JP2003055234A - FOOD AND BEVERAGE AND PROPHYLACTIC MEDICINE FOR CANCER AND THERAPEUTIC MEDICINE FOR CANCER EACH CONTAINING beta(1-3)D-GLUCAN AND FUCOIDAN - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve a problem in which Agaricus mushroom used for prevention and treatment of cancer at present has a slight effect even when used together with fucoidan, because the Agaricus mushroom comprises β(1-6)D-glucan as a main ingredient. SOLUTION: The food or beverage or the prophylactic medicine for cancers or the therapeutic medicine for cancers comprises β(1-3)D-glucan and fucoidan and has a synergistic effect of anticancer property of β(1-3)D-glucan of Sparassis crispa and apoptosis of cancer cell of fucoidan. As a result, it is expected that beverages or foods obtained by mixing these ingredients with various beverages or foods prevent cancers. The therapeutic effect of the therapeutic medicine against cancer was also confirmed.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to foods and drinks containing β (1-3) D-glucan and fucoidan, which are the main components of Ganoderma lucidum, and cancer preventive and cancer therapeutic agents.

[0002]

2. Description of the Related Art As for artificial cultivation of Hanabitake mushroom, as described in JP-A No. 11-56098, sawdust chips or chips containing larch wood as a main component are heated in the presence of water to dissolve hot water soluble components. After removal, it succeeded by adding a nutritional component.
-217543 Bamboo shoots extract.

Research on fucoidan has a history of nearly 100 years, and many patents have been applied for. In recent patents, there is JP-A-2001-181303 fucoidan-like polysaccharide complex, a method for producing the same, and an immunostimulant containing the same as a main component. Macrophages (Mφ), which is an important member of immunity formation by killing the urine, preventing canceration of tissues at an early stage, enhancing natural killer cell (NK) activity that is important for disease prevention and maintaining health, and removing invading foreign substances. It is an object of the present invention to provide a fucodyne-like polysaccharide complex having a liver damage-relieving action as well as enhancing a bioprotective ability activating activity by enhancing an anorexic diet. There is.

As a food containing β-glucan and fucoidan that assists cell suicide (apoptosis), there is a method for producing an immune food for treating cancer as disclosed in JP-A-10-33142. When treating cancer, this patent omnidirectionally combines multiple types of medicinal components with different directions of action and effect, cultivates its synergistic effect and apoptosis (cell suicide) action, making cancer cells into bags A method for producing an immune food for treating cancer, which achieves siege and eradication, and is constituted by effectively combining U-fucoidan, D-fraction, β-glucan, organogermanium, and other polysaccharides. The β-glucan used in this patent is described as agaricus mushroom and maitake mushroom. The β-glucan of agaricus mushroom and Maitake is β- (1-6). In the case of Agaricus, its strength is that it contains plant steroids, and β- (1
It is effective in treating cancer by reinforcing the weakness of (6).

[0005]

SUMMARY OF THE INVENTION Therefore, Japanese Patent Laid-Open No. 10-
The β-glucan described in 33142 is β- (1-
6), and the effect of this substance in treating cancer is not very high, and U-fucoidan, D-fraction, β-glucan,
Even if combined with organic germanium, the effect is small because β-glucan is β- (1-6).

[0006]

[Means for Solving the Problems] The present invention provides an anticancer drug, a food and drink containing Fucoidan as a main component, which contains a large amount of β- (1-3) D-glucan which strongly acts on the enhancement of immunity. The aim is to provide foods and drinks that have strong anti-cancer properties and immunity enhancement, which are agaricus mushrooms, irreversible.

[0007] The β (1-
3) As for D-glucan, in foods and drinks to be heated, there are cases where Hanabitake mushrooms are finely crushed and used, and those which are extracted from Hanabitake mushrooms are used. When it is not heated, β (1-3) D-glucan extracted from Bamboo shoots is used.

The method for extracting β-1,3-glucan from Ganoderma lucidum is according to the extract of Ganoderma lucidum 2000-217543. This method is based on hot water or alkali extraction. Use this.

