JP2002345493A - New gene and protein encoded by the gene - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a DNA, a gene including the DNA, a recombinant polypeptide encoded by the DNA and a new recombinant protein including the polypeptide by directly cloning a new DNA including a region encoding the protein from a cDNA library derived from a human adult whole brain, a human adult hippocampus and a human fetal whole brain, determining the base sequence of the new DNA, and furthermore identifying the function thereof. SOLUTION: Disclosed are a DNA comprising a base sequence encoding a polypeptide represented by the following (a) or (b): (a) a polypeptide comprising a same or practically same amino acid sequence as an amino acid sequence represented by either one of SEQ ID NO: 1-63 (except for SEQ ID NO: 52) (refer to the specification); (b) a polypeptide comprising an amino acid sequence in which some amino acids are deleted, substituted or added from/for/to the amino acid sequence represented by either one of SEQ ID NO: 1-63 (except for SEQ ID NO: 52) and having a practically equal biological activity to the function of the polypeptide of (a), a recombinant polypeptide encoded by the DNA and a protein including the polypeptide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to DNA and the DN
The present invention relates to a gene containing A, a recombinant polypeptide encoded by the DNA, and a novel recombinant protein containing the polypeptide.

[0002]

2. Description of the Related Art Information on the nucleotide sequence of the human genome is being produced daily by large-scale sequencing in the Human Genome Project. The ultimate goal of the Human Genome Project is not simply to determine the entire nucleotide sequence of the genome, but to interpret various human phenomena from its structural information, that is, the nucleotide sequence information of DNA. The region encoding a protein in the human genome sequence is a very small part of the region. At present, the coding region is predicted using a neutral network or an information science technique called a hidden Markov model. However, their prediction accuracy is not yet sufficient.

[0003] In order to find novel genes, the present inventors have directly synthesized novel DNA containing a protein-encoding region from a cDNA library derived from human adult whole brain, human adult hippocampus and human fetal whole brain. The cloning was successful and their nucleotide sequences were determined to complete the present invention.

[0004]

That is, as a first aspect, the present invention relates to a DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) SEQ ID NO: 1 To 63 (excluding 52), a polypeptide consisting of the same or substantially the same amino acid sequence as shown in any one of (b) SEQ ID NOs: 1 to 63 (excluding 52) In the amino acid sequence represented by any one of the above, the amino acid sequence comprises an amino acid sequence in which some amino acids are deleted, substituted or added, and has a biological activity substantially equivalent to the function of the polypeptide of (a). Polypeptide. As a second aspect of the present invention, the present invention relates to the following DNA (a) or (b): (a) SEQ ID NOs: 1 to 63
(However, excluding 52), a DNA containing the nucleotide sequence encoding the amino acid sequence represented by each sequence, or the DNA of (b) or (a) under stringent conditions. And hybridized with (a)
DNA encoding a protein having substantially the same biological activity as the function of the polypeptide. The above-mentioned DNAs according to the first and second aspects of the present invention are collectively referred to as “DNA of the present invention” hereinafter. The present invention also relates to genes containing these DNAs. Furthermore, the present invention relates to a recombinant polypeptide encoded by the above DNA or gene (hereinafter, also referred to as “the polypeptide of the present invention”), and a recombinant protein containing the polypeptide.

[0005] The names of the clones having the DNA of the present invention, the length of the polypeptide or protein of the present invention, and their functions are shown in Tables 1 to 3.

The DNA of the present invention is prepared by using the commercially available mRNA of human adult whole brain, human adult hippocampus and human fetal whole brain (Clontech) as a starting material.
After isolation as a cDNA fragment from a DNA library, the nucleotide sequence was determined and identified. That is, specifically, the method of Ohara et al. (DNA Research Vol. 4, 53-59)
(1997)). Clones are randomly isolated from cDNA libraries derived from human adult whole brain, human adult hippocampus and human fetal whole brain prepared according to (1997)). Next, the duplicated clones (clones that repeatedly appear) were removed by hybridization, followed by in vitro transcription and translation.
The nucleotide sequence of both ends of a clone in which a product of kDa or more is recognized is determined. Further, a homology search is performed in a database of known genes using the thus obtained terminal nucleotide sequence as a query, and as a result, the entire nucleotide sequence is determined for a clone that has been found to be novel. In this manner, an unknown gene that cannot be obtained by a conventional cloning method depending on a known gene can be systematically cloned. The entire region of the human-derived gene including the DNA of the present invention can also be obtained by using a PCR method such as RACE while paying sufficient attention so that artificial errors do not occur in the short fragment or the obtained sequence. It is also possible to prepare.

Further, the present invention provides a recombinant vector containing the DNA of the present invention or a gene containing the DNA of the present invention, a transformant carrying the recombinant vector, and culturing the transformant to obtain the polypeptide or the polypeptide of the present invention. A method for producing a polypeptide of the present invention, a recombinant protein containing the polypeptide, or a salt thereof, which comprises producing, accumulating, and collecting a recombinant protein containing the polypeptide, and a method for producing the same. The present invention provides a polypeptide of the present invention, a recombinant protein containing the polypeptide, or a salt thereof.

