg 1860 tcatgcatgc agatggaagg ggtggaactg tgcactaaag tgggggcttt aactgtagta 1920 tttggcagag ttgccttcta cctgccagtt caaaagttca acctgttttc atatagaata 1980 tatatactaa aaaatttcag tctgttaaac agccttactc tgattcagcc tcttcagata 2040 ctcttgtgct gtgcagcagt ggctctgtgt gtaaatgcta tgcactgagg atacacaaaa 2100 ataccaatat gatgtgtaca ggataatgcc tcatcccaat cagatgtcca tttgttattg 2160 tgtttgttaa caacccttta tctcttagtg ttataaactc cacttaaaac tgattaaagt 2220 ctcattcttg tcattgtgtg ggtgttttat taaatgagag tttataattc aaattgctta 2280 agtccattga agttttaatt aatgggcagc caaatgtgaa tacaaagttt tcagtttttt 2340 tttttcctgc tgtccttcaa agcctacnnn nnnnnnnnnn nnnnnnnnnn nnnnntggcc 2400 tgagagtaga gtatctgtct actcatgttt aattaaggaa aaacacttat ttttagggct 2460 ttagtcatca cttcataaat tgtataagca cattaaatag cgttctagtc ctgaaaaagt 2520 ccaagattct tagaaaattg tgcatatttt tattatgaca gatgtttgaa gataattccc 2580 cagaatggat ttgatacttt agatttcaat tttgtggctt ttgtctatta ttctgtactc 2640 tgccatcagc atatggaaag cttcatttac tcatcatgac ttgtgccata taaaaattga 2700 tatttcggaa tagtctaaag gactttttgt acttgaattt aatcatgttg tttctaatat 2760 tcttaaaagc ttgaagacta aagcatatcc tttcaacaaa gcatagtaag gtaataagaa 2820 agtgtagttt gtacaagtgt taaaaaaata aagtagacaa tgttacagtg ggacttatta 2880 tttcaagttt acattttctc catgtaattt tttaaaaagt aaatgaaaaa atgtgcaata 2940 atgtaaaata tgaagtgtat gtgtacacac attttatttt tcggtatctt gggtatacgt 3000 atggttgaaa actatactgg agtctaaaag tattctaatt tataagaaga cattttggtg 3060 atgtttgaaa aatagaaatg tgctagtttt gtttttatat catgtccttt gtacgttgta 3120 atatgagctg gcttggttca gtaaatgcca tcaccatttc cattgagaat ttaaaactca 3180 ccagtgttta atatgcaggc ttccaaaggc ttatgaaaaa aatcaagacc cttaaatcta 3240 gttaatttgc tgctaacatg aaactctttg gttcttttat ttttgccaga taattagaca 3300 cacatctaaa gcttagtctt aaatggctta agtgtagcta ttgattagtg ctgttgctag 3360 ttcagaaaga aatgtttgtg aatggaaaca agaatattca gtccaaactg ttgtaaggac 3420 agtacctgaa aaccaggaaa caggataatg gaaaaagtct tttaaagatg aaatgttgga 3480 gccaactttc ttatagaatt aattgtatgt ggctatagaa agcctaatga ttgttgctta 3540 tttttgagag catattattc ttttatgacc ataatcttgc tgtttttcca tcttccaaaa 3600 gatcttcctt ctaatatgta tatcagaatg tgggtagcca gtcagacaaa ttcatattgg 3660 ttggtagctt taaaaagttt gtaatgtgaa gacaggaaag gacaaaatag tttgctttgg 3720 tggtagtact ctggttgtta agctaggtat tttgagacta cttccccatc acaacaacaa 3780 taaaataatc actcataatc ctatcacctg gagacatagc catcgttaat atgttagtga 3840 ctatacaatc atgttttctt ctgtatatcc atgtatattc tttaaaaatg aaatttatac 3900 tgtacctgat ctcaaagctt tttagcttag tatatctgtc atgaatttgt aggatgttcc 3960 attgcatcag aaaacggaca gtgatttgat tactttctaa tgccacagat gcagattaca 4020 tgtagttatt gagaatcctt tcgaattcag tggcttaatc atgaatgtct aaatattgtt 4080 gacattagga tgatacatgt aaattaaagt tacatttgtt tagcatagac aagcttaaca 4140 ttgtagatgt ttctcttcaa aaatcatctt aaacatttgc atttggaatt gtgttaaata 4200 gaatgtgtga aacactgtat tagtaaactt catcaccttt ctacttcctt atagtttgaa 4260 cttttcagtt tttgtagttc ccaaacagtt gctcaattta gagcaaatta atttaacacc 4320 tgccaaaaaa aggctgctgt tggcttatca gttgtcttta aattcaaatg ctcatgtgac 4380 ttttatcaca tcaaaaaata tttcattaat gattcacctt tagctctgaa aattaccgcg 4440 tttagtaatt atagtgggct tataaaaaca tgcaactctt tttgatagtt atttgagaat 4500 tttggtgaaa aatatttagc tgagggcagt atagaactta taaaccaata tattgatatt 4560 tttaaaacat ttttacatat aagtaaactg ccatctttga gcataactac atttaaaaat 4620 aaagctgcat atttttaaat caagtgttta acaagaattt atatttttta ttttttaaaa 4680 ttaaaaataa tttatatttc ctctgttgca tgaggattct catctgtgct tataatggtt 4740 agagatttta tttgtgtgga atgaagtgag gcttgtagtc atggttctag tgtttcagtt 4800 tgccaagtct gtttactgca gtgaaattca tcaaatgttt cagtgtggtt ttctgtagcc 4860 tatcatttac tggctatttt tttatgtaca cctttaggat tttctgccta ctctatccag 4920 ttgtccaaat gatatcctac attttacaaa tgccctttca gtttctattt tctttttcca 4980 ttaaattgcc ctcatgtcct aatgtgcann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5040 nnnnnnnnnn nattttcaag agtgctagac ttccaatttg agagattaaa taatttaatt 5100 caggcaaaca tttttcattg gaatttcaca gttcattgta atgaaaatgt taatcctgga 5160 tgacctttga catacagtaa tgaatcttgg atattaatga atttgttagt agcatcttga 5220 tgtgtgtttt aatgagttat tttcaaagtt gtgcattaaa ccaaagttgg catactggaa 5280 gtgtttatat caagttccat ttggctactg atggacaaaa aatagaaatg ccttcctatg 5340 gagagtattt ttcctttaaa aaattaaaaa ggttaattat tttgact 5387 <210> 207 <211> 247 <212> DNA <213> Homo sapiens <400> 207 agaaagtaag cccccccaaa acaggggcaa tgttttttgt atgttttatt gggcctagga 60 ccccgtaaaa gccccataaa aatttattat ggggggccgt gagtttttat tataaggggg 120 agaaactgaa atccccaacc ctgttttgtt gcttgttttt ttatgacccc caatttaatt 180 ggggaaaatt ggcccctttt aaaaattgtc cccaatattt ccttccaata aaagggccat 240 ggggaac 247 <210> 208 <211> 565 <212> DNA <213> Homo sapiens <400> 208 cagtgcaaaa acatactgat aacagtgact tntagtctgt antcatttga gttctgtgcc 60 cttttttctg tgcacattgt acttctattt ttgtccagta aaactttaag aaaacccaga 120 agttgctaca aatgataaag ataaggtttt gtttctctca aaaaggttgt tatatgctgc 180 tgttccagga catatcagga tgacaactat gtataatatt taaagccaca tctttagtag 240 gttcacagat actttatata ctataaaaag tatgactgtg tatatattcc taatgcttat 300 gtaagatgtt cgtttagaga tataaaataa tatctagtat gatagaaaac agtttagatt 360 aaacatgaaa tacagtttac ttgtaattca ctttgttctt tattttttta agggaccagt 420 tactctccac aagaaaattc acacaaccac agtgctcttc atagttcaaa ttcacattct 480 tctaatccaa gcaataaccc aagcaaaact tcagatgcag taagtattat aaacatgtcc 540 aatatggttt cttggaattt tttgc 565 <210> 209 <211> 3756 <212> DNA <213> Homo sapiens <400> 209 gctatttctc catttcagag aaaaaagccc ttattggtct gtgcatttca aggccattca 60 caaattccat ttgctgctca tcacactaag atgcattctc taatcactct gaaatgcctg 120 cttgttgagg ctgtctctta attaaggaat aaggttgcct caatcattaa ggagccaaat 180 tcttacaaac atcatcatca taactctttg tacttccacg gaactttttc tccaaggagt 240 tttgggccat tcacgctaag cccatcccat tgtcttcctc catgctagtc tccttagaaa 300 tcagtggata cttggtgagg gcaccaagta tccactaacg tttcttagct tctctgtgtg 360 tgtgcccatt cataggcaga tcctggactc tgtctctagg agattaaatt taaaagatgc 420 tgggtcctaa agctcgaccc agcatcattt aaactggacc gtgtcaatct ggggggactg 480 gattgtgagt gggatgattg taaccagaag ccatagcaaa gggtggacta gccgcctaaa 540 catagaaaga gcagggcttc cttctgcgtt tcacgggctg cactgacttc atctgctcct 600 gtggtgtggg ctcagtgcgg gagtctctac agtcccagca tgagtgggaa atgggtggca 660 agtggccctc cctgttttga tgagagacct tggagggaac agaagtgccc ttgtctcggt 720 tgtaggtttc tgtccccttt ccagagccag tgtaaccacc tccaccacag atagagattg 780 gcccagtgtc actgggtgtt ggctcctcgg tcaatctgga ttttaatggt tcctactctt 840 tctcccctca gggcccccat gctgcttggg ccttgtgcca gttgaagagg tggacagtcc 900 tgactcctgc caagtgagtg gaggagactg gtgtccccag caccccgtag gggcctacgt 960 aggacaggaa cctggaatgc agctctcccc ggggccactg gtgcgtgtgt cttttgaaac 1020 accacctctc acaatttagg cagaagctga tatcccagaa agactatata ttgnnnnnnn 1080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnca gagaaaattg gtatttattt ttctattata 1140 gccatattta tatatttatg cacttgtaaa taaatgtata tgttttataa ttctggagag 1200 acataaggag tcctacccgt tgaggttgga gagggaaaat aaagaagctg ccacctaaca 1260 ggagtcaccc aggaaagcac cgcacaggct ggcgcgggac agactcctaa cctggggcct 1320 ctgcagtggc aggcgaggct gcaggaggcc cacagataag ctggcaagag gaaggatccc 1380 aggcacatgg ttcatcacga gcatgaggga acagcaaggg gcacggtatc acagcctgga 1440 gacacccaca cagatggctg gatccggtgc tacgggaaac attttcctaa gatgcccatg 1500 agaacagacc aagatgtgta cagcactatg agcattaaaa aaccttccag aatcaataat 1560 ccgtggcaac atatctctgt aaaaacaaac actgtaactt ctaaataaat gtttagtctt 1620 ccctgtaacc ttcaaactga gtcatgtgtg agtcagcatt ttctttacat gttagaattc 1680 agtctctgag tatttgaaga aaatacccac ttacaatatt ttcaggtcca tcagaaatga 1740 gatctgaaaa aggtagtaaa tgtttctctt ttttgttttt taaaacagtg aatgtcagtt 1800 gtgcttggat tcatgcagaa cacattaccg tttagtccac aagggaaccg ttgtacaaca 1860 gaccaggaaa aacaggttca tagttctctt accaactgga cttgagatga agtttaggtc 1920 atattgaaga aatagaacta atctttttta tataggtgtg tgttgaagac caaatatttt 1980 ctccaaaata ctgtttagct aagtgctgtg ccacacatgg acatatggtg cataataaat 2040 tcacttccct tctttccaaa gatacaccaa cattgccaga gtagttgact cactagttta 2100 aaatcaacat ttacttactg ttgtccaacc aaaggatcaa ccatagattc ttttttaatt 2160 gaaattttaa aatctttata tgtggaagtg gaattagatg gagactgatg cttgcaatga 2220 aagccttact acgctttgtg ttttggggct ggagagggtg gggggagcct gtattttcta 2280 gatttctgta aaattgagtt acagatgaaa tgccacttga gacaatctcg ttaagtgggg 2340 ggccagaccc tggcttttaa acatgaagaa tttgataaac agggtcctag ggaagagtca 2400 ctctgactgt ttagggcaag tgcatcctct gctggccaaa ataagtatag cacctgctat 2460 tcctgacttc tgcatccttt ttccatcaag ctcaacgtca gagagaactt catgtggaag 2520 tgcagcatgg ttttcaggaa agcagtattt taaaaatatt atttaaaagg aaggactgta 2580 aggaacaggt aaatgttagg aaatgagaag cagagcaggg aagagaagag aaaaaataag 2640 atactgtgat ttcagacaac ctggcatcac ggcccagagc tcacttctgg ggtgggtagg 2700 gctgacgctc tcagtcattg ctttgctatc cagaggcccc ccaatctgag ctgtaactca 2760 ccttctagcc ccactggttt ttacattttt tcctttttct ccttgatgat ctaaggtagc 2820 tgtcaaaatg aattctggtg aacttttctg aagtgatagg tgaaacatct gctttctgca 2880 cagcactgga atcatagcac tcaatggatt tagctctaaa gagaaattta gcgcatggct 2940 cacagacctc cctaagctgg ggagcccgct gtggtgggac aggctggctg gcaggcatga 3000 gcaactcctt tactctgaag ttgtgacaga ggggctggac tctgtggttt ctttttcttc 3060 caatgctgag attgatcatc ggtgatacta tggatgacag ttcagaagag ccaagttata 3120 tgaacaattg acccacaagt aactcagtgt aggctgattt ttggccttac cctcagaggt 3180 gaggctgctc ctctgggagc acagcagaag gcagggaagt gtgccaggag caggatagct 3240 tcccagccac cctgcccatg ccacaccctg ctggtctact tgtgtttgaa gcttaacttc 3300 ccaaagactc agatgctcta acttaactac agatttaaga ctaagcctgg aatcaagttg 3360 aaatgaacct aaagctatca acatattttg tccaattcaa aataaagtaa ttcagtgtta 3420 actgtcgtca attcccaaac atgcggaatg aagccctgaa tattgtagaa ttaactagtg 3480 atttagtcca gctcagtttg ggaataatta tcccgattag ctttcctctc agttgaaatg 3540 cacagcaagt cctgatgtgg ctcttctgta gactgtaggt ccattcttgc tgcaatcaga 3600 atcagaatct cagaatggga aggaacccat tctaccaatc cttcatttgt cagataataa 3660 aatgaggccc aggaagataa cgtaacttct cctgattctc tacaattacc aaggggatgg 3720 tatcgcctca agacctttct cagagaccag ccactc 3756 <210> 210 <211> 3789 <212> DNA <213> Homo sapiens <400> 210 aggcggcggc gggcccaagg cgtgaggcgc cgcccgggtg tccccgcggc gcaggaggcg 60 gtggagcgca gagcgggcga gcgcgaaaaa tcactaccaa tataatggat tttatatatc 120 agattgcttt attctggata tcatggtaac aatacagaaa gtatacataa tttcccattt 180 ctgcaagtag tcatgactgc tgaagaaaga aaaacttaaa gctacggcag aattatttta 240 tggaaattct gattttgttt ttaatttttg ataacttttt actaaaggta tgaacacaca 300 aagagcttat tttgttaggc aaatacacat taataagaat gcctagaaga ggactgattc 360 ttcacacccg gacccactgg ttgctgttgg gccttgcttt gctctgcagt ttggtattat 420 ttatgtacct cctggaatgt gccccccaga ctgatggaaa tgcatctctt cctggtgttg 480 ttggggaaaa ttatggtaaa gagtattatc aagccctcct acaggaacaa gaagaacatt 540 atcagaccag ggcaaccagt ctgaaacgcc aaattgccca actaaaacaa gaattacaag 600 aaatgagtga gaagatgcgg tcactgcaag aaagaaggaa tgtaggggct aatggcatag 660 gctatcagag caacaaagag caagcaccta gtgatctttt agagtttctt cattcccaaa 720 ttgacaaagc tgaagttagc ataggggcca aactacccag tgagtatggg gtcattccct 780 ttgaaagttt taccttaatg aaagtatttc aattggaaat gggtctcact cgccatcctg 840 aagaaaagcc agttagaaaa gacaaacgag atgaattggt ggaagttatt gaagcgggct 900 tggaggtcat taataatcct gatgaagatg atgaacaaga agatgaggag ggtccccttg 960 gagagaaact gatatttaat gaaaatgact tcgtagaagg ttattatcgc actgagagag 1020 ataagggcac acagtatgaa ctctttttta agaaagcaga ccttacggaa tatagacatg 1080 tgaccctctt ccgccctttt ggacctctca tgaaagtgaa gagtgagatg attgacatca 1140 ctagatcaat tattaatatc attgtgccac ttgctgaaag aactgaagca tttgtacaat 1200 ttatgcagaa cttcagggat gtttgtattc atcaagacaa gaagattcat ctcacagtgg 1260 tgtattttgg taaagaagga ctgtctaaag tcaagtctat cctagaatct gtcaccagtg 1320 agtctaattt tcacaattac accttggtct cattgaatga agaatttaat cgtggacgag 1380 gactaaatgt gggtgcccga gcttgggaca agggagaggt cttgatgttt ttctgtgatg 1440 ttgatatcta tttctcagcc gaattcctta acagctgccg gttaaatgct gagccaggta 1500 agaaggtgtt ttaccctgtg gtgttcagtc tttacaatcc tgccattgtt tatgccaacc 1560 aggaagtgcc accacctgtg gagcagcagc tggttcacaa aaaggattct ggcttttggc 1620 gagattttgg ctttggaatg acttgtcagt atcgttcaga tttcctgacc attggtggat 1680 ttgacatgga agtgaaaggt tggggtggag aagatgttca tctttatcga aaatacttac 1740 atggtgacct cattgtgatt cggactccgg ttcctggtct tttccacctc tggcatgaaa 1800 agcgctgtgc tgatgagctg acccccgagc agtaccgcat gtgcatccag tctaaagcca 1860 tgaatgaggc ctctcactcc cacctgggaa tgctggtctt cagggaggaa atagagacgc 1920 atcttcataa acaggcatac aggacaaaca gtgaagctgt tggttgaaat cataattaat 1980 gcgttactgt atgaaccaca aaacagcact atttatttag ccttacttct acttccagat 2040 gcagtgcctc ttttggagaa gacatgttta tttttcatgt tctttctgac attactttag 2100 caattcaact tgatgtgaga agaaaaaaca aatgtttcaa cacaaaatct ctgttttgtg 2160 agaatactgc actatggaat aattgacaaa ttgaaatctc atatttgtcc caaaagttgt 2220 tttgagttag ttctacctgg tgcccatgtt ctgattgtgt gtgggattgc atggtgtcct 2280 gattgcatct aggtggagcg gatggaatgt gctgggccac tgttgggtgg agagcagcac 2340 attcttacag aggagatgga gcgttatgag catagtatgt ggataggtat cttcacctgc 2400 ccgcccctga gtcagcctcc ttgacttgat agcttgaaga atccttttcc actgaaatag 2460 aggataatta attgacacat ctgaaatccc caatcaatca atcaagagaa aggtagaact 2520 aaaaactcct taacttactg ttgcttacac ccctgaaagt ctgtttttaa gcaaatgggt 2580 aatagtagaa aataggttag aatctatggc ttgattaaaa atatgttatt acattatcat 2640 gttcaggatt aggattagta gtcagttgct gtaaactatt ttgaacaaac agaaaagaac 2700 acggaaacat ttttaacaga gcatttaatt atgttggaat acaggatcct agctctgtct 2760 gggaacatta gtttatgtga gccagctcta tcagggtctt cccatggtgg ttcagaatag 2820 atgagcatag catggttttg tttgtttttg ctttcaattt tctaatttgg catggatcca 2880 tatgtattta ctatcctttt tctaatatat taatatatgc tacatttgta tttgcattac 2940 tataatactt tgagttgaaa aagagtttca ttgtggagag aaaaagcaaa tggtatgcca 3000 caagatcact ctgatttgag aaaagggagg aggggaagat agtctgaatg gaaatctgaa 3060 atacggaatg ttttagagaa atatgtcact tgcatataga atgttttaat tgaggtataa 3120 attaatgaga caaagtgaaa aagaaattat attcagatag gactgcacta cattatttgt 3180 cacacatgga tctgttacca tcaggtcaat tcctagtatg cataaatttt ttaacccttt 3240 taaaagagac ctatgttgaa aacccctgaa aattcactga agaaaaatca ttactctttt 3300 tctcagtaaa tcatatcatc tgaaatatta caaatttcaa atttctaggt gctatattaa 3360 ttcaatatta caataactct tacctaatta ttcttacaag ttttaagttg tggtagttta 3420 gtgatttttt taaaagatgt gtgaaatgtt ctctgcaaaa taattcaggc cactgtctcc 3480 ttttatatat tattataatt atttattatg aagaccagtg aattacgata tttaaagtga 3540 gagaacttaa ttatttgcaa aggtaagtta cagcttgttt tttgagagaa tcaaatgagt 3600 ttacttttgt tcctgttgtt tttaactagc tttaagttta aagatggaag ctaagcaatg 3660 gaaatgctat acgtttttga catttattaa atggtaccaa taaagtattt tattaccaaa 3720 agttaaaaaa atctatgtcg ggtgcggaga aagaggtaat gaaatggcag gaattcgata 3780 tcagcttat 3789 <210> 211 <211> 3156 <212> DNA <213> Homo sapiens <400> 211 cttggaccat gtataatatg atgcttctaa tccaaaagag gaaaggcatt gggagtcagc 60 tccgtagagg gctcggagag gcagagggag acagaggagc tggtactgca gagcggtcgt 120 ctgattggct ggacggtcgt agctgggcta taaaagagac ccctacaggc ttagcaggaa 180 gacgctcaga ggattctgac aatatcttta ccggagaaga ggcaaagtac gctcaaagcc 240 gaagccacag ctcctcctgc cgcatttctt tcctgcttgc gaattccaag ctgttaaata 300 agatgtgcaa agggcttgca ggtctgccgg cttcttgctt gaggagtgca aaagatatga 360 aacatcggct aggtttcctg ctgcaaaaat ctgattcctg tgaacacaat tcttcccaca 420 acaagaagga caaagtggtt atttgccaga gagtgagcca agaggaagtc aagaaatggg 480 ctgaatcact ggaaaacctg attagtcatg aatgtgggct ggcagctttc aaagctttct 540 tgaagtctga atatagtgag gagaatattg acttctggat cagctgtgaa gagtacaaga 600 aaatcaaatc accatctaaa ctaagtccca aggccaaaaa gatctataat gaattcatct 660 cagtccaggc aaccaaagag gtgaacctgg attcttgcac cagggaagag acaagccgga 720 acatgctaga gcctacaata acctgctttg atgaggccca gaagaagatt ttcaacctga 780 tggagaagga ttcctaccgc cgcttcctca agtctcgatt ctatcttgat ttggtcaacc 840 cgtccagctg tggggcagaa aagcagaaag gagccaagag ttcagcagac tgtgcttccc 900 tggtccctca gtgtgcctaa ttctcacctg aaggcagagg gatgaaatgc caagactcta 960 tgctctggaa aacctgaggc caaatattga tctgtattaa gctccagtgc tttatccaca 1020 ttgtagccta atattcatgc tgcctgccat gtgtgagtca cttctacgca taaactagat 1080 atagcttttg gtgtttgagt gttcatcagg gtgggacccc attccagtcc aattttccta 1140 agtttctttg agggttccat gggagcaaat atctaaataa tggcctggta ggtctggatt 1200 ttcaaagatt gttggcagtt tcctcctccc aacagtttta cctcgggatg gttggttagt 1260 gcatgtcaca tgacatccac atgcacatgt attctgttgg ccagcacgtt ctccagactc 1320 tagatgttta gatgaggttg agctatgata tgtgcttgtg tgtatgtcta tgtgtatata 1380 ttatatatac attagacaca catatacatt atttctgtat atagatgtct gtgtatacat 1440 atgtatgtgt gagtgtatgt atacacacac acacacacac acacactttt gcaagagtga 1500 tgggaaagac cctaggtgct cataactaga gtatgtgtat gtacttacat gggtgttttg 1560 atctctgttc tttcatacta catttgaaca gggcaaaatg aactaactgc catgtaggct 1620 aagaaagaaa tgctaacctg tggaaagttg gttttgtaaa attccatgga tcttgctgga 1680 gaagcatcca aggaacttca tgcttgattt gaccactgac agcctccacc ttgagcacta 1740 ttctaaggag caaatacctt agctcccttg agctggtttt ctctgatggc acttttgagc 1800 tcctaagctg ccagccttcc cttcttttcc tgggtgctca gggcatgctt attagcagct 1860 gggttggtat ggagttggca gacaggatgt tcaacttaat gaagaaatac agctaaggcc 1920 ttgccagcaa cacctgccgt aagttactgg ctgagtgagg gcatagaagt taaaggttac 1980 tgtttttatc ctctatcctt ttttcctttc ctgatcaagg tgctcttctc attttttcct 2040 gagaacctta gccatcagat gaggctcctt agtttattgt ggttggttgt tttttcttta 2100 taatggctct gggctatatg cccatattta taaaccagca gcaggggaaa gattatattt 2160 tataagaggg aacaaatttt cacaatttga aaagcccaca taagttttct cttttaaggt 2220 agaatcttgt taatttcatt ccaaacatcg gggctaacag agactggagg catttctttt 2280 taggctctga gactaaatga gaggaaaaga aaagaaaaaa aaatgattgt ctaaccaatt 2340 gtgagaatta ctgtttgaaa cttttcaagg cacattgaaa tacttgaaaa cttctcattt 2400 atgttattta tgatgttatt ttgtacgtgt tattattatt atattgtttt ataaatggag 2460 gtacaggata tcacctgaat tattaatgaa tgcccaggaa gtaattttct tctcattctt 2520 ctaaaactac tgcctttcaa agtgcacaca cacgcgtcca catacactgc attcgttgct 2580 ccagtataaa ttacatgcat gagcaccttt ctggctttta agccaatata atgggctgca 2640 aaatgaagac accagagtgt atgcatacaa atctcactgt attaaagatg caggttttct 2700 aattgtaccc ttcttgtctc tctggcaatc ttgcccttaa tatccctgga gttcctcatc 2760 agtgtcattt tctgttatac acagttccac aattttgtct ctagttgact tcaaatgtgt 2820 aactttattg gtcttgccct attataattg tcatgacttt cagattgtat ctgaactcac 2880 agactgctgt cttactaata ggtctggaag gtcactctga atgagaagta aattatttta 2940 tgtaatacat ttttgagtgt gtttttcagt tgtatttccc tgttatttca tcactatttc 3000 caatggtgag cttgcctgct catgctccct ggacagaata ctccttcctt ttgcatgcct 3060 gtttctatca tgtgcttgat aggcctcaaa gctaatgctt ccagtgaaac acacgcatct 3120 taataataag ggtaaataaa cgctccatat gaaact 3156 <210> 212 <211> 1086 <212> DNA <213> Homo sapiens <400> 212 ctggtcacac cctctatgtt aactcatgcg accctcacca atgttcctgt gatgtagtca 60 gaaccatagc taacatttag ttcattctag gcaccaaggc atattctaaa tgttatatca 120 gcattgattc atttactnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnnga agttgttctg acagtttcca cacagtaagg caagaaatga 300 cttcctttta gtcctgctgt tttcctgggc tcactgtttg accacagaga agtggtctca 360 actctctggg tcttggtttg cctgtcttta aaatggggca gtaatcccag taggtggtga 420 ctcccacggg gctgacctct gaagtaactg ccctgttgcc tctgctgccc tttgaaccag 480 tgtacagtcg ccagataggg acccggtgaa cacctgattc caaacatgta ggatgggggt 540 cttgtccctc tttttatgtg gtttaattgc caagtgtcta aagcttaata tgccgtgcta 600 tgtaaatatt ttatggatat aactgtcata ttttgatgtc aacagagttt tagggataaa 660 atggtacccg gccaacatca agtgacttta tagctgcaag aaatgtggta tgtggagaag 720 ttctgtatgt gaggaaggaa aaaaagaaaa taaaagtgtg tttgaaaaat attatcttgg 780 gttctttgta aaatttattt tttacatgct gaattagcct cgatcttttt gattaagagc 840 acaaactttt ttttgtaaaa catgtaaaaa aaaaaactgg gattaatttt tagtgttgga 900 actgcctctt attttaggct gtagataaaa tagcattttt aggttagcca gtgtgactat 960 gcacctaatt ttttatgaga ttaaattcat aagacttaat ttgtacaata gtttgtgaaa 1020 tatcttgtta ctgcttttat ttagcagact gtggactgta ataaagtata taaattggtg 1080 aaatat 1086 <210> 213 <211> 6115 <212> DNA <213> Homo sapiens <400> 213 cccacaaact ggttgcattt gttgatttat ttttccatcc ttttcaccag taaagattat 60 catcgtttat ttttgttttt aaagttgaaa acaaaaaaga ggagagaaca gagttatggt 120 atgaatgtat gtaaaactat agagaactac agtaatatgt actgtggtta ttgctgtctt 180 cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ggtaggcaac 240 tcggaatctg aaggaatctt gtctgacaac tgtgctatcc atgtgggcta cggtgtgaca 300 gtggcggtag agaggatgga aaaataaatc aacaaactgg ttgcatttgt tgatttattt 360 ttccatcctt ttcaccagta aagattatca tcgtttattt ttgtttttaa agttgaaaac 420 aaaaaagagg agagaacaga gttatggtat gaatgtatgt aaaactatag agaactacag 480 taatatgtac tgtggttatt gctgtcttca aaaaaaataa gatgaaagat aaacaactac 540 aacatacaac gaaaacaacc ggtaggcaac tcggaatctg aaggaatctt gtctgacaac 600 tgtgctatcc atgtgggcta cggtgtgaca gtggcggtgg agaggagact ccggctggcg 660 accggggact ggtggagtgg ggtgagtggg cacagggaag ctggggtccc cttcccctcg 720 gaccctcccc accttccctt tccccatcca aaaggatttc aggagaggag gccagagtct 780 gtgaaatgac taaactatat actccattag aaaaccaaga aagtatgttt gaaatagaaa 840 caaaagccta agagaaaata aaaagtggag aaacagtgca atgtaattct tgcactttag 900 tggttttaaa aacacagaca gtacaaggcc caggttgctg gctggtgaaa cccctgtccc 960 tcgtccctcc tccactttgc aaaacggagc ctcctttctc ttggaagcca gacatatcct 1020 ctctgacgct atggggtttc ttctccttag agctcttctc tgaggttccc attctgggcc 1080 ggagccctct caggagtgag tggatgggtc cggggtactg tcccaccttg agggggggct 1140 tggcggttgc cgtggcagcc ctgtctcact aaccggtgcg tggcgggagc aggtggttga 1200 ggcccaccct ctaggggagg ccagccctgt gggggtacca tggaggccac agaggtggtg 1260 gtggggagat ggggtgggag agaaggggca tgatcagaaa agggcctccc tggacctcgt 1320 gcgcctgcct tcctcccctc atggggccag tgtccccagg cctgtctgtc taggcctggc 1380 tgtcaaagaa aggttccagt ctcttcctcc ccatgtgccc tgctttgcca ggtgggtcag 1440 ggcaggctgg aggaaggagg gtcagtcctg gctgggcttc cctatctcct ggcagtcgtg 1500 ggaaagacag aggcatcttc ctcactggcg gagtgaggca cgaatctaaa ggggatggga 1560 gagaccttct gtgggtgtga gcgtgggagt gggcagcact tagattcgga gccatggata 1620 gtccggagtc caaggtctct gggtgagcag acagtcggcc aaaggccagc ctggagtcaa 1680 agagaccaga cccctgctta gattgccata ctcgcaccat tccaaacctg cctccctcac 1740 accctgccat gggggaagag gtgccgtctt cctccagtgc ctcccttccc aggatctccc 1800 caccctgggc tcagccagaa ctcccatttg ggaggcttag ttccatgtgt ccatgaaggc 1860 ccagcttccc tggggagtga ccagctgccc aggagaaact cctgcatgca gaagagactc 1920 acaggtttgg gttcgcaggc acgaactttg gaaaccggaa gagtctggcg cacttacacc 1980 aggctctaat cccccacctg atggctggca gcaaagagcc aacgcaaggg gcagaagcct 2040 gctcaaagtc cagacacagt ccgtgaagag agagcccctc tcaagaatca ggtccaggct 2100 gggaggaatg tggggggagc ttgtagttcc tggctcagtc ttttctcagg ggagtggcac 2160 cccagtatcc acttggcaga tcctagttgg ataactgctc aagatgcaaa gggagaatgg 2220 gtggaaagaa cagtgacgtg gaagaggttt gggatactgg cctaagacat acagaaacgt 2280 gagttgggtt taggggacag ctgtgcagag agatggggca tgctgactcg gcaggtcaag 2340 tccttgtggc tgctggccct atcaggcccc tttgtctcat gaagattgag cacttctcct 2400 gtccccagcc aactgtcctg tcccggggca taggagatag cacccaagtg ctatagctat 2460 agggttccca tcagttgaaa cagatttgct ttttcgctat tcctcttcgt agccccaaat 2520 tcgttgttgg aggcggtctc cgctgtgtca tgccatgagc aaagagtgaa gagagctgtg 2580 tccacagcac gaaggggtct ccttggccag tgtccaagcc ccctttcctg gatatcttca 2640 gccttaaaga acagtcacaa ggccacccat tggttgagga agtcattgga gaatgggagt 2700 ttcggaatct ggctgccgag tgacagcatc cctgaatcat gcgttccctg cttgtcccag 2760 ctttccttcc atcctccacc ccagggagga tgcagggact ggccagaatg gaggaagagc 2820 tggaaagact cgtgggcctc agtccctcgt tgcaggctga aggtgggcag cggagcgcat 2880 agtcttgtcc cttccaaagc atggccagtt tcgactgatt cttcctatct ggcttctaaa 2940 gtctagcacc ctcctaaagt tactcacctt ccctggctct gcggcctgga ttaagctcat 3000 ttctattttg caacccattc ccccattttc ctctctttcc tctcaaatcc cagaaaatac 3060 atatggtggg gaagctaagg aaatttctat tggcttttcc ccctttctgc tgctttgtgc 3120 caaagctaga atggaacagt cagccccctc tcccttcagc cctctgttcc tccccacatc 3180 gactctggcc ggaaccatcc atcttactgt tctcctgcat ctaaaccttt ttgccaccat 3240 ctccctctgc catctcttac ttcagtctcc ctcctgctct gccagcatgg agagtgaggg 3300 aggctgggag gaatgtgggg ggagcttgta gttcctggct cagtcttttc tcaggggagt 3360 ggcaccccag tatccacttg gcagatccta gttggataac tgctcaagat gcaaagggag 3420 aatgggtgga aagaacagtg acgtggaaga ggtttgggat actggcctaa gacatacaga 3480 aacgtgagtt gggtttaggg gacagctgtg cagagagatg gggcatgctg actcggcagg 3540 tcaaggcctt gtgactgttc tttaaggctg aagatatcca ggaaaggggg cttggacact 3600 ggccaaggag accccttcgt gctgtggaca cagctctctt cactctttgc tcatggcatg 3660 acacagcgga gaccgcctcc aacaacgaat ttggggctac gaagaggaat agcgaaaaag 3720 caaatctgtt tcaactgatg ggaaccctat agctatagaa cttgggggct atctcctatg 3780 cccctggaca ggacagttgg ctggggacag gagaagtgct caatcttcat gagacaaagg 3840 ggcccgatag ggccagcagc cacaaggcct tgacctgccg agtcagcatg ccccatctct 3900 ctgcacagct gtcccctaaa cccaactcac gtttctgtat gtcttaggcc agtatcccaa 3960 acctcttcca cgtcactgtt ctttccaccc attctccctt tgcatcttga gcagttatcc 4020 actaggatct gccaagtgga tactggggtg ccactcccct gagaaaagac tgagccagga 4080 actacaagct ccccccacat tcctcccagc ctggacctaa ttcttgagag gggctctctc 4140 ttcacggact gtgtctggac tttgagcagg cttctgcccc ttgcgttggc tctttgctgc 4200 cagccatcag gtgggggatt agagcctggt gtaagtgcgc cagactcttc cggtttccaa 4260 agttcgtgcc tgcgaaccca aacctgtgag tctcttctgc atgcaggagt ttctcctggg 4320 cagctggtca ctccccagag aagctgggcc ttcatggaca catggaacta agcctcccaa 4380 atgggagttc tggctgagcc cagggtgggg agatcctggg aagggaggca ctggaggaag 4440 acggcacctc cttcccccat tggcagggtg ctgagggagg ccaggtttgg aatggtgcga 4500 gtatggcaat ctaagcaggg gtctggtctc tttgactcca ggctggcctt tggccgactg 4560 tctgctcacc cagagacctt ggactccgga ctatccatgg ctccgaatct aagtgctgcc 4620 cactcccatg ctcacaccca cagaaggtct tcccatcccc tttagattcg tgcctcactc 4680 caccagtgag gaagatgcct ctgtctttcc cacgactgcc aggagatagg gaagcccagc 4740 caggactgac cctccttcct ccagcctgcc ctgacccacc tggcaaagca gggcacatgg 4800 ggaggaagag actggaacct ttctttgaca gccaggccta gacagacagg cctggggaca 4860 ctggccccat gaggggagga aggcaggcgc acgaggtcca gggaggccct tttctgatca 4920 tgccccttct ctcccacccc atctccccac caccacctct gtggcctcca tggtaccccc 4980 acagggctgg cctcccctag agggtgggcc tcaaccacct gctcccgcca cgcaccggtt 5040 agtgagacag ggctgccacg gcaaccgcca agcccccctc aaggtgggac agtaccccgg 5100 acccatccac tcactcctga gagggctccg gcccagaatg ggaacctcag agaagagctc 5160 taaggagaag aaaccccata gcgtcagaga ggatatgtct ggcttccaag agaaaggagg 5220 ctccgttttg caaagtggag gagggacgag ggacaggggt ttcaccagcc agcaacctgg 5280 gccttgtact gtctgtgttt ttaaaaccac taaagtgcaa gaattacatt gcactgtttc 5340 tccacttttt attttctctt aggcttttgt ttctatttca aacatacttt cttggttttc 5400 taatggagta tatagtttag tcatttcaca gactctggcc tcctctcctg aaatcctttt 5460 ggatggggaa agggaaggtg gggagggtcc gaggggaagg ggaccccagc ttccctgtgc 5520 ccgctcaccc cactccacca gtccccggtc gccagccgga gtctcctctc taccgccact 5580 gtcacaccgt agcccacatg gatagcacag ttgtcagaca agattccttc agattccgag 5640 ttgcctaccg gttgttttcg ttgttgtagt agttgttttt ctttttcttt ttttttttga 5700 agacagcaat aaccacagta catattactg tagttctcta tagttttaca tacattcata 5760 ccataactct gttctctcct cttttttgtt ttcaacttta aaaacaaaaa taaacgatga 5820 taatctttac tggtgaaaag gatggaaaaa taaatcaaca aatgcaacca gttttgtgag 5880 aaaaaaaaaa aaaagcgccg aaaaaaaaaa aaaacacctg aatgcggaag agctcggctc 5940 ctgtttagca ttttgtactt aaggaaataa aaaaccaaca aaggatctca cattttctta 6000 aaaagtgaag attgctgtat actatttatt caacttataa tttatgttac tccttgatct 6060 ttgtcttttg tcatgacaaa gcatttattt aataaagtta tgcattcagt taaaa 6115 <210> 214 <211> 5387 <212> DNA <213> Homo sapiens <400> 214 gcgcactgga gccctggcca gcgcgcagcc ttcccggcgc cggcgggctg ggtcttggga 60 attctggttg cttggctcac tcgcttttta caaaccactg gatcttacat gcctctgtac 120 cccccacttc cactccatgt ccccatgctc ctgcgccagc aacaggacat gttctctgga 180 tgtcagctga gtcattaaag taactctgca tgtcagtaga cagaccttgg tagaaccaca 240 aggctcccag agacacccat ctctcctcat ttttttggtg tgtgtgtctt caccgaacat 300 tcaaaactgt ttctccaaag cgttttgcaa aaactcagac tgttttccaa agcagaagca 360 ctggagtccc cagcagaagc gatgggcagt gtgcgaacca accgctacag catcgtctct 420 tcagaagaag acggtatgaa gttggccacc atggcagttg caaatggctt tgggaacggg 480 aagagtaaag tccacacccg acaacagtgc aggagccgct ttgtgaagaa agatggccac 540 tgtaatgttc agttcatcaa tgtgggtgag aaggggcaac ggtacctcgc agacatcttc 600 accacgtgtg tggacattcg ctggcggtgg atgctggtta tcttctgcct ggctttcgtc 660 ctgtcatggc tgttttttgg ctgtgtgttt tggttgatag ctctgctcca tggggacctg 720 gatgcatcca aagagggcaa agcttgtgtg tccgaggtca acagcttcac ggctgccttc 780 ctcttctcca ttgagaccca gacaaccata ggctatggtt tcagatgtgt cacggatgaa 840 tgcccaattg ctgttttcat ggtggtgttc cagtcaatcg tgggctgcat catcgatgct 900 ttcatcattg gcgcagtcat ggccaagatg gcaaagccaa agaagagaaa cgagactctt 960 gtcttcagtc acaatgccgt gattgccatg agagacggca agctgtgttt gatgtggcga 1020 gtgggcaatc ttcggaaaag ccacttggtg gaagctcatg ttcgagcaca gctcctcaaa 1080 tccagaatta cttctgaagg ggagtatatc cctctggatc aaatagacat caatgttggg 1140 tttgacagtg gaatcgatcg tatatttctg gtgtccccaa tcactatagt ccatgaaata 1200 gatgaagaca gtcctttata tgatttgagt aaacaggaca ttgacaacgc agactttgaa 1260 atcgtggtca tactggaagg catggtggaa gccactgcca tgacgacaca gtgccgtagc 1320 tcttatctag caaatgaaat cctgtggggc caccgctatg agcctgtgct ctttgaagag 1380 aagcactact acaaagtgga ctattccagg ttccacaaaa cttacgaagt ccccaacact 1440 cccctttgta gtgccagaga cttagcagaa aagaaatata tcctctcaaa tgcaaattca 1500 ttttgctatg aaaatgaagt tgccctcaca agcaaagagg aagacgacag tgaaaatgga 1560 gttccagaaa gcactagtac ggacacgccc cctgacatag accttcacaa ccaggcaagt 1620 gtacctctag agcccaggcc cttacggcga gagtcggaga tatgactgac tgattccttc 1680 tctggaatag ttactttaca acacggtctg ttggtcagag gccctaaaca gttatacaga 1740 tgacggtact ggtcaagatg ggtcaagcaa gcggccacaa gggactgagg caagcacaat 1800 ggtttcaaag aaagactgta agctccatga ttagcataaa gcactaacca tgtctccatg 1860 tgacccgatg gcacatagat gttgtagaat aagttatggg tttttatgtt ttgttttgtg 1920 tttttccaaa acttgaactt gcaggcaagc cttggttggg tatttgattt atccagaatg 1980 cttctcttta gggaacaagg atgtttttaa tggcataaca aaggcaagac tctgccttaa 2040 tttttgaaaa gctgctaact acatgaacac aaatgtgtat ttttgttgca gtgtagtttt 2100 ccttttgtgt aattttaaag tcagtgttga attttattga aagctcatga tgcgcttcaa 2160 agtggcaagt atttggctat taactgccaa aacaagagcc tgattttttg aggccagtaa 2220 ttcgtttgct agaattgatt ttttttctct ctctctttgt tacataaggg cattatgtaa 2280 cactagccga atggtagcct ctgggttgtt gtttttttct tttcctccat gatgttaatg 2340 ggttatctca aattttaagt taaactacct aaaataaata ccaaagataa tgcatatttt 2400 tgcacagtgg agcttacact taaaagaaaa caaagcccca tgggctgcct tgaaatcaag 2460 agacaataac tttgaacctc agcaagacct tgaaccgccg gttcattttg caccttattc 2520 agaaaataga gcatcatact caccgagtct agtcagtgta gtgcttttaa aaattttgtc 2580 ctttcatgta acttttttat tttaagagga agaagaagaa aggggcacac acacacaata 2640 ccgacgtcta tcctttcctg ctaggcagtg ctggccaggc tcatgtgtag tgtgcgagat 2700 ggtgatgtac tcttatattt ttctgggctt ttccttttgc acattccaaa attcatttca 2760 taagacaaga tcttcatagg acctccttgg catcctggca ttctcaaaac tgagccatcc 2820 agcatgaaag ataaatgggt ttaaaccctt gctgctgaat ttattgcctg gactgtcagg 2880 acatcaccag cccaccttca ccttagggaa gatgccacac ctggcctcca cacttgctct 2940 tctgatcagt ctgtctggat tgagtcctac agtgtcagat agggcggcaa atgccaaagc 3000 agggaaacag ggaggtgtgg acaagccagt ttgatgcagc acttcagatc aagtgcttag 3060 gaaggagagg aaacttgcct tttttatggc agaggatagt aatgaaaatg tctcagtatt 3120 ttagggtcaa tgagagccat aaaaatataa cataatcaca agtaaaggag ataatggtct 3180 aaaacagcta tttccctttt ctgtgtgcat acttatgact gaatgtgagc taagcatttt 3240 ctcctgtgga gccctagagc aggttactaa ggaaggacac attgttttcc agaagcctcc 3300 cctgcctggc tgactgcctt gctagaaaca taattttttt tttctcactg aagctcaata 3360 atggaacnnn nnnnnnnnnn nnnnnnnnnn naaagttccc tatttgtgaa ttctgggatt 3420 actgactttt ctttttaatt ggagtctcaa aatcaactct cttatggtat tatatctctg 3480 tatgccatta aaaaacagct tgttctagaa tcatgtattt tgtaaactga tgtttgtgat 3540 ggtctctggt tcttgaacag ccatatctga atgccgtgcc tgcaaaacta tgacaatttt 3600 tgctgttttc agccttcaga tttgatggct tgggaaactg aggtgttatt ttcaatgaaa 3660 caaagaaaga gatgttaagc aagtggttgt tttagatcca aatgtaaagg caggtttggg 3720 aaggtgttta aagagttgga ggaattgggg attgagttgt aaagaaaact tacagaagag 3780 gcaacaattt ggttcttgac agtgagagga tattgagggc ttcagctgct gctattatga 3840 tgttttgcaa aggaaaataa tcaaaccaaa gagtattcag tgatatgtaa attaaatgaa 3900 gatacagtgg agaatggggg tgaccacaaa agaggctccc cctaaacaca cagtgctgcc 3960 acttaaaaag acttgagaaa tttgaaaggg ggtgggtatg gggggggcaa gaaagaggga 4020 gggaaatctt tcaacttatt tctgaaaaag agaaaaaaat ataaaatttc tggtgcacag 4080 gtttgttttt tcaagaaaat tttgcagaag ctatgttttt aaagtgtaca ttttataaag 4140 tttatcagat attttcatat ttaaagccaa atgtaaatag aggtctgtaa agaaaaataa 4200 ttgccataga aagtataatt tcagtgcagt aatttctgag agctagtacc tatatgctac 4260 cggttagcat ggttttagca aatatatacc agccttataa ggttcgtatt gctatgttct 4320 tctgttattt atttcagcat ggactgttca tttgaaacct ttttctagtt attagcgttt 4380 taacagttac aagctttaaa tggcaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4440 nncaagagcc aagacacagg taatgcacga cattgattgc tgcattttac cttcaaaata 4500 tttgtcctta ttgactgggt ctccttaatt aatgtacaca tgtcattaga atgcagacgg 4560 aggggactca ccatgaatat ctggggttga ttcccagatg tgtgttgctt ctctattgca 4620 agcagattcc ctgttggatt tacttcggat ttattccctt ttaaagaatt tttgcccata 4680 tctggaaggg cactatattt ttgggaggag ccatagattc ctggttatcc tatttttaaa 4740 caaaatgtag acaaagtgaa ctctattttg attattgaga aaggagtagt tttctatccc 4800 tctaagagta tacttgaatc agacatttta aggatgtcac tatggcactg ttgtcatttc 4860 caaattccta gaaaagtttg ttttactttg tttttattct gttaatgcat tctttcttct 4920 ctttacttcc tttcttacca gtacactcct atctcaactc tgtttatttg atgagttctg 4980 tcccgtaaat catatttccc ttacaattaa taaatgtcac ttcatatttt ataataaacc 5040 actcagtaaa agcaaaagct tgtcctgaga agtagagtga gttctttttc actctgtgtc 5100 taataatgtt aaggtgggaa aaaaaaaagt gtggcatagc tacctgccca tccccaaccc 5160 tcagcaaagt agaatctctt ttctggtaat tttgggtttc cgctctgggc tctggcaagt 5220 tgaacaatcc tagccattga caatcgtgat agttattatt ttcccatttg ctgtcttttt 5280 gtatctaaag tcttcctatt gtactgcaca aaccatggat tgtacatatt tttatatatt 5340 atgtcttatt ttattatttc taaataaaaa aattaaaaat tgaaaac 5387 <210> 215 <211> 3190 <212> DNA <213> Homo sapiens <400> 215 ttttaccttg tatatgaact gctcttcaga tccacacttt gttgtttact gtgactctct 60 ttgttgaaaa gtacacttga actgcttttc aaatgtatat tacacctttg tttacatgtt 120 tgtacaccag cttccttacc ctgtggatcc taagataata tttggaaaga gaattgggga 180 ccgaaagatt tacacaccct gcgggaacaa tgtggtgact ggcttgtttc ccttgtgtct 240 tttctcagaa aaaccaagta atgagcacac tgctgagatg gaacacatga aatccttggt 300 tcacagacta tttacaatct tgcatttaga agagtctcag aaaaagagag agcaccattt 360 actggagaaa attgaccacc tgaaggaaca gctgcagccc cttgaacagg tgaaagctgg 420 aatagaagct cattcggaag ccaaaaccag tggactcctg tgggctggat tggcactgct 480 gtccattcag ggtggggcac tggcctggct cacgtggtgg gtgtactcct gggatatcat 540 ggagccagtt acatacttca tcacatttgc aaattctatg gtcttttttg catactttat 600 agtcactcga caggattata cttactcagc tgttaagagt aggcaatttc ttcagttctt 660 ccacaagaaa tcaaagcaac agcactttga tgtgcagcaa tacaacaagt taaaagaaga 720 ccttgctaag gctaaagaat ccctgaaaca ggcgcgtcat tctctctgtt tgcaaatgca 780 agtagaagaa ctcaatgaaa agaattaatc ttacagtttt aaatgtcgtc agattttcca 840 ttatgtattg attttgcaac ttaggatgtt tttgagtccc atggttcatt ttgattgttt 900 aatctttgtt attaaattct tgtaaaacag aagtattgtt tgaagttctc aactgagatt 960 tttacttttt ggatttttat gacttgctaa tgttagaaag ggcttgtatg cgtctatcaa 1020 agcaacggtg gctgctgtta gctaaaaatc cttgtcagct tgtcccacgt ttattctcta 1080 tgtggaggtg aaagggtctg tgcttggcat tcacttccat tcttagactt aatttggaat 1140 catcctttta aaaaaatcag agaccaggtc ttgccaaatc aaantcctgg gntcaagcaa 1200 ccctcctgcc tcaacctccc acagaatcgt cttgtcatta acttcttttt ttaatatgca 1260 gtagttggga gtaagatctt tttatcattt atcaaaaagg cataaatgtt ccaccaacca 1320 taaagtatag ttggtacttt ttgaacttca actgaaacag tgtatataaa cgattgcttt 1380 tgaacctgca aatcacaagt ttcaggtatc gaagccaaaa cagttaactt tcttcagcct 1440 ctggcagatt attaacaaaa cagtattatt cagattctat atcatattaa taagaattga 1500 accttgaaag taacatctgt tattctatta atgtgattgt gtgtgaatgg gtctgatgac 1560 tgttggactg tttgtaggaa cttaacatgg aagatgctga cagaatcaga ttttgcaggt 1620 gttcaaccta tagtggctaa gaattatgtt ttctatttca tcctcagaat gccatacaac 1680 aattctggaa tgctgatttt ttttaaagta ggaattaaag tcatacacaa aatgtggtaa 1740 ttcatatgta gatgaaatat taaacattta aatgaccgag taaaaaacat ctatcaatta 1800 cacaaatgaa caagaatgtg agttagaaaa atgtaataaa atatgaattt tgaatatttt 1860 attaagggat gatttaattc ctggatttca aaaaccttta aaaacatcaa acaataaact 1920 tttataaaaa agtgacaaaa tacaagttaa atcagctaga tttttgtgta accctgcagt 1980 ttattaaaaa ataatacaaa tgcttataaa tttttattta tctaatttcc tgaggatttt 2040 gtttctccat atcaaaccct ttcaccatgg ccaacatgaa cttttttttt ttaaggcagt 2100 tctctgctag gcattaaact ttaaaacatt tgaatcattg gaccataatg cttcacccta 2160 acgatattta tataaaagga agagaaagac annnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtgt 2520 aaaattagat agcctctatt aattaattag attttggaaa gaaatgcagc tttttagtta 2580 gcattgaggc aaaacaggga acctgcttct ttccaattgc acttgggtct ttgcaaaagt 2640 ccactcggcg ctgagaaact ttcctgttca ccagtgtgag gagttctgtg aactctaagg 2700 aggagccata ttttcccaac atctcacaca aatcttgaat gtaccatgag ccgttcacag 2760 tttcccggtg agaataatat ccttctgcaa cagagtaaaa catgaggaag tcagctccag 2820 caggcagcgt gtaaacggag gctgcatcca cctcagttat gttggtgtcc aacttctctg 2880 tctgattatc tactacatcc aaaggaatga ctggcacatc gtgctggttt ccccgacatg 2940 ccctgaatgg ataaatatct tgggttttcc aaccaggctg tgacacttgt ctcctttgaa 3000 caagccagtt aatgtctgaa tttcgatttt agcatcatat gcataaatgt gattgccttc 3060 gccatggctc aggaagacac acacaaagca atcggcatct gcgtggctaa cagttgacac 3120 tgccgggtgc cccctgcgga gccccgaggc cgagctcatt gcagccaaac gcgcagccag 3180 acaccttgcc 3190 <210> 216 <211> 2626 <212> DNA <213> Homo sapiens <400> 216 ggagatgtcc ccagaccggc cctgcccagc tggagaccag cagtgaggtc cagagcgagc 60 cagcagtccc caagccggag gatgacactc ctgtccagga cactaaaatg tgaagaacag 120 ctcattgtgc cccagtgatg aagttgctgg acacatctct ttgcaggtag cagcaacagt 180 tgtagcagca gcagacgaag ccattgcaga ggcagaatat gctgagtgtc tggagtcagc 240 ctgaagacac agggtggatt atttcctggc ctccacacca aacgttccct tgcagatgga 300 gactgaatct gagggcagca gacttttatc agcttgagtt tatgtcattt gatggacttg 360 gttcaacaac aagaacttac ttaaaacaat gtactgtggt gatgagtccc aggggcactg 420 gtcagcctgt ggagccctgg atgctatcca cacccaccta tccctgcagc taatttagct 480 gatctctaat ttaactgagc tctaatttag ctgatcagat tttgcttggg taaagttcct 540 ttttaatgtt ctaaagtgtt tacggttctc aaatatcagt taaaaactaa ttttaggtgg 600 ccataaacat aaaatagaaa ccctgtaagt tacagaagac cctaaattgt atcaaaaccc 660 tagagacaac ttttcaattt gatccaaatt tgaactggcc aaccagtctt taaaacactg 720 gactagaaga gataatgatt gaaacattta aaaaaaaaaa gtgctccatt cgcaggagct 780 tttcctgtcc tgtggttttc cagttggtga ccaccatggg aggtcgctgg ctcggctcac 840 tcccttctcc cacccttgag aatgtggaga actcccatgg agaggcagaa tggcaggagg 900 tttcatgtcc cgcgttgcat ctcctcctga aagaaaagca gtgatacctg aataatgctg 960 gctctccgat tgatcctgtg aggatgaatt tgcatttcca gaatccttga gcatggatta 1020 gatgtttcct gggaggtgcc ttgagtacca ttatgtgcaa gctacataat taaaacattt 1080 ttcttagttt ccctgggaag cttttcttga ctcacagccc aggttcttct gcccaacaca 1140 aaaggagtga gttggggtct ttagtctctt cttattgggt agctcttgct ttaatattct 1200 gtttggtgag tgtaagggat tctgcaaggg acagggggcc tgactaccca gtctttgact 1260 tgtatcctct cccctcttca tacactcctg ctgaaaaatg ttaatccaaa tacacattta 1320 aacttagggt cggtccttat tctgatttga gtattttaat gtctcagtgt gctgatttgg 1380 tagttggaag aattattctt ctggaggtct gttagactac atcctacact gacttcagaa 1440 aacagtctgt cagacaaaaa ggccttatgt caccactggt acctcagttt cctcatccca 1500 tttacagttt ttctaactcc agggtagtgt ttagtgttaa tatttgggat atattttttt 1560 tcaaaactgt ttttaagtag tttgtaattt gtaacaaact tgtaacctgg ttgggactga 1620 tattgtcata gctatgataa actttggata ttagcagaat ttgggagatg tgtgtgtcaa 1680 ttattttgag atctataaac tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tgctatcaat 1740 ctagctacca tccatttatt gacagagaag tctaccccta aacaatactt ggttttattt 1800 atatatgtct ttgggttgtt tatacacatg cactatctgg gcaagtactt tgtgaatatg 1860 tgcatgattg tgaatgtgtg atgaaaaggg ccactttact tgaggaaggc atggaacaga 1920 aagtatgggg tttagatatg aaaaatgaaa ctgcattttt cttctggagg gtctaaacat 1980 agtagcagac gagagagggg cagtaaaaat gacaagaatg tgacattgcg gcaccatgct 2040 tgtgggcatc agaatacctt tctatccccc aagtctcctg ttagtcacat tatttggtgt 2100 attttgtgaa aaaaatagag gccccattcc cagggcttgt tcattaataa agggggctct 2160 tggcagggaa ctcatgaagt acagggactg atttttgttg gtgctgcagc cccactgctt 2220 aaaactctcc tttctcaaag caaccatgat caggtgtttt atttgcatgg ttgatactgg 2280 aacttctaaa tttgggatta aagaaattca tctgtgtctt aggtagcaca aagttattaa 2340 caggccagga agaccttgtt tctttcaggc ttccataatg ggtttgaaag aaaacacgga 2400 ttcttctaca gcaacagagt taaagaaata gtcatagtca ttcttccacg atctttgtag 2460 tctagcttga atttcaaact gtgtccttcc ttactccaga gagggagcaa gaaaaaaaac 2520 ctggatgctt tgaagggatc tgcaactatt taaaagggga ttaggattct gtttcagctg 2580 catgtggaac taggtaagct tcagtggcct cagaactcca ggcccc 2626 <210> 217 <211> 2229 <212> DNA <213> Homo sapiens <400> 217 ccctcccggc gcagtcaccg gcgcggtcta tggctgcgac ttctctaatg tctgctttgg 60 ctgcccggct gctgcagccc gcgcacagct gctcccttcg ccttcgccct ttccacctcg 120 cggcagttcg aaatgaagct gttgtcattt ctggaaggaa actggcccag cagatcaagc 180 aggaagtgcg gcaggaggta gaagagtggg tggcctcagg caacaaacgg ccacacctga 240 gtgtgatcct ggttggcgag aatcctgcaa gtcactccta tgtcctcaac aaaaccaggg 300 cagctgcagt tgtgggaatc aacagtgaga caattatgaa accagcttca atttcagagg 360 aagaattgtt gaatttaatc aataaactga ataatgatga taatgtagat ggcctccttg 420 ttcagttgcc tcttccagag catattgatg agagaaggat ctgcaatgct gtttctccag 480 acaaggatgt tgatggcttt catgtaatta atgtaggacg aatgtgtttg gatcagtatt 540 ccatgttacc ggctactcca tggggtgtgt gggaaataat caagcgaact ggcattccaa 600 ccctagggaa gaatgtggtt gtggctggaa ggtcaaaaaa cgttggaatg cccattgcaa 660 tgttactgca cacagatggg gcgcatgaac gtcccggagg tgatgccact gttacaatat 720 ctcatcgata tactcccaaa gagcagttga agaaacatac aattcttgca gatattgtaa 780 tatctgctgc aggtattcca aatctgatca cagcagatat gatcaaggaa ggagcagcag 840 tcattgatgt gggaataaat agagttcacg atcctgtaac tgccaaaccc aagttggttg 900 gagatgtgga ttttgaagga gtcagacaaa aagctgggta tatcactcca gttcctggag 960 gtgttggccc catgacagtg gcaatgctaa tgaagaatac cattattgct gcaaaaaagg 1020 tgctgaggct tgaagagcga gaagtgctga agtctaaaga gcttggggta gccactaatt 1080 aactactgtg tcttctgtgt cacaaacagc actccaggcc agctcaagaa gcaaagcagg 1140 ccaatagaaa tgcaatattt ttaatttatt ctactgaaat ggtttaaaat gatgccttgt 1200 atttattgaa agcttaaatg ggtgggtgtt tctgcacata cctctgcagt acctcaccag 1260 ggagcattcc agtatcatgc agggtcctgt gatctagcca ggagcagcca ttaacctagt 1320 gattaatatg ggagacatta ccatatggag gatggatgct tcactttgtc aagcacctca 1380 gttacacatt cgccttttct aggattgcat ttcccaagtg ctattgcaat aacagttgat 1440 actcatttta ggtaccaaac cttttgagtt caactgatca aaccaaagga aaagtgttgc 1500 tagagaaaat tagggaaaag gtgaaaaaga aaaaatggta gtaattgagc agaaaaaaat 1560 taatttatat atgtattgat tggcaaccag atttatctaa gtagaactga attggctagg 1620 aaaaaagaaa aactgcatgt taatcatttt cctaagctgt ccttttgagg cttagtcagt 1680 ttattgggaa aatgtttagg attattcctt gctattagta ctcattttat gtatgttacc 1740 cttcagtaag ttctccccat tttagttttc taggactgaa aggattcttt tctacattat 1800 acatgtgtgt tgtcatattt ggcttttgct atatacttta acttcattgt taaatttttg 1860 tattgtatag tttctttggt gtatcttaaa acctattttt gaaaaacaaa cttggcttga 1920 taatcatttg ggcagcttgg gtaagtacgc aacttacttt tccaccaaag aactgtcagc 1980 agctgcctgc ttttctgtga tgtatgtatc ctgttgactt ttccagaaat tttttaagag 2040 tttgagttac tattgaattt aatcagactt tctgattaaa gggttttctt tcttttttaa 2100 taaaacacat ctgtctggtg tggtatgaat ttctgaaatt ctggcttcct atgactccta 2160 gttgtgacct aaccagtttt tttctcattt aatcaatgta gctatccata tcagtaacac 2220 ttacttcta 2229 <210> 218 <211> 1233 <212> DNA <213> Homo sapiens <400> 218 aagcaagaag tttctctcta atctgtgatt gctggtcttg tcaggctcta tcaagtgaaa 60 aaacagtttt ggcattcatt aaaacagtgc gaatcctgaa atgacaattg gagctggatg 120 gtatttggtg catgaaatct tcgttgtgtt caccaggata actgagaagg ctggggaggc 180 gtgaaggggg aacccacacg ttcaaaggac tgagtgtttc atccccaagt ccctcttgga 240 taaagaaagg aaactgttct tacgaattgg gaaagtgggg cagaggatgg nnnnnnnnnn 300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnag ggggaatgtt ctataaccag ctctgtaaag 360 gaaaagcact gatgtgtggt agtcaccaat ttctgtggtg taaatactcc caccatggtt 420 gatttcaagc caccagtggt ttaataacca gctcataaat ctcctaaata ttttacagtt 480 gactctcatg agctgattgg agtcagctgg aacataccac tgcctctaga ctaaggccag 540 cagatttagc aaatacagac tgccccagtt cattgaattt tagataaatg aaataaatct 600 ataaggttaa gtatgtcccc agaactgcat ggaacatgct taatctaaac aatgatttgt 660 tgttcacctg aaattcaaat ttagctgggt gtcctgtatt tcatctggca accctacttc 720 agacccaggt gtaaggtaca tggatgtgct ttggtcaagg aataggccaa ggcagagatc 780 catgcctgca tgactcagtg ggtttggtgc acaggcacac acctccactt gttatataac 840 ctgtttgtgt aagttcatac ttggtctgag ccactgttgt ctgtaaaagg taattgtcct 900 gctaatgctg tacaggggct cttggggttc ggctcagctc aacatggctt gacatggtgg 960 gcacactggc gcccagtaag agagagagag agccaaagct gtccgttttg cagatggaca 1020 ggaaggagcc aggacacagc tcagcttgct cacgcccaga gagagaaaaa gttaagctgc 1080 tgaccctgaa ggcaagggag agcaggctgc acagctgtgt gtggaagcca cgggctcaag 1140 cagccaaggc agggcggaca gtgtgagaga gctagtgtaa gctgttgatg agagctgttg 1200 ctgaataaaa ccatattcac ctgccaaaaa ctt 1233 <210> 219 <211> 2762 <212> DNA <213> Homo sapiens <400> 219 ggccgccgcg cgcccacgcg cctcgcttgc tgcgcgctgc cggcgctcct tcctcctcgg 60 ctcgcgtctc actcagtgta ccttctagtc ccgccatggc cgctctcacc cgggaccccc 120 agttccagaa gctgcagcaa tggtaccgcg agcaccgctc cgagctgaac ctgcgccgcc 180 tcttcgatgc caacaaggac cgcttcaacc acttcagctt gaccctcaac accaaccatg 240 ggcatatcct ggtggattac tccaagaacc tggtgacgga ggacgtgatg cggatgctgg 300 tggacttggc caagtccagg ggcgtggagg ccgcccggga gcggatgttc aatggtgaga 360 agatcaacta caccgagggt cgagccgtgc tgcacgtggc tctgcggaac cggtcaaaca 420 cacccatcct ggtagacggc aaggatgtga tgccagaggt caacaaggtt ctggacaaga 480 tgaagtcttt ctgccagcgt gtccggagcg gtgactggaa ggggtacaca ggcaagacca 540 tcacggacgt catcaacatt ggcattggcg gctccgacct gggacccctc atggtgactg 600 aagcccttaa gccatactct tcaggaggtc cccgcgtctg gtatgtctcc aacattgatg 660 gaactcacat tgccaaaacc ctggcccagc tgaaccccga gtcctccctg ttcatcattg 720 cctccaagac ctttactacc caggagacca tcacgaatgc agagacggcg aaggagtggt 780 ttctccaggc ggccaaggat ccttctgcag tggcgaagca ctttgttgcc ctgtctacta 840 acacaaccaa agtgaaggag tttggaattg accctcaaaa catgttcgag ttctgggatt 900 gggtgggagg acgctactcg ctgtggtcgg ccatcggact ctccattgcc ctgcacgtgg 960 gttttgacaa cttcgagcag ctgctctcgg gggctcactg gatggaccag cacttccgca 1020 cgacgcccct ggagaagaac gcccccgtct tgctggccct gctgggtatc tggtacatca 1080 actgctttgg gtgtgagaca cacgccatgc tgccctatga ccagtacctg caccgctttg 1140 ctgcgtactt ccagcagggc gacatggagt ccaatgggaa atacatcacc aaatctggaa 1200 cccgtgtgga ccaccagaca ggccccattg tgtgggggga gccagggacc aatggccagc 1260 atgcttttta ccagctcatc ccggtccaga cccagcaccc catacggaag ggtctgcatc 1320 acaagatcct cctggccaac ttcttggccc agacagaggc cctgatgagg ggaaaatcga 1380 cggaggaggc ccgaaaggag ctccaggctg cgggcaagag tccagaggac cttgagaggc 1440 tgctgccaca taaggtcttt gaaggaaatc gcccaaccaa ctctattgtg ttcaccaagc 1500 tcacaccatt catgcttgga gccttggtcg ccatgtatga gcacaagatc ttcgttcagg 1560 gcatcatctg ggacatcaac agctttgacc agtggggagt ggagctggga aagcagctgg 1620 ctaagaaaat agagcctgag cttgatggca gtgctcaagt gacctctcac gacgcttcta 1680 ccaatgggct catcaacttc atcaagcagc agcgcgaggc cagagtccaa taaactcgtg 1740 ctcatctgca gcctcctctg tgactcccct ttctcttctc gtccctcctc cccggagccg 1800 gcactgcatg ttcctggaca ccacccagag caccctctgg ttgtgggctt ggaccacgag 1860 cccttagcag ggaaggctgg tctcccccag cctaaccccc agcccctcca tgtctatgct 1920 ccctctgtgt tagaattggc tgaagtgttt ttgtgcagct gacttttctg acccatgttc 1980 acgttgttca catcccatgt agaaaaataa agatgccacg gaggaggttg taggctcagc 2040 ctctgatttt ttttttcctg tgatggtgct ttatgtagca gagggcagga gcgctcagca 2100 ggacgcaggc tgtgcctctg cggacactta acactaagtg gtgagcgggt ctagagtgga 2160 gcaaggtgcc ctgagaagac aatagtgggg tgggggcaca atcagtcagg acggcaactt 2220 ggcctgtgtc accaaatccc aagactgttt tccactcctc acctctgtga ctggagaaat 2280 tggatactct gttcactcga tggttctaaa aactgcattg agattatgtt tgtttcgggt 2340 gaattcctgg acaagaccga ggatgactgc catctcctgg caagacgctc aggtagttct 2400 tttgctttaa aaggcagagc gagactccat cccccaccgc cccgcaaaaa aaaaggaaaa 2460 gagaaagatt tattttttga acctctggtt tgtgccaggt accatattag gccctaaaga 2520 taccagaggg aacaaaacag acctcatgaa actgatgttt tagtgggggc agacaaatag 2580 taaataagta aacatccatg agatccatta tgatgagtgt tatgagaaga ataaagactg 2640 gaaggaaaat gggagaatgt tggggagggt tagtttggga taaggaaggt gaggacaggg 2700 caggccccaa ctgacaagga aacgtttgaa taaagagcct aaggaggcaa ggcggggagc 2760 cg 2762 <210> 220 <211> 3106 <212> DNA <213> Homo sapiens <400> 220 gccattttcc cagagcgaga ggcagtgaca ctgagcgggc gcagggggcc gagtcggaga 60 ccgtgccgga gttcgggagc ggcaacagag tgggcataga cactccgagc agcctcgccg 120 tcgtctctgc gttcctgttg actgcctggc tgccccctcc cctactcctc ggttcctggt 180 gaagaggctg cgcgctgctg tttggggagg gggtgtgtgg agccgggtcc tgtgtccgca 240 gtggctgctg tcggggggtc gcctgttcgc ggaggtgcgg agagactcct tgggggtcga 300 gcacataacg gggttcgggt gtctcgtgtg tgaacatcac agggtttgtg gatgcactta 360 gatgtttgca atgagcactg tggctggcat gccccagtgt tttggatacc aatgcatagg 420 actccatagt aatcgaattt accagaggcg aacgtcatga gcatagtgat cccattgggg 480 gttgatacag cagagacgtc atacttggaa atggctgcag gttcagaacc agaatccgta 540 gaagctagcc ctgtggtagt tgagaaatcc aacagttatc cccaccagtt atataccagc 600 agctcacatc attcacacag ttacattggt ttgccctatg cggaccataa ttatggtgct 660 cgtcctcctc cgacacctcc ggcttcccct cctccatcag tccttattag caaaaatgaa 720 gtaggcatat ttaccactcc taattttgat gaaacttcca gtgctactac aatcagcaca 780 tctgaggatg gaagttatgg tactgatgta accaggtgca tatgtggttt tacacatgat 840 gatggataca tgatctgttg tgacaaatgc agcgtttggc aacatattga ctgcatgggg 900 attgataggc agcatattcc tgatacatat ctatgtgaac gttgtcagcc taggaatttg 960 gataaagaga gggcagtgct actacaacgc cggaaaaggg aaaatatgtc agatggtgat 1020 accagtgcaa ctgagagtgg tgatgaggtt cctgtggaat tatatactgc atttcagcat 1080 actccaacat caattacttt aactgcttca agagtttcca aagttaatga taaaagaagg 1140 aaaaaaagcg gggagaaaga acaacacatt tcaaaatgta aaaaggcatt tcgtgaagga 1200 tctaggaagt catcaagagt taagggttca gctccagaga ttgatccttc atctgatggt 1260 tcaaattttg gatgggagac aaagatcaaa gcatggatgg atcgatatga agaagcaaat 1320 aacaaccagt acagtgaggg tgttcagagg gaggcacaaa gaatagctct gagattaggc 1380 aatggaaatg acaaaaaaga gatgaataaa tccgatttga ataccaacaa tttgctcttc 1440 aaacctcctg tagagagcca tatacaaaag aataagaaaa ttcttaaatc tgcaaaagat 1500 ttgcctcctg atgcacttat cattgaatac agagggaagt ttatgctgag agaacagttt 1560 gaagcaaatg ggtatttctt taaaagacca tacccttttg tgttattcta ctctaaattt 1620 catgggctag aaatgtgtgt tgatgcaagg acttttggga atgaggctcg attcatcagg 1680 cggtcttgta cacccaatgc agaggtgagg catgaaattc aagatggaac catacatctt 1740 tatatttatt ctatacacag tattccaaag ggaactgaaa ttactattgc ctttgatttt 1800 gactatggaa attgtaagta caaggtggac tgtgcatgcc tcaaagaaaa cccagagtgc 1860 cctgttctaa aacgtagttc tgaatccatg gaaaatatca atagtggtta tgagaccaga 1920 cggaaaaaag gaaaaaaaga caaagatatt tcaaaagaaa aagatacaca aaatcagaat 1980 attactttgg attgtgaagg aacgaccaac aaaatgaaga gcccagaaac taaacaaaga 2040 aagctttctc cactgagact atcagtatca aataatcagg aaccagattt tattgatgat 2100 atagaagaaa aaactcctat tagtaatgaa gtagaaatgg aatcagagga gcagattgca 2160 gaaaggaaaa ggaagatgac aagagaagaa agaaaaatgg aagcaatttt gcaagctttt 2220 gccagacttg aaaagagaga gaaaagaaga gaacaagctt tggaaaggat cagcacagcc 2280 aaaactgaag ttaaaactga atgtaaagat acacagattg tcagtgatgc tgaagttatt 2340 caggaacaag caaaagaaga aaatgctagc aagccaaccc ctgccaaagt aaatagaact 2400 aaacagagaa aaagtttttc tcggagtagg actcacattg gacagcagcg tcggagacac 2460 agaactgtca gcatgtgttc agatatccag ccatcttctc ctgatataga agttacttca 2520 caacaaaatg atattgaaaa tactgtactt acaatagaac cagaaactga aactgcacta 2580 gcagaaataa ttactgaaac tgaagttcca gcacttaata aatgtcctac caagtacccc 2640 aaaacaaaga aggtatgatt ctaatgaatg taagaactgt ttttctaaca gtttcttata 2700 ttaattatat tgttgtttta aaaattggat ttttaagacc tcataataat aagaggcagt 2760 ttttatactt gcagatttta aaactaagaa tgagaattcc aaaactgtaa aattaatata 2820 aatgtttgca ttactgtgaa gataaagtta cattcagttt atcaggactt ttatggtatt 2880 gcaattcatg atttctttaa ataagtttgt ctactttatg tacaaaatat atacttctct 2940 gaaactggtt ttagatgtgt tatcctttat atttttataa atttcattgt ataggtagat 3000 tataagaatt aaatgtgaag aaattgattt ccacagaatg tactatgaaa atttgtaaga 3060 aagagtagtt ttaggtgtaa ttattaataa aaatctctga aacact 3106 <210> 221 <211> 2826 <212> DNA <213> Homo sapiens <400> 221 gctgcctccc taccactgtt ctctgagaag agcaagacca ccaaggacag tccacaggca 60 gctcgggatg gaaagagagg ggtgggcagt gctggatggc cagacagggt caccttccgg 120 ggccaataca caggtaggtc aggagggagg gccaggatgg gtgcagctcc tggtgtcagc 180 gggggctcct ctgttatgag aagccctttc catataccca gtgggccatt caaatatcat 240 tttctatcag ttctgtgata tgaaaaccag cagggagcat tgcctccatg aatctcggtg 300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngcaaac actttctgat gcttcccctt 360 tgccagggcc catgcttggt tctgggaagt ctgttcagct ggtcaatcct aaagaagttc 420 tgatcacctg tgcttttccg gctcggagca tacagggtgg acactgaatt ggatgtccca 480 tttgcacctg gcttccttca ggttctctga ttcccagaag agccacagag cccagcacac 540 cccggagccc aagcacagag gtacctctcc agcccaagtg ggcctctccg gcagagggca 600 cccaacttca gcctggagcg tacactgcca gccgagatgg cggttcctgg ctcagagttt 660 gaggggcaca aacggatttc tgaacagccc cttcccaaca agacaatcag cccaccccca 720 gcccccgccc ctgccgctgc gcctctaccc tgtggaccaa cagagaccat ccccagcttc 780 ctgctcacca ggcagggcga gaccaggcca tctgtgagct gcaagaagag gtgtcccggc 840 ttcgtctgcg gctggaagac agcctgcacc agccactcca ggcagcccga cacgcccagc 900 atctgccttt gaccgccccg cccggacccg cggccggcca gcagactccc cagccacctg 960 gggctcccat tatggcagta aatccacaga gagattgcct ggtgagccta gaggtgaaga 1020 gcagattgtc cctccaggaa ggcagcgagc caggtcttcc tcagtgcctc gggaggtgct 1080 ccgactgtcc ctgagttcag aatctgagct gccctcccta ccactgttct ctgagaagag 1140 caagaccacc aaggacagtc cacaggcagc tcgggatgga aagagagggg tgggcagtgc 1200 tggatggcca gacagggtca ccttccgggg ccaatacaca ggccacgaat accatgttct 1260 gtcccctaag gcggtcccaa aaggcaatgg cacagtctcc tgtccccact gccggcccat 1320 taggacccag gatgcgggtg gtgctgtcac aggggaccca ctgggaccgc ctcccgctga 1380 tacccttcag tgtcccctgt gtggtcaagt tgggtctccc ccagaggcag atggtccagg 1440 ctcagccacc tctggggcag agaaggccac cacgaggaga aaagcacctt caactcccag 1500 ccccaagcag aggagcaagc aggcggggtc gtcgccacgc ccaccccccg gactgtggta 1560 tctggcaaca gcgcccccag caccagcccc tccagccttt gcctacatct cctcggttcc 1620 catcatgcct tatccacctg ccgctgtgta ctatgcgcct gcaggaccta cctcagccca 1680 accagctgcc aagtggccgc ccacagcctc tcccccacca gcccggagac accggcactc 1740 catccagctc gacctgggcg acctagagga gctcaacaag gccctgagcc gggccgtgca 1800 ggctgccgag agcgtccgct ctaccaccag gcagatgaga agctcgctgt cagccgacct 1860 gcgccaggct cacagcctgc ggggctcctg cctcttctga cttcactggg ggcccagagg 1920 cagatgggtg ggtgggtggg caggtggcct gccaggccag gagtgggctg gagctgctga 1980 ggcccagaag gcccgcatag ttcctcacca ggagggtctc cctccagcac aggtcccgcc 2040 tgctcagtcc ctgtgctttc caagtggagg gggtgtcagc tcggtcacca agagaagtga 2100 cttcccagga gcaccagtcc cctcacagag gtgctgtgag cgaggcctcc ttcggtccag 2160 gcagaacctc aggcagtctc tcctggtcct gcatgtgtgc aactccagct aataataggt 2220 attttatata cagatggaca gatatttttt taaactgggg agttttcctg atcttgggtc 2280 ctctttaggg ggccagacaa gaaaggccta cggtttctgg agcaaacctg tcccccacct 2340 gtgaccagtc actctggggc aagcatcact gggaagggca tagccggaga cctttctcct 2400 agtgactggt agtcagtggg gcattttagg atgtcagggc cccagggtga catgtgtcca 2460 gcttttctat ggcagcagag gcctttccct cagacaagct acaaagtgcc caggatgcca 2520 tccaccatgg tccccttcag tacctcacgc atggtcccca gcttctccta ggatcccagt 2580 ggcatttatc agtggccagc tacctgccag gcccgggctg gggcacggtc tgcggccatg 2640 aggccaggcc gcctcccgca cccctacccc gtggcagcag catacctctg catttctgga 2700 atgtgtgtgc atcaatgatg tttgtatatt tgaggcattt aaaaatctat tttcgttacg 2760 agggcaaatg aagaatgaat attgatctta aaaaaagaaa agaagacaaa aaaaataccc 2820 aaagcc 2826 <210> 222 <211> 1641 <212> DNA <213> Homo sapiens <400> 222 ggatctccgg gcttcatttt ctgccctcca ccatcatggg gtcaaccgcc atcctcgccc 60 tcctcctggc tgttctccaa ggagtctctg ccgaggtgca gctggtgcag tctggagcag 120 aggtgaaaaa ggccggggag cctctgaaga tctcctgtga agtttccgga tacaccttca 180 ccgactactg gctcgcctgg gtgcgccgga tgcccgggaa aggcctggag tgcataggga 240 tcatctatcc tcgtgactct gataccaaat acagtccgtc ctttcaaggc caggtcacca 300 tttcagtcga caagtccatc aataccgcct atctgcagtg gagcagcctg aaggtctcgg 360 acacggccgt gtattactgt gcgagacatt tggatgtcag ctcgtcgtcc tggtacttcg 420 atctctgggg ccgtggcacc ctggtcatcg tctcctcagc atccccgacc agccccaagg 480 tcttcccgct gagcctctgc agcacccagc cagatgggaa cgtggtcatc gcctgcctgg 540 tccagggctt cttcccccag gagccactca gtgtgacctg gagcgaaagc ggacagggcg 600 tgaccgccag aaacttccca cccagccagg atgcctccgg ggacctgtac accacgagca 660 gccagctgac cctgccggcc acacagtgcc tagccggcaa gtccgtgaca tgccacgtga 720 agcactacac gaatcccagc caggatgtga ctgtgccctg cccagttccc tcaactccac 780 ctaccccagt tccctcaact ccacctaccc catctccctc aactccacct accccatctc 840 cctcatgctg ccacccccga ctgtcactgc accgaccggc cctcgaggac ctgctcttag 900 gttcagaagc gaacctcacg tgcacactga ccggcctgag agatgcctca ggtgtcacct 960 tcacctggac gccctcaagt gggaagagcg ctgttcaagg accacctgag cgtgacctct 1020 gtggctgcta cagcgtgtcc agtgtcctgc cgggctgtgc cgagccatgg aaccatggga 1080 agaccttcac ttgcactgct gcctaccccg agtccaagac cccgctaacc gccaccctct 1140 caaaatccgg aaacacattc cggcccgagg tccacctgct gccgccgccg tcggaggagc 1200 tggccctgaa cgagctggtg acgctgacgt gcctggcacg cggcttcagc cccaaggacg 1260 tgctggttcg ctggctgcag gggtcacagg agctgccccg cgagaagtac ctgacttggg 1320 catcccggca ggagcccagc cagggcacca ccaccttcgc tgtgaccagc atactgcgcg 1380 tggcagccga ggactggaag aagggggaca ccttctcctg catggtgggc cacgaggccc 1440 tgccgctggc cttcacacag aagaccatcg accgcttggc gggtaaaccc acccatgtca 1500 