The fucoidan according to claims 1 and 3 of the present invention can be used in foods and drinks to be heated, such as kelp, mozuku,
There are cases where seaweed such as mekabu is finely crushed and used, and cases where fucoidan extracted from seaweed is used. If not heated, use fucoidan extracted from seaweed.

A known method is used to extract various fucoidans from seaweed. For example, according to WO 97/47208, fucoidan-U or fucoidan-F performed in the presence of a calcium salt or in an alkaline solution, a method of extracting fucoidan with pressurized hot water using an autoclave from Okinawa mozuku of JP 2000-239301 A, JP 2000 -23688
After swelling the Okinawa mozuku of 9 with an organic acid salt,
Method for extracting fucoidan by enzymatic treatment with fucoidan-degrading enzyme, GA from konjac-produced rhizome
Any of fucoidan, L-fucoidan, etc. may be used. As a commercial item, Marui Bussan Co., Ltd.'s spoidan,
TaKaRa Kombu Fucoidan from Takara Shuzo Co., Ltd., Fucoidan from Okinawa Fermentation Co., Ltd., etc. are used.

A fourth aspect of the present invention is a cancer preventive and cancer therapeutic agent comprising Hanabitake mushroom extract or Hanabitake mushroom extract powder, fucoidan, liquid sugar, royal jelly, vitamin C, sodium benzoate, and caramel. Hanabitake mushroom extract is manufactured by the method of Japanese Patent Laid-Open No. 2000-217543 Hanabitake mushroom extract, and Hanabitake mushroom extract powder is manufactured from Hanabitake mushroom extract. Any fucoidan may be used, but iodine has been removed in consideration of thyroid patients and excessive intake. This fucoidan cancer cell apoptosis (suicide) and β (1-3) D
-The anticancer synergistic effect of glucan makes it effective as a preventive and therapeutic drug for cancer. Liquid sugar and caramel are used for ease of drinking and seasoning. Royal jelly and Vitamin C are added more than other health foods for both beauty and health. Sodium benzoate is a stabilizer.

[0012] A fifth aspect of the present invention is a drink in which a tea-based beverage such as green tea or oolong tea is supplemented with Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan. A patent for adding fucoidan to tea beverages is Japanese Patent Laid-Open No. 2000-1163.
There are 27. This patent is to prevent the formation of floc which occurs during storage of tea beverages by adding fucoidan. For cold green tea, oolong tea, etc. packed in plastic bottles, Hanabitake mushroom extract or Hanabitake mushroom extract powder extracted from Hanabitake mushroom and fucoidan extracted from seaweed are used. It is used for green tea leaves, and when drinking tea with hot water, Hanabitake mushrooms and seaweed are sometimes directly crushed and used.

[0016] A sixth aspect of the present invention is a drink prepared by adding to the carbonated drink, the fruit drink, etc., the powder of Hanabitake mushroom extract or the powder of Hanabitake mushroom extract and fucoidan. Since most of them are cold drinks, we use Hanabitake mushroom extract or Hanabitake mushroom extract powder extracted from Hanabitake mushroom and fucoidan extracted from seaweed.

[0014] A seventh aspect of the present invention is a drink in which the powder of Hanabi-take mushroom or powder of Hanabi-take mushroom extract and fucoidan are added to mineral water or natural water. In this case, the Hanabitake mushroom extract or the Hanabitake mushroom extract powder extracted from the odorless and odorless Hanabitake mushroom, or the fucoidan extracted from seaweed is used.

The eighth aspect of the present invention relates to a milk drink, soy milk, and the like, which is obtained by adding Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan extracted from seaweed.

[0016] A ninth aspect of the present invention is a drink comprising a vegetable drink such as tomato juice and the like, which is prepared by adding Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan extracted from seaweed.

[0017] A tenth aspect of the present invention is a sports drink to which the Hanabitake mushroom extract or the Hanabitake mushroom extract powder and fucoidan extracted from seaweed are added.