[0008] The present invention also relates to a pharmaceutical comprising the DNA or gene of the present invention, a polynucleotide of the present invention or a partial polypeptide thereof or a polynucleotide comprising a base sequence encoding a recombinant protein containing the polypeptide (DN).
A), an antisense nucleotide having a nucleotide sequence substantially complementary to the nucleotide sequence, a medicament containing the polynucleotide or the antisense nucleotide, a polypeptide of the present invention or a partial polypeptide thereof, and
The present invention relates to a medicament comprising the polypeptide or a recombinant protein containing the polypeptide. Furthermore, the present invention provides an antibody against the polypeptide of the present invention or a partial polypeptide thereof or a recombinant protein containing the polypeptide or a salt thereof, and
A screening method and a screening method for a substance that specifically interacts with the polypeptide of the present invention, a partial polypeptide thereof, a recombinant protein containing the polypeptide or a salt thereof, or an antibody against the substance. The present invention also relates to a kit for use, a substance (compound) itself identified by the screening method, and the like.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The DNA of the present invention may be any DNA as long as it comprises a base sequence encoding the polypeptide of the present invention described above. Also, human brain, or other tissues, such as heart, lung, liver,
CDNA derived from cells / tissues such as spleen, kidney, testis, etc.
CDNA identified and isolated from a library or the like, or
Any of synthetic DNAs may be used. The vector used for the library construction may be any of bacteriophage, plasmid, cosmid, phagemid and the like. In addition, the total RNA fraction or m
Using the prepared RNA fraction, direct ReverseTrans
cription coupled Polymerase Chain Reaction
It can also be amplified by the "RT-PCR method".

An amino acid sequence substantially the same as the amino acid sequence represented by any one of SEQ ID NOs: 1 to 63 (excluding 52) includes SEQ ID NOs: 1 to 63 (excluding 52) The degree of homology with the entire amino acid sequence represented by any one of
Preferably, it means an amino acid sequence that is about 80% or more, more preferably about 90% or more, and particularly preferably about 95% or more. Accordingly, the polypeptide of the present invention comprising an amino acid sequence substantially identical to the amino acid sequence represented by any one of SEQ ID NOs: 1 to 63 (excluding 52) includes, for example, each of the aforementioned SEQ ID NOs: And a polypeptide having the above homology to the amino acid sequence represented by the above and having a biological activity (function) substantially equivalent to the function of the polypeptide consisting of the amino acid sequence represented by each SEQ ID NO: Can be done. Here, “substantially the same quality” means that their activities (functions) are the same in nature.
Further, the polypeptide of the present invention includes, for example, a part (preferably, about 1 to 20 amino acids) in the amino acid sequence represented by any one of SEQ ID NOs: 1 to 63 (excluding 52).
More preferably, it comprises an amino acid sequence in which about 1 to 10 amino acids have been deleted, substituted or added, or an amino acid sequence obtained by combining them, and SEQ ID NOS: 1 to 63 (excluding 52 ), The polypeptide having substantially the same biological activity (function) as the function of the polypeptide comprising the amino acid sequence represented by any one of the above.

The above-mentioned SEQ ID NOs: 1 to 63 (however, 52
A) a polypeptide consisting of an amino acid sequence substantially identical to the amino acid sequence shown in any one of the above, or a polypeptide consisting of an amino acid sequence in which some amino acids have been deleted, substituted or added, Site-directed mutagenesis, homologous recombination, primer extension, and P
It can be easily created by appropriately combining methods known to those skilled in the art such as the CR method. At this time, in order to have substantially the same biological activity, among the amino acids constituting the polypeptide, homologous amino acids (polar and
Non-polar amino acids, hydrophobic / hydrophilic amino acids, positive / negative charged amino acids, aromatic amino acids, etc.) are considered as possible. In order to maintain substantially the same biological activity, it is desirable that amino acids in the functional domain contained in each polypeptide of the present invention be retained.

Further, the DNA of the present invention includes, in the nucleotide sequence represented by any one of SEQ ID NOs: 1 to 63 (excluding 52), a nucleotide sequence encoding the amino acid sequence represented by each sequence. Encodes a DNA and a polypeptide (protein) that hybridizes with the DNA under stringent conditions and has the same biological activity (function) as the function of the polypeptide consisting of the amino acid sequence represented by each sequence. DNA. Under such conditions,
In the base sequence represented by any one of SEQ ID NOs: 1 to 63 (excluding 52), as a DNA capable of hybridizing with a DNA containing a base sequence encoding the amino acid sequence represented by each sequence, for example, , The DNA
Has a degree of homology with all nucleotide sequences of about 80 on average.
%, Preferably about 90% or more, more preferably about 9%
Examples include DNAs containing a base sequence of 5% or more. Hybridization is performed using Current Protocols in Molecular Biology (Cu
rrent protocols in molecular biology (edited by Fr
ederick M. Ausubel et al., 1987)), or a method known in the art or a method analogous thereto. When a commercially available library is used, it can be performed according to the method described in the attached instruction manual. Here, “stringent conditions” refers to, for example, 1 mM sodium EDTA at 65 ° C., 0.5
M sodium hydrogen phosphate (pH 7.2), hybridized in 7% SDS aqueous solution, 1 mM sodium EDTA at 40 ° C, 40 mM sodium hydrogen phosphate (pH 7.2), 1% SDS
The condition is such that hybridization to the DNA probe of the present invention is performed by Southern blot hybridization under conditions in which the membrane is washed in an aqueous solution.

As a means for cloning the DNA of the present invention, the DNA is amplified by the PCR method using a synthetic DNA primer having an appropriate nucleotide sequence such as a portion of the polypeptide of the present invention, or the DNA incorporated into an appropriate vector is used as the cloning DNA. Selection can be made by hybridization with a DNA fragment encoding a part or all of the polypeptide of the invention or labeled with a synthetic DNA. The hybridization method is, for example, as described above.
Current protocols in molecular biology (edited by
Frederick M. Ausubel et al., 1987). When a commercially available library is used, it can be performed according to the method described in the attached instruction manual. The DNA encoding the cloned polypeptide can be used as it is depending on the purpose, or can be used after digesting with a restriction enzyme or adding a linker, if desired. The DNA may have ATG as a translation initiation codon at the 5 'end and TAA, TGA or TAG as a translation stop codon at the 3' end. These translation initiation codon and translation termination codon can also be added using a suitable synthetic DNA adapter.