atgtgtctgt tgtcatggcg gaggtggacg gcacctgcta ctgagccgcc cgcctgtccc 1560 cacccctgaa taaactccat gctcccccaa gcaaaaaaaa gggggatcca ctagttctat 1620 aagcgccgac gcgcgtgctc c 1641 <210> 223 <211> 6887 <212> DNA <213> Homo sapiens <400> 223 cggaggagcg cgcggttgcc gggcgggacg ggaaccgggt ctgcgcgcga gccgggcggt 60 gggcgcggac agggccgagg gcgcccggga gccgtgtcag gcggcggcga ggagcgggcg 120 cgccgggcgc ggggagccgt cggcggccgc tcgctgcggg gacaccccgg tgaatgagct 180 ctcgccgcca ggcgcacggc gtaggggagc ctcgcagtgc ggcggcgtgc ggcggcggct 240 cggggggcga ggcgggccgc ctgttcccgg ggaaggaggc gcgggcgtct gagcgaggcc 300 gggcgcggcg gccttctctc acgcgccccc cgagccagcg cccgcctccc gcgcccgcct 360 ctcttctccc gtcggcccag actatccgct cccaccgcgc cccccggccc acctggtggc 420 cccggccctg gccgccgccc ccgcggcggt tcccggagct cgtcccggac gcgcgcccgg 480 gcggcggggg ctcggcggcc accgctgcct cgggggagcg agggcgggag ggtgtgtgtg 540 cgcgctgtga gcagggggtg ccggcggggc tgcagcggag gcactttgga agaatgactc 600 tggagtccat catggcgtgc tgcctgagcg aggaggccaa ggaagcccgg cggatcaacg 660 acgagatcga gcggcagctc cgcagggaca agcgggacgc ccgccgggag ctcaagctgc 720 tgctgctcgg gacaggagag agtggcaaga gtacgtttat caagcagatg agaatcatcc 780 atgggtcagg atactctgat gaagataaaa ggggcttcac caagctggtg tatcagaaca 840 tcttcacggc catgcaggcc atgatcagag ccatggacac actcaagatc ccatacaagt 900 atgagcacaa taaggctcat gcacaattag ttcgagaagt tgatgtggag aaggtgtctg 960 cttttgagaa tccatatgta gatgcaataa agagtttatg gaatgatcct ggaatccagg 1020 aatgctatga tagacgacga gaatatcaat tatctgactc taccaaatac tatcttaatg 1080 acttggaccg cgtagctgac cctgcctacc tgcctacgca acaagatgtg cttagagttc 1140 gagtccccac cacagggatc atcgaatacc cctttgactt acaaagtgtc attttcagaa 1200 tggtcgatgt agggggccaa aggtcagaga gaagaaaatg gatacactgc tttgaaaatg 1260 tcacctctat catgtttcta gtagcgctta gtgaatatga tcaagttctc gtggagtcag 1320 acaatgagaa ccgaatggag gaaagcaagg ctctctttag aacaattatc acatacccct 1380 ggttccagaa ctcctcggtt attctgttct taaacaagaa agatcttcta gaggagaaaa 1440 tcatgtattc ccatctagtc gactacttcc cagaatatga tggaccccag agagatgccc 1500 aggcagcccg agaattcatt ctgaagatgt tcgtggacct gaacccagac agtgacaaaa 1560 ttatctactc ccacttcacg tgcgccacag acaccgagaa tatccgcttt gtctttgctg 1620 ccgtcaagga caccatcctc cagttgaacc tgaaggagta caatctggtc taattgtgcc 1680 tcctagacac ccgccctgcc cttccctggt gggctattga agatacacaa gagggactgt 1740 atttctgtgg aaaacaattt gcataatact aatttattgc cgtcctggac tctgtgtgag 1800 cgtgtccaca gagtttgtag taaatattat gattttattt aaactattca gaggaaaaac 1860 agaggatgct gaagtacagt cccagcacat ttcctctcta tctttttttt aggcaaaacc 1920 ttgtgactca gtgtatttta aattctcagt catgcactca caaagataag acttgtttct 1980 ttctgtctct ctctcttttt cttttctatg gagcaaaaca aagctgattt cccttttttc 2040 ttcccccgct aattcatacc tccctcctga tgtttttccc aggttacaat ggcctttatc 2100 ctagttccat tcttggtcaa gtttttctct caaatgatac agtcaggaca caccgttcga 2160 tttaagccat catcagctta atttaagttt gtagtttttg ctgaaggatt atatgtatta 2220 atacttacgg ttttaaatgt gttgctttgg atacacacat agtttctttt ttaatagaat 2280 atactgtctt gtctcacttt ggactgggac agtggatgcc catctaaaag ttaagtgtca 2340 tttcttttag atgtttacct tcagccatag cttgattgct cagagaaata tgcagaaggc 2400 aggatcaaag acacacagga gtcctttctt ttgaaatgcc acgtgccatt gtctttcctc 2460 ccttctttgc ttctttttct taccctctct ttcaattgca gatgccaaaa aagatgccaa 2520 cagacactac attaccctaa tggctgctac ccagaacctt tttataggtt gttcttaatt 2580 tttttgttgt tgttgttcaa gcttttcctt tctttttttt cttagtgttt gggccacgat 2640 tttaaaatga cttttattat gggtatgtgt tgccaaagct ggctttttgt caaataaaat 2700 gaatacgaac ttaaaaaata aaagctggta tcttaaaatg taagagagta agactgtgaa 2760 gcctaaaatg actggctgag aatgaaccag aaatgccatt tgccaaacag ttgtaactag 2820 aaatttgatt ctcacagtcc attcttttct ttgtccttaa gatgacattg ttagtgttca 2880 cgtcccatgt tcagtgtcca aaccggcaat gtaaaaagta tcctgtgtgg cttaacagga 2940 aatctgttta tgtctcttta tttgaaacca gttttactct cagtggttct ttaagttcaa 3000 tgaagtctgc caggaacatt ggttggtagt attattccga cacctttaat ttccaaaatc 3060 tgaagttcct gctagtttac caccttcatg atcttcttga actggtaact gattaggttg 3120 aacttatgga agatttgtgg acttaactca aaagtaacct ctcagtgttc tatagaacat 3180 gtatttgtgt aactgaacct accaggagaa atgtttggaa ttctatatgt gcaatttttc 3240 aacaaatgca aaaaaaatac agcacatgta ttgacaagct tctgtcaagc agcttgagtt 3300 gaaatttgat ttaagaaaat aaatcatgat tgttcaaagc tgctgggacg ttagaattag 3360 gccatgatac tggtctcatt ttaactacag tggtatttgg cactagtgta aacttccata 3420 taaatcactc ttttggaaca acaaaggggg agggagaaaa atcacggcct gttaaatgag 3480 taccaaagcc gcccaacagt aatgagatgt tctcatcctt gattctccca gcctcaaaca 3540 acacagctta cttttttttt cccttgctca gaaagtacct gtaatttaac aaacagactg 3600 cctgtaggta tagtgcaatt acaaatgctc taatcattgt acatacatct ctcttgatat 3660 tgcagcatcc atactggctt tgtaatcatt aattttttgg cagattgaat gtgctgtatt 3720 gatatgtatc tatgtaattg tattgtatgt ctatagctaa ttcacgtttt gaataatgtt 3780 attttattta cttttttaag agaggagaat gtaaatttgt cagtttattt ctgactaggg 3840 atattttctt tccatttaga aaagaaggaa aaaaaaaaac cttactgtca tacagagcgg 3900 tactagcgtc gtgctgtata aaatcatttg cacattcctg agtagaggta tactgattat 3960 aagacccaaa ggtaatttca tagcaaaata cataaaatca gtcggagctt ttatacaaac 4020 atggaaacca actttgtaga acttttgcca tttgatctag gattggaata tgagctttta 4080 tacaattcat attcttattt ggcaaatgca cagtttagta ttacctctct gatggccttt 4140 actagaaagg cagttttaga agctattgtg atccactaag gaaatgtttt aacagctaga 4200 gaccactgct tgcctgaaag ggcgttctta aatttggtgc agcnnnnnnn nnnnnnnnnn 4260 nnnnnnnnnn nnnnnnnnca acatttgaag gcctacagtg tgtatagaga aaacctcatc 4320 acaagatcat aagtgttaca gttttaggga atcaagatat tctatttaat agagctatag 4380 taaatgtagt caattaaacc tgatctcaaa gcttgaagaa gctgagcaaa acagggaaag 4440 attgttatat ttgtctttat gaaattggga tggaatttgc tatgcagaat tgaggtttgt 4500 ggctttgctg ttcctgtagg gtgcatgaca agatcccttc tcttgagaaa ggaaaaaatt 4560 gatcacccta gcagcagtga tgcatagaaa cctaatttta gccacaccag tcaatcgaag 4620 ctaaaggatt ttcttttttg tttcttcggg gttttattga aggggctagg ggcgggacgg 4680 gattcttttc agttttgtat aaaaacaaag tttactcatg ctttatatta tattgtgatt 4740 gcaagcgtta taagcgtgtg ccactggcct cctattgttg atgcttaggt aatggaggcc 4800 tgtggtgagt tttatggtga cttgggcatg tcttattcaa aaacaaaaac ataaaacaca 4860 gaaacctttc ttcagcatac caaggcaagc agccatttca tgactcactt aacacattgc 4920 agtgtaccag tttacagatg atttttccct ttttgcgtga catggcagtt ctaaccccca 4980 gagaattcct tatttgtaaa ttggaagttt ctactatgcc ttacagagct taaattcaga 5040 agtttgtgcc tcatatctga aacaaaggga aataacacac ccattcaaaa gtaaataaat 5100 ctcctagaag tttttgtttt taacatttcc atataaagag ctctgttgaa tgtcatgaat 5160 agactggaaa aaaaaatttt aagaacctgc atatgttgtt tactagcaga tgacaactac 5220 aaaaggaatc tgaagaacac gtaaaacttg tatttttttt tttttggtag attaactagc 5280 aggcctattt taaaaaggta attcagctaa agggcaattt acttttttgt acttcagact 5340 atcttgattg tcaaagtgta cgaactgtaa ttttaaaatt tatactgcca catgattgta 5400 aattttagtt gtcttaagtt aggaattggt gaaaagctat ttatgctgga tttgggtcaa 5460 aatgacttat ttgcaaaaaa ataaataatg ggaagaaagg gctgtataat gaaatactgc 5520 aagactcaca tattggttgg aaatttccct caaatcacct accgattacc cttgatttcc 5580 ctttgttttc agtttctcaa aacgaatgaa atgaaatata gcagaatgtt aacccatata 5640 aaaataaagt gtacccaaat attgtaatgt atattgctgc tcttcttcaa attaaataag 5700 ggtttaaaac cacttaattg gtaatcaaca tctcaattga tacaaataag gtgtgcttgg 5760 tatacattaa tattttcttc caaagatata tctttggtta gaaacacaaa aaaataaaac 5820 tagtaatatt gtatgtttat ctatctctac atatttccag catatgtagc gttaatagat 5880 ctgtcctggt aactgtgtct ttgggatttc attttggttc catcaaatta ggaaaagaaa 5940 tggcttagtt gtatatgatt agctagagat ttttggagcc agacacctgc tgtttagtag 6000 ataacttagt acagacccta aacttgtcat ttgtttttct cacagaatag ccatttcctg 6060 ctgtcttccc aatgatcact gccctttcaa taacactctt gcctctagaa tcatatgttc 6120 aaagtatgaa tacacaccta gcacatagta ggtgctcaaa tattaatttc ctccttgcct 6180 tccttatcta ccctgtgtcc tccatttccc cgtatgattc caacccaata tagcaaatga 6240 catttacatg ttatgaaaac atctattggg taaaatcaga tcttggataa agaaattctg 6300 acttttatat aagcttttgg tagacagaaa aaacagaaag gtattcgttg gtagaacatt 6360 tttaagttca ggaaagaaag ctggaataat actacgtaac tttgtccagg ttactttgac 6420 tgaaacacgt ttttggtgga tttcttttcc tcaaagaact ctctaaatgc aactccttgc 6480 tggattcctc acccatcatc ctgttggaaa cccttactag acctatgtat ttagggagtt 6540 ttgtcagaaa acatttttaa cttgcagtat ttaaaagaat atttactgtt cctaaaatgt 6600 cattcaaatg catgtactgt ctattgtttg gggatgggaa ctagttttgc aaaaaacacc 6660 taatgttgta taataatgcc ccaatgatct tgctggttaa aaatacagta tttttggcca 6720 taattttgta ctatagtatt cttcattgtt gagttttgct tccattaaag ttgcccgagc 6780 ccctctcaga atgttttgta ttagtaggag tactgaaata catctttcct tccttaacac 6840 accttgtgca tattgcattt tccaaaataa acaagtttaa tggtttc 6887 <210> 224 <211> 8951 <212> DNA <213> Homo sapiens <400> 224 accgggagcg cgcgctctga tccgaggaga ccccgcgctc ccgcagccat gggcaccggg 60 ggccggcggg gggcggcggc cgcgccgctg ctggtggcgg tggccgcgct gctactgggc 120 gccgcgggcc acctgtaccc cggagaggtg tgtcccggca tggatatccg gaacaacctc 180 actaggttgc atgagctgga gaattgctct gtcatcgaag gacacttgca gatactcttg 240 atgttcaaaa cgaggcccga agatttccga gacctcagtt tccccaaact catcatgatc 300 actgattact tgctgctctt ccgggtctat gggctcgaga gcctgaagga cctgttcccc 360 aacctcacgg tcatccgggg atcacgactg ttctttaact acgcgctggt catcttcgag 420 atggttcacc tcaaggaact cggcctctac aacctgatga acatcacccg gggttctgtc 480 cgcatcgaga agaacaatga gctctgttac ttggccacta tcgactggtc ccgtatcctg 540 gattccgtgg aggataatta catcgtgttg aacaaagatg acaacgagga gtgtggagac 600 atctgtccgg gtaccgcgaa gggcaagacc aactgccccg ccaccgtcat caacgggcag 660 tttgtcgaac gatgttggac tcatagtcac tgccagaaag tttgcccgac catctgtaag 720 tcacacggct gcaccgccga aggcctctgt tgccacagcg agtgcctggg caactgttct 780 cagcccgacg accccaccaa gtgcgtggcc tgccgcaact tctacctgga cggcaggtgt 840 gtggagacct gcccgccccc gtactaccac ttccaggact ggcgctgtgt gaacttcagc 900 ttctgccagg acctgcacca caaatgcaag aactcgcgga ggcagggctg ccaccagtac 960 gtcattcaca acaacaagtg catccctgag tgtccctccg ggtacacgat gaattccagc 1020 aacttgctgt gcaccccatg cctgggtccc tgtcccaagg tgtgccacct cctagaaggc 1080 gagaagacca tcgactcggt gacgtctgcc caggagctcc gaggatgcac cgtcatcaac 1140 gggagtctga tcatcaacat tcgaggaggc aacaatctgg cagctgagct agaagccaac 1200 ctcggcctca ttgaagaaat ttcagggtat ctaaaaatcc gccgatccta cgctctggtg 1260 tcactttcct tcttccggaa gttacgtctg attcgaggag agaccttgga aattgggaac 1320 tactccttct atgccttgga caaccagaac ctaaggcagc tctgggactg gagcaaacac 1380 aacctcacca tcactcaggg gaaactcttc ttccactata accccaaact ctgcttgtca 1440 gaaatccaca agatggaaga agtttcagga accaaggggc gccaggagag aaacgacatt 1500 gccctgaaga ccaatgggga ccaggcatcc tgtgaaaatg agttacttaa attttcttac 1560 attcggacat cttttgacaa gatcttgctg agatgggagc cgtactggcc ccccgacttc 1620 cgagacctct tggggttcat gctgttctac aaagaggccc cttatcagaa tgtgacggag 1680 ttcgacgggc aggatgcgtg tggttccaac agttggacgg tggtagacat tgacccaccc 1740 ctgaggtcca acgaccccaa atcacagaac cacccagggt ggctgatgcg gggtctcaag 1800 ccctggaccc agtatgccat ctttgtgaag accctggtca ccttttcgga tgaacgccgg 1860 acctatgggg ccaagagtga catcatttat gtccagacag atgccaccaa cccctctgtg 1920 cccctggatc caatctcagt gtctaactca tcatcccaga ttattctgaa gtggaaacca 1980 ccctccgacc ccaatggcaa catcacccac tacctggttt tctgggagag gcaggcggaa 2040 gacagtgagc tgttcgagct ggattattgc ctcaaagggc tgaagctgcc ctcgaggacc 2100 tggtctccac cattcgagtc tgaagattct cagaagcaca accagagtga gtatgaggat 2160 tcggccggcg aatgctgctc ctgtccaaag acagactctc agatcctgaa ggagctggag 2220 gagtcctcgt ttaggaagac gtttgaggat tacctgcaca acgtggtttt cgtccccagg 2280 ccatctcgga aacgcaggtc ccttggcgat gttgggaatg tgacggtggc cgtgcccacg 2340 gtggcagctt tccccaacac ttcctcgacc agcgtgccca cgagtccgga ggagcacagg 2400 ccttttgaga aggtggtgaa caaggagtcg ctggtcatct ccggcttgcg acacttcacg 2460 ggctatcgca tcgagctgca ggcttgcaac caggacaccc ctgaggaacg gtgcagtgtg 2520 gcagcctacg tcagtgcgag gaccatgcct gaagccaagg ctgatgacat tgttggccct 2580 gtgacgcatg aaatctttga gaacaacgtc gtccacttga tgtggcagga gccgaaggag 2640 cccaatggtc tgatcgtgct gtatgaagtg agttatcggc gatatggtga tgaggagctg 2700 catctctgcg tctcccgcaa gcacttcgct ctggaacggg gctgcaggct gcgtgggctg 2760 tcaccgggga actacagcgt gcgaatccgg gccacctccc ttgcgggcaa cggctcttgg 2820 acggaaccca cctatttcta cgtgacagac tatttagacg tcccgtcaaa tattgcaaaa 2880 attatcatcg gccccctcat ctttgtcttt ctcttcagtg ttgtgattgg aagtatttat 2940 ctattcctga gaaagaggca gccagatggg ccgctgggac cgctttacgc ttcttcaaac 3000 cctgagtatc tcagtgccag tgatgtgttt ccatgctctg tgtacgtgcc ggacgagtgg 3060 gaggtgtctc gagagaagat caccctcctt cgagagctgg ggcagggctc cttcggcatg 3120 gtgtatgagg gcaatgccag ggacatcatc aagggtgagg cagagacccg cgtggcggtg 3180 aagacggtca acgagtcagc cagtctccga gagcggattg agttcctcaa tgaggcctcg 3240 gtcatgaagg gcttcacctg ccatcacgtg gtgcgcctcc tgggagtggt gtccaagggc 3300 cagcccacgc tggtggtgat ggagctgatg gctcacggag acctgaagag ctacctccgt 3360 tctctgcggc cagaggctga gaataatcct ggccgccctc cccctaccct tcaagagatg 3420 attcagatgg cggcagagat tgctgacggg atggcctacc tgaacgccaa gaagtttgtg 3480 catcgggacc tggcagcgag aaactgcatg gtcgcccatg attttactgt caaaattgga 3540 gactttggaa tgaccagaga catctatgaa acggattact accggaaagg gggcaagggt 3600 ctgctccctg tacggtggat ggcaccggag tccctgaagg atggggtctt caccacttct 3660 tctgacatgt ggtcctttgg cgtggtcctt tgggaaatca ccagcttggc agaacagcct 3720 taccaaggcc tgtctaatga acaggtgttg aaatttgtca tggatggagg gtatctggat 3780 caacccgaca actgtccaga gagagtcact gacctcatgc gcatgtgctg gcaattcaac 3840 cccaagatga ggccaacctt cctggagatt gtcaacctgc tcaaggacga cctgcacccc 3900 agctttccag aggtgtcgtt cttccacagc gaggagaaca aggctcccga gagtgaggag 3960 ctggagatgg agtttgagga catggagaat gtgcccctgg accgttcctc gcactgtcag 4020 agggaggagg cggggggccg ggatggaggg tcctcgctgg gtttcaagcg gagctacgag 4080 gaacacatcc cttacacaca catgaacgga ggcaagaaaa acgggcggat tctgaccttg 4140 cctcggtcca atccttccta acagtgccta ccgtggcggg ggcgggcagg ggttcccatt 4200 ttcgctttcc tctggtttga aagcctctgg aaaactcagg attctcacga ctctaccatg 4260 tccagtggag ttcagagatc gttcctatac atttctgttc atcttaaggt ggactcgttt 4320 ggttaccaat ttaactagtc ctgcagagga tttaactgtg aacctggagg gcaaggggtt 4380 tccacagttg ctgctccttt ggggcaacga cggtttcaaa ccaggatttt gtgttttttc 4440 gttcccccca cccgccccca gcagatggaa agaaagcacc tgtttttaca aannnnnnnn 4500 nnnnnnnnnn ngctggtgtc tgagcttcag tataaaagac aaaacttcct gtttgtggaa 4560 caaaagttcg aaagaaaaaa caaaacaaaa acacccagcc ctgttccagg agaatttcaa 4620 gttttacagg ttgagcttca agatggtttt tttggttttt tttttttctc tcatccaggc 4680 tgaaggattt tttttttctt tacaaaatga gttcctcaaa ttgaccaata gctgctgctt 4740 tcatattttg gataagggtc tgtggtcccg gcgtgtgctc acgtgtgtat gcacgtgtgt 4800 gtgtccatta gacacggctg atgtgtgtgc aaagtatcca tgcggagttg atgctttggg 4860 aattggctca tgaaggttct tctcaagggt gcgagctcat ccccctctct ccttccttct 4920 tattgactgg gagactgtgc tctcgacaga ttcttcttgt gtcagaagtc tagcctcagg 4980 tttctaccct cccttcacat tggtggccaa gggaggagca tttcatttgg agtgattatg 5040 aatcttttca agaccaaacc aagctaggac attnnnnnnn nnnnnnnnnn nnnnnnnnnn 5100 aaacaaaatg gaaaaaggaa aaaaaaaaag aactgagatg acagagtttt gagaatatat 5160 ttgtaccata tttaattttt aaagtctctg gtattagcct cataagttat tgactattcc 5220 ccggggttgg cggggagtgg ggacatgagt tggtctgcct gttgtggggc cgggaagggg 5280 agggagtcag gcacaagtgg cctctttgtt tggtcttaaa ggcatccatt tctgggaatg 5340 aagccatgtt cgctgctaac acttttggat gttgtgaggc cacgtggagt gtgtgagaga 5400 ctaggtttta tggatggtct ggttcaggta ccaggtctgc tggaaggttc ctgttcggat 5460 aagctggtag ctacctagct ctgagcctgc cttcaagaac acctgtgttc atcctctgat 5520 tctctgtgtg tacctcttgt ggcgtttcct ctcccgggtg tgaacatcct aaccgttatt 5580 gtgcaaaccc aagaacgtca gatcccaaag cacaacaacc tggatggact ttgggaacat 5640 ctaagcaatg taagagagag gtgcactgag agtacgtctt ggtcccctcc accctgagag 5700 catctgacgg tcctcagtac tgaactcccg gaagctgctc tgagcccggt gacctcatct 5760 gggccaggtg tggtgcctga gctgaatgct caggtgctta cagtgttgca atccctaaga 5820 gagtagagtc tggaggagaa accgtgaaaa agaccttaca caccaccaag aacttccgaa 5880 tgggcgtgaa tccaccgttt cttctctttg caaaaagaac caccacagct gctcaaagaa 5940 cacagtgaac tcatcacttt ggttcatcaa aaaatcatcg cccatgcgtt attcctgagt 6000 gcattttctt acaacttttt gactgcttcc ttttcttctt ctcttaagag ttgtgggctt 6060 aagaatggga tagagtcata atggcaacct ccaagccctc tcaattcttg attaagaaca 6120 caggtagaca tgaatcccaa ttgtctattg ctatcttatt tatatgattc gggaaaatac 6180 agcatgtaaa aatattgctg aggagcctca gtgattgggt acaagaagca agagtacaga 6240 aattattttt gccaaattta ttttgtaaat atgagggtct gtacctaaat ttaaaaaaaa 6300 aaacacgtag aactaggtat tttgttctct tcttagtaaa tttgtagtgg ttgtatacta 6360 cactagctgc aattttcaca tttttctaat tcagaaaggt ttttcttata ttaggggaaa 6420 aagtatttat tttaatatat aaaatcactc tgaaaatcac tctcataaaa aatggagcgc 6480 atgtaaattt ttatcaaaga aaaataaaca ggtgaatggg ggatagtgat tttctttttt 6540 cagcacagtc tacctcagtg tattgttaag atgtgattca atcatggaca tctttgagat 6600 ttcagaattc tacctggaac cggtctgaat cagggaacgt gtgtatcagc tgattcgaat 6660 gccagggacc agtaagaatt ttgagggagg gagttgggat ggagaaggta tggcctttat 6720 gcgagcatag atccttttct tcctggctgg taatattctt ctctgaattt aatcttcctt 6780 taaaaaaaaa tcctccatct attgtcacta tgttccccaa acataaacta agttccaggc 6840 tgtcatgatg tatctgatat atggggtaac ccagcaaggt gtaccttcct ttggtgagag 6900 atggctgccg gggcaaagac gggctttgat tcagaacaag cattcccacc tgttccatgg 6960 aatccccctg aagtgagcac aaaggtgccc tgggctccct gatggtttat gcccactcct 7020 ttcaggctgg tgatgcacct tacacacaaa cacctaatgc aatgtctttt taaattctcc 7080 aagtgggatg ggagcatgtg agggaaattc caatccaaaa cccattaatg tgctgaacgc 7140 ttttcttctc tccccctttt ttttgcaaca acaccttgga cctctgtgtt ggggtttgac 7200 tgacctcaag ctgatattat tggaccttgt gcagctttga taacccatgt gagagtctag 7260 gcaggaccag tggggcccaa atcttgctgc tcttgtactt ttaggcactg cccttgcaga 7320 ctcacctttc tccacctgcc ctggagaaag gtagggtgtg ctgggcctgc cccttgcaaa 7380 tgggattcac cagtttcatt tatttgactc tactgccaca gtgaaaagag caaacagcta 7440 ttgggttgca aacctccttt gacattagga aatgttgact ttgtaacaat aaaactttgg 7500 tcctagaaag acacggttgt cctgggagtt tgtagtgtta agttgcagca acaacaacaa 7560 aaagcaacaa aaccagctta ggataacact ttttgttgct tgttcttaaa gatgtctcac 7620 tatgattaaa acccttttca ttaatgtagt gaaagccaca caggagttcc ttcttccagg 7680 aggagaatac caagcacatc actttctctc tgcatcagtg atgtcaaata cgcatcagaa 7740 aatgttcagg ttttaggagc tgtcctaggt gctgtttcat cattggaagc agtgagaaag 7800 agaagcactg ctgcttgtct ggatataggc tgaggatgat tgagagaagc tgtgggaact 7860 gacacaaggg tctgcatagg tcatcctgtg accctgggga ctatgttacc aactgacaga 7920 cagatctttc actgtatcct agcagggcag gtagtccacc aagaaatgtg cttattggat 7980 tgggaggtgt ttatttgtag tctgctgtaa cacgtgtgaa agagcaggag cgtcatcagc 8040 atatgacttg cgctggtcat ccggtaaatg gatgtgctgt agtcccagtg ctaatcattt 8100 ctctccttca cagtgggtgg aagtttaggg ttaaatgtcc tttgaatgtc acctggtgag 8160 tccttgacac cttaggctct tcagaaacaa tggttttgtt gaggatgggg aacagggaat 8220 gccgatttta tatacatggt acacagagag gggtgtcact tcagaaaatc ttccagcatg 8280 ttcttcagaa tattaattta tatgcgaggt gaggttggga atgaaaagaa caggtcagca 8340 cttttttttt tcctagaaca tacaaaagaa catggtggac tttcagggag tgcaatggaa 8400 ggtgaatatt tccttaaggg tccccgagaa atgggagtga ggggagggga cacaatggct 8460 ttttgagctt acttttacct tctgatacta gtcaaggtcc agaaccagcc accagccaaa 8520 tttctatctg ggtgcgggcc actgaaaatc cttgttaaaa accagatcac aaatctgtgg 8580 ctcttggtcc cattggagaa ggaaggaaga gcctcaaaat aagtgtgcat ccatgcacat 8640 attcaggaac agcttgttta gtctttacac tttgcctgaa agttgcttct cctcgtccct 8700 ttgtgtgcct gggtggcctc ggccctgtgc gttggcaacg caggatcaaa tgtgctgcag 8760 cttttgcaga aaacaactca gaaacacaaa accccccaac agctcaatta ttattttttc 8820 aatgttttcc tacaagagcc aagtagcacc atgtacagaa gacgcctttt tttttggaat 8880 attgaaatcg ttctgcatgt aaaatatggg ataatgacct gtttatatta aaattctgat 8940 taaattatct g 8951 <210> 225 <211> 4779 <212> DNA <213> Homo sapiens <400> 225 cattcactat ccaagctgca ccatcttcgg ggtcattgtg tgccaggcat atcaactctt 60 ttcaataaaa atggatggaa aggcagatgt aaagtccctc atggcgaaat ataacacggg 120 gggcaacccg acagaggatg tctcagtcaa tagccgaccc ttcagagtca cagggccaaa 180 ctcatcttca ggaatacaag caagaaagaa cttattcaac aaccaaggaa atgccagccc 240 tcctgcagga cccagcaatg tacctaagtt tgggtcccca aagccacctg tggcagtcaa 300 accttcttct gaggaaaagc ctgacaagga acccaagccc ccgtttctaa agcccactgg 360 agcaggccaa agattcggaa caccagccag cttgaccacc agagaccccg aggcgaaagt 420 gggatttctg aaacctgtag gccccaagcc catcaacttg cccaaagaag attccaaacc 480 tacatttccc tggcctcctg gaaacaagcc atctcttcac agtgtaaacc aagaccatga 540 cttaaagcca ctaggcccga aatctgggcc tactcctcca acctcagaaa atgaacagaa 600 gcaagcgttt cccaaattga ctggggttaa agggaaattt atgtcagcat cacaagatct 660 tgaacccaag cccctcttcc ccaaacccgc ctttggccag aagccgcccc taagtaccga 720 gaactcccat gaagacgaaa gccccatgaa gaatgtgtct tcatcaaaag ggtccccagc 780 tcccctggga gtcaggtcca aaagcggccc tttaaaacca gcaagggaag actcagaaaa 840 taaagaccat gcaggggaga tttcaagttt gccctttcct ggagtggttt tgaaacctgc 900 tgcgagcagg ggaggcccag gtctctccaa aaatggtgaa gaaaaaaagg aagataggaa 960 gatagatgtg ctaagaacac cttccagagc aaaataaatc aggaagagtt ggcctcaggg 1020 actcctcctg ccaggttccc taaggcccct tctaagctga cagtgggggg gccatggggc 1080 agaagtcagg aaaaggaaaa gggagacaag aattcagcca ccccgaaaca gaagccattg 1140 cctcccttgt ttaccttggg tccacctcca ccaaaaccca acagaccacc aaatgttgac 1200 ctgacgaaat tccacaaaac ctcttctgga aacagtacta gcaaaggcca gacgtcttac 1260 tcaacaactt ccctgccacc acctccacca tcccatccgg ccagccaacc accattgcca 1320 gcatctcacc catcacaacc accagtccca agcctacctc ccagaaacat taaacctccg 1380 tttgacctaa aaagtcctgt caatgaagac aatcaagatg gtgtcacgca ctctgatggt 1440 gctggaaatc tagatgagga acaagacagt gaaggagaaa catatgaaga catagnnnnn 1500 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1560 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna 1620 ggccctattc aagtcatcca tcttgcaaaa gcttgttgtg atgtcaaagg aggaaagaat 1680 gaactgagct tcaagcaagg agagcaaatt gaaatcatcc gcatcacaga caacccagaa 1740 ggaaaatggt tgggcagaac agcaaggggt tcatatggct atattaaaac aactgctgta 1800 gagattgact atgattcttt gaaactgaaa aaagactctc ttggtgcccc ttcaagacct 1860 attgaagatg accaagaagt atatgatgat gttgcagagc aggatgatat tagcagccac 1920 agtcagagtg gaagtggagg gatattccct ccaccaccag atgatgacat ttatgatggg 1980 attgaagagg aagatgctga tgatggctcc acactacagg ttcaagagaa gagtaatacg 2040 tggtcctggg ggattttgaa gatgttaaag ggaaaagatg acagaaagaa aagtatacga 2100 gagaaaccta aagtctctga ctcagacaat aatgaaggtt catctttccc tgctcctcct 2160 aaacaattgg acatgggaga tgaagtttac gatgatgtgg atacctctga tttccctgtt 2220 tcatcagcag agatgagtca aggaactaat tttggaaaag ctaagacaga agaaaaggac 2280 cttaagaagc taaaaaagca ggaaaaagaa gaaaaagact tcaggaaaaa atttaaatat 2340 gatggtgaaa ttagagtcct atattcaact aaagttacaa cttccataac ttctaaaaag 2400 tggggaacca gagatctaca ggtaaaacct ggtgaatctc tagaagttat acaaaccaca 2460 gatgacacaa aagttctctg cagaaatgaa gaagggaaat atggttatgt ccttcggagt 2520 tacctagcgg acaatgatgg agagatctat gatgatattg ctgatggctg catctatgac 2580 aatgactagc actcaacttt ggtcattctg ctgtgttcat taggtgccaa tgtgaagtct 2640 ggattttaat tggcatgtta ttgggtatca agaaaattaa tgcacaaaac cacttattat 2700 catttgttat gaaatcccaa ttatctttac aaagtgttta aagtttgaac atagaaaata 2760 atctctctgc ttaattgtta tctcagaaga ctacattagt gagatgtaag aattattaaa 2820 tattccattt ccgctttggc tacaattatg aagaagttga aggtacttct tttagaccac 2880 cagtaaataa tcctccttca aaaaataaaa ataaaagaaa aaggaaaatc attcaggaag 2940 aaatgacctg tctaaaaaaa cctaaggaag aataataata taagaaagga aatttaaaaa 3000 cattccacaa gaagaaaaat tattgtttat actcctactt atggttatat cttatattct 3060 ctattcaagt gacctgtctt ttaaaaaggc agtgctgtct tacctcttgc tagtgggtta 3120 aatgttttca aaaattatag cagtagtaga agttttgtat aaaatttgtc cttatttgtt 3180 aattgtatat aaatgttaat tatttgatac gaatgttatg catttagtat gcacattgaa 3240 gtctaaactg tagaagagtc taaaacaagt tctctttttg cagattcaca tactaatggt 3300 ttaattctgt gctctgttta aagtactatt ataactagag tagatctgaa tgaggataac 3360 cctaaaatca tgaggaatgg aagaatggac cttgaaacta cctaggcttt tatgcatggc 3420 acctctttat aatgaagaca ctttttaaag tttttgtttt tgtttcaatt accgctagat 3480 ttttttttct ctttttttaa aatccatttt actggaaagt tggccagcag agggagtaga 3540 aattattaaa attctagtgt ttggattggg cccttctcta acagtacata ctcattccca 3600 aagcaatcca aaaacaaaat gtgaaccatt tgggtttcaa atgttaagaa cactaaatag 3660 catgatttaa aaaatgaaaa atgctaacac ccaagaaaag aagatattaa gtgcttttta 3720 acaactccta gagtacaaaa tgagtacatc ataatgctgg ctcttctact aatgaaccat 3780 cgagtgatat tgaataaatt atttatcttc tcagtttcct tatctgtaaa ttacaatatt 3840 agactaagta agtttttcca actcttcact accaattacc ttaggctttt ataatgctcc 3900 gcctacttca gtcccatgtt tcagaagctt ttgtctattt tttaaactca ttgattaaat 3960 aatgattaat gcattctcca cattttaata ttgcaaaggc ccattggagt ttctgaagtg 4020 gctccacaga attgaaataa tttcaaataa ctgtaaagga actgaaaatc ttcacagaga 4080 tgaagtgggg tttccattag gtgctttgaa atttgataac aaatcatcaa cttccactgg 4140 tcaatatata gattttgggt gtctgaggcc ccaagattag atgccactaa tctccaaaga 4200 ttccctccaa ttatgaaata ttttaatgtc tacttttaga gagcactagc cagtatatga 4260 ccatgtgatt aatttctttt cacactagat aaaattacct ggttcaaaag tggtttttgt 4320 ttattaaatt tggtaataaa tatatataat acacagacag gatagttttt atgctgaagt 4380 ttttggccag ctttagtttg aggactcctt gataagcttg ctaaactttc agagtgccct 4440 gagacacttc cagccatccc tcctcctgcc ttcattgggg cagacttgca ttgcagtctg 4500 acagtaattt tttttctgat tgagaattat gtaaattcaa tacaatgtca gtttttaaaa 4560 gtcaaagtta gatcaagaga atatttcaga gttttggttt acacatcaag aaacagacac 4620 acatacctag gaaagattta cacaatagat aatcatctta atgtgaaaga tatttgaagt 4680 attaatttta atatattaaa tatgatttct gttatagtct tctgtatgga attttgtcac 4740 ttaagatgag ctgcaaataa ataatacctt caatggaaa 4779 <210> 226 <211> 2341 <212> DNA <213> Homo sapiens <400> 226 gtacataggc atcttattca ctgcaccctg tcacacccag caccccccgc cccgcacatt 60 atttgaaaga ctgggaattt aatggttagg gacagtaaat ctacttcttt ttccagggac 120 gactgtcccc tctaaagtta aagtcaatac aagaaaactg tctattttta gcctaaagta 180 aaggctgtga agaaaattca ttttacattg ggtagacagt aaaaaacaag taaaataact 240 tgacatgagc acctttagat cccttcccct ccatgggctt tgggccacag aatgaacctt 300 tgaggcctgt aaagtggatt gtaatttcct ataagctgta atagtggagg tattgtgggt 360 tcatttgagt aagccctcca aagataccat tcaaataacc tgggagaatg tcataaatta 420 ttcagataat taacactgca tgaatctgat tcagaggcat gcgtttacat atgttgccct 480 aattaccatt tgatgatcat aaatacaagt gaatgacatt ggacttttag taacaaactt 540 aatttttaaa aaggtgtaga caatggtggt taaaaaaaaa aaaaaacagg taccaggttc 600 tgtgtgtttg caccaagtaa ttgacatgtt ttttgtttaa tacatgtgga ccatgaacag 660 tattcattct cctttttcaa atgatatgct gtagaaaata ttccttgaag atgtgagatt 720 taaaaatttt tccctttcaa tgttgtttta attgtatttc ttacttggtt tttttgattg 780 atagcacagt gataaatcat aatactagac aaaattgtct tctctttcaa accagagcca 840 tatatatgtc tgtatatatg ggacctactg cttctctgag gaaatgcata atctgttaat 900 atcagacaaa atgagcaatt ggcagtgctc ataatatatt ccaattttta ttggaatttt 960 cgatggaatg ttatttcaat aaagccatgt aaggtgaaac tttgataact ttttactctt 1020 caagttaggg taaattctga tccaatattc aattcatttg tgtactccca catgcaaaat 1080 gctaaattac aatgcagaca ttaagaaaaa gtattgactg gaggggttga attccttgag 1140 aatttatttt atagtctaaa tcacaaatac tttactcaat ttagttttta aaatagtaaa 1200 ctgaatattt ttgttgtaag cctatcagag tcaatccttc gtttggaatt gttttcctgt 1260 ttttccttac tataaatcat ttaaaaactg aattcatttt cttagatggc ataagtctgt 1320 ctcttgagaa ataagtaaaa tactcctatt ttcagtatct gtagcacctg aaataggtct 1380 ttgtatagcc agaaacaagt tatgttgaag ttagcttttc tttgtcaaca gttttggaca 1440 ataaaaatct gaaagtatta acacttgatt ttctactggg gcccttcaaa cttggttgga 1500 agaaattcaa ccagaatatc tacattagag tataatcatg tgtggtagga agatggacta 1560 gttaatcaag atttgttgtc acttaaattt tttgtgattt ttttccaagc cagttttttt 1620 aaattctaaa tgtgttttga ggtatgggta cattaattgt aatgtaaact attatacaac 1680 tgtttttgcg actttatagg caggtaaatt ttgctattac tattgaatac aaatgacaat 1740 tcatttatga ccactcaaac agcgttagta accatttagt gacaaaggat taaaacatcc 1800 atctggatgt taattttgaa gatgtaaatt atatgttgtt taaatttttc caggcatctg 1860 aaaaccttat ctgctagaca atgtaagatt cacacagagt tatctgggat tctgattttt 1920 taaatagtac atatcattaa accattttct ctaaatgtaa gaagagcaga aaaaatctta 1980 taagattatc agatttttct aatgacacag aaatgtaaga aaaaaatccc tttatattga 2040 aaaaagatgc agtcaaagtc ttttcagaca tgcccaaact ttgagaattt cttcaaccat 2100 ctaatgctat aaagattttt gttcttcctg ttcacaacca gttgtataac agaaatacta 2160 gctactgttt tccttcctgt gtgtgaagta atgaatcatt gattatgtga cttgttatgt 2220 attcaattaa acactaaaga ataaaacatt cactccttta attattcgaa aaaaaatcta 2280 tgtcgggtgc ggagaaagag gtaatgaaat ggcaggaatt cgatatcagc ttatcatacc 2340 t 2341 <210> 227 <211> 2070 <212> DNA <213> Homo sapiens <400> 227 ctgagaaccg ggcagacccc ttcgaccaag gtgtcgtggc cacggacgag gtgaaggagg 60 agcccccgga gccattccag aaaatcgggc caatgaacaa tattacatca gacattttta 120 agaagaaaga agttaggcag tgccaaaaga gagaaactgg caattacacc tgtgaattct 180 gcggcaaaca gtacaagtac tacactccct accaggagca tgtggcctta cacgccccca 240 tcaaaagcgc tttcagtcgg agagtagaag gcaaagcaca aaaccacttt gaagagacga 300 acagcagttc gcagaactcc agcgaaccct acacctgcgg cgcctgtggg atccagttcc 360 agttctacaa caacctgttg gagcacatgc agtcccatgc agctgagcaa tgaaaacaac 420 attgcctcca accagtcccg atcgccacct gctgttgtag aagagaagtg gaaacctcag 480 gcccagagga acagtgccaa taacaccact accagtggtt taacacccaa cagcatgatc 540 cccgaaaagg agcggcagaa catcgcagag cggctgttga gggtcatgtg tgccgacctg 600 ggtgcactga gcgtggtcag cgggaaggag ttcctgaagt tggcccagac cttagtagac 660 agtggtgccc gctatggggc cttctcggtc actgaaatcc tgggcaactt caacacgctg 720 gcgctgaagc acctgccacg catgtacaac caggtgaagg tgaaagtgac ctgtgccttg 780 ggcagcaatg cctgcctagg catcggtgtc acctgccact cccagagtgt tggccctgac 840 tcctgctaca tcctcacagc ctaccaggcc gagggcaacc acatcaagag ctatgtgctt 900 ggtgtgaagg gtgcggacat tcgcgacagc ggtgaccttg tgcaccactg ggtgcagaac 960 gtgctgtcgg agttcgtgat gtcggagatc aggacagtgt acgtgacgga ttgccgggtg 1020 agcacgtccg ccttctccaa ggccggcatg tgccttcgct gctcagcctg tgccttgaac 1080 tcggtggtgc agagcgtgct gagcaagcgg acactgcagg cccgcagcat gcacgaggtc 1140 atcgagctgc tcaacgtgtg cgaggacctg gcgggctcca cgggcctggc caaggagacc 1200 ttcgggtcgc tggaggagac gtctccacca ccctgctgga actcggtgac ggactcactg 1260 ttgctggtgc atgagcgcta tgagcagatc tgcgagttct acagccgggc caagaagatg 1320 aacctcatcc agagcctcaa caagcacctg ctcagcaacc tggcggccat cctgacgccg 1380 gtgaagcagg cagtcatcga gctgagcaac gagagccagc ccaccctgca gctggtgctg 1440 cccacctacg tcaggctgga gaagctgttc acggccaagg ccaacgacgc aggcactgtc 1500 agcaagctct gccacctctt cctggaggcg ctcaaggaga acttcaaggt gcacccggcc 1560 cacaaggtgg ccatgatcct ggacccgcag cagaagctgc ggcctgtgcc accctaccag 1620 cacgaggaga tcatcggcaa ggtctgtgag ctcatcaacg aggtgaagga gtcctgggcc 1680 gaggaggccg acttcgagcc cgctgccaag aagccccgct ctgctgccgt cgagaacccc 1740 gcagctcagg aagatgatcg gctaggcaaa aatgaagtgt acgattacct gcaggagccc 1800 ctcttccagg ctacccctga tctcttccag tactggtcgt gcgttaccca aaagcacaca 1860 aaactcgcca agctcgcctt ctggctcctg gcggttccgg ccgtgggcgc cagaagcggg 1920 tgtgtaaata tgtgtgaaca agcgcttcta atcaaacgga ggcggctgct cagtccagaa 1980 gatatgaata aactcatgtt tctgaaatcc aacatgcttt aagacttgac ttcgggggaa 2040 aaaaaaagaa aaagagaaga taacntttag 2070 <210> 228 <211> 759 <212> DNA <213> Homo sapiens <400> 228 cgcgatctag aaggaggaga acgggcggag ggcgcgggcc gaccgggcgc accgaccatg 60 gcctccaaat gccccaagtg cgacaagacc gtgtacttcg catgacggga agccgttctg 120 ccacaagccg tgctacgcca ccctgttcgg acccaaaggc gtgaacatcg ggggcgcggg 180 ctcctacatc tacgagaagc ccctggcgga ggggccgcag gtcaccggcc ccatcgaggt 240 ccccgcggcc cgagcagagg agcggaaggc gagcggcccc ccgaaggggc ccagcagagc 300 ctccagtgtc accactttca ccgggggagc ccaacacgtg cccgcgctgc agcaagaagg 360 tgtacttcgc tgagaaggtg acgtctctgg gcaaggattg gcaccggccc tgcctgcgct 420 gcgagcgctg cgggaagaca ctgacccccg gcgggcacgc ggagcacgac ggccagccct 480 actgccacaa gccctgctat ggaatcctct tcggacccaa gggagtgaac acccacctgc 540 cagtgttatt tatgctccct tcgtgggtga tggccacgcc ctcaccatgt ccctggcaga 600 gggcttccct ccgggatccc ctgcctggtg cccacactgc ctcgcaagcg ctcgccaccc 660 tcacgtggct cacctgctgt tgagccttgt gctgtcaatc cacggtttga gggttgcaaa 720 aaaaatctat gtcggtgcgg agaaagaggt aatgaaatg 759 <210> 229 <211> 4036 <212> DNA <213> Homo sapiens <400> 229 ccgaggctgc agcagcgcat cccggggcat ggcgcggcgg gggcgcggag ggctcggttc 60 ggagggggcc gggagcccgg gcgccctgga gtgaggagga ccgggagctg gctctggagg 120 ctgcggaggc gacgccggag agaacgaagc ctcggctggg agcggatctt tcgaagatgg 180 tttggctgcc ttggagattt ggagatctga tgccacgatg aggactcaca cacggggggc 240 tcccagtgtg tttttcatat atttgctttg ctttgtgtca gcctacatca tcgacgagaa 300 cccagaagtt atgattccct tcaccaatgc caactacgac agccatccca tgctgtactt 360 ctccagggca gaagtggcgg agctgcagct cagggctgcc agctcgcacg agcacattgc 420 agcccgcctc acggaggctg tgcacacgat gctgtccagc cccttggaat acctccctcc 480 ctgggatccc aaggactaca gtgcccgctg gaatgaaatt tttggaaaca aacttgggtg 540 cctgtgtgca aatgttcttg tgtgctgtat cctgagaaca ttgaagcccg agaatggcca 600 aaagactaca tggagaggat ggcagcgcag cctagttggt tggtgaaaga tgctccttgg 660 gatgaggtcc cgcttgctca ctccctggtt ggttttgcca ctgcttatga cttcttgtac 720 aactacctga gcaagacaca acaggagaag tttcttgaag tgattgccaa tgcctcaggg 780 tatatgtatg aaacttcata caggagagga tggggatttc aatacctgca caatcatcag 840 cccaccaact gtatggcttt gctcacggga agcctagtcc tgatgaatca aggatatctt 900 caagaagcct acttatggac caaacaagtt ctgaccatca tggagaaatc tctggtcttg 960 ctcagggagg tgacggatgg ctccctctat gaaggagttg cgtatggcag ctacaccact 1020 agatcactct tccaatacat gtttctcgtc cagaggcact tcaacatcaa ccactttggc 1080 catccgtggc ttaaacaaca ctttgcattt atgtatagaa ccatcctgcc agggtttcaa 1140 aggactgtgg ctattgcgga ctcaaattac aactggtttt atggtccaga aagccaatta 1200 gtgttccttg ataaatttgt catgcgtaat ggcagtggta actggctagc tgaccaaatc 1260 agaaggaacc gtgtggtgga aggtccagga acaccatcca aagggcagcg ctggtgcact 1320 ctgcacacag aatttctctg gtatgatggc agcttgaaat cggttcctcc tccagacttt 1380 ggcaccccta cactgcatta ttttgaagac tggggtgtcg tgacttatgg aagtgcacta 1440 cctgcagaaa tcaatagatc tttcctttcc ttcaagtctg gaaaactggg gggacgtgca 1500 atatatgaca ttgtccacag aaacaaatac aaagattgga tcaaaggatg gagaaatttt 1560 aatgcagggc atgaacatcc tgatcaaaac tcatttactt ttgctcccaa tggtgtgcct 1620 ttcattactg aggctctgta cgggccaaag tacaccttct tcaacaatgt tttgatgttt 1680 tccccagctg tgtcaaagag ctgcttttct ccctgggtgg gtcaggtcac agaagactgc 1740 tcatcaaaat ggtctaaata caagcatgac ctggcagcta gttgtcaggg gagggtggtt 1800 gcagcagagg agaaaaatgg ggtggttttc atccgaggag aaggtgtggg agcttataac 1860 ccccagctca acctgaagaa tgttcagagg aatctcatcc tcctacatcc acagctgctt 1920 ctccttgtag accaaataca cctgggagag gagagtccct tggagacagc agcgagcttc 1980 ttccataatg tggatgttcc ttttgaggag actgtggtag atggtgtcca tggggctttc 2040 atcaggcaga gagatggtct ctataaaatg tactggatgg acgatactgg ctacagcgag 2100 aaagcaacct ttgcctcagt gacatatcct cggggctatc cctacaacgg gacaaactat 2160 gtgaatgtca ccatgcacct ccgaagtccc atcaccaggg cagcttacct cttcataggg 2220 ccatctatag atgttcagag cttcactgtc cacggagact ctcagcaact ggatgtgttc 2280 atagccacca gcaaacatgc ctacgccaca tacctgtgga caggtgaggc cacaggacag 2340 tctgcctttg cacaggtcat tgctgatcgt cacaaaattc tgtttgaccg gaattcagcc 2400 atcaagagca gcattgtccc tgaggtgaag gactatgctg ctattgtgga acagaacttg 2460 cagcatttta aaccagtgtt tcagctgctg gagaagcaga tactgtcccg agtccggaac 2520 acagctagct ttaggaagac tgctgaacgc ctgctgagat tttcagataa gagacagact 2580 gaggaggcca ttgacaggat ttttgccata tcacagcaac agcagcagca aagcaagtca 2640 aagaaaaacc gaagggcagg caaacgctat aaatttgtgg atgctgtccc tgatattttt 2700 gcacagattg aagtcaatga gaaaaagatt agacagaaag ctcagatttt ggcacagaaa 2760 gaactaccca tagatgaaga tgaagaaatg aaagaccttt tagattttgc agatgtaaca 2820 tacgagaaac ataaaaatgg gggcttgatt aaaggccggt ttggacaggc acggatggtg 2880 acaactacac acagcagggc cccatcactg tctgcttcct ataccaggtt gttcctgatt 2940 ctgaacattg ctattttctt tgtcatgttg gcaatgcaac tgacttattt ccagagggcc 3000 cagagcctac atggccaaag atgtctttat gcagttcttc tcatagatag ctgtatttta 3060 ttatggttgt actcttcttg ttcccaatca cagtgttagc actgaagcta taaattacct 3120 ggtcattttg tgatcacaag agtctatgca aaaaaaaaat ttctttaccc cagattatca 3180 gatttttttc cctcagattc attttaacaa attaagggaa gatattttga cacaagaaag 3240 caggaacgtg gagaaattgg agcaggaaaa gaaattatca aagcaataga aatagcttgg 3300 tggtcctatg gtgtttttgg aagtatttgg cattgctaat tgagcagtcc atatagtact 3360 acttttagaa gaaacaaaaa gtctgttttt taaagtaatg ttttttctta tgagaaaaag 3420 gtttagatag aattgggttt tattaatatt aatttaatgc tattagcaat ttccatatac 3480 tatattgtgg aaaagactga agaatacaat tctgagaaat ataaaaaaat tttaatggta 3540 tactcatgtt gaaagataaa tgttgctaag tcctggtatg atggtgtgag cttccttggg 3600 gaagtacttc ttgagttatg taactaacag gatgttttac tacagatctg gatggctatt 3660 cagataacat ggcaaaaaat gatagcagaa gatcattaaa aacttaaaat atattttatt 3720 agaaaacatt tatctatgaa tgaatatttc cttgatgctg gtctctgcac acatatgctt 3780 ggttacttgc atgcattcat tggttgttca ataagtgaga tgattacaga taatactgta 3840 ttttccttat atggaaaacc gttatagacc caataacaac taaacctttc aaaagaaaat 3900 attttctatt atgaatgttg attttcatac caaagaagat ggagagtcta aaatttggat 3960 atgattctta tgttttttta atagaaaacc ttcttcaagt ttattttcct aaataaacat 4020 cataattgtg aatttt 4036 <210> 230 <211> 2400 <212> DNA <213> Homo sapiens <400> 230 gcctcccgcc cgccgcctct gtctccctct ctccacaaac tgcccaggag tgagtagctg 60 ctttcggtcc gccggacaca ccggacagat agacgtgcgg acggcccacc accccagccc 120 tccaactagt cagcctgcgc ctggcgcctc ccctctccag gtccatccgc catgtggccc 180 ctgtggcgcc tcgtgtctct gctggccctg agccaggccc tgccctttga gcagagaggc 240 ttctgggact tcaccctgga cgatgggcca ttcatgatga acgatgagga agcttcgggc 300 gctgacacct cgggcgtcct ggacccggac tctgtcacac ccacctacag cgccatgtgt 360 cctttcggct gccactgcca cctgcgggtg gttcagtgct ccgacctggg tctgaagtct 420 gtgcccaaag agatctcccc tgacaccacg ctgctggacc tgcagaacaa cgacatctcc 480 gagctccgca aggatgactt caagggtctc cagcacctct acgccctcgt cctggtgaac 540 aacaagatct ccaagatcca tgagaaggcc ttcagcccac tgcggaagct gcagaagctc 600 tacatctcca agaaccacct ggtggagatc ccgcccaacc tacccagctc cctggtggag 660 ctccgcatcc acgacaaccg catccgcaag gtgcccaagg gagtgttcag tgggctccgg 720 aacatgaact gcatcgagat gggcgggaac ccactggaga acagtggctt tgaacctgga 780 gccttcgatg gcctgaagct caactacctg cgcatctcag aggccaagct gactggcatc 840 cccaaagacc tccctgagac cctgaatgaa ctccacctag accacaacaa aatccaggcc 900 atcgaactgg aggacctgct tcgctactcc aagctgtaca ggctgggcct aggccacaac 960 cagatcagga tgatcgagaa cgggagcctg agcttcctgc ccaccctccg ggagctccac 1020 ttggacaaca acaagttggc cagggtgccc tcagggctcc cagacctcaa gctcctccag 1080 gtggtctatc tgcactccaa caacatcacc aaagtgggtg tcaacgactt ctgtcccatg 1140 ggcttcgggg tgaagcgggc ctactacaac ggcatcagcc tcttcaacaa ccccgtgccc 1200 tactgggagg tgcagccggc cactttccgc tgcgtcactg accgcctggc catccagttt 1260 ggcaactaca aaaagtagag gcagctgcag ccaccgcggg gcctcagtgg gggtctctgg 1320 ggaacacagc cagacatcct gatggggagg cagagccagg aagctaagcc agggcccagc 1380 tgcgtccaac ccagcccccc acctcaggtc cctgacccca gctcgatgcc ccatcaccgc 1440 ctctccctgg ctcccaaggg tgcaggtggg cgcaaggccc ggcccccatc acatgttccc 1500 ttggcctcag agctgcccct gctctcccac cacagccacc cagaggcacc ccatgaagct 1560 tttttctcgt tcactcccaa acccaagtgt ccaaggctcc agtcctagga gaacagtccc 1620 tgggtcagca gccaggaggc ggtccataag aatggggaca gtgggctctg ccagggctgc 1680 cgcacctgtc cagacacaca tgttctgttc ctcctcctca tgcatttcca gcctttcaac 1740 cctccccgac tctgcggctc ccctcagccc ccttgcaagt tcatggcctg tccctccaag 1800 acccctgctc cactggccct tcgaccagtc ctcccttctg ttctctcttt ccccgtcctt 1860 cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920 nnnnnnnnnn nnnnnnnnnn ntgtgcttcc tcagaccttt ctcgcttctg agcttggtgg 1980 cctgttccct ccatctctcc gaacctggct tcgcctgtcc ctttcactcc acaccctctg 2040 gccttctgcc ttgagctggg actgctttct gtctgtccgg cctgcaccca gcccctgccc 2100 acaaaacccc agggacagcg gtctccccag cctgccctgc tcaggccttg cccccaaacc 2160 tgtactgtcc cggaggaggt tgggaggtgg aggcccagca tcccgcgcag atgacaccat 2220 caaccgccag agtcccagac accggttttc ctagaagccc ctcaccccca ctggcccact 2280 ggtggctagg tctcccctta tccttctggt ccagcgcaag gaggggctgc ttctgaggtc 2340 ggtggctgtc tttccattaa agaaacaccg tgcaacgtga aaaaaacagc aagtcgggct 2400 <210> 231 <211> 2441 <212> DNA <213> Homo sapiens <400> 231 gggggggaaa gaaaggggtg tggggaggcc aaggctctgt gaaacccccg acgtgaagcg 60 aaagttctcc tcccagggag gttttcgagg aaaagcgctt ttctgcgctg cctaggagac 120 ctgcgtaccc tcccgaagcc gaacagttgc tcggagcagt cggcttggcg ccgcgagcgc 180 cgggtgcccc tcttcggcct cccgggtttc tcggaaaggt tcccgtgtca gtggctatga 240 tgacacctca agttatcact ccccagcaaa tgcagcagat cctccagcaa caagtgctga 300 gccctcagca gctccaggtt ctcctccagc agcagcaggc cctcatgctt caacagcagc 360 agcttcaaga gttttataaa aaacaacagg aacagttgca gcttcaactt ttacaacaac 420 aacatgctgg aaaacagcct aaagagcaac agcaggtggc tacccagcag ttggcttttc 480 agcagcagct tttacagatg cagcagttac agcagcagca cctcctgtct ttgcagcgcc 540 aaggccttct gacaattcag cccgggcagc ctgcccttcc ccttcaacct cttgctcaag 600 gcatgattcc aacagaactg cagcagctct ggaaagaagt gacaagtgct catactgcag 660 aagaaaccac aggcaacaat cacagcagtt tggatctgac cacgacatgt gtctcctcct 720 ctgcaccttc caagacctcc ttaataatga acccacatgc ctctaccaat ggacagctct 780 cagtccacac tcccaaaagg gaaagtttgt cccatgagga gcacccccat agccatcctc 840 tctatggaca tggtgtatgc aagtggccag gctgtgaagc agtgtgcgaa gatttccaat 900 catttctaaa acatctcaac agtgagcatg cgctggacga tagaagtaca gcccaatgta 960 gagtacaaat gcaggttgta cagcagttag agctacagct tgcaaaagac aaagaacgcc 1020 tgcaagccat gatgacccac ctgcatgtga agtctacaga acccaaagcc gcccctcagc 1080 ccttgaatct ggtatcaagt gtcactctct ccaagtccgc atcggaggct tctccacaga 1140 gcttacctca tactccaacg accccaaccg cccccctgac tcccgtcacc caaggcccct 1200 ctgtcatcac aaccaccagc atgcacacgg tgggacccat ccgcaggcgg tactcagaca 1260 aatacaacgt gcccatttcg tcagcagata ttgcgcagaa ccaagaattt tataagaacg 1320 cagaagttag accaccattt acatatgcat ctttaattag gcaggccatt ctcgaatctc 1380 cagaaaagca gctaacacta aatgagatct ataactggtt cacacgaatg tttgcttact 1440 tccgacgcaa cgcggccacg tggaagaatg cagtgcgtca taatcttagt cttcacaagt 1500 gttttgtgcg agtagaaaac gttaaagggg cagtatggac agtggatgaa gtagaattcc 1560 aaaaacgaag gccacaaaag atcagtggta acccttccct tattaaaaac atgcagagca 1620 gccacgccta ctgcacacct ctcaatgcag ctttacaggc ttcaatggct gagaatagta 1680 tacctctata cactaccgct tccatgggaa atcccactct gggcaactta gccagcgcaa 1740 tacgggaaga gctgaacggg gcaatggagc ataccaacag caacgagagt gacagcagtc 1800 caggcagatc tcctatgcaa gccgtgcatc ctgtacacgt caaagaagag cccctcgatc 1860 cagaggaagc tgaagggccc ctgtccttag tgacaacagc caaccacagt ccagattttg 1920 accatgacag agattacgaa gatgaaccag taaacgagga catggagtga ctatcggggc 1980 gggccaaccc cgagaatgaa gattggaaaa aggaaaaaaa aaaaacacgt caaaagttag 2040 cagtgaaatt gttctccatt tgttgtacag tctggaggat tttcactacg ttttgacaac 2100 tctgaaatgt gttaactctt agtgccatca agaaccccat ttgggagtat ttttgatttt 2160 tctacttttt gttgaaaaaa ggaatttgta ctctgtgcat tggatggact tgtttggtac 2220 ttgggatttt cctctcttaa ccgtcaacat cagtgttgta aatttgctaa actgattcac 2280 ttttagcagc agactttgaa ctgcagtcct gccaacgttg gacactgagg acgcccgaca 2340 gagcttgtgc acctaagctg cagaccaagc ctttgcccag aatttaagga ttccaatgga 2400 cgacctattt gcacagtact gcatgttgat tatcactgcc c 2441 <210> 232 <211> 2157 <212> DNA <213> Homo sapiens <400> 232 ggctactcat cacacgctgt ggatgggact ggccctgctg ggggtgctgg gcgacctgca 60 ggcagcaccg gaggcccagg tctccgtgca gcccaacttc cagcaggaca agttcctggg 120 gcctcgcctc caactcgagc tggctccggg agaagaaggc ggcgttgtcc atgtgcaagt 180 ctgtggtggc ccctgccacg gatggtggcc tcaacctgac ctccaccttc ctcaggaaaa 240 accagtgtga gacccgaacc atgctgctgc agcccgcggg gtccctcggc tcctacagct 300 accggagtcc ccactggggc agcacctact ccgtgtcagt ggtggagacc gactacgacc 360 agtacgcgct gctgtacagc cagggcagca agggccctgg cgaggacttc cgcatgcnca 420 ccctctacag tacgtgcccc gtggacgccg cccacacgca ggcctgacca gagggngctc 480 cccaagaccc agggcagggc acacagcatc ccccccgctg aggccagctc cgtctccacc 540 ctgtcccagg ccgaacccag acccccaggg ctgagttaaa ggagaaattc accgccttct 600 gcaaggccca gggcttcaca gaggatacca ttgtcttcct gccccaaacc ggtgaggggt 660 cctaatctga tggggagagg atcaaggtca gattagaggc aggcaggcag tctcctgact 720 gggggaggca gaggggagga ggtggccccg ccctgctcga ggcctgggcc agggacagag 780 ggggtgagtg ttcaagtcag aacctccctc ccgcagcccc ttcatgagga gccccctcca 840 tgggggacat ggagaccagg cgcccactct gtgccaggcc ccagcagctc ccaggatgtg 900 gggcttcagc ctggtggggg gcatagggta gagggtgccc atgggggata caggggaacc 960 aaccatactg ggctcaggca cagcctccta ggggtggaca gcctgctctt ggcagaggtg 1020 gagaaagacc ctctctttgt ttccagtgcc cagggagagg tgggaggtga tgggggatct 1080 gtgcagtttg ggggctcagt caagacgagc tctgcgttac gggaggaaca ggaagcccag 1140 tgggaaaatt ggcctaagtc tggggttctg acgacagccc ctggcttctt tcttggcaga 1200 taagtgcatg acggaacaat aggtgagcca cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260 nnnnnnnnnn nnnnnacaca catccaccca acccactctg cgatgggatg gatcagggcc 1320 ccaggacagc ctggtgctgc agacccatcc ttcccgatgg ctgcagtcca gggccgggcg 1380 ggagacactg gggctgccca cattgatggg tgcacaggtg tgaggctcag aaggaaaacc 1440 tgtcccagtg gctggaacag ggctgactcc tgaaggctca tggttggggg gtgcaggtgc 1500 gaggccccag gcagacaagg ccaaggggct ataccacagg gaccacctgg cagcaagggt 1560 gtctggctcc tgggctagga ggaaaccagg gtgggggaga caggatggga gggaacaggg 1620 gatggaaggg gagggccaag gacgctacat ggatgccgtg ggacagctcg gagagcaggc 1680 tcagggcgga ttcacccacc acccccagga gggaggccta ggctggagct ggagtctgtg 1740 gaccctgggg ctgggaaggg tggagtctgt agaccctggg gcagcgggga tccaagcccc 1800 agggatggat cttgctctct cagcggggct cagtggggct gggggcagag aaaagtcccc 1860 gtagcccgca cctgctccat cgactggagt ggaggtgggc tggggtagac tgcagtcctc 1920 catcctagcc tttcggtcac acccctcagg actccccagg gctgaagctg ggatcccggc 1980 cagccaggtg acccccacgc tctggatgtc tctgctctgt tccttccccg agcccctgcc 2040 ccggctcccc gccaaagcac ccctgcccac tcgggcttca tcctgcacaa taaactccgg 2100 aagcaagtcc cagggcttca cagaggatac cattgtcttc ctgccccaaa ccgataa 2157 <210> 233 <211> 1904 <212> DNA <213> Homo sapiens <400> 233 ggaagagccc agctgacaca accaagacga gtctcagtgt ctagggaagc ttggggttct 60 gctcctttta cttcaggcga acctgaactc agttaatgca attttgaagc atgccctgaa 120 tagattcagt cattatcaag tcaaactaaa aacggtgaaa ggttgcgact attaccaaat 180 aggaaaaacc tgaagacata agaactacac atgaggaata tgtcatttag cactttcact 240 ttttgatctc cacagaagac aatgagaagt cataccataa caatgacgac aacttcagtc 300 agcagctggc cttactcctc ccacagaatg cgctttataa ccaatcatag cgaccaaccg 360 ccacaaaact tctcagcaac accaaatgtt actacctgtc ccatggatga aaaattgcta 420 tctactgtgt taaccacatc ctactctgtt attttcatcg tgggactggt tgggaacata 480 atcgccctct atgtatttct gggtattcac cgtaaaagaa attccattca aatttatcta 540 cttaacgtag ccattgcaga cctcctactc atcttctgcc tccctttccg aataatgtat 600 catattaacc aaaacaagtg gacactaggt gtgattctgt gcaaggttgt gggaacactg 660 ttttatatga acatgtacat tagcattatt ttgcttggat tcatcagttt ggatcgctat 720 ataaaaatta atcggtctat acagcaacgg aaggcaataa caaccaaaca aagtatttat 780 gtctgttgta tagtatggat gcttgctctt ggtggattcc taactatgat tattttaaca 840 cttaagaaag gagggcataa ttccacaatg tgtttccatt acagagataa gcataacgca 900 aaaggagaag ccatttttaa cttcattctt gtggtaatgt tctggctaat tttcttacta 960 ataatccttt catatattaa gattgggaag aatctattga ggatttctaa aaggaggtca 1020 aaatttccta attctggtaa atatgccact acagctcgta actcctttat tgtacttatc 1080 atttttacta tatgttttgt tccctatcat gcctttcgat tcatctacat ttcttcacag 1140 ctaaatgtat catcttgcta ctggaaagaa attgttcaca aaaccaatga gatcatgctg 1200 gttctctcat ctttcaatag ttgcttagat ccagtcatgt atttcctgat gtccagtaac 1260 attcgcaaaa taatgtgcca acttcttttt agacgatttc aaggtgaacc aagtaggagt 1320 gaaagcactt cagaatttaa accaggatac tccctgcatg atacatctgt ggcagtgaaa 1380 atacagtcta gttctaaaag tacttgaggt aaacatacta aaatgaatta tataatgcag 1440 cctcttaatt ctttgaagaa ctaaaaaatt aggaaacaaa gttctagcat ttacaaaact 1500 cagatctcaa agctctgctt gtatttgtga tatttcattt gcttaactgt aaaccatttc 1560 aaggtactaa cttttaaatc tgtatgtaaa atcttttcaa aatacatttt taagctaata 1620 ctcttaacat agattatgaa gttaagtgaa atttatggct ctaacagcaa aataattaaa 1680 gtgccatagt ttctcaagtg actaaagtag ttattaaaat caagcacttg atactaattt 1740 gaagtgtgtt taaaagtaaa tgatttggga actgacaatg tgtcagaaaa tatatgttca 1800 tttatcattt taaaatcttg tataatttgc cactgtattc atttatgcct aaatctctat 1860 aacagatgaa aagataatta ataaaatcct aattaaaaaa tgag 1904 <210> 234 <211> 3931 <212> DNA <213> Homo sapiens <400> 234 ccaccttcca cccttccccc tcctccccag gctccacctc ccaacagggc acctcctccc 60 tcccgccctc ctccaaggcc ttctgtctag agcccaaagt tcctgctctg ggctctctca 120 gaaacttcag gagatgttag aacaagtctt tccagttaga gaagaggagt ggtgataaag 180 cccactgacc ttcacacatt ctaaaaattg gttggcaatg ccagtatacc aacaatcatg 240 atcagctgaa agaaacagat attttaaatt gccagaaaac aaatgatgag gcaactacag 300 tcagatttat agccagccat ctatcacctc tagaaggttc cagagacagt gaaactgcaa 360 gatgctctca acaggattat gtctcatgga gaccagtaag aaaatcattt atctgaaggt 420 gaaatgcaga gttggataag aaatacattg ctgggtttct aaaatgctgc cttcctgcct 480 ctactccacc tccatccctg gactttggac ccttggccta ggagcctaag gaccttcacc 540 cctgtgcacc acccaagaaa gaggaaaact ttgcctacaa ctttggaaat gctggggtcc 600 ctggtgtggt aagaaactca acatcagacg ggtatgcaga aggatgttct tctgggattt 660 gcaggtacat aaaaaatgta tggcatcttt tccttgcaaa ttcttccagt ttccaagtga 720 gaaggggagc aggtgtttac tgatggaaaa ggtatgttgc tatgttgatg tgtaagtgaa 780 atcagttgtg tgcaatagac aggggcgtat tcatgggagc atcagccagt ttctaaaacc 840 cacaggccat cagcagctag aggtggctgg ctttggccag acatggaccc taaatcaaca 900 gacaatggca ttgtcgaaga gcaacctgtt aatgaatcat gttaaaaatc aaggtttggc 960 ttcagtttaa atcacttgag gtatgaagtt tatcctgttt tccagagata aacataagtt 1020 gatcttccca aaataccatc attaggacct atcacacaat atcactagtt ttttttgctt 1080 gttagtattc gtgtatttct tggtaaagcc atgcaccaca gacttctggg cagagctgag 1140 agacaatggt cctgacataa taaggatctt tgattaaccc ccataaggca tgtgtgtgta 1200 tacaaatata cttctctttg gcttttcgac atagaacctc agctgttaac caaggggaaa 1260 tacatcagat ctgcaacaca gaaatgctct gcctgaaatt tccaccatgc ctaggactca 1320 ccccatttat ccaggtcttt ctggatctgt ttaatcaata agccctataa tcacttgcta 1380 aacactgggc ttcatcaccc agggataaaa acagagatca ttgtcttgga cctcctgcat 1440 cagcctattc aaaattatct ctctctctag ctttccacaa atcctaaaat tcctgtccca 1500 agccacccaa attctcagat cttttctgga acaaggcaga atataaaata aatatacatt 1560 tagtggcttg ggctatggtc tccaaagatc cttcaaaaat acatcaagcc agcttcattc 1620 actcacttta cttagaacag agatataagg gcctgggatg catttatttt atcaatacca 1680 atttttgtgg ccatggcaga cattgctaat caatcacagc actatttcct attaagccca 1740 ctgatttctt cacaatcctt ctcaaattac aattccaaag agccgccact caacagtcag 1800 atgaacccaa cagtcagatg agagaaatga accctacttg ctatctctat cttagaaagc 1860 aaaaacaaac aggagtttcc agggagaatg ggaaagccag ggggcataaa aggtacagtc 1920 aggggaaaat agatctaggc agagtgcctt agtcagggac cacgggcgct gaatctgcag 1980 tgccaacacc aaactgacac atctccaggt gtacctccaa ccctagcctt ctcccacagc 2040 tgcctacaac agagtctccc agccttctca gagagctaaa accagaaatt tccagactca 2100 tgaaagcaac cccccagcct ctccccaacc ctgccgcatt gtctaatttt tagaacacta 2160 ggcttcttct ttcatgtagt tcctcataag caggggccag aatatctcag ccacctgcag 2220 tgacattgct ggacccctga aaaccattcc ataggagaat gggttcccca ggctcacagt 2280 gtagagacat tgagcccatc acaactgttt tgactgctgg cagtctaaaa cagtccaccc 2340 accccatggc actgccgcgt gattcccgcg gccattcaga agttcaagcc gagatgctga 2400 cgttgctgag caacgagatg gtgagcatca gtgcaaatgc accattcagc acatcagtca 2460 tatgcccagt gcagttacaa gatgttgttt cggcaaagca ttttgatgga atagggaact 2520 gcaaatgtat gatgattttg aaaaggctca gcaggatttg ttcttaaacc gactcagtgt 2580 gtcatccccg gttatttaga attacagtta agaaggagaa acttctataa gactgtatga 2640 acaaggtgat atcttcatag tgggctatta caggcaggaa aatgttttaa ctggtttaca 2700 aaatccatca atacttgtgt cattccctgt aaaaggcagg agacatgtga ttatgatcag 2760 gaaactgcac aaaattattg ttttcagccc ccgtgttatt gtccttttga actgtttttt 2820 ttttattaaa gccaaatttg tgttgtatat attcgtattc catgtgttag atggaagcat 2880 ttcctatcca gtgtgaataa aaagaacagt tgtagtaaat tattataaag ccgatgatat 2940 ttcatggcag gttattctac caagctgtgc ttgttggttt ttcccatgac tgtattgctt 3000 ttataaatgt acaaatagtt actgaaatga cgagaccctt gtttgcacag cattaataag 3060 aaccttgata agaaccatat tctgttgaca gccagctcac agtttcttgc ctgaagcttg 3120 gtgcaccctc cagtgagaca caagatctct cttttaccaa agttgagaac agagctggtg 3180 gattaattaa tagtcttcga tatctggcca tgggtaacct cattgtaact atcatcagaa 3240 tgggcagaga tgatcttgaa gtgtcacata cactaaagtc caaacactat gtcagatggg 3300 ggtaaaatcc attaaagaac aggaaaaaat aattataaga tgataagcaa atgtttcagc 3360 ccaatgtcaa cccagttaaa aaaaaaatta atgctgtgta aaatggttga attagtttgc 3420 aaactatata aagacatatg cagtaaaaag tctgttaatg cacatcctgt gggaatggag 3480 tgttctaacc aattgccttt tcttgttatc tgagctctcc tatattatca tactcagata 3540 accaaattaa aagaattaga atatgatttt taatacactt aacattaaac tcttctaact 3600 ttcttctttc tgtgataatt cagaagatag ttatggatct tcaatgcctc tgagtcattg 3660 ttataaaaaa tcagttatca ctataccatg ctataggaga ctgggcaaaa cctgtacaat 3720 gacaaccctg gaagttgctt tttttaaaaa aataataaat ttcttaaatc aactcttttt 3780 tctggttgtc tgtttgttat aaagtgcaac gtattcaagt cctcaatatc ctgatcataa 3840 taccatgcta taggagactg ggcaaaacct gtacaatgac aaccctggaa gttgcttttt 3900 taaaaaaaat aataaatttc ttaaatcaaa a 3931 <210> 235 <211> 1973 <212> DNA <213> Homo sapiens <400> 235 ctgatcttgg agaaataaag aatgctaatg aaaaaacaag gcttgaaaat cagaatcttt 60 taattcaagt tgaagaagta tctcaaacat gtagcaaaag tgaaatccat aatgaaaaag 120 aaaaatgttt tataaaggaa catgaaaacc taaagccact actagaacaa aaagaattac 180 gagataggag agcagagttg atactattaa aggtaccatt catttgaatt ctattgtttc 240 aaataaattc ttagttcaac tctacaatat atacgttaaa catttttaca ccttgacgtc 300 aaaagtaaat ttttaccatt taagcccaag tggcaacttt ctgaaaagtg cattagacat 360 ttccatgttg tatgtccagt ttattacatt tatttttggg gagttttaga tacttttaaa 420 atcttgagtt tatagaagat taaatgatta ggggtttaaa tgtcttgatc agaagtttat 480 tagtcactag caaaacaact aaacatggaa aaacttgagt ttcattctcg tgtgatatgc 540 ttagttattt tttgtaaaga gcacttttta agtaagagct gtggtggtat tgctaaaatt 600 ttagggtttt ctttaaaaat taaagattaa aaatcgttta atcttctcct tattacacat 660 gtatttaatg tatcaggttg tttatcttgg ccttggttac tacnnnnnnn nnnnnnnnnn 720 nnnntgccat atgcatagta aggtcagtat taattttctg gtctaacaag ggaaaatctg 780 ttgaccaaat tggtttctgt aggaattcnc tttgatagtg attttcttat gcttaacatg 840 atggccagtt cattatggaa aatgaattct gattctggtt tttgttttgt tttgtgtttt 900 tttttcccct gtaaaatcta ggattcctta gcaaaatcac cttctgtaaa aaatgatcct 960 ctgtcttcag taaaagagtt ggaagaaaaa ataggtaact atggttttgc agatgttgtc 1020 acaattaatt agacagattc ttgttagtgt tagaatagat tgggaaatat agtagccaaa 1080 taatgagttg ttaaaaacac agttcgtagc tgtcttttcc tcgagctcac attcttgccc 1140 ctctaacacc tgtttgcctt ctctttcaaa agtgttactt tctattgttt aacccaagca 1200 agattggtgt gatttataaa tggcttcatg atttattttg gatttttcat tcatttagca 1260 aattttattt aaatgcccaa ctattctaga ccctggtgat agaaaagtgg ttgaggtaca 1320 gaccatgtgc tcaaagatct cactgttgtt tgaggtgtgg acaagataca gtactaacag 1380 catgggaact taacactgtt ttgagttaaa aaaaaaaaaa aagcagcgta aaatagggtt 1440 ttcagccaag tcttgaagaa tgagaaattt tacacaggaa gaaaggtatt ctaggaagaa 1500 ggaagagcag gtgcttgtag gttgacatta tagcatacat tcaaggcacg tactaggaag 1560 ttcctggaga ggtaggagcc tgatcataaa cgcactagtt tgattgatat gcagaggagt 1620 ttaggacttt atcttatcca ttttatttcc tcacagtacc ttttatagga tagctctttt 1680 atttcccatt attagaatca ggaaacgaag acttagaagt ttgtaatgtg ccaatgatcc 1740 ctgaatttag taccctatta gattagggta agggaagttg aagagtttag aatgactccc 1800 agttgtctat aatgggtgat tggggcagat tgggatgttc agttttagaa ttaagtttaa 1860 ataccagtcc aagtaaagat gttagaatgc tatgcaaatc tggagttaag ggcagagagc 1920 taagctagag ataaatactt ctagttaaag agtggtcatt aaaagccagg aga 1973 <210> 236 <211> 2072 <212> DNA <213> Homo sapiens <400> 236 gggcagaaat accatactgt gaatggccac aactgtgaag ttagaaaagc cctgtcaaag 60 caagagatgg ctagtgcttc atccagccaa agaggtcgaa gtggttctgg aaactttggt 120 ggtggtcgtg gaggtggttt cggtgggaat gacaacttcg gtcgtggagg aaacttcagt 180 ggtcgtggtg gctttggtgg caaccatggt ggtggtggat atggtggcag tggggatggc 240 tataatggat ttggtaatga tggaagcaat tttggaggtg gtggaagcta caatgatttt 300 gggaattaca acaatcagtc ttcaaatttt ggacccatga agggaggaaa ttttggaggc 360 agaagctctg gcccctatgg cggtggaggc caatactttg caaaaccacg aaaccaaggt 420 ggctatggcg gttccagcag cagcagtagc tatggcagtg gcagaagatt ttaattagga 480 aacaaagctt agcaggagag gagagccaga gaagtgacag ggaagctaca ggttacaaca 540 gatttgtgaa ctcagccaag cacagtggtg gcagggccta gctgctacaa agaagacatg 600 ttttagacaa atactcatgt gtatgggcaa aaaactcgag gactgtattt gtgactaatt 660 gtataacagg ttattttagt ttctgttctg tggaaagtgt aaagcattcc aacaaagggt 720 tttaatgtag attttttttt ttggcacccc atgctgttga tggctaaatg taacagtctg 780 atcgtgacgc tgaataaatg tctttttttt aatgtgctgt gtaaagttag tctactctta 840 agccatctgg gtaaatttcc ccaacagtgt gaagttagaa ttccttcagg gtgatgccag 900 gttctattgg gaatttatat acaacctgct ggggtggaga agccatggtc ttcggaaacc 960 ttggtgtagt tgaactgata gttactgtgg tgacctgaag ttcaccatta aaagggatta 1020 cccaagcaaa atcatggaat ggttataaaa gtgattgtgg gcacatccta tgcaatatat 1080 ctaaatggaa taatggtacc agataaaatt atagatggga atgaagcttg tgtatccatt 1140 atcatgtgta atcaataaac gatttagata tattgcatag gatgtgccaa caatcacttt 1200 tataaccatt ccatgatttt gcttgggtaa tcccttttaa tggtgaactt caggtcacaa 1260 cagtaactat cagttcaact acaccaaggt ttccgaagac aatggcttct ccacccaagc 1320 aggttgtata taaattccaa atagaacctg gcatcaccct gaaggaattc taacttcaca 1380 ctgttgggga aatttaccaa gatggcttaa gagtagacta actttacaca gcacattaaa 1440 aaaaagacat ttattcagcg tcacgatcag actgttacat ttagcaatca acagcatggg 1500 gtgcaaaaaa aaaatctaca ttaaaaccct ttgttggaat gctttacact ttccacagaa 1560 cagaaactaa aataacctgt tatacaatta gtcacaaata cagtcctcga gttttttgcc 1620 catacacatg agtatttgtc taaaacatgt cttctttgta gcagctaggc cctgccacca 1680 ctgtgcttgg ctgagttcac aaatctgttg taacctgtag cttccctgtc acttctctgg 1740 ctctcctctc ctgctaagct ttgtttccta attaaaatct tctgccactg ccatagctac 1800 tgctgctgct ggaaccgcca tagccacctt ggtttcgtgg ttttgcaaag tattggcctc 1860 caccgccata ggggccagag cttctgcctc caaaatttcc tcccttcatg ggtccaaaat 1920 ttgaagactg attgttgtaa ttcccaaaat cattgtagct tccaccacct ccaaaattgc 1980 ttccatcatt accaaatcca ttatagccat ccccatgtgg cacattatca cagcaccacg 2040 gctgcaacaa agccaccacg accactgaag tt 2072 <210> 237 <211> 4290 <212> DNA <213> Homo sapiens <400> 237 cgcaggcgga gacagcccca agaagtcgac gcctcggtcc cgccgcccgg ccactaccca 60 gagggctgcc gccgcctctc