The eleventh aspect of the present invention is a seasoning in which various kinds of seasonings such as miso and soy sauce are added with Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan. When making miso soup, it is heated, so you can use seaweed and Hanabitake mushrooms directly. Other than that, there is a strong possibility that both cold use and warm use will be mixed, so Hanabitake extract or Hanabitake extract powder extracted from Hanabitake mushroom and fucoidan extracted from seaweed are used.

[0019]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention is a food, drink, and cancer preventive and therapeutic drug containing Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan. Here, Claim 4 describes a drug for preventing and treating cancer, which comprises Hanabitake mushroom extract or Hanabitake mushroom extract powder, fucoidan, liquid sugar, royal jelly, vitamin C, sodium benzoate, and caramel.

The powder of Hanabitake mushroom extract is disclosed in Japanese Patent Laid-Open No. 2000-
217543 manufactured by the method of Ganoderma lucidum extract.
As the fucoidan, a commercially available product is used. For example, Marui Bussan Co., Ltd.'s spoidan, Takara Shuzo Co., Ltd.'s TaKaRa konbu fucoidan, Okinawa Fermentation Chemical's fucoidan, and the like. In this case, iodine-removed items are selected in consideration of thyroid patients and excessive intake. Liquid sugar, royal jelly, vitamin C, sodium benzoate, and caramel are selected from commercial products.

[0021]

EXAMPLE The following will describe claim 4 of the present invention with reference to an example, but claim 4 of the present invention is not limited thereto.

600 g of Hanabitake mushroom extract powder, 200 g of fucoidan, 2,580 g of liquid sugar, 50 of royal jelly
g, vitamin C 1 g, benzoic acid 5 g, caramel 103 g
Purified water is added to and the total volume is adjusted to 10 liters. After thoroughly stirring and mixing these, complete sterilization and fermentation prevention, air shutoff and vacuum packaging are performed.

10 m of a drug for preventing and treating cancer, which comprises the powder of Hanabitake mushroom extract, fucoidan, liquid sugar, royal jelly, vitamin C, sodium benzoate, and caramel.
The compounding amount in 1 is shown in Table 1.

[0024]

[Table 1]

[Table 1]

[0025]

EFFECTS OF THE INVENTION The synergistic effect of β (1-3) D-glucan of Hanabitake mushroom and apoptosis (suicide) of cancer cells of fucoidan is expected to prevent cancer by mixing with various foods and drinks. Moreover, the effect as a cancer therapeutic agent was also confirmed.

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Claims (11)

[Claims] 1. A food or drink containing β (1-3) D-glucan and fucoidan, and a drug for preventing or treating cancer. 2. The food or drink according to claim 1, wherein the β (1-3) D-glucan is produced from Hanabitake mushroom, and a drug for preventing or treating cancer. 3. The food and drink according to claim 1, cancer preventive and cancer therapeutic agents, wherein fucodine is seaweed such as kelp, mozuku, mekabu, and various fucoidans extracted from these seaweeds. 4. An agent for preventing or treating cancer, which comprises Hanabitake mushroom extract or Hanabitake mushroom extract powder, fucoidan, liquid sugar, royal jelly, vitamin C, sodium benzoate, and caramel. 5. A drink comprising a tea-based beverage such as green tea, oolong tea, etc., added with Hanabitake mushroom extract powder, Hanabitake mushroom extract powder, or Hanabitake mushroom powder and fucoidan. 6. A drink prepared by adding fucoidan and powdered Hanabi-take mushroom extract or powdered Hanabi-take mushroom extract to carbonated drinks, fruit drinks and the like. 7. A drink prepared by adding fucoidan and powder of Hanabi-take mushroom extract or Hanabi-take mushroom extract to mineral water or natural water. 8. A drink prepared by adding hanabitake mushroom extract or hanabitake mushroom extract powder and fucoidan to dairy drinks, soy milk and the like. 9. A drink prepared by adding Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan to a vegetable drink such as tomato juice. 10. A drink prepared by adding Hanabitake mushroom extract or Hanabitake mushroom extract powder and fucoidan to a sports drink. 11. Seasonings such as miso, soy sauce, and the like, which are prepared by adding Hanabitake mushroom extract, Hanabitake mushroom extract powder, or Hanabitake mushroom powder and fucoidan.