The expression vector of the protein of the present invention can be prepared according to a method known in the art. For example, it can be produced by cutting out (1) a DNA fragment containing the DNA of the present invention or a gene containing the DNA of the present invention, and (2) ligating the DNA fragment downstream of a promoter in an appropriate expression vector. As the vector, a plasmid derived from Escherichia coli (eg, pBR322, pB
R325, pUC18, pUC118) and plasmids derived from Bacillus subtilis (eg, pUB110, pTP5, pC19)
4), yeast-derived plasmids (eg, pSH19, pSH1
5), bacteriophages such as λ phage, and animal viruses such as retrovirus, vaccinia virus, and baculovirus can be used. The promoter used in the present invention may be any promoter as long as it is appropriate for the host used for gene expression. For example, if the host is E. coli, trp
Promoter, lac promoter, recA promoter, λPL promoter, lpp promoter, etc., when the host is Bacillus subtilis, SPO1 promoter, SPO2 promoter, penP promoter, etc., when the host is yeast, PHO5 promoter
PGK promoter, GAP promoter, ADH promoter and the like are preferable. When animal cells are used as a host, SRα promoter, SV40 promoter,
LTR promoter, CMV promoter, HSV-T
K promoter and the like.

[0015] In addition to the above, the expression vector may further include an enhancer, a splicing signal, a polyA addition signal, a selection marker, SV
Forty replication origins and the like can be added. Further, if necessary, the protein encoded by the DNA of the present invention can be expressed as a fusion protein with another protein (eg, glutathione S-transferase and protein A). Such a fusion protein can be cleaved using a protease of the applicable name and separated into respective proteins.

As the host cell, for example, Escherichia, Bacillus, yeast, insect cells, insects, animal cells and the like are used. Specific examples of Escherichia bacteria include Escherichia coli K12.
DH1 (Proc. Natl. Acad. Sci. USA, 60, 1
60 (1968)), JM103 (Nucleic Acids Resear)
ch, 9, 309 (1981)), JA221 (Journal
of Molecular Biology, 120, 517 (197
8)), and HB101 (Journal of Molecular Biolog
y, Vol. 41, 459 (1969)). Examples of Bacillus bacteria include, for example, Bacillus subtilis (Baci
llus subtilis) MI114 (Gene, 24, 255 (1
983)), 207-21 [Journal of Biochemistry,
95, 87 (1984)]. Examples of yeast include Saccharomyces cerevisiae (Saccaromy)
ces cerevisiae) AH22, AH22R-, NA87-
11A, DKD-5D, 20B-12, Schizosaccaromyces pombe NCYC
1913, NCYC2036, Saccharomyces pichia pastoris and the like. As animal cells, for example, monkey cells COS
-7, Vero, Chinese hamster cells CHO (hereinafter abbreviated as CHO cells), dhfr gene-deficient CHO cells, mouse L cells, mouse AtT-20, mouse myeloma cells, rat GH3, human FL cells, and the like.

Transformation of these host cells can be performed according to methods known in the art. For example, the following documents can be referred to. Proc. Natl.
Acad. Sci. USA, 69, 2110 (1972); Ge
ne, 17, 107 (1982); Molecular & General
Genetics, 168, 111 (1979); Methods in
Enzymology, 194, 182-187 (1991);
Proc. Natl. Acad. Sci. USA), 75, 1929.
(1978); Cell Engineering Separate Volume 8, New Cell Engineering Experiment Protocol. 263-267 (1995) (published by Shujunsha); and Virology, 52, 456 (1973).

The thus obtained transformant transformed with the expression vector containing the DNA of the present invention or a gene containing the DNA of the present invention can be cultured according to a method known in the art. For example, the following documents can be referred to. For example, when the host is a bacterium belonging to the genus Escherichia, culturing is usually performed at about 15 to 43 ° C. for about 3 to 3 hours.
It is performed for 24 hours, and if necessary, ventilation and stirring can be added. When the host is a bacterium belonging to the genus Bacillus, the cultivation is usually carried out at about 30 to 40 ° C. for about 6 to 24 hours, and if necessary, aeration and stirring can be applied. When culturing a transformant in which the host is yeast, culturing is usually performed at about 20 ° C. to 35 ° C. for about 24 to 72 hours using a medium adjusted to a pH of about 5 to 8, if necessary, by aeration or the like. Stirring can also be added. When culturing a transformant whose animal host is an animal cell, p
H is usually about 30 ° C. using a medium adjusted to about 6 to 8.
The reaction is carried out at ４０40 ° C. for about 15 to 60 hours, and aeration and stirring can be added as necessary.

In order to separate and purify the polypeptide or protein of the present invention from the above-mentioned culture, for example, after culturing, cells or cells are collected by a known method, suspended in an appropriate buffer, sonicated, lysozyme After disrupting the cells or cells by freeze-thawing or the like, a crude extract of the protein is obtained by centrifugation or filtration. In a buffer solution, a protein denaturant such as urea or guanidine hydrochloride, or Triton X-1
00 ^TM surfactant may be included, such as. When the protein is secreted into the culture solution, after the culture is completed, the supernatant is separated from the cells or cells by a known method, and the supernatant is collected. The protein contained in the thus obtained culture supernatant or extract can be purified by appropriately combining known separation and purification methods. The thus obtained polypeptide (protein) of the present invention can be converted to a salt by a known method or a method analogous thereto,
Conversely, when it is obtained as a salt, it can be converted into a free form or another salt by a known method or a method analogous thereto. Furthermore, before or after purification of the protein produced by the recombinant, an appropriate protein modification enzyme such as trypsin and chymotrypsin is allowed to act on the protein to optionally modify it or partially remove the polypeptide. Can also. The presence of the polypeptide (protein) of the present invention or a salt thereof can be measured by various binding assays, enzyme immunoassays using specific antibodies, and the like.