caagttcttg tggcccccgc ggtgcggagt atggggcgct 120 gatggccatg gagggctact ggcgcttcct ggcgctgctg gggtcggcac tgctcgtcgg 180 cttcctgtcg gtgatcttcg ccctcgtctg ggtcctccac taccgagagg ggcttggctg 240 ggatgggagc gcactagagt ttaactggca cccagtgctc atggtcaccg gcttcgtctt 300 catccagggc atcgccatca tcgtctacag actgccgtgg acctggaaat gcagcaagct 360 cctgatgaaa tccatccatg cagggttaaa tgcagttgct gccattcttg caattatctc 420 tgtggtggcc gtgtttgaga accacaatgt taacaatata gccaatatgt acagtctgca 480 cagctgggtt ggactgatag ctgtcatatg ctatttgtta cagcttcttt caggtttttc 540 agtctttctg cttccatggg ctccgctttc tctccgagca tttctcatgc ccatacatgt 600 ttattctgga attgtcatct ttggaacagt gattgcaaca gcacttatgg gattgacaga 660 gaaactgatt ttttccctga gagatcctgc atacagtaca ttcccgccag aaggtgtttt 720 cgtaaatacg cttggccttc tgatcctggt gttcggggcc ctcatttttt ggatagtcac 780 cagaccgcaa tggaaacgtc ctaaggagcc aaattctacc attcttcatc caaatggagg 840 cactgaacag ggagcaagag gttccatgcc agcctactct ggcaacaaca tggacaaatc 900 agattcagag ttaaacaatg aagtagcagc aaggaaaaga aacttagctc tggatgaggc 960 tgggcagaga tctaccatgt aaaatgttgt agagatagag ccatataacg tcacgtttca 1020 aaactagctc tacagttttg cttctcctat tagccatatg ataattgggc tatgtagtat 1080 caatatttac tttaatcaca aaggatggtt tcttgaaata atttgtattg attgaggcct 1140 atgaactgac ctgaattgga aaggatgtga ttaatataaa taatagcaga tataaattgt 1200 ggttatgtta cctttatctt gttgaggacc acaacattag cacggtgcct tgtgcagaat 1260 agatactcaa tatgtgaata tgtgtctact agtagttaat tggataaact ggcagcatcc 1320 ctggcctgtt gtcatgcagt catttcctgt taattctggg agacaatgat ttcacaacta 1380 gagggaagca gtcctaaaag tttaaaatcc gataaggaat atctgggaca gggtttagat 1440 catgactcta cacagatacc atgatgagag tatattaaag aaatttagga aagcacctgg 1500 ttcctttctc cccatgcctg ccttctgctc cctccccagc tggtttgggc tcaaattgtc 1560 cctggagact agggtttatg ttagggtatt gatagattag agcaggtggt tgaagagatc 1620 ttctctggtc agacttggaa gaatttccaa aagtgaagtt agccccaaga cttccctagg 1680 gttgatgtac tttatgatcc agatgctaaa cttcttagaa tgaaaatatg cttcaacact 1740 taagtagcat acactgccct acaaacctca gagagcactt ttccccaagt tcttgttttt 1800 atttttgaaa gtactcacac agcacttact atgctccaaa cactcctcta agcactttac 1860 acatattagc tcattcagtc cccagacaga cgggatgaag taggtattgt tactgttccc 1920 attttacagg tgagagattt gaagcctggg gaggctagta actcacccca aggtcacacg 1980 ggctcataca tggtgggact gagactcaga tgcaggcagt ctggcacctc agtctggatt 2040 ctaaccattt cactaagcta tttttgtctt gtactacttt gacccacccc tgaataaacc 2100 tcaattgctg gagtggggtg tagttattaa agggatgctt tttacctttt gctgtttgct 2160 gtggcagatt ccccagataa ccaaggaaaa ggggccaccc atacctggaa ataggccata 2220 gggcccctac tactgccaac aagccatggc ctaccttgac acttgtttga tcttaaaatt 2280 gtgtcttggt aacaaaagat ttggacaggc atatctgtag ctttcaagtt aattaattgc 2340 aatatttttt tcttcaggat tttagctgct gaacaacttt cagtttggag ctaaaagaga 2400 cctgtctcat ggtctgccct tccctggggc aatagctagg gtctttcctg atttttatgg 2460 aattttaggg gatattttga gctttgggtt ctcagtagtg aattgagact tggaggtgac 2520 ttttcatgtt tggagtatca tctctgtctg ggctctgggc tgacaaatta aaacctagag 2580 tagtgcttat gctgaaatga tacttttcat tttttggttg atttttttgc cttcccttca 2640 attttaaact gaagcatttt aatgtgggta gaaactctac accaaataca ctaaacattt 2700 tggtgcttag tggatttctt tttaggtaac tggtacttac ttccaaagac tgaatacaag 2760 ccacactcca tcatatccct taaacttcat gaaaaaccat tcaagatccc cttgctgcaa 2820 cactgttctc ttcttctcta ctaaattcta tttccaaaat tggtaataga gccagaagga 2880 tccccagtac ccagccctct gcctggcaca aactggtagc acaattaaat tcagtatggg 2940 tggagcatgg tacagtcttg gtgccataga aggagtagtt gcatagtcac acatcatttg 3000 ataagttgga tgttccatta catagaggaa cacaaaattc cagggttttt ggaggaaggg 3060 attagatagt gactaagccg ccagaattga ggtggccatt cctttttgta taggctaaga 3120 aacaggttat cagtgaaaag ttaattatgg ctttggcact agaatagcac tgttgcaaag 3180 tatttaagca ccccccatct cagcccttta ttttatcttt catgtgggct aatgtgagga 3240 taatcttaca gatattatag gaatttcttt tctatcttta tgaaaacaac gtatataaaa 3300 tatatctaga aaacctttgt ttgagactct tatttaatgg gcttttgatt ctaatgataa 3360 ttgtaccttt atctttcaaa agctgatatt tcctacctaa gcatctcccg agaaaaatat 3420 ctcattaaaa agcccataaa taatagggga gaagaaagcc ttaggtatca attccaaaac 3480 agtgattgaa atttcccaaa ataattatgg cttctgtcat ctccagagat aatctggctt 3540 ggtttacccc ataatctaat ttcagaaaag aaagctttat tttaacactc atctgaatca 3600 acattaaagc cttttctctc aaagcgttta ttgagaaact caaatgaata tactttttga 3660 attactgtca tcaaaagtgt acggcttcct gtgctgcttg tgtcaaatgg aacctgccct 3720 ctaaagcact ttctttcctt tacttgcgtg gtttcatgta agctgtgctg tttagaaaca 3780 acatctcaga ctttacaaag aaatgacaaa gaaggcaatt gcacttttta agggatatcg 3840 acaagcagtt tctgttttct aaaggacaaa atacagagtg tgtgtcattt ttaattagat 3900 tctttcccct gctgagttgg aaattccagt gcagcactga ttgaccacag ttgccaatct 3960 aaaagcacaa agacagaagt aaagctttat gctaatttta tttcaatatg atagaaaatt 4020 tatcttggta tgtccttttt tagataactc cagcaggaaa ctgtaactgc tatgtcttta 4080 ggaaaatgta gaagaaagaa cattattatt ctttaattcc tacaaggtac tcgaaaacct 4140 taagtgaaaa agatttctat ctttttatct tagcgcattt atggaaaaaa tattaactat 4200 cctgaatatt ttataatttt gtaggaaaaa tatgcatcta ttttttcttg acttctttta 4260 tatagtaata aaagttattt tggaaaaaaa 4290 <210> 238 <211> 3807 <212> DNA <213> Homo sapiens <400> 238 gcatccttga agtccaaaaa ttaatcaacc tttggtactt gttgttaatg tccagtaagt 60 agtatttata gaaaagatga atattattaa tcataaacag tgaaacatac tttgcgttta 120 cacttagcct attggtgtgg ctataaatct tatttatttt agttgtgctc tatttcttat 180 tgatctttac aatgtgttct ctaaagtaat aaagtgaatg caaatatacg tggtcacagg 240 tttattctga gttttaattt attatacaaa agtaaaggtt ttaatttaat attaatagta 300 gaaaaacact ttcttacgtg tgccatatgg aaagataaag gatctattct aaaattagct 360 gtgttggttg ataagctggt gtggattctg ccacatccag caaggaagat accattaaat 420 tacacagttt agctctctct atctatgcat taggaatttg acttccattt gatgttaaag 480 catatacttg gctttaagga cacactaaaa ctattcaaag tttaattaca ttcagacaaa 540 gatcatctaa ccactgttgc tacataggga atatttattt aattatccct tgctatctct 600 attaatcagt ttcctcaatt tatccttaaa attttcctca aatgcttagt tattttatta 660 tttgcttttt aaaatattca gtgtcaaaac aaaagtacac agtttaaata attaagcagg 720 catacttctc cctgtctcac ctgcttgatt ctaaattgca aggtctacca tgtcaaattt 780 tagataatca gaacaacact ttgggattaa ataccaactg acttcatttt tactccataa 840 gccttctcat tgctactttg catttttctt cactaaccta tctgtttgtt agtaagtttt 900 tcagttcctt cttcatcttt tctttccctt gtagctgtga gcactccagt agattgcatc 960 actaggttgg gtcctgtgag ctgttttgtt cttttccaag tgtctgattc agcgggccat 1020 agaccgcttg ccagaaaatc gccattgctt ctaggctgac gcttgcctac ttgttttgat 1080 cgtctgagag aagagacttt gtttgccaaa accacagttg atagaaatag aaaggtacag 1140 ataagaaaaa gcactgcaat tataattaag caaattagca tagccatgtt gttgttgttt 1200 tccgcacaga catccttttt gaaaatttca ccatgacttt tgcttgtgtt ttcaatgctc 1260 tgtactgttg aaggactgtt gctgacgaca gaaggtatat aaagctcctg ttcagattta 1320 gaagttaaag ctacgatgtg agatgtttca ggcatgtttg tagaattacc tttataatct 1380 acttcaggag ttatagggtt tgtgttaatg ttttcatttt ggtttctgcc tgtcttgttt 1440 tgaataactg aatcccagga agaagtactg ttagcccaca gacgggtata gtttgctttt 1500 gttccaggag acaaagaaaa aactgttgtc atcagaaagg caagatgtag gtaatgtcct 1560 gtgtgttcca tgtccgtggg catacttggc aatcttacaa aatgcttggt caaaatctga 1620 ttataacgtg attttgataa accacttctt ttcttgtctt ctttttaaag cagaatagac 1680 ttggagaata tgagccttaa agtaaatgct ccagtttgct gcctgggtgg atgcagtggt 1740 gtttgtgttc agcctggagg atgaaatcag tttccagacg gtgtacaact acttcctgcg 1800 tctctgcagc ttccgcaacg ccagcgaggt gcccatggtg cttgtgggca cgcaggatgc 1860 catcagcgct gcgaatcccc gggttatcga cgacagcaga gcccgcaagc tctccacaga 1920 tctgaagcgg tgcacctact atgagacgtg cgcgacctac gggctcaatg tggagcgtgt 1980 cttccaggac gtggcccaga aggtagtggc cttgcgaaag aagcagcaac tggccatcgg 2040 gccctgcaag tcactgccca actcgcccag ccactcggcc gtgtccgccg cctccatccc 2100 ggccgtgcac atcaaccagg ccacgaatgg cggcggcagc gccttcagcg actactcgtc 2160 ctcagtcccc tccaccccca gcatcagcca gcgggagctg cgcatcgaga ccatcgctgc 2220 ctcctccacc cccacaccca tccgaaagca gtccaagcgg cgctccaaca tcttcacgtc 2280 tcggaagggt gctgacctgg accgggagaa gaaggctgcc gagtgcaagg tggacagcat 2340 cgggagcggc cgcgccatcc ccatcaagca ggggatcctg ctaaagcgga gcggcaagtc 2400 cctgaacaag gagtggaaga agaagtatgt gacgctctgt gacaacgggc tgctcaccta 2460 tcaccccagc ctgcatgatt acatgcagaa catccacggc aaggagattg acctgctgcg 2520 gacaacggtg aaagtgccag ggaagcgcct gccccgagcc acacctgcca cagccccggg 2580 caccagcccc cgtgccaacg ggctgtccgt ggagcggagt aacacacagc tgggtggggg 2640 cacaggtgcc ccccactcgg ccagcagcgc atccctgcac tctgagcgcc ccctcagcag 2700 ctcggcctgg gctggcccgc gccctgaggg gctgcaccag cgctcctgct ccgtttccag 2760 ctgctccggg ccgtggtgga agatgacctg cggctgttgg tgatgctcct ggcacatggc 2820 tccaaagagg aggtgaatga gacctatggg gacggggacg ggcggacggc tctacatctc 2880 tccagtgcca tggccaacgt tgtcttcacg cagctgctca tctgggtgag tcacgtgcct 2940 ctagcctgcc ctgacctcgc tcttcttagc cttgttcttt gaaagcaacc tcttctttcc 3000 tcccctacaa ccaatctctc tcctcccatg tcttgccaac tgtcaacatg tgttttctcc 3060 tacagtacgg ggtggacgtg aggagccggg acgcccgggg cctgactcga ctggcatatg 3120 ctcgccgggc cggcagccag gagtgtgcag acatcttgat ccagcatggc tgccctgggg 3180 agggctgtgg cttagcgcct acccccaaca gagagcctgc caatggcacc aacccctctg 3240 ctgagctgca ccgtagtcct agcctcctat aaggcccagg aagagggcag aggggccaga 3300 aggactccat ggcccaaaga ccctcctccc tgcaggcact gtgggaacag acacagagat 3360 ggagaagcag ggacatgctg agaggacgaa gccaaggaaa ttagggagga gagtcaaagg 3420 gatcaaggag agttggggat ttgagctgca gcagagaggg atgagggatt tagccctctg 3480 ccctaaggtg ccattgaaaa gggacaggac ccttcggagg tgcctgtgag gagaggggag 3540 caggacctct ccctcctcca gatccctgcc tcctagtgcc agcccctcac acgccttcat 3600 cctgaaacag gaagaggacg gcaccaagtt gggggtgctg gatgaaagag acgaggggtg 3660 atctgtgagt cccatgtaaa ctttgtacat tggaatattt atgtttgtgt acatatttga 3720 tgtgtgtgtg tatgatgagc caataaacca gactgtgtgc gtttaaaaaa aatctatgtc 3780 gggtgcggag aaagaggtaa tgaaatg 3807 <210> 239 <211> 913 <212> DNA <213> Homo sapiens <400> 239 gcggtgaggg tgggtttata aaagggtcag tatatattga gaggaggnga ganagagaaa 60 cgggagccag agagaaggag gcccagacag tgagggcagg agggagagaa gagacgcaga 120 aggagagcga gcgagagaga aagggttctg gattggaggg gagagcaagg gagggaggaa 180 ggcggtgaga gaggcggggg cctcgggagg gtgaaaggag ggaggagaag ggcggggcac 240 ggaggcccga gcgagggaca agactccgac tccagctctg acttttttcg cggctctcgg 300 cttccactgc agccatgtca ctcctcttgc tggtggtctc agcccttcac atcctcattc 360 ttatactgct tttcgtggcc actttggaca agtcctggtg gactctccct gggaaagagt 420 ccctgaatct ctggtacgac tgcacgtgga acaacgacac caaaacatgg gcctgcagta 480 atgtcagcga gaatggctgg ctgaaggcgg tgcaggtcct catggtgctc tccctcattc 540 tctgctgtct ctccttcatc ctgttcatgt tccagctcta caccatgcga cgaggaggtc 600 tcttctatgc caccggcctc tgccagcttt gcaccagcgt ggcggtgttt actggcgcct 660 tgatctatgc cattcacgcc gaggagatcc tggagaagca cccgcgaggg ggcagcttcg 720 gatactgctt cgccctggcc tgggtggcct tccccctcgc cctggtcagc ggcatcatct 780 acatccacct acggaagcgg gagtgagcgc cccgcctcgc tcggctgccc ccgccccttc 840 ccggcccccc tcgccgcgcg tcctccaaaa aataaaactt taacggcggg ctctgccttg 900 atcttccttc aaa 913 <210> 240 <211> 4363 <212> DNA <213> Homo sapiens <400> 240 tgctgattta gtaccatcca ttgctgcaac accagattac gacaatactg catgatttaa 60 cacacaacca cacacacaaa gcacacgcgc acacgcacat acatgtacaa agggatattt 120 tggtggtggt ggattttttt ttgtcttttg tcttcctatt cacattacaa aaggaaaggg 180 caaggttctg cagaactgac gaaggaacta acagatacta caaaaatatt acaatttgtg 240 aagattagct caaccctctc agcttttatg aatggagcgg ggaggggccc aggctgagtg 300 ggaagggcat gggagtgagg gggccagcta gttctatgga atagtttgat ttttttctct 360 tccttcccca ccaatgttga atgacatctt gctgttaaaa atactgtttt ctgggattta 420 cagatcccct gagggccagc caggaaagaa gagttggagt gagatgaagg aaggactatg 480 acaaatnnnn nnnnnnnnnn nnnnnnnnnn nngaaggaaa aggaaacctg gtagcttttt 540 ggccttggat tctctctggg ctccagatga cctggatgcc aagccactgc ccctcctctg 600 ggggcctcca ccctcctctc ccggctggag gtttgcctga ttttctggga tggggttggg 660 tattttgttc actcaaatgg tggcacattt ttctccttcc ttcacccaga ccttctttta 720 tgtgtccaga aatggaggct agaaagcagg tgagaggtcc tctggtcaga gccacacggt 780 ctgtgccggc cttcctccac caagaccccc aggagatgaa gggagggagg aggtgagcca 840 gaagggcgct cccctgctga tgggtctggg ctgggtcact agctgctcaa aatggcagct 900 ctagtttgct ggcggctgac tggggaggag aagggctctg tttctcttcc caccactcag 960 cccacctgct gctttcctct gctttgccac atctgggtgt cccccggtgg tctctgagag 1020 cctcaggacc cctgcccctc ctccagctct ttgttcccag cctccccttg actcctgtcc 1080 tccaagtccc aggggagtcc cagcccctca gggacctggc ggtgtctcca tccttctccg 1140 gttccctagt gggatagctg cctctgactt cagggtccct cctaccctca gccttctgag 1200 aacacaaaac aaatccaata ccccacccta gtccagcacc atcgtgagca agattcctgc 1260 tgcgctgctt ccaaaatgga aaagcatcac aactaaatac ctaatatcct accaaacaaa 1320 ccacagtccc tacgtagccc tacttcagtc ccaggagaag gaatccatga atgggctgag 1380 gttccgaggg taggttgtgg atgtctttct ctagaggggt cccacacctg gaaaagagga 1440 cacccagccc gtgggatgag ggaagctggg caagggagaa agttgttgag tcacactggg 1500 gaccccagat gtagtgagct cagcaagaaa agccaggtcc agagagagtc gcacagaatt 1560 cctgactcac agcgcccctc ggtccacagt ggannnnnnn nnnnnnnnnn nnnnnnnnnn 1620 nnnnaggact gcaggaggag gaggatctga aagcgctttg gccttgtgtt atgttttgct 1680 tcttttctgt gtcccctgtt agcacattgt acttgaatta cctcagtttt ttgtgacctc 1740 atgagctttc ttaacctctg tatctctttt tcggttgggg cttggaggaa tggggagggt 1800 gttcttttct gtttcttgtg taaattaata gttgttttta tagacttcag ctggtcaaga 1860 ccctccccgt gcccctggag accagcctcc cagctggcag gaactgtgca ggaggagttg 1920 atactcagga tctgaatgtg agggccgagg agggcgaaga gcgtgggtgg ggaggggatg 1980 ttgctttggg gtctcatggt ccccagaggg cactagggag tcacttttgg ctccgctggt 2040 gcatgaagtc acctgtggcc accatccgtt ccgcctaaaa cactctggag agaatcccac 2100 ctttcttaca atttgctggg ccattgaggt ttgagggcct gtgtttggat ccttgcaact 2160 gtgtggtctc acctctgtgc gtgcattctc attgccagaa ttggtctatt ttcacggctg 2220 gtctttgggg aggggggcgg gatccagcct ttgttttgtt gtgttggggt gggggtgttg 2280 tttttctaaa agctacctct tatgtttgtc cagttgttct tttgttcctt tcccgcctcc 2340 cattctgctg ctcttcctcc ctcttttccc caacctcccc cgaccctcct gaattttgga 2400 aagcacattt gcaatattcg tgtttgcttt gggacggacc ctccgtttca tctcatgctt 2460 tatgtgtaag agttttttat tattattttt tctttccttt ctctctctga gaaagttgtg 2520 gctgcgtttt gatcttaggt tttacaaagt ggtttaggga agcggttttg gggagaagga 2580 tcacgaggaa tgtagggaag ccggagggat gggtgctgct gcgacgaccc ccccgtccct 2640 cggccccagc cctcctgccc tccccttcaa tctcatccac caaatctgaa ggccttaaaa 2700 ttgtgtgttg ggaggatgtg aattgggagg acggtgtcac tagactgtgg attagggatg 2760 gtaaagtagg gaggatgcta ttttgcaact atagtaacga cttagtgttt tggaaaggaa 2820 aagaagttaa acttgaaata cgtgactaga acagttgtca tgtttataat gtgaaaaggg 2880 tgaaatcatt tgggggaggg gccgtctgta agaaatcatt atgcactatg gcttcctcct 2940 ctggtctggg aagaagcggg gactggctgg ccctcagggg atctgtaaat cccagaaaac 3000 agtattttta acagcaagat gtcattcaac attggtgggg aaggaagaga aaaaaatcaa 3060 actattccat agaactagct ggccccctca ctcccatgcc cttcccactc agcctgggcc 3120 cctccccgct ccattcataa aagctgagag ggttgagcta atcttcacaa attgtaatat 3180 ttttgtagta tctgttagtt ccttcgtcag ttctgcagaa ccttgccctt tccttttgta 3240 atgtgaatag gaagacaaaa gacaaaaaaa aaatccacca ccaccaaaat atccctttgt 3300 acatgtatgt gcgtgtgcgc gtgtgctttg tgtgtgtggt tgtgtgttaa atcatgcagt 3360 attgtcgtaa tctggtgttg cagcaatgga tggtactaaa tcagcacctg gatgccccac 3420 ccaaccccgt gggccctgca gaccccagta gggaggtatg gggagagctc aggggagtgt 3480 ggtttctgag ggctactgtc tggggacacc tctgaactta ctgtaccttc ctctccccat 3540 gaagacacct gaatagagtc taacatgcct cttctccaac ttcctaccta caacaacaga 3600 acagttctaa tgttgcacgg cctagtggcc agggggcaag ctaagaggct gtctggaggc 3660 tttatatgtg tctggagtta aggggagagg aggagggtag acaggggtct ctccccaggt 3720 gggatctgaa tatctgtcct cccctcttct tcatgccacc tgactccttc ggccccctgg 3780 ctgcctttag ctgtggtact gctgacaacc ctgcttgcta ctgccttatc cagcacagtg 3840 aaaaacttct ccagcctggc aaggccacgt tggttaatag tccctttccc atgtccagct 3900 cctacaaata tgtcccttaa tgcatttggt gacatttaca cctcactcat gtgctctttc 3960 cctattcact ccttcactca ttcaaagcat taaaatccta tgtatatata ggatagacaa 4020 atatatagat atatagatat atatatatat agcaagagat tgatataaaa tagtaaatat 4080 cattgctgct ttgggctgct ttggaggagg aggccatgaa tatggggaag gcagatctgg 4140 ggtgcagggg taggtaggga ggctggggga cccagtgatt cagtacaatc caagggatgc 4200 aacgcgggct tgtttaatct ttgtgcctga acagtttttc catgttgaga aaaaaaagaa 4260 aaaaaaactg ctgcaatttt tcacaagtgt atggtacctt tctggatgct attggtacaa 4320 ttgctgtgga tggaagaggg ccattgagct tacctccagc cgg 4363 <210> 241 <211> 1883 <212> DNA <213> Homo sapiens <400> 241 atacttggaa ctgctatacc tttgcttctt taaaacttgc tccacacagt gtagtcaagc 60 cgactctcca tacctgtaga aatttaatct cctttaccaa taggtagtaa taggtggatt 120 tctaaaagat ttcccaacta ctgtttcagt ttaagattaa tctccatttt ctttctcaga 180 gagattccca tctgctttaa ttttaaaatc atcactaaca gtagctcaat caattaacgt 240 taacatcaat aaaacatgta cctttaaaag gtatgacagg aactgtcttc atgtccttac 300 ccaagcaagt catccatgga taaaaacgtt accaggagct ggaatacaaa tgaggacttc 360 cattaaaatg ctaaacatca ttaaactctt ttcaaagttg tctgtcacag ggttcttcag 420 tgttaccttt gtctacatgc tcatttcagg tcagacattt gatcaacatc attacacaaa 480 ccccgttcca aacatgctca aggaaaacac ataaacactg ttccagacat gctcaaggaa 540 aatacagtca gtattcatca gccaagcctt aagccattag ctcagcagta agcatatcac 600 catcagcatt ttcattaagt ctatctactg ttttcattaa tacttaccag aaccattaag 660 ctggtccagg caagttggac tccacctaag aaataagagt ggtcttagaa tagccacaga 720 tgagtgttca ccccctgcca aaactaacaa atgcctttag tcagttagag ctaattaaga 780 ccttcatgtt cagtcagcat ttgcttatca tcatccaggc tgcatttaca aactttctta 840 ttaatcataa caagacaaga atccgccatt tatttaatgc attcagcact gggaggtaac 900 taaaaagcca tttgtgccgt aggaagtttg ccccagttac ctgcttgctt ggatacagtt 960 tcacttaccc tttcaacttc cagctttctg tctaatgcct gtgtgccaat ggcttgagtt 1020 aggcttgctc tttaggacct gggaagaaac aacttcatgt gaacttaggt gtactctcta 1080 tgttccccaa ctcaccattt tgggtgcctc agttaagata atggtggtta agatcctcat 1140 cattctagca ctcaagagta gcaaataaac tgtcatcatt gtggcacatc caatggcttt 1200 aaaccttttt gagagggaat tttcaactta cttcagtagc tattctcatc cttccttggg 1260 gacacaactg tccataaggt gctatccaga gccacactgc atctgcaccc agcaccatac 1320 ctcacaggag tcgacgagaa tagctactga agtcctaaag agcaagccta actcaagcca 1380 ttggcacaca ggcattagac agaaagctgg aagttgaaat ggtggagtcc aacttgcctg 1440 gaccagctta atggttctgc tcctggtaac gtttttatcc atggatgact tgcttgggta 1500 aggacatgaa gacagttcct gtcatacctt ttaaaggtat ggagagtcgg cttgactaca 1560 ctgtgtggag caagttttaa agaagcaaag gactcagaat tcatgattga agaaatgcag 1620 gcagacctgt tatcctaaac tagggttttt aatgaccaca acaagcaagc atgcagctta 1680 ctgcttgaaa gggtcttgcc tcacccaagc tagagtgcag tggcctttga agcttactac 1740 agcctcaaac ttctggggct caagtgatcc tcagcctccc agtggtcttt gtagactgcc 1800 tgatggagtc tcatggcaca agaagattaa aacagtgtct ccaattttaa taaatttttg 1860 caatccaaaa aaaaaaaaaa ggg 1883 <210> 242 <211> 641 <212> DNA <213> Homo sapiens <400> 242 ctctggccaa acgcttgacc taccttgcct ctgttcccac aacaatactg caaggctcac 60 ctgaagtgtg aagaggggga gtgccactct ccatccaggc cccaggcaag cagcacctcc 120 ctgctctcct gcactcctgg acacaaccag cagctcctgc catggacagg tggtacctgg 180 gcggcagccc caagggggac gtggacccgt tctactatga ctatgagacc gttcgcaatg 240 ggggcctgat cttcgctgga ctggccttca tcgtggggct cctcatcctc ctcagcagaa 300 gattccgctg tgggggcaat aagaagcgca ggcaaatcaa tgaagatgag ccgtaacagc 360 agcctcggcg gtgccaccca ctgcactggg gccagctggg aagccaagca tggccctgcc 420 tctggcgcct ccccttcttc cctgggcttt agacctttgt ccccgtcact gccagcgctt 480 gggctgaagg aagctccaga ctcaatgtga cccccaggtg gcatcgccaa ctcctgcctc 540 gtgccacctc atgcttataa taaagccggc gtcagagacc gctgcttccc tcacctgcct 600 gcctgtctcc ctcctctgtc accaccagcc tctccaagct c 641 <210> 243 <211> 976 <212> DNA <213> Homo sapiens <400> 243 tctacatcta tcggagctga acttcctaaa agacaaagtg tttatctttc aagattcatt 60 ctccctgaat cttaccaaca aaacactcct gaggagaaag aaagagaggg agggagagaa 120 aaagagagag agagaaacaa aaaaccaaag agagagaaaa aatgaattca tctaaatcat 180 ctgaaacaca atgcacagag agaggatgct tctcttccca aatgttctta tggactgttg 240 ctgggatccc catcctattt ctcagtgcct gtttcatcac cagatgtgtt gtgacatttc 300 gcatctttca aacctgtgat gagaaaaagt ttcagctacc tgagaatttc acagagctct 360 cctgctacaa ttatggatca ggttcagtca agaattgttg tccattgaac tgggaatatt 420 ttcaatccag ctgctacttc ttttctactg acaccatttc ctgggcgtta agtttaaaga 480 actgctcagc catgggggct cacctggtgg ttatcaactc acaggaggag caggaattcc 540 tttcctacaa gaaacctaaa atgagagagt tttttattgg actgtcagac caggttgtcg 600 agggtcagtg gcaatgggtg gacggcacac ctttgacaaa gtctctgagc ttctgggatg 660 taggggagcc caacaacata gctaccctgg aggactgtgc caccatgaga gactcttcaa 720 acccaaggca aaattggaat gatgtaacct gtttcctcaa ttattttcgg atttgtgaaa 780 tggtaggaat aaatcctttg aacaaaggaa aatctcttta agaacagaag gcacaactca 840 aatgtgtaaa gaaggaagag caagaacatg gccacaccca ccgccccaca cgagaaattt 900 gtgcgctgaa cttcaaagga cttcataagt atttgttact ctgatataaa taaaaataag 960 tagttttaaa tgttat 976 <210> 244 <211> 5886 <212> DNA <213> Homo sapiens <400> 244 ggggggagcg ctcatagcta ccaacacaac agaaaatagc accagagagg aagttaatga 60 gagacagtcc catccagcta cgcagcagca gctgggcaaa accttgcaaa gtaagcagct 120 cccccaggtc ccaaggcccc ttcagctctt ttcagctaag gagctgaggg actccagcat 180 tgacacacac caataccacg aaggactaag taaagcaacc caagatcaga tccttcagac 240 tctcattcag agggttcgga ggcagaatct tctctcagtt gtgccgccct cacagttcaa 300 cttcgctcac tcaggtttcc agctggaaga catctccaca agccagaggt tcatgctggg 360 ttttgctggc agaaggacat ccaaacctgc aatggcaggg cactacttac tgaatatttc 420 tacctacggc cggggctcag agagctttag gaggacccat tctgtaaacc ctgaagatcg 480 tttttgtcta agcagcccca ctgaagcctt gaaaatggga tatacagact gtaaaaatgc 540 aacaggagag agtagcagca gcaaagaaga tgacactgat gaggaaagta ctggtgatga 600 gcaggaatct gtcacagtga aagaggagcc ccaggtttcc cagagtgctg gcaagggtga 660 cacaagttca ggacctcaca gcagggaaac tctatctacc agtgattgct tagctagcaa 720 gaatgtgaag gctgagatac cattgaatga gcaaaccact ttaagtaagg agaattacct 780 gttcactaga ggccaaacat ttgatgaaaa gaccctagcc agagatttaa ttcaggcagc 840 acagaagcag atggctcatg cagtgagagg taaggcaatc cgtagcagcc ccgagctttt 900 cagttctact gttcttcctc tgcctgcaga cagccccacc caccagcccc tactccttcc 960 acccctgcaa accccgaagt tgtatggaag ccccacccag atagggccaa gctatagagg 1020 catgatcaat gtctccacct catctgacat ggaccataac tctgctgtac caggtagcca 1080 ggtatctagc aatgtaggtg atgtcatgtc attttcagtg actgtcacta ccatccctgc 1140 tagccaagct atgaatccca gcagccatgg ccagaccatt cctgttcagg cgttctccga 1200 agagaacagc atagagggca cgccttcgaa atgttactgc cgcttgaaag ccatgatcat 1260 gtgcaaaggc tgtggcgctt tctgccatga tgattgcatc ggcccctcca aactgtgcgt 1320 ctcctgcctt gtcgttcggt aatgagacta gaaagagata cactgtaaag gagggggaag 1380 ggaagggttg accagttggg ttttttgcgt ccttttggaa tcacagaaat aaacaagtag 1440 gtttcagttg tcttcagaga caaatgttac ttaatcagga atacaaagta cagatttttt 1500 acattttaga ggaagagcac cttgtatagt aagtctaagt caagcaagac tttgtgaatt 1560 tgtgacaagt ttgcacttac aaaatcatgt aaatatgtca cattttgttt aacattattt 1620 ttccaagtgt ttaggtaata atgtattact ttgaattcag attaatgttc tactacttgt 1680 gactgagaaa agtttaatgc cggcatggta aaaggaagct gtctcccttc tgacatttcc 1740 taggaagcta ggaaaaggaa agtgaaggaa tggtctaaag aaatgaccat tcacactgat 1800 tttgtctgga cagtctggcc gcagttattc atagattatt cagcctttgc aggacttgga 1860 ttcagggttt tactcagtcc ctttacctta ggtggaatct tcttaaattg aaatttttgg 1920 taaggaattc atttcacagg tagtgtttca gactctgaaa gccctgactt ggttcttggc 1980 ttctactgta ctagttacta gttactggta ctgttgccaa gcaatctgct tggaatttgt 2040 ggatccctgc tgttccctaa tcccaccccc tgccctgaga cagtgaatgt agtccgtgaa 2100 gggagtgcct ctctgggacc ccctgtgttg ttacaggctg tgcagtgcaa caattccagc 2160 aaaaataccc tatccccgca cttagtcatt cgtggtaact aacaattttg aaatactcat 2220 ataaaatgaa caggaaagtg ttagtgattg ggtgatttga gctacatctt gttgagcaag 2280 gggagtgaaa ccacagaaac tgttaaattg aacgtaaata actttggaaa acagttttga 2340 cactagaaca aggtcgcttc tcttttcctc ttctctccca acctgttaac ctagtgctag 2400 atagtcagct gctgttgcag gtagaaaagc tcaccaatgc cacatttgtt cattctgttc 2460 aacctgtttt gacctcccag gcatctgaac aggatgacat catcttatta tatcttactt 2520 tacacatacg tgtatgtaca cacacacaca caatacaaga catttttcct gttttagaaa 2580 atatagccct tgtttggatt actgctgtct gagcactaga aatttctaat ggaaagaggc 2640 ctctgaatgg ctaagggaac atctggaaag gaaggaaaat gagccctaaa ggttttttgg 2700 ttgcttgttt ttgtttcttt ttctttcttg tttccttttt tgtttttaaa tccttctcta 2760 gtgactgaag aaattgtgag tacataatat ttaggtcatg gttaaggaac attaaaataa 2820 acctgcagtt taacagaatt ttgtattaaa tgggggagtg tcaatttgca tcatttgcat 2880 attgatttca agtctcctaa tttggaatgg gtaaagtaca aatgttaatg caacatagta 2940 cagttgtatt tgtccttcat attcaggatg tgatatttac aaaatgcaga acagtttaaa 3000 cttgttaagt cacattccag attaggagaa aatgggcaat aatcatctct gttttgcccc 3060 cattctacta cccaccactg cccaccccac ccccacatca cacactcttc gatgctttcc 3120 cacagcccct gctccgctcc tctccgtaag aaactcactt cactgttttt cacttttcac 3180 ttctggcttt tttgtggccc aaggccaata taggattaat atctgtgttc cagcttcagc 3240 cagaacgata tgtctgtcca tctttctcct ttcttccagc acacacagct aagagataag 3300 aaggctgcaa ggattgggga taaggagtat attttcaagc caagaaccag tagaaaacag 3360 aaataatggt gctcccaaat attcagtacc ttgggcaatc caggaagggt ttaaagagac 3420 ctgttgctgc atagaactct ccctgcccta ccccttaact ccaccttagt gccagggccg 3480 agggctggtc tgcatgctgg aagaggttga gagttttgga attgattcca tgctaaatgt 3540 cagttaccag tttggattga tgaaagtgat ttttctgctt tacctttttc ctgtcagaaa 3600 ggttttcctc tgtgctaccc ttaacttagg gatgaacaga ctataactag gaaaggagga 3660 aaggtatcag ggatttttaa gtccgtttag agagcaaacc atattgtgcc tcttcatctt 3720 gacccaggct cttatagata ggtcctaaac attgctgttc actagattat cttaacaaat 3780 aatactcagc taaatatttg catttaggaa tactcctaaa acagatattg ccaactagat 3840 acactgcctc aatcttgacc agacaagaga acagttaagt tctctcagtt gggtagtaac 3900 ttgaatacca gtctatttat cagttggttt caacacagag gtttcaagtg gaaagccatt 3960 catcttaaaa gctgnnnnnn nnnnnnnnnn nnnnnnnnnn nnctttacaa tctggccttt 4020 tagaaaatga agcagtagaa acaaaacctt tattagtatg gtattccagc agcaccttta 4080 aagcaatctt taccttagtt ttttgagttg ttttaccttt catcccaatc tgaaaagttt 4140 taataaatgc tgagcttatt cttagggtat gacctggcat tatttccagt gactagtcag 4200 gcattatgcc tgatgcatac gcctcccgtg cacccctatc tagccttcag atgtcctcca 4260 ctgcaggtca ccccaggaga tagcatcaat aatatagtct cagtcttgtt tataaagatt 4320 ctaagttgtc tagtaaataa gtctccctga atcttaaata attttggaga attagaattc 4380 tccatcctat taaacagaaa gtaaagccaa atagcctgga gttgtttgtc ctacttgttc 4440 cataacccct atgctcaaga tactgaagct atctgtggta tttcatgtaa catttctaag 4500 aataagagct ggcaaatggg aaacttgggg tggagagagc atacttattg ggctgtgaag 4560 gcatacggat gtacatgttt tagagcttat ctcagattta aatagccaaa ggaagacctc 4620 attgccttcc aggtgaaggt gcaaagtcat acatattaat gacctgacag ttaacattct 4680 gttgtttatt attgcctttc tccaccttag agagccataa ataactctct ggtgaagtga 4740 tttgctataa tgggggtgag gagtggggag acttctctgg tcattacact gctatttatt 4800 tctagaactc actatcagtg agcagtgcca gagtgttttc tctttgacct agaggtttca 4860 catcatagca aggagggaaa agtctcccca tctccttaca actgtgtgct aagtaagtaa 4920 cttggccaag ggtagttttc agctcaattt atagaatagt ccaaagagac tttgagaaac 4980 atggtgatag gcaggggcct ttcctaccat gtttcaatac ctacaaacct attgaaagag 5040 aacagtaggt aaaacatttc ctaaagttga agcaatagct tcgtagattc ttggttactt 5100 tatttttttt aatgctttac atttgataca actattgaag atcaatttta aaaatagctt 5160 tccagtaata tattttaagt aatatatatt ttaatatctg taaaaagtga cagtggaaga 5220 ctttgaattt ctcatatatg gtatgtttga tgtaggacct cactgttaag gcacaaatta 5280 tttcaaagga agttactcta aagacactca gattatttca gaaaaatgca ataaggggaa 5340 tagttttggg gtttattttt tattttaaaa gaaaattgac ttatttacca caagctattt 5400 ttttcccttc tggctgtaag gtttgtacag actggtttgg taaatgctaa acttttgtgt 5460 cttttgcctt tttaaaggaa ttgttaacat tggaattgag ggtatgtaca gagaagttgg 5520 tgtcaacacc atttaaaaag tcatattttt tcacaaatat agaaaatcat tttacataag 5580 aattttaagt atttgcaata aatatatgta tatagattgt atgtattcct atattcttat 5640 ttttcatttt attattaagt aaaagatcat taaaagtgaa aataaaaacc ttggagtttt 5700 ttggtgaatc ttgaggttta acatacatct gagagtggcg tgggtaagag tcctcagtta 5760 ctgccttata ctcctatggg atggttccca cagattgtat ggaagagagt aaaatgagga 5820 acttggtgat aaatcagggt agtgtatttc ttttggaatt taagtaaaac tgattaaatt 5880 ttcctt 5886 <210> 245 <211> 2400 <212> DNA <213> Homo sapiens <400> 245 gcctcccgcc cgccgcctct gtctccctct ctccacaaac tgcccaggag tgagtagctg 60 ctttcggtcc gccggacaca ccggacagat agacgtgcgg acggcccacc accccagccc 120 tccaactagt cagcctgcgc ctggcgcctc ccctctccag gtccatccgc catgtggccc 180 ctgtggcgcc tcgtgtctct gctggccctg agccaggccc tgccctttga gcagagaggc 240 ttctgggact tcaccctgga cgatgggcca ttcatgatga acgatgagga agcttcgggc 300 gctgacacct cgggcgtcct ggacccggac tctgtcacac ccacctacag cgccatgtgt 360 cctttcggct gccactgcca cctgcgggtg gttcagtgct ccgacctggg tctgaagtct 420 gtgcccaaag agatctcccc tgacaccacg ctgctggacc tgcagaacaa cgacatctcc 480 gagctccgca aggatgactt caagggtctc cagcacctct acgccctcgt cctggtgaac 540 aacaagatct ccaagatcca tgagaaggcc ttcagcccac tgcggaagct gcagaagctc 600 tacatctcca agaaccacct ggtggagatc ccgcccaacc tacccagctc cctggtggag 660 ctccgcatcc acgacaaccg catccgcaag gtgcccaagg gagtgttcag tgggctccgg 720 aacatgaact gcatcgagat gggcgggaac ccactggaga acagtggctt tgaacctgga 780 gccttcgatg gcctgaagct caactacctg cgcatctcag aggccaagct gactggcatc 840 cccaaagacc tccctgagac cctgaatgaa ctccacctag accacaacaa aatccaggcc 900 atcgaactgg aggacctgct tcgctactcc aagctgtaca ggctgggcct aggccacaac 960 cagatcagga tgatcgagaa cgggagcctg agcttcctgc ccaccctccg ggagctccac 1020 ttggacaaca acaagttggc cagggtgccc tcagggctcc cagacctcaa gctcctccag 1080 gtggtctatc tgcactccaa caacatcacc aaagtgggtg tcaacgactt ctgtcccatg 1140 ggcttcgggg tgaagcgggc ctactacaac ggcatcagcc tcttcaacaa ccccgtgccc 1200 tactgggagg tgcagccggc cactttccgc tgcgtcactg accgcctggc catccagttt 1260 ggcaactaca aaaagtagag gcagctgcag ccaccgcggg gcctcagtgg gggtctctgg 1320 ggaacacagc cagacatcct gatggggagg cagagccagg aagctaagcc agggcccagc 1380 tgcgtccaac ccagcccccc acctcaggtc cctgacccca gctcgatgcc ccatcaccgc 1440 ctctccctgg ctcccaaggg tgcaggtggg cgcaaggccc ggcccccatc acatgttccc 1500 ttggcctcag agctgcccct gctctcccac cacagccacc cagaggcacc ccatgaagct 1560 tttttctcgt tcactcccaa acccaagtgt ccaaggctcc agtcctagga gaacagtccc 1620 tgggtcagca gccaggaggc ggtccataag aatggggaca gtgggctctg ccagggctgc 1680 cgcacctgtc cagacacaca tgttctgttc ctcctcctca tgcatttcca gcctttcaac 1740 cctccccgac tctgcggctc ccctcagccc ccttgcaagt tcatggcctg tccctccaag 1800 acccctgctc cactggccct tcgaccagtc ctcccttctg ttctctcttt ccccgtcctt 1860 cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920 nnnnnnnnnn nnnnnnnnnn ntgtgcttcc tcagaccttt ctcgcttctg agcttggtgg 1980 cctgttccct ccatctctcc gaacctggct tcgcctgtcc ctttcactcc acaccctctg 2040 gccttctgcc ttgagctggg actgctttct gtctgtccgg cctgcaccca gcccctgccc 2100 acaaaacccc agggacagcg gtctccccag cctgccctgc tcaggccttg cccccaaacc 2160 tgtactgtcc cggaggaggt tgggaggtgg aggcccagca tcccgcgcag atgacaccat 2220 caaccgccag agtcccagac accggttttc ctagaagccc ctcaccccca ctggcccact 2280 ggtggctagg tctcccctta tccttctggt ccagcgcaag gaggggctgc ttctgaggtc 2340 ggtggctgtc tttccattaa agaaacaccg tgcaacgtga aaaaaacagc aagtcgggct 2400 <210> 246 <211> 2859 <212> DNA <213> Homo sapiens <400> 246 agatgttgcc ctgctggatc tgtcagcagc tgctcctcta catcttcttg gaacacagac 60 agagctaccc caagaaacag aatgcaatca gcagtaacaa gaagacaatg agcaaaagcc 120 cttccctttc atccagagcc agtgctggta tctatggctt tttcaaccag gctttcttgg 180 tgttttttat cttggtttgt ttgtttgaat tcctcagcaa catctacagc aaataatagc 240 cgttgcgagg gggaactccg cctcggagag agagtgttag tggtaggaca gagactgggc 300 accattaggt tctttgggac aacaaacttc gctccaggat attggtatgg tatagagctt 360 gaaaaacccc atggcaagaa tgatggttca gttggaggtg tgcagtattt tagctgttct 420 ccaagatatg gaatatttgc tcccccatcc agggtgcaaa gagtaacaga ttccctggat 480 accctttcag aaatttcttc aaataaacag aaccattctt atcctggttt taggagaagt 540 tttagcacaa cttctgcttc ttcccaaaag gagattaaca gaagaaatgc tttttccaaa 600 tcgaaagctg ctttgcgtcg cagttggagc agcaccccca ccgcaggtgg cattgaaggg 660 agcgtgaagc tgcacgaggg gtctcaggtc ctgctcacga gctccaatga gatgggtact 720 gttaggtatg tgggccccac tgactttgct tcaggtatct ggcttggact tgagctccga 780 agcgccaagg gaaaaaatga tgggtcagtg ggtgacaagc gctatttcac ctgtaagccg 840 aaccatggag tcttagttcg accgagcaga gtgacctatc ggggaattaa tgggtcaaaa 900 cttgtggatg agaattgtta agcttctaaa atattaaata agctcaaata tatatatttg 960 gtgtaaataa agagtccatg gtaaatggtt tactttattt agccatatta aaattttgaa 1020 aatatagtta tcttcttaaa aaccattata acaattcaga gagagttctt tacaaagcca 1080 tgaatatgaa ctatggggaa tcatggttct tttaaagcaa ttttcaaaat aagtaccaat 1140 taaagcttta ggttccaaga agattctggg actcaggaag aaaaagtgcc atcaggtgac 1200 cagctgttgc atttcttgct tattctgttt tgtttttgca catcataatg gatttttctt 1260 agtgccctaa ttgtgaaggg tttctctagc tttggttatg tgtaatgttc acgtgacctt 1320 ttttttgtca atcatttttg gaatttttct ttctttctgt gctttattac taataagtcc 1380 aatgagtgag tagtagctag atgactagta tgtagtttta tattttggta aaattatttg 1440 ccctttcaga aatgcctcat ctaaagatac atgataattt tggagttgga aggggcctta 1500 gaggctctcc agctctgctt cttgcccatt gccaaatact gaaatggaag cccgtcttac 1560 ctggggtcac taactggttg gttaactgag ctaagaatag actgtgggtc tcctcacttg 1620 tggcccagtg ctctttctgc tatacaaaat gtctaatctc agatttttct tctgctgctt 1680 gactgcttca tctggatgaa ctacaaaaaa cccatgatta aggtttatga attcaagtaa 1740 taattagatt ttttttgcac agacttactt aacttcctta ttggatatgt ttgtaacaca 1800 taaacacaaa gcacttttca aacatgatgc acttttatct ttgtgaataa tttactgtcc 1860 tttcctcctg ggatatgaga aacattttaa aaaacgtatt taacagaaga gagcaaataa 1920 agatatatca ggaaggatgt attagttatt tacttaaatg tttataatat ctggattttt 1980 tttgttttgt tactcataga actggtgttg tttgctgttt ttatttctct aattgttgca 2040 gagttctgcc tgttacaaag ctacagaact gtattgtttt tattttcctt cttgagcaca 2100 tgttaacaaa ctaagcttca cattagagtg atgtcataat gtaaaatgtt tgcattgtgg 2160 ttaggtattg aagtttatgt cctgtctgtg taaagattca tcttttattg taaatattta 2220 gactttacca cagaaatatt ggaacagttt gctttataag attaaaaagc atccttcaga 2280 atggagcttg ccttgtgctt agaaataata tgttgaacta ttttgcaata tactatttta 2340 aatctaaatt ctgtcacttc gctgcctttt taaaatagtg tggtatttca aatattgcta 2400 gagctatttt cctgaaatac atttgcaaaa taaggctgct ttgtaatcaa ggaatatttt 2460 tattgattga aggaaatgac tgtactgcga ttcaaaagta aacttatttt attatacaga 2520 ttatttctta aaaactctat ttatacctta acatgaaatc catgaccaca ccaaacttgg 2580 ttattcataa tttttcctgt taaatataaa acactgtaag ttaaaaacag taatgccaac 2640 attgaattta tttttgaggt caaagaacca gttgttctct ttatatttag atgaggatga 2700 ttgagtccat atactatgta tgtttacata tactatacat gcacattagg tgttttcatt 2760 tgtgttttgc ttatgaaatg tcatttaaag ttcacttctt gagcatcaat aaaaagggaa 2820 gctgtgtggt tttggaaaaa acaaaaagaa aagaaaaaa 2859 <210> 247 <211> 2949 <212> DNA <213> Homo sapiens <400> 247 gtgctgcacc ggcccccacc tcccggcttc cagaaagctc cccttgcttt ccgcggcatt 60 ctttgggcgt gagtcatgca ggtttgcagc cagccccaaa gggggtgtgt gcgcgagcag 120 agcgctataa atacggcgcc tcccagtgcc cacaacgcgg cgtcgccagg aggagcgcgc 180 gggcacaggg tgccgctgac cgaggcgtgc aaagactcca gaattggagg catgatgaag 240 actctgctgc tgtttgtggg gctgctgctg acctgggaga gtgggcaggt cctgggggac 300 cagacggtct cagacaatga gctccaggaa atgtccaatc agggaagtaa gtacgtcaat 360 aaggaaattc aaaatgctgt caacggggtg aaacagataa agactctcat agaaaaaaca 420 aacgaagagc gcaagacact gctcagcaac ctagaagaag ccaagaagaa gaaagaggat 480 gccctaaatg agaccaggga atcagagaca aagctgaagg agctcccagg agtgtgcaat 540 gagaccatga tggccctctg ggaagagtgt aagccctgcc tgaaacagac ctgcatgaag 600 ttctacgcac gcgtctgcag aagtggctca ggcctggttg gccgccagct tgaggagttc 660 ctgaaccaga gctcgccctt ctacttctgg atgaatggtg accgcatcga ctccctgctg 720 gagaacgacc ggcagcagac gcacatgctg gatgtcatgc aggaccactt cagccgcgcg 780 tccagcatca tagacgagct cttccaggac aggttcttca cccgggagcc ccaggatacc 840 taccactacc tgcccttcag cctgccccac cggaggcctc acttcttctt tcccaagtcc 900 cgcatcgtcc gcagcttgat gcccttctct ccgtacgagc ccctgaactt ccacgccatg 960 ttccagccct tccttgagat gatacacgag gctcagcagg ccatggacat ccacttccac 1020 agcccggcct tccagcaccc gccaacagaa ttcatacgag aaggcgacga tgaccggact 1080 gtgtgccggg agatccgcca caactccacg ggctgcctgc ggatgaagga ccagtgtgac 1140 aagtgccggg agatcttgtc tgtggactgt tccaccaaca acccctccca ggctaagctg 1200 cggcgggagc tcgacgaatc cctccaggtc gctgagaggt tgaccaggaa atacaacgag 1260 ctgctaaagt cctaccagtg gaagatgctc aacacctcct ccttgctgga gcagctgaac 1320 gagcagttta actgggtgtc ccggctggca aacctcacgc aaggcgaaga ccagtactat 1380 ctgcgggtca ccacggtggc ttcccacact tctgactcgg acgttccttc cggtgtcact 1440 gaggtggtcg tgaagctctt tgactctgat cccatcactg tgacggtccc tgtagaagtc 1500 tccaggaaga accctaaatt tatggagacc gtggcggaga aagcgctgca ggaataccgc 1560 aaaaagcacc gggaggagtg agatgtggat gttgcttttg cacctacggg ggcatctgag 1620 tccagctccc cccaagatga gctgcagccc ccccagagag agctctgcac gtcaccaagt 1680 aaccaggccc cagcctccag gcccccaact ccgcccagcc tctccccgct ctggatcctg 1740 cactctaaca ctcgactctg ctgctcatgg gaagaacaga attgctcctg catgcaacta 1800 attcaataaa actgtcttgt gagctgatcg cttggagggt cctcttttta tgttgagttg 1860 ctgcttcccg gcatgccttc attttgctat ggggggcagg caggggggat ggaaaataag 1920 tagaaacaaa aaagcagtgg ctaagatggt atagggactg tcataccagt gaagaataaa 1980 agggtgaaga ataaaaggga tatgatgaca aggttgatcc acttcaagaa ttgcttgctt 2040 tcaggaagag agatgtgttt caacaagcca actaaaatat attgctgcaa atggaagctt 2100 ttctgttcta ttataaaact gtcgatgtat tctgaccaag gtgcgacaat ctcctaaagg 2160 aatacactga aagttaagga gaagaatcag taagtgtaag gtgtacttgg tattataatg 2220 cataattgat gttttcgtta tgaaaacatt tggtgcccag aagtccaaat tatcagtttt 2280 atttgtaaga gctattgctt ttgcagcggt tttatttgta aaagctgttg atttcgagtt 2340 gtaagagctc agcatcccag gggcatcttc ttgactgtgg catttcctgt ccaccgccgg 2400 tttatatgat cttcatacct ttccctggac cacaggcgtt tctcggcttt tagtctgaac 2460 catagctggg ctgcagtacc ctacgctgcc agcaggtggc catgactacc cgtggtacca 2520 atctcagtct nncanntcag gcttttcgtt cattaacatt ctctgataga attctggtca 2580 tcagatgtac tgcaatggaa caaaactcat ctggctgcat cccaggtgtg tagcaaagtc 2640 cacatgtaaa tttatagctt agaatattct taagtcactg tcccttgtct ctctttgaag 2700 ttataaacaa caaacttaaa gcttagctta tgtccaaggt aagtatttta gcatggctgt 2760 caaggaaatt cagagtaaag tcagtgtgat tcacttaatg atatacatta attagaatta 2820 tggggtcaga ggtatttgct taagtgatca taattgtaaa gtatatgtca cattgtcaca 2880 ttaatgtcac actgtttcaa aagttacttt ttcttttcca ctgttatgtt gctagactct 2940 ggaactcac 2949 <210> 248 <211> 3612 <212> DNA <213> Homo sapiens <400> 248 aatgttaaaa catgaattta ttgcatctgt agcatcttac cttgagcacg gcttctttca 60 atgcttttat tttgcaatta taggtttatt ttcttccttt cctctctctt gagcttttta 120 aggtgttttc tgtcactcag ctggagactt taaatttcct atttatatta attatcaaat 180 tatttcatat atgagtcatt cagctcagcc ctttttggct ccttcttgca actcttactt 240 gtggatttat tgggcagttc agcgcctact ttcatgggca gactcaactg gcgagatttt 300 aactggaggg tgagagatgt cctggccacg gggccctgtt gctcacagtc cctggatcag 360 aggatggtgc cggatgggca ggtgctgagg atgcacatac cgccctcggg ttagcaccga 420 aggttcttgt gtcagacgtg aggcttcctt cctgggttct ttctggctgc gctagtccag 480 aagaccagca aacctgagat ggtctgaggt ggacgatgga gcctgaatgg agagcctggg 540 gcgtgagcca gggtctggga taccctggga cagagttaga tgcccctgca gacgtggatg 600 agcggctgaa gagtaaggga gcaggtcaca cgtggtgaca gacaggagag gctgctgtgc 660 catccagggg ctggggaagg agcccccgtg gagaggctcc atttcggcca cgtggctgct 720 gcagacaacc gggagtcagc gtcggcacaa acacgggtgc ctcgaaagag agcagtgccg 780 gcctggtgtc tccgggccca gctgccactg gcacaggcct ccgaaggggc aggagcagga 840 gcaggagcag aaagcgcaca tcagggctca tgctgtgcca gacatccacg aggagaatcc 900 aggccttggt ttggctccag ctgggcctgc ctggtggctg ccacttattg acttaagtcc 960 cagtgattca gctcctcatc tggaacacct cgggtcaccc ccgacaacgg tggtgggagg 1020 gagagcggcc tcctcctccc tggtggggcc tgtctgggtg aagcccctct gttcccgagg 1080 atcgtctgcc ttattgaaac catctaattg gagatccgca gattaggcta ccaagacaca 1140 gctgcctcca gcagaatttg tgtagtggac acttgtacgt gcactttgga gacagcaagc 1200 atgaggcctg cagctgacag ctttgagtgg ctgtgaacct gacttcatct cagatgtgac 1260 tcccaacccc catctcagat gtgactccca acccccagcc gggtgctccg agccatggcc 1320 gacaccatct tcggcagcgg gaatgatcag tgggtttgcc ccaatgaccg gcagcttgcc 1380 cttcgagcca agctgcagac gggctggtcc gtgcacacct accagacgga gaagcagagg 1440 aggaagcagc acctcagccc ggcggaggtg gaggccatcc tgcaggtcat ccagagggca 1500 gagcggctcg acgtcctgga gcagcagaga atcgggcggc tggtggagcg gctggagacc 1560 atgaggcgga atgtgatggg gaacggcctg tcccagtgtc tgctctgcgg ggaggtgctg 1620 ggcttcctgg gcagctcgtc ggtgttctgc aaagactgca ggaagaaagt ctgcaccaaa 1680 tgtgggatcg aggcctcccc tggccagaag cggcccctgt ggctgtgtaa gatctgcagt 1740 gagcaaagag aggtctggaa gaggtcgggg gcctggttct acaaagggct ccccaagtat 1800 atcttgcccc tgaagacccc tggccgagct gatgaccccc acttccgacc tttgcccacg 1860 gaaccggcag agcgagagcc cagaagctct gagaccagcc gcatctacac gtgggcccga 1920 ggaagagtgg tttccagtga cagtgacagt gactcggatc ttagctcctc cagcctagag 1980 gacagactcc catccactgg ggtcagggac cggaaaggcg acaaaccctg gaaggagtca 2040 ggtggcagcg tggaggcccc caggatgggg ttcacccacc cgccgggcca cctctctggg 2100 tgccagagca gcctggccag tggtgagacg gggacaggct ctgctgaccc gccaggggga 2160 ccccgccccg ggctgacccg aagggccccg gtaaaagaca cacctggacg agcccccgct 2220 gctgacgcag ctccagcagg cccctccagc tgcctgggct gaggtgtctg gtgcctggaa 2280 cagacttccc tgtggaggat tcctgccaga ccctgcccgg ctcctccctg accggtcctt 2340 gtgccctcac cagacaccct gttggccatg actcaacaaa ccagtgttgg gagccgtctg 2400 cctccccagc tcagtgcctt tctgcacccc ttctctcctg gggagctgtc tgcatccgcc 2460 accccctcca accactgccc tcagcccccg accttattta ttaccctccc ctcccacacc 2520 cccaatctac ctggtgatga ttttaagttt gcgcgtgtct tgggttgggc tggggggttt 2580 cccacatgca gtgtcagagg ggccgcccgg tggggctatc tccgttgcta tattaatggc 2640 aagactaaat gaaacctagg gcacggcctc cgaagctgcg tgtggcccct tagaggtgag 2700 catcagagcc agagcagtga gggggagact cacccaccct ctccctctcc cttcagctct 2760 gggaggcagg cgcagtgccc ccctcccatg ggctggccca ggaccgcggg tgaaacctgg 2820 gtctgtttag tttctttggn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3120 nnnnnnnnnn nnnnnnnnna tcctattagg tttctttgaa tcccctcatg gcctgcctgg 3180 tttttgctca gcctgtcttc agcttgagga gctgggaagc tctggtggat gctatgaact 3240 cacttgctga agagcagcgt tcaggtgcat ccccagccag ggcacgtggc tccctcagcc 3300 atgaattcac ttctcttcag gaggtttggc ttggcatgaa aatacttcat tcagagtatg 3360 ggcaaatgct tctggaaaac ccttccctga agagagagaa cgtgtgtgtg tgtgtcggtg 3420 atcacaccct cccatccttc ctgcctcctg ccccaaaccc cgggttcctg ggtctggaag 3480 ggccttctct ccaagctggg agctcctggg cccccaccat tcactttttg tccttgctgc 3540 tggcaaacag taaagaaact cactttccct gtggcacgtt atgcttcaga attaaaacaa 3600 tgaagattaa aa 3612 <210> 249 <211> 5742 <212> DNA <213> Homo sapiens <400> 249 cgcgcgtggt tcccgcgcct gggggtgcgc gggagaggcg cgaatccgag tgccgcgcgc 60 ggcccgggga cttgcacggg cgtgcggggt ggaaccgcag gaagcggagc tctcgggttc 120 ccgccccgcc ccgccccgcc ggcggcggag gcagcgagcg cgagagccca gcggagtcgc 180 tgggagcctg aggcaccgag acacaaaggc aggcgggatg cgggagcagg caaagggaaa 240 gcgaaagccg cgcgcccggc cggtgactgg gtgaaggcgc cgcgcagctt tcccgacgcc 300 ggctgtaccc ggacctcctg gtcgagcctg gcgcgccgca gccatggcca tcgctcaact 360 ggccacggag tacgtgttct cggatttctt gctgaaggag cccacggagc ccaagttcaa 420 ggggctgcga ctggagctgg ctgtggacaa gatggtcacg tgcattgcgg tggggctgcc 480 cctgctgctc atctcgctgg ccttcgcgca ggagatctcg attggtacac agataagctg 540 tttctctcca agttctttct cctggcgtca ggctgccttt gtggattcat attgctgggc 600 ggctgttcag cagaagaact cactgcagag cgagtctgga aacctcccac tgtggctgca 660 taagtttttc ccctacatcc tgctgctctt tgcgatcctc ctgtacctgc ccccgctgtt 720 ctggcgtttc gcagctgctc ctcatatttg ctcagacttg aagtttatca tggaagaact 780 tgacaaagtt tacaaccgtg caattaaggc tgcaaagagt gcgcgtgacc ttgacatgag 840 agatggagcc tgctcagttc caggtgttac cgagaactta gggcaaagtt tgtgggaggt 900 atctgaaagc cacttcaagt acccaattgt ggagcagtac ttgaagacaa agaaaaattc 960 taataattta atcatcaagt acattagctg ccgcctgctg acactcatca ttatactgtt 1020 agcgtgtatc tacctgggct attacttcag cctctcctca ctctcagacg agtttgtgtg 1080 cagcatcaaa tcagggatcc tgagaaacga cagcaccgtg cccgatcagt ttcagtgcaa 1140 actcattgcc gtgggcatct tccagttgct cagtgtcatt aaccttgtgg tttatgtcct 1200 gctggctccc gtggttgtct acacgctgtt tgttccattc cgacagaaga cagatgttct 1260 caaagtgtac gaaatcctcc ccacttttga tgttctgcat ttcaaatctg aagggtacaa 1320 cgatttgagc ctctacaatc tcttcttgga ggaaaatata agtgaggtca agtcatacaa 1380 gtgtcttaag gtactggaga atattaagag cagtggtcag gggatcgacc caatgctact 1440 cctgacaaac cttggcatga tcaagatgga tgttgttgat ggcaaaactc ccatgtctgc 1500 agagatgaga gaggagcagg ggaaccagac ggcagagctc caaggtatga acatagacag 1560 tgaaactaaa gcaaataatg gagagaagaa tgcccgacag agacttctgg attcttcttg 1620 ctgatgattt ttttccttga gctgtaaatc tgtgacttct gcgacatggg atttaatttg 1680 gctaaagcac ccctgttggt ttcacagctg gtttgcaata aatggttctt ggtggagata 1740 ctgagcatgt cttattgagt ccctaatgga aatggtgatc aacaaaaggt tatggaagaa 1800 tggtttatga acttcccata ggaagcacct gagagatagt aaactgcagc aagtaactat 1860 gtgtaagtcc tcatcaaatg aaaagcagaa agacaagaac aattagtcaa gagcagtagc 1920 cctgtcagag cctcggagca atacctttct gtacccgtgg tgagacaaga cccagagcta 1980 ctggaaaaca agcactttgg aagatttgtt ttgttttcat ggaataataa tatgtcagga 2040 tataatttaa cgtgagtttc ttatgtgccc ttaaagactg ttagacaaga aaagcattca 2100 ctggctaata atccataggt cgacctatgt cctaagttag gtgtaaggtc cgatgccttg 2160 gcccacactc gagctctctt tacattgtta gttgtcaacc ttggctgatg gaaatcccgt 2220 aaccactatt tgttgcactg tgccttgaag ggcagcaggc ccaagtgctg ctctgactga 2280 aaactgagtt aacaagacga aatctaaagg atattcacag tgacttcaat tcaggaagaa 2340 tgcttccaaa agagcccagt ggggaaatct gacatcacag aagacattaa ttcagtcact 2400 ttcaaagagt ttgtctacag gcggtttctc tgttatcaaa ggcatttgaa ataggatttt 2460 acttaaacaa taatggaaca caggagtatt taaagtgaag aacactttgc ctgaatgtga 2520 tcagggcaca taagtgacat tggcgtgctt catatggcgt gcttggagcc agaaaaactt 2580 agcggtttat tttgtttata tttaagcaca gctttaaaaa attcattatc gtttattcag 2640 tgtccgaatt gaggccattt gggaagaaaa ttctagcact ggtggagaat tatagaataa 2700 agattataaa tggttggata agacaaatgt aagcttattt cataaacatt taaagctgat 2760 tcagaacatg ttaaaaactg ttcccaattc caactatgta aatagatcct atgttcacat 2820 tttacacaca cacacacaaa tctttaacat ctgtggaact tcccagtttt agtcttagaa 2880 agttagcatg ttgcataagt tcagtaatcc tcaggaacct ccaagtttac ttttagctct 2940 tacggacagt tgtttacata atctaattac tgttttctga agaacggaaa ttatataagc 3000 tgctgtctgc cttttggaat attcagaaaa gcagatttta tttgtacttc tgtgatgttt 3060 tctgaaatgg aaagctgatg ataaatatca aagtagcaat cagtgcgtta aattattctg 3120 ttacatgata tttattactg ttgaattatt ctgtgactta gaaatggcag taacctaaat 3180 aatggaattt gcaaaattat tatattgccg tatctgagat gttccatcac aagtttctac 3240 actggtttct tttgaaaatt taaaaagatt tacgagatac attttctagg atatgatttt 3300 ttttttacaa aaagcttcat cttctgtaga ctatccttaa tttctatttt gaaacggtaa 3360 aaattgatat tttaggacac caggaagtct ccaagccatt cccactctct gaactccagt 3420 agggtctgtg atgtcccagg caccagtacc aagttggatg tgcagatatg cataggcagg 3480 tcccatcctt gaggacttca gagtccagta aaaggcagca gaaacatggg ctggtgccta 3540 agaggagaaa gcgtagccac agtaaaggct atgccagaaa actcctagca aatgctctgt 3600 gttcttggga gagggcacat tgtttttgtt ttctctccta tagttcctgt aactgctggt 3660 tttgagaata tagtaatcat ttttcccaga ggcagatgac caccttaagg ttctttagct 3720 gcaaatcctc taggttgaag tttgtgtgaa atagtcacag tgattttgaa tagtaaggaa 3780 tccagttgcc ttttgaacct tccctcacag ggatgagaga acaagcctgt ggaggttgtg 3840 gagctactgg taaacaactg tcagggcccc agaaggctga tgtggaggcc tggggataca 3900 tttcatctaa taaaagtatt actaggtatc agtatcagta ataaaagtat tataataaag 3960 tatcagtaat aaaagtatta taataaaaag tattattagg acaggtaaac tcatccatct 4020 actgtgagct gctggcttgg agaacgactt ttgaggagcc agtttcctga ggagaaatgc 4080 ttttataaag cactcattgc tttgtaaaag gagacaaaac tgatcctaaa tgaccactcc 4140 agggttgctg attttgtttc tggctcatgt ctgcctagta aaccaccagc aagctgctga 4200 accaggctgg aaacaacatt gttgcaactg ggagggacat agagtactgt gaaagcagcg 4260 ttccaacaca tcttcacttt tacaaaggga taggcagaga cttccaacat agaggttctt 4320 aaacttcgag gggttacaat ccccttgcaa atatttttat agctatggac cctctcctca 4380 gatctacagc caacattttc agtgcacctt aggaggtcat tttagtccac gcctctgaaa 4440 aagctgcact ccaacggctg aagagcaagc catacggccg agaatggggc tccctttgcc 4500 ttcatgaaag ctacttcccc caacactaag actcagctgt acgtttgctt agctcagtca 4560 catttacatt cttctgggtg aactgtacct tttgagtacc tgccttcatt ttctagaatc 4620 agacctaact aacaaggtca gtagaagcct gggcagcagc gggcctggaa agacgaggca 4680 gccagcatga actgctgttc tctccctgac cacaaggcgt cgtcttcctc cagggtcaag 4740 taattgttct tgttccgcct cacaggaatg tggggaggaa ggacgtaaca ctataaaatg 4800 ctgcgtccta ccttaaactt gtactgtgag aaagctggaa acttccacct gtacagtggg 4860 tctggtttgc atgtttagtt tcatttgtgg gaactgcttg tccaagagtg agctcaggtc 4920 agggcagttt gtgcctatga gaattagctc agctatcagg caggttttta gacacctttt 4980 taaaatgtgc tcgtgtttgg tttgttttgc ttactgtcag tcctgggtca atcaaaggtt 5040 tgtaagggtg agaattttta tgcactgcta tatcgcaagt gcttaaaaca gagactggcc 5100 cagatgaggc attcttcaaa tgtttgttga aatgaatgga caaactctta ggataaatcc 5160 taattggcat ctccaggaga ctctggattt tggcagccct ctcctgccgg accacacacc 5220 tcccttgggg gcctctccat gcccagtccc ctcctgtgtc tttcccctcc actcgggcac 5280 tggttctttc atcttggcaa catgcttcct gaagcctctc tgtgctagaa ccacattccc 5340 ttgactttgc ttcttcaact gaccacccct tctccctctc tcaccaccaa acttctagaa 5400 agggcggtcc acactcctgg atcccactgc cttacctccc agtcctgagt taacctggtt 5460 tctgcttccc tcctactgcc agactgctca gctcaaggtc accagtgaac acccgacaaa 5520 cacaccatga ctcccttttc ttctgatcta acctttcacc aagtctgaaa ctccctctca 5580 attctttgct gactctcctc tgcctcctat caggccctct cagcttcttc catctgctca 5640 tcctcttgga tcttctcttt catgttgata tctgaatcaa tactatctta ccacattcta 5700 caattatctg ttcccgggtg tcagctataa cccatcggtg at 5742 <210> 250 <211> 2245 <212> DNA <213> Homo sapiens <400> 250 ccggtgcgtc ctgggtctgt ctgcgcggag ttccccgggg cgcgaggaga ggggactgga 60 gaaagaggag ggccgggcag cggaggggag gaggcggtgc gtgcctcgcc tgccaaaggg 120 agatccgctc ctctgcgtgc gatccccggc gcccgcgcgc gcccacagcg ctccgccaga 180 gctgccgccg cggactcgcc gggagtgggg gtctccgctg gtgccagccc gcttctggag 240 accctccgcc tcctgccaac ccctgctctt ccaggtcggg ccccggggtt ctgcggctgt 300 tagggacaga ggcaaagaag ggcaggacgg tccggtttcc cgtggatgtt cccgcccgag 360 aaagacagca agttgtgtgt gcgcccggga cgcgggaggg aaggtagccg ccgcccgcca 420 gccatggacc atcatcttta gtgcagagga tggaaagttg atgcccagta agactgaaga 480 tccattctgc attacggaac tgtggattat ctgtgggtcc ctggtgattt cacaccttca 540 ttcactcctg cagtccctga acacttactt ggggtcctca ttgccctatc tggtgaaaga 600 tggcatccag cctgacttgt actggagtaa tctgggcttt gctgtctttt ctttgtgctg 660 ccacctcctg cgtggggttc tttatgcctt actggctctg gggatcacag ctgggcaagc 720 ctgtgtcctt cggtaccttc cggaggtgct catatcctgt gcatgatgag agtcggcaga 780 tgatggtgat ggtggaggaa tgtgggcgct atgcctcctt ccagggcatc cccagcgcag 840 aatggaggat ctgcaccata gtgaccggcc tgggttgtgg cctcctcctc ctggtggcgc 900 tcactgccct catgggttgc tgtgtttccg acctcatctc caggacagtg ggaagagtgg 960 ctggaggaat tcagtttctt gggggcttgt tgattggtgc tggctgtgcc ctctacccct 1020 tgggctggga cagtgaggaa gtccggcaga cttgtggcta cacttctggc cagtttgacc 1080 tggggaagtg tgaaatcggc tgggcctact actgcacggg agcaggtgcc actgccgcca 1140 tgctgctgtg cacgtggctg gcttgctttt cgggcaagaa acagaagcac tacccatact 1200 gagatggagc taccaagagc agacagagga gaagatgggc caaaggggct tggagaggtc 1260 aaaacatcca cctaccttca aaaggtggga tagtagttct aatccaatac aatgctaata 1320 aaatgaaacc cgataaaatc aggaacatga tataggaagg aaggattgta ggagatttgt 1380 gggggaaaaa aaaggagagt atagaatgat ggagaaaaat ggaccaaagg ctaaaaatat 1440 tgcagggcat cgggtgtttc tattccacag agtattgtta atgtacaaca cacacacaca 1500 cacacacaca cacacacaca cacacacaca acaaatctac atatacaaac aagggtttgg 1560 gttttagttt tttttttttt aaggtgagga ctcagaaaat caaagggcta gtagaaacag 1620 tgttatgttg ggaagcaggg tacccccaaa gatgttccct gtaggtcacg gcactcccaa 1680 aagcacacaa gcacatacag acatatgcat ccccacacac gcctatgcac aaacgtggat 1740 tatcgcacag actgggaggt ttagtggtgc atttctcctc tgttttcttt ttaatataca 1800 tttaaaatac agtattatca ctttataaaa catacattaa gcctaataaa tggaccaata 1860 agccaaacta tcagtatttt gtatatcctg cataaactct aatttagttc ctcaacatat 1920 tttcagtgtt tatgcagacc tttagagtta agcctttgta tttccatgtt attccacaat 1980 atgcaatatt tctctgagta gcttctgcta tgatattctt atgaagaaaa ggggcaactt 2040 tctgtccact ataggagaga attcagccga agatatgaga gtaatgagag acattttcca 2100 gtcattggat cgtgttttct tttgtccatt attgtactgt gctgtaccac atttatttct 2160 atattcattt tgtaaaaaat ttaaaagtgc tattttgttt gtatttgaaa atctctgtga 2220 ataaattctc tctttgatca atagc 2245 <210> 251 <211> 1565 <212> DNA <213> Homo sapiens <400> 251 agaaccacag cacatgcttt gaagtattca gtggtccttg agttgaatga ggaccaccgg 60 aaggtgagga ggaccacccc cgtcccactg ttccccaacg agaacctccc cagcaagatg 120 ctcctggtct atgatctcta cttgtctcct aagctgtggg ctctggccac cccccagaag 180 aatggaaggg tgcaagagaa ggtgatggaa cacctgctca agctttttgg gacttttgga 240 gtcatctcat cagtgcggat cctcaaacct gggagagagc tgccccctga catccggagg 300 atcagcagcc gctacagcca agtggggacc caggagtgcg ccatcgtgga gttcgaggag 360 gtggaagcag ccatcaaagc ccatgagttc atgatcacag aatctcaggg caaagagaac 420 atgaaagctg tcctgattgg tatgaagcca cccaaaaaga aacctgccaa agacaaaaat 480 catgacgagg agcccactgc gagcatccac ctgaacaagt ccctgaacaa gagagtcgag 540 gagcttcagt acatgggtga tgagtcttct gccaacagct cctctgaccc cgagagcaac 600 cccacatccc ctatggcggg ccgacggcac gcggccacca acaagctcag cccgtctggc 660 caccagaatc tctttctgag tccaaatgcc tccccgtgca caagtccttg gagcagcccc 720 ttggcccaac gcaaaggcgt ttccagaaag tccccactgg cggaggaagg tagactgaac 780 tgcagcacca gccctgagat cttccgcaag tgtatggatt attcctctga cagcagcgtc 840 actccctctg gcagcccctg ggtccggagg cgtcgccaag ccgagatggg gacccaggag 900 aaaagccccg gtacgagtcc cctgctctcc cggaagatgc agactgcaga tgggctaccc 960 gtaggggtgc tgaggttgcc caggggtcct gacaacacca gaggatttca tggccatgag 1020 aggagcaggg cctgtgtata aataccttct atttttaata caagctccac tgaaaaccac 1080 cttcgttttc aaggttctga caaacacctg gcatgacaga atggaattcg ttcccctttg 1140 agagattttt tattcatgta gacctcttaa tttatctatc tgtaatatac ataaatcggt 1200 acgccatggt ttgaagacca ccttctagtt caggactcct gttcttccca gcatggccac 1260 tattttgatg atggctgatg tgtgtgagtg tgatggccct gaagggctgt aggacggagg 1320 ttccctgggg gaagtctgtt ctttggtatg gaatttttct ctcttctttg gtatggaatt 1380 tttcccttca gtgactgagc tgtcctcgat aggccatgca agggcttcct gagagttcag 1440 gaaagttctc ttgtgcaaca gcaagtagct aagcctatag catggtgtct tgtaggacca 1500 aatcgatgtt acctgtcaag taaataaata ataaaacacc caactgggag tgctgacttt 1560 gaggt 1565 <210> 252 <211> 2791 <212> DNA <213> Homo sapiens <400> 252 ctgggattac aggtcgcgct gaaattcaga ctgaccagga ccaaacccag accttgctac 60 cctgccctgc tgcctctccg ctgaagatgg aagaggaggg aggaagccct ggcaggagtg 120 acctgaccgg gcacggccca gtgccatatc gtcattatct gggaattcca gggctgtcct 180 tgggatccca gcccagtgct cctgcgtgcc aagtgatctt gaagggtctg aaatagggag 240 cagcaagagt gagccatgga gctacgtgtg gggaacaagt accgcctggg acggaagatc 300 gggagcgggt ccttcggaga tatctacctg ggtgccaaca tcgcctctgg tgaggaagtc 360 gccatcaagc tggagtgtgt gaagacaaag cacccccagc tgcacatcga gagcaagttc 420 tacaagatga tgcagggtgg cgtggggatc ccgtccatca agtggtgcgg agctgagggc 480 gactacaacg tgatggtcat ggagctgctg gggcctagcc tcgaggacct gttcaacttc 540 tgttcccgca aattcagcct caagacggtg ctgctcttgg ccgaccagat gatcagccgc 600 atcgagtata tccactccaa gaacttcatc caccgggacg tcaagcccga caacttcctc 660 atggggctgg ggaagaaggg caacctggtc tacatcatcg acttcggcct ggccaagaag 720 taccgggacg cccgcaccca ccagcacatt ccctaccggg aaaacaagaa cctgaccggc 780 acggcccgct acgcttccat caacacgcac ctgggcattg agcaaagccg tcgagatgac 840 ctggagagcc tgggctacgt gctcatgtac ttcaacctgg gctccctgcc ctggcagggg 900 ctcaaagcag ccaccaagcg ccagaagtat gaacggatca gcgagaagaa gatgtcaacg 960 cccatcgagg tcctctgcaa aggctatccc tccgaattct caacatacct caacttctgc 1020 cgctccctgc ggtttgacga caagcccgac tactcttacc tacgtcagct cttccgcaac 1080 ctcttccacc ggcagggctt ctcctatgac tacgtctttg actggaacat gctgaaattc 1140 ggtgcagccc ggaatcccga ggatgtggac cgggagcggc gagaacacga acgcgaggag 1200 aggatggggc agctacgggg gtccgcgacc cgagccctgc cccctggccc acccacgggg 1260 gccactgcca accggctccg cagtgccgcc gagcccgtgg cttccacgcc agcctcccgc 1320 atccagccgg ctggcaatac ttctcccaga gcgatctcgc gggtcgaccg ggagaggaag 1380 gtgagtatga ggctgcacag gggtgcgccc gccaacgtct cctcctcaga cctcactggg 1440 cggcaagagg tctcccggat cccagcctca cagacaagtg tgccatttga ccatctcggg 1500 aagtgaggag agcccccatt ggaccagtgt ttgcttagtg tcttcacnnn nnnnnnnnnn 1560 nnnnnnnnnn nnnnnnnnnn ncaaaaataa accactcaaa agaacaacaa aaaaacccag 1620 cacaaaaccg acgatggagt ttgtttcttt gatttctttg ccaatggcaa gaagatgaga 1680 tgccctcagc actgaggatt cttgccccct tgtggtgccc gctgccccca accttcaggc 1740 tgccagatgc tcccctgaca acaccaggct acaggagcca gacgccaggg cctgcccggc 1800 ctcctgttcc tgcccccacc caccacctgc ctggagagga acgggtcggg tccgtgtcgg 1860 agaagtgaca ggtcccagag ccaaagccgg ccctcaagca tcatcaggga gtggtgtagt 1920 cagttgaagg cagttcccac cgagttttcc gagcctcaga atccaggaga tacgcacagc 1980 cccacccact ctgagatgac agtggctgac ttcccgtgct gggcttttcc attgtccccc 2040 tggcctccag gctcctcctc tgcctctcca tggagtgggt ggggaggtgg tgggggccgg 2100 cgtccccnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntgacct gtgtttccca 2160 agacagcagg tgccacggcc cgccccgcct gccagcccga attcccgttc tcctgtgtct 2220 actaacaagg acatgggggt gggcggtgac ctccgcatcc ctcagagctc agagggtcct 2280 cgctgccacc ggtccccccc tagcccgtca tcagccggtg gcagctccat cttccattcc 2340 tggttttagg gcagaatcca tggagactgc ttccagaagg catctggctc tgagttataa 2400 attacttccc tggtcctgac agtcacctgg ggtcccccct ctccctggtt ccacctttct 2460 gaggaggagc ctggagtcag ggctgggttt tggattaacc catccttcct agttaacacc 2520 tttttgtttt tattttattt tatttttgtt tgttttctcc gtgtgtgtgt tttcctaatt 2580 tatttacctc tgtttcccct ttttcctttt tttttttaat taaagagcaa agctttttat 2640 tactttgtaa tttaaaaaac tgaaaaaaaa aaaactgaag aactttgggg ggaattttgt 2700 acttttttcc tgtgtaaata ttggactttt ttgagcttta tcgtggttgt taatttgaag 2760 taataaagta gaaaagataa agtgaaaaaa a 2791 <210> 253 <211> 760 <212> DNA <213> Homo sapiens <400> 253 agggatgagg gcaagcccta caaaaagacc actgtaatca tttccttatt cttcctattc 60 attggagaaa ggagggtggc tagatatttt aatcttaatt gcttaacagt gtgtacagtt 120 gaaccatatt ggtctttttc tatcttaggt atattctttc ttgataatca atactttaag 180 aagtacagaa agaaactatc tcaaattata ctacttgcat ttctgttttt ttaatttcta 240 ttttaagact ttcattgtga