The polypeptide (protein) of the present invention has a C-terminal
Is usually a carboxyl group (-COOH) or
Rate (-COO-), but the C-terminal is an amide (-COO-).
NH _Two) Or an ester (—COOR)
No. Here, as R in the ester, for example, methyl
, Ethyl, n-propyl, isopropyl or n-
C1-6 alkyl group such as butyl, for example, cyclopentene
C3-8 cycloalkyl groups such as cyclohexyl and cyclohexyl, examples
For example, C6-12 aryl such as phenyl and α-naphthyl
Groups, for example phenyl-C such as benzyl, phenethyl, etc.
1-2 alkyl group or α- such as α-naphthylmethyl
C7-14 aralkyl groups such as naphthyl-C1-2 alkyl groups
In addition, pivaloylo, commonly used as an oral ester
Xymethyl esters and the like are used.

When the polypeptide (protein) of the present invention has a carboxyl group (or carboxylate) at a position other than the C-terminus, a protein in which the carboxyl group is amidated or esterified is also included in the protein of the present invention. As the ester in this case, for example, the above-mentioned C-terminal ester and the like are used. Further, the protein of the present invention includes N
When the amino group of the terminal methionine residue is protected by a protecting group (for example, a C1-6 acyl group such as a formyl group or an acetyl group), the N-terminal glutamic acid residue formed by cleavage in vivo is Pyroglutamate, on the side chain of an amino acid in the molecule, such as OH, COOH,
Includes those in which NH ₂ , SH, etc. are protected with an appropriate protecting group (eg, C 1-6 acyl group such as formyl group, acetyl group, etc.), and complex proteins such as so-called glycoproteins having sugar chains bonded thereto. It is.

The partial polypeptide of the protein of the present invention may be any partial polypeptide of the above-described polypeptide (protein) of the present invention, as long as it has substantially the same activity. For example, at least 10 or more, preferably 50 or more, more preferably 70 or more, more preferably 100 or more, and most preferably 2 or more of the constituent amino acid sequences of the polypeptide (protein) of the present invention.
For example, a peptide having an amino acid sequence of 00 or more and having a biological activity substantially the same as the function of the polypeptide of the present invention or the like is used. As the partial polypeptide of the present invention, for example, those containing each functional domain are preferable. Although partial peptide C-terminal of the present invention is usually a carboxyl group (-COOH) or carboxylate (-COO-), as the protein of the present invention described above, C-terminal amide (-CONH ₂₎ or ester (-COOR). Further, similar to the above-mentioned protein of the present invention, the partial peptide of the present invention includes a peptide in which the amino group of the N-terminal methionine residue is protected with a protecting group, and a glutamyl formed by cleavage of the N-terminal side in vivo. Those in which the group is pyroglutamine-oxidized, those in which the substituent on the side chain of the amino acid in the molecule is protected with an appropriate protecting group,
Alternatively, a complex peptide such as a so-called glycopeptide having a sugar chain bonded thereto is also included. The partial peptide of the present invention can be used, for example, as a reagent, a standard substance for experiments, or an immunogen or a part thereof.

The salt of the polypeptide (protein) of the present invention or a partial peptide thereof is preferably a physiologically acceptable acid addition salt. Such salts include, for example,
Salts with inorganic acids (eg, hydrochloric acid, phosphoric acid, hydrobromic acid, sulfuric acid) or organic acids (eg, acetic acid, formic acid, propionic acid, fumaric acid, maleic acid, succinic acid, tartaric acid, citric acid, malic acid) , Oxalic acid, benzoic acid, methanesulfonic acid,
For example, a salt with benzenesulfonic acid) is used.

The polypeptide (protein) of the present invention, its partial peptide, a salt thereof, or an amide thereof can also be prepared by a chemical synthesis method known in the art. For example, using a commercially available resin for protein synthesis, an amino acid appropriately protected with an α-amino group and a side chain functional group may be subjected to various condensation methods known per se in the art according to the sequence of the target protein. , On a resin. At the end of the reaction, the protein is cleaved from the resin, and at the same time, various protecting groups are removed.In addition, an intramolecular disulfide bond formation reaction is carried out in a highly diluted solution to obtain the desired protein,
Obtain the partial peptides or their amides.
For the condensation of the protected amino acids described above, for example, DC
C, N, N'-diisopropylcarbodiimide, and N-ethyl
Various activating reagents such as -N '-(3-dimethylaminoprolyl) carbodiimide that can be used for protein synthesis represented by carbodiimides can be used. Activation by these includes racemization inhibiting additives (eg, HOBt, HOOB
The protected amino acid may be directly added to the resin together with t), or may be added to the resin after activating the protected amino acid in advance as a symmetric acid anhydride or HOBt ester or HOOBt ester.

Solvents used for activation of protected amino acids and condensation with resins include acid amides, halogenated hydrocarbons, alcohols, sulfoxides, and ethers, which are used in the art for protein condensation reactions. It can be appropriately selected from known solvents. The reaction temperature is appropriately selected from the range that can be used for the protein bond formation reaction. The activated amino acid derivative is usually used in a 1.5 to 4-fold excess. As a result of the test using the ninhydrin reaction, if the condensation is insufficient, sufficient condensation can be performed by repeating the condensation reaction without removing the protecting group. When sufficient condensation cannot be obtained even by repeating the reaction, the unreacted amino acid can be acetylated using acetic anhydride or acetylimidazole so as not to affect the subsequent reaction. As a protecting group such as each amino group, carboxyl group and serine hydroxyl group of the raw material, a group usually used in the technical field can be used. The protection of the functional group which should not be involved in the reaction of the raw materials, the protecting group, the elimination of the protective group, the activation of the functional group involved in the reaction, and the like can be appropriately selected from known groups or known means.

The partial peptide of the present invention or a salt thereof can be produced according to a peptide synthesis method known per se in the art, or by cleaving the protein of the present invention with an appropriate peptidase. As a method for synthesizing a peptide, for example, any of a solid phase synthesis method and a liquid phase synthesis method may be used. Examples of the known condensation method and elimination of the protecting group include the methods described in the following (1) to (3). (1) Nobuo Izumiya et al., Fundamentals and Experiments of Peptide Synthesis, Maruzen Co., Ltd. (1975) (2) Haruaki Yajima and Shunpei Sakakibara, Biochemistry Laboratory 1, Protein Chemistry I
V, 205, (1977) (3) Supervised by Haruaki Yajima, Development of Continuing Drugs Volume 14 Peptide Synthesis Purification after the reaction at Hirokawa Shoten is also known per se, for example, solvent extraction, distillation, column chromatography, liquid chromatography The partial peptide of the present invention can be purified and isolated by a combination of lithography and recrystallization. When the partial peptide obtained by the above method is in a free form, it can be converted to an appropriate salt by a known method. Can be.

Antibodies against the polypeptide (protein) of the present invention, its partial peptide, or a salt thereof may be any of a polyclonal antibody and a monoclonal antibody as long as they can recognize them. Antibodies against the polypeptide (protein) of the present invention, its partial peptide or a salt thereof can be produced by using the polypeptide (protein) of the present invention or its partial peptide as an antigen according to a known method for producing an antibody or antiserum. . The antibody of the present invention can be used for detecting the polypeptide (protein) of the present invention or the like present in a subject such as a body fluid or a tissue. In addition, preparation of an antibody column used for purifying them, detection of the polypeptide of the present invention (protein) in each fraction during purification, analysis of the behavior of the polypeptide of the present invention (protein) in test cells, etc. Can be used for

Furthermore, the antibody of the present invention can be determined by known methods such as quantification of the polypeptide (protein) of the present invention in a test solution, in particular, quantification by a sandwich immunoassay using a monoclonal antibody, and tissue staining. It can be used for detection and the like. Thereby, for example, a disease associated with the polypeptide (protein) of the present invention or the like can be diagnosed. For these purposes, the antibody molecule itself may be used, and F (ab ') 2, Fab',
Alternatively, the Fab fraction may be used. The method for quantifying the protein or the like of the present invention using the antibody of the present invention is not particularly limited, and may be an antibody, an antigen, or an antibody-antigen complex corresponding to the amount of antigen (eg, the amount of protein) in the test solution. Any method may be used as long as it is a method for detecting the amount of by chemical or physical means and calculating the amount from a standard curve prepared using a standard solution containing a known amount of antigen. For example, nephelometry, a competitive method, an immunometric method, and a sandwich method are suitably used, but it is preferable to use a sandwich method described later in terms of sensitivity and specificity. As a labeling agent used in a measurement method using a labeling substance, for example, a radioisotope, an enzyme, a fluorescent substance, a luminescent substance, and the like known in the art can be used.

For details of general technical means relating to these measurement / detection methods, a review, a textbook, and the like can be referred to. For example, edited by Hiro Irie, “Radio Immunoassay” (Kodansha, published in 1979), Eiji Ishikawa et al., “Enzyme Immunoassay” (3rd edition) (Medical Publishing, published in 1987), “Methods in ENZYMOLOGY” Vol. .70 (Immunoche
mical Techniques (Part A)), ibid.Vol. 73 (Immunoche
mical Techniques (Part B)), Ibid.Vol. 74 (Immunochem
ical Techniques (Part C)), ibid.Vol. 84 (Immunochem
ical Techniques (Part D: Selected Immunoassays)),
Ibid.Vol. 92 (Immunochemical Techniques (Part E: Mono
clonal Antibodies and General Immunoassay Method
s)), ibid.Vol. 121 (Immunochemical Techniques (Part
I: HybridomaTechnology and Monoclonal Antibodies))
(Above, published by Academic Press).

An antisense oligonucleotide (D) having a base sequence substantially complementary to the DNA encoding the polypeptide (protein) of the present invention or a partial polypeptide thereof
NA) may be any antisense DNA as long as it has a base sequence substantially complementary to the base sequence of the DNA and has an action capable of suppressing the expression of the DNA. The substantially complementary base sequence is, for example, preferably about 90 or more, more preferably about 95% or more, and most preferably 100% or more of the entire base sequence or a partial base sequence of the base sequence complementary to the DNA of the present invention. And the like. Nucleic acid sequences (modified RNA or DNA) having the same action as these antisense DNAs are also included in the antisense DNA referred to in the present invention. These antisense DNAs are known DNases.
It can be manufactured using an A synthesizer or the like.