attttgaaag tatataaaac atgctttttc tattttagaa 300 agtttctgta tcaacttaca gatatcagga tctttgcttt tctttgtttt attactaaga 360 gttatttcaa atctattgat gtcaggagga agatcactaa aggagcaagg agaaaaagaa 420 ttaacaaaat gttttggcat caaactacct tatttcttta gttctagtat caaataaacc 480 ccctatttct gctttaaaaa aaaaaacagt gtgctagacc taaaaccaga ttcacaacat 540 attttattat ttggtataca gaagacacgc agattacaca cttttcctac catctttaac 600 ctcctaaact aataattcat tcaaataagt actggaaacc ctagtaaatg ttttgtattt 660 gtgggttagt aaatgttttt tgacttgcta attcatgtta ataactaagt ggaaaaacca 720 agggcatagc acttcacaaa taaaggtgaa caaacaacag 760 <210> 254 <211> 2913 <212> DNA <213> Homo sapiens <400> 254 cctgtagctt agacttatag aaagtgatcc gcctgcctgc agaggcgccc ttttcagctg 60 ctgctcgcca gaagcccttg attccactgg ttgacatggc agcagttact ggcaagaggg 120 agaaaggacg ctgccgccta agagtgcaag gctgctcagg tctccaagcg ccgtaggagg 180 tcacctggca gtgactgtag ggagctgggt catagtgcac gtcgtgggta ttaggaaagc 240 ctgtattctt tcaatgaatg tcagtaggac cttcctttag ctgtaagact tggtgggcgg 300 ggtggggtgg ggagggagga aagggtagga agggtgggaa gggagaagca gacatagtca 360 tttatgattt gaaagttgga aatttgtacc atctgtttga gtatatgcac atttaaaaaa 420 tatcatatag taaatgcaaa catgccaagt attttataaa gattaataac agacctactc 480 ttacctggca gtttacttaa cttactgttt tgagtcctaa acttagagtt gttaatgctt 540 atatataatc taaccaaaga gttacccagt agggttttag tttttgaact tttattttct 600 tgttgattat aaatcctgat tttggaatct attgcgcaaa agaagtttca ttttggttac 660 ttagacctaa gatcacttat taaaaatcct tattttctcc aagcccagca aacgttgact 720 tctgggcaaa cctgaaaacc tgaaaatgcc actttcatgc agtttgtttg aagttaagtg 780 gaatcctttc aaatgacgag ctgcagagaa ctcagcacca agggctgcct atctgtagat 840 agctgtaaaa tggaatattt ttaaatgaag gcaaataagt acttaaaagt gagctgagca 900 ataaaatggt ccaataatag gtaaatgcaa cagaaacaga aggagacctg gttgccttat 960 gcctttactc ttacatggaa taaattccca atgcatatcc tatgtaaacc ataagtgaag 1020 ggaaataaac ctcgtcatgc tccatgctgt gaggtgtcct ttggatattc tgtgatgaca 1080 gagaagccta ttttgttttg ttttcagcat ctttctctga tgtacgtttt taaggatttt 1140 gtaagagctg ttttcagtgt ttaaattagt gctatttttc cttgttttta aaaatgaatc 1200 tcgtactgta tcttactatg tccatacaga tgttacaaat cgacagtttt attcttagac 1260 tcatgtgatc caagctgtat ataccatata taaacatttt acatgaatca tttagttttt 1320 taattcattt actaatgcta taaaatttcc tatattaccc cagtaatttg catcagctgg 1380 tttatatact aaagcaacat gttttgatga gtttcttaca tccttatcga ggaattgggt 1440 taggaaaaaa tacataattg taaaactgag tttgctgtat tatacttttt ttcttgagta 1500 ttagttgtat tactaatcat atgttgatta actgtctact taaagtcaag gtacctgtat 1560 ttttaatcca ctaatttttt tttagttggg aaatagattt caggtctttt attagactaa 1620 cattttttga gaagtaaaat tgacttcata tacaaagcct gtaattttag gcgaaatgga 1680 agcagaaatc taggaagttg tgcttgcttg tatgttgagt ttggtctcag actaagtaat 1740 gcatcagaat tcatctgttt gaagcctgaa ataatttagg actctgattc actgaccaaa 1800 agtcagtgtt gcagagattt ctctaccccg tatggtattt tgttagattg ttcaacagga 1860 agcacatgat tgagaacatc ttgggacaga ccaaaaccac tgacagatgg caaggctcgg 1920 cgattctgat ttcccttctc aaatctgctc aactccaaga gtcttgagaa actgctaaaa 1980 ttttgcctct gtcactcaag tcttacaaat gttatcttgt aaacctttga ggtgaactat 2040 tccactgtct tgtacatagg catcttattc actgcaccct gtcacaccca gcaccccccg 2100 ccccgcacat tatttgaaag actgggaatt taatggttag ggacagtaaa tctacttctt 2160 tttccaggga cgactgtccc ctctaaagtt aaagtcaata caagaaaact gtctattttt 2220 agcctaaagt aaaggctgtg aagaaaattc attttacatt gggtagacag taaaaaacaa 2280 gtaaaataac ttgacatgag cacctttaga tcccttcccc tccatgggct ttgggccaca 2340 gaatgaacct ttgaggcctg taaagtggat tgtaatttcc tataagctgt aatagtggag 2400 gtattgtggg ttcatttgag taagccctcc aaagatacca ttcaaataac ctgggagaat 2460 gtcataaatt attcagataa ttatcactgc atgaatctga ttcagaggca tgcatttaca 2520 tatgttgccc taattaccat ttgatgatca taaatacaag tgaatgacat tggactttta 2580 gtaacaaact taatttttaa aaaggtgtag acaatggtgg ttnnnnnnnn nnnnnnnnng 2640 gtaccaggtt ctgtgtgttt gcaccaagta attgacatgt tttttgttta atacatgtgg 2700 accatgaaca gtattcattc tactttttca aatgatatgc tgtagaaaat attccttgaa 2760 gatgtgagat ttaaaaattt ttccctttca atgttgtttt aattgtattt cttacttggt 2820 ttttttgatt gatagcacag tgataaatca taatactaga caaaattgtc ttctctttca 2880 aaccagagcc atatatatgt ctgtatatat ggg 2913 <210> 255 <211> 494 <212> DNA <213> Homo sapiens <400> 255 gaatggactc tcccttagct gagagagcca gacagactcc atcttcgctc tttccctggc 60 agccccttcc tcaaggactt aacttgtgca agctgactcc cagcacatcc aagaatgcag 120 ttaactgata agatactgtg gcgagctata tccgcagttc ccaggaattc gtctgattga 180 taacgcccaa agccccgcgt ctatcacctt gtaatagtct taaagcccct gcacctggaa 240 ctgtttactt tcctgtaacc atttatcctt ttaacttttt tgcctacttt acttctgtaa 300 aattgtttta actagactcc cctccccttt ctaaaccaaa gtataaaaga aaatctagcc 360 ccttctttgg ggccgagaga attttgagca ctagtcgtct ctaggtcgcc ggctaataaa 420 ggactcctga attaggctca aagtgtggtg tttctctgta actcacttgg ttacaacact 480 ttaaatatgt acaa 494 <210> 256 <211> 4224 <212> DNA <213> Homo sapiens <400> 256 acgtgtagcg attttaccag gggtcccggc tccgggagga gacgtgcaat ccggagcccc 60 gacattggca tgactagaag ttgttcactt tctggggatg ggacataagc tggtttagaa 120 gtgtagtgaa acgctgaccc tcacagaact ccctggggtg gtgtagaaaa gagatgctca 180 gattttctaa ggggaggcaa aaataactca ttgtttacag ctccaaagca tgaactcctt 240 gaggggaagg tgggtgaaga acaattcact tcttcatttc ttactgggtc ttagagctgg 300 gtgtgatggg caccgaggcc aacccctctg gattgtgtca tcttttcacc ccttcacccc 360 cagactgtct aataatacac acatcatacc ttgtctccgt ctctggaggc aaagttctct 420 gtaaatgccc ttccctatct ccaaaaagga gaagaccagc agtaagttct gtttttctgt 480 gggagagaaa gaatcctaga ggcaggtgac ccacctggag ctggaaagcc cactccacga 540 tgctagacag ctctctacct tcctgtggtg gcccctgggc ctggcattcc caggggacct 600 gctggcagga ggaggaacga gggctttata actttggtta taacttttgg tctttgttct 660 gattctcagt gtatcttcct ccgctggtta ctaaagtgtt cactgataag tatgttaact 720 aatgatcgag acagtaacga aaaatgctgg cactgggatt ctctcccttc ccagacctac 780 ctgctggtat ttcctgggac cttgaccctg ccccaccccc tcagccgtgc ccatctctgc 840 agactcccag atcacatctg ggctgatggg ctggcccagg cctgtccctc ccttcttgcc 900 cccagttctg ggctccacct ctgccctctt ctgtgctgtc ccattaggga agtcccttgg 960 cctgtctatt tttcagttcc caattagaag tctagaacct gacaactcca ggagttcttg 1020 ggaggaccag tacaacgttc taaaaagcct gagacgcctt acaaaaagca agtatcattt 1080 ggagtacaat tcctaatctg ttcatgtcct gctgaaggag ggaaggaggg agaggaaggc 1140 aggggagttg atgcattcat ataacaaaca ctgctgggtg tctgggtgcc cagagcaaag 1200 ctgggccagg ccttcaccag atcaagcccc acagaccagc tggtgcccat gcgctgctgg 1260 tggtttgggg cctcctgttc ctcctctagc tgggagtaat cacagttgtc tgacctgatt 1320 ccaacttaag gtccccactc tcttgcccca tcaagaatcc ctgattattt acttttccct 1380 agaaaatctg gggaaattcc cacattttaa ttttgcagca gaatcttttg agcagctttt 1440 ggaaccacag tgtttgccaa gataagagtt tgagaatcca gcagccctgg gtgcctggct 1500 gaatttggtt tcctgcatgt gctgggtgtg ggcggggcca cgcacaggcc ctgcatggga 1560 ggactcctca ccccaggcct gtggtgctgc agacaaccgt ctcctgtcta cactgcgacc 1620 cagccacaag ctgtggggtc tcagtggcct gggggaaagc agctccactc tcctgccctt 1680 cctggctgcc cctttgggtt ccagccgggg tcacgtccag cctccactgg gaaaccagtg 1740 actgaggcct ggacccagag gtggaccagg catctcctgg ccacctgtga cctgggaaga 1800 agcgagtcag tggcccgttc aacctgctct gcagctgcta taaatagcct ccctgtttcc 1860 aagaggaggt aaggaagtgt ttatcttcta aaaaccagac gtttcctgat gctctgagcg 1920 ttactcagtg ctacagagga gatgcacacg tccccactat gttctgtctt gagaagggga 1980 caagagaaag aggaaaagga gccactgtac tttattttgc acctacagcg tgccttggca 2040 ctgggctaga gaggcacctt cctgcgtgaa tcctgtgcgg caggtcttat tgccataata 2100 agtcacatca aagacactgc tggtcataaa acactgtttt acataccata gggaaaaacg 2160 ctgccaatct taactaagat gctacaactg tacagttcct tccaatcaga gatgttcacg 2220 tgtgaaaaaa aaactgtgct acttacaatc tatgaaagct ggtattatcc cacttggcag 2280 gtaaggaaac tgaggtcctg tgagtgaagt gacctcatga tcacagaaca ggagatggca 2340 gggctgggat tcaaacccgg gagtgtctgc tgccacatcc cacactccca ctgcctggct 2400 ccaagtccca ggaagctcga gactgtgagt tttctccctt gaaactcacc tggagagagt 2460 ccgggcacct gtgcctatgt ggagggttcc agccccagcc aggcccctcc gctgcccaca 2520 ccctgggagg agaagcggcc tcccttccag gctcatctgc tcactgcccg cattctcctg 2580 gcagagctga ggtctgagag atctggactc caacccaagg gccctctctt gttattcagg 2640 ggtgtccaca gttaggaagg gacctggggc cttgtcccac caccttccta ggccccgtga 2700 tcaccacccc ctcaagcggg gccccagccc cctgagcacc ccctcacgtg acccagccct 2760 cggctgttcc aggctcactg cccatggtgt gctcttctgg gccacagcag ccagggctcc 2820 agggcgagga caggggacac ctgaaaacac cccgttgttc atggtcttgt gcccattcat 2880 tcggagactc ctgaaaaact gggctgtttg caaagcaaat ccagctcctt gtcctagcag 2940 gttctcagaa cggggagtcc cctgggatgg agctgctccc ctcacggcag caccacgttt 3000 ccagtccctc gatgccacta atcagcatgg actgtgttca ggacacaggg tgaacttttc 3060 tctgaccccc ggtgctggtc ctgtgccagc acgtagtagt tactcagtag aggtttgctg 3120 agtaaaccag aaatcagatt atgagtgttc aggggtttga taaaacagca ccacataacg 3180 cacacaaaga tactccagaa acatttgctg agtacctagt acgtgtgagg tgctgtgagg 3240 atagagcaga gaggactgtg ccccagctgt gatgctggca gaggtgacac taagagggaa 3300 atgagatatt tggggcagaa tccactgggc tctcttggcc atccgctgcc ttgggtctgt 3360 tgaggtgggt gcccaaaggc tgccttcttg accagaacct gctgtgcgct tcacagaacc 3420 tcctcttcat tggaaatgct gggcacattg cagtcagtga gctgctgcca aaacggcgtt 3480 aagtagaacc cccagaggcc ccgccggttg gtgatcaccc tcaggtcctg ccagggagac 3540 acagtgagga ggttggctaa ttgctgcttt caggccctgg aaatcagtcg ccaaggccca 3600 ggagaacccc ggtgagtccg tccagttgag gcagaggcaa taacctccca ttgctcggcc 3660 ctgcgcctgc cccagtcctg gcagggggca ccggctcagg aacatgcggc ctcctggcat 3720 ttctcggtat ttaactgtct cgctgtctta tccgagtccc taatgaaacg acttgtgtga 3780 caatctgtct gtgccttacg aaagtgtctg tgcacttttt atccttttta aaagcaactt 3840 ttaaaagtgg atggggaggg gggctagcat acgtggtagg gttctagaaa tctgtggtca 3900 tcgctgaaat cctttttgca tcatgttttt tgatgttgga gtgatgaagt gtacatcccc 3960 caccccacac accactacct gtgtacagac cttttaaaac atgtcttctt tttctgattc 4020 aatactgtga cctctccgat acagtctaat ccttggggat ctgtaatcaa ggttttaaaa 4080 cctgggaagt gggttgggaa gggtttgcac tggtcttgag tgttgtgctt ttctgtgttg 4140 tgtgttttga tttttgtctt tttatctgtt ttatattgac ataattttcc tgtttaaaaa 4200 aaatacaact ttggcttgtt aaaa 4224 <210> 257 <211> 2608 <212> DNA <213> Homo sapiens <400> 257 cgcagagcag ttcagttcgc tcactcctcg ccggccgcct ctccttcggg ctctcctcgc 60 gtcactggag ccatggcgtt cgccgagacc tacccggcgg catcctccct gcccaacggc 120 gattgcggcc gccccagggc gcggcccgga ggaaaccggg tgacggtggt gctcggtgcg 180 cagtggggcg acgaaggcaa agggaaggtg gtggacctgc tggcgcagga cgccgacatc 240 gtgtgccgct gccagggagg aaataatgct ggccatacag ttgttgtgga ttctgtggaa 300 tatgattttc atctcttacc cagtggaata attaatccaa atgtcactgc attcattgga 360 aatggtgtgg taattcatct acctggattg tttgaagaag cagagaaaaa tgttcaaaaa 420 ggaaaaggac tagaaggctg ggaaaaaagg cttattatat ctgacagagc tcatattgta 480 tttgattttc atcaagcagc tgatggtatc caggaacaac agagacaaga acaagcagga 540 aaaaatttgg gtacaacaaa aaagggcatt ggcccagttt attcgtccaa agctgctcgg 600 agtggactca ggatgtgcga ccttgtttct gactttgatg gcttctctga gaggtttaaa 660 gttctagcta accaatacaa atctatatac cccactttgg aaatagacat tgaaggtgaa 720 ttacaaaaac tcaagggtta tatggaaaag attaaaccaa tggtgagaga tggagtttat 780 tttctatatg aggccctaca tggaccacca aagaaaatct tggtagaagg tgcaaatgca 840 gcactattag atattgattt tgggacttac ccttttgtaa cctcttcaaa ttgtactgtt 900 ggaggtgttt gtactggttt gggtatgcca cctcaaaatg ttggagaagt gtatggagtt 960 gtgaaagctt atacaactag agttggtatt ggtgcctttc ctacagagca agacaatgaa 1020 attggagaat tattacaaac aaggggtaga gagtttggtg taactactgg aaggaaaaga 1080 agatgtggct ggttggacct cgttttgctc aaatatgctc atatgatcaa tggatttact 1140 gcgttggcac ttaccaagtt ggatattttg gacatgttta cggaaatcaa agttggagtt 1200 gcttacaagt tagatggtga aatcatacct catatcccag caaaccaaga agtcttaaat 1260 aaagttgaag ttcaatataa gactctccca ggatggaaca cagacatatc aaatgcaagg 1320 gcgtttaaag aactacctgt taatgcacaa aactatgttc gatttattga agatgagctt 1380 caaattccag ttaagtggat tggtgttggt aaatccagag aatctatgat tcaactcttt 1440 taatgattgc cagtaatgca agaaacactc cttgagaggg aggggaaaag actttcttaa 1500 atatttcatt tatgacctgc aaattcaaga ataaagacac tgaagtaagt ttgaagccct 1560 acagttgttt ccagtctttt cagatggatg cctactgtgg agattaactt tggcatattc 1620 cagtgtcagc tttctttagc tggaattgcc aaatcatttg ttgctcctgc tgctctcatg 1680 gtgccacgtt tttttttttc aatgtttagt aatagtataa tccatgttgt ttgatatcaa 1740 aagtagaatt gcttttaatg tagtttttct tcattattgt cattgcgtgt tcttaagttt 1800 tacccctatt agatggtaag aacaattaat gcagttttgc acaaatattt ttacattctg 1860 atcattcagt tctgtcattg taatctttgt tgttagaaac aaatgatgaa aacatagggg 1920 ttctgtaaac ttttgtaatg ctatgaattc tgtttaaatt ttgggctgtc tattttctgc 1980 tgaaaccatg caaaattgag ctttggtggg gctgggaggg ggttatgtat tcatgggacc 2040 tttaatttgt acagaacaca gaacttattt ctgtcagtta tttaatacat tgaaaattta 2100 gtgaaatgtt caaagagaat agatgtttcc caaaacaaca atctttatgt taaaaatagt 2160 cattaaaaga tctgttgtaa tatatggtgg atatttttct ttaatttcaa acattacctc 2220 tgaaatgtgt atcttttctt ttttatctta ccattaattt taaatctagt ggattggttt 2280 tcaacatcgt gcctgccgat atgcctacag aatcatctgt aagtgtcaaa atgaacccac 2340 gttgttagcc ataattttga ttatgccttt atttctcctt tcttgaaaaa aaaaaggtgt 2400 tattttgaca attaggcata acattgtttt gtagattatc ttttaatgaa ctattttaaa 2460 tgttaaatta ggtgccactt aaatttattt tattacacca tgaatagctg attaaaagaa 2520 ccaaatattt ctagtaaaaa aaatctatgt cggtgcggag aaagaggtaa tgaaatggca 2580 ggaattcgat atcagcttat ccataccg 2608 <210> 258 <211> 194 <212> DNA <213> Homo sapiens <400> 258 ccgctggcat gtacatgacg ggatatgtgc tgatacagga gaagccaaaa atgtttgcca 60 agggaactga gatcacccat gctgttgtta tcaagaaact ggggattggg tgggcaggaa 120 aaggtgatat ccattctttc tgataactag atggtgctga gaagcttttg aataaaaact 180 ttgctaaatg agaa 194 <210> 259 <211> 4877 <212> DNA <213> Homo sapiens <400> 259 attggcgggc acgccccctc gcccgcggcc ccctccccgc ctctctccac cgcctcctct 60 ggctccccgg tcagagggcc ggagcgagaa gatggcgaag acgtacgatt atctcttcaa 120 gctcctgctg atcggcgact cgggggtagg caagacctgc ctcctgttcc gcttctcaga 180 ggacgccttc aacaccacct tcatctccac catcggaatt gattttaaaa ttagaacgat 240 agaactagat ggaaagaaaa ttaagcttca gatatgggac acagcgggtc aggaaagatt 300 ccgaacaatc acgacagcgt actacagagg agccatgggc attatgctgg tctatgacat 360 cacaaatgaa aaatcctttg acaatattaa aaattggatc agaaacattg aagagcatgc 420 ctcttccgat gtcgaaagaa tgatcctggg taacaaatgt gatatgaatg acaaaagaca 480 agtgtcaaaa gaaagagggg agaagctagc aattgactat gggattaaat tcttggagac 540 aagcgcaaaa tccagtgcaa atgtagaaga ggcatttttt acacttgcac gagatataat 600 gacaaaactc aacagaaaaa tgaatgacag caattcagca ggagcaggtg gaccagtgaa 660 aataacagaa aaccgatcaa agaagaccag tttctttcgt tgctcgctac tttgatgaac 720 tctttctgag agactgcagc acacctagag ggccctttcc tgcttctctg aaagcacagg 780 tcacccagcc tcagaatcac acctcccggc tgctgctgag agcaccactg aacttagacc 840 tctcaacaca gtatgccaag tggattccag cctcatggcc tagcaaaaga acagactccc 900 tttttcaaac atggaagcaa tgaagtggag acacatgcag gacctaactc gttttttcct 960 tgttttatta cctgttgcag aagcggttat ctttcttttt tactttgcac atcagtgtta 1020 gcctttccct atttcagcac aatcttagac tcatatttgc acacttttgt gtcgtgaagt 1080 tctagacaaa tttgtacatg tggcaatgtt aaaagagcat ttacagcaga ggttaatata 1140 ctaaaattaa agggtatttg gtctggttca tatggtcaaa tattactgcc ttggtagcat 1200 ttatttaagg gctttttctt aaataagaat cattaaagtc attaaaaaaa tttactgaaa 1260 tgcccatctt gtcatcaaag gccacaattt ctttatttct tcagattaag agctttgcct 1320 catccccgac ctgttttcca gagtctgggt agctgaatga atcactttaa aatgattacc 1380 tctgcctaat ctatagaaac tgcatttgga aatcaccata atctcatttt tccctggggt 1440 ttgtatttgc tattctttcc catgtttgac ttaagtgtaa tcactcttaa gtaatatttg 1500 aacattatta tctgtttcta tttgtgaact tcttgagctg aaattttacg tgggctgaga 1560 gatataccat ttagggtttt agtgcagcat ctaactgtga ttctgtcaat aaggatatgt 1620 aatatatttt ttcttaggtt cactccttag ctggctggtt tagttgtaat accaaattcc 1680 taccataatc cctgtctaca aaagttaggt ttagatttta gtttgcggaa accttcccta 1740 tatagagaca gattaacttg ttgatataaa tttaatagag ctagctcttg gtaatggtga 1800 aaataatgag ttttggttgg ttttatttgg cagatgtttt tagaaataaa agtacttaga 1860 cctagtgcag cctctaggaa aagtcttgcc ttttcattag agaaaacagg accaaggttt 1920 cagttttcaa acagctgttg ttgaatgtgt agaacccagt tccatctgtt ttggttcatt 1980 gttacagaac ttagtccagt catttgggct aaagccaacc aaaagcttag ttgcctttct 2040 caacaaacac tggtactggt atacttttgt agatgaaacc atcacaaggt atttagtgtt 2100 aacttgtgtg ccaaattcag atcactatgt cgttgttgct ctagccttca gtgtcataac 2160 acagggggga taaaacagag gggatgaggg aaatgaattc tgttaataat tattcttcct 2220 ggtatgcctg ttttgcttca caaaggctac tatcatgctg gatagataag aacaggagat 2280 ggcagtggaa agggattgct tgttaccaca gagaattctc ttcaaattaa gatatgtcat 2340 tagaatgctt ggaccagtca atcttttgta cttatttgaa aatataggaa caatttagca 2400 gctgcaaata tgcccaagct atttttaata gatatactaa acttattgtt gacaaatttc 2460 agcctcctta attttttttt tttttggtaa ttacctatag gcttaaaagt cattcgttgc 2520 tgttctagta taattagtag ttccgtgatt gaaagtttat ggtaattcta ctatcttcaa 2580 attagataca ttttcaaaag gaaaagataa ttttttagaa acatcttaat attcactatt 2640 tcctgaaaaa atccaagcag ttaacgcttt ctggatggta acaaagtacc ttctaaaaga 2700 taagtgctat gacaccatgt atgaatgtaa ttctcttagt aatttacctc tgactatttg 2760 gtgtcttaac gctttggttt atataatctc aggggttgtc tgcaaaccaa aactgacata 2820 ttctgtggtt agcttttatt actttttttt ttaacagaat gctttgcttt ggttatattt 2880 cttctttctt cttttgtctt atatggatta ataactagtc tccatgaact tcacttgaaa 2940 gagcctgtaa aagttagatg agtctaaaag tgctctttga agtagcagca aattgggagt 3000 atatgctctg ttatatagaa ataaattgtc cttgctattt tcttacattt agctttgcta 3060 gattgtatat acattgagct aagaccttag gaaattcact ttctgcatga taaaatgacc 3120 caataaatat tccactttgc ttaataatgt acatacagtg cattattttt tctatttgta 3180 gatgaattta atgacagata attgtctgtt ccccgctgaa actgaagaaa tctagttttt 3240 ttgtgaacat ttttgtggtc ttatggataa ggtacatgaa gatttttgca gcagtattag 3300 tggttcagtg gctgcacttt attaatcagt gtgttaattt ttgacagtga ttggactaga 3360 ccttttcaaa tagagtctga gggtatcaga cagtgaaaat gtgctgtaac taagtagcat 3420 gtaaatcagt tgattgtaaa acgtttcgct gggaacttat tttagctata ttttacttca 3480 gacagattat gatacaataa tctacctgtg catcagttag taggtgctgc agggtttctt 3540 actatttaca gaaacatttt gtgcagtctt tgttataaat tttcagaaga ctatactctt 3600 tactttgaag gtctattttt taattatacc tcatttagct aactagtatt ctaatacctg 3660 gtagaaaaac agtgagccag cctttaagca tctaacaaaa tttagactct ttgttttgtt 3720 ttgaactgaa gacatcattg ggaaaggtag gaaatattag tttaggatag agcatacatg 3780 tcatatccag tagcataaaa aaagtattat ctccctgtct ccattaataa atttagctgt 3840 gcaatatagg tgcgtttttg cagaagtttc tagtaagaga ttataactcc attttacagg 3900 ttctgaatgc tcagagtcta tattaaggct tataaagttt ttcctgtgat cagtaagtga 3960 cacatttaag cagacattct tttcaagttc atgacttaga ttcctttaca aatttagttc 4020 tcaatcttta aaaaccacat ttcattatgt tggttaatta ttataaattt taagcactca 4080 tttctgcaat caggtttctc agaannnnnn nnnnnnnnnn nnnggggnca ttcctttttc 4140 cttgttacat ccaagggggg cacaggggtg ggtggaaagg aatgtctaaa aatgaaatcc 4200 cttgatatag agggacctag acggacagga tatgctaaaa taatttcaaa ttctagcaca 4260 attttagagt agaataagtc atttttttag actaataaaa ttaatggctg tcatgttcac 4320 tctgaaaaaa atctaaatga ctgaaatgta cagaaataaa aattagcaaa caattattct 4380 agggatattt tcagatttta cttcatttct tgaaatgcgt gtgccatatg caattgcatt 4440 tcttgtgcca agaaactaat agaacttatt tcactttacc tttttttaaa atgtgaattt 4500 agttattata gttcaatttt atggccttac agatggcttt tattttgttt gcagctgaca 4560 ctgcagttcc tttcatgcaa aataccataa actgtttgat gaaaatcatg cccctaatgg 4620 aaactctcta gtttttccat ataactatcc tactgtacat gtttaaacat attttatttt 4680 tgctccaatg gcttaatgtg aaaagctcct gcagataagt ggacctgtca tgtggttaat 4740 cttgtttaag ccaattcatt aactgtgtac tgatactgat gctatgtttt ttttaaatgg 4800 attttattcc aggtgaactt tttttttata ataatgttcg tctaaaataa aaactacata 4860 atgaaaatga aaatgct 4877 <210> 260 <211> 4635 <212> DNA <213> Homo sapiens <400> 260 gcggccgcgg gagcccgcgc cccgcccgcc gcgcctctgc cgggacccac ccgcagcgga 60 gggctgagcc cgccggcggc tccccggagc tcacccacct ccgcgcgccg gagcgcaggc 120 aaaaggggag gaaaggctcc tctctttagt caccactctc gccctctcca agaatttgtt 180 taacaaagcg ctgaggaaag agaacgtctt cttgaattct ttagtagggg cggagtctgc 240 tgctgccctg cgctgccacc tcggctacac tgccctccgc gacgacccct gaccagccgg 300 ggtcacgtcc gggagacggg atcatgaagc gctcggtagc cgtctggctc ttggtcgggc 360 tcagcctcgg tgtcccccag ttcggcaaag gtgatatttg tgatcccaat ccatgtgaaa 420 atggaggtat ctgtttgcca ggattggctg atggttcctt ttcctgtgag tgtccagatg 480 gcttcacaga ccccaactgt tctagtgttg tggaggttgc atcagatgaa gaagaaccaa 540 cttcagcagg tccctgcact cctaatccat gccataatgg aggaacctgt gaaataagtg 600 aagcataccg aggggataca ttcataggct atgtttgtaa atgtccccga ggatttaatg 660 ggattcactg tcagcacaac ataaatgaat gcgaagttga gccttgcaaa aatggtggaa 720 tatgtacaga tcttgttgct aactattcct gtgagtgccc aggcgaattt atgggaagaa 780 attgtcaata caaatgctca ggcccactgg gaattgaagg tggaattata tcaaaccagc 840 aaatcacagc ttcctctact caccgagctc tttttggact ccaaaaatgg tatccctact 900 atgcacgtct taataagaag gggcttataa atgcgtggac agctgcagaa aatgacagat 960 ggccgtggat tcagataaat ttgcaaagga aaatgagagt tactggtgtg attacccaag 1020 gagccaagag gattggaagc ccagagtata taaaatccta caaaattgcc tacagtaatg 1080 atggaaagac ttgggcaatg tacaaagtga aaggcaccaa tgaagacatg gtgtttcgtg 1140 gaaacattga taacaacact ccatatgcta actctttcac accccccata aaagctcagt 1200 atgtaagact ctatccccaa gtttgtcgaa gacattgcac tttgcgaatg gaacttcttg 1260 gctgtgaact gtcgggttgt tctgagcctc tgggtatgaa atcaggacat atacaagact 1320 atcagatcac tgcctccagc atcttcagaa cgctcaacat ggacatgttc acttgggaac 1380 caaggaaagc tcggctggac aagcaaggca aagtgaatgc ctggacctct ggccacaatg 1440 accagtcaca atggttacag gtggatcttc ttgttccaac caaagtgact ggcatcatta 1500 cacaaggagc taaagatttt ggtcatgtac agtttgttgg ctcctacaaa ctggcttaca 1560 gcaatgatgg agaacactgg actgtatacc aggatgaaaa gcaaagaaaa gataaggttt 1620 tccagggaaa ttttgacaat gacactcaca gaaaaaatgt catcgaccct cccatctatg 1680 cacgacacat aagaatcctt ccttggtcct ggtacgggag gatcacattg cggtcagagc 1740 tgctgggctg cacagaggag gaatgagggg aggctacatt tcacaaccct cttccctatt 1800 tccctaaaag tatctccatg gaatgaactg tgcaaaatct gtaggaaact gaatggtttt 1860 tttttttttt tcatgaaaaa gtgctcaaat tatggtaggc aactaacggt gtttttaagg 1920 gggtctaagc ctgccttttc aatgatttaa tttgatttta ttttatccgt caaatctctt 1980 aagtaacaac acattaagtg tgaattactt ttctctcatt gtttcctgaa ttattcgcat 2040 tggtagaaat atattaggga aagaaagtag ccttcttttt atagcaagag taaaaaagtc 2100 tcaaagtcat caaataagag caagagttga tagagctttt acaatcaata ctcacctaat 2160 tctgataaaa ggaatactgc aatgttagca ataagttttt ttcttctgta atgactctac 2220 gttatcctgt ttccctgtgc ctaccaaaca ctgtcaatgt ttattacaaa attttaaaga 2280 agaatatgta acatgcagta ctgatattat aattctcatt ttactttcat tatttctaat 2340 aagagattat gtgacttctt tttcttttag ttctattcta cattcttaat attgtatatt 2400 acctgaataa ttcaattttt ttctaattga atttcctatt agttgactaa aagaagtgtc 2460 atgtttactc atatatgtag aacatgactg cctatcagta gattgatctg tatttaatat 2520 tcgttaatta aatctgcagt tttatttttg aaggaagcca taactattta atttccaaat 2580 aattgcttca taaagaatcc catactctca gtttgcacaa aagaacaaaa aatatatatg 2640 tctctttaaa tttaaatctt catttagatg gtaattacat atccttatat ttactttaaa 2700 aaatcggctt atttgtttat tttataaaaa atttagcaaa gaaatattaa tatagtgctg 2760 catagtttgg ccaagcatac tcatcatttc tttgttcagc tccacatttc ctgtgaaact 2820 aacatcttat tgagatttga aactggtggt agtttcccag gaaggcacag gtggagttat 2880 ttgtgagaag caaagtgttt actaatgaca aagtagtaaa ccattttcaa gatgaaaact 2940 gatttctatt tattttgctt caaaggtcct gaaaaaataa gcaattatca taacaatttg 3000 ttattgatac tggaggtttc attgacatgt ctctcaaatt aaagctcaca ctgcctccat 3060 aaaagtcttc aacatctaat ttataagctt tacaagtatt tattttataa ggcttagaca 3120 gaattattgg agttttaaat taagtgtatt ggaaaagaaa ggatggtatg tgtatgaaat 3180 gttaagatcc tacgcaacac tgctattttt ttcctttaat atttgtgctg cataacaaaa 3240 gccactagac tgttactgtc ttgtctgtcc atgtgttaac agcatttctt aatgatgtat 3300 atatggagtg gtcttcaatc atagtgaaga atttaaagag aaagtcaatt gtattggcat 3360 ttttaataag aacaaaatta gttcgtctaa ggggactggc tggccacata tttgttcctt 3420 gcccatatgc tttctacttc ttgttcttat tatgaaatta tgaatttgaa gcctctgaaa 3480 tggtgatcag ttttcaacat ctttcaaaaa caaaattact atttcctcca tattgccttt 3540 tttagataac tttaaagtta ggattttaaa atatttgtaa ctggctaaat tttaaagtcg 3600 tgacaaataa ttacttaggt tcagaaatat acacacactt actctttagc cagtttcttt 3660 caaggtttac tgtcccatca gatatctagc cattttcctt tgcaaattac ataccttctt 3720 aagagtgtat ttttaagatt attacttatg ctttatgatg atatagtttt tcaaaattat 3780 ttatagcttc atatgatgtt ttgtaatttt ttctattgat acctgtttta aaaatatttt 3840 ccaaggaagt tgattaaaat tatatttgtt accttttaga aaaagcattg aaatgagttt 3900 ctcttgcttt ttcattttcc ctctgcttta tatgctcttc gcaatacatc atgtccaacg 3960 ggatacctat tgttctcatg acacccaaaa ttgatgagag caaaggggtc gcaccatatg 4020 gaaatgttga aaactattgt aaagtagtat tatgaagtag cttttgtgtc attcatgtcg 4080 atgacatgaa agtgaagtaa atttattcta tgtaaattca cactaaaacc agtacagtac 4140 cataagtaga atacatgtaa gaatcaccta gtcttcacta tattgagtaa atataacatg 4200 ctaattttac aattaatgaa actaaacttt taaacatctc cattatatct acatcctttt 4260 gaaggtattt atcatagttg ccaattttaa ttttaggatt gactttctct ttctgaatga 4320 cttcataaag tttggtgtga attttgaaga cttgggttac taatgattgt atctttgcta 4380 gtcaacaact tatgaaatat actcaatgcg tctgatgtgt cattaagtgc agaaataact 4440 aagacacaaa taacctttgc aaaccttcaa gctgtgtaat attccaatgt tgtttttttc 4500 tttgtatata tacttatatc acgtaggatg taaaaccagt atgaccttgt ctagtctcca 4560 aacttaaaat aaacttttga aaagctggga ttcttttgaa gcagttgtaa ttaaacacat 4620 ttataagaat acaaa 4635 <210> 261 <211> 77 <212> PRT <213> Homo sapiens <400> 261 Met Asp Leu Val Lys Asn His Leu Met Tyr Ala Val Arg Glu Glu Val 1 5 10 15 Glu Ile Leu Lys Glu Gln Ile Arg Glu Leu Val Glu Lys Asn Ser Gln 20 25 30 Leu Glu Arg Glu Asn Thr Leu Leu Lys Thr Leu Ala Ser Pro Glu Gln 35 40 45 Leu Glu Lys Phe Gln Ser Cys Leu Ser Pro Glu Glu Pro Ala Pro Glu 50 55 60 Ser Pro Gln Val Pro Glu Ala Pro Gly Gly Ser Ala Val 65 70 75 <210> 262 <211> 114 <212> PRT <213> Homo sapiens <400> 262 Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 1 5 10 15 Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Thr Pro Pro Gly 20 25 30 Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Thr Glu Leu Arg 35 40 45 Cys Thr Cys Leu Arg Val Thr Leu Arg Val Asn Pro Lys Thr Ile Gly 50 55 60 Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 65 70 75 80 Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 85 90 95 Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Ser Gly Asn Lys 100 105 110 Lys Asn <210> 263 <211> 228 <212> PRT <213> Homo sapiens <400> 263 Met Ala Ser Thr Ala Ser Glu Ile Ile Ala Phe Met Val Ser Ile Ser 1 5 10 15 Gly Trp Val Leu Val Ser Ser Thr Leu Pro Thr Asp Tyr Trp Lys Val 20 25 30 Ser Thr Ile Asp Gly Thr Val Ile Thr Thr Ala Thr Tyr Trp Ala Asn 35 40 45 Leu Trp Lys Ala Cys Val Thr Asp Ser Thr Gly Val Ser Asn Cys Lys 50 55 60 Asp Phe Pro Ser Met Leu Ala Leu Asp Gly Tyr Ile Gln Ala Cys Arg 65 70 75 80 Gly Leu Met Ile Ala Ala Val Ser Leu Gly Phe Phe Gly Ser Ile Phe 85 90 95 Ala Leu Phe Gly Met Lys Cys Thr Lys Val Gly Gly Ser Asp Lys Ala 100 105 110 Lys Ala Lys Ile Ala Cys Leu Ala Gly Ile Val Phe Ile Leu Ser Gly 115 120 125 Leu Cys Ser Met Thr Gly Cys Ser Leu Tyr Ala Asn Lys Ile Thr Thr 130 135 140 Glu Phe Phe Asp Pro Leu Phe Val Glu Gln Lys Tyr Glu Leu Gly Ala 145 150 155 160 Ala Leu Phe Ile Gly Trp Ala Gly Ala Ser Leu Cys Ile Ile Gly Gly 165 170 175 Val Ile Phe Cys Phe Ser Ile Ser Asp Asn Asn Lys Thr Pro Arg Tyr 180 185 190 Thr Tyr Asn Gly Ala Thr Ser Val Met Ser Ser Arg Thr Lys Tyr His 195 200 205 Gly Gly Glu Asp Phe Lys Thr Thr Asn Pro Ser Lys Gln Phe Asp Lys 210 215 220 Asn Ala Tyr Val 225 <210> 264 <211> 152 <212> PRT <213> Homo sapiens <400> 264 Ser Leu Thr Gly Asn Ser Leu Gly Arg Asn Asp Leu Ala Asp Gly Val 1 5 10 15 Asn Ser Gly Gln Gly Leu Gly Ile Glu Ile Ile Gly Thr Leu Gln Leu 20 25 30 Val Leu Cys Val Leu Ala Thr Thr Asp Arg Arg Arg Arg Asp Leu Gly 35 40 45 Gly Ser Ala Pro Leu Ala Ile Gly Leu Ser Val Ala Leu Gly His Leu 50 55 60 Leu Ala Ile Asp Tyr Thr Gly Cys Gly Ile Asn Pro Ala Arg Ser Phe 65 70 75 80 Gly Ser Ala Val Ile Thr His Asn Phe Ser Asn His Trp Ile Phe Trp 85 90 95 Val Gly Pro Phe Ile Gly Gly Ala Leu Ala Val Leu Ile Tyr Asp Phe 100 105 110 Ile Leu Ala Pro Arg Ser Ser Asp Leu Thr Asp Arg Val Lys Val Trp 115 120 125 Thr Ser Gly Gln Val Glu Glu Tyr Asp Leu Asp Ala Asp Asp Ile Asn 130 135 140 Ser Arg Val Glu Met Lys Pro Lys 145 150 <210> 265 <211> 2074 <212> PRT <213> Homo sapiens <400> 265 Trp Ala Thr Cys Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser 1 5 10 15 Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro His Met 20 25 30 Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu 35 40 45 Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly 50 55 60 Ser Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn 65 70 75 80 Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu 85 90 95 Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys 100 105 110 Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys 115 120 125 Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr 130 135 140 Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly 145 150 155 160 Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser 165 170 175 His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly 180 185 190 Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met 195 200 205 Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile 210 215 220 Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser 225 230 235 240 Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu 245 250 255 Cys Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn 260 265 270 Leu Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val 275 280 285 Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser Pro 290 295 300 Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp Ser Ser 305 310 315 320 Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys Leu Val 325 330 335 Asp Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr Cys Ser Cys 340 345 350 Glu Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile Ala Ala Tyr 355 360 365 Ala His Val Cys Ala Gln His Gly Lys Val Val Thr Trp Arg Thr Ala 370 375 380 Thr Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg Glu Asn Gly 385 390 395 400 Tyr Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val 405 410 415 Thr Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln Cys Val Glu 420 425 430 Gly Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu 435 440 445 Gln Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly 450 455 460 Arg Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro 465 470 475 480 Glu His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu 485 490 495 Ala Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro 500 505 510 Val Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu 515 520 525 His Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp 530 535 540 Gly Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe 545 550 555 560 Val Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg 565 570 575 Val Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu 580 585 590 Lys Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val 595 600 605 Lys Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr 610 615 620 Thr Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg 625 630 635 640 Ile Ala Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg 645 650 655 Asn Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val 660 665 670 Ile Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu 675 680 685 Ile Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val 690 695 700 Asp Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp 705 710 715 720 Leu Ala Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro Asp Met Ala Gln 725 730 735 Val Thr Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu Gly Pro Lys 740 745 750 Arg Asn Ser Met Val Leu Asp Val Ala Phe Val Leu Glu Gly Ser Asp 755 760 765 Lys Ile Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe Met Glu Glu 770 775 780 Val Ile Gln Arg Met Asp Val Gly Gln Asp Ser Ile His Val Thr Val 785 790 795 800 Leu Gln Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe Ser Glu Ala 805 810 815 Gln Ser Lys Gly Asp Ile Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln 820 825 830 Gly Gly Asn Arg Thr Asn Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp 835 840 845 His Ser Phe Leu Val Ser Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu 850 855 860 Val Tyr Met Val Thr Gly Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu 865 870 875 880 Pro Gly Asp Ile Gln Val Val Pro Ile Gly Val Gly Pro Asn Ala Asn 885 890 895 Val Gln Glu Leu Glu Arg Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile 900 905 910 Gln Asp Phe Glu Thr Leu Pro Arg Glu Ala Pro Asp Leu Val Leu Gln 915 920 925 Arg Cys Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala 930 935 940 Pro Asp Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser 945 950 955 960 Ser Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys 965 970 975 Ala Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser 980 985 990 Val Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val 995 1000 1005 Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg 1010 1015 1020 Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg 1025 1030 1035 1040 Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala 1045 1050 1055 Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala 1060 1065 1070 Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile 1075 1080 1085 Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala 1090 1095 1100 Gly Asp Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr 1105 1110 1115 1120 Met Val Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe 1125 1130 1135 Val Arg Ile Cys Met Asp Glu Asp Gly Asn Glu Lys Arg Pro Gly Asp 1140 1145 1150 Val Trp Thr Leu Pro Asp Gln Cys His Thr Val Thr Cys Gln Pro Asp 1155 1160 1165 Gly Gln Thr Leu Leu Lys Ser His Arg Val Asn Cys Asp Arg Gly Leu 1170 1175 1180 Arg Pro Ser Cys Pro Asn Ser Gln Ser Pro Val Lys Val Glu Glu Thr 1185 1190 1195 1200 Cys Gly Cys Arg Trp Thr Cys Pro Cys Val Cys Thr Gly Ser Ser Thr 1205 1210 1215 Arg His Ile Val Thr Phe Asp Gly Gln Asn Phe Lys Leu Thr Gly Ser 1220 1225 1230 Cys Ser Tyr Val Leu Phe Gln Asn Lys Glu Gln Asp Leu Glu Val Ile 1235 1240 1245 Leu His Asn Gly Ala Cys Ser Pro Gly Ala Arg Gln Gly Cys Met Lys 1250 1255 1260 Ser Ile Glu Val Lys His Ser Ala Leu Ser Val Glu Leu His Ser Asp 1265 1270 1275 1280 Met Glu Val Thr Val Asn Gly Arg Leu Val Ser Val Pro Tyr Val Gly 1285 1290 1295 Gly Asn Met Glu Val Asn Val Tyr Gly Ala Ile Met His Glu Val Arg 1300 1305 1310 Phe Asn His Leu Gly His Ile Phe Thr Phe Thr Pro Gln Asn Asn Glu 1315 1320 1325 Phe Gln Leu Gln Leu Ser Pro Lys Thr Phe Ala Ser Lys Thr Tyr Gly 1330 1335 1340 Leu Cys Gly Ile Cys Asp Glu Asn Gly Ala Asn Asp Phe Met Leu Arg 1345 1350 1355 1360 Asp Gly Thr Val Thr Thr Asp Trp Lys Thr Leu Val Gln Glu Trp Thr 1365 1370 1375 Val Gln Arg Pro Gly Gln Thr Cys Gln Pro Ile Leu Glu Glu Gln Cys 1380 1385 1390 Leu Val Pro Asp Ser Ser His Cys Gln Val Leu Leu Leu Pro Leu Phe 1395 1400 1405 Ala Glu Cys His Lys Val Leu Ala Pro Ala Thr Phe Tyr Ala Ile Cys 1410 1415 1420 Gln Gln Asp Ser Ser His Gln Glu Gln Val Cys Glu Val Ile Ala Ser 1425 1430 1435 1440 Tyr Ala His Leu Cys Arg Thr Asn Gly Val Cys Val Asp Trp Arg Thr 1445 1450 1455 Pro Asp Phe Cys Ala Met Ser Cys Pro Pro Ser Leu Val Tyr Asn His 1460 1465 1470 Cys Glu His Gly Cys Pro Arg His Cys Asp Gly Asn Val Ser Ser Cys 1475 1480 1485 Gly Asp His Pro Ser Glu Gly Cys Phe Cys Pro Pro Asp Lys Val Met 1490 1495 1500 Leu Glu Gly Ser Cys Val Pro Glu Glu Ala Cys Thr Gln Cys Ile Gly 1505 1510 1515 1520 Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala Trp Val Pro Asp His 1525 1530 1535 Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly Arg Lys Val Asn Cys 1540 1545 1550 Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro Thr Cys Gly Leu Cys 1555 1560 1565 Glu Val Ala Arg Leu Arg Gln Asn Ala Asp Gln Cys Cys Pro Glu Tyr 1570 1575 1580 Glu Cys Val Cys Asp Pro Val Ser Cys Asp Leu Pro Pro Val Pro His 1585 1590 1595 1600 Cys Glu Arg Gly Leu Gln Pro Thr Leu Thr Asn Pro Gly Glu Cys Arg 1605 1610 1615 Pro Asn Phe Thr Cys Ala Cys Arg Lys Glu Glu Cys Lys Arg Val Ser 1620 1625 1630 Pro Pro Ser Cys Pro Pro His Arg Leu Pro Thr Leu Arg Lys Thr Gln 1635 1640 1645 Cys Cys Asp Glu Tyr Glu Cys Ala Cys Asn Cys Val Asn Ser Thr Val 1650 1655 1660 Ser Cys Pro Leu Gly Tyr Leu Ala Ser Thr Ala Thr Asn Asp Cys Gly 1665 1670 1675 1680 Cys Thr Thr Thr Thr Cys Leu Pro Asp Lys Val Cys Val His Arg Ser 1685 1690 1695 Thr Ile Tyr Pro Val Gly Gln Phe Trp Glu Glu Gly Cys Asp Val Cys 1700 1705 1710 Thr Cys Thr Asp Met Glu Asp Ala Val Met Gly Leu Arg Val Ala Gln 1715 1720 1725 Cys Ser Gln Lys Pro Cys Glu Asp Ser Cys Arg Ser Gly Phe Thr Tyr 1730 1735 1740 Val Leu His Glu Gly Glu Cys Cys Gly Arg Cys Leu Pro Ser Ala Cys 1745 1750 1755 1760 Glu Val Val Thr Gly Ser Pro Arg Gly Asp Ser Gln Ser Ser Trp Lys 1765 1770 1775 Ser Val Gly Ser Gln Trp Ala Ser Pro Glu Asn Pro Cys Leu Ile Asn 1780 1785 1790 Glu Cys Val Arg Val Lys Glu Glu Val Phe Ile Gln Gln Arg Asn Val 1795 1800 1805 Ser Cys Pro Gln Leu Glu Val Pro Val Cys Pro Ser Gly Phe Gln Leu 1810 1815 1820 Ser Cys Lys Thr Ser Ala Cys Cys Pro Ser Cys Arg Cys Glu Arg Met 1825 1830 1835 1840 Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly Pro Gly Lys Thr Val 1845 1850 1855 Met Ile Asp Val Cys Thr Thr Cys Arg Cys Met Val Gln Val Gly Val 1860 1865 1870 Ile Ser Gly Phe Lys Leu Glu Cys Arg Lys Thr Thr Cys Asn Pro Cys 1875 1880 1885 Pro Leu Gly Tyr Lys Glu Glu Asn Asn Thr Gly Glu Cys Cys Gly Arg 1890 1895 1900 Cys Leu Pro Thr Ala Cys Thr Ile Gln Leu Arg Gly Gly Gln Ile Met 1905 1910 1915 1920 Thr Leu Lys Arg Asp Glu Thr Leu Gln Asp Gly Cys Asp Thr His Phe 1925 1930 1935 Cys Lys Val Asn Glu Arg Gly Glu Tyr Phe Trp Glu Lys Arg Val Thr 1940 1945 1950 Gly Cys Pro Pro Phe Asp Glu His Lys Cys Leu Ala Glu Gly Gly Lys 1955 1960 1965 Ile Met Lys Ile Pro Gly Thr Cys Cys Asp Thr Cys Glu Glu Pro Glu 1970 1975 1980 Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val Gly Ser Cys 1985 1990 1995 2000 Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly Lys Cys Ala 2005 2010 2015 Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val Gln Asp Gln Cys 2020 2025 2030 Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met Gln Val Ala Leu His 2035 2040 2045 Cys Thr Asn Gly Ser Val Val Tyr His Glu Val Leu Asn Ala Met Glu 2050 2055 2060 Cys Lys Cys Ser Pro Arg Lys Cys Ser Lys 2065 2070 <210> 266 <211> 300 <212> PRT <213> Homo sapiens <400> 266 Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 1 5 10 15 Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 20 25 30 Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 35 40 45 Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser 50 55 60 Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 65 70 75 80 Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 85 90 95 Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 100 105 110 Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 115 120 125 Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 130 135 140 Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 145 150 155 160 Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 165 170 175 Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 180 185 190 Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 195 200 205 Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 210 215 220 Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 225 230 235 240 Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 245 250 255 Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 260 265 270 Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 275 280 285 Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 290 295 300 <210> 267 <211> 316 <212> PRT <213> Homo sapiens <400> 267 Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 1 5 10 15 Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 20 25 30 Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 35 40 45 Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 50 55 60 Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 65 70 75 80 Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 85 90 95 Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 100 105 110 Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 115 120 125 Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 130 135 140 Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 145 150 155 160 Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 165 170 175 Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 180 185 190 Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 195 200 205 Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 210 215 220 Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 225 230 235 240 His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 245 250 255 Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 260 265 270 Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 275 280 285 Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 290 295 300 Ser His Leu Glu Asp Tyr Pro Phe Asp Ala Glu Tyr 305 310 315 <210> 268 <211> 344 <212> PRT <213> Homo sapiens <400> 268 Met Ser Ala Leu Ala Ala Arg Leu Leu Gln Pro Ala His Ser Cys Ser 1 5 10 15 Leu Arg Leu Arg Pro Phe His Leu Ala Ala Val Arg Asn Glu Ala Val 20 25 30 Val Ile Ser Gly Arg Lys Leu Ala Gln Gln Ile Lys Gln Glu Val Arg 35 40 45 Gln Glu Val Glu Glu Trp Val Ala Ser Gly Asn Lys Arg Pro His Leu 50 55 60 Ser Val Ile Leu Val Gly Glu Asn Pro Ala Ser His Ser Tyr Val Leu 65 70 75 80 Asn Lys Thr Arg Ala Ala Ala Val Val Gly Ile Asn Ser Glu Thr Ile 85 90 95 Met Lys Pro Ala Ser Ile Ser Glu Glu Glu Leu Leu Asn Leu Ile Asn 100 105 110 Lys Leu Asn Asn Asp Asp Asn Val Asp Gly Leu Leu Val Gln Leu Pro 115 120 125 Leu Pro Glu His Ile Asp Glu Arg Arg Ile Cys Asn Ala Val Ser Pro 130 135 140 Asp Lys Asp Val Asp Gly Phe His Val Ile Asn Val Gly Arg Met Cys 145 150 155 160 Leu Asp Gln Tyr Ser Met Leu Pro Ala Thr Pro Trp Gly Val Trp Glu 165 170 175 Ile Ile Lys Arg Thr Gly Ile Pro Thr Leu Gly Lys Asn Val Val Val 180 185 190 Ala Gly Arg Ser Lys Asn Val Gly Met Pro Ile Ala Met Leu Leu His 195 200 205 Thr Asp Gly Ala His Glu Arg Pro Gly Gly Asp Ala Thr Val Thr Ile 210 215 220 Ser His Arg Tyr Thr Pro Lys Glu Gln Leu Lys Lys His Thr Ile Leu 225 230 235 240 Ala Asp Ile Val Ile Ser Ala Ala Gly Ile Pro Asn Leu Ile Thr Ala 245 250 255 Asp Met Ile Lys Glu Gly Ala Ala Val Ile Asp Val Gly Ile Asn Arg 260 265 270 Val His Asp Pro Val Thr Ala Lys Pro Lys Leu Val Gly Asp Val Asp 275 280 285 Phe Glu Gly Val Arg Gln Lys Ala Gly Tyr Ile Thr Pro Val Pro Gly 290 295 300 Gly Val Gly Pro Met Thr Val Ala Met Leu Met Lys Asn Thr Ile Ile 305 310 315 320 Ala Ala Lys Lys Val Leu Arg Leu Glu Glu Arg Glu Val Leu Lys Ser 325 330 335 Lys Glu Leu Gly Val Ala Thr Asn 340 <210> 269 <211> 300 <212> PRT <213> Homo sapiens <400> 269 Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 1 5 10 15 Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 20 25 30 Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 35 40 45 Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser 50 55 60 Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 65 70 75 80 Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 85 90 95 Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 100 105 110 Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 115 120 125 Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 130 135 140 Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 145 150 155 160 Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 165 170 175 Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 180 185 190 Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 195 200 205 Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 210 215 220 Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 225 230 235 240 Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 245 250 255 Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 260 265 270 Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 275 280 285 Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 290 295 300 <210> 270 <211> 314 <212> PRT <213> Homo sapiens <400> 270 Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 1 5 10 15 Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 20 25 30 Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 35 40 45 Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 50 55 60 Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 65 70 75 80 Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 85 90 95 Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 100 105 110 Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 115 120 125 Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 130 135 140 Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 145 150 155 160 Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 165 170 175 Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 180 185 190 Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 195 200 205 Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 210 215 220 Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 225 230 235 240 Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 245 250 255 Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 260 265 270 Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 275 280 285 Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 290 295 300 Met Gly Glu Met His Arg Glu Leu Asn Ala 305 310 <210> 271 <211> 134 <212> PRT <213> Homo sapiens <400> 271 Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 1 5 10 15 Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 20 25 30 Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 35 40 45 Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 50 55 60 Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 65 70 75 80 Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro 85 90 95 Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr 100 105 110 Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Arg Ser 115 120 125 Gln Thr Pro Lys Gly Pro 130 <210> 272 <211> 199 <212> PRT <213> Homo sapiens <400> 272 Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 1 5 10 15 Glu Ser Gly Gln Glu Asn Asp Ala Thr Ser Pro His Phe Ser Thr Arg 20 25 30 His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 35 40 45 Val Phe Ile Thr Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 50 55 60 Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Ser Asp Ser 65 70 75 80 His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 85 90 95 Tyr Phe Ile Ser Thr Val Lys Arg Ser Trp Thr Ser Ala Gln Asn Ala 100 105 110 Cys Ser Glu His Gly Ala Thr Leu Ala Val Ile Asp Ser Glu Lys Asp 115 120 125 Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 130 135 140 Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 145 150 155 160 Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys Val Phe Leu 165 170 175 Lys Asn Thr Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 180 185 190 Ile Cys Asn Lys Pro Tyr Lys 195 <210> 273 <211> 664 <212> PRT <213> Homo sapiens <400> 273 Met Lys Thr Gly Pro Phe Phe Leu Cys Leu Leu Gly Thr Ala Ala Ala 1 5 10 15 Ile Pro Thr Asn Ala Arg Leu Leu Ser Asp His Ser Lys Pro Thr Ala 20 25 30 Glu Thr Val Ala Pro Asp Asn Thr Ala Ile Pro Ser Leu Trp Ala Glu 35 40 45 Ala Glu Glu Asn Glu Lys Glu Thr Ala Val Ser Thr Glu Asp Asp Ser 50 55 60 His His Lys Ala Glu Lys Ser Ser Val Leu Lys Ser Lys Glu Glu Ser 65 70 75 80 His Glu Gln Ser Ala Glu Gln Gly Lys Ser Ser Ser Gln Glu Leu Gly 85 90 95 Leu Lys Asp Gln Glu Asp Ser Asp Gly His Leu Ser Val Asn Leu Glu 100 105 110 Tyr Ala Pro Thr Glu Gly Thr Leu Asp Ile Lys Glu Asp Met Ile Glu 115 120 125 Pro Gln Glu Lys Lys Leu Ser Glu Asn Thr Asp Phe Leu Ala Pro Gly 130 135 140 Val Ser Ser Phe Thr Asp Ser Asn Gln Gln Glu Ser Ile Thr Lys Arg 145 150 155 160 Glu Glu Asn Gln Glu Gln Pro Arg Asn Tyr Ser His His Gln Leu Asn 165 170 175 Arg Ser Ser Lys His Ser Gln Gly Leu Arg Asp Gln Gly Asn Gln Glu 180 185 190 Gln Asp Pro Asn Ile Ser Asn Gly Glu Glu Glu Glu Glu Lys Glu Pro 195 200 205 Gly Glu Val Gly Thr His Asn Asp Asn Gln Glu Arg Lys Thr Glu Leu 210 215 220 Pro Arg Glu His Ala Asn Ser Lys Gln Glu Glu Asp Asn Thr Gln Ser 225 230 235 240 Asp Asp Ile Leu Glu Glu Ser Asp Gln Pro Thr Gln Val Ser Lys Met 245 250 255 Gln Glu Asp Glu Phe Asp Gln Gly Asn Gln Glu Gln Glu Asp Asn Ser 260 265 270 Asn Ala Glu Met Glu Glu Glu Asn Ala Ser Asn Val Asn Lys His Ile 275 280 285 Gln Glu Thr Glu Trp Gln Ser Gln Glu Gly Lys Thr Gly Leu Glu Ala 290 295 300 Ile Ser Asn His Lys Glu Thr Glu Glu Lys Thr Val Ser Glu Ala Leu 305 310 315 320 Leu Met Glu Pro Thr Asp Asp Gly Asn Thr Thr Pro Arg Asn His Gly 325 330 335 Val Asp Asp Asp Gly Asp Asp Asp Gly Asp Asp Gly Gly Thr Asp Gly 340 345 350 Pro Arg His Ser Ala Ser Asp Asp Tyr Phe Ile Pro Ser Gln Ala Phe 355 360 365 Leu Glu Ala Glu Arg Ala Gln Ser Ile Ala Tyr His Leu Lys Ile Glu 370 375 380 Glu Gln Arg Glu Lys Val His Glu Asn Glu Asn Ile Gly Thr Thr Glu 385 390 395 400 Pro Gly Glu His Gln Glu Ala Lys Lys Ala Glu Asn Ser Ser Asn Glu 405 410 415 Glu Glu Thr Ser Ser Glu Gly Asn Met Arg Val His Ala Val Asp Ser 420 425 430 Cys Met Ser Phe Gln Cys Lys Arg Gly His Ile Cys Lys Ala Asp Gln 435 440 445 Gln Gly Lys Pro His Cys Val Cys Gln Asp Pro Val Thr Cys Pro Pro 450 455 460 Thr Lys Pro Leu Asp Gln Val Cys Gly Thr Asp Asn Gln Thr Tyr Ala 465 470 475 480 Ser Ser Cys His Leu Phe Ala Thr Lys Cys Arg Leu Glu Gly Thr Lys 485 490 495 Lys Gly His Gln Leu Gln Leu Asp Tyr Phe Gly Ala Cys Lys Ser Ile 500 505 510 Pro Thr Cys Thr Asp Phe Glu Val Ile Gln Phe Pro Leu Arg Met Arg 515 520 525 Asp Trp Leu Lys Asn Ile Leu Met Gln Leu Tyr Glu Ala Asn Ser Glu 530 535 540 His Ala Gly Tyr Leu Asn Glu Lys Gln Arg Asn Lys Val Lys Lys Ile 545 550 555 560 Tyr Leu Asp Glu Lys Arg Leu Leu Ala Gly Asp His Pro Ile Asp Leu 565 570 575 Leu Leu Arg Asp Phe Lys Lys Asn Tyr His Met Tyr Val Tyr Pro Val 580 585 590 His Trp Gln Phe Ser Glu Leu Asp Gln His Pro Met Asp Arg Val Leu 595 600 605 Thr His Ser Glu Leu Ala Pro Leu Arg Ala Ser Leu Val Pro Met Glu 610 615 620 His Cys Ile Thr Arg Phe Phe Glu Glu Cys Asp Pro Asn Lys Asp Lys 625 630 635 640 His Ile Thr Leu Lys Glu Trp Gly His Cys Phe Gly Ile Lys Glu Glu 645 650 655 Asp Ile Asp Glu Asn Leu Leu Phe 660 <210> 274 <211> 111 <212> PRT <213> Homo sapiens <400> 274 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Gly Asp Tyr Tyr Cys Ile Ser Tyr Thr Ser Ser 85 90 95 Asn Pro Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 275 <211> 106 <212> PRT <213> Homo sapiens <400> 275 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Lys Pro Tyr Asp Phe Trp Thr Glu 100 105 <210> 276 <211> 272 <212> PRT <213> Homo sapiens <400> 276 Met Ser Cys His Asn Cys Ser Asp Pro Gln Val Leu Cys Ser Ser Gly 1 5 10 15 Gln Leu Phe Leu Gln Pro Leu Trp Asp His Leu Arg Ser Trp Glu Ala 20 25 30 Leu Leu Gln Ser Pro Phe Phe Pro Val Ile Phe Ser Ile Thr Thr Tyr 35 40 45 Val Gly Phe Cys Leu Pro Phe Val Val Leu Asp Ile Leu Cys Ser Trp 50 55 60 Val Pro Ala Leu Arg Arg Tyr Lys Ile His Pro Asp Phe Ser Pro Ser 65 70 75 80 Ala Gln Gln Leu Leu Pro Cys Leu Gly Gln Thr Leu Tyr Gln His Val 85 90 95 Met Phe Val Phe Pro Val Thr Leu Leu His Trp Ala Arg Ser Pro Ala 100 105 110 Leu Leu Pro His Glu Ala Pro Glu Leu Leu Leu Leu Leu His His Ile 115 120 125 Leu Phe Cys Leu Leu Leu Phe Asp Met Glu Phe Phe Val Trp His Leu 130 135 140 Leu His His Lys Val Pro Trp Leu Tyr Arg Thr Phe His Lys Val His 145 150 155 160 His Gln Asn Ser Ser Ser Phe Ala Leu Ala Thr Gln Tyr Met Ser Val 165 170 175 Trp Glu Leu Phe Ser Leu Gly Phe Phe Asp Met Met Asn Val Thr Leu 180 185 190 Leu Gly Cys His Pro Leu Thr Thr Leu Thr Phe His Val Val Asn Ile 195 200 205 Trp Leu Ser Val Glu Asp His Ser Gly Tyr Asn Phe Pro Trp Ser Thr 210 215 220 His Arg Leu Val Pro Phe Gly Trp Tyr Gly Gly Val Val His His Asp 225 230 235 240 Leu His His Ser His Phe Asn Cys Asn Phe Ala Pro Tyr Phe Thr His 245 250 255 Trp Asp Lys Ile Leu Gly Thr Leu Arg Thr Ala Ser Val Pro Ala Arg 260 265 270 <210> 277 <211> 267 <212> PRT <213> Homo sapiens <400> 277 Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 1 5 10 15 Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 20 25 30 Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 35 40 45 Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 50 55 60 Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser His Val Ile Glu 65 70 75 80 Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 85 90 95 Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 100 105 110 Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 115 120 125 Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 130 135 140 Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 145 150 155 160 Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 165 170 175 Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 180 185 190 Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 195 200 205 Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 210 215 220 Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 225 230 235 240 Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 245 250 255 Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 260 265 <210> 278 <211> 247 <212> PRT <213> Homo sapiens <400> 278 Met Leu Gln Asn Ser Ala Val Leu Leu Val Leu Val Ile Ser Ala Ser 1 5 10 15 Ala Thr His Glu Ala Glu Gln Asn Asp Ser Val Ser Pro Arg Lys Ser 20 25 30 Arg Val Ala Ala Gln Asn Ser Ala Glu Val Val Arg Cys Leu Asn Ser 35 40 45 Ala Leu Gln Val Gly Cys Gly Ala Phe Ala Cys Leu Glu Asn Ser Thr 50 55 60 Cys Asp Thr Asp Gly Met Tyr Asp Ile Cys Lys Ser Phe Leu Tyr Ser 65 70 75 80 Ala Ala Lys Phe Asp Thr Gln Gly Lys Ala Phe Val Lys Glu Ser Leu 85 90 95 Lys Cys Ile Ala Asn Gly Val Thr Ser Lys Val Phe Leu Ala Ile Arg 100 105 110 Arg Cys Ser Thr Phe Gln Arg Met Ile Ala Glu Val Gln Glu Glu Cys 115 120 125 Tyr Ser Lys Leu Asn Val Cys Ser Ile Ala Lys Arg Asn Pro Glu Ala 130 135 140 Ile Thr Glu Val Val Gln Leu Pro Asn His Phe Ser Asn Arg Tyr Tyr 145 150 155 160 Asn Arg Leu Val Arg Ser Leu Leu Glu Cys Asp Glu Asp Thr Val Ser 165 170 175 Thr Ile Arg Asp Ser Leu Met Glu Lys Ile Gly Pro Asn Met Ala Ser 180 185 190 Leu Phe His Ile Leu Gln Thr Asp His Cys Ala Gln Thr His Pro Arg 195 200 205 Ala Asp Phe Asn Arg Arg Arg Thr Asn Glu Pro Gln Lys Leu Lys Val 210 215 220 Leu Leu Arg Asn Leu Arg Gly Glu Glu Asp Ser Pro Ser His Ile Lys 225 230 235 240 Arg Thr Ser His Glu Ser Ala 245 <210> 279 <211> 317 <212> PRT <213> Homo sapiens <400> 279 Gly Thr Arg Gln Val Leu Asn Ile Asn Asp His Ala Pro Glu Phe Ser 1 5 10 15 Gln Tyr Tyr Glu Thr Tyr Val Cys Glu Asn Ala Gly Ser Gly Gln Val 20 25 30 Ile Gln Thr Ile Ser Ala Val Asp Arg Asp Glu Ser Ile Glu Glu His 35 40 45 His Phe Tyr Phe Asn Leu Ser Val Glu Asp Thr Asn Asn Ser Ser Phe 50 55 60 Thr Ile Ile Asp Asn Gln Asp Asn Thr Ala Val Ile Leu Thr Asn Arg 65 70 75 80 Thr Gly Phe Asn Leu Gln Glu Glu Pro Val Phe Tyr Ile Ser Ile Leu 85 90 95 Ile Ala Asp Asn Gly Ile Pro Ser Leu Thr Ser Thr Asn Thr Leu Thr 100 105 110 Ile His Val Cys Asp Cys Gly Asp Ser Gly Ser Thr Gln Thr Cys Gln 115 120 125 Tyr Gln Glu Leu Val Leu Ser Met Gly Phe Lys Thr Glu Val Ile Ile 130 135 140 Ala Ile Leu Ile Cys Ile Met Ile Ile Phe Gly Phe Ile Phe Leu Thr 145 150 155 160 Leu Gly Leu Lys Gln Arg Arg Lys Gln Ile Leu Phe Pro Glu Lys Ser 165 170 175 Glu Asp Phe Arg Glu Asn Ile Phe Gln Tyr Asp Asp Glu Gly Gly Gly 180 185 190 Glu Glu Asp Thr Glu Ala Phe Asp Ile Ala Glu Leu Arg Ser Ser Thr 195 200 205 Ile Met Arg Glu Arg Lys Thr Arg Lys Thr Thr Ser Ala Glu Ile Arg 210 215 220 Ser Leu Tyr Arg Gln Ser Leu Gln Val Gly Pro Asp Ser Ala Ile Phe 225 230 235 240 Arg Lys Phe Ile Leu Glu Lys Leu Glu Glu Ala Asn Thr Asp Pro Cys 245 250 255 Ala Pro Pro Phe Asp Ser Leu Gln Thr Tyr Ala Phe Glu Gly Thr Gly 260 265 270 Ser Leu Ala Gly Ser Leu Ser Ser Leu Glu Ser Ala Val Ser Asp Gln 275 280 285 Asp Glu Ser Tyr Asp Tyr Leu Asn Glu Leu Gly Pro Arg Phe Lys Arg 290 295 300 Leu Ala Cys Met Phe Gly Ser Ala Val Gln Ser Asn Asn 305 310 315 <210> 280 <211> 1158 <212> PRT <213> Homo sapiens <400> 280 Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu 1 5 10 15 Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp 20 25 30 Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu 35 40 45 Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro 50 55 60 Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly 65 70 75 80 Thr Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys 85 90 95 Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 100 105 110 Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr 115 120 125 Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu 130 135 140 Glu Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 145 150 155 160 Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser 165 170 175 Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 180 185 190 Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn 195 200 205 Pro Gly Glu Glu Thr His Val Glu Ala Gln Glu His Gln Pro Glu Pro 210 215 220 Glu Glu Glu Thr Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu 225 230 235 240 Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 245 250 255 Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 260 265 270 Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu 275 280 285 Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp 290 295 300 Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro 305 310 315 320 Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys 325 330 335 Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu 340 345 350 Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg 355 360 365 Lys Gly Glu Glu Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Lys 370 375 380 Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 385 390 395 400 Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 405 410 415 Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 420 425 430 Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 435 440 445 Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 450 455 460 Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 465 470 475 480 Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr 485 490 495 Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro 500 505 510 Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn 515 520 525 Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro 530 535 540 Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp Asp Leu 545 550 555 560 Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 565 570 575 Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys 580 585 590 Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 595 600 605 Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala Gly Ile 610 615 620 His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln 625 630 635 640 Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu 645 650 655 Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly 660 665 670 Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu 675 680 685 Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp 690 695 700 Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr 705 710 715 720 Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro 725 730 735 Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp Met Glu 740 745 750 Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu 755 760 765 Val Ser Tyr Pro Tyr Asp Met Ala Arg Thr Pro Thr Gln Glu Gln Leu 770 775 780 Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val 785 790 795 800 Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp Leu Ala 805 810 815 Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr Arg Gly 820 825 830 Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val Asn Gly 835 840 845 Ala Lys Trp Asn Pro Arg Thr Gly Thr Ile Asn Asp Phe Ser Tyr Leu 850 855 860 His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe 865 870 875 880 Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala 885 890 895 Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val 900 905 910 Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser Val Ser 915 920 925 Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr Trp Arg 930 935 940 Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu Gly Tyr 945 950 955 960 Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly Ala Thr 965 970 975 Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu 980 985 990 Ile Met Ala Met Asn Gly Asn Arg Pro Ile Pro His Ile Asp Pro Ser 995 1000 1005 Arg Pro Met Thr Pro Gln Gln Arg Arg Leu Gln Gln Arg Arg Leu Gln 1010 1015 1020 His Arg Leu Arg Leu Arg Ala Gln Met Arg Leu Arg Arg Leu Asn Ala 1025 1030 1035 1040 Thr Thr Thr Leu Gly Pro His Thr Val Pro Pro Thr Leu Pro Pro Ala 1045 1050 1055 Pro Ala Thr Thr Leu Ser Thr Thr Ile Glu Pro Trp Gly Leu Ile Pro 1060 1065 1070 Pro Thr Thr Ala Gly Trp Glu Glu Ser Glu Thr Glu Thr Tyr Thr Glu 1075 1080 1085 Val Val Thr Glu Phe Gly Thr Glu Val Glu Pro Glu Phe Gly Thr Lys 1090 1095 1100 Val Glu Pro Glu Phe Glu Thr Gln Leu Glu Pro Glu Phe Glu Thr Gln 1105 1110 1115 1120 Leu Glu Pro Glu Phe Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu 1125 1130 1135 Ile Ala Thr Gly Gln Ala Phe Pro Phe Thr Thr Val Glu Thr Tyr Thr 1140 1145 1150 Val Asn Phe Gly Asp Phe 1155 <210> 281 <211> 296 <212> PRT <213> Homo sapiens <400> 281 Met Thr Leu Asn Asn Val Thr Met Arg Gln Gly Thr Val Gly Met Gln 1 5 10 15 Pro Gln Gln Gln Arg Trp Ser Ile Pro Ala Asp Gly Arg His Leu Met 20 25 30 Val Gln Lys Glu Pro His Gln Tyr Ser His Arg Asn Arg His Ser Ala 35 40 45 Thr Pro Glu Asp His Cys Arg Arg Ser Trp Ser Ser Asp Ser Thr Asp 50 55 60 Ser Val Ile Ser Ser Glu Ser Gly Asn Thr Tyr Tyr Arg Val Val Leu 65 70 75 80 Ile Gly Glu Gln Gly Val Gly Lys Ser Thr Leu Ala Asn Ile Phe Ala 85 90 95 Gly Val His Asp Ser Met Asp Ser Asp Cys Glu Val Leu Gly Glu Asp 100 105 110 Thr Tyr Glu Arg Thr Leu Met Val Asp Gly Glu Ser Ala Thr Ile Ile 115 120 125 Leu Leu Asp Met Trp Glu Asn Lys Gly Glu Asn Glu Trp Leu His Asp 130 135 140 His Cys Met Gln Val Gly Asp Ala Tyr Leu Ile Val Tyr Ser Ile Thr 145 150 155 160 Asp Arg Ala Ser Phe Glu Lys Ala Ser Glu Leu Arg Ile Gln Leu Arg 165 170 175 Arg Ala Arg Gln Thr Glu Asp Ile Pro Ile Ile Leu Val Gly Asn Lys 180 185 190 Ser Asp Leu Val Arg Cys Arg Glu Val Ser Val Ser Glu Gly Arg Ala 195 200 205 Cys Ala Val Val Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Val 210 215 220 Gln His Asn Val Lys Glu Leu Phe Glu Gly Ile Val Arg Gln Val Arg 225 230 235 240 Leu Arg Arg Asp Ser Lys Glu Lys Asn Glu Arg Arg Leu Ala Tyr Gln 245 250 255 Lys Arg Lys Glu Ser Met Pro Arg Lys Ala Arg Arg Phe Trp Gly Lys 260 265 270 Ile Val Ala Lys Asn Asn Lys Asn Met Ala Phe Lys Leu Lys Ser Lys 275 280 285 Ser Cys His Asp Leu Ser Val Leu 290 295 <210> 282 <211> 338 <212> PRT <213> Homo sapiens <400> 282 Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 1 5 10 15 Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 20 25 30 Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 35 40 45 Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 50 55 60 Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 65 70 75 80 Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 85 90 95 Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 100 105 110 Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 115 120 125 Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 130 135 140 Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 145 150 155 160 Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 165 170 175 Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 180 185 190 Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 195 200 205 Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 210 215 220 Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 225 230 235 240 Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 245 250 255 Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 260 265 270 Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 275 280 285 Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 290 295 300 Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 305 310 315 320 Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 325 330 335 Leu Asn <210> 283 <211> 377 <212> PRT <213> Homo sapiens <400> 283 Met Lys Phe Pro Gly Pro Leu Glu Asn Gln Arg Leu Ser Phe Leu Leu 1 5 10 15 Glu Lys Ala Ile Thr Arg Glu Ala Gln Met Trp Lys Val Asn Val Arg 20 25 30 Lys Met Pro Ser Asn Gln Asn Val Ser Pro Ser Gln Arg Asp Glu Val 35 40 45 Ile Gln Trp Leu Ala Lys Leu Lys Tyr Gln Phe Asn Leu Tyr Pro Glu 50 55 60 Thr Phe Ala Leu Ala Ser Ser Leu Leu Asp Arg Phe Leu Ala Thr Val 65 70 75 80 Lys Ala His Pro Lys Tyr Leu Ser Cys Ile Ala Ile Ser Cys Phe Phe 85 90 95 Leu Ala Ala Lys Thr Val Glu Glu Asp Glu Arg Ile Pro Val Leu Lys 100 105 110 Val Leu Ala Arg Asp Ser Phe Cys Gly Cys Ser Ser Ser Glu Ile Leu 115 120 125 Arg Met Glu Arg Ile Ile Leu Asp Lys Leu Asn Trp Asp Leu His Thr 130 135 140 Ala Thr Pro Leu Asp Phe Leu His Ile Phe His Ala Ile Ala Val Ser 145 150 155 160 Thr Arg Pro Gln Leu Leu Phe Ser Leu Pro Lys Leu Ser Pro Ser Gln 165 170 175 His Leu Ala Val Leu Thr Lys Gln Leu Leu His Cys Met Ala Cys Asn 180 185 190 Gln Leu Leu Gln Phe Arg Gly Ser Met Leu Ala Leu Ala Met Val Ser 195 200 205 Leu Glu Met Glu Lys Leu Ile Pro Asp Trp Leu Ser Leu Thr Ile Glu 210 215 220 Leu Leu Gln Lys Ala Gln Met Asp Ser Ser Gln Leu Ile His Cys Arg 225 230 235 240 Glu Leu Val Ala His His Leu Ser Thr Leu Gln Ser Ser Leu Pro Leu 245 250 255 Asn Ser Val Tyr Val Tyr Arg Pro Leu Lys His Thr Leu Val Thr Cys 260 265 270 Asp Lys Gly Val Phe Arg Leu His Pro Ser Ser Val Pro Gly Pro Asp 275 280 285 Phe Ser Lys Asp Asn Ser Lys Pro Glu Val Pro Val Arg Gly Thr Ala 290 295 300 Ala Phe Tyr His His Leu Pro Ala Ala Ser Gly Cys Lys Gln Thr Ser 305 310 315 320 Thr Lys Arg Lys Val Glu Glu Met Glu Val Asp Asp Phe Tyr Asp Gly 325 330 335 Ile Lys Arg Leu Tyr Asn Glu Asp Asn Val Ser Glu Asn Val Gly Ser 340 345 350 Val Cys Gly Thr Asp Leu Ser Arg Gln Glu Gly His Ala Ser Pro Cys 355 360 365 Pro Pro Leu Gln Pro Val Ser Val Met 370 375 <210> 284 <211> 572 <212> PRT <213> Homo sapiens <400> 284 Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 1 5 10 15 Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 20 25 30 Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 35 40 45 Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 50 55 60 Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 65 70 75 80 Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 85 90 95 Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 100 105 110 Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 115 120 125 Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp 130 135 140 His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 145 150 155 160 Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 165 170 175 Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 180 185 190 Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu 195 200 205 Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 210 215 220 Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile 225 230 235 240 Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met 245 250 255 Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 260 265 270 Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 275 280 285 His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 290 295 300 Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 305 310 315 320 Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 325 330 335 Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 340 345 350 Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 355 360 365 Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 370 375 380 Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 385 390 395 400 Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 405 410 415 Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn 420 425 430 Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 435 440 445 Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 450 455 460 Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 465 470 475 480 Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 485 490 495 Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 500 505 510 Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 515 520 525 Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 530 535 540 Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 545 550 555 560 Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 565 570 <210> 285 <211> 352 <212> PRT <213> Homo sapiens <400> 285 Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 1 5 10 15 Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 20 25 30 Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 35 40 45 Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 50 55 60 Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 65 70 75 80 Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 85 90 95 Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 100 105 110 His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 115 120 125 Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 130 135 140 Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 145 150 155 160 Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 165 170 175 Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 180 185 190 Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 195 200 205 Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 210 215 220 Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 225 230 235 240 Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 245 250 255 Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 260 265 270 Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 275 280 285 Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 290 295 300 Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 305 310 315 320 Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 325 330 335 His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 340 345 350 <210> 286 <211> 2490 <212> PRT <213> Homo sapiens <400> 286 Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu 1 5 10 15 Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu 20 25 30 Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly 35 40 45 Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val 50 55 60 Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr 65 70 75 80 Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val 85 90 95 Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala 100 105 110 Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu 115 120 125 Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val 130 135 140 Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser 145 150 155 160 Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val 165 170 175 Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln 180 185 190 Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly 195 200 205 Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys 210 215 220 Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser 225 230 235 240 Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys 245 250 255 Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe 260 265 270 Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro 275 280 285 Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp 290 295 300 Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr 305 310 315 320 Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr 325 330 335 Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp 340 345 350 Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu 355 360 365 Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg 370 375 380 Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro 385 390 395 400 Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser 405 410 415 Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg 420 425 430 Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly 435 440 445 Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln 450 455 460 Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu 465 470 475 480 Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu 485 490 495 Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser 500 505 510 Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr 515 520 525 Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val 530 535 540 Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile 545 550 555 560 Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile 565 570 575 Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr 580 585 590 Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val 595 600 605 Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe 610 615 620 Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp 625 630 635 640 Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu 645 650 655 Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His 660 665 670 Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu 675 680 685 Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser 690 695 700 Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly 705 710 715 720 Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu 725 730 735 Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn 740 745 750 Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys 755 760 765 Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His 770 775 780 Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys 785 790 795 800 Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu 805 810 815 Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys 820 825 830 Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr 835 840 845 Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln 850 855 860 His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala 865 870 875 880 Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu 885 890 895 Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu 900 905 910 Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln 915 920 925 Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln 930 935 940 Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu 945 950 955 960 Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala 965 970 975 Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro 980 985 990 Pro Gln Thr Val Ala Glu Leu Val Gly Lys Pro Ser His Gln Met Ser 995 1000 1005 Arg Ser Asp Ala Glu Ser Leu Ala Gly Val Thr Lys Leu Asn Asn Ser 1010 1015 1020 Lys Ser Val Ala Ser Leu Asn Arg Ser Pro Glu Arg Arg Lys His Glu 1025 1030 1035 1040 Ser Asp Ser Ser Ser Ile Glu Asp Pro Gly Gln Ala Tyr Val Leu Gly 1045 1050 1055 Met Thr Met His Ser Ser Gly Asn Ser Ser Ser Gln Val Pro Leu Lys 1060 1065 1070 Glu Asn Asp Val Leu His Lys Arg Trp Ser Ile Val Ser Ser Pro Glu 1075 1080 1085 Arg Glu Ile Thr Leu Val Asn Leu Lys Lys Asp Ala Lys Tyr Gly Leu 1090 1095 1100 Gly Phe Gln Ile Ile Gly Gly Glu Lys Met Gly Arg Leu Asp Leu Gly 1105 1110 1115 1120 Ile Phe Ile Ser Ser Val Ala Pro Gly Gly Pro Ala Asp Leu Asp Gly 1125 1130 1135 Cys Leu Lys Pro Gly Asp Arg Leu Ile Ser Val Asn Ser Val Ser Leu 1140 1145 1150 Glu Gly Val Ser His His Ala Ala Ile Glu Ile Leu Gln Asn Ala Pro 1155 1160 1165 Glu Asp Val Thr Leu Val Ile Ser Gln Pro Lys Glu Lys Ile Ser Lys 1170 1175 1180 Val Pro Ser Thr Pro Val His Leu Thr Asn Glu Met Lys Asn Tyr Met 1185 1190 1195 1200 Lys Lys Ser Ser Tyr Met Gln Asp Ser Ala Ile Asp Ser Ser Ser Lys 1205 1210 1215 Asp His His Trp Ser Arg Gly Thr Leu Arg His Ile Ser Glu Asn Ser 1220 1225 1230 Phe Gly Pro Ser Gly Gly Leu Arg Glu Gly Ser Leu Ser Ser Gln Asp 1235 1240 1245 Ser Arg Thr Glu Ser Ala Ser Leu Ser Gln Ser Gln Val Asn Gly Phe 1250 1255 1260 Phe Ala Ser His Leu Gly Asp Gln Thr Trp Gln Glu Ser Gln His Gly 1265 1270 1275 1280 Ser Pro Ser Pro Ser Val Ile Ser Lys Ala Thr Glu Lys Glu Thr Phe 1285 1290 1295 Thr Asp Ser Asn Gln Ser Lys Thr Lys Lys Pro Gly Ile Ser Asp Val 1300 1305 1310 Thr Asp Tyr Ser Asp Arg Gly Asp Ser Asp Met Asp Glu Ala Thr Tyr 1315 1320 1325 Ser Ser Ser Gln Asp His Gln Thr Pro Lys Gln Glu Ser Ser Ser Ser 1330 1335 1340 Val Asn Thr Ser Asn Lys Met Asn Phe Lys Thr Phe Ser Ser Ser Pro 1345 1350 1355 1360 Pro Lys Pro Gly Asp Ile Phe Glu Val Glu Leu Ala Lys Asn Asp Asn 1365 1370 1375 Ser Leu Gly Ile Ser Val Thr Val Leu Phe Asp Lys Gly Gly Val Asn 1380 1385 1390 Thr Ser Val Arg His Gly Gly Ile Tyr Val Lys Ala Val Ile Pro Gln 1395 1400 1405 Gly Ala Ala Glu Ser Asp Gly Arg Ile His Lys Gly Asp Arg Val Leu 1410 1415 1420 Ala Val Asn Gly Val Ser Leu Glu Gly Ala Thr His Lys Gln Ala Val 1425 1430 1435 1440 Glu Thr Leu Arg Asn Thr Gly Gln Val Val His Leu Leu Leu Glu Lys 1445 1450 1455 Gly Gln Ser Pro Thr Ser Lys Glu His Val Pro Val Thr Pro Gln Cys 1460 1465 1470 Thr Leu Ser Asp Gln Asn Ala Gln Gly Gln Gly Pro Glu Lys Val Lys 1475 1480 1485 Lys Thr Thr Gln Val Lys Asp Tyr Ser Phe Val Thr Glu Glu Asn Thr 1490 1495 1500 Phe Glu Val Lys Leu Phe Lys Asn Ser Ser Gly Leu Gly Phe Ser Phe 1505 1510 1515 1520 Ser Arg Glu Asp Asn Leu Ile Pro Glu Gln Ile Asn Ala Ser Ile Val 1525 1530 1535 Arg Val Lys Lys Leu Phe Pro Gly Gln Pro Ala Ala Glu Ser Gly Lys 1540 1545 1550 Ile Asp Val Gly Asp Val Ile Leu Lys Val Asn Gly Ala Ser Leu Lys 1555 1560 1565 Gly Leu Ser Gln Gln Glu Val Ile Ser Ala Leu Arg Gly Thr Ala Pro 1570 1575 1580 Glu Val Phe Leu Leu Leu Cys Arg Pro Pro Pro Gly Val Leu Pro Glu 1585 1590 1595 1600 Ile Asp Thr Ala Leu Leu Thr Pro Leu Gln Ser Pro Ala Gln Val Leu 1605 1610 1615 Pro Asn Ser Ser Lys Asp Ser Ser Gln Pro Ser Cys Val Glu Gln Ser 1620 1625 1630 Thr Ser Ser Asp Glu Asn Glu Met Ser Asp Lys Ser Lys Lys Gln Cys 1635 1640 1645 Lys Ser Pro Ser Arg Arg Asp Ser Tyr Ser Asp Ser Ser Gly Ser Gly 1650 1655 1660 Glu Asp Asp Leu Val Thr Ala Pro Ala Asn Ile Ser Asn Ser Thr Trp 1665 1670 1675 1680 Ser Ser Ala Leu His Gln Thr Leu Ser Asn Met Val Ser Gln Ala Gln 1685 1690 1695 Ser His His Glu Ala Pro Lys Ser Gln Glu Asp Thr Ile Cys Thr Met 1700 1705 1710 Phe Tyr Tyr Pro Gln Lys Ile Pro Asn Lys Pro Glu Phe Glu Asp Ser 1715 1720 1725 Asn Pro Ser Pro Leu Pro Pro Asp Met Ala Pro Gly Gln Ser Tyr Gln 1730 1735 1740 Pro Gln Ser Glu Ser Ala Ser Ser Ser Ser Met Asp Lys Tyr His Ile 1745 1750 1755 1760 His His Ile Ser Glu Pro Thr Arg Gln Glu Asn Trp Thr Pro Leu Lys 1765 1770 1775 Asn Asp Leu Glu Asn His Leu Glu Asp Phe Glu Leu Glu Val Glu Leu 1780 1785 1790 Leu Ile Thr Leu Ile Lys Ser Glu Lys Gly Ser Leu Gly Phe Thr Val 1795 1800 1805 Thr Lys Gly Asn Gln Arg Ile Gly Cys Tyr Val His Asp Val Ile Gln 1810 1815 1820 Asp Pro Ala Lys Ser Asp Gly Arg Leu Lys Pro Gly Asp Arg Leu Ile 1825 1830 1835 1840 Lys Val Asn Asp Thr Asp Val Thr Asn Met Thr His Thr Asp Ala Val 1845 1850 1855 Asn Leu Leu Arg Ala Ala Ser Lys Thr Val Arg Leu Val Ile Gly Arg 1860 1865 1870 Val Leu Glu Leu Pro Arg Ile Pro Met Leu Pro His Leu Leu Pro Asp 1875 1880 1885 Ile Thr Leu Thr Cys Asn Lys Glu Glu Leu Gly Phe Ser Leu Cys Gly 1890 1895 1900 Gly His Asp Ser Leu Tyr Gln Val Val Tyr Ile Ser Asp Ile Asn Pro 1905 1910 1915 1920 Arg Ser Val Ala Ala Ile Glu Gly Asn Leu Gln Leu Leu Asp Val Ile 1925 1930 1935 His Tyr Val Asn Gly Val Ser Thr Gln Gly Met Thr Leu Glu Glu Val 1940 1945 1950 Asn Arg Ala Leu Asp Met Ser Leu Pro Ser Leu Val Leu Lys Ala Thr 1955 1960 1965 Arg Asn Asp Leu Pro Val Val Pro Ser Ser Lys Arg Ser Ala Val Ser 1970 1975 1980 Ala Pro Lys Ser Thr Lys Gly Asn Gly Ser Tyr Ser Val Gly Ser Cys 1985 1990 1995 2000 Ser Gln Pro Ala Leu Thr Pro Asn Asp Ser Phe Ser Thr Val Ala Gly 2005 2010 2015 Glu Glu Ile Asn Glu Ile Ser Tyr Pro Lys Gly Lys Cys Ser Thr Tyr 2020 2025 2030 Gln Ile Lys Gly Ser Pro Asn Leu Thr Leu Pro Lys Glu Ser Tyr Ile 2035 2040 2045 Gln Glu Asp Asp Ile Tyr Asp Asp Ser Gln Glu Ala Glu Val Ile Gln 2050 2055 2060 Ser Leu Leu Asp Val Val Asp Glu Glu Ala Gln Asn Leu Leu Asn Glu 2065 2070 2075 2080 Asn Asn Ala Ala Gly Tyr Ser Cys Gly Pro Gly Thr Leu Lys Met Asn 2085 2090 2095 Gly Lys Leu Ser Glu Glu Arg Thr Glu Asp Thr Asp Cys Asp Gly Ser 2100 2105 2110 Pro Leu Pro Glu Tyr Phe Thr Glu Ala Thr Lys Met Asn Gly Cys Glu 2115 2120 2125 Glu Tyr Cys Glu Glu Lys Val Lys Ser Glu Ser Leu Ile Gln Lys Pro 2130 2135 2140 Gln Glu Lys Lys Thr Asp Asp Asp Glu Ile Thr Trp Gly Asn Asp Glu 2145 2150 2155 2160 Leu Pro Ile Glu Arg Thr Asn His Glu Asp Ser Asp Lys Asp His Ser 2165 2170 2175 Phe Leu Thr Asn Asp Glu Leu Ala Val Leu Pro Val Val Lys Val Leu 2180 2185 2190 Pro Ser Gly Lys Tyr Thr Gly Ala Asn Leu Lys Ser Val Ile Arg Val 2195 2200 2205 Leu Arg Gly Leu Leu Asp Gln Gly Ile Pro Ser Lys Glu Leu Glu Asn 2210 2215 2220 Leu Gln Glu Leu Lys Pro Leu Asp Gln Cys Leu Ile Gly Gln Thr Lys 2225 2230 2235 2240 Glu Asn Arg Arg Lys Asn Arg Tyr Lys Asn Ile Leu Pro Tyr Asp Ala 2245 2250 2255 Thr Arg Val Pro Leu Gly Asp Glu Gly Gly Tyr Ile Asn Ala Ser Phe 2260 2265 2270 Ile Lys Ile Pro Val Gly Lys Glu Glu Phe Val Tyr Ile Ala Cys Gln 2275 2280 2285 Gly Pro Leu Pro Thr Thr Val Gly Asp Phe Trp Gln Met Ile Trp Glu 2290 2295 2300 Gln Lys Ser Thr Val Ile Ala Met Met Thr Gln Glu Val Glu Gly Glu 2305 2310 2315 2320 Lys Ile Lys Cys Gln Arg Tyr Trp Pro Asn Ile Leu Gly Lys Thr Thr 2325 2330 2335 Met Val Ser Asn Arg Leu Arg Leu Ala Leu Val Arg Met Gln Gln Leu 2340 2345 2350 Lys Gly Phe Val Val Arg Ala Met Thr Leu Glu Asp Ile Gln Thr Arg 2355 2360 2365 Glu Val Arg His Ile Ser His Leu Asn Phe Thr Ala Trp Pro Asp His 2370 2375 2380 Asp Thr Pro Ser Gln Pro Asp Asp Leu Leu Thr Phe Ile Ser Tyr Met 2385 2390 2395 2400 Arg His Ile His Arg Ser Gly Pro Ile Ile Thr His Cys Ser Ala Gly 2405 2410 2415 Ile Gly Arg Ser Gly Thr Leu Ile Cys Ile Asp Val Val Leu Gly Leu 2420 2425 2430 Ile Ser Gln Asp Leu Asp Phe Asp Ile Ser Asp Leu Val Arg Cys Met 2435 2440 2445 Arg Leu Gln Arg His Gly Met Val Gln Thr Glu Asp Gln Tyr Ile Phe 2450 2455 2460 Cys Tyr Gln Val Ile Leu Tyr Val Leu Thr Arg Leu Gln Ala Glu Glu 2465 2470 2475 2480 Glu Gln Lys Gln Gln Pro Gln Leu Leu Lys 2485 2490 <210> 287 <211> 201 <212> PRT <213> Homo sapiens <400> 287 Met Asp Leu Ser Leu Leu Trp Val Leu Met Pro Leu Val Thr Met Ala 1 5 10 15 Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 20 25 30 Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 35 40 45 Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 50 55 60 Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 65 70 75 80 Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 85 90 95 Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 100 105 110 Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 115 120 125 Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 130 135 140 Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 145 150 155 160 Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 165 170 175 Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 180 185 190 Glu Tyr Asp Cys Glu Phe Ala Asn Val 195 200 <210> 288 <211> 1089 <212> PRT <213> Homo sapiens <400> 288 Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 1 5 10 15 Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 20 25 30 Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 35 40 45 Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 50 55 60 Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 65 70 75 80 Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 85 90 95 Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 100 105 110 Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 115 120 125 Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 130 135 140 Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 145 150 155 160 Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 165 170 175 Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 180 185 190 Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 195 200 205 Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 210 215 220 Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 225 230 235 240 Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 245 250 255 Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 260 265 270 Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 275 280 285 Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 290 295 300 Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 305 310 315 320 Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 325 330 335 Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 340 345 350 Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 355 360 365 Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 370 375 380 Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 385 390 395 400 Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 405 410 415 Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 420 425 430 Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 435 440 445 Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 450 455 460 Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 465 470 475 480 Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 485 490 495 Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 500 505 510 Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 515 520 525 Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 530 535 540 Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 545 550 555 560 Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 565 570 575 Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 580 585 590 Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 595 600 605 Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 610 615 620 Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 625 630 635 640 Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 645 650 655 Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 660 665 670 Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 675 680 685 Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 690 695 700 Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 705 710 715 720 Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 725 730 735 Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 740 745 750 Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 755 760 765 Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 770 775 780 Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 785 790 795 800 Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 805 810 815 Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 820 825 830 Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 835 840 845 Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 850 855 860 Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 865 870 875 880 Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 885 890 895 Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 900 905 910 Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 915 920 925 Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 930 935 940 His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 945 950 955 960 Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 965 970 975 Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 980 985 990 Tyr Lys Asn Glu Glu Asp Lys Leu Lys Asp Trp Glu Gly Gly Leu Asp 995 1000 1005 Glu Gln Arg Leu Ser Ala Asp Ser Gly Tyr Ile Ile Pro Leu Pro Asp 1010 1015 1020 Ile Asp Pro Val Pro Glu Glu Glu Asp Leu Gly Lys Arg Asn Arg His 1025 1030 1035 1040 Ser Ser Gln Thr Ser Glu Glu Ser Ala Ile Glu Thr Gly Ser Ser Ser 1045 1050 1055 Ser Thr Phe Ile Lys Arg Glu Asp Glu Thr Ile Glu Asp Ile Asp Met 1060 1065 1070 Met Asp Asp Ile Gly Ile Asp Ser Ser Asp Leu Val Glu Asp Ser Phe 1075 1080 1085 Leu <210> 289 <211> 865 <212> PRT <213> Homo sapiens <400> 289 Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 1 5 10 15 Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 20 25 30 Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 35 40 45 Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 50 55 60 Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 65 70 75 80 Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 85 90 95 Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 100 105 110 Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 115 120 125 Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 130 135 140 Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 145 150 155 160 Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 165 170 175 Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 180 185 190 Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 195 200 205 Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 210 215 220 Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 225 230 235 240 Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 245 250 255 Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 260 265 270 Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 275 280 285 Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 290 295 300 Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 305 310 315 320 Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 325 330 335 Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 340 345 350 Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 355 360 365 Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 370 375 380 Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 385 390 395 400 Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 405 410 415 Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 420 425 430 Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 435 440 445 Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 450 455 460 Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 465 470 475 480 Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 485 490 495 Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 500 505 510 Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 515 520 525 Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 530 535 540 Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 545 550 555 560 Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 565 570 575 Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 580 585 590 Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 595 600 605 Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 610 615 620 Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 625 630 635 640 Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 645 650 655 Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 660 665 670 Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 675 680 685 Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 690 695 700 Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 705 710 715 720 Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 725 730 735 Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 740 745 750 Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 755 760 765 Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 770 775 780 Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 785 790 795 800 Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 805 810 815 Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 820 825 830 Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 835 840 845 Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 850 855 860 His 865 <210> 290 <211> 254 <212> PRT <213> Homo sapiens <400> 290 Met Pro Ala Lys Thr Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 1 5 10 15 Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 20 25 30 Pro Pro Leu Gly Asp Phe Arg His Thr Ile His Ile Gly Lys Glu Gly 35 40 45 Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 50 55 60 Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 65 70 75 80 His Asn Glu Phe Phe Arg Ala Asn Ser Thr Ser Asp Ser Val Phe Thr 85 90 95 Glu Thr Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Thr Ile 100 105 110 Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Thr Phe 115 120 125 Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 130 135 140 Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 145 150 155 160 Glu Asn Gly Thr Val His Gln Gly Asp Thr Ser Trp Gly Ser Ser Gly 165 170 175 Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 180 185 190 Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 195 200 205 Thr Pro Cys Glu Leu Ile Lys Gly Lys Thr Lys Ser Glu Glu Ser Leu 210 215 220 Ser Asp Leu Thr Gly Ser Leu Leu Phe Leu Gln Leu Asp Leu Gly Pro 225 230 235 240 Ser Leu Leu Asp Glu Val Leu Asn Val Met Asp Lys Asn Lys 245 250 <210> 291 <211> 1170 <212> PRT <213> Homo sapiens <400> 291 Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 1 5 10 15 Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 20 25 30 Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 35 40 45 Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 50 55 60 Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 65 70 75 80 Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 85 90 95 Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 100 105 110 Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 115 120 125 Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 130 135 140 Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 145 150 155 160 Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 165 170 175 Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 180 185 190 Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 195 200 205 Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 210 215 220 Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 225 230 235 240 Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 245 250 255 Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 260 265 270 Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 275 280 285 Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 290 295 300 Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 305 310 315 320 Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 325 330 335 Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 340 345 350 Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 355 360 365 Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 370 375 380 Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 385 390 395 400 Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 405 410 415 Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 420 425 430 Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 435 440 445 Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 450 455 460 Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 465 470 475 480 Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 485 490 495 Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 500 505 510 Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Ala Pro Gln Phe Gly Gly 515 520 525 Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 530 535 540 Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 545 550 555 560 Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 565 570 575 Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 580 585 590 Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 595 600 605 Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 610 615 620 Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 625 630 635 640 Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 645 650 655 Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 660 665 670 Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 675 680 685 Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 690 695 700 Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 705 710 715 720 Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 725 730 735 Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 740 745 750 Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 755 760 765 Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 770 775 780 Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 785 790 795 800 Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 805 810 815 Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 820 825 830 Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 835 840 845 Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 850 855 860 Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 865 870 875 880 Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 885 890 895 Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 900 905 910 Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 915 920 925 Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 930 935 940 Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 945 950 955 960 Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 965 970 975 Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 980 985 990 Asp Pro Gly Leu Ala Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe 995 1000 1005 Ser Gly Thr Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly 1010 1015 1020 Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp 1025 1030 1035 1040 Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln 1045 1050 1055 Gly Tyr Ser Gly Leu Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro 1060 1065 1070 Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly 1075 1080 1085 Gln Val Arg Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp 1090 1095 1100 Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe 1105 1110 1115 1120 Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile Met Ala Asp Ser Gly 1125 1130 1135 Pro Ile Tyr Asp Lys Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val 1140 1145 1150 Phe Ser Gln Glu Met Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg 1155 1160 1165 Asp Pro 1170 <210> 292 <211> 139 <212> PRT <213> Homo sapiens <400> 292 Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Ser Gly Ala Thr Cys Asp 1 5 10 15 Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 20 25 30 Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Gly Asn Tyr Leu 35 40 45 Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr 50 55 60 Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Arg 65 70 75 80 Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 85 90 95 Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asn Leu Pro Phe Thr 100 105 110 Phe Gly Pro Gly Thr Lys Val His Ile Lys Arg Thr Val Ala Ala Pro 115 120 125 Ser Val Phe Ile Phe Arg His Leu Met Ser Ser 130 135 <210> 293 <211> 367 <212> PRT <213> Homo sapiens <400> 293 Met Val Met Glu Val Gly Thr Leu Asp Ala Gly Gly Leu Arg Ala Leu 1 5 10 15 Leu Gly Glu Arg Ala Ala Gln Cys Leu Leu Leu Asp Cys Arg Ser Phe 20 25 30 Phe Ala Phe Asn Ala Gly His Ile Ala Gly Ser Val Asn Val Arg Phe 35 40 45 Ser Thr Ile Val Arg Arg Arg Ala Lys Gly Ala Met Gly Leu Glu His 50 55 60 Ile Val Pro Asn Ala Glu Leu Arg Gly Arg Leu Leu Ala Gly Ala Tyr 65 70 75 80 His Ala Val Val Leu Leu Asp Glu Arg Ser Ala Ala Leu Asp Gly Ala 85 90 95 Lys Arg Asp Gly Thr Leu Ala Leu Ala Ala Gly Ala Leu Cys Arg Glu 100 105 110 Ala Arg Ala Ala Gln Val Phe Phe Leu Lys Gly Gly Tyr Glu Ala Phe 115 120 125 Ser Ala Ser Cys Pro Glu Leu Cys Ser Lys Gln Ser Thr Pro Met Gly 130 135 140 Leu Ser Leu Pro Leu Ser Thr Ser Val Pro Asp Ser Ala Glu Ser Gly 145 150 155 160 Cys Ser Ser Cys Ser Thr Pro Leu Tyr Asp Gln Gly Gly Pro Val Glu 165 170 175 Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr His Ala Ser Arg Lys 180 185 190 Asp Met Leu Asp Ala Leu Gly Ile Thr Ala Leu Ile Asn Val Ser Ala 195 200 205 Asn Cys Pro Asn His Phe Glu Gly His Tyr Gln Tyr Lys Ser Ile Pro 210 215 220 Val Glu Asp Asn His Lys Ala Asp Ile Ser Ser Trp Phe Asn Glu Ala 225 230 235 240 Ile Asp Phe Ile Asp Ser Ile Lys Asn Ala Gly Gly Arg Val Phe Val 245 250 255 His Cys Gln Ala Gly Ile Ser Arg Ser Ala Thr Ile Cys Leu Ala Tyr 260 265 270 Leu Met Arg Thr Asn Arg Val Lys Leu Asp Glu Ala Phe Glu Phe Val 275 280 285 Lys Gln Arg Arg Ser Ile Ile Ser Pro Asn Phe Ser Phe Met Gly Gln 290 295 300 Leu Leu Gln Phe Glu Ser Gln Val Leu Ala Pro His Cys Ser Ala Glu 305 310 315 320 Ala Gly Ser Pro Ala Met Ala Val Leu Asp Arg Gly Thr Ser Thr Thr 325 330 335 Thr Val Phe Asn Phe Pro Val Ser Ile Pro Val His Ser Thr Asn Ser 340 345 350 Ala Leu Ser Tyr Leu Gln Ser Pro Ile Thr Thr Ser Pro Ser Cys 355 360 365 <210> 294 <211> 201 <212> PRT <213> Homo sapiens <400> 294 Met Asp Leu Ser Leu Leu Trp Val Leu Met Pro Leu Val Thr Met Ala 1 5 10 15 Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 20 25 30 Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 35 40 45 Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 50 55 60 Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 65 70 75 80 Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 85 90 95 Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 100 105 110 Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 115 120 125 Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 130 135 140 Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 145 150 155 160 Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 165 170 175 Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 180 185 190 Glu Tyr Asp Cys Glu Phe Ala Asn Val 195 200 <210> 295 <211> 58 <212> PRT <213> Homo sapiens <400> 295 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Leu Ser Gly Ser Gly Gly Thr Arg 50 55 <210> 296 <211> 445 <212> PRT <213> Homo sapiens <400> 296 Met Ala Leu Val Asp Lys His Lys Val Lys Arg Gln Arg Leu Asp Arg 1 5 10 15 Ile Cys Glu Gly Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro 20 25 30 Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met 35 40 45 Pro Ile Leu Lys Asp Leu Ala Thr Val Ala Phe Cys Asp Ala Gln Ser 50 55 60 Thr Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met 65 70 75 80 Met Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys 85 90 95 Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asp 100 105 110 Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser 115 120 125 Ala Ala Val Glu Glu Thr Ala Asp Ser Thr Ile Cys His Ile Leu Asn 130 135 140 Leu Tyr Arg Arg Asn Thr Trp Leu Tyr Gln Ala Leu Arg Glu Gly Thr 145 150 155 160 Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala 165 170 175 Arg Ile Arg Gly Glu Thr Leu Gly Leu Ile Gly Phe Gly Arg Thr Gly 180 185 190 Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe 195 200 205 Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln 210 215 220 Arg Val Tyr Thr Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser 225 230 235 240 Leu His Cys Asn Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe 245 250 255 Thr Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg 260 265 270 Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly 275 280 285 Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser 290 295 300 Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro 305 310 315 320 His Thr Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala 325 330 335 Ala Ala Thr Glu Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Glu Ser 340 345 350 Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Thr Ser Ala Pro Trp 355 360 365 Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Thr 370 375 380 Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro 385 390 395 400 Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro Val Thr His Asn 405 410 415 Leu Pro Thr Val Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro 420 425 430 Thr Lys His Gly Asp Asn Arg Glu His Pro Asn Glu Gln 435 440 445 <210> 297 <211> 276 <212> PRT <213> Homo sapiens <400> 297 Met Asp Ser Ser Arg Glu Pro Thr Leu Gly Arg Leu Asp Ala Ala Gly 1 5 10 15 Phe Trp Gln Val Trp Arg Arg Phe Asp Ala Asp Glu Lys Gly Tyr Ile 20 25 30 Glu Glu Lys Glu Leu Asp Ala Phe Phe Leu His Met Leu Met Lys Leu 35 40 45 Gly Thr Asp Asp Thr Val Met Lys Ala Asn Leu His Lys Val Lys Gln 50 55 60 Gln Phe Met Thr Thr Gln Asp Ala Ser Lys Asp Gly Arg Ile Arg Met 65 70 75 80 Lys Glu Leu Ala Gly Met Phe Leu Ser Glu Asp Glu Asn Phe Leu Leu 85 90 95 Leu Phe Arg Arg Glu Asn Pro Leu Asp Ser Ser Val Glu Phe Met Gln 100 105 110 Ile Trp Arg Lys Tyr Asp Ala Asp Ser Ser Gly Phe Ile Ser Ala Ala 115 120 125 Glu Leu Arg Asn Phe Leu Arg Asp Leu Phe Leu His His Lys Lys Ala 130 135 140 Ile Ser Glu Ala Lys Leu Glu Glu Tyr Thr Gly Thr Met Met Lys Ile 145 150 155 160 Phe Asp Arg Asn Lys Asp Gly Arg Leu Asp Leu Asn Asp Leu Ala Arg 165 170 175 Ile Leu Ala Leu Gln Glu Asn Phe Leu Leu Gln Phe Lys Met Asp Ala 180 185 190 Cys Ser Thr Glu Glu Arg Lys Arg Asp Phe Glu Lys Ile Phe Ala Tyr 195 200 205 Tyr Asp Val Ser Lys Thr Gly Ala Leu Glu Gly Pro Glu Val Asp Gly 210 215 220 Phe Val Lys Asp Met Met Glu Leu Val Gln Pro Ser Ile Ser Gly Val 225 230 235 240 Asp Leu Asp Lys Phe Arg Glu Ile Leu Leu Arg His Cys Asp Val Asn 245 250 255 Lys Asp Gly Lys Ile Gln Lys Ser Glu Leu Ala Leu Cys Leu Gly Leu 260 265 270 Lys Ile Asn Pro 275 <210> 298 <211> 491 <212> PRT <213> Homo sapiens <400> 298 Met Val Phe Gly Glu Phe Phe His Arg Pro Gly Gln Asp Glu Glu Leu 1 5 10 15 Val Asn Leu Asn Val Gly Gly Phe Lys Gln Ser Val Asp Gln Ser Thr 20 25 30 Leu Leu Arg Phe Pro His Thr Arg Leu Gly Lys Leu Leu Thr Cys His 35 40 45 Ser Glu Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Ser Val Ala Asp 50 55 60 Lys Glu Tyr Tyr Phe Asp Arg Asn Pro Ser Leu Phe Arg Tyr Val Leu 65 70 75 80 Asn Phe Tyr Tyr Thr Gly Lys Leu His Val Met Glu Glu Leu Cys Val 85 90 95 Phe Ser Phe Cys Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu Leu Phe 100 105 110 Ile Asp Ser Cys Cys Ser Asn Arg Tyr Gln Glu Arg Lys Glu Glu Asn 115 120 125 His Glu Lys Asp Trp Asp Gln Lys Ser His Asp Val Ser Thr Asp Ser 130 135 140 Ser Phe Glu Glu Ser Ser Leu Phe Glu Lys Glu Leu Glu Lys Phe Asp 145 150 155 160 Thr Leu Arg Phe Gly Gln Leu Arg Lys Lys Ile Trp Ile Arg Met Glu 165 170 175 Asn Pro Ala Tyr Cys Leu Ser Ala Lys Leu Ile Ala Ile Ser Ser Leu 180 185 190 Ser Val Val Leu Ala Ser Ile Val Ala Met Cys Val His Ser Met Ser 195 200 205 Glu Phe Gln Asn Glu Asp Gly Glu Val Asp Asp Pro Val Leu Glu Gly 210 215 220 Val Glu Ile Ala Cys Ile Ala Trp Phe Thr Gly Glu Leu Ala Val Arg 225 230 235 240 Leu Ala Ala Ala Pro Cys Gln Lys Lys Phe Trp Lys Asn Pro Leu Asn 245 250 255 Ile Ile Asp Phe Val Ser Ile Ile Pro Phe Tyr Ala Thr Leu Ala Val 260 265 270 Asp Thr Lys Glu Glu Glu Ser Glu Asp Ile Glu Asn Met Gly Lys Val 275 280 285 Val Gln Ile Leu Arg Leu Met Arg Ile Phe Arg Ile Leu Lys Leu Ala 290 295 300 Arg His Ser Val Gly Leu Arg Ser Leu Gly Ala Thr Leu Arg His Ser 305 310 315 320 Tyr His Glu Val Gly Leu Leu Leu Leu Phe Leu Ser Val Gly Ile Ser 325 330 335 Ile Phe Ser Val Leu Ile Tyr Ser Val Glu Lys Asp Asp His Thr Ser 340 345 350 Ser Leu Thr Ser Ile Pro Ile Cys Trp Trp Trp Ala Thr Ile Ser Met 355 360 365 Thr Thr Val Gly Tyr Gly Asp Thr His Pro Val Thr Leu Ala Gly Lys 370 375 380 Leu Ile Ala Ser Thr Cys Ile Ile Cys Gly Ile Leu Val Val Ala Leu 385 390 395 400 Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser Lys Tyr Tyr Gln Lys Gln 405 410 415 Lys Asp Ile Asp Val Asp Gln Cys Ser Glu Asp Ala Pro Glu Lys Cys 420 425 430 His Glu Leu Pro Tyr Phe Asn Ile Arg Asp Ile Tyr Ala Gln Arg Met 435 440 445 His Ala Phe Ile Thr Ser Leu Ser Ser Val Gly Ile Val Val Ser Asp 450 455 460 Pro Asp Ser Thr Asp Ala Ser Ser Ile Glu Asp Asn Glu Asp Ile Cys 465 470 475 480 Asn Thr Thr Ser Leu Glu Asn Cys Thr Ala Lys 485 490 <210> 299 <211> 449 <212> PRT <213> Homo sapiens <400> 299 Asn Asn Glu Glu Ser Pro Thr Ala Thr Val Ala Glu Gln Gly Glu Asp 1 5 10 15 Ile Thr Ser Lys Lys Asp Arg Gly Val Leu Lys Ile Val Lys Arg Val 20 25 30 Gly Asn Gly Glu Glu Thr Pro Met Ile Gly Asp Lys Val Tyr Val His 35 40 45 Tyr Lys Gly Lys Leu Ser Asn Gly Lys Lys Phe Asp Ser Ser His Asp 50 55 60 Arg Asn Glu Pro Phe Val Phe Ser Leu Gly Lys Gly Gln Val Ile Lys 65 70 75 80 Ala Trp Asp Ile Gly Val Ala Thr Met Lys Lys Gly Glu Ile Cys His 85 90 95 Leu Leu Cys Lys Pro Glu Tyr Ala Tyr Gly Ser Ala Gly Ser Leu Pro 100 105 110 Lys Ile Pro Ser Asn Ala Thr Leu Phe Phe Glu Ile Glu Leu Leu Asp 115 120 125 Phe Lys Gly Glu Asp Leu Phe Glu Asp Gly Gly Ile Ile Arg Arg Thr 130 135 140 Lys Arg Lys Gly Glu Gly Tyr Ser Asn Pro Asn Glu Gly Ala Thr Val 145 150 155 160 Glu Ile His Leu Glu Gly Arg Cys Gly Gly Arg Met Phe Asp Cys Arg 165 170 175 Asp Val Ala Phe Thr Val Gly Glu Gly Glu Asp His Asp Ile Pro Ile 180 185 190 Gly Ile Asp Lys Ala Leu Glu Lys Met Gln Arg Glu Glu Gln Cys Ile 195 200 205 Leu Tyr Leu Gly Pro Arg Tyr Gly Phe Gly Glu Ala Gly Lys Pro Lys 210 215 220 Phe Gly Ile Glu Pro Asn Ala Glu Leu Ile Tyr Glu Val Thr Leu Lys 225 230 235 240 Ser Phe Glu Lys Ala Lys Glu Ser Trp Glu Met Asp Thr Lys Glu Lys 245 250 255 Leu Glu Gln Ala Ala Ile Val Lys Glu Lys Gly Thr Val Tyr Phe Lys 260 265 270 Gly Gly Lys Tyr Met Gln Ala Val Ile Gln Tyr Gly Lys Ile Val Ser 275 280 285 Trp Leu Glu Met Glu Tyr Gly Leu Ser Glu Lys Glu Ser Lys Ala Ser 290 295 300 Glu Ser Phe Leu Leu Ala Ala Phe Leu Asn Leu Ala Met Cys Tyr Leu 305 310 315 320 Lys Leu Arg Glu Tyr Thr Lys Ala Val Glu Cys Cys Asp Lys Ala Leu 325 330 335 Gly Leu Asp Ser Ala Asn Glu Lys Gly Leu Tyr Arg Arg Gly Glu Ala 340 345 350 Gln Leu Leu Met Asn Glu Phe Glu Ser Ala Lys Gly Asp Phe Glu Lys 355 360 365 Val Leu Glu Val Asn Pro Gln Asn Lys Ala Ala Arg Leu Gln Ile Ser 370 375 380 Met Cys Gln Lys Lys Ala Lys Glu His Asn Glu Arg Asp Arg Arg Ile 385 390 395 400 Tyr Ala Asn Met Phe Lys Lys Phe Ala Glu Gln Asp Ala Lys Glu Glu 405 410 415 Ala Asn Lys Ala Met Gly Lys Lys Thr Ser Glu Gly Val Thr Asn Glu 420 425 430 Lys Gly Thr Asp Ser Gln Ala Met Glu Glu Glu Lys Pro Glu Gly His 435 440 445 Val <210> 300 <211> 387 <212> PRT <213> Homo sapiens <400> 300 Met Ala Thr Ser Gly Val Leu Pro Gly Gly Gly Phe Val Ala Ser Ala 1 5 10 15 Ala Ala Val Ala Gly Pro Glu Met Gln Thr Gly Arg Asn Asn Phe Val 20 25 30 Ile Arg Arg Asn Pro Ala Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser 35 40 45 His Arg Ile Gln Cys Ala Ala Gly Tyr Glu Gln Ser Glu His Asn Val 50 55 60 Cys Gln Asp Ile Asp Glu Cys Thr Ala Gly Thr His Asn Cys Arg Ala 65 70 75 80 Asp Gln Val Cys Ile Asn Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro 85 90 95 Pro Gly Tyr Gln Lys Arg Gly Glu Gln Cys Val Asp Ile Asp Glu Cys 100 105 110 Thr Ile Pro Pro Tyr Cys His Gln Arg Cys Val Asn Thr Pro Gly Ser 115 120 125 Phe Tyr Cys Gln Cys Ser Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr 130 135 140 Thr Cys Val Asp Ile Asn Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln 145 150 155 160 Gln Cys Tyr Asn Ile Leu Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly 165 170 175 Tyr Glu Leu Ser Ser Asp Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys 180 185 190 Arg Thr Ser Ser Tyr Leu Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly 195 200 205 Lys Phe Ser Cys Met Cys Pro Gln Gly Tyr Gln Val Val Arg Ser Arg 210 215 220 Thr Cys Gln Asp Ile Asn Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu 225 230 235 240 Asp Glu Met Cys Trp Asn Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg 245 250 255 Asn Pro Cys Gln Asp Pro Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val 260 265 270 Cys Pro Val Ser Asn Ala Met Cys Arg Glu Leu Pro Gln Ser Ile Val 275 280 285 Tyr Lys Tyr Met Ser Ile Arg Ser Asp Arg Ser Val Pro Ser Asp Ile 290 295 300 Phe Gln Ile Gln Ala Thr Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe 305 310 315 320 Arg Ile Lys Ser Gly Asn Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr 325 330 335 Ser Pro Val Ser Ala Met Leu Val Leu Val Lys Ser Leu Ser Gly Pro 340 345 350 Arg Glu His Ile Val Asp Leu Glu Met Leu Thr Val Ser Ser Ile Gly 355 360 365 Thr Phe Arg Thr Ser Ser Val Leu Arg Leu Thr Ile Ile Val Gly Pro 370 375 380 Phe Ser Phe 385 <210> 301 <211> 843 <212> PRT <213> Homo sapiens <400> 301 Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 1 5 10 15 Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 20 25 30 Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 35 40 45 Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 50 55 60 Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 65 70 75 80 Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 85 90 95 Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 100 105 110 Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 115 120 125 Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 130 135 140 Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 145 150 155 160 Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 165 170 175 Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 180 185 190 Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 195 200 205 Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 210 215 220 Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 225 230 235 240 Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 245 250 255 Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 260 265 270 Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 275 280 285 Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 290 295 300 Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 305 310 315 320 Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 325 330 335 Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 340 345 350 Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 355 360 365 Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 370 375 380 Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 385 390 395 400 Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 405 410 415 Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 420 425 430 Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 435 440 445 Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 450 455 460 Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 465 470 475 480 Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 485 490 495 Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 500 505 510 Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 515 