Furthermore, the polypeptide (protein) of the present invention is useful as a reagent for screening compounds that specifically interact with these substances. That is, the present invention uses a polypeptide (protein) of the present invention, a partial peptide thereof or a salt thereof, or an antibody against the same, and screens for a compound that specifically interacts with the substance or a salt thereof. Methods and screening kits therefor are provided. The compound identified by using the screening method or the screening kit of the present invention or a salt thereof is a compound selected from the test compounds described above, interacts with the polypeptide (protein) of the present invention and the like, Modulate, inhibit,
It is a compound that promotes or antagonizes. The compound or a salt thereof may directly act on the activity of the protein or the like of the present invention, or may indirectly act on the expression of the polypeptide (protein) of the present invention or the like to inactivate the polypeptide or the protein of the present invention (protein). ) And the like. As the salt of the compound, for example, a pharmaceutically acceptable salt or the like is used. Examples include salts with inorganic bases, salts with organic bases, salts with inorganic acids, salts with organic acids, salts with basic or acidic amino acids, and the like. Compounds that inhibit biological activities such as the polypeptides (proteins) of the present invention may also be used as medicaments such as therapeutic / prophylactic agents for the above various diseases.

By using the DNA of the present invention and a gene containing the DNA as a probe, DNA or mR encoding the polypeptide of the present invention or a partial peptide thereof can be obtained.
Since an abnormality of NA (gene abnormality) can be detected, it is useful as a gene diagnostic agent for, for example, damage, mutation or decreased expression of the DNA or mRNA, and increased or excessive expression of the DNA or mRNA.
The genetic diagnosis using the DNA of the present invention includes, for example,
Known Northern hybridization and PCR-SS
CP method (Genomics, Vol. 5, pp. 874-879 (198
9 years), Proceedings of the National Academy of Sci
ences of the United States of America, Vol. 86,
2766-2770 (1989)). Further, when the DNA or gene of the present invention is abnormal or defective, or when the expression level is reduced, patients who cannot exhibit normal functions in vivo can be treated according to the known means (1) The DNA or gene of the present invention is introduced and expressed in the patient by gene therapy using a suitable vector such as a viral vector, an adenovirus vector, an adenovirus associated virus vector as a vehicle, or (2) the present invention. By injecting the protein or the like into the patient, it is considered that the function of the protein or the like of the present invention can be exhibited in the patient. The DNA or gene of the present invention can be administered by a gene gun or a catheter such as a hydrogel catheter, using the DNA alone or together with an auxiliary agent for promoting uptake.

In the present specification and drawings, when bases, amino acids and the like are represented by abbreviations, IUPAC-IUB C
abbreviation by ommision on Biochemical Nomenclature or common abbreviation in the field,
When an amino acid can have an optical isomer, the L-form is indicated unless otherwise specified.

[0034]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the invention is limited thereto. Note that various genetic manipulations in the Examples
rrent protocols in molecular biology (edited by Fr
ederick M. Ausubel et al., 1987).

(1) Construction of cDNA libraries derived from human adult whole brain, human adult hippocampus and human fetal whole brain Oligonucleotides having a NotI site (GACTAGTTCT
AGATCGCGAGCGGCCGCCC (T) ₁₅ )
Double-stranded cDNA was synthesized with SuperScript II reverse transcriptase kit (Gibco BRL) using mRNA from human adult whole brain, human adult hippocampus and human fetal whole brain (Clontech) as a template with (Gibco BRL) as a primer. . S
An adapter having an all site (Gibco BRL)
Ligation with DNA. Thereafter, NotI digestion was carried out, and low-melting agarose electrophoresis at a concentration of 1% was performed.
The DNA fragment b or more was purified. Purified cDNA fragment
PBluescript IISK treated with SalI-NotI restriction enzyme
+ Ligation with plasmid. E. coli ElectroM
This recombinant plasmid was introduced into ax DH10B strain (Gibco BRL) by electroporation.

(2) Screening Next, clones were randomly picked from the thus constructed cDNA library and spotted on a membrane. Next, each 3 'end of a mixture of oligo DNAs (21 bases each) prepared based on the nucleotide sequences of about 1,300 clones whose full length has already been analyzed by the present inventors has been subjected to terminal transferase. DIG label,
Dot hybridization using these as probes (Current protocols in molecular biology)
(Edited by Frederick M. Ausubel et al., 1987)
As a result, duplicate clones (repeated clones) were removed. Next, in vitro transcription and translation (Promega TN
T T7 Quick Coupled Transcription / Translation Syste
L1107), and a clone in which a product of 50 kDa or more was recognized was selected. Next, the terminal nucleotide sequence of the selected clone was determined, and the obtained sequence was used as a query to search for the homology search program BLASTN 2.0.14 (Altschul, Stephen
F., Thomas L. Madden, Alejandro A. Schaffer, Jing
hui Zhang, Zheng Zhang, Webb Miller, and David J. L
ipman (1997), "Gapped BLAST and PSI-BLAST: a new g
eneration of protein database search programs ", N
ucleic Acids Res. 25: 3389-3402) using nr (All Ge
nBank + EMBL + DDBJ + PDB sequences (but no EST, STS, GS
S, orphase 0,1 or 2 HTGS sequences)) A homology search was performed on the database. As a result, the entire nucleotide sequence was determined for the case where no homologous gene was present, that is, for the case of a novel gene. For sequencing, a DNA sequencer manufactured by PE Applied Biosystems (ABI PRIS
M377) and its reaction kit. Most sequences were determined from shotgun clones using the dye terminator method. For some base sequences, oligonucleotides were synthesized based on the determined base sequence and determined by the primer walking method.

Thus, screening of a novel DNA or gene was performed. As a result, a novel DNA or gene shown in any one of SEQ ID NOs: 1 to 63 (excluding 52) in the sequence listing was detected. The nucleotide sequence of these novel DNAs or genes was determined by the above-described sequencing method. The names of the clones having the DNA or gene of the present invention are shown in Tables 1 to 3.