520 525 Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 530 535 540 Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 545 550 555 560 Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 565 570 575 Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Pro Met Phe Pro Val Gly 580 585 590 Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 595 600 605 Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 610 615 620 His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 625 630 635 640 Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 645 650 655 Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 660 665 670 Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 675 680 685 Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 690 695 700 Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 705 710 715 720 Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 725 730 735 Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 740 745 750 Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 755 760 765 Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 770 775 780 Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 785 790 795 800 Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 805 810 815 Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 820 825 830 Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 835 840 <210> 302 <211> 361 <212> PRT <213> Homo sapiens <400> 302 Met Asp Ile Gln Met Ala Asn Asn Phe Thr Pro Pro Ser Ala Thr Pro 1 5 10 15 Gln Gly Asn Asp Cys Asp Leu Tyr Ala His His Ser Thr Ala Arg Ile 20 25 30 Val Met Pro Leu His Tyr Ser Leu Val Phe Ile Ile Gly Leu Val Gly 35 40 45 Asn Leu Leu Ala Leu Val Val Ile Val Gln Asn Arg Lys Lys Ile Asn 50 55 60 Ser Thr Thr Leu Tyr Ser Thr Asn Leu Val Ile Ser Asp Ile Leu Phe 65 70 75 80 Thr Thr Ala Leu Pro Thr Arg Ile Ala Tyr Tyr Ala Met Gly Phe Asp 85 90 95 Trp Arg Ile Gly Asp Ala Leu Cys Arg Ile Thr Ala Leu Val Phe Tyr 100 105 110 Ile Asn Thr Tyr Ala Gly Val Asn Phe Met Thr Cys Leu Ser Ile Asp 115 120 125 Arg Phe Ile Ala Val Val His Pro Leu Arg Tyr Asn Lys Ile Lys Arg 130 135 140 Ile Glu His Ala Lys Gly Val Cys Ile Phe Val Trp Ile Leu Val Phe 145 150 155 160 Ala Gln Thr Leu Pro Leu Leu Ile Asn Pro Met Ser Lys Gln Glu Ala 165 170 175 Glu Arg Ile Thr Cys Met Glu Tyr Pro Asn Phe Glu Glu Thr Lys Ser 180 185 190 Leu Pro Trp Ile Leu Leu Gly Ala Cys Phe Ile Gly Tyr Val Leu Pro 195 200 205 Leu Ile Ile Ile Leu Ile Cys Tyr Ser Gln Ile Cys Cys Lys Leu Phe 210 215 220 Arg Thr Ala Lys Gln Asn Pro Leu Thr Glu Lys Ser Gly Val Asn Lys 225 230 235 240 Lys Ala Leu Asn Thr Ile Ile Leu Ile Ile Val Val Phe Val Leu Cys 245 250 255 Phe Thr Pro Tyr His Val Ala Ile Ile Gln His Met Ile Lys Lys Leu 260 265 270 Arg Phe Ser Asn Phe Leu Glu Cys Ser Gln Arg His Ser Phe Gln Ile 275 280 285 Ser Leu His Phe Thr Val Cys Leu Met Asn Phe Asn Cys Cys Met Asp 290 295 300 Pro Phe Ile Tyr Phe Phe Ala Cys Lys Gly Tyr Lys Arg Lys Val Met 305 310 315 320 Arg Met Leu Lys Arg Gln Val Ser Val Ser Ile Ser Ser Ala Val Lys 325 330 335 Ser Ala Pro Glu Glu Asn Ser Arg Glu Met Thr Glu Thr Gln Met Met 340 345 350 Ile His Ser Lys Ser Ser Asn Gly Lys 355 360 <210> 303 <211> 196 <212> PRT <213> Homo sapiens <400> 303 Met Pro Gly Met Phe Phe Ser Ala Asn Pro Lys Glu Leu Lys Gly Thr 1 5 10 15 Thr His Ser Leu Leu Asp Asp Lys Met Gln Lys Arg Arg Pro Lys Thr 20 25 30 Phe Gly Met Asp Met Lys Ala Tyr Leu Arg Ser Met Ile Pro His Leu 35 40 45 Glu Ser Gly Met Lys Ser Ser Lys Ser Lys Asp Val Leu Ser Ala Ala 50 55 60 Glu Val Met Gln Trp Ser Gln Ser Leu Glu Lys Leu Leu Ala Asn Gln 65 70 75 80 Thr Gly Gln Asn Val Phe Gly Ser Phe Leu Lys Ser Glu Phe Ser Glu 85 90 95 Glu Asn Ile Glu Phe Trp Leu Ala Cys Glu Asp Tyr Lys Lys Thr Glu 100 105 110 Ser Asp Leu Leu Pro Cys Lys Ala Glu Glu Ile Tyr Lys Ala Phe Val 115 120 125 His Ser Asp Ala Ala Lys Gln Ile Asn Ile Asp Phe Arg Thr Arg Glu 130 135 140 Ser Thr Ala Lys Lys Ile Lys Ala Pro Thr Pro Thr Cys Phe Asp Glu 145 150 155 160 Ala Gln Lys Val Ile Tyr Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg 165 170 175 Phe Leu Lys Ser Asp Ile Tyr Leu Asn Leu Leu Asn Asp Leu Gln Ala 180 185 190 Asn Ser Leu Lys 195 <210> 304 <211> 384 <212> PRT <213> Homo sapiens <400> 304 Met Ala Val Tyr Tyr Cys Val Ser Gly Gly Ile Tyr Asp Ser Ser Gly 1 5 10 15 Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 20 25 30 Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln 35 40 45 Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro 50 55 60 Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr 65 70 75 80 Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr 85 90 95 Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys 100 105 110 Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val 115 120 125 Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 130 135 140 Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu 145 150 155 160 His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu 165 170 175 Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr 180 185 190 Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg 195 200 205 Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala 210 215 220 Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro 225 230 235 240 Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr 245 250 255 Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala 260 265 270 Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro 275 280 285 Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg 290 295 300 Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr 305 310 315 320 Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp 325 330 335 Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro 340 345 350 Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr 355 360 365 His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 370 375 380 <210> 305 <211> 2466 <212> PRT <213> Homo sapiens <400> 305 Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu 1 5 10 15 Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu 20 25 30 Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly 35 40 45 Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val 50 55 60 Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr 65 70 75 80 Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val 85 90 95 Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala 100 105 110 Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu 115 120 125 Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val 130 135 140 Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser 145 150 155 160 Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val 165 170 175 Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln 180 185 190 Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly 195 200 205 Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys 210 215 220 Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser 225 230 235 240 Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys 245 250 255 Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe 260 265 270 Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro 275 280 285 Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp 290 295 300 Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr 305 310 315 320 Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr 325 330 335 Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp 340 345 350 Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu 355 360 365 Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg 370 375 380 Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro 385 390 395 400 Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser 405 410 415 Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg 420 425 430 Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly 435 440 445 Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln 450 455 460 Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu 465 470 475 480 Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu 485 490 495 Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser 500 505 510 Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr 515 520 525 Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val 530 535 540 Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile 545 550 555 560 Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile 565 570 575 Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr 580 585 590 Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val 595 600 605 Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe 610 615 620 Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp 625 630 635 640 Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu 645 650 655 Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His 660 665 670 Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu 675 680 685 Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser 690 695 700 Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly 705 710 715 720 Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu 725 730 735 Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn 740 745 750 Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys 755 760 765 Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His 770 775 780 Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys 785 790 795 800 Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu 805 810 815 Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys 820 825 830 Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr 835 840 845 Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln 850 855 860 His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala 865 870 875 880 Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu 885 890 895 Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu 900 905 910 Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln 915 920 925 Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln 930 935 940 Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu 945 950 955 960 Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala 965 970 975 Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro 980 985 990 Pro Gln Thr Val Ala Glu Leu Val Gly Lys Pro Ser His Gln Met Ser 995 1000 1005 Arg Ser Asp Ala Glu Ser Leu Ala Gly Val Thr Lys Leu Asn Asn Ser 1010 1015 1020 Lys Ser Val Ala Ser Leu Asn Arg Ser Pro Glu Arg Arg Lys His Glu 1025 1030 1035 1040 Ser Asp Ser Ser Ser Ile Glu Asp Pro Gly Gln Ala Tyr Val Leu Asp 1045 1050 1055 Val Leu His Lys Arg Trp Ser Ile Val Ser Ser Pro Glu Arg Glu Ile 1060 1065 1070 Thr Leu Val Asn Leu Lys Lys Asp Ala Lys Tyr Gly Leu Gly Phe Gln 1075 1080 1085 Ile Ile Gly Gly Glu Lys Met Gly Arg Leu Asp Leu Gly Ile Phe Ile 1090 1095 1100 Ser Ser Val Ala Pro Gly Gly Pro Ala Asp Leu Asp Gly Cys Leu Lys 1105 1110 1115 1120 Pro Gly Asp Arg Leu Ile Ser Val Asn Ser Val Ser Leu Glu Gly Val 1125 1130 1135 Ser His His Ala Ala Ile Glu Ile Leu Gln Asn Ala Pro Glu Asp Val 1140 1145 1150 Thr Leu Val Ile Ser Gln Pro Lys Glu Lys Ile Ser Lys Val Pro Ser 1155 1160 1165 Thr Pro Val His Leu Thr Asn Glu Met Lys Asn Tyr Met Lys Lys Ser 1170 1175 1180 Ser Tyr Met Gln Asp Ser Ala Ile Asp Ser Ser Ser Lys Asp His His 1185 1190 1195 1200 Trp Ser Arg Gly Thr Leu Arg His Ile Ser Glu Asn Ser Phe Gly Pro 1205 1210 1215 Ser Gly Gly Leu Arg Glu Gly Ser Leu Ser Ser Gln Asp Ser Arg Thr 1220 1225 1230 Glu Ser Ala Ser Leu Ser Gln Ser Gln Val Asn Gly Phe Phe Ala Ser 1235 1240 1245 His Leu Gly Asp Gln Thr Trp Gln Glu Ser Gln His Gly Ser Pro Ser 1250 1255 1260 Pro Ser Val Ile Ser Lys Ala Thr Glu Lys Glu Thr Phe Thr Asp Ser 1265 1270 1275 1280 Asn Gln Ser Lys Thr Lys Lys Pro Gly Ile Ser Asp Val Thr Asp Tyr 1285 1290 1295 Ser Asp Arg Gly Asp Ser Asp Met Asp Glu Ala Thr Tyr Ser Ser Ser 1300 1305 1310 Gln Asp His Gln Thr Pro Lys Gln Glu Ser Ser Ser Ser Val Asn Thr 1315 1320 1325 Ser Asn Lys Met Asn Phe Lys Thr Phe Ser Ser Ser Pro Pro Lys Pro 1330 1335 1340 Gly Asp Ile Phe Glu Val Glu Leu Ala Lys Asn Asp Asn Ser Leu Gly 1345 1350 1355 1360 Ile Ser Val Thr Gly Gly Val Asn Thr Ser Val Arg His Gly Gly Ile 1365 1370 1375 Tyr Val Lys Ala Val Ile Pro Gln Gly Ala Ala Glu Ser Asp Gly Arg 1380 1385 1390 Ile His Lys Gly Asp Arg Val Leu Ala Val Asn Gly Val Ser Leu Glu 1395 1400 1405 Gly Ala Thr His Lys Gln Ala Val Glu Thr Leu Arg Asn Thr Gly Gln 1410 1415 1420 Val Val His Leu Leu Leu Glu Lys Gly Gln Ser Pro Thr Ser Lys Glu 1425 1430 1435 1440 His Val Pro Val Thr Pro Gln Cys Thr Leu Ser Asp Gln Asn Ala Gln 1445 1450 1455 Gly Gln Gly Pro Glu Lys Val Lys Lys Thr Thr Gln Val Lys Asp Tyr 1460 1465 1470 Ser Phe Val Thr Glu Glu Asn Thr Phe Glu Val Lys Leu Phe Lys Asn 1475 1480 1485 Ser Ser Gly Leu Gly Phe Ser Phe Ser Arg Glu Asp Asn Leu Ile Pro 1490 1495 1500 Glu Gln Ile Asn Ala Ser Ile Val Arg Val Lys Lys Leu Phe Pro Gly 1505 1510 1515 1520 Gln Pro Ala Ala Glu Ser Gly Lys Ile Asp Val Gly Asp Val Ile Leu 1525 1530 1535 Lys Val Asn Gly Ala Ser Leu Lys Gly Leu Ser Gln Gln Glu Val Ile 1540 1545 1550 Ser Ala Leu Arg Gly Thr Ala Pro Glu Val Phe Leu Leu Leu Cys Arg 1555 1560 1565 Pro Pro Pro Gly Val Leu Pro Glu Ile Asp Thr Ala Leu Leu Thr Pro 1570 1575 1580 Leu Gln Ser Pro Ala Gln Val Leu Pro Asn Ser Ser Lys Asp Ser Ser 1585 1590 1595 1600 Gln Pro Ser Cys Val Glu Gln Ser Thr Ser Ser Asp Glu Asn Glu Met 1605 1610 1615 Ser Asp Lys Ser Lys Lys Gln Cys Lys Ser Pro Ser Arg Arg Asp Ser 1620 1625 1630 Tyr Ser Asp Ser Ser Gly Ser Gly Glu Asp Asp Leu Val Thr Ala Pro 1635 1640 1645 Ala Asn Ile Ser Asn Ser Thr Trp Ser Ser Ala Leu His Gln Thr Leu 1650 1655 1660 Ser Asn Met Val Ser Gln Ala Gln Ser His His Glu Ala Pro Lys Ser 1665 1670 1675 1680 Gln Glu Asp Thr Ile Cys Thr Met Phe Tyr Tyr Pro Gln Lys Ile Pro 1685 1690 1695 Asn Lys Pro Glu Phe Glu Asp Ser Asn Pro Ser Pro Leu Pro Pro Asp 1700 1705 1710 Met Ala Pro Gly Gln Ser Tyr Gln Pro Gln Ser Glu Ser Ala Ser Ser 1715 1720 1725 Ser Ser Met Asp Lys Tyr His Ile His His Ile Ser Glu Pro Thr Arg 1730 1735 1740 Gln Glu Asn Trp Thr Pro Leu Lys Asn Asp Leu Glu Asn His Leu Glu 1745 1750 1755 1760 Asp Phe Glu Leu Glu Val Glu Leu Leu Ile Thr Leu Ile Lys Ser Glu 1765 1770 1775 Lys Gly Ser Leu Gly Phe Thr Val Thr Lys Gly Asn Gln Arg Ile Gly 1780 1785 1790 Cys Tyr Val His Asp Val Ile Gln Asp Pro Ala Lys Ser Asp Gly Arg 1795 1800 1805 Leu Lys Pro Gly Asp Arg Leu Ile Lys Val Asn Asp Thr Asp Val Thr 1810 1815 1820 Asn Met Thr His Thr Asp Ala Val Asn Leu Leu Arg Ala Ala Ser Lys 1825 1830 1835 1840 Thr Val Arg Leu Val Ile Gly Arg Val Leu Glu Leu Pro Arg Ile Pro 1845 1850 1855 Met Leu Pro His Leu Leu Pro Asp Ile Thr Leu Thr Cys Asn Lys Glu 1860 1865 1870 Glu Leu Gly Phe Ser Leu Cys Gly Gly His Asp Ser Leu Tyr Gln Val 1875 1880 1885 Val Tyr Ile Ser Asp Ile Asn Pro Arg Ser Val Ala Ala Ile Glu Gly 1890 1895 1900 Asn Leu Gln Leu Leu Asp Val Ile His Tyr Val Asn Gly Val Ser Thr 1905 1910 1915 1920 Gln Gly Met Thr Leu Glu Glu Val Asn Arg Ala Leu Asp Met Ser Leu 1925 1930 1935 Pro Ser Leu Val Leu Lys Ala Thr Arg Asn Asp Leu Pro Val Val Pro 1940 1945 1950 Ser Ser Lys Arg Ser Ala Val Ser Ala Pro Lys Ser Thr Lys Gly Asn 1955 1960 1965 Gly Ser Tyr Ser Val Gly Ser Cys Ser Gln Pro Ala Leu Thr Pro Asn 1970 1975 1980 Asp Ser Phe Ser Thr Val Ala Gly Glu Glu Ile Asn Glu Ile Ser Tyr 1985 1990 1995 2000 Pro Lys Gly Lys Cys Ser Thr Tyr Gln Ile Lys Gly Ser Pro Asn Leu 2005 2010 2015 Thr Leu Pro Lys Glu Ser Tyr Ile Gln Glu Asp Asp Ile Tyr Asp Asp 2020 2025 2030 Ser Gln Glu Ala Glu Val Ile Gln Ser Leu Leu Asp Val Val Asp Glu 2035 2040 2045 Glu Ala Gln Asn Leu Leu Asn Glu Asn Asn Ala Ala Gly Tyr Ser Cys 2050 2055 2060 Gly Pro Gly Thr Leu Lys Met Asn Gly Lys Leu Ser Glu Glu Arg Thr 2065 2070 2075 2080 Glu Asp Thr Asp Cys Asp Gly Ser Pro Leu Pro Glu Tyr Phe Thr Glu 2085 2090 2095 Ala Thr Lys Met Asn Gly Cys Glu Glu Tyr Cys Glu Glu Lys Val Lys 2100 2105 2110 Ser Glu Ser Leu Ile Gln Lys Pro Gln Glu Lys Lys Thr Asp Asp Asp 2115 2120 2125 Glu Ile Thr Trp Gly Asn Asp Glu Leu Pro Ile Glu Arg Thr Asn His 2130 2135 2140 Glu Asp Ser Asp Lys Asp His Ser Phe Leu Thr Asn Asp Glu Leu Ala 2145 2150 2155 2160 Val Leu Pro Val Val Lys Val Leu Pro Ser Gly Lys Tyr Thr Gly Ala 2165 2170 2175 Asn Leu Lys Ser Val Ile Arg Val Leu Arg Gly Leu Leu Asp Gln Gly 2180 2185 2190 Ile Pro Ser Lys Glu Leu Glu Asn Leu Gln Glu Leu Lys Pro Leu Asp 2195 2200 2205 Gln Cys Leu Ile Gly Gln Thr Lys Glu Asn Arg Arg Lys Asn Arg Tyr 2210 2215 2220 Lys Asn Ile Leu Pro Tyr Asp Ala Thr Arg Val Pro Leu Gly Asp Glu 2225 2230 2235 2240 Gly Gly Tyr Ile Asn Ala Ser Phe Ile Lys Ile Pro Val Gly Lys Glu 2245 2250 2255 Glu Phe Val Tyr Ile Ala Cys Gln Gly Pro Leu Pro Thr Thr Val Gly 2260 2265 2270 Asp Phe Trp Gln Met Ile Trp Glu Gln Lys Ser Thr Val Ile Ala Met 2275 2280 2285 Met Thr Gln Glu Val Glu Gly Glu Lys Ile Lys Cys Gln Arg Tyr Trp 2290 2295 2300 Pro Asn Ile Leu Gly Lys Thr Thr Met Val Ser Asn Arg Leu Arg Leu 2305 2310 2315 2320 Ala Leu Val Arg Met Gln Gln Leu Lys Gly Phe Val Val Arg Ala Met 2325 2330 2335 Thr Leu Glu Asp Ile Gln Thr Arg Glu Val Arg His Ile Ser His Leu 2340 2345 2350 Asn Phe Thr Ala Trp Pro Asp His Asp Thr Pro Ser Gln Pro Asp Asp 2355 2360 2365 Leu Leu Thr Phe Ile Ser Tyr Met Arg His Ile His Arg Ser Gly Pro 2370 2375 2380 Ile Ile Thr His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr Leu Ile 2385 2390 2395 2400 Cys Ile Asp Val Val Leu Gly Leu Ile Ser Gln Asp Leu Asp Phe Asp 2405 2410 2415 Ile Ser Asp Leu Val Arg Cys Met Arg Leu Gln Arg His Gly Met Val 2420 2425 2430 Gln Thr Glu Asp Gln Tyr Ile Phe Cys Tyr Gln Val Ile Leu Tyr Val 2435 2440 2445 Leu Thr Arg Leu Gln Ala Glu Glu Glu Gln Lys Gln Gln Pro Gln Leu 2450 2455 2460 Leu Lys 2465 <210> 306 <211> 531 <212> PRT <213> Homo sapiens <400> 306 Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 1 5 10 15 Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 20 25 30 Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 35 40 45 Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 50 55 60 Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 65 70 75 80 His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 85 90 95 Ser Phe Ala Ser Asp Pro Tyr Leu Tyr Arg Pro Val Ala Val Ala Leu 100 105 110 Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 115 120 125 Thr Ala Glu Leu Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 130 135 140 Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 145 150 155 160 Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 165 170 175 Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 180 185 190 Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 195 200 205 Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 210 215 220 Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 225 230 235 240 Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 245 250 255 Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 260 265 270 Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 275 280 285 Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 290 295 300 Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 305 310 315 320 Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 325 330 335 Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 340 345 350 Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 355 360 365 Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 370 375 380 Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 385 390 395 400 Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 405 410 415 Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 420 425 430 Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 435 440 445 Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 450 455 460 Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 465 470 475 480 Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 485 490 495 Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 500 505 510 Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 515 520 525 Pro Val Pro 530 <210> 307 <211> 3703 <212> PRT <213> Homo sapiens <400> 307 Met Glu Gly Cys Asp Ser Pro Val Val Ser Gly Lys Asp Asn Gly Cys 1 5 10 15 Gly Ile Pro Gln His Gln Gln Trp Thr Glu Leu Asn Ser Thr His Leu 20 25 30 Pro Asp Lys Pro Ser Ser Met Glu Gln Ser Thr Gly Glu Ser His Gly 35 40 45 Pro Leu Asp Ser Leu Arg Ala Pro Phe Asn Glu Arg Leu Ala Glu Ser 50 55 60 Thr Ala Ser Ala Gly Pro Pro Ala Glu Pro Ala Ser Lys Glu Val Thr 65 70 75 80 Cys Asn Glu Cys Ser Ala Ser Phe Ala Ser Leu Gln Thr Tyr Met Glu 85 90 95 His His Cys Pro Ser Ala Arg Pro Pro Pro Pro Leu Arg Glu Glu Ser 100 105 110 Ala Ser Asp Thr Gly Glu Glu Gly Asp Glu Glu Ser Asp Val Glu Asn 115 120 125 Leu Ala Gly Glu Ile Val Tyr Gln Pro Asp Gly Ser Ala Tyr Ile Val 130 135 140 Glu Ser Leu Ser Gln Leu Thr Gln Gly Gly Gly Ala Cys Gly Ser Gly 145 150 155 160 Ser Gly Ser Gly Pro Leu Pro Ser Leu Phe Leu Asn Ser Leu Pro Gly 165 170 175 Ala Gly Gly Lys Gln Gly Asp Pro Ser Cys Ala Ala Pro Val Tyr Pro 180 185 190 Gln Ile Ile Asn Thr Phe His Ile Ala Ser Ser Phe Gly Lys Trp Phe 195 200 205 Glu Gly Pro Asp Gln Ala Phe Pro Asn Thr Ser Ala Leu Ala Gly Leu 210 215 220 Ser Pro Val Leu His Ser Phe Arg Val Phe Asp Val Arg His Lys Ser 225 230 235 240 Asn Lys Asp Tyr Leu Asn Ser Asp Gly Ser Ala Lys Ser Ser Cys Val 245 250 255 Ser Lys Asp Val Pro Asn Asn Val Asp Leu Ser Lys Phe Asp Gly Phe 260 265 270 Val Leu Tyr Gly Lys Arg Lys Pro Ile Leu Met Cys Phe Leu Cys Lys 275 280 285 Leu Ser Phe Gly Tyr Val Arg Ser Phe Val Thr His Ala Val His Asp 290 295 300 His Arg Met Thr Leu Ser Glu Asp Glu Arg Lys Ile Leu Ser Asn Lys 305 310 315 320 Asn Ile Ser Ala Ile Ile Gln Gly Ile Gly Lys Asp Lys Glu Pro Leu 325 330 335 Val Ser Phe Leu Glu Pro Lys Asn Lys Asn Phe Gln His Pro Leu Val 340 345 350 Ser Thr Ala Asn Leu Ile Gly Pro Gly His Ser Phe Tyr Gly Lys Phe 355 360 365 Ser Gly Ile Arg Met Glu Gly Glu Glu Ala Leu Pro Ala Gly Ser Ala 370 375 380 Ala Gly Pro Glu Gln Pro Gln Ala Gly Leu Leu Thr Pro Ser Thr Leu 385 390 395 400 Leu Asn Leu Gly Gly Leu Thr Ser Ser Val Leu Lys Thr Pro Ile Thr 405 410 415 Ser Val Pro Leu Gly Ala Leu Ala Ser Ser Pro Thr Lys Ser Ser Glu 420 425 430 Gly Lys Asp Ser Gly Ala Ala Glu Gly Glu Lys Gln Glu Val Gly Asp 435 440 445 Gly Asp Cys Phe Ser Glu Lys Val Glu Pro Ala Glu Glu Glu Ala Glu 450 455 460 Glu Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Glu 465 470 475 480 Glu Glu Glu Glu Glu Glu Glu Asp Glu Gly Cys Lys Gly Leu Phe Pro 485 490 495 Ser Glu Leu Asp Glu Glu Leu Glu Asp Arg Pro His Glu Glu Pro Gly 500 505 510 Ala Ala Ala Gly Ser Ser Ser Lys Lys Asp Leu Ala Leu Ser Asn Gln 515 520 525 Ser Ile Ser Asn Ser Pro Leu Met Pro Asn Val Leu Gln Thr Leu Ser 530 535 540 Arg Gly Thr Ala Ser Thr Ser Ser Asn Ser Ala Ser Ser Phe Val Val 545 550 555 560 Phe Asp Gly Ala Asn Arg Arg Asn Arg Leu Ser Phe Asn Ser Glu Gly 565 570 575 Val Arg Thr Asn Val Ala Glu Gly Gly Arg Arg Leu Asp Phe Ala Asp 580 585 590 Glu Ser Ala Asn Lys Asp Asn Ala Thr Ala Pro Glu Pro Asn Glu Ser 595 600 605 Thr Glu Gly Asp Asp Gly Gly Phe Val Pro His His Gln His Ala Gly 610 615 620 Ser Leu Cys Glu Leu Gly Val Gly Glu Cys Pro Ser Gly Ser Gly Val 625 630 635 640 Glu Cys Pro Lys Cys Asp Thr Val Leu Gly Ser Ser Arg Ser Leu Gly 645 650 655 Gly His Met Thr Met Met His Ser Arg Asn Ser Cys Lys Thr Leu Lys 660 665 670 Cys Pro Lys Cys Asn Trp His Tyr Lys Tyr Gln Gln Thr Leu Glu Ala 675 680 685 His Met Lys Glu Lys His Pro Glu Pro Gly Gly Ser Cys Val Tyr Cys 690 695 700 Lys Ser Gly Gln Pro His Pro Arg Leu Ala Arg Gly Glu Ser Tyr Thr 705 710 715 720 Cys Gly Tyr Lys Pro Phe Arg Cys Glu Val Cys Asn Tyr Ser Thr Thr 725 730 735 Thr Lys Gly Asn Leu Ser Ile His Met Gln Ser Asp Lys His Leu Asn 740 745 750 Asn Met Gln Asn Leu Gln Asn Gly Gly Gly Glu Gln Val Phe Ile His 755 760 765 Thr Ala Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 770 775 780 Asn Ile Ser Ser Ser Cys Gly Ala Pro Ser Pro Thr Lys Pro Lys Thr 785 790 795 800 Lys Pro Thr Trp Arg Cys Glu Val Cys Asp Tyr Glu Thr Asn Val Ala 805 810 815 Arg Asn Leu Arg Ile His Met Thr Ser Glu Lys His Met His Asn Met 820 825 830 Met Leu Leu Gln Gln Asn Met Thr Gln Ile Gln His Asn His His Arg 835 840 845 Val Leu Gly Ser Leu Pro Ser Pro Ala Glu Ala Glu Leu Tyr Gln Tyr 850 855 860 Tyr Leu Ala Gln Asn Met Asn Leu Pro Asn Leu Lys Met Asp Ser Ala 865 870 875 880 Ala Ser Asp Ala Gln Phe Met Met Ser Gly Phe Gln Leu Asp Pro Ala 885 890 895 Gly Pro Met Ala Ala Met Thr Pro Ala Leu Val Gly Gly Glu Ile Pro 900 905 910 Leu Asp Met Arg Leu Gly Gly Gly Gln Leu Val Ser Glu Glu Leu Met 915 920 925 Asn Leu Gly Glu Ser Phe Ile Gln Thr Asn Asp Pro Ser Leu Lys Leu 930 935 940 Phe Gln Cys Ala Val Cys Asn Lys Phe Thr Thr Asp Asn Leu Asp Met 945 950 955 960 Leu Gly Leu His Met Asn Val Glu Arg Ser Leu Ser Glu Asp Glu Trp 965 970 975 Lys Ala Val Met Gly Asp Ser Tyr Gln Cys Lys Leu Cys Arg Tyr Asn 980 985 990 Thr Gln Leu Lys Ala Asn Phe Gln Leu His Cys Lys Thr Asp Lys His 995 1000 1005 Val Gln Lys Tyr Gln Leu Val Ala His Ile Lys Glu Gly Gly Lys Ala 1010 1015 1020 Asn Glu Trp Arg Leu Lys Cys Val Ala Ile Gly Asn Pro Val His Leu 1025 1030 1035 1040 Lys Cys Asn Ala Cys Asp Tyr Tyr Thr Asn Ser Leu Glu Lys Leu Arg 1045 1050 1055 Leu His Thr Val Asn Ser Arg His Glu Ala Ser Leu Lys Leu Tyr Lys 1060 1065 1070 His Leu Gln Gln His Glu Ser Gly Val Glu Gly Glu Ser Cys Tyr Tyr 1075 1080 1085 His Cys Val Leu Cys Asn Tyr Ser Thr Lys Ala Lys Leu Asn Leu Ile 1090 1095 1100 Gln His Val Arg Ser Met Lys His Gln Arg Ser Glu Ser Leu Arg Lys 1105 1110 1115 1120 Leu Gln Arg Leu Gln Lys Gly Leu Pro Glu Glu Asp Glu Asp Leu Gly 1125 1130 1135 Gln Ile Phe Thr Ile Arg Arg Cys Pro Ser Thr Asp Pro Glu Glu Ala 1140 1145 1150 Ile Glu Asp Val Glu Gly Pro Ser Glu Thr Ala Ala Asp Pro Glu Glu 1155 1160 1165 Leu Ala Lys Asp Gln Glu Gly Gly Ala Ser Ser Ser Gln Ala Glu Lys 1170 1175 1180 Glu Leu Thr Asp Ser Pro Ala Thr Ser Lys Arg Ile Ser Phe Pro Gly 1185 1190 1195 1200 Ser Ser Glu Ser Pro Leu Ser Ser Lys Arg Pro Lys Thr Ala Glu Glu 1205 1210 1215 Ile Lys Pro Glu Gln Met Tyr Gln Cys Pro Tyr Cys Lys Tyr Ser Asn 1220 1225 1230 Ala Asp Val Asn Arg Leu Arg Val His Ala Met Thr Gln His Ser Val 1235 1240 1245 Gln Pro Met Leu Arg Cys Pro Leu Cys Gln Asp Met Leu Asn Asn Lys 1250 1255 1260 Ile His Leu Gln Leu His Leu Thr His Leu His Ser Val Ala Pro Asp 1265 1270 1275 1280 Cys Val Glu Lys Leu Ile Met Thr Val Thr Thr Pro Glu Met Val Met 1285 1290 1295 Pro Ser Ser Met Phe Leu Pro Ala Ala Val Pro Asp Arg Asp Gly Asn 1300 1305 1310 Ser Asn Leu Glu Glu Ala Gly Lys Gln Pro Glu Thr Ser Glu Asp Leu 1315 1320 1325 Gly Lys Asn Ile Leu Pro Ser Ala Ser Thr Glu Gln Ser Gly Asp Leu 1330 1335 1340 Lys Pro Ser Pro Ala Asp Pro Gly Ser Val Arg Glu Asp Ser Gly Phe 1345 1350 1355 1360 Ile Cys Trp Lys Lys Gly Cys Asn Gln Val Phe Lys Thr Ser Ala Ala 1365 1370 1375 Leu Gln Thr His Phe Asn Glu Val His Ala Lys Arg Pro Gln Leu Pro 1380 1385 1390 Val Ser Asp Arg His Val Tyr Lys Tyr Arg Cys Asn Gln Cys Ser Leu 1395 1400 1405 Ala Phe Lys Thr Ile Glu Lys Leu Gln Leu His Ser Gln Tyr His Val 1410 1415 1420 Ile Arg Ala Ala Thr Met Cys Cys Leu Cys Gln Arg Ser Phe Arg Thr 1425 1430 1435 1440 Phe Gln Ala Leu Lys Lys His Leu Glu Thr Ser His Leu Glu Leu Ser 1445 1450 1455 Glu Ala Asp Ile Gln Gln Leu Tyr Gly Gly Leu Leu Ala Asn Gly Asp 1460 1465 1470 Leu Leu Ala Met Gly Asp Pro Thr Leu Ala Glu Asp His Thr Ile Ile 1475 1480 1485 Val Glu Glu Asp Lys Glu Glu Glu Ser Asp Leu Glu Asp Lys Gln Ser 1490 1495 1500 Pro Thr Gly Ser Asp Ser Gly Ser Val Gln Glu Asp Ser Gly Ser Glu 1505 1510 1515 1520 Pro Lys Arg Ala Leu Pro Phe Arg Lys Gly Pro Asn Phe Thr Met Glu 1525 1530 1535 Lys Phe Leu Asp Pro Ser Arg Pro Tyr Lys Cys Thr Val Cys Lys Glu 1540 1545 1550 Ser Phe Thr Gln Lys Asn Ile Leu Leu Val His Tyr Asn Ser Val Ser 1555 1560 1565 His Leu His Lys Leu Lys Arg Ala Leu Gln Glu Ser Ala Thr Gly Gln 1570 1575 1580 Pro Glu Pro Thr Ser Ser Pro Asp Asn Lys Pro Phe Lys Cys Asn Thr 1585 1590 1595 1600 Cys Asn Val Ala Tyr Ser Gln Ser Ser Thr Leu Glu Ile His Met Arg 1605 1610 1615 Ser Val Leu His Gln Thr Lys Ala Arg Ala Ala Lys Leu Glu Ala Ala 1620 1625 1630 Ser Gly Ser Ser Asn Gly Thr Gly Asn Ser Ser Ser Ile Ser Leu Ser 1635 1640 1645 Ser Ser Thr Pro Ser Pro Val Ser Thr Ser Gly Ser Asn Thr Phe Thr 1650 1655 1660 Thr Ser Asn Pro Ser Ser Ala Gly Ile Ala Pro Ser Ser Asn Leu Leu 1665 1670 1675 1680 Ser Gln Val Pro Thr Glu Ser Val Gly Met Pro Pro Leu Gly Asn Pro 1685 1690 1695 Ile Gly Ala Asn Ile Ala Ser Pro Ser Glu Pro Lys Glu Ala Asn Arg 1700 1705 1710 Lys Lys Leu Ala Asp Met Ile Ala Ser Arg Gln Gln Gln Gln Gln Gln 1715 1720 1725 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Gln Thr 1730 1735 1740 Leu Ala Gln Ala Gln Ala Gln Val Gln Ala His Leu Gln Gln Glu Leu 1745 1750 1755 1760 Gln Gln Gln Ala Ala Leu Ile Gln Ser Gln Leu Phe Asn Pro Thr Leu 1765 1770 1775 Leu Pro His Phe Pro Met Thr Thr Glu Thr Leu Leu Gln Leu Gln Gln 1780 1785 1790 Gln Gln His Leu Leu Phe Pro Phe Tyr Ile Pro Ser Ala Glu Phe Gln 1795 1800 1805 Leu Asn Pro Glu Val Ser Leu Pro Val Thr Ser Gly Ala Leu Thr Leu 1810 1815 1820 Thr Gly Thr Gly Pro Gly Leu Leu Glu Asp Leu Lys Ala Gln Val Gln 1825 1830 1835 1840 Val Pro Gln Gln Ser His Gln Gln Ile Leu Pro Gln Gln Gln Gln Asn 1845 1850 1855 Gln Leu Ser Ile Ala Gln Ser His Ser Ala Leu Leu Gln Pro Ser Gln 1860 1865 1870 His Pro Glu Lys Lys Asn Lys Leu Val Ile Lys Glu Lys Glu Lys Glu 1875 1880 1885 Ser Gln Arg Glu Arg Asp Ser Ala Glu Gly Gly Glu Gly Asn Thr Gly 1890 1895 1900 Pro Lys Glu Thr Leu Pro Asp Ala Leu Lys Ala Lys Glu Lys Lys Glu 1905 1910 1915 1920 Leu Ala Pro Gly Gly Gly Ser Glu Pro Ser Met Leu Pro Pro Arg Ile 1925 1930 1935 Ala Ser Asp Ala Arg Gly Asn Ala Thr Lys Ala Leu Leu Glu Asn Phe 1940 1945 1950 Gly Phe Glu Leu Val Ile Gln Tyr Asn Glu Asn Lys Gln Lys Val Gln 1955 1960 1965 Lys Lys Asn Gly Lys Thr Asp Gln Gly Glu Asn Leu Glu Lys Leu Glu 1970 1975 1980 Cys Asp Ser Cys Gly Lys Leu Phe Ser Asn Ile Leu Ile Leu Lys Ser 1985 1990 1995 2000 His Gln Glu His Val His Gln Asn Tyr Phe Pro Phe Lys Gln Leu Glu 2005 2010 2015 Arg Phe Ala Lys Gln Tyr Arg Asp His Tyr Asp Lys Leu Tyr Pro Leu 2020 2025 2030 Arg Pro Gln Thr Pro Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 2035 2040 2045 Pro Pro Leu Pro Ala Ala Pro Pro Gln Pro Ala Ser Thr Pro Ala Ile 2050 2055 2060 Pro Ala Ser Ala Pro Pro Ile Thr Ser Pro Thr Ile Ala Pro Ala Gln 2065 2070 2075 2080 Pro Ser Val Pro Leu Thr Gln Leu Ser Met Pro Met Glu Leu Pro Ile 2085 2090 2095 Phe Ser Pro Leu Met Met Gln Thr Met Pro Leu Gln Thr Leu Pro Ala 2100 2105 2110 Gln Leu Pro Pro Gln Leu Gly Pro Val Glu Pro Leu Pro Ala Asp Leu 2115 2120 2125 Ala Gln Leu Tyr Gln His Gln Leu Asn Pro Thr Leu Leu Gln Gln Gln 2130 2135 2140 Asn Lys Arg Pro Arg Thr Arg Ile Thr Asp Asp Gln Leu Arg Val Leu 2145 2150 2155 2160 Arg Gln Tyr Phe Asp Ile Asn Asn Ser Pro Ser Glu Glu Gln Ile Lys 2165 2170 2175 Glu Met Ala Asp Lys Ser Gly Leu Pro Gln Lys Val Ile Lys His Trp 2180 2185 2190 Phe Arg Asn Thr Leu Phe Lys Glu Arg Gln Arg Asn Lys Asp Ser Pro 2195 2200 2205 Tyr Asn Phe Ser Asn Pro Pro Ile Thr Ser Leu Glu Glu Leu Lys Ile 2210 2215 2220 Asp Ser Arg Pro Pro Ser Pro Glu Pro Pro Lys Gln Glu Tyr Trp Gly 2225 2230 2235 2240 Ser Lys Arg Ser Ser Arg Thr Arg Phe Thr Asp Tyr Gln Leu Arg Val 2245 2250 2255 Leu Gln Asp Phe Phe Asp Ala Asn Ala Tyr Pro Lys Asp Asp Glu Phe 2260 2265 2270 Glu Gln Leu Ser Asn Leu Leu Asn Leu Pro Thr Arg Val Ile Val Val 2275 2280 2285 Trp Phe Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Tyr Glu Asn Gln 2290 2295 2300 Gly Glu Gly Lys Asp Gly Glu Arg Arg Glu Leu Thr Asn Asp Arg Tyr 2305 2310 2315 2320 Ile Arg Thr Ser Asn Leu Asn Tyr Gln Cys Lys Lys Cys Ser Leu Val 2325 2330 2335 Phe Gln Arg Ile Phe Asp Leu Ile Lys His Gln Lys Lys Leu Cys Tyr 2340 2345 2350 Lys Asp Glu Asp Glu Glu Gly Gln Asp Asp Ser Gln Asn Glu Asp Ser 2355 2360 2365 Met Asp Ala Met Glu Ile Leu Thr Pro Thr Ser Ser Ser Cys Ser Thr 2370 2375 2380 Pro Met Pro Ser Gln Ala Tyr Ser Ala Pro Ala Pro Ser Ala Asn Asn 2385 2390 2395 2400 Thr Ala Ser Ser Ala Phe Leu Gln Leu Thr Ala Glu Ala Glu Glu Leu 2405 2410 2415 Ala Thr Phe Asn Ser Lys Thr Glu Ala Gly Asp Glu Lys Pro Lys Leu 2420 2425 2430 Ala Glu Ala Pro Ser Ala Gln Pro Asn Gln Thr Gln Glu Lys Gln Gly 2435 2440 2445 Gln Pro Lys Pro Glu Leu Gln Gln Gln Glu Gln Pro Glu Gln Lys Thr 2450 2455 2460 Asn Thr Pro Gln Gln Lys Leu Pro Gln Leu Val Ser Leu Pro Ser Leu 2465 2470 2475 2480 Pro Gln Pro Pro Pro Gln Ala Pro Pro Pro Gln Cys Pro Leu Pro Gln 2485 2490 2495 Ser Ser Pro Ser Pro Ser Gln Leu Ser His Leu Pro Leu Lys Pro Leu 2500 2505 2510 His Thr Ser Thr Pro Gln Gln Leu Ala Asn Leu Pro Pro Gln Leu Ile 2515 2520 2525 Pro Tyr Gln Cys Asp Gln Cys Lys Leu Ala Phe Pro Ser Phe Glu His 2530 2535 2540 Trp Gln Glu His Gln Gln Leu His Phe Leu Ser Ala Gln Asn Gln Phe 2545 2550 2555 2560 Ile His Pro Gln Phe Leu Asp Arg Ser Leu Asp Met Pro Phe Met Leu 2565 2570 2575 Phe Asp Pro Ser Asn Pro Leu Leu Ala Ser Gln Leu Leu Ser Gly Ala 2580 2585 2590 Ile Pro Gln Ile Pro Ala Ser Ser Ala Thr Ser Pro Ser Thr Pro Thr 2595 2600 2605 Ser Thr Met Asn Thr Leu Lys Arg Lys Leu Glu Glu Lys Ala Ser Ala 2610 2615 2620 Ser Pro Gly Glu Asn Asp Ser Gly Thr Gly Gly Glu Glu Pro Gln Arg 2625 2630 2635 2640 Asp Lys Arg Leu Arg Thr Thr Ile Thr Pro Glu Gln Leu Glu Ile Leu 2645 2650 2655 Tyr Gln Lys Tyr Leu Leu Asp Ser Asn Pro Thr Arg Lys Met Leu Asp 2660 2665 2670 His Ile Ala His Glu Val Gly Leu Lys Lys Arg Val Val Gln Val Trp 2675 2680 2685 Phe Gln Asn Thr Arg Ala Arg Glu Arg Lys Gly Gln Phe Arg Ala Val 2690 2695 2700 Gly Pro Ala Gln Ala His Arg Arg Cys Pro Phe Cys Arg Ala Leu Phe 2705 2710 2715 2720 Lys Ala Lys Thr Ala Leu Glu Ala His Ile Arg Ser Arg His Trp His 2725 2730 2735 Glu Ala Lys Arg Ala Gly Tyr Asn Leu Thr Leu Ser Ala Met Leu Leu 2740 2745 2750 Asp Cys Asp Gly Gly Leu Gln Met Lys Gly Asp Ile Phe Asp Gly Thr 2755 2760 2765 Ser Phe Ser His Leu Pro Pro Ser Ser Ser Asp Gly Gln Gly Val Pro 2770 2775 2780 Leu Ser Pro Val Ser Lys Thr Met Glu Leu Ser Pro Arg Thr Leu Leu 2785 2790 2795 2800 Ser Pro Ser Ser Ile Lys Val Glu Gly Ile Glu Asp Phe Glu Ser Pro 2805 2810 2815 Ser Met Ser Ser Val Asn Leu Asn Phe Asp Gln Thr Lys Leu Asp Asn 2820 2825 2830 Asp Asp Cys Ser Ser Val Asn Thr Ala Ile Thr Asp Thr Thr Thr Gly 2835 2840 2845 Asp Glu Gly Asn Ala Asp Asn Asp Ser Ala Thr Gly Ile Ala Thr Glu 2850 2855 2860 Thr Lys Ser Ser Ser Ala Pro Asn Glu Gly Leu Thr Lys Ala Ala Met 2865 2870 2875 2880 Met Ala Met Ser Glu Tyr Glu Asp Arg Leu Ser Ser Gly Leu Val Ser 2885 2890 2895 Pro Ala Pro Ser Phe Tyr Ser Lys Glu Tyr Asp Asn Glu Gly Thr Val 2900 2905 2910 Asp Tyr Ser Glu Thr Ser Ser Leu Ala Asp Pro Cys Ser Pro Ser Pro 2915 2920 2925 Gly Ala Ser Gly Ser Ala Gly Lys Ser Gly Asp Ser Gly Asp Arg Pro 2930 2935 2940 Gly Gln Lys Arg Phe Arg Thr Gln Met Thr Asn Leu Gln Leu Lys Val 2945 2950 2955 2960 Leu Lys Ser Cys Phe Asn Asp Tyr Arg Thr Pro Thr Met Leu Glu Cys 2965 2970 2975 Glu Val Leu Gly Asn Asp Ile Gly Leu Pro Lys Arg Val Val Gln Val 2980 2985 2990 Trp Phe Gln Asn Ala Arg Ala Lys Glu Lys Lys Ser Lys Leu Ser Met 2995 3000 3005 Ala Lys His Phe Gly Ile Asn Gln Thr Ser Tyr Glu Gly Pro Lys Thr 3010 3015 3020 Glu Cys Thr Leu Cys Gly Ile Lys Tyr Ser Ala Arg Leu Ser Val Arg 3025 3030 3035 3040 Asp His Ile Phe Ser Gln Gln His Ile Ser Lys Val Lys Asp Thr Ile 3045 3050 3055 Gly Ser Gln Leu Asp Lys Glu Lys Glu Tyr Phe Asp Pro Ala Thr Val 3060 3065 3070 Arg Gln Leu Met Ala Gln Gln Glu Leu Asp Arg Ile Lys Lys Ala Asn 3075 3080 3085 Glu Val Leu Gly Leu Ala Ala Gln Gln Gln Gly Met Phe Asp Asn Thr 3090 3095 3100 Pro Leu Gln Ala Leu Asn Leu Pro Thr Ala Tyr Pro Ala Leu Gln Gly 3105 3110 3115 3120 Ile Pro Pro Val Leu Leu Pro Gly Leu Asn Ser Pro Ser Leu Pro Gly 3125 3130 3135 Phe Thr Pro Ser Asn Thr Ala Leu Thr Ser Pro Lys Pro Asn Leu Met 3140 3145 3150 Gly Leu Pro Ser Thr Thr Val Pro Ser Pro Gly Leu Pro Thr Ser Gly 3155 3160 3165 Leu Pro Asn Lys Pro Ser Ser Ala Ser Leu Ser Ser Pro Thr Pro Ala 3170 3175 3180 Gln Ala Thr Met Ala Met Gly Pro Gln Gln Pro Pro Gln Gln Gln Gln 3185 3190 3195 3200 Gln Gln Gln Gln Pro Gln Val Gln Gln Pro Pro Pro Pro Pro Ala Ala 3205 3210 3215 Gln Pro Pro Pro Thr Pro Gln Leu Pro Leu Gln Gln Gln Gln Gln Arg 3220 3225 3230 Lys Asp Lys Asp Ser Glu Lys Val Lys Glu Lys Glu Lys Ala His Lys 3235 3240 3245 Gly Lys Gly Glu Pro Leu Pro Val Pro Lys Lys Glu Lys Gly Glu Ala 3250 3255 3260 Pro Thr Ala Thr Ala Ala Thr Ile Ser Ala Pro Leu Pro Thr Met Glu 3265 3270 3275 3280 Tyr Ala Val Asp Pro Ala Gln Leu Gln Ala Leu Gln Ala Ala Leu Thr 3285 3290 3295 Ser Asp Pro Thr Ala Leu Leu Thr Ser Gln Phe Leu Pro Tyr Phe Val 3300 3305 3310 Pro Gly Phe Ser Pro Tyr Tyr Ala Pro Gln Ile Pro Gly Ala Leu Gln 3315 3320 3325 Ser Gly Tyr Leu Gln Pro Met Tyr Gly Met Glu Gly Leu Phe Pro Tyr 3330 3335 3340 Ser Pro Ala Leu Ser Gln Ala Leu Met Gly Leu Ser Pro Gly Ser Leu 3345 3350 3355 3360 Leu Gln Gln Tyr Gln Gln Tyr Gln Gln Ser Leu Gln Glu Ala Ile Gln 3365 3370 3375 Gln Gln Gln Gln Arg Gln Leu Gln Gln Gln Gln Gln Gln Lys Val Gln 3380 3385 3390 Gln Gln Gln Pro Lys Ala Ser Gln Thr Pro Val Pro Pro Gly Ala Pro 3395 3400 3405 Ser Pro Asp Lys Asp Pro Ala Lys Glu Ser Pro Lys Pro Glu Glu Gln 3410 3415 3420 Lys Asn Thr Pro Arg Glu Val Ser Pro Leu Leu Pro Lys Leu Pro Glu 3425 3430 3435 3440 Glu Pro Glu Ala Glu Ser Lys Ser Ala Asp Ser Leu Tyr Asp Pro Phe 3445 3450 3455 Ile Val Pro Lys Val Gln Tyr Lys Leu Val Cys Arg Lys Cys Gln Ala 3460 3465 3470 Gly Phe Ser Asp Glu Glu Ala Ala Arg Ser His Leu Lys Ser Leu Cys 3475 3480 3485 Phe Phe Gly Gln Ser Val Val Asn Leu Gln Glu Met Val Leu His Val 3490 3495 3500 Pro Thr Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly 3505 3510 3515 3520 Gly Gly Gly Gly Gly Gly Gly Ser Tyr His Cys Leu Ala Cys Glu Ser 3525 3530 3535 Ala Leu Cys Gly Glu Glu Ala Leu Ser Gln His Leu Glu Ser Ala Leu 3540 3545 3550 His Lys His Arg Thr Ile Thr Arg Ala Ala Arg Asn Ala Lys Glu His 3555 3560 3565 Pro Ser Leu Leu Pro His Ser Ala Cys Phe Pro Asp Pro Ser Thr Ala 3570 3575 3580 Ser Thr Ser Gln Ser Ala Ala His Ser Asn Asp Ser Pro Pro Pro Pro 3585 3590 3595 3600 Ser Ala Ala Ala Pro Ser Ser Ala Ser Pro His Ala Ser Arg Lys Ser 3605 3610 3615 Trp Pro Gln Val Val Ser Arg Ala Ser Ala Ala Lys Pro Pro Ser Phe 3620 3625 3630 Pro Pro Leu Ser Ser Ser Ser Thr Val Thr Ser Ser Ser Cys Ser Thr 3635 3640 3645 Ser Gly Val Gln Pro Ser Met Pro Thr Asp Asp Tyr Ser Glu Glu Ser 3650 3655 3660 Asp Thr Asp Leu Ser Gln Lys Ser Asp Gly Pro Ala Ser Pro Val Glu 3665 3670 3675 3680 Gly Pro Lys Asp Pro Ser Cys Pro Lys Asp Ser Gly Leu Thr Ser Val 3685 3690 3695 Gly Thr Asp Thr Phe Arg Leu 3700 <210> 308 <211> 210 <212> PRT <213> Homo sapiens <400> 308 Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 1 5 10 15 Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 20 25 30 Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 35 40 45 Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 50 55 60 Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 65 70 75 80 Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 85 90 95 Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 100 105 110 Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 115 120 125 Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 130 135 140 Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 145 150 155 160 Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 165 170 175 Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 180 185 190 Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 195 200 205 Lys Gln 210 <210> 309 <211> 340 <212> PRT <213> Homo sapiens <400> 309 Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 1 5 10 15 Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 20 25 30 Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 35 40 45 Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 50 55 60 Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 65 70 75 80 Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 85 90 95 Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 100 105 110 Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 115 120 125 Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 130 135 140 Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 145 150 155 160 Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 165 170 175 Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 180 185 190 Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 195 200 205 Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 210 215 220 Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 225 230 235 240 Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 245 250 255 Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 260 265 270 Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 275 280 285 Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 290 295 300 Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 305 310 315 320 Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 325 330 335 Gly Thr Cys Tyr 340 <210> 310 <211> 152 <212> PRT <213> Homo sapiens <400> 310 Met Ala Asp Ser Glu Arg Leu Ser Ala Pro Gly Cys Trp Ala Ala Cys 1 5 10 15 Thr Asn Phe Ser Arg Thr Arg Lys Gly Ile Leu Leu Phe Ala Glu Ile 20 25 30 Ile Leu Cys Leu Val Ile Leu Ile Cys Phe Ser Ala Ser Thr Pro Gly 35 40 45 Tyr Ser Ser Leu Ser Val Ile Glu Met Ile Leu Ala Ala Ile Phe Phe 50 55 60 Val Val Tyr Met Cys Asp Leu His Thr Lys Ile Pro Phe Ile Asn Trp 65 70 75 80 Pro Trp Ser Asp Phe Phe Arg Thr Leu Ile Ala Ala Ile Leu Tyr Leu 85 90 95 Ile Thr Ser Ile Val Val Leu Val Glu Arg Gly Asn His Ser Lys Ile 100 105 110 Val Ala Gly Val Leu Gly Leu Ile Ala Thr Cys Leu Phe Gly Tyr Asp 115 120 125 Ala Tyr Val Thr Phe Pro Val Arg Gln Pro Arg His Thr Ala Ala Pro 130 135 140 Thr Asp Pro Ala Asp Gly Pro Val 145 150 <210> 311 <211> 492 <212> PRT <213> Homo sapiens <400> 311 Met Ser Thr Thr Leu Leu Ser Ala Phe Tyr Asp Val Asp Phe Leu Cys 1 5 10 15 Lys Thr Glu Lys Ser Leu Ala Asn Leu Asn Leu Asn Asn Met Leu Asp 20 25 30 Lys Lys Ala Val Gly Thr Pro Val Ala Ala Ala Pro Ser Ser Gly Phe 35 40 45 Ala Pro Gly Phe Leu Arg Arg His Ser Ala Ser Asn Leu His Ala Leu 50 55 60 Ala His Pro Ala Pro Ser Pro Gly Ser Cys Ser Pro Lys Phe Pro Gly 65 70 75 80 Ala Ala Asn Gly Ser Ser Cys Gly Ser Ala Ala Ala Gly Gly Pro Thr 85 90 95 Ser Tyr Gly Thr Leu Lys Glu Pro Ser Gly Gly Gly Gly Thr Ala Leu 100 105 110 Leu Asn Lys Glu Asn Lys Phe Arg Asp Arg Ser Phe Ser Glu Asn Gly 115 120 125 Asp Arg Ser Gln His Leu Leu His Leu Gln Gln Gln Gln Lys Gly Gly 130 135 140 Gly Gly Ser Gln Ile Asn Ser Thr Arg Tyr Lys Thr Glu Leu Cys Arg 145 150 155 160 Pro Phe Glu Glu Ser Gly Thr Cys Lys Tyr Gly Glu Lys Cys Gln Phe 165 170 175 Ala His Gly Phe His Glu Leu Arg Ser Leu Thr Arg His Pro Lys Tyr 180 185 190 Lys Thr Glu Leu Cys Arg Thr Phe His Thr Ile Gly Phe Cys Pro Tyr 195 200 205 Gly Pro Arg Cys His Phe Ile His Asn Ala Asp Glu Arg Arg Pro Ala 210 215 220 Pro Ser Gly Gly Ala Ser Gly Asp Leu Arg Ala Phe Gly Thr Arg Asp 225 230 235 240 Ala Leu His Leu Gly Phe Pro Arg Glu Pro Arg Pro Lys Leu His His 245 250 255 Ser Leu Ser Phe Ser Gly Phe Pro Ser Gly His His Gln Pro Pro Gly 260 265 270 Gly Leu Glu Ser Pro Leu Leu Leu Asp Ser Pro Thr Ser Arg Thr Pro 275 280 285 Pro Pro Pro Ser Cys Ser Ser Ala Ser Ser Cys Ser Ser Ser Ala Ser 290 295 300 Ser Cys Ser Ser Ala Ser Ala Ala Ser Thr Pro Ser Gly Thr Pro Thr 305 310 315 320 Cys Cys Ala Ser Ala Ala Ala Ala Leu Arg Leu Leu Tyr Gly Thr Gly 325 330 335 Gly Ala Glu Asp Leu Leu Ala Pro Gly Ala Pro Cys Ala Ala Cys Ser 340 345 350 Ser Ala Ser Cys Ala Asn Asn Ala Phe Ala Phe Gly Pro Glu Leu Ser 355 360 365 Ser Leu Ile Thr Pro Leu Ala Ile Gln Thr His Asn Phe Ala Ala Val 370 375 380 Ala Ala Ala Ala Tyr Tyr Arg Ser Gln Gln Gln Gln Gln Gln Gln Gly 385 390 395 400 Leu Ala Pro Pro Ala Gln Pro Pro Ala Pro Pro Ser Ala Thr Leu Pro 405 410 415 Ala Gly Ala Ala Ala Pro Pro Ser Pro Pro Phe Ser Phe Gln Leu Pro 420 425 430 Arg Arg Leu Ser Asp Ser Pro Val Phe Asp Ala Pro Pro Ser Pro Pro 435 440 445 Asp Ser Leu Ser Asp Arg Asp Ser Tyr Leu Ser Gly Ser Leu Ser Ser 450 455 460 Gly Ser Leu Ser Gly Ser Glu Ser Pro Ser Leu Asp Pro Gly Arg Arg 465 470 475 480 Leu Pro Ile Phe Ser Arg Leu Ser Ile Ser Asp Asp 485 490 <210> 312 <211> 256 <212> PRT <213> Homo sapiens <400> 312 Ser Met Lys Ala Leu Leu Ala Leu Pro Leu Leu Leu Leu Leu Ser Thr 1 5 10 15 Pro Pro Cys Ala Pro Gln Val Ser Gly Ile Arg Gly Asp Ala Leu Glu 20 25 30 Arg Phe Cys Leu Gln Gln Pro Leu Asp Cys Asp Asp Ile Tyr Ala Gln 35 40 45 Gly Tyr Gln Ser Asp Gly Val Tyr Leu Ile Tyr Pro Ser Gly Pro Ser 50 55 60 Val Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp 65 70 75 80 Thr Val Phe Gln Lys Arg Phe Asn Gly Ser Val Ser Phe Phe Arg Gly 85 90 95 Trp Asn Asp Tyr Lys Leu Gly Phe Gly Arg Ala Asp Gly Glu Tyr Trp 100 105 110 Leu Gly Leu Gln Asn Met His Leu Leu Thr Leu Lys Gln Lys Tyr Glu 115 120 125 Leu Arg Val Asp Leu Glu Asp Phe Glu Asn Asn Thr Ala Tyr Ala Lys 130 135 140 Tyr Ala Asp Phe Ser Ile Ser Pro Asn Ala Val Ser Ala Glu Glu Asp 145 150 155 160 Gly Tyr Thr Leu Phe Val Ala Gly Phe Glu Asp Gly Gly Ala Gly Asp 165 170 175 Ser Leu Ser Tyr His Ser Gly Gln Lys Phe Ser Thr Phe Asp Arg Asp 180 185 190 Gln Asp Leu Phe Val Gln Asn Cys Ala Ala Leu Ser Ser Gly Ala Phe 195 200 205 Trp Phe Arg Ser Cys His Phe Ala Asn Leu Asn Gly Phe Tyr Leu Gly 210 215 220 Gly Ser His Leu Ser Tyr Ala Asn Gly Ile Asn Trp Ala Gln Trp Lys 225 230 235 240 Gly Phe Tyr Tyr Ser Leu Lys Arg Thr Glu Met Lys Ile Arg Arg Ala 245 250 255 <210> 313 <211> 915 <212> PRT <213> Homo sapiens <400> 313 Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 1 5 10 15 Thr Phe Ala Val Gly Val Ser Ile Cys Leu Gly Phe Thr Ala His Arg 20 25 30 Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 35 40 45 Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 50 55 60 Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 65 70 75 80 Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 85 90 95 Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 100 105 110 Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 115 120 125 Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 130 135 140 Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 145 150 155 160 Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 165 170 175 Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 180 185 190 Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 195 200 205 Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 210 215 220 Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 225 230 235 240 Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 245 250 255 Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 260 265 270 Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 275 280 285 Ile Leu Arg Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 290 295 300 Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 305 310 315 320 Phe Gly Pro Glu Glu Ser Ser Tyr Gly Ser Pro Phe Thr Pro Ala Lys 325 330 335 Arg Pro Lys Arg Lys Val Ala Pro Lys Arg Arg Gln Glu Arg Pro Val 340 345 350 Ala Pro Pro Lys Lys Arg Arg Arg Lys Ile His Arg Met Asp His Tyr 355 360 365 Ala Ala Glu Thr Arg Gln Asp Lys Met Thr Asn Pro Leu Arg Glu Ile 370 375 380 Asp Lys Ile Val Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu 385 390 395 400 Arg Arg Cys Val Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp 405 410 415 Val Thr Cys Asp Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val 420 425 430 Asp Asp Ile Thr Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys 435 440 445 Phe Ser Asn Asn Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu 450 455 460 Thr Cys Lys Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His 465 470 475 480 Leu Pro Lys Arg Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile 485 490 495 His Leu Leu Val Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp 500 505 510 Val Tyr Lys Lys Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly 515 520 525 Phe Asp Asn Lys Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly 530 535 540 Pro Thr Phe Lys Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu 545 550 555 560 Leu Tyr Asn Val Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn 565 570 575 Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe 580 585 590 Arg Pro Thr Met Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile 595 600 605 Met Tyr Leu Gln Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys 610 615 620 Val Glu Pro Lys Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr 625 630 635 640 Lys Gly Ser Thr Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val 645 650 655 Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser 660 665 670 Gly Tyr Ser Glu Ile Phe Leu Met Leu Leu Trp Thr Ser Tyr Thr Val 675 680 685 Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys 690 695 700 Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu 705 710 715 720 Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro 725 730 735 Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr 740 745 750 Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe 755 760 765 Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn 770 775 780 Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp 785 790 795 800 Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val 805 810 815 Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln 820 825 830 Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu 835 840 845 Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu 850 855 860 Ser Lys Trp Val Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg 865 870 875 880 Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg 885 890 895 Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu 900 905 910 Ser Glu Ile 915 <210> 314 <211> 726 <212> DNA <213> Homo sapiens <400> 314 tttttttttt tatggattat ttcatttcat tacactcaaa catccggctg aggcatatac 60 tttaatctct ttaataacag atgggaataa taactcaatg gcataaagag tttaagacac 120 ttgccaagga ttccacaact agaagtgaca gaggcaggat ttgaacccag agcccactct 180 gtcaatcact ttgtaagtta caaagattag gccttcccta aatagcagtc atgtgaattg 240 gtttctaggc ataggatttc ttttgcaata tcaaactctt ttattattga aagtgctctt 300 ctataattga aaattaaaat tgcatgccaa tttttttcaa atttttccta gaactcaaaa 360 ttttattata aagtaatcta ctttttcagg gtaaaaatgt ctgtttatag ttttataact 420 tctctaatga taacttaccc taaattaatt ttaaaattct tacatctttc aaaagtagtt 480 accattcaga tcacctgttt tccaattatg atgttaacat agtataagaa ttcatacccg 540 ggtaactgtt tcaaaactag agacttcaat atggttcacc acttaccagc ttttaaccaa 600 ttgcactgaa gaggtattta ctaattgggt cgggaggata tcaatttcct tcagaatgtt 660 ggcgagtctc acaggcaatt cttgtcgcaa aaatgcaaaa gaagttcttt cacatgcatt 720 gtctga 726 <210> 315 <211> 502 <212> DNA <213> Homo sapiens <400> 315 tttttttttt ttttttttga gataggctct ctcactctgt tgcccaaact gaagtacagt 60 gacacaatca tagctcactg cagcctcaac ctgctgggcc caagtgatcc tcccacctca 120 gcttcctgag tagctgggac tacaagtgta caccaccaca cccagctaat ttttaaaaat 180 ttttggtaga cactgggtct cactatgttg cccaggctgg ccttaaactc ctgggctcaa 240 gtgatcctcc cacctcagct tccctaagtt gctgggatta taggagtgag tcactgcgcc 300 gggcctactt ttttgttttc tctaagtagg acaaaagatc acttacattt tgtttcaact 360 gtgatatacc tcagagcttt tctttttgta agtcatggtt ctacttctct gtggtaaata 420 aagtgtanaa gcctcacggg actgagactt tgggcacctg tggatggcag tggagggaac 480 acgggctttg ctccgaccag tt 502 <210> 316 <211> 374 <212> DNA <213> Homo sapiens <400> 316 cacagcctat ngagcagccc tgatctgcaa ggatcggcat ctctggcgct gctgtgcaca 60 gctgcttcca tgaaagcttc tgcctaacac caccagctca cccttnantc tttgggcaaa 120 tccaagaact ctcccaggct aagccccagt cttggnttgt nctgtncctg catcatctgg 180 caaccagcaa agggacaagg acagcggaga tggtggcaat tggcagagag gcaagacagc 240 agagacagag aggcagcaat tngtgagaga caagagacag cagttggcaa gtncagcang 300 agacggtgaa gcagtntgtg attaaggatg tngttgaaac tctagtggac agccaagtgt 360 ccatagtaca gctg 374 <210> 317 <211> 477 <212> DNA <213> Homo sapiens <400> 317 aggagttttt tttttaattg gacagttgcc catattaacg gaaatcaaaa gcagcataca 60 gtcattcaat gtcccagcac tggagtacag cccactgttt tccngtgtgg ggttccactt 120 tagttcttgt ctgtgtgcat gcatacattt ttacagagtt gtgaccacgc ctttttctgt 180 gaccctggnt attgacatct agttttccaa gtaacattga cacacatctg ttcaaatcag 240 ttgaggttcc catcatgact gactcatttg ggcggggaaa accaaattta catgccaatt 300 gggaacaaag gaaggtntgg ggtatggggg ggaacagcgg gggggggaaa ggaaatgggt 360 gggggagaag ggattccnct gggnctttac caggttccat naaaacattt tccccaataa 420 cattttttaa agggntgtat aatattacac cgaggggatt ggnttattat atttacc 477 <210> 318 <211> 526 <212> DNA <213> Homo sapiens <400> 318 acgaagcaat gactttctca gggagaaaga tttgcatcca tgctgaggaa acagacaggg 60 ccagtaatca cacagcaaca atcatctgta acttgcagaa attcaatgta tgaataagtg 120 tttaaagcct agatagaggg caattatctg gttatctgtt tttcatattt ctatcagaga 180 taaaaacctc tttagggaaa tttatgaagg gccatttgaa agaaggtttc cctcttttgt 240 agaaaagaat tctcttaaaa attaaaacaa atttgggagg ctgggggatt tttgagagtt 300 taaaagagtg aggaagatgg ggggcgggaa gcaactattt ccagctgcga gaaaccgatc 360 aacctcacag caaggtgtgg tggctctgat gcaagcaaca ttcccataga tacagggctg 420 tctggttttc tattgctcat tctaacttga ggagacgctc aagtgtgatt tggggctttg 480 acactgaaaa taggtgtgaa cttggatcca tttaacctag cccctt 526 <210> 319 <211> 533 <212> DNA <213> Homo sapiens <400> 319 actgtctatc tgtctgtata ggtatttcta gttttcaggg tctcctcttt caaggaattt 60 acaatctggc ttgggaaagc aaaatgaaga cacatgaaat aatgagaaag ccatgccata 120 aagccatccc tgttattcca agcaaagtca tgggtttgaa gagaagaaag agaggtcttc 180 atgcactgaa gttggtgata gcatttgtac attaaaaata taaattgaag tcaacaatta 240 gtgcagagaa gtgagactca gcaaatgggc agatgtaatt gtgaaaattc tgtaaacagg 300 cttgggtaac agtcccatag agaggacttg taggcatcca gtgagaatgt ggtttttgta 360 ggacaaaggt ctcactggat ctcagtacca agcctttgcc atgatcagct ggaatgaagg 420 cgctgggaca ctgaagcttg gttggcattc cgggaggaaa aatattcagt atctttccat 480 atcattcatt aaggtctgtg tgacaatgtc atgagcaatt cactactggg agg 533 <210> 320 <211> 624 <212> DNA <213> Homo sapiens <400> 320 ttttttttct tttctataaa acttcatttt gtaatttttt tccaagaagt agtaaggggg 60 aaatattgca attatgtaaa ggtaaggaac aatggtgtat aaaaataatt taagcacaat 120 attaataaca aagcaacttt ttttcaagga aaactagtag gtcatcttgc ccaagatttt 180 tccaaaggta ttaaatatat tttcaataac agtacataca aatacacata cacaaatata 240 ccacacagac acatgtgcac atacatgcac acacacacac acacacacac acacacacac 300 acacacatat atatatatac agctcaagta tttttttggt gtgcattcta gctaatccac 360 atagctaaag tgaaaaaaca ctgaaaagat caatgcctga gtaaccttaa atttgaacaa 420 actatgcatt ggatgtgaat ttttggaggc atgctaagat ttcccttctc aatttcatta 480 gctactaccc agtgttctgt ggttcttatc cttaaaaaaa tcaaagtgtg cctttcagat 540 ctgctcacgg tgtggtgatg attattatgg tggcgtcaat ttgggaacac ttgccctctc 600 ttgctcctac tgcaccttat ggat 624 <210> 321 <211> 534 <212> DNA <213> Homo sapiens <400> 321 tttgaaagca ttatttatat tttaataata aagtacatac catggacata aaatgaaaat 60 gcatataaat tgaatagatt attatttagg tacatcagtt aagtagcatt tagttgttta 120 ataaataaca gactaaatct gaaataattc ttagtttggt aagttctaag tataattatt 180 taagaaataa gagaatatat acaataatat atccattctt gtcgttcatt caaaggcatt 240 acatgttgac aaaccattgt agatttgggt cccacttcta ctgcaaatat gttgagtcct 300 ctgttgttta tgcagttttt acttagctca ttgctgatgt gaataatcac tttctcatct 360 gacttgtttt caataactga cgttatccag gtgtcacaac tgtaagtatg cacgattata 420 ttttcatagc catccattac tttggcatca ccgttgctaa gaacagattt acaaatggcc 480 ttctcaagtt gtccactaca tgcctccata tggacagctn taattnttgg cttg 534 <210> 322 <211> 424 <212> DNA <213> Homo sapiens <400> 322 tcgacgtgga aacaaacaac aaaactgtac atttttttta aagtttgttg aaaagaatat 60 tgtcttattc tataaaacat ttcaaaccta gttagagatt tgtaatcaaa aaacatttgc 120 gcagaaagca gcacttaggg ctncntgttc tataccctac agtcagacag gaaaagaact 180 gaaaatggca cccttctgac attctgaggc agctggactg gcagccaagt aaaggagagt 240 gatgaggtgg tgtggggagg gtggggaggc agcgcgaggg tgctctccac agcaggtagg 300 agcaggcagg agtggggacg gagggagagc ttgtgactgg gacagtgaaa ataaacgatt 360 ggctcttatc aatcacttgc accaactaaa aaggnggaaa aaaaaaaagt cgacgcggcc 420 ggaa 424 <210> 323 <211> 554 <212> DNA <213> Homo sapiens <400> 323 tttacacagc cacagtatgt tcttgttttc attcctgcca gtcagcctgt ttatgatgct 60 gtcaaaccac cttctgatac tgtacatcgc aaggatatac catctcatgt gtatgacatt 120 cgccatttct cccctaccag atcgattaag acaaaggaaa acacatattc ctggggagga 180 aagggaatag tcctggcttt agaaaacaga ctaagccaga agaaacactt gcagtaacag 240 ctacaaggct agactaatgg ggtttgggag gcaggggcaa caggctgagg gcagggcaga 300 aaagtcatgg ccccttccct gccttgacag tggccagact gtccacttgg cacttcttat 360 tagctggcag caagaggtca ggtggtaatg gccaaagctc tgcagggaag gagaactggc 420 ttgatcttca ggactcttga agggatgtga tggtcactgg tccctactaa gggctgaacg 480 atgtcaacaa ctccttcctg aaaggcaggt ggcccggtac cagctgaagt gccgtcaaaa 540 tgcttcatac agac 554 <210> 324 <211> 722 <212> DNA <213> Homo sapiens <400> 324 attttaattt caatatttta aaatacagaa attggaaaga atactaaata caactttaaa 60 caagtcactt gtcctcccct ataataatca atgtaagcta cttaaagact tacaaattta 120 aagtaaaaca gaaacaaaat aaatactgta cactttccct gcctgcaggc aaaagatggg 180 aaatactgtt atgaatcagc aaagaaatgc tcttcaagct tcagcacccc acctcccagc 240 cacaccccac gccattgtca cacagtgggc ttccggactg aaaggacaca catgtcacac 300 acattgactg cctatacaaa caagacgaga cgctattccg cagacacccc caacaagaag 360 aacagtcccc tcggaccgtg ggcataaaaa ccagtaagaa aagtcagtca ggctagcaaa 420 acgttactac aaaactagta aataccagag ccaacaactg tcccctctcc aaagttcaca 480 gatttgaaac ctctaaaacc aatactaccc ctccccatca ccccccaaaa aaacttgctg 540 aagcactggc aaagttagac atttcacagt aaatgggaaa gttcatatta tataatctct 600 taaaatgaac cttttcaccc tctttccaca gcatgaaact gttatggctt aatttatatt 660 taaaagtaga aaagtctttt ctgaagggaa ataccatctg cgaagatgca tttcctgatc 720 ag 722 <210> 325 <211> 566 <212> DNA <213> Homo sapiens <400> 325 tttgtcttcc tattcacatt acaaaaggaa agggcaaggt tctgcagaac tgacgaagga 60 actaacagat actacaaaaa tattacaatt tgtgaagatt agctcaaccc tctcagcttt 120 tatgaatgga gcggggaggg gcccaggctg agtgggaagg gcatgggagt gagggggcca 180 gctagttcta tggaatagtt tgattttttt ctcttccttc cccaccaatg gtgaatgaca 240 tctttgctgt taaaaatact gttttctggg atttacagat cccctgaggg ccagccagtc 300 cccgcttctt cccagaccag aggaggaagc catagtgcat aatgatttct tacagacggc 360 ccctccccca aatgatttca cccttttcac attataaaca tgacaactgt tctagtcacg 420 tatttcaagt ttaacttctt ttcctttcca aaacactaag tcgttactat agttgcaaaa 480 tagcatcctc cctactttac catccctaat ccacagtcta gtgacaccgt cctcccaatt 540 cacatcctcc caacacacaa ttntaa 566 <210> 326 <211> 559 <212> DNA <213> Homo sapiens <400> 326 tttttttttt tccacctctt aagtatttat tagataccca ttgtgtaccc tctccccgct 60 ttgtatccct gccctgaggg ctncacagcc agatctcctg agagcagagt gaagaggaag 120 ctcagtattt ctcaggcagg ccagcaggtc ggaagtgatt ggggtctttg ccactcctgc 180 cccattcatt ggcagcctga tcggccagcg agtcctccgc accatggcca aagaatctct 240 ggatattctc tctggcatcg ctgatcgctt ctgcagccca gacaccccca ggtccccttt 300 tggcagcatc atagttcccc cgagcatgga agtatttgtc tgagccgatg taattggctt 360 ctctcatgtc agagtaggct ctccacatgt cccgagcccc atcaaaagcc tcgccaagga 420 acgaaaagaa gcttcggctg ctgacaccca ggaccaagga gcagaaaacc aggcccgtga 480 gaagcttcat ggtgctctct agatcagagg agataagaca ccttcagaat ggtatggctg 540 tatgcccagg ataactatt 559 <210> 327 <211> 704 <212> DNA <213> Homo sapiens <400> 327 tcacatacac ataattttat tatagtatat tgttataact gttctgtttt attattaatt 60 atggtgccta atttaaaaat taaactttat tgtaggtatt tatgtttaga aaaaaaacat 120 agtatgtata agattcggta ctatctgtgg tttcagtcac ccaccggggg tcttagaatg 180 tacccctgtg gataaggggg aactactgta tatactcctc tcttgcaacg cactaagaca 240 gagcgggttt aaaatgtgac cacttgggcc agcttgctgt ggacaatttc actacattta 300 aaactacctt aggtttctga gatacaccta cttaactgta gctatggtaa agaaggattt 360 aatattcagt aatggtacat acttgttatc tcctacctag ggaaatccat agatatccct 420 ttttaccttg aattattatg aaatatgtta ttattcatat cagaacaaag aaataatgca 480 aatttcccat ttccttcact cagttatgac taagaataca tcataagcac agtgaataca 540 tcattacatc accttctaaa tctaaaaaaa gtttatttaa ccaacgtaac catattgaat 600 aaaatcagct tgggagaaaa attagtgctt gctaaatcat ggagaacaac aatatctttt 660 taaacaatat atcccacaga tgttgtaaat tgaatgcgaa cttc 704 <210> 328 <211> 4892 <212> DNA <213> Homo sapiens <400> 328 ctgcagaaat gcctcctcag ctgcaaaacg gcctgaacct ctcggccaaa gttgtccagg 60 gaagcctgga cagcctgccc caggcagtga gggagtttct cgagaataac gctgagctgt 120 gtcagcctga tcacatccac atctgtgacg gctctgagga ggagaatggg cggcttctgg 180 gccagatgga ggaagagggc atcctcaggc ggctgaagaa gtatgacaac tggtaagctc 240 ggcccccgct gcctgtccca gcaccctgca ggcagggctc ccctgcgtct cctgggagtt 300 ggtggagaaa ggtgaatgaa ggccttcggg tagtttcaga ctcttgagaa gatgaatgca 360 atggtcagaa ccatacagac ttgaattttg tgacattagt gggccagccc aagctttaaa 420 tgaggtgtgt gcacaaaagc tctgccaact agattcctga ttaaaaaaaa ggcagcccct 480 ctcctacaga ccagctccta gtggagtaaa tgtccacctg gccatgtctt agacggtctg 540 tgtgttcaca gtgatggact gttgttagcg tgctcagcac tctgctaggc atggaaagcc 600 acggtactga aggagatggt tcgctgcccg tggtgcttgg ctgaaaggaa gcctgtgatt 660 tttgcagctg gttggctctc actgacccca gggatgtggc caggatcgaa agcaagacgg 720 ttatcgtcac ccaagagcaa agagacacag tgcccatccc caaaacaggc ctcagccagc 780 tcggtcgctg gatgtcagag gaggattttg agaaagcgtt caatgccagg ttcccagggt 840 gcatgaaagg tgagcggaac attgatttga ttgggtaaaa cagcagagag ccttttctta 900 tttacatcta tcctaatggt aattcaaaca ataatggaag ctccaccacc tcagatgtct 960 ttcagttcca tacatgaagt tggcaatgta ttgaaaatgc acatccctct tctgctttta 1020 cagactgtct tatacaaacg tgaaaactag ttccatgcat atgggtttta aatagcttgg 1080 tggacccaat tgcacattta tgaaaactct ttaatttcag caggctgttc actttccagt 1140 ggcctcttct aacccagggc ctggtgacca gcagggtgtg gtggtgttag tggaacaccg 1200 tgaaaatggg tctacctggg aaaaaaatgc tggtcgtgtt cgaagtccaa ggtcatttct 1260 caccagtgcc cacccatcgc accctgtagg tcgcaccatg tacgtcatcc cattcagcat 1320 ggggccgctg ggctcacctc tgtcgaagat cggcatcgag ctgacggatt cgccctacgt 1380 ggtggccagc atgcggatca tgacgcggat gggcacgccc gtcctggaag cactgggcga 1440 tggggagttt gtcaaatgcc tccattctgt ggggtgccct ctgcctttac aaagtaagtg 1500 tattatttca gaatcaaaag tcaaaataaa aaagaaagct gaacgcaaac cccagtgagt 1560 gcctcgggga cccccaacca gggccctggc gcactgactt gggaggggtc cttgttcaca 1620 gagcctttgg tcaacaactg gccctgcaac ccggagctga cgctcatcgc ccacctgcct 1680 gaccgcagag agatcatctc ctttggcagt gggtacggcg ggaactcgct gctcgggaag 1740 aagtgctttg ctctcaggaa tgccagccgg ctggccaagg aggaagggtg gctggcagag 1800 cacatgctgg tgagctgcag gaagccctga tgtgcagatg agaggcctgg ggggtggcag 1860 aaacaaacag cattacagtt cccacccgtc agcacacctc tctgagcgtg caggttcccg 1920 gacagatcgg gaaaccccac cagtaatgat tagtttacac atatacatcg cttttgaagg 1980 gcccccaaaa caccagggga ccatagagat ccttttggac ttcatgattc ttgggagtgt 2040 tgttgcactg atacctgaag gaatagatct tgagggccta cattccaacc tctgggctga 2100 agtaccaacc tcggggagaa ggaaacaaag atcacaataa agaatcttgt ccccaacaga 2160 ttctgggtat aaccaaccct gagggtgaga agaagtacct ggcggccgca tttcccagcg 2220 cctgcgggaa gtccaacctg gccatgatga accccagcct ccccgggtgg aaggttgagt 2280 gcgtcgggga tgacattgcc tggatgaagt ttgacgcaca aggtgactct tttagaccca 2340 actcttggta acgattggac tcaagcgaat cgttggcctt cgaaacatgt cacattctcc 2400 tcagtccagt gtttggattt ttaaactctg ttagtccaga gttggccaag ccttagaata 2460 tggatcctgt aagaattctt caacttaata ttcaatctgg attgaaactg ggccatatgt 2520 tgctgtttgt ttacatacat acatttgttt aaatggtatt ggtggaaaat tgtggaggaa 2580 gcaagagtcg taaacgtatc aaagttgcat atgatgcttg gatgaaaaga gataaatgca 2640 tattctaggg agggaaaaaa gatttgagaa gttggcatag aaattagtcc ggcaatatat 2700 aagagtatat gttctgcttt gcctggcact cactactgct tctctggttt aaaactctcc 2760 aggtcattta agggccatca acccagaaaa tggctttttc ggtgtcgctc ctgggacttc 2820 agtgaagacc aaccccaatg ccatcaagac catccagaag aacacaatct ttaccaatgt 2880 ggccgagacc agcgacgggg gcgtttactg ggaaggcatt gatgagccgc tagcttcagg 2940 cgtcaccatc acgtcctgga agaataagga gtggagctca gaggatggtg tgtccctgcc 3000 agaggcctgt gtgtgccggg ctgcagggac tgcctgtttt gagccaggca ctcacgagcc 3060 tttctctgtc ttatagggga accttgtgcc caccccaact cgaggttctg cacccctgcc 3120 agccagtgcc ccatcattga tgctgcctgg gagtctccgg aaggtgttcc cattgaaggc 3180 attatctttg gaggccgtag acctgctggt gaggctctcc ttcatttagg ctgggaacat 3240 gggtgtgctg ggtaccgaag gcatctgtga aatctctcct tttccatgac cttgtcagag 3300 ggtgcccagg ggcttccttt cttgagcttc cttcccaaag atccagaata attggcaagt 3360 tcaaatgtag aaccaaccct tctggtcacc tggaaccttt ctgaatcctt gatctattgt 3420 agcttgatca aattttactt tttactttgt ggcctcagtc atgtaacttt gagttagcag 3480 ttttctgcaa tttagcttgg tgaatgcaaa actagctcga ttacaagtta ttgtcttgcc 3540 gtgtctttcc gtgttgtgaa taacaccact ggttgtggag tctgaatttc aaagcctctg 3600 atgaacattt ctcttttttt ttcctgctaa aggtgtccct ctagtctatg aagctctcag 3660 ctggcaacat ggagtctttg tgggggcggc catgagatca gaggccacag cggctgcaga 3720 acataaaggt aaatcaaagt cctgatctga aaccacagag aagtgggatt agagcactct 3780 tcgtcactct tatgtctctc tccttttctg tgtctgtgtg tggggagaga gagagagaga 3840 aagagagaga ggagaacaaa gcatgctaat gtcaacaatc aatggcgtca gtcttgccta 3900 ggagagcctc atttactaat gaactccctc tctgtttaac aggcaaaatc atcatgcatg 3960 acccctttgc catgcggccc ttctttggct acaacttcgg caaatacctg gcccactggc 4020 ttagcatggc ccagcaccca gcagccaaac tgcccaagat cttccatgtc aactggttcc 4080 ggaaggacaa ggaaggcaaa ttcctctggc caggctttgg agagaactcc agggtgctgg 4140 agtggatgtt caaccggatc gatggaaaag ccagcaccaa gctcacgccc ataggctaca 4200 tccccaagga ggatgccctg aacctgaaag gcctggggca catcaacatg atggagcttt 4260 tcagcatctc caaggaattc tgggagaagg aggtggaaga catcgagaag tatctggagg 4320 atcaagtcaa tgccgacctc ccctgtgaaa tcgagagaga gatccttgcc ttgaagcaaa 4380 gaataagcca gatgtaatca gggcctgagt gctttacctt taaaatcatt ccctttccca 4440 tccataaggt gcagtaggag caagagaggg caagtgttcc caaattgacg ccaccataat 4500 aatcatcacc acaccgtgag cagatctgaa aggcacactt tgattttttt aaggataaga 4560 accacagaac actgggtagt agctaatgaa attgagaagg aaatcttagc atgcctccaa 4620 aaattcacat ccaatgcata gtttgttcaa atttaaggtt actcaggcat tgatcttttc 4680 agtgtttttt cactttagct atgtggatta gctagaatgc acaccaaaaa aatacttgag 4740 ctgtatatat atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgcatgt atgtgcacat 4800 gtgtctgtgt ggatatttgt gtatgtgtat ttgtatgtac tgttattgaa aatatattta 4860 atacctttgg aaaaatcttg ggcaagatga cc 4892 <210> 329 <211> 650 <212> DNA <213> Homo sapiens <400> 329 tttttttggc aactcagtct ttattgatgg tttcattttt ggggtcacca gtgctaagag 60 gtggaaggtg ggggggcacc tttatgtgtg tcaaggaccc cagagcaccc ccctcacgag 120 agaataaatc caatttagaa cttacaaggt ggtggggatg ggaagaggaa gggacacagt 180 atgtacagat gcttaagggg atgctggagg gccttcagca acagggaatg gaggtgccaa 240 agaggaagtc gggcagagtc agccactgat ctggaccccc tcagcctcgg ccagagggta 300 gatctcaatg gcttccacca ggggtagcgc ctccacagca gtctccatga cggccaggcc 360 aacggagacc tccgcctctg ccagctgctg ccgcacagct gcctgatgct gctgctgatg 420 ggtcttgcgg tgcttccaga ggttggagaa ggagcggtac ctntagccac agtcagggca 480 ggagtagggt cgttcgcctg tgtggatgcg gcgatgttct gccaggcgca tggagatggc 540 aaaggcttgc acacacttca caggcaaagg gcgctcacct gtgttcaggc gcgggtgtct 600 ttcaagtggg tatctgacga acgttttgca cagtctggac atgggtatgg 650 <210> 330 <211> 449 <212> DNA <213> Homo sapiens <400> 330 ggttcaacaa caagaactta cttaaaacaa tgtactgtgg tgatgagtcc caggggtact 60 ggtcagcctg tggagccctg gatgctatcc acacccacct atccctgcag ctaatttagc 120 tgatctctaa tttaactgag ctctaattta gctgatcaga ttttgcttgg gtaaagttcc 180 tttttaatgt tctaaagtgt ttacggttct caaatatcag ttaaaaacta attttaggtg 240 gccataaaca taaaatagaa accctgtaag ttacagaaga ccctaaattg tatcaaaacc 300 ctagagacaa cttttcaatt tgatccaaat ttgaactggc caaccagtct ttaaaacact 360 ggactagaag agataatgnt tganacattt agaanaaaaa agtgctccat tcgcaggagc 420 tttttcctgt cctgtgggnt ttccagttg 449 <210> 331 <211> 1667 <212> DNA <213> Homo sapiens <400> 331 aagcacaggc caccactctg ccctggtcca cacaagctcc ggtagcccat ggagccctgg 60 cctctcctcc tgctctttag cctttgctca gctggcctcg tcctgggctc cgaacatgag 120 acccgtctgg tggcaaagct atttaaagac tacagcagcg tggtgcggcc agtggaagac 180 caccgccagg tcgtggaggt caccgtgggc ctgcagctga tacagctcat caatgtggat 240 gaagtaaatc agatcgtgac aaccaatgtg cgtctgaaac agcaatgggt ggattacaac 300 ctaaaatgga atccagatga ctatggcggt gtgaaaaaaa ttcacattcc ttcagaaaag 360 atctggcgcc cagaccttgt tctctataac aatgcagatg gtgactttgc tattgtcaag 420 ttcaccaaag tgctcctgca gtacactggc cacatcacgt ggacacctcc agccatcttt 480 aaaagctact gtgagatcat cgtcacccac tttccctttg atgaacagaa ctgcagcatg 540 aagctgggca cctggaccta cgacggctct gtcgtggcca tcaacccgga aagcgaccag 600 ccagacctga gcaacttcat ggagagcggg gagtgggtga tcaaggagtc ccggggctgg 660 aagcactccg tgacctattc ctgctgcccc gacaccccct acctggacat cacctaccac 720 ttcgtcatgc agcgcctgcc cctctacttc atcgtcaacg tcatcatccc ctgcctgctc 780 ttctccttct taactggcct ggtattctac ctgcccacag actcagggga gaagatgact 840 ctgagcatct ctgtcttact gtctttgact gtgttccttc tggtcatcgt ggagctgatc 900 ccctccacgt ccagtgctgt gcccttgatt ggaaaataca tgctgttcac catggtgttc 960 gtcattgcct ccatcatcat cactgtcatc gtcatcaaca cacaccaccg ctcacccagc 1020 acccatgtca tgcccaactg ggtgcggaag gtttttatcg acactatccc aaatatcatg 1080 tttttctcca caatgaaaag accatccaga gaaaagcaag acaaaaagat ttttacagaa 1140 gacattgata tctctgacat ttctggaaag ccagggcctc cacccatggg cttccactct 1200 cccctgatca aacaccccga ggtgaaaagt gccatcgagg gcatcaagta catcgcagag 1260 accatgaagt cagaccagga gtctaacaat gcggcggcag agtggaagta cgttgcaatg 1320 gtgatggacc acatactcct cggagtcttc atgcttgttt gcatcatcgg aaccctagcc 1380 gtgtttgcag gtcgactcat tgaattaaat cagcaaggat gagcagaaaa tgagctgagc 1440 ttagctctgc cctggaacct accagagcag agaagggcag gagaggaaga tttgtctact 1500 tgctccactc gcacttatca aacgtgttat attccatact tattattgat gataagattt 1560 acctttatgt aagtttatgg ccttgaagtg ttttcatatt gcttctccct ttagttctgc 1620 tgtctccctg aagagtgaac cctctttagt aaatgaaact aatcact 1667 <210> 332 <211> 443 <212> DNA <213> Homo sapiens <400> 332 aaaaaagatc atgaatgaat gattgcatga ttttatgcca ttgtgcttat actaaaggat 60 atgtagccca tctcttgagc tgttaaactg ttttgactac tttaaatcgt gcagctgtga 120 gcatctctgt aaatttagtg tacacatgta tcccctggag tggcattgct cggcagtgag 180 cacttatggt tttataactc tcttcacaga ctcaaatgac tccagaaagc tacacttcct 240 gttgtgagta tatgatatcc atttccctac atagccacta acatcaggtt tttacaattt 300 tatttatttc ttgctacttt aagaaatttt tgtggtgaaa tacatataat agaagttgac 360 tatctgaatc atttttaagt atacattcag tagtgttaag tatgtcgcca ttgttgtaca 420 accaatctcc agaacttttt cat 443 <210> 333 <211> 952 <212> DNA <213> Homo sapiens <400> 333 tgaactctgg atgctgttag cctgagactc aggaagacaa cttctgcagg gtcactccct 60 ggcttctgga ggaaagagaa ggagggcagt gctccagtgg tacagaagtg agacataatg 120 gaatcaggct tcacctccaa ggacacctat ctaagccatt ttaaccctcg ggattaccta 180 gaaaaatatt acaagtttgg ttctaggcac tctgcagaaa gccagattct taagcacctt 240 ctgaaaaatc ttttcaagat attctgccta gacggtgtga agggagacct gctgattgac 300 atcggctctg gccccactat ctatcagctc ctctctgctt gtgaatcctt taaggagatc 360 gtcgtcactg actactcaga ccagaacctg caggagctgg agaagtggct gaagaaagag 420 ccagaggcct ttgactggtc cccagtggtg acctatgtgt gtgatcttga agggaacaga 480 gtcaagggtc cagagaagga ggagaagttg agacaggcgg tcaagcaggt gctgaagtgt 540 gatgtgactc agagccagcc actgggggcc gtccccttac ccccggctga ctgcgtgctc 600 agcacactgt gtctggatgc cgcctgccca gacctcccca cctactgcag ggcgctcagg 660 aacctcggca gcctactgaa gccagggggc ttcctggtga tcatggatgc gctcaagagc 720 agctactaca tgattggtga gcagaagttc tccagcctcc ccctgggccg ggaggcagta 780 gaggctgctg tgaaagaggc tggctacaca atcgaatggt ttgaggtgat ctcgcaaagt 840 tattcttcca ccatggccaa caacgaagga cttttctccc tggtggcgag gaagctgagc 900 agacccctgt gatgcctgtg acctcaatta aagcaattcc tttgacctgt ca 952 <210> 334 <211> 597 <212> DNA <213> Homo sapiens <400> 334 tgaaattgtg aattctaaaa aagaaatgtt gtaaatacaa ttccattaac tacatagaaa 60 ctattaagaa agagagaatc aaaaatattt ttgtgaggga gtcggtccca ggcagtttga 120 tgctctgtgg aaggaggcgg gaagggaacg ttggccaagt cagttactga gatgaagatc 180 gcccagctgc caggaccacc ccaggacaag ttagagcact gtttagctcc tttgtctgtg 240 tgatagacct aagaactgta ttacgtgttg taccagccta ttaacctctt gtctgtgcac 300 agcttcaaat gttaccgtct agttagattt ttatttaaaa tatgaaaaac tgcttttccc 360 aagatgtttt ttaaaaacaa agctacaatt ttaatattta acatatttaa agtttcaaag 420 cacacctgtt tgggcttggg tgggggtccc gtggggggga cattcttttt cagtcctaat 480 ttttaaatat ttgatcattt tccattggcc aatcatttca gcacctccaa aggtccctag 540 gacactttgc nctcttctcc ccctggcccc caacctgctn ccaaatttgg gggncca 597 <210> 335 <211> 455 <212> DNA <213> Homo sapiens <400> 335 tgggcaatat cagaagtgac catagggcat tttaccactg ccccatgtgc aatgcctcga 60 tggcattcca attcattttc tgtcactgcc atgaagttac actcttcaca gcagtagtac 120 cttttatctt tttcatgggt tttagcatgt tgcacaaatg ttttagggca attggtacca 180 aacacacact gaggacactg taatcgtgca cttcttcctt catcctgaag ttctttcaat 240 tcacgaattt cctccatcaa cttctgtctt ctctcctggt gaataatcat atgttttaga 300 agtgaattgc gatctcgaaa tgtccgtcca cattctctac aagcatatgg ccttgggaca 360 ttaagatggc gaaagtgact attcccatct aaatgataca tcatatgcnc tgtggaggtg 420 cttcttctcc ctaaattcac attgcacttt gtaca 455 <210> 336 <211> 353 <212> DNA <213> Homo sapiens <400> 336 tttttttttc aaagttgagc attaaaatat acttagaact ctatagttgg aaaaaagaaa 60 tggttaaatg tggaagccac ttatttaata tgttctttta agagagaaac aaggttttat 120 aaaaagcatg agaaatatat aaatttaagc aaatcactta tgatctaaag atagcacaag 180 tgaaggcctc acttctagga tgttgcaagc aaggtaccaa tgctgccaga cccaagaaga 240 gttttagcag gaaaggttac acttggtttg atttttaaag ccaaagcaag aattatgagt 300 cttaaaccaa atatactaac ttgggccatg gggcagagta acttggataa aga 353 <210> 337 <211> 680 <212> DNA <213> Homo sapiens <400> 337 ggaagaggaa aaccgaatac cccaaccccc acccatcgcc cacccgagga cgtcccccca 60 gccggagtcg ggcatcaagc gactgtttag cttcttctcc cgagataaga agcgcctggc 120 caacacacag agaaacgtgc acatccagga gtcctttgga cagtgggcaa acacccaccg 180 cgatgacggt tacacagagc aaggacagga agccctgcag catctgtgac cttggcccat 240 ctccaccctc caacctggac tgcccgccac cagcgcctgc aaccgaactg cagcccaggg 300 gtcattgctg cctcaagcct ctcggtgcag atgcacctga aaactgaccc ctcaaacaga 360 ctgtctgatt tgaggatgga cattgaaaaa ctgacgccaa actctaaaga aatgtttatt 420 tatacccagg gctatcactg tttctaatag atgactctga tcccgtagat atatatttaa 480 taatcccaca aacggaggcc agacttctgc gttaacttca gtaacacaag cttctttaag 540 ccaaatacat cacttgccac tatcattgtg tttgacttgc ttgtataaat gctatgtgta 600 gaggtttatt atacaggtga catgttcagc angaagatgg aagggctagt ttcataggtt 660 cattcatgaa ttgtgatggt 680 <210> 338 <211> 423 <212> DNA <213> Homo sapiens <400> 338 atttgtttga caacagctac aattgaaata cagcaattct gaaggtcttt aaatgggttg 60 cactttgccc tgttaactca ctatttcctg attggcaata attttacttg gtaatgctct 120 gtattatggt aaaagctaac aataataatt tatcgagtat attctttgta gcaggcacag 180 ttatgagtgc tatgtgaata catttaatct tcacagcaac tttgaagtag ggtactatta 240 ctgtggcata ttttgaagga tggggaaaac tgagggcaga cagtttgcct ctgggagccc 300 tcactctgga aactctttat ggatatatac ccagaaactg tggacatagg cccggggtgc 360 ccaattctgg gccncttcca cctgcttttg gttaaantaa agtttttttt gggattacac 420 cca 423 <210> 339 <211> 394 <212> DNA <213> Homo sapiens <400> 339 tttttttttt tttttttttg gcaattaaaa aaaaaatcaa ggtctttgca gggctgtggc 60 tggggctagt cctctggggc tggagggaca gttacatggt gagccaggag acgattgtca 120 ctggttatgg tttttaagct gtctgctgtg aagagatcaa tgacaccctt tttgtgatcc 180 tcattgtatt gctcctcaaa tgacctgtgg gagtaggata gggcattgtt ttattctgtt 240 gttatggaaa ccagtgaagc atctgagttt catattcagt tggatggagg tacaggactc 300 aaggaaccaa gcctaggagc agagaagact tgaggatgga agcccctgga aatgtacaga 360 cattgtacag ctggattttg gatttcccta ggcg 394 <210> 340 <211> 2147 <212> DNA <213> Homo sapiens <400> 340 gctgccctcc ccgtcagccg ccctcgccgc cgcggtgcgc tggctgcagg aagccgccgc 60 gccgccgctt ttgttgtcag ggacccagcg aggagcgccg ctcgccggcc gccgccaccc 120 tctctcgctg cagcctgctg tgcgctgcac ggcctggggc ccgggcgccc ccgcgtctgc 180 ccatgagggg gccccgcgac caccgctgct tccagcccgg ggcggcgcgg cgctgaggcg 240 gcggcggcgg cggcctgccc cctctgcggg aagcgggcgg ccccggccgc ctccgcgagg 300 gcaccatgga ggtgaatgca ggaggtgtga ttgcctatat cagttcttcc agctcagcct 360 caagccctgc ctcttgtcac agtgagggtt ctgagaatag tttccagtcc tcctcctctt 420 ctgttccatc ttctccaaat agctctaatt ctgataccaa tggtaatccc aagaatggtg 480 atctcgccaa tattgaaggc atcttgaaga atgatcgaat agattgttct atgaaaacaa 540 gcaaatcgag tgcacctggg atgacaaaaa gtcatagtgg tgtgacaaaa tttagtggca 600 tggttctact gtgtaaagtc tgtggggatg tggcgtcagg attccactat ggagttcatg 660 cttgcgaagg ctgtaagggt ttctttcgga gaagtattca acaaaacatc cagtacaaga 720 agtgcctgaa gaatgaaaac tgttctataa tgagaatgaa taggaacaga tgtcagcaat 780 gtcgcttcaa aaagtgtctg tctgttggaa tgtcaagaga tgctgttcgg tttggtcgta 840 ttcctaagcg tgaaaaacag aggatgctaa ttgaaatgca aagtgcaatg aagaccatga 900 tgaacagcca gttcagtggt cacttgcaaa atgacacatt agtagaacat catgaacaga 960 cagccttgcc agcccaggaa cagctgcgac ccaagcccca actggagcaa gaaaacatca 1020 aaagctcttc tcctccatct tctgattttg caaaggaaga agtgattggc atggtgacca 1080 gagctcacaa ggataccttt atgtataatc aagagcagca agaaaactca gctgagagca 1140 tgcagcccca gagaggagaa cggattccca agaacatgga gcaatataat ttaaatcatg 1200 atcattgcgg caatgggctt agcagccatt ttccctgtag tgagagccag cagcatctca 1260 atggacagtt caaagggagg aatataatgc attacccaaa tggtcatgcc atttgtattg 1320 caaatggaca ttgtatgaac ttctccaatg cttatactca aagagtatgt gatagagttc 1380 cgatagatgg attttctcag aatgagaaca agaatagtta cctgtgcaac actggaggaa 1440 gaatgcatct ggtttgtcca atgagtaagt ctccatatgt ggatcctcat aaatcaggac 1500 atgaaatctg ggaagaattt tcgatgagct tcactccagc agtgaaagaa gtggtggaat 1560 ttgcaaagcg tattcctggg ttcagagatc tctctcagca tgaccaggtc aaccttttaa 1620 aggctgggac ttttgaggtt ttaatggtac ggttcgcatc attatttgat gcaaaggaac 1680 gtactgtcac ctttttaagt ggaaagaaat atagtgtgga tgatttacac tcaatgggag 1740 caggggatct gctaaactct atgtttgaat ttagtgagaa gctaaatgcc ctccaactta 1800 gtgatgaaga gatgagtttg tttacagctg ttgtcctggt atctgcagat cgatctggaa 1860 tagaaaacgt caactctgtg gaggctttgc aggaaactct cattcgtgca ctaaggacct 1920 taataatgaa aaaccatcca aatgaggcct ctatttttac aaaactgctt ctaaagttgc 1980 cagatcttcg atctttaaac aacatgcact ctgaggagct cttggccttt aaagttcacc 2040 cttaaggcct ttgtttattt aaacatgaac tgatggtaac tgtacatttt gtgctaaaat 2100 gcatatttat atgtgcatac catatgtgga gatagaaaag accttta 2147 <210> 341 <211> 2065 <212> DNA <213> Homo sapiens <400> 341 agccacctgc aagcctgccg acgctggatg gtttgacttc atctgcacac tcttctttct 60 gacccgctct tccagtcaaa atactttttg ctttcggtca ccgtttaaca atggactgga 120 aactttatcc tctccttcac agcatagtac tgcttggaga agtttctgaa tcgtattaaa 180 tagcctcaaa ttaacagatt ttattcctta gccacctggc atccttccac agggtacatc 240 tctctgcatt cctgacagat ttctttgtct ctttatcatt atagttttcc atatatttgc 300 attgttgctg aaaatattta cacatttgtt gcagtaatct tataaggaag atttcaaggg 360 tttaaatgtg atatcactac tctggaaata tcacagctcc ccctccagcc tcttatcccc 420 caactccaat tccatgtccc cactcattaa aggatgttgt gttgttgaca ttgtggtgtg 480 accgaatcct gcagtctttt ataaattcta agaactgtgg gatattctta cttcttggaa 540 gtgaatcctc ttcaaaaaga gaagacaata attctcctat atctgtcact ttttaaaaga 600 aagaaggaaa gacgaaagga cgaagggaat tagtcaatta aggagacaat cgcccctgaa 660 ttatcgatta acagtaaccc aactgagagt gaaatataat tttataatat atgtgtgttc 720 aatatttgat agttaatgct atttagatat atcatttaga cacacttttt ctcaaaacta 780 aattgatttc atttattata ggttcagaaa atgcatgtga aagaacttct tttgcatttt 840 tgcgacaaga attgcctgtg agactcgcca acattctgaa ggaaattgat atcctcccga 900 cccaattagt aaatacctct tcagtgcaat tggttaaaag ctggtaagtg gtgaaccata 960 ttgaagtctc tagttttgaa acagttaccc gggtatgaat tcttatacta tgttaacatc 1020 ataattggaa aacaggtgat ctgaatggta actacttttg aaagatgtaa gaattttaaa 1080 attaatttag ggtaagttat cattagagaa gttataaaac tataaacaga catttttacc 1140 ctgaaaaagt agattacttt ataataaaat tttgagttct aggaaaaatt tgaaaaaaat 1200 tggcatgcaa ttttaatttt caattataga agagcacttt caataataaa agagtttgat 1260 attgcaaaag aaatcctatg cctagaaacc aattcacatg actgctattt agggaaggcc 1320 taatctttgt aacttacaaa gtgattgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380 nnnnnnnnnn nttgtggaat ccttggcaag tgtcttaaac tctttatgcc attgagttat 1440 tattcccatc tgttattaaa gagattaaag tatatgcctc agagggatgt ttgagtgtaa 1500 tgaaatgaga taatccataa aaaagaaaaa aaaaacccct taggacagca cttggcacac 1560 agccagcagt cagtaagtgt cagttgttgt catctcattt tataaatgaa gatactgatg 1620 cttagagaag gtaggtaacc caaaacagca aatttttggg tcacagaagc aggatatgca 1680 caggtagcag acatgcatga gacccttatc ttaatccact gactgcacag ccttttgttc 1740 attgattcaa gaaatacatg tattatatac ctataagaca attacaatct aaaacatata 1800 ttcaatctgt agtatttact attgcagtca agacttacac tcttctatga atgaatgtag 1860 tagaaaaaaa ataaaaagct ttaaaaaaag ttgtttctaa gtattattgc tagaagaaat 1920 gaaaatattt gccaaacaaa acagtcagga aactgaatac tgacctgaaa tagttaaaga 1980 nacattttgc gttaaatttt aagtttgaaa gtcaaggatt aaaagttata gcattttaaa 2040 tttatattat tttccaaatg ttctg 2065 <210> 342 <211> 1344 <212> DNA <213> Homo sapiens <400> 342 ggaaggtaga aggtggggtc tgccggacgc gtgttcctgc caccaggtgc ccgctccccg 60 cgaggccggc tcaggagcag aaggaagccc ggtgccagcc agccttcctg aaagaccaag 120 cccgcgccat ccggcttcct ccagtggacg cctgcaggac ccaggaatgt ttttcttgaa 180 ggcatccagc atctccagtt agcagtactg attttttttc cccccaacaa aggaacacta 240 catcaacact gttggcgggg acctggacac agaagactcc tgtttcaaga aaatacaatc 300 atctctcaaa ggctgtaatt tatatgcatt ttaaaactct aggcattgaa aaccacccaa 360 gtgtcccaaa tagaagggta atatataatc aatcactcag tgtaatatta tacatccttt 420 aaaaatgtta ttgggaaatg ttttatgatc tgtaagtcca aggaatcctc tcccaccatt 480 tctttccccc cgctgttccc ccatacccac acttctttgt tccaattggc atgtaaattt 540 ggttttcccg ccaaatgagt cagtcatgat gggaacctca actgatttga acagatgtgt 600 gtcaatgtta cttggaaaac tagatgtcaa taaccagggt cacagaaaaa ggcagtggtc 660 acaactctgt aaaaatgtat gcatgcacac agacaagaac taaagtggaa ccccacacag 720 gaaaacagtg ggctgtactc cagtgctggg acattgaatg actgtatgct gcttttgatt 780 tccgttaata tgggcaactg tccaattaaa aaaaaaactc ctaaggaaaa aaagaaaaaa 840 agggccggcc gcgcattttg ggctccctac acccgggtga ctataattca cgtgcccgta 900 cccatatgct aacctaagtg tccccttatt gtgaagctcg tgataaaacc ctaggaagta 960 tcgctcgtgg ccagtacgct tgtgcccttg tgtgacactt gttttccgcc caaaattccc 1020 ctaacgcttg acagtcccat caagaacgca tgaaaactcc tctcccctca cgaccagtga 1080 atagcgctta ctgccctggg caatgctgtg ccagccactg agcacagtgt tgccttaatt 1140 tgcatatgga ataccggcag actcgaacac cattcacata tttcctggcg atctgaattc 1200 cgtgtctgta aactgcttgt tcatccccct tgcccgttgt ttctttgggt ttcctaactt 1260 cacactcact cctacgataa acataatttt cttcttggat ttgtacttct tgtattttac 1320 attcatgtct ttaatccctc gagc 1344 <210> 343 <211> 1064 <212> DNA <213> Homo sapiens <400> 343 cgtggggtcc agacactcct atgttttggt cccaccatgc tgaggccagg gagagatggc 60 ctgcacctct gatctgtcca ggcagaaagg acatgggagg cctcaacccc ttcttgtggg 120 tcctggtatt tttattcagg aagggaagcc cttctctgca aactttcgct gacatattgc 180 ttaggccaca actaggtcac aggcctctgg ctggagggaa ctgaggacaa tggagttgtc 240 actttccagc ctggagagtg gagggaagca gagaggaagg tagctgggag cagatgtctc 300 gtgaacccag agccacatct gccagacctg gtgacaaaga caggctgtgt gccttcccag 360 tcatatcttg tatcatttgt tttctgtgcc agctgggctt tggaaacaaa tgcagagaaa 420 ctttatgttc ttccttcatt ccctcttgga agttgcagat ggatgccaag ggtgaatatt 480 tattgttgac ccattgaaag caaactggac aggagaaggg atgaggtggg ggaaggggct 540 aggttaaatg gatccaagtt cacacctatt ttcagtgtca aagccccaaa tcacacttga 600 gcgtctcctc aagttagaat gagcaataga aaaccagaca gccctgtatc tatgggaatg 660 ttgcttgcat cagagccacc acaccttgct gtgaggttga tcggtttctc gcagctggaa 720 atagttgctt cccgcccccc atcttcctca ctcttttaaa ctctcaaaaa tcccccagcc 780 tcccaaattt gttttaattt ttaagagaat tcttttctac aaaagaggga aaccttcttt 840 caaatggccc ttcataaatt tccctaaaga ggtttttatc tctgatagaa atatgaaaaa 900 cagataacca gataattgcc ctctatctag gctttaaaca cttattcata cattgaattt 960 ctgcaagtta cagatgattg ttgctgtgtg attactggcc ctgtctattt cctcagcatg 1020 gatgcaaatc tttctccctg agaaagtcat tgcttcgtta aaaa 1064 <210> 344 <211> 1086 <212> DNA <213> Homo sapiens <400> 344 gggccaggag gtgtgggagc gggagacact agagtaacct atgtgcacag cctctccata 60 taccatgtgc tgttgcgcct gctagtaatc gacgacatta ggcaagagaa acagcggctc 120 ctcaagtcct gcccaaagac cgtccagaaa ccccagcctc ccgtcgcctt ctcgccgcct 180 ccgctgggag ccgcagatca gtccaagttg acggacagga ggcgaaatgt gcaaatgttt 240 atggtttcat ctgtatggaa aaggagctct ggtaactttg gccaagactt ttcagtagga 300 aatgcttcaa aatacaaagc aagagctatt ttcaagaaag accttctaaa tttatattag 360 gattaagcgt ctgtaacgtt gccactcgtc gctgaggctc ctggtttcag catgtctcct 420 tggttcccag ccagctctgg gtgttcaggt agcagctgtg gctgggagtg tctctccagt 480 ccacattcct tggccatgaa ttttgcagcc ccctttatct gatgaagacc tcccagtagt 540 gaattgctca tgacattgtc acacagacct taatgaatga tatggaaaga tactgaatat 600 ttttcctccc ggaatgccaa ccaagcttca gtgtcccagc gccttcattc cagctgatca 660 tggcaaaggc ttggtactga gatccagtga gacctttgtc ctacaaaaac cacattctca 720 ctggatgcct acaagtcctc tctatgggac tgttacccaa gcctgtttac agaattttca 780 acaattacat ctgcccattt gctgagtctc acttctctgc actaattgtt gacttcaatt 840 tatattttta atgtacaaat gctatcacca acttcagtgc atgaagacct ctctttcttc 900 tcttcaaacc catgactttg cttggaataa cagggatggc tttatggcat ggctttctca 960 ttatttcatg tgtcttcatt ttgctttccc aagccagatt gtaaattcct tgaaagagga 1020 gaccctgaaa aactagaaat actatacaga cagatagaca ctaataaaaa aaaacaaaaa 1080 atctat 1086 <210> 345 <211> 1552 <212> DNA <213> Homo sapiens <400> 345 ggagtctttg tgggggcggc atgagatcag aggccacagc ggctgcagaa cataaaggta 60 aatcaaagtc ctgatctgaa accacagaga agtgggatta gagcactctt cgtcactctt 120 atgtctctct ccttttctgt gtctgtgtgt gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 gagaacaaag catgctaatg tcaacaatca atggcgtcag tcttgcctag gagagcctca 240 tttactaatg aactccctct ctgtttaaca ggcaaaatca tcatgcatga cccctttgcc 300 atgcggccct tctttggcta caacttcggc aaatacctgg cccactggct tagcatggcc 360 cagcacccag cagccaaact gcccaagatc ttccatgtca actggttccg gaaggacaag 420 gaaggcaaat tcctctggcc aggctttgga gagaactcca gggtgctgga gtggatgttc 480 aaccggatcg atggaaaagc cagcaccaag ctcacgccca taggctacat ccccaaggag 540 gatgccctga acctgaaagg cctggggcac atcaacatga tggagctttt cagcatctcc 600 aaggaattct gggagaagga ggtggaagac atcgagaagt atctggagga tcaagtcaat 660 gccgacctcc cctgtgaaat cgagagagag atccttgcct tgaagcaaag aataagccag 720 atgtaatcag ggcctgagtg ctttaccttt aaaatcattc cctttcccat ccataaggtg 780 cagtaggagc aagagagggc aagtgttccc aaattgacgc caccataata atcatcacca 840 caccgtgagc agatctgaaa ggcacacttt gattttttta aggataagaa ccacagaaca 900 ctgggtagta gctaatgaaa ttgagaaggg aaatcttagc atgcctccaa aaattcacat 960 ccaatgcata gtttgttcaa atttaaggtt actcaggcat tgatcttttc agtgtttttt 1020 cactttagct atgtggatta gctagaatgc acaccaaaaa aatacttgag ctgtannnnn 1080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncacat gtgtctgtgt 1140 ggtatatgtg tgtatgtgta tgtgtatgta ctgttattga aaatatattt aatacctgtt 1200 ggaaaaatct tgggcaagat gacctactag ttttccttga aaaaaagttg ctttgttatt 1260 aatattgtgc ttaaattatt tttatacacc attgttcctt acctttacat aattgcaact 1320 ttttttcaag gaaaactagt aggtcatctt gcccaagatt tttccaaagg tattaaatat 1380 attttcaata acagtacata caaatacaca tacacaaata taccacacag acacatgtgn 1440 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntac agctcaagta 1500 tttttttggt gtgcattcta gctaatccac atagctacag tgaaagtcga cg 1552 <210> 346 <211> 2299 <212> DNA <213> Homo sapiens <400> 346 accacccccg cgatagagga gcaacacagc tgtctctgtg cgctccggat cagcgcttcc 60 tagatttcta gccggatcgt ttggagaagg gctctgcatc ttatttccgg tggcggtgag 120 gtgcagttgc catggtgatt agagaaaggc cgagatctgt ccagctgcgg tgagaggaac 180 gctgaatcgc cgaagagaat tggctgcgct tccttgtttg tgagctagaa ttagaatggc 240 gatcagtcca cgaagcgatg caactttctc cagtcagaaa tcaacacctt cagagagtcc 300 tcgaacaaag aaatttccac taactgaaga ggaaatattt tatatgaatt gtagagctgc 360 ctacttaact gtcttcaaaa gcagcttgga aaacattatt tctaaagatc aactttactt 420 agctcttcag catgcaggaa gaaatccatc ccaaaagacc attaataagt attggactcc 480 tcaaactgcc aaactgaatt ttgatgattt ttgtataatt ttaaggaagg aaaaacctac 540 ttcaaaagca gaactactaa aatcttttaa gcaattagat gtaaatgatg atggctgtat 600 tttacacact gacctttata aatttctaac aaagagaggt gagaagatga ctcgagaaga 660 agtaaatgcc ataataaatt tggctgatgt aaatgctgat ggcaaatttg actacatcaa 720 gttttgtaaa ttatatatga caaccaacga gcaatgtctc aagactacac tagaaaaact 780 agaggttgac agtaaattga tgcgtcacca gtttggaaac cacatcgaag ggtcccctga 840 aagggaccca tcaccagtac caaaaccatc acctaaaatc acaagaaaaa ctgatccaga 900 aacattctta aataaaggtg acaccaggag ttctttactg tcagcaacca ggaagttcaa 960 aacatctgtt tccttcacag ttaccatggg ggctaatggt aaccgaaact caaagttaat 1020 ggagccaaat ttaataaagg actggcaaca catgcaatca aaaggttgct tcttcttaga 1080 agaagatggt gaaatcatta gtcatcagta caggatgcaa atagctcaga ggtccatggt 1140 ttatctaaca attaagccat taaacctgag tcaagttgaa ggaaaaccat ccccttggtt 1200 atccgttgat actgccttgt atattctcaa ggaaaatgag agtcaagcaa atctacagct 1260 tgtgtgtttt accgaactac gaaatagaga agtgtttgga tggactggtg aactaggacc 1320 tggaatttac tggttaattc cttccacaac tggctgtagg ctgaggaaaa aaataaaacc 1380 agtaacagat gaagcccaac ttgtatatag agatgaaaca ggggaattat tccttacaaa 1440 ggaatttaag tctactttat cagatatatt tgaagtaatt gatttagatg gaaatggtct 1500 tcttagcctt gaagaatata atttttttga attgagaaca agtggtgaga aatgtgatga 1560 agatgcttgg gctgtctgca gagagaattt tgatacaaag aggaatgaac taacaagaca 1620 aggatttatg gatttgaatc taatggaagc taatgatcga gaaggagatc cttgtgacct 1680 ttgggtaact ctacactcta tgggctacaa taaagctctg gagttgacag aggcatgtcc 1740 atttgtcatt gatatctatg cagaaaaatg caagccaaaa attaaagctg tccatatgga 1800 ggcatgtagt ggacaacttg agaaggccat ttgtaaatct gttcttagca acggtgatgc 1860 caaagtaatg gatggctatg aaaatataat cgtgcatact tacagttgtg acacctggat 1920 aacgtcagtt attgaaaaca agtcagatga gaaagtgatt attcacatca gcaatgagct 1980 aagtaaaaac tgcataaaca acagaggact caacatattt gcagtagaag tgggacccaa 2040 atctacaatg gtttgtcaac atgtaatgcc tttgaatgaa cgacaagaat ggatatatta 2100 ttgtatatat tctcttattt cttaaataat tatacttaga acttaccaaa ctaagaatta 2160 tttcagattt agtctgttat ttattaaaca actaaatgct acttaactga tgtacctaaa 2220 taataatcta ttcaatttat atgcattttc attttatgtc catggtatgt actttattat 2280 taaaatataa ataatgctt 2299 <210> 347 <211> 5571 <212> DNA <213> Homo sapiens <400> 347 ccagttgtgc tggaaaggcg ggaggaactc cgtcgtcctc cgcgcgcgcc tgcccgcggc 60 tggggaacca agggcctgga ggggaaacag ctccctgctg cgttgttttg ggctccgtga 120 gccgaaaggg ggaggggaga cgaaggagaa gcaaacactg cgcagcggga ccgtgcgcgg 180 cctccgctcc tgcgtgcgtg cgctcgctcg cgcgggctca gtgctggcgc gtgaggcgga 240 ggcgggcggc ggcggcggcg cctgcgcggt cggactcggt cgacggttcg caggggagga 300 ggcgggcggg aggcgggagg aggcggcggc ggcgatggag gtgaagcggc tgaaagtgac 360 cgagctgcgg tcggagctgc agcggcgggg cctggactcg cgcggcctca aggtggatct 420 ggcgcagcgg ctgcaggagg cgctggacgc cgagatgctc gaggacgagg ccggcggcgg 480 cggggccggg cccggcgggg cctgcaaggc ggagcctcgg cctgtggccg cgtcgggcgg 540 cggcccgggc ggggactacc gaggaggacg acagaggact gaggaggagg acgacggagg 600 tgctgcttga ggacgaggac gaggagccac cccctgctca agccttgggt caggccgcgc 660 agccgccgcc ggagcccccg gaggcggcag ccatggaggc cgcggccgag ccagatgctt 720 ccgagaagcc ggcggaggcc acggccgggt caggcggggt aaatggtggc gaagagcagg 780 gcctcggcaa gagggaggaa gacgaacccg aggagcggag cggggacgag acgccgggat 840 ccgaggtgcc gggtgacaag gccgccgagg aacagggaga tgaccaggat agtgaaaagt 900 caaaaccagc aggctcagat ggtgagcggc ggggggtaaa gagacagcgg gatgagaagg 960 atgaacatgg ccgagcttac tatgaattcc gagaggaggc ttaccacagc cgctcaaagt 1020 ctccactgcc tcctgaagaa gaggcaaaag atgaggagga ggatcaaact cttgtgaacc 1080 tggacacgta tacctcggat ctgcattttc aagtgagcaa agaccgctat ggagggcagc 1140 cacttttctc agagaagttc cccacccttt ggtctggggc aaggagtact tacggagtga 1200 caaagggaaa agtctgcttt gaggcaaagg taacccagaa tctcccaatg aaagaaggct 1260 gcacagaggt ctctctcctt cgagttgggt ggtctgttga tttttcccgt ccacagcttg 1320 gtgaagatga attctcttac ggtttcgatg gacgaggact caaggcagaa aatggacaat 1380 ttgaggaatt tggccagact tttggggaga atgatgttat tggctgcttt gctaattttg 1440 agactgaaga agtagaactt tccttctcca agaatggaga agacctaggt gtggcattct 1500 ggatcagcaa ggattccctg gcagaccggg cccttctacc ccatgtcctc tgcaaaaatt 1560 gtgttgtaga attaaacttc ggtcagaagg aggagccctt cttcccacca ccagaagagt 1620 ttgtgttcat tcatgctgtg cctgttgagg agcgtgtacg cactgcagtc cctcccaaga 1680 ccatagagga atgtgaggtg attctgatgg tgggactacc cggatctgga aagacccagt 1740 gggcactgaa atatgcaaaa gaaaaccctg agaaaagata caatgtcctg ggagctgaga 1800 ctgtgctcaa tcaaatgagg atgaagggtc tcgaggagcc agagatggac cccaaaagcc 1860 gagacctttt agttcagcaa gcctcccagt gccttagtaa gctggtccag attgcttccc 1920 ggacaaagag gaactttatt cttgatcagt gtaatgtgta caattctggc caacggcgga 1980 agctattgct gttcaagacc ttctctcgga aagtggtggt ggttgtccct aatgaggaag 2040 attggaagaa gaggctggag ttgaggaagg aagtagaggg agatgatgtg cctgaatcta 2100 taatgctgga gatgaaagcc aacttctctt tgcctgaaaa atgcgactat atggatgagg 2160 tgacatatgg ggagctggag aaggaggaag ctcagcccat tgtcactaag tacaaggagg 2220 aggcaaggaa gcttctgccc ccctccgaga agcggacaaa tcgccgaaac aaccgaaaca 2280 agcgtaaccg gcagaaccga agccggggcc aaggctatgt gggcgggcag cgccgaggct 2340 acgacaaccg ggcctacggg cagcagtact gggggcagcc tggaaacaga gggggttacc 2400 gtaatttcta tgatcgatac aggggagact atgatcgatt ttacgggcga gattatgagt 2460 acaacagata cagagactat tacagacaat acaatcggga ttggcagagt tactactacc 2520 accaccccca ggacagagac cgatactaca ggaattacta cgggtaccaa gggtatcggt 2580 gaagcccctg ccatggtcac ctgtcagcca tgaagctgaa tctctggggg tgccaggcac 2640 ccccgcaaaa cacaaccaag gaaaacaggg gctgtcgggg tggggctgag ctgccgggga 2700 ggggtggtgg ggggggaggg tgctcaagca ggggtggggg aggggggagg tggaaacaaa 2760 caacaaaact gtacattttt tttaaagttt gttgaaaaga atattgtctt attctataaa 2820 acatttcaaa cctagttaga gatttgtaat caaaaaacat ttgcgcagaa agcagcactt 2880 agggctgcct gttctatacc ctacagtcag acaggaaaag aactgaaaat ggcacccttc 2940 tgacattctg aggcagctgg actggcagcc aagtaaagga gagtgatgag gtggtgtggg 3000 gagggtgggg aggcagcgcg agggtgctct ccacagcagg taggagcagg caggagtggg 3060 gacagaggga gagcttgtga ctgggacagt gaaaataaac gattggctct tatcaatcac 3120 ttgcaccaac taaccgtttg tattttcttt accgaccttt cccttttggg atatgtggtc 3180 tggtgggctg ggaggcttac agtgtcccaa ctctccattt tcctgtgcct ttgtgctgtt 3240 tggctgaggc atggagactg ccagtgggtg gttctatttt acaggattcc caggccaaga 3300 aagcctgggg actgtccttg atggcagagc agaatagcct gccccttcta tagacccatt 3360 gattaattcc tgtaaaatct tggggagaat gggattgcag ccctcagcct aaagattgtg 3420 atttgccagt ctctagtctc tgtcttccaa ggttgagaga ggtgggaggt ctctgaaatc 3480 atccctgtta gagtgtctgt cctcttacag tgcgagagaa ggaacgtttc tcagggtttc 3540 agctcacacg aaaacacagc aggattcttt tcactgcagc gggatatgta tataggtgaa 3600 tcctgtggtg tgggctcaca ggcccaggtg ctgagaatag caactagcaa ctattttcta 3660 cagtgtggag ggctcgtgcc ctgctggttt ttttgataca caggtagaga atgaatagaa 3720 gaggggaggg tggtgggggg gggtgggagg cagctcagtg gggctgctga accttgggaa 3780 gagtgtgagt gtgaacgtgt gtaaatgtgc gtgtgaaagg gagcacccct tcccgacttc 3840 tagaaacaaa attccttttg gggcgctttc cctgtgtgtc cccagagagg cctctagcca 3900 ggagccttca gttgggatag tttcatttgt gactttacca ataccctccc agttcttgat 3960 agacagctgt aggttgctgg gttcaagaat atgggtggga tatggaatgc tctttcaatg 4020 tctagcttca gttttcattc atcctcctgc tcagcactgt cagccaagag cttactcagc 4080 agacaccaca tactgcagca gttcctagtg agaaaatctg tgccactaga aaatgcttca 4140 cttccatttc ctcacctggg cagttctctg tttaaaattg tgggctgatt tggtcttcct 4200 ctcctcctcc cactgttact gccctgcagc ccttgttcag gtgtacagac ccttattctg 4260 gcctctagtg tccttgtctg tcatgacaca cccttccgcc caaatacctc tgaccccaag 4320 gctggaatgg ggctggtagg agataagttt gcttactcat agtcatgtcc tttctcttgg 4380 cacctgcttc cctgcggtgt cctcaaatgg atttctgtgt ggcagtggag tgattgcatg 4440 aatttttctg taacacatta actttgtatt attattaagg gagtttgaga aagctttgct 4500 tataatgtca aggcaaggag gtaaaaactg gagcccaaag aaattccctt agggcaagat 4560 tatgttataa tagaaaattg aatttcctga ggcagtggct gccaccccct tttcagatgt 4620 ttagtcctgc aaatagcatc tttcttgtag tctgtgacat ggatggggat gctagggccc 4680 ttaggggcaa ggggactaaa ctaaatcaag ttgagttttt ttccagcagg ggttagggga 4740 ggtactcgct gttgatattt gacactagaa agtaatcttt tttacaaaac tgtttttcta 4800 ggtgggtgga aagtgaaact gccacatcct tgttggttta gtccaagaga tcatttgcaa 4860 caacagtaga tgtccgggtt ttgtttctgt ctttttatta tgaaaaacta tgttaagggg 4920 gaaaatgtgg attatggtaa ccagaggaat ccctagcctt gttttcctta gaagacttgt 4980 ttagtgtttt atcagacgtc tgttgtagtt gtagacagga aagcttgtga gaaaaacacc 5040 acatggagcc tgtaaatgtt tttgcacaac ctgtaaagca ttcttggaag tggccagtaa 5100 aaaggggttt taccatttaa aaaaaaaatg taactgtgtc attgtttaca tctgtaactt 5160 tttcctcccc tgttctcatt acaccattct ggcgaaaatg taggcaaagt agcttccagt 5220 tttagaataa ataaccattt ggattgaaaa anaaaaaaaa aggcccaacc tgggacttct 5280 aagcctccat attctggaag nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn catgatttcc aatgactgca ggacccaagt 5400 tcacaatgca agggcagttc tggaaaaggc tggcattctt cagtaggaaa ggaaacatta 5460 agctgtgtga ttttaccttg aaatccccgc tattagtttt gatagaattt tctttggtca 5520 gaaatgtgtg attcacaaac taaaatttcc taaaaagtta actgtggtgc t 5571 <210> 348 <211> 2418 <212> DNA <213> Homo sapiens <400> 348 gtttttctgt cctcatgcat ttgtctttgt ggctctttcc gtctttctgc ccttgacacc 60 atcccctctc ccagtgcttc ccctctgctt ccagatcgct tcatgactta ggcagggaaa 120 cagaggtcag ggcctccttc caggcttccc tctgcatctt actgagtatg caggtcggaa 180 gagcctcggg tcctgcctcc gcgggtggcc tagagccaaa ggaaggcgga cccgtcgggg 240 cgggattagc ccttagggcc acctcataaa gcctggggcg aggggcacaa cggccttggg 300 aaggagccct gctggggccg tccagtcccc cagacctcac aggctcagtc gcggatctgc 360 agtgtcatgc ctgggagccc tcggcccgcg ccaagctggg tgctgttgct gcggctgctg 420 gcgttgctgc ggcccccggg gctgggtgag gcatgcagct gcgccccggc gcaccctcag 480 cagcacatct gccactcggc acttgtgatt cgggccaaaa tctccagtga gaaggtagtt 540 ccggccagtg cagaccctgc tgacactgaa aaaatgctcc ggtatgaaat caaacagata 600 aagatgttca aagggtttga gaaagtcaag gatgttcagt atatctatac gccttttgac 660 tcttccctct gtggtgtgaa actagaagcc aacagccaga agcagtatct cttgactggt 720 caggtcctca gtgatggaaa agtcttcatc catctgtgca actacatcga gccctgggag 780 gacctgtcct tggtgcagag ggaaagtctg aatcatcact accatctgaa ctgtggctgc 840 caaatcacca cctgctacac agtaccctgt accatctcgg cccctaacga gtgcctctgg 900 acagactggc tgttggaacg aaagctctat ggttaccagg ctcagcatta tgtctgtatg 960 aagcatgttg acggcacctg cagctggtac cggggccacc tgcctctcag gaaggagttt 1020 gttgacatcg ttcagcccta gtagggacca gtgaccatca catcccttca agagtcctga 1080 agatcaagcc agttctcctt ccctgcagag ctttggccat taccacctga cctcttgctg 1140 ccagctaata agaagtgcca agtggacagt ctggccactg tcaaggcagg gaaggggcca 1200 tgacttttct gccctgccct cagcctgttg cccctgcctc ccaaacccca ttagtctagc 1260 cttgtagctg ttactgcaag tgtttcttct ggcttagtct gttttctaaa gccaggacta 1320 ttccctttcc tccccaggaa tatgtgtttt cctttgtctt aatcgatctg gtaggggaga 1380 aatggcgaat gtcatacaca tgagatggta tatccttgcg atgtacagta tcagaaggtg 1440 gtttgacagc atcataaaca ggctgactgg caggaatgaa aacaagaaca tactgtggct 1500 gtgtatcctc tacttcccct gtctcaactc atcctaatcc tctgatacac tttcatctgt 1560 ttgggggagt catttgggag acacagaatc actcaatgtg agagccagaa tggactaacc 1620 tgccttccaa tgctgttatc ccctctatac catttctggc agagggtccc acctggttag 1680 cacacctctt tgaataagaa tgcacttact gtctcagaat aggtactacc tctccaagtt 1740 aactatcctt aatgccctca actgatgtcc ataaggcttc tcttctgtct cttttaaatt 1800 actaacatct tcattcctat ttcagaactt tttaaaagcc acaaagcctt tttcttacag 1860 agctgaaatc cccctttgtt ggctttttac accacagaga ggtggtcctc tcttgagggc 1920 aaatttcagg atagagcacc ggagagaaat aacacaaagg cccttgaggg gaaagcacgg 1980 taggtaggga atatacctgg caattaaggc agtttttttc cagcagccag ccctgctaga 2040 tgctacagca ggaaaaagcc agttttgatc cccagagagc cccctgtacc cttcagctga 2100 gtactctcac cattgtgcct tgggctccct gagattcccc aaccaaagga ccctcagggc 2160 tcctcagcct ctgcaaggct tccttggctt gccctgaaag gaaaagtcct tgatattggc 2220 ctctaggatt tattaaggac aagagcttag agtttcagag cttctccctg ggggaagctc 2280 tggcaaagat gacagagatg gttcttttca atgcccaagg ttgttttgat atgtggtctg 2340 ctggtgagca agggcattgc aacaatgtgt ccagaaggct ctttgatttg ccgaaatggt 2400 gtaaatggca gacccttt 2418 <210> 349 <211> 2788 <212> DNA <213> Homo sapiens <400> 349 caaatatatg cccagggcat gctactttaa aaatccgagg aatctccaac aaggtgctgg 60 attaaaatca gatttcgtgc ttgaagtgga agaaaaatga agttgtttat ggataagaga 120 gtgagaatgt gtatcctcaa gtacgttaag atgatttaac tgaaagatgg ctttaggttt 180 ttcttgaaga attaggaaag taccatcccc acagattcag catactcttc aggtactaga 240 taaaggtgaa ggaagtcatg gaattaaaat gacttagcaa ctccccaggg aacttgtggg 300 gagaatgagg tggttagaaa ggtgagaatg cacaaagaca gctctggggt tgggtaccaa 360 cagtttgctt ggtagaaaga aaccagtgta ggaaaggaga cgccaccaga catcttcaac 420 agacaagatt ctttctgcct ttttcaaaag atgctctctg cagcagtaag actatagata 480 gagttgattg gaatatcatg tgacccagta tgctactgct aggcataatt atcaaaaatt 540 catttttctc attaaatatt gttaattgct cgccacataa agagaagcta gagctcacca 600 gtcttggtgg tgtcctagac cttcctctaa agcagtcttg ggaagctgga tcatcagatc 660 tttagcctag acagagtgtc gctggtaaat aaaggagaca caggtaaccc agagtggaca 720 gtgatttgcg tggggagaca cagtggatct ggggcctctg atactttgct tcctaaaaca 780 gcccccagtt ttcggcttgc cctatgagat gatgttcatg tgcttccttg aaaccaggtg 840 gaaagaaagg ggaagaatta attttctcat tctgttgctg ttgaacgtaa tgtaatctta 900 atactgtagc cttcctagaa gcccttccct ctttttcatg ctgtaaagtc aaatatttga 960 tatccttaac ataaatttta aaaattaagg tcattaggaa gcaaatgtct atttccaaag 1020 caatgagctt gttgtgactg tgattttatt cttctatagt atttttttcc tcattttaac 1080 tgagaggaga aaataatact cttttgcaat atccttaggt tctccccttc cccctggtgc 1140 cccttctagt gtcttaagac tttgtcttaa caagtataac attacatttt gttgttaaaa 1200 cctttcgaaa ctgtattcag tgattcttcc aagtttatct gctctgcact atttcactaa 1260 taaaccctgg ctaccacgta gcccttgatc tccaagtagt ttacctatgc aagacctgtg 1320 acactctgaa ttcacttctc tttctttcag aaagtagtca taaatggagc ttaattataa 1380 aggtaaaact tgtctccaac cagtttcatt ttggccattt ctttttcaaa atgtcagctg 1440 ttttcctcca agatttttca ccaaaacaat gatcataagt gctggaatat ataatacttt 1500 gcaggcataa aataacccag acatactctc atatttcttt ggtgtatttt ggttggtaaa 1560 acttaccagc attaaatgta aaatataatg aggagttaat tccttaccta gaactatttc 1620 ttccttttaa gattcataag taacctttta tttttacaga gctacgtata acttccacat 1680 tacagtcagg gacctgaggt gtaacttact aagtgaaccc caaggttatt ttatcttgca 1740 aaagaaacct aaaccaaact aagggcctta cagtttatgg ttagactgaa tcaaaagcta 1800 taacctcaat ttttccaaaa acagcttctg actgcaaaag caagtcatac agttgttagg 1860 tatgaaatag cactgatcag gaaatgcatc ttcgcagatg gtatttcctt cagaaaagac 1920 ttttctactt ttaatataaa ttaagccata acagtttcat gctgtggaaa gagggtgaaa 1980 aggttcattt taagagatta tataatatga actttcacat ttactgtgaa atgtctaact 2040 ttgccagtgc ttcagcaagt ttttttgggg ggtgatgggg aggggtagta ttggttttag 2100 aggtttcaaa tctgtgaact ttggagaggg gacagttgtt ggctctggta tttactagtt 2160 ttgtagtaac gttttgctag cctgactgac ttttcttact ggtttttatg cccacggtcc 2220 gaggggactg ttcttcttgt tgggggtgtc tgcggaatag cgtctcgtct tgtttgtata 2280 ggcagtcaat gtgtgtgaca tgtgtgtcct ttcagtccgg aagcccactg tgtgacaatg 2340 gcgtggggtg tggctgggag gtggggtgct gaagcttgaa gagcatttct ttgctgattc 2400 ataacagtat ttcccatctt ttgcctgcag gcagggaaag tgtacagtat ttattttgtt 2460 tctgttttac tttaaatttg taagtcttta agtagcttac attgattatt ataggggagg 2520 acaagtgact tgtttaaagt tgtatttagt attctttcca atttctgtat tttaaaatat 2580 tgaaattaaa attgtattac ttctgttttg atttttttag cactcagtgt attttttgct 2640 cattttgttt gaaagtataa atgttgaaaa ttgtataaaa tgcgtccttg aaagaaaaag 2700 aatctgaatt ctatatccaa ttctgacttt gttccctttt tctgctgatt gaatcatggg 2760 aaattattta aaagtatgaa aaactggg 2788 <210> 350 <211> 4363 <212> DNA <213> Homo sapiens <400> 350 tgctgattta gtaccatcca ttgctgcaac accagattac gacaatactg catgatttaa 60 cacacaacca cacacacaaa gcacacgcgc acacgcacat acatgtacaa agggatattt 120 tggtggtggt ggattttttt ttgtcttttg tcttcctatt cacattacaa aaggaaaggg 180 caaggttctg cagaactgac gaaggaacta acagatacta caaaaatatt acaatttgtg 240 aagattagct caaccctctc agcttttatg aatggagcgg ggaggggccc aggctgagtg 300 ggaagggcat gggagtgagg gggccagcta gttctatgga atagtttgat ttttttctct 360 tccttcccca ccaatgttga atgacatctt gctgttaaaa atactgtttt ctgggattta 420 cagatcccct gagggccagc caggaaagaa gagttggagt gagatgaagg aaggactatg 480 acaaatnnnn nnnnnnnnnn nnnnnnnnnn nngaaggaaa aggaaacctg gtagcttttt 540 ggccttggat tctctctggg ctccagatga cctggatgcc aagccactgc ccctcctctg 600 ggggcctcca ccctcctctc ccggctggag gtttgcctga ttttctggga tggggttggg 660 tattttgttc actcaaatgg tggcacattt ttctccttcc ttcacccaga ccttctttta 720 tgtgtccaga aatggaggct agaaagcagg tgagaggtcc tctggtcaga gccacacggt 780 ctgtgccggc cttcctccac caagaccccc aggagatgaa gggagggagg aggtgagcca 840 gaagggcgct cccctgctga tgggtctggg ctgggtcact agctgctcaa aatggcagct 900 ctagtttgct ggcggctgac tggggaggag aagggctctg tttctcttcc caccactcag 960 cccacctgct gctttcctct gctttgccac atctgggtgt cccccggtgg tctctgagag 1020 cctcaggacc cctgcccctc ctccagctct ttgttcccag cctccccttg actcctgtcc 1080 tccaagtccc aggggagtcc cagcccctca gggacctggc ggtgtctcca tccttctccg 1140 gttccctagt gggatagctg cctctgactt cagggtccct cctaccctca gccttctgag 1200 aacacaaaac aaatccaata ccccacccta gtccagcacc atcgtgagca agattcctgc 1260 tgcgctgctt ccaaaatgga aaagcatcac aactaaatac ctaatatcct accaaacaaa 1320 ccacagtccc tacgtagccc tacttcagtc ccaggagaag gaatccatga atgggctgag 1380 gttccgaggg taggttgtgg atgtctttct ctagaggggt cccacacctg gaaaagagga 1440 cacccagccc gtgggatgag ggaagctggg caagggagaa agttgttgag tcacactggg 1500 gaccccagat gtagtgagct cagcaagaaa agccaggtcc agagagagtc gcacagaatt 1560 cctgactcac agcgcccctc ggtccacagt ggannnnnnn nnnnnnnnnn nnnnnnnnnn 1620 nnnnaggact gcaggaggag gaggatctga aagcgctttg gccttgtgtt atgttttgct 1680 tcttttctgt gtcccctgtt agcacattgt acttgaatta cctcagtttt ttgtgacctc 1740 atgagctttc ttaacctctg tatctctttt tcggttgggg cttggaggaa tggggagggt 1800 gttcttttct gtttcttgtg taaattaata gttgttttta tagacttcag ctggtcaaga 1860 ccctccccgt gcccctggag accagcctcc cagctggcag gaactgtgca ggaggagttg 1920 atactcagga tctgaatgtg agggccgagg agggcgaaga gcgtgggtgg ggaggggatg 1980 ttgctttggg gtctcatggt ccccagaggg cactagggag tcacttttgg ctccgctggt 2040 gcatgaagtc acctgtggcc accatccgtt ccgcctaaaa cactctggag agaatcccac 2100 ctttcttaca atttgctggg ccattgaggt ttgagggcct gtgtttggat ccttgcaact 2160 gtgtggtctc acctctgtgc gtgcattctc attgccagaa ttggtctatt ttcacggctg 2220 gtctttgggg aggggggcgg gatccagcct ttgttttgtt gtgttggggt gggggtgttg 2280 tttttctaaa agctacctct tatgtttgtc cagttgttct tttgttcctt tcccgcctcc 2340 cattctgctg ctcttcctcc ctcttttccc caacctcccc cgaccctcct gaattttgga 2400 aagcacattt gcaatattcg tgtttgcttt gggacggacc ctccgtttca tctcatgctt 2460 tatgtgtaag agttttttat tattattttt tctttccttt ctctctctga gaaagttgtg 2520 gctgcgtttt gatcttaggt tttacaaagt ggtttaggga agcggttttg gggagaagga 2580 tcacgaggaa tgtagggaag ccggagggat gggtgctgct gcgacgaccc ccccgtccct 2640 cggccccagc cctcctgccc tccccttcaa tctcatccac caaatctgaa ggccttaaaa 2700 ttgtgtgttg ggaggatgtg aattgggagg acggtgtcac tagactgtgg attagggatg 2760 gtaaagtagg gaggatgcta ttttgcaact atagtaacga cttagtgttt tggaaaggaa 2820 aagaagttaa acttgaaata cgtgactaga acagttgtca tgtttataat gtgaaaaggg 2880 tgaaatcatt tgggggaggg gccgtctgta agaaatcatt atgcactatg gcttcctcct 2940 ctggtctggg aagaagcggg gactggctgg ccctcagggg atctgtaaat cccagaaaac 3000 agtattttta acagcaagat gtcattcaac attggtgggg aaggaagaga aaaaaatcaa 3060 actattccat agaactagct ggccccctca ctcccatgcc cttcccactc agcctgggcc 3120 cctccccgct ccattcataa aagctgagag ggttgagcta atcttcacaa attgtaatat 3180 ttttgtagta tctgttagtt ccttcgtcag ttctgcagaa ccttgccctt tccttttgta 3240 atgtgaatag gaagacaaaa gacaaaaaaa aaatccacca ccaccaaaat atccctttgt 3300 acatgtatgt gcgtgtgcgc gtgtgctttg tgtgtgtggt tgtgtgttaa atcatgcagt 3360 attgtcgtaa tctggtgttg cagcaatgga tggtactaaa tcagcacctg gatgccccac 3420 ccaaccccgt gggccctgca gaccccagta gggaggtatg gggagagctc aggggagtgt 3480 ggtttctgag ggctactgtc tggggacacc tctgaactta ctgtaccttc ctctccccat 3540 gaagacacct gaatagagtc taacatgcct cttctccaac ttcctaccta caacaacaga 3600 acagttctaa tgttgcacgg cctagtggcc agggggcaag ctaagaggct gtctggaggc 3660 tttatatgtg tctggagtta aggggagagg aggagggtag acaggggtct ctccccaggt 3720 gggatctgaa tatctgtcct cccctcttct tcatgccacc tgactccttc ggccccctgg 3780 ctgcctttag ctgtggtact gctgacaacc ctgcttgcta ctgccttatc cagcacagtg 3840 aaaaacttct ccagcctggc aaggccacgt tggttaatag tccctttccc atgtccagct 3900 cctacaaata tgtcccttaa tgcatttggt gacatttaca cctcactcat gtgctctttc 3960 cctattcact ccttcactca ttcaaagcat taaaatccta tgtatatata ggatagacaa 4020 atatatagat atatagatat atatatatat agcaagagat tgatataaaa tagtaaatat 4080 cattgctgct ttgggctgct ttggaggagg aggccatgaa tatggggaag gcagatctgg 4140 ggtgcagggg taggtaggga ggctggggga cccagtgatt cagtacaatc caagggatgc 4200 aacgcgggct tgtttaatct ttgtgcctga acagtttttc catgttgaga aaaaaaagaa 4260 aaaaaaactg ctgcaatttt tcacaagtgt atggtacctt tctggatgct attggtacaa 4320 ttgctgtgga tggaagaggg ccattgagct tacctccagc cgg 4363 <210> 351 <211> 789 <212> DNA <213> Homo sapiens <400> 351 atcaagccac ccatctcagc tacagcacag atcaggtgag gagcacacca aggagtgatt 60 tttaaaactt actctgtttt ctctttccca acaagattat catttccttt aaaaaaaata 120 gttatcctgg ggcatacagc cataccattc tgaaggtgtc ttatctcctc tgatctagag 180 agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctggg tgtcagcagc 240 cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat gtggagagcc 300 tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca tgctcggggg 360 aactatgatg ctgccaaaag gggacctggg ggtgtctggg ctgcagaagc gatcagcgat 420 gccagagaga atatccagag attctttggc catggtgcgg aggactcgct ggccgatcag 480 gctgccaatg aatggggcag gagtggcaaa gaccccaatc acttccgacc tgctggcctg 540 cctgagaaat actgagcttc ctcttcactc tgctctcagg agatctggct gtgaggccct 600 cagggcaggg atacaaagcg gggagagggt acacaatggg tatctaataa atacttaaga 660 ggtggaattt gtggaaactg tgtgttatac tttgtggtat agactgcctg tttagtatga 720 aggggcgatc catgcacatc taagtgaacg ttgaggctag cttggtggga gacgactcct 780 gggcacaca 789 <210> 352 <211> 1405 <212> DNA <213> Homo sapiens <400> 352 ctccctggtc tatatgaaaa tttattacta cagtgttttc accattaata tttatgatct 60 tggtctttcc ttcttgcctt tgtatagggc caaaagagaa acattggcta ctttgacaac 120 cttaaagcgg actccaggaa tatcaccaac agcatgacct ttgcgaccaa atccagctga 180 aaactgcagc ttccttctca ccttgaagaa taatcctaga aaactcacaa aatgtgtgat 240 gcttttgtag gtacctggaa acttgtctcc agtgaaaact ttgatgatta tatgaaagaa 300 gtaggagtgg gctttgccac caggaaagtg gctggcatgg ccaaacctaa catgatcatc 360 agtgtgaatg gggatgtgat caccattaaa tctgaaagta cctttaaaaa tactgagatt 420 tccttcatac tgggccagga atttgacgaa gtcactgcag atgacaggaa agtcaagagc 480 accataacct tagatggggg tgtcctggta catgtgcaga aatgggatgg aaaatcaacc 540 accataaaga gaaaacgaga ggatgataaa ctggtggtgg aatgcgtcat gaaaggcgtc 600 acttccacga gagtttatga gagagcataa gcccaaggga cgttgacctg gactgaagtt 660 cgcattgaac tctacaacat tctgtgggat atattgttca aaaagatatt gttgttttcc 720 atgatttagc aagcaactaa ttttctccca agctgatttt attcaatatg gttacgttgg 780 ttaaataaac tttttttaga tttagaaggt gatgtaatga tgtattcatt gtgcttatga 840 tgtattctta gtcataactg agtgaaggaa atgggaaatt tgcattattt ctttgttctg 900 atatgaataa taacatattt cataataatt caaggtaaaa agggatatct atggatttcc 960 ctaggtagga gataacaagt atgtaccatt actgaatatt aaatccttct ttaccatagc 1020 tacagttaag taggtgtatc tcagaaacct aaggtagttt taaatgtagt gaaattgtcc 1080 acagcaagct ggcccaagtg ctcacatttt atacccgctc tgtcttagtg cgttgcaaga 1140 gaggagtata tacagtagtt cccccttatc cacaggggta cattctaaga ccccccggtg 1200 ggtgactgaa accacagata gtaccgaatc ttatacatac tatgtttttt ttctaaacat 1260 aaatccctac aataaagttt aatttttaaa ttaggcacca taattaataa taaaacagaa 1320 cagttataac aatatactat aataaaatta tgggtatgtg atctctcttt cgctntcccc 1380 tctcnaattt tttanaganc ccccg 1405 <210> 353 <211> 3109 <212> DNA <213> Homo sapiens <400> 353 gctgagggta gctgggggcg agagcgaggc tacggagcag gcgagaggcg acggcgagag 60 ctagagcggg cgcagcgtta gggtggccgt gcaaggggag ccgtggcccg ggcccggggc 120 gtgcgagacg gcggaagcag cccagggcct tgctgccgcc atgactgagg aatcagagga 180 gacagtcctg tacattgagc accgctatgt ctgctctgag tgcaaccagc tgtatggatc 240 actggaagag gtgcttatgc accaaaactc ccacgtgccc cagcagcact ttgagctggt 300 gggcgtggct gatcccggag tcactgtggc cacagacaca gcttcaggca cgggcctcta 360 tcagaccctt gtgcaggaga gccagtacca gtgcctggag tgtggtcaac tgctgatgtc 420 acccagccag ctcctggagc accaggagct gcacctgaag atgatggcac cccaggaggc 480 agtgccagct gagccatcac ctaaggcacc acccctgagc tccagcacca tccactacga 540 gtgtgtggat tgcaaggctc tctttgccag ccaggagctc tggctgaacc accggcagac 600 gcacctccgg gccacaccca ccaaggctcc tgcccctgtt gtcctggggt ccccagttgt 660 tctagggcct cctgtgggcc aggcccgagt ggctgtggag cactcatacc gaaaggcaga 720 agagggtggg gaaggggcga ctgtcccatc tgccgctgcc accaccactg aggtagtgac 780 tgaggtggag ctgctcctct acaagtgctc tgagtgctcc cagctcttcc agctgccggc 840 ggatttcctg gagcaccagg ccactcactt ccctgctcct gtacccgagt ctcaggagcc 900 tgccttacag caggaggtgc aggcctcgtc acctgcagag gtgcctgtgt ctcagcctga 960 ccccttgcca gcttctgacc acagttacga gctgcgcaat ggtgaagcca ttgggcggga 1020 tcgccggggg cgcagggccc ggaggaacaa cagtggagaa gcaggcgggg cagccacaca 1080 ggagctcttc tgctcagcct gtgaccagct ctttctctca ccccaccagc tacagcagca 1140 cctgcggagt caccgggagg gcgtctttaa gtgccccctg tgcagtcgtg tcttccctag 1200 cccttccagt ctggaccagc accttggaga ccatagcagc gagtcacact tcctgtgtgt 1260 agactgtggc ctggccttcg gcacagaggc cctcctcctg gcccaccggc gagcccacac 1320 cccgaatcct ctgcattcat gtccatgtgg gaagaccttt gtcaacctta ccaagttcct 1380 ttatcaccgg cgtactcatg gggtaggggg tgtccctctg cccacaacac cagtcccacc 1440 agaggaacct gtcattggtt tccctgagcc agccccagca gagactggag agccagaggc 1500 ccctgagccc cctgtgtctg aggagacctc agcagggccc gctgccccag gcacctaccg 1560 ctgcctcctg tgcagccgtg aatttggaaa ggccttgcag ctgacccggc accaacgttt 1620 tgtgcatcgg ctggagcggc gccataaatg cagcatttgt ggcaagatgt tcaagaagaa 1680 gtctcacgtg cgtaaccacc tgcgcacaca cacaggggag cggcccttcc cctgccctga 1740 ctgctccaag cccttcaact cacctgccaa cctggcccgc caccggctca cacacacagg 1800 agagcggccc taccggtgtg gggactgtgg caaggctttc acgcaaagct ccacactgag 1860 gcagcaccgc ttggtgcatg cccagcactt cccctaccgc tgccaggaat gtggggtgcg 1920 ttttcaccgt ccttaccgcc tgctcatgca ccgctaccat cacacaggtg aataccccta 1980 caagtgtcgc gagtgccccc gctccttctt gctgcgtcgg ctgctggagg tgcaccagct 2040 cgtggtccat gccgggcgcc agccccaccg ctgcccatcc tgtggggctg ccttcccctc 2100 ctcactgcgg ctccgggagc accgctgtgc agccgctgct gcccaggccc cacggcgctt 2160 tgagtgtggc acctgtggca agaaagtggg ctcagctgct cgactgcagg cacacgaggc 2220 ggcccatgca gctgctgggc ctggagaggt cctggctaag gagccccctg cccctcgagc 2280 cccacgggcc actcgtgcac cagttgcctc tccagcagcc cttggaagca ctgctacagc 2340 atcccctgcg gcccctgccc gccgccgggg tctagagtgc agcgagtgca agaagctgtt 2400 cagcacagag acgtcactgc aggtgcaccg gcgcatccac acaggtgagc ggccataccc 2460 atgtccagac tgtggcaaag cgttccgtca gagtacccac ctgaaagacc accggcgcct 2520 gcacacaggt gagcggccct ttgcctgtga agtgtgtggc aaggcctttg ccatctccat 2580 gcgcctggca gaacatcgcc gcatccacac aggcgaacga ccctactcct gccctgactg 2640 tggcaagagc taccgctcct tctccaacct ctggaagcac cgcaagaccc atcagcagca 2700 gcatcaggca gctgtgcggc agcagctggc agaggcggag gctgccgttg gcctggccgt 2760 catggagact gctgtggagg cgctacccct ggtggaagcc attgagatct accctctggc 2820 cgaggctgag ggggtccaga tcagtggctg actctgcccg acttcctctt tggcacctcc 2880 attccctgtt gctgaaggcc ctccagcatc cccttaagca tctgtacata ctgtgtccct 2940 tcctcttccc atccccacca ccttgtaagt tctaaattgg atttattctc tcgtgagggg 3000 ggtgctctgg ggtccttgac acacataaag gtgccccccc