(3) Search for homology of the DNA of the present invention Next, based on the total nucleotide sequence thus obtained, the amino acid sequence of the clone was analyzed against the known sequence library nr release 121 using the analysis program BLASTP 2.0.14 (Altschul, Stephen F.,
Thomas L. Madden, Alejandro A. Schaffer, Jinghui
Zhang, Zheng Zhang, Webb Miller, and David J. Lipma
n (1997), "Gapped BLAST and PSI-BLAST: a new genera
tion of protein database search programs ", Nuclei
c Acids Res. 25: 3389-3402), which revealed homology with each homologous gene shown in Tables 4 to 8. Tables 4 to 8 list information on these homologous genes, that is, their names, database IDs, species, protein lengths, and references. or,
The meaning of the abbreviation of “organism species” in each of these tables is explained in Table 9.

Further, the DNA of the present invention contained in each clone
Alternatively, various data on the homology between the gene and each homologous gene shown in Tables 4 to 8 are summarized in Tables 10 to 12. The meaning of each item in these tables is as follows. "Clone from" Origin of homologous region of clone "Clone to"
End point of homologous region of clone "Homologous gene from" Origin of homologous region of homologous gene "Homologous gene to" End point of homologous region of homologous gene "Score" The higher the value, the higher the reliability "E-value" The closer the value is to 0, the higher the reliability is. "Homology" Ratio of amino acid residue matching in homologous region "Homologous range ratio" Percentage of homologous region in homologous gene

(4) Search for various domains Next, the amino acid sequence encoded by the DNA contained in the clone was used as a query, and the search tool Pfam HMM ver 2.1 included in Pfam 5.2 was used.
Search (HMMPFAM) (Sonnhammer ELL, Eddy SR, Birney
E, Bateman A, Durbin R (1998) Pfam: multiple sequ
ence alignments and HMM-profiles of protein domain
s, Nucleic Acids Research 26: 320-322). Furthermore, the SOSUI system (ver. 1.0 / 10, Mar., 1996), a membrane protein prediction program (Takats
ugu Hirokawa, Seah Boon-Chieng and Shigeki Mitaku,
SOSUI: Classification and Secondary Structure Pre
diction System for Membrane Proteins, Bioinformati
cs (formerly CABIOS) 1998 May; 14 (4): 378-379.). These detected functional domains and transmembrane domains are shown in Tables 13 to 20 for each clone. The meaning of each item in these tables is as follows. "Function domain" Pfam SOSUI
Origin of functional domain "Clone from" Origin of functional domain "Clone to" End point of functional domain "Homologous gene from" Origin of functional domain "Homologous gene to"
Functional domain end point "Score (Pfam only)" The higher this value is, the more reliable "Exp (Pfam only)" This value is 0
Table 21 shows the complete notation of each functional domain.

(5) Expression site The expression at the tissue and brain sites using RT-PCR ELISA was shown in Tables 22 and 23, which showed the strongest expression in each case. Table 24 shows the complete notation of the tissue and brain site. (6) Using the DNA acid sequence of the chromosome position clone as crelie, the analysis program BLASTN 2.0.14 (Altschul, Stephen) was used for the human genomic sequence corresponding to the known sequence library Genbank release119.
F., Thomas L. Madden, Alejandro A. Schaffer, Jing
hui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new
generation of protein database search programs ",
NucleicAcids Res. 25: 3389-3402).
The description of the number of the chromosome from which this clone was derived was extracted from the description (Definition) of the matched clone, and is shown in Tables 22 to 23.

Based on the above information on homology, homologous genes, various domains, expression sites, chromosome positions, etc., those skilled in the art can list the DNA or gene of the present invention in Tables 1 to 3. It can be predicted that each function is provided. The full length of the genes contained in the following clones was determined for the following reasons. bf00027:
Alignment with human neuronal interleukin-16 suggests its full length. bf00083: Alignment with precursor of bovine pyruvate dehydrogenase phosphatase is considered to be the full length of human pyruvate dehydrogenase phosphatase precursor.
bh00052: TSC22-related inducible leucine zipper in mice
Alignment with 1b suggests the full length of human TSC22-related inducible leucine zipper 1b.

The novel DNA or gene obtained in the present invention is accumulated on a so-called DNA chip or the like, and is collected from, for example, blood or tissue of a normal patient as a control and a patient having a brain-related disease such as mental illness. Hybridization of the prepared probe can be useful for diagnosis, treatment and the like of these diseases. In addition, PCR is performed using chromosomal DNA extracted from human blood or tissue using a synthetic DNA primer prepared based on the DNA or gene of the present invention or a partial base sequence thereof, and the base sequence of the product is determined. By determining, the DNA of the present invention
Or a single base mutation that varies by individual in the gene,
That is, cSNIPs can be found. As a result, the constitution and the like of the individual are predicted, and the development of a medicine suitable for each individual becomes possible. In addition, an ortholog (homolog, counterpart) gene for the DNA or gene of the present invention in a model organism such as a mouse is isolated by cross-hybridization, and for example, a human disease model animal is prepared by knocking out these genes, It is also possible to search for and identify genes that cause human pathogenesis. Furthermore, antibodies to the DNA or gene of the present invention are comprehensively prepared, and they are integrated to form a so-called PROT.
By preparing an EIN chip and detecting a difference in the protein expression level between a patient and a normal person, it can be used for diagnosis and treatment of a disease from proteome analysis.