accttccacc tcttagcact 3060 ggtgacccca aaaatgaaac catcaataaa gactgagttg ccaaaaaaa 3109 <210> 354 <211> 2626 <212> DNA <213> Homo sapiens <400> 354 ggagatgtcc ccagaccggc cctgcccagc tggagaccag cagtgaggtc cagagcgagc 60 cagcagtccc caagccggag gatgacactc ctgtccagga cactaaaatg tgaagaacag 120 ctcattgtgc cccagtgatg aagttgctgg acacatctct ttgcaggtag cagcaacagt 180 tgtagcagca gcagacgaag ccattgcaga ggcagaatat gctgagtgtc tggagtcagc 240 ctgaagacac agggtggatt atttcctggc ctccacacca aacgttccct tgcagatgga 300 gactgaatct gagggcagca gacttttatc agcttgagtt tatgtcattt gatggacttg 360 gttcaacaac aagaacttac ttaaaacaat gtactgtggt gatgagtccc aggggcactg 420 gtcagcctgt ggagccctgg atgctatcca cacccaccta tccctgcagc taatttagct 480 gatctctaat ttaactgagc tctaatttag ctgatcagat tttgcttggg taaagttcct 540 ttttaatgtt ctaaagtgtt tacggttctc aaatatcagt taaaaactaa ttttaggtgg 600 ccataaacat aaaatagaaa ccctgtaagt tacagaagac cctaaattgt atcaaaaccc 660 tagagacaac ttttcaattt gatccaaatt tgaactggcc aaccagtctt taaaacactg 720 gactagaaga gataatgatt gaaacattta aaaaaaaaaa gtgctccatt cgcaggagct 780 tttcctgtcc tgtggttttc cagttggtga ccaccatggg aggtcgctgg ctcggctcac 840 tcccttctcc cacccttgag aatgtggaga actcccatgg agaggcagaa tggcaggagg 900 tttcatgtcc cgcgttgcat ctcctcctga aagaaaagca gtgatacctg aataatgctg 960 gctctccgat tgatcctgtg aggatgaatt tgcatttcca gaatccttga gcatggatta 1020 gatgtttcct gggaggtgcc ttgagtacca ttatgtgcaa gctacataat taaaacattt 1080 ttcttagttt ccctgggaag cttttcttga ctcacagccc aggttcttct gcccaacaca 1140 aaaggagtga gttggggtct ttagtctctt cttattgggt agctcttgct ttaatattct 1200 gtttggtgag tgtaagggat tctgcaaggg acagggggcc tgactaccca gtctttgact 1260 tgtatcctct cccctcttca tacactcctg ctgaaaaatg ttaatccaaa tacacattta 1320 aacttagggt cggtccttat tctgatttga gtattttaat gtctcagtgt gctgatttgg 1380 tagttggaag aattattctt ctggaggtct gttagactac atcctacact gacttcagaa 1440 aacagtctgt cagacaaaaa ggccttatgt caccactggt acctcagttt cctcatccca 1500 tttacagttt ttctaactcc agggtagtgt ttagtgttaa tatttgggat atattttttt 1560 tcaaaactgt ttttaagtag tttgtaattt gtaacaaact tgtaacctgg ttgggactga 1620 tattgtcata gctatgataa actttggata ttagcagaat ttgggagatg tgtgtgtcaa 1680 ttattttgag atctataaac tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tgctatcaat 1740 ctagctacca tccatttatt gacagagaag tctaccccta aacaatactt ggttttattt 1800 atatatgtct ttgggttgtt tatacacatg cactatctgg gcaagtactt tgtgaatatg 1860 tgcatgattg tgaatgtgtg atgaaaaggg ccactttact tgaggaaggc atggaacaga 1920 aagtatgggg tttagatatg aaaaatgaaa ctgcattttt cttctggagg gtctaaacat 1980 agtagcagac gagagagggg cagtaaaaat gacaagaatg tgacattgcg gcaccatgct 2040 tgtgggcatc agaatacctt tctatccccc aagtctcctg ttagtcacat tatttggtgt 2100 attttgtgaa aaaaatagag gccccattcc cagggcttgt tcattaataa agggggctct 2160 tggcagggaa ctcatgaagt acagggactg atttttgttg gtgctgcagc cccactgctt 2220 aaaactctcc tttctcaaag caaccatgat caggtgtttt atttgcatgg ttgatactgg 2280 aacttctaaa tttgggatta aagaaattca tctgtgtctt aggtagcaca aagttattaa 2340 caggccagga agaccttgtt tctttcaggc ttccataatg ggtttgaaag aaaacacgga 2400 ttcttctaca gcaacagagt taaagaaata gtcatagtca ttcttccacg atctttgtag 2460 tctagcttga atttcaaact gtgtccttcc ttactccaga gagggagcaa gaaaaaaaac 2520 ctggatgctt tgaagggatc tgcaactatt taaaagggga ttaggattct gtttcagctg 2580 catgtggaac taggtaagct tcagtggcct cagaactcca ggcccc 2626 <210> 355 <211> 7959 <212> DNA <213> Homo sapiens <400> 355 actagtgtct agggggacca cagtggggca tggctgcatg gaaaatatcc gcagggtccc 60 ccaggcagaa cagccacgct ccagtgccag gctgtcccta ctgcctggtg gagggggaac 120 ttgacctctg ggagggcgcc gctcttgcat agctgagcga gcccgggtgc gctggtctgt 180 gtggaaggag gaaggcaggg agaggtagaa ggggtggagg agtcaggagg aataggccgc 240 agcagccctg gaaatgatca ggaaggcagg cagtgggtgc agggctgcag gagggccggg 300 agggctaatc ttcaacttgt ccatgccagc agcccctttt tttccagacc aagggctgtg 360 aacccgcctg gggatgaggc ctggtcttgt ggaactgaac ttagctcgac ggggctgacc 420 gctctggccc agcctggtgg agcgtccagg tctgggtgcg aagccggccc ctgggcggag 480 gtgaggggtg gtctgaggag tgatgtggag ttaaggcgcc atcctcaccg gtgactggtg 540 cggcacctag catgtttgac aggcggggac tgcgaggcac gctgctcggg tgttggggac 600 aacattgacc aacgctttat tttccaggtg gcagtgctcc ttttggactt ttctctaggt 660 ttggcgctaa actcttcttg tgagctcact ccaccccttc ttcctccctt taacttatcc 720 attcacttaa aacattagct ggtcatctgg taagcccggg acagtaagcc gagtggctgt 780 tggagtcggt attgttggta atggtggagg aagagaggcc ttcccgctga ggctggggtg 840 gggcggatcg gtgttgcttg cctgcagaga gggtggggag tgaatgtgca cccttgggtg 900 ggcctgcagc catccagctg aaagttacaa aaatgcttca tggaccgtgg tttgttacta 960 tagtgttcct catggcgagc agatggaacc gggagacatg gagtccctgg ccagtgtgag 1020 tcctagcatt gcaggagggg agaccctgga ggagagagcc cgcctcaatt gatgcctgca 1080 gattgaattt ccagaggctt aggaggagga agttctccaa tgttctgttt ccaggccttg 1140 ctcaggaagc cctgtattca ggaggctacc atttaaagtt tgcagatgag cttatggggg 1200 gcaatcttaa aaagtccaca gcagatgcat ccggctcgag gggccatcag ctttgaataa 1260 atgcttgttc cagagcccat gaatgccagc aggcacccct cctttcctgg ggtaaaggtt 1320 ttcagatgct gcatcttcta aattgagcct ccggtcatac tagttttgtg cttggaacct 1380 tgcttcaaga agatccctaa gctgtagaac attttaacgt tgatgccaca acgcagattg 1440 atgccttgta gatggagctt gcagatggag ccccgtgacc tctcacctac ccacctgttt 1500 gcctgccttc ttgtgcgttt ctcggagaag ttcttagcct gatgaaataa cttggggcgt 1560 tgaagagctg tttaatttta aatgccttag actggggata tattagagga agcagattgt 1620 caaattaagg gtgtcattgt gttgtgctaa acgctgggag ggtacaagtt ggtcattcct 1680 aaatctgtgt gtgagaaatg gcaggtctag tttgggcatt gtgattgcat tgcagattac 1740 taggagaagg gaatggtggg tacaccggta gtgctctttt gttcttgctt cgttttttta 1800 aacttgaact ttacttcgtt agatttcata atactttctt ggcattctag taagaggacc 1860 ctgaggtggg agttgtgggg gacggggaga aggggacagc ttggcaccgg tcccgtgggc 1920 gttgcagtgt gggggatggg ggtatgcagc ttggcactgg tactgggagg gatgagggtg 1980 aagaagggga gagggttggt tagagataca gtgtgggtgg tgggggtggt aggaaatgca 2040 ggttgaaggg aattctctgg ggctttgggg aatttagtgc gtgggtgagc caagaaaata 2100 ctaattaata atagtaagtt gttagtgttg gttaagttgt tgcttggaag tgagaagttg 2160 cttagaaact ttccaaagtg cttagaactt taagtgcaaa cagacaaact aacaaacaaa 2220 aattgttttg ctttgctaca aggtggggaa gactgaagaa gtgttaactg aaaacaggtg 2280 acacagagtc accagttttc cgagaaccaa agggaggggt gtgtgatgcc atctcacagg 2340 caggggaaat gtctttacca gcttcctcct ggtggccaag acagcctgtt tcagagggtt 2400 gttttgtttg gggtgtgggt gttatcaagt gaattagtca cttgaaagat gggcgtcaga 2460 cttgcatacg cagcagatca gcatccttcg ctgcccctta gcaacttagg tggttgattt 2520 gaaactgtga aggtgtgatt ttttcaggag ctggaagtct tagaaaagcc ttgtaaatgc 2580 ctatattgtg ggcttttaac gtatttaagg gaccacttaa gacgagatta gatgggctct 2640 tctggatttg ttcctcattt gtcacaggtg tcttgtgatt gaaaatcatg agcgaagtga 2700 aattgcattg aatttcaagg gaatttagta tgtaaatcgt gccttagaaa cacatctgtt 2760 gtcttttctg tgtttggtcg atattaataa tggcaaaatt tttgcctatc tagtatcttc 2820 aaattgtagt ctttgtaaca accaaataac cttttgtggt cactgtaaaa ttaatatttg 2880 gtagacagaa tccatgtacc tttgctaagg ttagaatgaa taatttattg tatttttaat 2940 ttgaatgttt gtgcttttta aatgagccaa gactagaggg gaaactatca cctaaaatca 3000 gtttggaaaa caagacctaa aaagggaagg ggatggggat tgtggggaga gagtgggcga 3060 ggtgccttta ctacatgtgt gatctgaaaa ccctgcttgg ttctgagctg cgtctattga 3120 attggtaaag taataccaat ggctttttat catttccttc ttccctttaa gtttcacttg 3180 aaattttaaa aatcatggtt atttttatcg ttgggatctt tctgtcttct gggttccatt 3240 ttttaaatgt ttaaaaatat gttgacatgg tagttcagtt cttaaccaat gacttgggga 3300 tgatgcaaac aattactgtc gttgggattt agagtgtatt agtcacgcat gtatggggaa 3360 gtagtctcgg gtatgctgtt gtgaaattga aactgtaaaa gtagatggtt gaaagtactg 3420 gtatgttgct ctgtatggta agaactaatt ctgttacgtc atgtacataa ttactaatca 3480 cttttcttcc cctttacagc acaaataaag tttgagttct aaactcatta gaattgttgt 3540 attgctatgt tacatttctc gacccctatc acattgcctt cataacgact ttggatgtat 3600 cttcatattg tagatttagg tctagatttg ctagctccaa gtaattaagg ccatgtagga 3660 gagcatggta accacagata gaactggtat tatcccaagt ggtctgcaga ctgctgagtg 3720 gggatgggat ctgctctctg ttgagagttg gtaatcattg gtttgaaatg tgatgaaacc 3780 actcaagcca atgaaggtgg gtgtgtaggt ggggagtact ttgccataat attttaaaac 3840 attacctggt tagagttcta agtggtactt atttttgttt ggttagggga aagcctgaat 3900 aaaaacagaa atggacacat aatatgcata ttccatagtc tttgggaggc tggaatgtgc 3960 ctgggatttg ggtctaagtg tatgcgtaat tcttacctca ctaaagaatt tgccttgttt 4020 ttttcctttt ggtgagtgac taaaacgtct gggcttccct gtgtgcgtgc tacagtaagc 4080 aagcagaggc tgtgcaaagg tgtgagcagg atcacgtgga atctggagga tacatcttgg 4140 cttgcaaact gcctctgtct cctgggtggg actgttctgt ccttgcactg ctgttctgtg 4200 ttacctcttg gggtgtaagg ttttgcttac aggagacaaa ctttgggcgt agaatggaag 4260 ccactgccag cctctgtgct gagaaggaag gtgcttgttt caaagggagc agcaagggag 4320 gcttgttcta ctcacctggg cctgtttgcc tgagaagggg agataagggc tgaactggga 4380 ctagccaggg ggaccaacac aaatggtggg ggatcatgac ctgaaggatt ctttccttcc 4440 catgagctgc agggctggtt gccgtccttg caactgtgtc ttatttgcct gtgccgttat 4500 atcttggtga cccctccacg tgtacactac tgacaaacgg gtggagtgct ggggagaagt 4560 cactgtgccg cccacctagt aaaccttctg tctgtgctca tggcatctcc aagatggggc 4620 actgctgtgt gcagaatcca gggtcctctt tctgcttgca actcctttcc ctggatgccc 4680 cagaaacaat ccaggcctcc tttcctatct tacccctttg ctttgctttt taccccagca 4740 cctctataac cgccttctct tcttttcaga actccttgtt tctcatcctg ttttttatga 4800 ttacaaaact cttgcttcca ccctggaaga taactgctat agatgcctgt atgtaaatgg 4860 tgctgtctcc agcaactggc atgctgaaga agaattgatt cacggggtat aaatgttggg 4920 gattggaagt ggggatgaaa tggcacttgt tgatacagga gcagagaggt gaggccgact 4980 gctgaagaca gctcgccacc ctccttgcct ccactccaat ccaggggctg gggccacatt 5040 ctttgccttc atttatcctc agatcaggtg agatcgacag gaggtgttga tggcagtgcc 5100 agcaattatt gctaatccgt ttgcatcctt atgcatagat ctgaattcag actttgtgaa 5160 tttccagagg tgtgggtaat ataatagaat tcagtgagtg ggcatggctg atcttgtgca 5220 aattaaaagt tatggggcat aagaatagca aaagttgaac ttcttttaaa aaggaaagta 5280 ccctgagagc cagtattggt tgaggctctt cagtatgccc aggttggcag cactgagaac 5340 cgcaggaacg gcctgttgtt acaaaaagga gattgactca gctgcccttg gtgcatctga 5400 ctgactatga ctgctgagag attccaagga cccttaatgc cagggctaac ctctccatgt 5460 gcagtgagac ctctggagga agtgtcatcc tctggctttg tgtggtactc attatggtgc 5520 agtgcgggca tgaaatgaag acacccaaat aggcttacag atacgatatg ttttaaatgt 5580 tcgtatttaa caaaaacata ctgacactgt ttggaaatgg caacaggaag atagcaaaat 5640 gaatactaac attacgaaaa gatgaacagg tacatgttcc aaggcaggtg gctgtgaact 5700 tcctctgagt gaaggcatcc cctccagcac ctttcagcct gctagttagg acgacccgcc 5760 gccaccctcc aggacctcca gccctgcact gcctttcctc tcttttaaat aattcttcat 5820 tgagttctaa tatgtaaaaa aaaaaagttt actgtaaagt ttgcaaataa ggaaattttt 5880 tttaaaagtc ctcagtaatc ttaccagtaa caattgttat gggcacattt gcttttggaa 5940 gatttctttt gtatgcatgg gataagtaca tttttaaaca aaaatgggat tatgccataa 6000 attctatttt gtgactttaa tatatagtga acaccttttt taatgatgac aggatgttcc 6060 cttgcatggc tgtatcaatt taaacaatct tgtttcaatg ggcatacagg gtattttcta 6120 gttttttttt cctcttagaa aataatactt gcgatgactt tccttgtagc tcagactttt 6180 tcacgtctgt tgttatctct ttgggaatgc tgaatacata catttcgaga aggaaatgac 6240 tgttaaactc ttaagacttc aggttcatat tgctaaactg cccagcaggg agggattttt 6300 tcaattagtg ttctcactgg tgaggcaaac ctgatgcctt cccctcttcc tcagaaccgg 6360 ctttatcaca ttgaaaacct ttgctcctcc gacggatcga gtctgctttc cctgtggatg 6420 tgagcattgc tttgtctgct ggtgactgaa catctctacc atgtgtcaat tggccatttg 6480 tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnattttct aattcctagt 6540 catttttcta ttgattgttt tgcaaaagcc atttacatct taaggatatt gataatcttt 6600 tgtnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtgt 6660 tttcaggtag ataaaagtta aacgattttc ttaggttagt ttatcactgt ggtttctgaa 6720 cttgttatgt gtagatcttt tccaccccaa gagtacataa atattaatcc atactttctt 6780 atggaacttg tatggtttcg ttttttacat ttaaaccttc ttccccgtgg tgtgtgttgt 6840 ggaatctgtg tttgtgtgag gaggggcatg gtgctctcag aacccacctc ctgtggccag 6900 agagccctgt cctgtgaggg tggttatcac agtggcaggg ttcaattcag aagaccttga 6960 gggcaggctg atgtttcctg aatgggcccc tggttgttgc ttgtccctga ctctccattt 7020 ccccatctga gtggatttgg acctaatagg gcactggagc tggttcgaat cctgactgga 7080 ctacttggca actttatgtc tgggagcaag ttacttaacc tccccaagct gtgtctgtga 7140 aatgcgggta aatgaatgta gatgtttggc agcagctact ccttgtggag ctctcacagt 7200 gaactctcct gcctctgccc tccttccccg cctcccctgg tgcctagcgt caggtctagc 7260 cacttcctcc tgggcccctc tcccttttct gtggctggct gcctgcccgc ctggcgctgg 7320 acctttcatg taacgggaat cagcatgtat attctggtct ggtctgtttc tacacttaat 7380 tttgtttcca gtagtatttc cctgtaccgg cagagttcac aaacacattt gaagaggctt 7440 tttctcagga ttcttaacct tcccaaagga agtcccatgg atgggtttct agaagtctat 7500 aaatgctctg aaattgtatt tttctgtgga aagcataact ttcatctgct tgttcgtgct 7560 caaaaaagat catgaatgaa tgattgccat gatgtttatg ccattgtgct tatactaaag 7620 gatatgtagc ccatctcttg agctgttaaa ctgttttgac tactttaaat cgtgcagctg 7680 tgagcatctc tgtaaattta gtgtacacat gtatcccctg gagtggcatt gcctcggcag 7740 tgagcactta tggttttata actctcttca cagactcaaa tgactccaga aagctacact 7800 tcctgttgtg agtatatgat atccatttcc ctacatagcc actaacatca ggtttttaca 7860 attttattta tttcttgcta ctttaagaaa tttttgtggt gaaatacata taatagaagt 7920 tgactatctg aatcattttt aagtatacat tcagtagtg 7959 <210> 356 <211> 6255 <212> DNA <213> Homo sapiens <400> 356 gagcggagat ctcggggctc ggagccggcc gccgctccgc tccgatcgct gtggggcttg 60 gttttttggc gggtgggggg gcgggggggc tcagatatgg aggcaaatgg gagccaaggc 120 acctcgggca gcgccaacga ctcccagcac gaccccggta aaatgtttat cggtggactg 180 agctggcaga cctcaccaga tagccttaga gactatttta gcaaatttgg agaaattaga 240 gaatgtatgg tcatgagaga tcccactacg aaacgctcca gaggcttcgg tttcgtcacg 300 ttcgcagacc cagcaagtgt agataaagta ttaggtcagc cccaccatga gttagattcc 360 aagacgattg accccaaagt tgcatttcct cgtcgagcgc aacccaagat ggtcatgaga 420 acaaagaaaa tatttgtagg cgggttatct gcgaacacag tagtggaaga tgtaaagcaa 480 tatttcgagc agtttggcaa ggtggaagat gcaatgctga tgtttgataa aactaccaac 540 aggcacagag ggtttggctt tgtcactttt gagaatgaag atgttgtgga gaaagtctgt 600 gagattcatt tccatgaaat caataataaa atggtagaat gtaagaaagc tcagccgaaa 660 gaagtcatgt tcccacctgg gacaagaggc cgggcccggg gactgcctta caccatggac 720 gcgttcatgc ttggcatggg gatgctggga tatcccaact tcgtggcgac ctatggccgt 780 ggctaccccg gatttgctcc aagctatggc tatcagttcc caggcttccc agcagcggct 840 tatggaccag tggcagcagc ggcggtggcg gcagcaagag gatcaggctc caacccggcg 900 cggcccggag gcttcccggg ggccaacagc ccaggacctg tcgccgatct ctacggccct 960 gccagccagg actccggagt ggggaattac ataagtgcgg ccagcccaca gccgggctcg 1020 ggcttcggcc acggcatagc tggacctttg attgcaacgg cctttacaaa tggataccat 1080 tgagcaggtg ctttcgttgc catctcactc tgagagcata cctggatgtc caggcaagac 1140 tgggcgaagt ttctgagtgg ccctttgttt aggtgatgtc ctcagacctg gacccccacc 1200 agcctcactc cccatcccaa ccagagatgg ctcacttcgg atcgagggtt gactacatct 1260 catcatctca cgaatctgct gtaatataag acaacagctt ttaaatgtgt atataaccca 1320 tgatttcggt tttgttttgt tttgtttttc ttgatggttt ccctctccct ccctctcttc 1380 ccattctcct tttaaatctc tttgaatcac atttggtagt gattttgact tagtccagta 1440 gtcacatagc tttaatatct agttcaaagc taaccatagt ataattgtta tattaaggag 1500 ttattttttc ttaaaacatt ttttttttgc ttgttttggt tctgttctca cttttaaagg 1560 atgctgagat ggtaatatga ctctccctat tttggtacca attctgagac tgtatgaatt 1620 ttcaggtgga actttagcac acactgaagc aaagttgtga agtgcagggc gggaggtggg 1680 cgtgagcttt ctattttgcg ttgtagaaga agtgagatgt agtaagctaa ttaacagact 1740 ttctagcagt tctttttgtg atgtctcttt gttaatctga gtctatctat tttcggcaat 1800 aaggtaagga cgacagtgtt ttgagtgtcc tccttttcta taagtgcttt ttttctgttg 1860 aaagaggtga tattataagg ttttttgaaa ttgtgaattc taaaaaagaa atgttgtaaa 1920 tacaattcca ttaactacat agaaactatt aagaaagaga gaatcaaaaa tatttttgtg 1980 agggagtcgg tcccaggcag tttgatgctc tgtggaagga ggcgggaagg gaacgttggc 2040 caagtcagtt actgagatga agatcgccca gctgccagga ccaccccagg acaagttaga 2100 gcactgttta gctcctttgt ctgtgtgata gacctaagaa ctgtattagt gttgtaccag 2160 cctattaacc tcttgtctgt gcacagcttc aaatgttacc gtctagttag atttttattt 2220 aaaatatgaa aaactgcttt tcccaagatg ttttttaaaa acaaagctac aattttaata 2280 tttaacatat ttaaagtttc aaagcacacc tgtttggctt gggtgggggt ggggtggggg 2340 ggacattctt tttcagtctt aatttttaaa tatttgatca ttttctattg tccaatcatt 2400 tcagcacctc caaaggtccc taggacactt tgcctctctt ctccccctgc cccccaccct 2460 gctcccacat ctgggggccc atgggccagg agtggataag cctgcattaa tacaaccttt 2520 ctccattcac tttctattta caaattagga aagcaacctt ttggtttata tatatttttt 2580 ttaatacctc agtgctgcaa gtatcaccag agaggctatg gaagaatttt tttttaattt 2640 attgtagatg taaacagaat tttaaaaata aaaagtataa acatcactgc actgtgactg 2700 gtgggaaaaa ctgacagttt cctctttgca catgtttaac atttggctgt tataatatat 2760 ggtcctcggt tggggaaaga tacttatgat gaaggatatt ttttaattta actttttttt 2820 aaatattggt aataggtcgg caacagcaac tatagaagta caactcaata gatggcatta 2880 aaacatattg tagtgtggat atatattttt tcttttttaa aatgtgatat tgacgtttta 2940 ttaatatttt ttaaattgtt acgtttataa atttggtact taaggcacag ccagtatgag 3000 acactgaatg cgacatttat tataaagagc tgctgcactc ctatttttat aaattttact 3060 aacaaagtag actaatgtag acattcacag acatggtagg gcaaaagcat cttcaaacta 3120 aagactccaa aatgctaact cagaaagaaa gaaaaaaccc gttttcaatt ctaatgaaac 3180 agcaacaaca ttttttttaa ttaaaaaaaa aatcatgttc tttgtttttc taataaaatg 3240 ttaggttgtt tggtgaggtt tttttgttgt ttttttcctt tctttgtttc ttttcttttc 3300 ccccaaacaa ccagattaaa cgctgagcgc ttttaaaata tcaaaacttg ttcaagtcat 3360 aaaacaacaa aacataagtt ttatttaaaa aanaaaaaag aaagaaaaaa tagtaaattc 3420 ccagaaattc agtgtttaga cgagggaatt taattcctat tttgtccatg ttggtgatgt 3480 actgtacttc ccttcctttt ctctgcatcc cccatcacct catagaagac tctttgttga 3540 tcattgtatg ttaataatgt ataaaatggc tatcttgtaa gcgtgctgtc ctggtactag 3600 tgtagcgact ttttttctcc tctttcttct agtacatatt gataggtata acataattaa 3660 ggtttaaaaa aaattagaca tagttattca gatttaggac cagtaaggat agaactttct 3720 cttatttatg aaaaaaaatg ctaataattt tggggcagtt ttttccttta attatttttt 3780 tcaatttcaa gtttaatttt attttagctg atctgatgtg gtttcaacta acccaaggtc 3840 tcaccatgtt aaaatgccgg cggactctac ggcgttttgt agatcccccc ccccccaccc 3900 actgtgaagg ggtgccatac taccttaaat gctaatgcta gatatgcaaa actggatttt 3960 tttaatttat tttttaaaag agggaggcat ggtatattaa aatgatttta ctaagagaaa 4020 aaatattttt ttaagaatgc tcagaagaaa ttgataatct gtgtgaatat gttttagatg 4080 tttatatacc ttttgaagag acccagtagc ccatagcaca aatcttgtgg aaatccgata 4140 tgttttaatg tggctaccta ggtttaaggt tcacgttagt ccccccattc catctagaag 4200 tccattttga aagatttttg taaattcttt taacactgat gtttcagcct cgtctttgtt 4260 tcagttaagc tcaatggcga acatgggaac cacctttcgc cttccctggg ggagaaaccc 4320 tcttggctga tggcttttcc ccggaattat caaacagcca ccgggtgact ttctggcttc 4380 cagatccatc tgcctgagac ccccgaactc ctctcctccc aagcagaggc gagtgagtgg 4440 cattagctcc cggacccatt cccggtccta gctgggcatg gggctgacgg agatgaccaa 4500 gccttggtct gctctctagc agcttccaca gacttggctc gtggccttcc ttatatccac 4560 tgggaacaaa cagcctcgcg ctctatacca aacagcctcg cgctctatcc cagtcgccca 4620 ttagcttgat tcaaacaaag ccccagcagg cctttgcgtt tttatccttc ataaccttca 4680 tcttaatttg aacttgtagc ttggacttta aggtagcatg gctctattgc tgtcaattta 4740 ctgtttcact gcacagcaat cacagccagt gaatgttaca cacatcttgc tagactagta 4800 taaaaatcat tgggtaattg ttggttctaa tgacctgaaa ggtgttcagt ttttgttctt 4860 ggttttgttt tgtttttgat ttcttggggg tgggttttgc ttgttgttcc ttttcatttg 4920 ggggtttttg gggaaaaaat ttatttttgg ttccaaatag aaaaacaaaa cctattttga 4980 tctttagtgc aaacgagggc tagggactta gcctcctcca ccacctccac actgcttcat 5040 tctgccattc actcactgca gcatattcaa gaataaagca atatcgttta ctacattttt 5100 tattgaaggt cagccatgct ttctgtatta tattgcatat gaaattgttt acaaaagaaa 5160 cactaactca tacttctctt tattggttgc aagtggcacg caggaacaga gggagagtgg 5220 ggggctggtg ggggagggga gattttttat tatgagtctt gaatgtgctt cgcaagccag 5280 gctatcttcc aaggaaggca gacagtggga gagcagaggg actgactgca ggcaagcaca 5340 ttgaagaaag acactggcgg gtttccccac cctcacccca aagcagaaaa ctagcagacg 5400 tcagctcagc cccgtcctgg gcacagacac tacacaagga gacgctggaa gttaagcaat 5460 actttaatac tgtaatatgt ttgttttctt tttctttctt ttttttctac caaaaaaaag 5520 taagtaaact aaaacacaaa aacatataaa taaaatccat ccctcttgtc ggggacctgc 5580 aggggggcaa ccttaatcca aacacctggc tatcaaataa tcagaatgta ttgtctcaga 5640 caggatttca gttccgggag gcaggggcat gatgggggag ggggccggag gctgagagac 5700 aaaagttcca gagcctccct cgaaggttct ctactactgt attctgtaca taatgtacca 5760 tcccatgtgg aatctgtgag tgtcctctta agtagcgtgg gctagccaat ctgccgttca 5820 tggtgtattg taaactccga attccatatg taataggatg caagtctaag cgtttcatgt 5880 ggacataaat gtatctaaat aaaactttcc ctagcactgt ggctgacctc acccttactt 5940 ttatacttta gtatgaaact gatgagaact ttggtagtga gtattttttt tatatatata 6000 catatatatg tactatctat atatatatct caagcatctt tcaggtcttt gtgtgtggct 6060 ttcttaaagc cctgttgtaa aaaattacta tgtggatggc agtctctcac atcacagatg 6120 tggaaagtat aattttatat ttgtattttc aaataaataa gtttgtgaaa ggtttccatc 6180 ctctactgtg gtccagaaat caatgtgttt gtctgacaaa aaaaaaatta aaataaaata 6240 aactgttttg aacag 6255 <210> 357 <211> 5786 <212> DNA <213> Homo sapiens <400> 357 ggcacccgag aacagtggtg cactgtttcc gctgccctcg tttgtctaat tggcccagac 60 gctccaccag cgcgaanttc ccgggagctc ctcgctggcc acccccgcgg cccgcagccc 120 ggcagaggcg ggaaagcagc gcgcctgcgc cgtgggaacc ggggctggag gcgaaaagcg 180 gggagcggag gggggccgct ggagccgagt agcgtacaga gcggcgtgtg acgcggggac 240 gccgcgtgct cccaacgtcg ccccggtttg acgcacacgg caccaaactg tttgatttaa 300 ttttggatga gatcgttctt gcagcaagat gttaataaga caaaatctag actaaatgtg 360 ttaaatgggc ttgccaacaa tatggatgat ttgaagataa acaccgatat tactggtgct 420 aaagaagaac tcctagatga caacaatttt atctcagaca aagagagcgg agttcataag 480 ccaaaagatt gtcaaacatc atttcagaaa aataatacgt tgactctgcc tgaagaactg 540 tcaaaggaca aatctgaaaa cgccttaagt ggaggccagt ctagtctatt tatacatgct 600 ggtgctccta ctgtttctag tgaaaacttt atcttgccta aaggagctgc tgttaatgga 660 ccagtttcac actcctcctt aactaagact tccaatatga ataaaggcag tgtttcatta 720 accactggac agcctgtgga tcagccaaca acagaatctt gttcaacttt gaaggtagca 780 gctgatcttc agctgtctac accacagaaa gcaagtcaac accaagtttt atttttgtta 840 tcagatgtag cacatgctaa gaatcccacc cattccaata aaaaactacc tacctctgct 900 tcagttggtt gtgacattca gaattcagta gggagtaata taaagtcaga tggcacttta 960 ataaatcaag tagaggtggg tgaggatggt gaagatttat tggtgaaaga tgattgtgtc 1020 aatacagtaa cgggaatttc ctcaggtaca gatggattta ggtcagaaaa tgatacaaac 1080 tgggatcccc aaaaagagtt cattcaattt cttatgacta atgaggaaac agtagataaa 1140 gctccacctc attctaaaat aggtctagaa aaaaaaagaa agcgaaaaat ggatgtaagc 1200 aagataactc gttataccga ggattgcttt agtgattcta attgtgtacc caataaatca 1260 aaaatgcaag aagtagactt tctagaacaa aatgaagagc tacaagcagt agactcacag 1320 aaatatgcat tatcaaaagt gaagcctgaa tcaactgatg aagacttaga atctgtggat 1380 gccttccaac atctaattta taacccagat aagtgtggag aagagagttc acctgttcat 1440 actagcactt ttctttcaaa taccttaaaa aagaaatgtg aagagagtga ttctgagtca 1500 cctgctactt tcagtaccga agagccatca ttctacccct gtacaaagtg caatgtgaat 1560 tttagggaga agaagcacct ccacaggcat atgatgtatc atttagatgg gaatagtcac 1620 tttcgccatc ttaatgtccc aaggccatat gcttgtagag aatgtggacg gacatttcga 1680 gatcgcaatt cacttctaaa acatatgatt attcaccagg agagaagaca gaagttgatg 1740 gaggaaattc gtgaattgaa agaacttcag gatgaaggaa gaagtgcacg attacagtgt 1800 cctcagtgtg tgtttggtac caattgccct aaaacatttg tgcaacatgc taaaacccat 1860 gaaaaagata aaaggtacta ctgctgtgaa gagtgtaact tcatggcagt gacagaaaat 1920 gaattggaat gccatcgagg cattgcacat ggggcagtgg taaaatgccc tatggtcact 1980 tctgatattg cccagagaaa aacacaaaaa aagactttca tgaaagactc tgtagtagga 2040 tcatccaaaa aatcagctac ctacatatgt aagatgtgtc cttttactac ttcagccaaa 2100 agtgttttaa aaaagcacac ggagtacttg cattcatcat catgtgttga ttcatttggt 2160 agtcctcttg gacttgataa aagaaaaaat gacatccttg aagaacctgt agatagtgat 2220 agcactaaaa cattaactaa acaacagtca accacatttc caaagaactc tgctttaaaa 2280 caagatgtga agcgaacatt tggatcaacc tcacaatcaa gtagtttttc aaaaattcat 2340 aagcggccac acagaataca gaaagctcgg aaaagcattg cccaatcagg tgtaaacatg 2400 tgcaatcaaa acagctctcc tcataagaat gttacaatta aaagcagcgt tgaccaaaaa 2460 cctaagtatt tccatcaagc agcaaaagaa aagtctaatg ccaaggcaaa tagccactat 2520 ttgtatagac acaaatatga aaactatagg atgatcaaaa aatcaggtga atcatatcct 2580 gtgcatttca aaaaagaaga agctagttca ttaaattctt tacacctgtt ttcatcatca 2640 agtaattctc acaacaattt tatttcagac cctcataagc ctgacgccaa aaggcctgaa 2700 agcttcaaag atcacagacg tgtagctgta aagagagtaa ttaaggaatc taagaaggaa 2760 agttctgttg gaggggaaga cttggatagc tatccagatt ttttgcataa aatgactgtt 2820 gtcgttttgc aaaaacttaa ttctgctgaa aagaaagata gttatgaaac agaagatgaa 2880 agttcctggg ataatgttga gttaggagac tacactacac aggccataga agatgaaacc 2940 tatagtgata ttaatcaaga gcatgtaaat ttattccctt tatttaagag caaagtggaa 3000 ggtcaggagc ctggagaaaa tgctactctt agttatgacc aaaacgatgg cttttatttt 3060 gaatactatg aagatactgg aagtaacaac tttttgcatg agatacatga tcctcagcat 3120 ttagaaactg cagatgcttc attgtcaaag catagttctg tttttcattg gactgatttg 3180 tctcttgaga agaaatcgtg tccttactgc ccagcaacat ttgaaacagg tgttgggtta 3240 tcaaatcatg tcagggggca tcttcacaga gcaggattaa gctatgaagc ccgtcatgtt 3300 gtatcaccag aacaaatagc cacaagtgac aaaatgcagc atttcaaaag aactggcaca 3360 ggaacacctg ttaaacgagt tagaaaagct atagagaagt ctgaaaccac ttctgaacac 3420 acttgtcagc tctgtggtgg ttggtttgat actaaaattg gattatcaaa tcatgttaga 3480 ggccacttga aaagacttgg aaagacgaaa tgggatgctc acaaatctcc aatctgtgtt 3540 ctgaatgaga tgatgcaaaa tgaagaaaaa tatgaaaaaa tcttaaaggc attgaacagt 3600 cgtcgtatta ttcccagacc atttgtagct caaaaacttg catcaagtga tgactttata 3660 tctcaaaatg ttatacctct tgaagcatac cgtaatggcc taaagactga agctctgtca 3720 gtgtctgcat cagaagaaga agggctgaat ttcttaaatg aatatgatga aacaaaacca 3780 gaactgccca gtgggaaaaa gaatcagtct cttacactca tagaacttct taaaaataaa 3840 aggatgggag aagaaaggaa ttctgctatt tctcctcaaa agatccataa tcagacagca 3900 agaaagagat tcgttcagaa atgcgttctt ccattaaatg aggatagtcc gttgatgtat 3960 cagccacaaa aaatggactt gactatgcac tcagccttag attgtaagca aaagaaatca 4020 aggtcaagat ctggaagcaa gaagaaaatg ctaacattac ctcatggtgc tgacgaggtt 4080 tacattctcc gatgcaggtt ttgtggccta gtctttcgag gacccttgtc tgttcaggaa 4140 gactggatta agcacttaca acgacatatt gtaaacgcta atcttccacg gactggagct 4200 ggcatggtgg aagtcacgtc actacttaaa aagcctgcct ccattacaga aacttcattt 4260 tctctactaa tggccgaagc agcttcatag aaccaggaaa ccttttaaat agccagtttg 4320 aattggatgt aaatttgaaa ttcttttttt ttaagccaca ttaaattatc tgtttataaa 4380 tactaaagca ggaaaatggg gggaaagtga attacagtga catcagagca aattgaatac 4440 ttaaaacagt aagtagtcta tatattttat atagggtgga agatgtgttt ttaaggttta 4500 tgaagttttg ttggttaact gtgttcactc agtaaaagag cagtacatgt aagcagccat 4560 taataaactg ttgcacatgg atacttatag acagacttat tggacaatta tgttttttgc 4620 agtgttacca gaatcaaggc tctgtttatt ccccacaaga cttgcataga aaaataagat 4680 attatatttt gtttgtatgt atttagtgtt ttgtataata ccaagaaccg ctgactaaat 4740 ttactcaaat tagggcatta aatatcatgt acttcatagt ttgagactgt tcactcaaat 4800 agggcagagt actattctat ctagatgtgt aagtgttttt tttaaaatca catggaacgg 4860 ttttttttat actaaaaagt ggagggagat ttgtttaaac aagtatttct aaaagaaata 4920 tgtacatagt tctggaaatt atttgtggta aggaaatatt ctttactcca gttgcatttc 4980 tcagacaata aagtggtgca tccatgctac ctcctacttt gtcaacaaag atgctattta 5040 ccctttacat ttttgtatca taatagattt taaaaatcta atgttcttta ttgcaagaca 5100 ttcttttgtt aacaggtttg tttcttttta atgttttacc taaaatttga catgcttaca 5160 ggacaggttt gcctcttact ttatttaaca ttgtagaaat gtaattaata aacaatgctc 5220 actacacagt ttagaataga cgttctcatt tatattatct tccaaatttg atcagttagc 5280 aaaacttaat acaccaatta aaatatttct acatatgaga atgtttacaa tttaaatttt 5340 agaacttgtt ttggatgtga ttatatgtac gaaaatcgtg taacactatg ctcatgctaa 5400 gaaccgacat aacagaatta ctgaaataaa tgtgctgtga ggaatggaaa atatggtgca 5460 ggtgtcttgg tcatgataaa ttgtgattct ttttaaaaat tttttccaaa aacaattagg 5520 tattttaatc tgaaatcaga ttcctttaca aacaacaagt ttttgtatgc aagcaccatt 5580 ttatttcatg tagtatggct aatactatag ttgaaccaag gatatgcatt gattctttgc 5640 ttcgtatgta aataaagtta aaaacagtta aaataaggag tattttggta gagtatatac 5700 atacctcact gccagtgaaa ttgctttcct atggtatatc tccttaccag aaaaatctct 5760 aaataaaaaa aggtttaaag aaaatt 5786 <210> 358 <211> 2360 <212> DNA <213> Homo sapiens <400> 358 ggtgatgagt ttctaatccc aaatatattt gcatttacca ggcttttgtg agtttaagaa 60 gttatctatc atatctnnnn nnnnnnnnnn nnnnnnnnnt gcttgtttct atcaagaatg 120 actcctttat aaactgggga gtatctttaa gagtggtttc aaccctgact gtatagtatc 180 atctgttgag gagcttaaaa aaaatatgta ggcccagccc acactagact ggcattggta 240 cctggtatca gtatttttta aaaacttccc ataggattct aatgtacagc caagattgag 300 gaccatttgt ctgtcatctg ggattatgct taataaatta atactgtttt ttaaattaat 360 tagatttcac ttctaagtca ttatcagtaa atttactcag tatctaactg acaagaattt 420 ctagcatata tttcttgatt agtgcatgta aaattctaaa agaatttcta tagtattttc 480 caggcaataa gacaactagt gccccaaatt taccaaatgc atgagtctaa gcctgtgcta 540 tatataaata tactcaaagc caagtttaca tctgtgtaca caagtgtgca tgcatatgta 600 caattaaaga ctatagttgt aacagtcatg agcttgtgtt ttgattttac tcctattcct 660 gtattgtatt aagtgtacta tcatgttctt gaggcatatc tccaggagat atgtttattt 720 cttttccagg aaaagtggga catatataag tagggtaaac gctagagcta gatactcctt 780 taatctctat tacgtcagat ctctggctcc cttttacaac caggcaatct tcaattatag 840 gtggctaata gggaagaaaa tcatcggcag agcaacagct tcatgtaatt tcagagtaga 900 aaaatgaatt ttaatcttct gaaaggtaat attagaatta gctggattgc tacacttagg 960 aatcataggt tccaaataaa tatcagtaca tacggaaatc agataatggg acagattatt 1020 tgaaattagg gctgcctaga aatctggaat gtgagatcac cctccttctg accaaatatg 1080 cttgaataaa cttaatattc caaattatgt gagggattgc ctattgtgca aaaaaaaaaa 1140 aacgaaatct gaatttaaaa aaaattacca cagtctagta ttattttagt ctcttggatg 1200 ttataacgtt atctgtccca tctgttgtta atatgagaca ctgtacaaac aaacaactat 1260 tttgatttag aatcagtata gatcacctag ctttttgtct caattttcct actttaatgc 1320 tcttggggct ttcgcttttg attttcagtt ttttccttaa aataattaat attgttgaaa 1380 ttagactttc taaatttaaa tttatcagaa tttcctatgt aaaatgagtc taggcaccaa 1440 atgtttaatg actttaaaaa aaatgtttat gactataaaa ggaaaaaccc tgtatcaatt 1500 tcaagcttgt tttatatcca aagtgctagt tattttgtga tgagaatata tgccccaaga 1560 acatttttga aagacatata gttagtaact tttttatttt tcaacttaca taaaataaac 1620 ttattacttg tttcacaagt ttgagttttc aaaataatat ttactaaatg gcatatttat 1680 gtacatccag ctgaactttt tgcttgaatt gggtttctac attttaaaaa gtctttcagt 1740 aatatacgat tttttatgaa tgtttttcat ttaataatta tgaaatcaag taaagctaaa 1800 aggaatctta aattcccaat atgatatcat ttttttcttc tcaaaagtaa gtagtaatga 1860 ggttttacta taaactgtta cagcattctt taaaacgaca atgacaataa cattttcatc 1920 ataatacaaa tttttgcaga tgagttgaat atatcaatga aagaaaaaaa tctacttttt 1980 cttgtttcct ttcacaggca atgataccgt ctttatccaa gttactctgc cccatggccc 2040 aagttagtat atttggttta agactcataa ttcttgcttt ggctttaaaa atcaaaccaa 2100 gtgtaacctt tcctgctaaa actcttcttg ggtctggcag cattggtacc ttgcttgcaa 2160 catcctagaa gtgaggcctt cacttgtgct atctttagat cataagtgat ttgcttaaat 2220 ttatatattt ctcatgcttt ttataaaacc ttgtttctct cttaaaagaa catattaaat 2280 aagtggcttc cacatttaac catttctttt ttccaactat agagttctaa gtatatttta 2340 atgctcaact ttgaaaaaaa 2360 <210> 359 <211> 1548 <212> DNA <213> Homo sapiens <400> 359 ggactcgtgg tggccttgcc ggcccagttc tcacgaggaa ggggatggcc caaagtccca 60 gcaacccaag ctgcccctga gggtcggagt gggtggggcg gctgctctgg gcaggcagtg 120 accccatgct gtccccttgc cttggcagga gctggagctg gtggaggatg tgtggcgagg 180 ggaggcgcag gacctcctct cccagatcgc ccagctgcag gaggagaaca agcagctcat 240 gaccaacctc tcccacaagg atgtcagctt ctcagaggag gagttccaga agcatgaagg 300 catgtcagag cgggagcgac aggtgatgaa gaagctgaag gaggtggtgg acaaacaacg 360 cgacgagatc cgcgccaagg acagggagct gggcctgaaa aatgaggacg ttgaggcttt 420 acagcagcag cagacacggc tgatgaagat caaccatgac cttcggcacc gggtcacggt 480 ggtggaggcc caggggaaag ccctgatcga acagaaggtg gagctggagg cagacctgca 540 gaccaaggag caggagatgg gcagcctgcg agcagagctg gggaagttgc gagagaggct 600 gcagggggag cacagccaga atggggagga ggagcctgag acggagccgg tgggagagga 660 gagcatctcc gacgcagaga aggtggccat ggatctcaag gaccccaacc gcccccggtt 720 caccctgcag gagctgcggg acgtgctgca cgagaggaac gagctcaagt ccaaggtgtt 780 cttgctgcag gaggagctgg cttactataa gagtgaagaa atggaagagg aaaaccgaat 840 accccaaccc ccacccatcg cccacccgag gacgtccccc cagccggagt cgggcatcaa 900 gcgactgttt agcttcttct cccgagataa gaagcgcctg gccaacacac agagaaacgt 960 gcacatccag gagtcctttg gacagtgggc aaacacccac cgcgatgacg gttacacaga 1020 gcaaggacag gaagccctgc agcatctgtg accttggccc atctccaccc tccaacctgg 1080 actgcccgcc accagcgcct gcaaccgaac tgcagcccag gggtcattgc tgcctcaagc 1140 ctctcggtgc agatgcaccc tgaaaactga cccctcaaac agactgtctg atttgaggat 1200 ggacattgaa aaactgacgc caaactctaa agaaatgttt atttataccc agggctatca 1260 ctgtttctaa tagatgactc tgatcccgta ggatatatat ttaataatcc cacaaacgga 1320 ggccagactt ctgcgttaac ttcagtaaca caagcttctt taagccaaat acatcacttg 1380 ccactatcat tgctgtttga cttgctttgt ataaaatgct atgtgtagag gttttattat 1440 cacaggtgac atagttcagc aggaggcatg gaagggctag atcttcatta gttacattca 1500 tgaaattgtg atggtaacgt attatacaga atgtatccat caggcaga 1548 <210> 360 <211> 1133 <212> DNA <213> Homo sapiens <400> 360 gcaccccatt gttattgtta ttgttagcaa aataagactc catggtagaa aaactatgca 60 agtcataaaa tgtatcagca ttaactttta tcaacagata gggtgctatt aaatgtatca 120 ccaacatagt aaaatgacag aaaggaatat tacagtgtga aagcatttat ttatttgttt 180 gacaacagct acaattgaaa tacagcaatt ctgaaggtct ttaaatgggt tgcactttgc 240 cctgttaact cactatttcc tgattggcaa taattttact tggtaatgct ctgtattatg 300 gtaaaagcta acaataataa tttatcgagt atattctttg tagcaggcac agttatgagt 360 gctatgtgaa tacatttaat cttcacagca actttgaagt aggtactatt actgtgcata 420 ttttgaagat gggaaaactg aggcagacag tttgcctctg gagccctcac tcttaaactc 480 ttatgatata taccagaaac tgtgacatag cccaggtgcc aaatctggcc ctccacctgc 540 ttttgtaaat aaagttttat tggaatacac ccatgcccac tcatttacac attgtctata 600 gccatttcgg tgctatagct tcagggtgga gctagttgct acagagacca cgtggcccac 660 aaacccttaa aacacctact gtttggcact ttgcagaaaa agtttgctaa cccctgatgt 720 caactttaaa cttcacaaaa agactggagt ttaaagggaa agaaataata tcttataata 780 aaaatgcctt atgtttggta tttactgtgg atttgtacat atttatctta cttaattctc 840 atagcaatcc tgtgaagtaa gtagtctttt tatttccatt ttagaaatga agaatcagga 900 gttcagaggg attaaatgac ttacactcta ggctgaagag caaactccat gagtgtaggg 960 atcatgtgtc ttcatcatca tgtccctgtc acctaccacg atgctagcac agggtggaca 1020 ctcagaaaat acttgctaaa tgaatgacag ttacaaaggt cacccagcta gagaatccag 1080 gtcttctcct cttccagggt tctttctcct gactccacag ctgtctgaca gtt 1133 <210> 361 <211> 755 <212> DNA <213> Homo sapiens <400> 361 caagtagcag cctcaggtgt aggggggctt gagcctctcc tcactcctct ctgattggtc 60 caaatttgct cagtctgggc caatcagagt ctttctcctg ggatgcagag agattagccc 120 aggtggatga tgagggagtg gcaaaccgaa gtctatgcat aagcagagaa agccagtctt 180 tgaagggaaa gaggacagag cgtctgcctc aagaataaca agagagacag tgtcctttga 240 aagcagagaa ggaactcagc catgacattc ccattgcagt ccagatgaac tgggtagtcc 300 ataagatgtt gcaccttgtt caaccctgcg catcctttct ccagaccctt ggagaaatac 360 ctcccacccc gtgttgccac cgcctaggga aatccaaaat ccagctgtac aatgtctgta 420 catttccagg ggcttccatc ctcaagtctt ctctgctcct aggcttggtt ccttgagtcc 480 tgtacctcca tccaactgaa tatgaaactc agatgcttca ctggtttcca taacaacaga 540 ataaaacaat gccctatcct actcccacag gtcatttgag gagcaataca atgaggatca 600 caaaaagggt gtcattgatc tcttcacagc agacagctta aaaaccataa ccagtgacaa 660 tcgtctcctg gctcaccatg taactgtccc tccagcccca gaggactagc cccagccaca 720 gccctgcaaa gaccttgatt ttttttttaa ttgcc 755 <210> 362 <211> 622 <212> PRT <213> Homo sapiens <400> 362 Met Pro Pro Gln Leu Gln Asn Gly Leu Asn Leu Ser Ala Lys Val Val 1 5 10 15 Gln Gly Ser Leu Asp Ser Leu Pro Gln Ala Val Arg Glu Phe Leu Glu 20 25 30 Asn Asn Ala Glu Leu Cys Gln Pro Asp His Ile His Ile Cys Asp Gly 35 40 45 Ser Glu Glu Glu Asn Gly Arg Leu Leu Gly Gln Met Glu Glu Glu Gly 50 55 60 Ile Leu Arg Arg Leu Lys Lys Tyr Asp Asn Cys Trp Leu Ala Leu Thr 65 70 75 80 Asp Pro Arg Asp Val Ala Arg Ile Glu Ser Lys Thr Val Ile Val Thr 85 90 95 Gln Glu Gln Arg Asp Thr Val Pro Ile Pro Lys Thr Gly Leu Ser Gln 100 105 110 Leu Gly Arg Trp Met Ser Glu Glu Asp Phe Glu Lys Ala Phe Asn Ala 115 120 125 Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile Pro Phe 130 135 140 Ser Met Gly Pro Leu Gly Ser Pro Leu Ser Lys Ile Gly Ile Glu Leu 145 150 155 160 Thr Asp Ser Pro Tyr Val Val Ala Ser Met Arg Ile Met Thr Arg Met 165 170 175 Gly Thr Pro Val Leu Glu Ala Leu Gly Asp Gly Glu Phe Val Lys Cys 180 185 190 Leu His Ser Val Gly Cys Pro Leu Pro Leu Gln Lys Pro Leu Val Asn 195 200 205 Asn Trp Pro Cys Asn Pro Glu Leu Thr Leu Ile Ala His Leu Pro Asp 210 215 220 Arg Arg Glu Ile Ile Ser Phe Gly Ser Gly Tyr Gly Gly Asn Ser Leu 225 230 235 240 Leu Gly Lys Lys Cys Phe Ala Leu Arg Asn Ala Ser Arg Leu Ala Lys 245 250 255 Glu Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly Ile Thr Asn 260 265 270 Pro Glu Gly Glu Lys Lys Tyr Leu Ala Ala Ala Phe Pro Ser Ala Cys 275 280 285 Gly Lys Ser Asn Leu Ala Met Met Asn Pro Ser Leu Pro Gly Trp Lys 290 295 300 Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe Asp Ala Gln 305 310 315 320 Gly His Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe Gly Val Ala 325 330 335 Pro Gly Thr Ser Val Lys Thr Asn Pro Asn Ala Ile Lys Thr Ile Gln 340 345 350 Lys Asn Thr Ile Phe Thr Asn Val Ala Glu Thr Ser Asp Gly Gly Val 355 360 365 Tyr Trp Glu Gly Ile Asp Glu Pro Leu Ala Ser Gly Val Thr Ile Thr 370 375 380 Ser Trp Lys Asn Lys Glu Trp Ser Ser Glu Asp Gly Glu Pro Cys Ala 385 390 395 400 His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys Pro Ile Ile 405 410 415 Asp Ala Ala Trp Glu Ser Pro Glu Gly Val Pro Ile Glu Gly Ile Ile 420 425 430 Phe Gly Gly Arg Arg Pro Ala Gly Val Pro Leu Val Tyr Glu Ala Leu 435 440 445 Ser Trp Gln His Gly Val Phe Val Gly Ala Ala Met Arg Ser Glu Ala 450 455 460 Thr Ala Ala Ala Glu His Lys Gly Lys Ile Ile Met His Asp Pro Phe 465 470 475 480 Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Lys Tyr Leu Ala His 485 490 495 Trp Leu Ser Met Ala Gln His Pro Ala Ala Lys Leu Pro Lys Ile Phe 500 505 510 His Val Asn Trp Phe Arg Lys Asp Lys Glu Gly Lys Phe Leu Trp Pro 515 520 525 Gly Phe Gly Glu Asn Ser Arg Val Leu Glu Trp Met Phe Asn Arg Ile 530 535 540 Asp Gly Lys Ala Ser Thr Lys Leu Thr Pro Ile Gly Tyr Ile Pro Lys 545 550 555 560 Glu Asp Ala Leu Asn Leu Lys Gly Leu Gly His Ile Asn Met Met Glu 565 570 575 Leu Phe Ser Ile Ser Lys Glu Phe Trp Glu Lys Glu Val Glu Asp Ile 580 585 590 Glu Lys Tyr Leu Glu Asp Gln Val Asn Ala Asp Leu Pro Cys Glu Ile 595 600 605 Glu Arg Glu Ile Leu Ala Leu Lys Gln Arg Ile Ser Gln Met 610 615 620 <210> 363 <211> 457 <212> PRT <213> Homo sapiens <400> 363 Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 1 5 10 15 Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 20 25 30 Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 35 40 45 Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 50 55 60 Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 65 70 75 80 Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 85 90 95 Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 100 105 110 Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 115 120 125 Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 130 135 140 Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 145 150 155 160 Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 165 170 175 Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 180 185 190 Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 195 200 205 Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 210 215 220 Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 225 230 235 240 Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 245 250 255 Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 260 265 270 Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 275 280 285 Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 290 295 300 Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 305 310 315 320 Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 325 330 335 Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 340 345 350 Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 355 360 365 Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 370 375 380 Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 385 390 395 400 Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 405 410 415 Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 420 425 430 Val Phe Met Leu Val Cys Ile Ile Gly Thr Leu Ala Val Phe Ala Gly 435 440 445 Arg Leu Ile Glu Leu Asn Gln Gln Gly 450 455 <210> 364 <211> 264 <212> PRT <213> Homo sapiens <400> 364 Met Glu Ser Gly Phe Thr Ser Lys Asp Thr Tyr Leu Ser His Phe Asn 1 5 10 15 Pro Arg Asp Tyr Leu Glu Lys Tyr Tyr Lys Phe Gly Ser Arg His Ser 20 25 30 Ala Glu Ser Gln Ile Leu Lys His Leu Leu Lys Asn Leu Phe Lys Ile 35 40 45 Phe Cys Leu Asp Gly Val Lys Gly Asp Leu Leu Ile Asp Ile Gly Ser 50 55 60 Gly Pro Thr Ile Tyr Gln Leu Leu Ser Ala Cys Glu Ser Phe Lys Glu 65 70 75 80 Ile Val Val Thr Asp Tyr Ser Asp Gln Asn Leu Gln Glu Leu Glu Lys 85 90 95 Trp Leu Lys Lys Glu Pro Glu Ala Phe Asp Trp Ser Pro Val Val Thr 100 105 110 Tyr Val Cys Asp Leu Glu Gly Asn Arg Val Lys Gly Pro Glu Lys Glu 115 120 125 Glu Lys Leu Arg Gln Ala Val Lys Gln Val Leu Lys Cys Asp Val Thr 130 135 140 Gln Ser Gln Pro Leu Gly Ala Val Pro Leu Pro Pro Ala Asp Cys Val 145 150 155 160 Leu Ser Thr Leu Cys Leu Asp Ala Ala Cys Pro Asp Leu Pro Thr Tyr 165 170 175 Cys Arg Ala Leu Arg Asn Leu Gly Ser Leu Leu Lys Pro Gly Gly Phe 180 185 190 Leu Val Ile Met Asp Ala Leu Lys Ser Ser Tyr Tyr Met Ile Gly Glu 195 200 205 Gln Lys Phe Ser Ser Leu Pro Leu Gly Arg Glu Ala Val Glu Ala Ala 210 215 220 Val Lys Glu Ala Gly Tyr Thr Ile Glu Trp Phe Glu Val Ile Ser Gln 225 230 235 240 Ser Tyr Ser Ser Thr Met Ala Asn Asn Glu Gly Leu Phe Ser Leu Val 245 250 255 Ala Arg Lys Leu Ser Arg Pro Leu 260 <210> 365 <211> 579 <212> PRT <213> Homo sapiens <400> 365 Met Glu Val Asn Ala Gly Gly Val Ile Ala Tyr Ile Ser Ser Ser Ser 1 5 10 15 Ser Ala Ser Ser Pro Ala Ser Cys His Ser Glu Gly Ser Glu Asn Ser 20 25 30 Phe Gln Ser Ser Ser Ser Ser Val Pro Ser Ser Pro Asn Ser Ser Asn 35 40 45 Ser Asp Thr Asn Gly Asn Pro Lys Asn Gly Asp Leu Ala Asn Ile Glu 50 55 60 Gly Ile Leu Lys Asn Asp Arg Ile Asp Cys Ser Met Lys Thr Ser Lys 65 70 75 80 Ser Ser Ala Pro Gly Met Thr Lys Ser His Ser Gly Val Thr Lys Phe 85 90 95 Ser Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly 100 105 110 Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg 115 120 125 Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Lys Cys Leu Lys Asn Glu 130 135 140 Asn Cys Ser Ile Met Arg Met Asn Arg Asn Arg Cys Gln Gln Cys Arg 145 150 155 160 Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe 165 170 175 Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ile Glu Met Gln 180 185 190 Ser Ala Met Lys Thr Met Met Asn Ser Gln Phe Ser Gly His Leu Gln 195 200 205 Asn Asp Thr Leu Val Glu His His Glu Gln Thr Ala Leu Pro Ala Gln 210 215 220 Glu Gln Leu Arg Pro Lys Pro Gln Leu Glu Gln Glu Asn Ile Lys Ser 225 230 235 240 Ser Ser Pro Pro Ser Ser Asp Phe Ala Lys Glu Glu Val Ile Gly Met 245 250 255 Val Thr Arg Ala His Lys Asp Thr Phe Met Tyr Asn Gln Glu Gln Gln 260 265 270 Glu Asn Ser Ala Glu Ser Met Gln Pro Gln Arg Gly Glu Arg Ile Pro 275 280 285 Lys Asn Met Glu Gln Tyr Asn Leu Asn His Asp His Cys Gly Asn Gly 290 295 300 Leu Ser Ser His Phe Pro Cys Ser Glu Ser Gln Gln His Leu Asn Gly 305 310 315 320 Gln Phe Lys Gly Arg Asn Ile Met His Tyr Pro Asn Gly His Ala Ile 325 330 335 Cys Ile Ala Asn Gly His Cys Met Asn Phe Ser Asn Ala Tyr Thr Gln 340 345 350 Arg Val Cys Asp Arg Val Pro Ile Asp Gly Phe Ser Gln Asn Glu Asn 355 360 365 Lys Asn Ser Tyr Leu Cys Asn Thr Gly Gly Arg Met His Leu Val Cys 370 375 380 Pro Met Ser Lys Ser Pro Tyr Val Asp Pro His Lys Ser Gly His Glu 385 390 395 400 Ile Trp Glu Glu Phe Ser Met Ser Phe Thr Pro Ala Val Lys Glu Val 405 410 415 Val Glu Phe Ala Lys Arg Ile Pro Gly Phe Arg Asp Leu Ser Gln His 420 425 430 Asp Gln Val Asn Leu Leu Lys Ala Gly Thr Phe Glu Val Leu Met Val 435 440 445 Arg Phe Ala Ser Leu Phe Asp Ala Lys Glu Arg Thr Val Thr Phe Leu 450 455 460 Ser Gly Lys Lys Tyr Ser Val Asp Asp Leu His Ser Met Gly Ala Gly 465 470 475 480 Asp Leu Leu Asn Ser Met Phe Glu Phe Ser Glu Lys Leu Asn Ala Leu 485 490 495 Gln Leu Ser Asp Glu Glu Met Ser Leu Phe Thr Ala Val Val Leu Val 500 505 510 Ser Ala Asp Arg Ser Gly Ile Glu Asn Val Asn Ser Val Glu Ala Leu 515 520 525 Gln Glu Thr Leu Ile Arg Ala Leu Arg Thr Leu Ile Met Lys Asn His 530 535 540 Pro Asn Glu Ala Ser Ile Phe Thr Lys Leu Leu Leu Lys Leu Pro Asp 545 550 555 560 Leu Arg Ser Leu Asn Asn Met His Ser Glu Glu Leu Leu Ala Phe Lys 565 570 575 Val His Pro

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.⁷ 識別記号 ＦＩ テーマコート゛(参考） Ｃ１２Ｑ 1/02 Ｃ１２Ｑ 1/68 Ａ 1/68 Ｇ０１Ｎ 33/15 Ｚ Ｇ０１Ｎ 33/15 33/50 Ｚ 33/50 33/53 Ｍ 33/53 33/566 33/566 Ｃ０７Ｋ 16/18 // Ｃ０７Ｋ 16/18 Ｃ１２Ｎ 15/00 ＺＮＡＡ (72)発明者 林 浩司 大阪府大阪市此花区春日出中３丁目１番98 号 住友製薬株式会社内 Ｆターム(参考） 2G045 AA34 AA35 AA40 BA11 BB50 DA12 DA13 DA14 DA36 FB02 4B024 AA01 AA11 BA61 CA04 CA11 CA12 HA08 HA11 HA12 4B063 QA18 QA19 QQ02 QQ08 QQ53 QQ79 QR08 QR14 QR20 QR32 QR36 QR42 QR48 QR50 QR55 QR56 QR72 QR77 QS03 QS32 QS34 QS36 QX02 4C084 AA17 NA14 ZA702 ZC332 ZC352 4H045 AA10 AA11 AA20 AA30 BA09 CA40 DA75 DA76 EA27 EA50 FA72 FA73 FA74

Claims (25)

【特許請求の範囲】
1. 【請求項1】 配列番号：1、2、3、4、5、6、7、8、9、
   10、11、12、13、14、15、16、17、18、19、20、21、2
   2、23、24、25、26、27、28、29、30、31、32、33、3
   4、35、36、37、38、39、40、41、42、43、44、45、4
   6、47、48、49、50、51、52、53、54、55、56、57、5
   8、59、60、61、62、63、64、65、66、67、68、69、7
   0、71、72、73、74、75、76、77、78、79、80、81、8
   2、83、84、85、86、87、88、89、90、91、92、93、9
   4、95、96、97、98、99、100、101、102、103、104、10
   5、106、107、108、109、110、111、112、113、114、11
   5、116、117、118、119、120、121、122、123、124、12
   5、126、127、128、129、130、131、132、133、134、13
   5、136、137、138、139、140、141、142、143、144、14
   5、146、147、148、149、150、151、152、153、154、15
   5、156、157、158、159、160、161、162、163、164、16
   5、166、167、168、169、170、171、172、173、174、17
   5、176、177、178、179、180、181、182、183、184、18
   5、186、187、188、189、190、191、192、193、194、19
   5、196、197、198、199、200、201、202、203、204、20
   5、206、207、208、209、210、211、212、213、214、21
   5、216、217、218、219、220、221、222、223、224、22
   5、226、227、228、229、230、231、232、233、234、23
   5、236、237、238、239、240、241、242、243、244、24
   5、246、247、248、249、250、251、252、253、254、25
   5、256、257、258、259、260、314、315、316、317、31
   8、319、320、321、322、323、324、325、326、327、32
   8、329、330、331、332、333、334、335、336、337、33
   8、339、340、341、342、343、344、345、346、347、34
   8、349、350、351、352、353、354、355、356、357、35
   8、359、360および361で示されるいずれかの塩基配列に
   おいて、連続する少なくとも15塩基を有するポリヌクレ
   オチドおよび／または該ポリヌクレオチドに相補的なポ
   リヌクレオチドである糖代謝異常疾患の疾患マーカー。
2. 【請求項2】 糖代謝異常疾患の検出においてプローブ
   またはプライマーとして使用される請求項1に記載の疾
   患マーカー。
3. 【請求項3】 肝臓における疾患マーカーであって、配
   列番号：1、2、3、4、5、6、7、8、9、10、11、12、1
   3、14、15、16、17、18、19、20、21、22、23、24、2
   5、26、27、28、29、30、31、32、33、34、35、36、3
   7、38、39、40、41、42、43、44、45、46、47、48、4
   9、50、51、52、53、54、55、56、57、58、59、60、6
   1、62、63、64、65、66、67、68、69、70、71、72、7
   3、74、75、76、77、78、79、80、81、82、83、84、8
   5、86、87、88、89、90、91、92、93、94、95、96、9
   7、98、99、100、101、102、103、104、105、106、10
   7、108、109、110、111、112、113、114、115、116、11
   7、118、119、120、121、122、123、124、125、126、12
   7、128、129、130、131、132、133、134、135、136、13
   7、138、139、140、141、142、143、144、145、146、14
   7、148、149、150、151、152、153、154、155、156、15
   7、158、159、160、161、162、163、164、165、166、16
   7、168、169、170、171、172、173、174、175、176、17
   7、178、179、180、181、182、183、184、185、186、18
   7、188、189、190、191、192、193、194、195、196、19
   7、198、199、200、201、202、203、204、205、206、20
   7、208、209、210、211、212、213、214、215、216、21
   7、218、219、220、221、222、223、224、225、226、22
   7、228、229、230、231、232、233、234、235、236、23
   7、238、239、240、241、242、243、244、245、246、24
   7、248、249、250、251、252、253、254、255、256、25
   7、258、259および260で示されるいずれかの塩基配列に
   基づく疾患マーカーである請求項1または2に記載の疾患
   マーカー。
4. 【請求項4】 筋肉における疾患マーカーであって、配
   列番号：314、315、316、317、318、319、320、321、32
   2、323、324、325、326、327、328、329、330、331、33
   2、333、334、335、336、337、338、339、340、341、34
   2、343、344、345、346、347、348、349、350、351、35
   2、353、354、355、356、357、358、359、360および361
   で示されるいずれかの塩基配列に基づく疾患マーカーで
   ある請求項1または2に記載の疾患マーカー。
5. 【請求項5】 下記の工程(a)、(b)および(c)を含む糖代
   謝異常疾患の検出方法： (a) 被験者の生体試料から調製されたRNAまたは該RNAか
   ら転写された相補的ポリヌクレオチドと請求項1-4のい
   ずれかに記載の疾患マーカーとを結合させる工程、(b)
   該疾患マーカーに結合した生体試料由来のRNAまたは該R
   NAから転写された相補的ポリヌクレオチドを、上記疾患
   マーカーを指標として測定する工程、(c) 上記(b)の測
   定結果に基づいて、糖代謝異常疾患の罹患を判断する工
   程。
6. 【請求項6】 糖代謝異常疾患の罹患を判断する工程
   が、被験者について得られる測定結果を正常者について
   得られる測定結果と対比して、疾患マーカーへの結合量
   が増大していることを指標として判断するものである請
   求項5に記載の糖代謝異常疾患の検出方法。
7. 【請求項7】 生体試料が肝臓由来の組織または細胞で
   あり且つ疾患マーカーが請求項3に記載のものである請
   求項5または6に記載の方法。
8. 【請求項8】 生体試料が筋肉由来の組織または細胞で
   あり且つ疾患マーカーが請求項4に記載のものである請
   求項5または6に記載の方法。
9. 【請求項9】 配列番号：261、262、263、264、265、26
   6、267、268、269、270、271、272、273、274、275、27
   6、277、278、279、280、281、282、283、284、285、28
   6、287、288、289、290、291、292、293、294、295、29
   6、297、298、299、300、301、302、303、304、305、30
   6、307、308、309、310、311、312、313、362、363、36
   4および365で示されるいずれかのアミノ酸配列を有する
   蛋白質を認識する抗体である糖代謝異常疾患の疾患マー
   カー。
10. 【請求項10】 糖代謝異常疾患の検出においてプローブ
    として使用される請求項9に記載の疾患マーカー。
11. 【請求項11】 肝臓における疾患マーカーであって、配
    列番号：261、262、263、264、265、266、267、268、26
    9、270、271、272、273、274、275、276、277、278、27
    9、280、281、282、283、284、285、286、287、288、28
    9、290、291、292、293、294、295、296、297、298、29
    9、300、301、302、303、304、305、306、307、308、30
    9、310、311、312および313で示されるいずれかのアミ
    ノ酸配列に基づく疾患マーカーである請求項9または10
    に記載の疾患マーカー。
12. 【請求項12】 筋肉における疾患マーカーであって、配
    列番号：362、363、364および365で示されるいずれかの
    アミノ酸配列に基づく疾患マーカーである請求項9また
    は10に記載の疾患マーカー。
13. 【請求項13】 下記の工程(a)、(b)および(c)を含む糖
    代謝異常疾患の検出方法： (a) 被験者の生体試料から調製された蛋白質と請求項9-
    12のいずれかに記載の疾患マーカーとを結合させる工
    程、(b) 該疾患マーカーに結合した生体試料由来の蛋白
    質またはその部分ペプチドを、上記疾患マーカーを指標
    として測定する工程、(c) 上記(b)の測定結果に基づい
    て、糖代謝異常疾患の罹患を判断する工程。
14. 【請求項14】 糖代謝異常疾患の罹患を判断する工程
    が、被験者について得られる測定結果を正常者について
    得られる測定結果と対比して、疾患マーカーへの結合量
    が増大していることを指標として判断するものである請
    求項13に記載の糖代謝異常疾患の検出方法。
15. 【請求項15】 生体試料が肝臓由来の組織または細胞で
    あり且つ疾患マーカーが請求項11に記載のものである請
    求項13または14に記載の方法。
16. 【請求項16】 生体試料が筋肉由来の組織または細胞で
    あり且つ疾患マーカーが請求項12に記載のものである請
    求項13または14に記載の方法。
17. 【請求項17】 下記の工程(a)、(b)および(c)を含む配
    列番号：1、2、3、4、5、6、7、8、9、10、11、12、1
    3、14、15、16、17、18、19、20、21、22、23、24、2
    5、26、27、28、29、30、31、32、33、34、35、36、3
    7、38、39、40、41、42、43、44、45、46、47、48、4
    9、50、51、52、53、54、55、56、57、58、59、60、6
    1、62、63、64、65、66、67、68、69、70、71、72、7
    3、74、75、76、77、78、79、80、81、82、83、84、8
    5、86、87、88、89、90、91、92、93、94、95、96、9
    7、98、99、100、101、102、103、104、105、106、10
    7、108、109、110、111、112、113、114、115、116、11
    7、118、119、120、121、122、123、124、125、126、12
    7、128、129、130、131、132、133、134、135、136、13
    7、138、139、140、141、142、143、144、145、146、14
    7、148、149、150、151、152、153、154、155、156、15
    7、158、159、160、161、162、163、164、165、166、16
    7、168、169、170、171、172、173、174、175、176、17
    7、178、179、180、181、182、183、184、185、186、18
    7、188、189、190、191、192、193、194、195、196、19
    7、198、199、200、201、202、203、204、205、206、20
    7、208、209、210、211、212、213、214、215、216、21
    7、218、219、220、221、222、223、224、225、226、22
    7、228、229、230、231、232、233、234、235、236、23
    7、238、239、240、241、242、243、244、245、246、24
    7、248、249、250、251、252、253、254、255、256、25
    7、258、259、260、314、315、316、317、318、319、32
    0、321、322、323、324、325、326、327、328、329、33
    0、331、332、333、334、335、336、337、338、339、34
    0、341、342、343、344、345、346、347、348、349、35
    0、351、352、353、354、355、356、357、358、359、36
    0および361で示されるいずれかの塩基配列を有する遺伝
    子の発現を抑制する物質のスクリーニング方法： (a) 被験物質と上記配列番号で示されるいずれかの塩基
    配列を有する遺伝子またはそのホモログを発現可能な細
    胞とを接触させる工程、(b) 被験物質を接触させた細胞
    における上記遺伝子またはそのホモログの発現量を測定
    し、該発現量を被験物質を接触させない対照細胞におけ
    る同一遺伝子またはそのホモログの発現量と比較する工
    程、(c) 上記(b)の比較結果に基づいて、上記遺伝子ま
    たはそのホモログの発現量を抑制する被験物質を選択す
    る工程。
18. 【請求項18】 糖代謝異常疾患の予防、改善または治療
    剤の有効成分を探索するための方法である請求項17に記
    載のスクリーニング方法。
19. 【請求項19】 下記の工程(a)、(b)および(c)を含む配
    列番号：261、262、263、264、265、266、267、268、26
    9、270、271、272、273、274、275、276、277、278、27
    9、280、281、282、283、284、285、286、287、288、28
    9、290、291、292、293、294、295、296、297、298、29
    9、300、301、302、303、304、305、306、307、308、30
    9、310、311、312、313、362、363、364および365で示
    されるいずれかのアミノ酸配列を有する蛋白質の発現量
    を減少させる物質のスクリーニング方法： (a)被験物質と配列番号：261、262、263、264、265、26
    6、267、268、269、270、271、272、273、274、275、27
    6、277、278、279、280、281、282、283、284、285、28
    6、287、288、289、290、291、292、293、294、295、29
    6、297、298、299、300、301、302、303、304、305、30
    6、307、308、309、310、311、312、313、362、363、36
    4および365で示されるいずれかのアミノ酸配列を有する
    蛋白質またはそのホモログを発現可能な細胞または該細
    胞から調製した細胞画分とを接触させる工程、(b)被験
    物質を接触させた細胞または細胞画分における配列番
    号：261、262、263、264、265、266、267、268、269、2
    70、271、272、273、274、275、276、277、278、279、2
    80、281、282、283、284、285、286、287、288、289、2
    90、291、292、293、294、295、296、297、298、299、3
    00、301、302、303、304、305、306、307、308、309、3
    10、311、312、313、362、363、364および365で示され
    るいずれかのアミノ酸配列を有する蛋白質またはそのホ
    モログの発現量を測定し、該発現量を被験物質を接触さ
    せない対照細胞もしくは細胞画分における上記配列番
    号：261、262、263、264、265、266、267、268、269、2
    70、271、272、273、274、275、276、277、278、279、2
    80、281、282、283、284、285、286、287、288、289、2
    90、291、292、293、294、295、296、297、298、299、3
    00、301、302、303、304、305、306、307、308、309、3
    10、311、312、313、362、363、364および365で示され
    るいずれかのアミノ酸配列を有する蛋白質またはそのホ
    モログの発現量と比較する工程、(c)上記(b)の比較結果
    に基づいて、配列番号：261、262、263、264、265、26
    6、267、268、269、270、271、272、273、274、275、27
    6、277、278、279、280、281、282、283、284、285、28
    6、287、288、289、290、291、292、293、294、295、29
    6、297、298、299、300、301、302、303、304、305、30
    6、307、308、309、310、311、312、313、362、363、36
    4および365で示されるいずれかのアミノ酸配列を有する
    蛋白質またはそのホモログの発現量を減少させる被験物
    質を選択する工程。
20. 【請求項20】 下記の工程(a)、(b)および(c)を含む配
    列番号：261、262、263、264、265、266、267、268、26
    9、270、271、272、273、274、275、276、277、278、27
    9、280、281、282、283、284、285、286、287、288、28
    9、290、291、292、293、294、295、296、297、298、29
    9、300、301、302、303、304、305、306、307、308、30
    9、310、311、312、313、362、363、364および365で示
    されるいずれかのアミノ酸配列を有する蛋白質の機能ま
    たは活性を抑制する物質のスクリーニング方法： (a)被験物質と配列番号：261、262、263、264、265、26
    6、267、268、269、270、271、272、273、274、275、27
    6、277、278、279、280、281、282、283、284、285、28
    6、287、288、289、290、291、292、293、294、295、29
    6、297、298、299、300、301、302、303、304、305、30
    6、307、308、309、310、311、312、313、362、363、36
    4および365で示されるいずれかのアミノ酸配列を有する
    蛋白質またはそのホモログを含む水溶液、細胞または該
    細胞から調製した細胞画分とを接触させる工程、(b)被
    験物質を接触させた水溶液、細胞または細胞画分におけ
    る配列番号：261、262、263、264、265、266、267、26
    8、269、270、271、272、273、274、275、276、277、27
    8、279、280、281、282、283、284、285、286、287、28
    8、289、290、291、292、293、294、295、296、297、29
    8、299、300、301、302、303、304、305、306、307、30
    8、309、310、311、312、313、362、363、364および365
    で示されるいずれかのアミノ酸配列を有する蛋白質また
    はそのホモログの機能または活性を測定し、該機能また
    は活性を被験物質を接触させない対照水溶液または対照
    細胞もしくは細胞画分における上記配列番号：261、26
    2、263、264、265、266、267、268、269、270、271、27
    2、273、274、275、276、277、278、279、280、281、28
    2、283、284、285、286、287、288、289、290、291、29
    2、293、294、295、296、297、298、299、300、301、30
    2、303、304、305、306、307、308、309、310、311、31
    2、313、362、363、364および365で示されるいずれかの
    アミノ酸配列を有する蛋白質またはそのホモログの機能
    または活性と比較する工程、(c)上記(b)の比較結果に基
    づいて、配列番号：261、262、263、264、265、266、26
    7、268、269、270、271、272、273、274、275、276、27
    7、278、279、280、281、282、283、284、285、286、28
    7、288、289、290、291、292、293、294、295、296、29
    7、298、299、300、301、302、303、304、305、306、30
    7、308、309、310、311、312、313、362、363、364およ
    び365で示されるいずれかのアミノ酸配列を有する蛋白
    質またはそのホモログの機能または活性を抑制する被験
    物質を選択する工程。
21. 【請求項21】糖代謝異常疾患の予防、改善または治療剤
    の有効成分を探索するための方法である、請求項19また
    は20に記載のスクリーニング方法。
22. 【請求項22】 配列番号：1、2、3、4、5、6、7、8、
    9、10、11、12、13、14、15、16、17、18、19、20、2
    1、22、23、24、25、26、27、28、29、30、31、32、3
    3、34、35、36、37、38、39、40、41、42、43、44、4
    5、46、47、48、49、50、51、52、53、54、55、56、5
    7、58、59、60、61、62、63、64、65、66、67、68、6
    9、70、71、72、73、74、75、76、77、78、79、80、8
    1、82、83、84、85、86、87、88、89、90、91、92、9
    3、94、95、96、97、98、99、100、101、102、103、10
    4、105、106、107、108、109、110、111、112、113、11
    4、115、116、117、118、119、120、121、122、123、12
    4、125、126、127、128、129、130、131、132、133、13
    4、135、136、137、138、139、140、141、142、143、14
    4、145、146、147、148、149、150、151、152、153、15
    4、155、156、157、158、159、160、161、162、163、16
    4、165、166、167、168、169、170、171、172、173、17
    4、175、176、177、178、179、180、181、182、183、18
    4、185、186、187、188、189、190、191、192、193、19
    4、195、196、197、198、199、200、201、202、203、20
    4、205、206、207、208、209、210、211、212、213、21
    4、215、216、217、218、219、220、221、222、223、22
    4、225、226、227、228、229、230、231、232、233、23
    4、235、236、237、238、239、240、241、242、243、24
    4、245、246、247、248、249、250、251、252、253、25
    4、255、256、257、258、259、260、314、315、316、31
    7、318、319、320、321、322、323、324、325、326、32
    7、328、329、330、331、332、333、334、335、336、33
    7、338、339、340、341、342、343、344、345、346、34
    7、348、349、350、351、352、353、354、355、356、35
    7、358、359、360および361で示されるいずれかの塩基
    配列を有する遺伝子の発現を抑制する物質を有効成分と
    する糖代謝異常疾患の予防、改善または治療剤。
23. 【請求項23】 遺伝子の発現を抑制する物質が請求項17
    に記載のスクリーニング法により得られるものである請
    求項22に記載の糖代謝異常疾患の予防、改善または治療
    剤。
24. 【請求項24】 配列番号：261、262、263、264、265、26
    6、267、268、269、270、271、272、273、274、275、27
    6、277、278、279、280、281、282、283、284、285、28
    6、287、288、289、290、291、292、293、294、295、29
    6、297、298、299、300、301、302、303、304、305、30
    6、307、308、309、310、311、312、313、362、363、36
    4および365で示されるいずれかのアミノ酸配列を有する
    蛋白質の発現量、機能または活性を抑制する物質を有効
    成分とする糖代謝異常疾患の予防、改善または治療剤。
25. 【請求項25】 配列番号：261、262、263、264、265、26
    6、267、268、269、270、271、272、273、274、275、27
    6、277、278、279、280、281、282、283、284、285、28
    6、287、288、289、290、291、292、293、294、295、29
    6、297、298、299、300、301、302、303、304、305、30
    6、307、308、309、310、311、312、313、362、363、36
    4および365で示されるいずれかのアミノ酸配列を有する
    蛋白質の発現量、機能または活性を抑制する物質が、請
    求項19または20に記載のスクリーニング方法により得ら
    れるものである請求項24に記載の糖代謝異常疾患の予
    防、改善または治療剤。