[0044]

[Table 1]

[0045]

[Table 2]

[0046]

[Table 3]

[0047]

[Table 4]

[0048]

[Table 5]

[0049]

[Table 6]

[0050]

[Table 7]

[0051]

[Table 8]

[0052]

[Table 9]

[0053]

[Table 10]

[0054]

[Table 11]

[0055]

[Table 12]

[0056]

[Table 13]

[0057]

[Table 14]

[0058]

[Table 15]

[0059]

[Table 16]

[0060]

[Table 17]

[0061]

[Table 18]

[0062]

[Table 19]

[0063]

[Table 20]

[0064]

[Table 21]

[0065]

[Table 22]

[0066]

[Table 23]

[0067]

[Table 24]

[0068]

[Sequence List] SEQUENCE LISTING <110> Kazusa DNA Research Institute <120> Novel Genes and Proteins Encoded by the Genes <130> AB02008 <160> 62 <170> PatentIn Ver. 2.1 <210> 1 <211> 7819 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (669) .. (2558) <400> 1 aaagcagttg gcacgggcgg cccaccttgg agaaggaacg agagaagaac tcagcacccc 60 cgcatcgcag ggctcagaag gtcatgatcc gctccagcag tgacagcagc tacatgtctg 120 ggtccccagg gggaagtcct gggagtggca gtgctgagaa gccgtcctct gacgtggaca 180 tcagcacaca cagccccagc ttgcctctgg cacgggagcc agtggtgctt tctatagcat 240 cctccaggct gccccaggag agcccacccc tcccagagag ccgggacagc cacccgccgc 300 tgagactgaa gaaatccttt gagattttgg tgagaaagcc tatgtcctcc aagcccaagc 360 ctccacccag aaaatacttt aaaagtgaca gtgaccctca gaagagtctg gaagagagag 420 agaactcctc atgctcttct gggcacaccc cacccacctg tggccaggaa gcgagagagc 480 tgctgccact gctgctacca caggaagaca cagcagggag aagccctagt gcctctgccg 540 gctgcccagg acctggtatc ggcccacaga ccaagtcctc cacagagggc gagccagggt 600 ggagaagagc cagcccagtg acccaaacat ccccgataaa acacccactg cttaagaggc 660 aggctcgg atg gac tat agc ttt gat acc aca gcc gaa gac cct tgg gtt 710 Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val 1 5 10 agg att tct gac tgc atc aaa aac tta ttt agc ccc atc atg agt gag 758 Arg Ile Ser Asp Cys Il e Lys Asn Leu Phe Ser Pro Ile Met Ser Glu 15 20 25 30 aac cat ggc cac atg cct cta cag ccc aat gcc agc ctg aat gaa gaa 806 Asn His Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu 35 40 45 gaa ggg aca cag ggc cac cca gat ggg acc cca cca aag ctg gac acc 854 Glu Gly Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr 50 55 60 gcc aat ggc act ccc aaa gtt tac aag tca gca gac agc agc act gtg 902 Ala Asn Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val 65 70 75 aag aaa ggt cct cct gtg gct ccc aag cca gcc tgg ttt cgc caa agc 950 Lys Lys Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser 80 85 90 ttg aaa ggt ttg agg aat cgt gct tca gac cca aga ggg ctc cct gat 998 Leu Lys Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp 95 100 105 110 cct gcc ttg tcc acc cag cca gca cct gct tcc agg gag cac cta gga 1046 Pro Ala Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly 115 120 125 tca cac atc cgg gcc tcc tcc tcc tcc tcc tcc atc agg cag aga atc 1094 Ser His Ile Arg Ala S er Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile 130 135 140 agc tcc ttt gaa acc ttt ggc tcc tct caa ctg cct gac aaa gga gcc 1142 Ser Ser Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala 145 150 155 cag aga ctg agc ctc cag ccc tcc tct ggg gag gca gca aaa cct ctt 1190 Gln Arg Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu 160 165 170 ggg aag cat gag gaa gga cgg ttt tct gga ctc ttg gga ggg gct 1238 Gly Lys His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala 175 180 185 190 gca ccc act ctt gtg ccc cag cag cct gag caa gta ctg tcc tcg ggg 1286 Ala Pro Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly 195 200 205 tcc cct gca gcc tcc gag gcc aga gac cca ggt gtg tct gag tcc cct 1334 Ser Pro Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro 210 215 220 ccc cca ggg cgg cag ccc aat cag aaa act ctc ccc cct ggc ccg gac 1382 Pro Pro Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp 225 230 235 ccg ctc cta agg ctg ctg tca aca cag gct gag gaa tct caa ggc cca 1430 Pr o Leu Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro 240 245 250 gtg ctc aag atg cct agc cag cga gca cgg agc ttc ccc ctg acc agg 1478 Val Leu Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg 255 260 265 270 tcc cag tcc tgt gag acg aag cta ctt gac gaa aag acc agc aaa ctc 1526 Ser Gln Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu 275 280 285 285 tat tct atc agc agc caa gtgca tcg gct gtc atg aaa tcc ttg ctg 1574 Tyr Ser Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu 290 295 300 tgc ctt cca tct tct atc tcc tgt gcc cag act ccc tgc atc ccc aag 1622 Cys Leu Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys 305 310 315 gaa ggg gca tct cca aca tca tca tcc aac gaa gac tca gct gca aat 1670 Glu Gly Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn 320 325 330 ggt tct gct gaa aca tct gcc ttg gac aca ggg ttc tcg ctc aac ctt 1718 Gly Ser Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu 335 340 345 350 tca gag ctg aga gaa tat aca gag ggt ctc ac gcc aag gaa gac 1766 Ser Glu Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp 355 360 365 gat gat ggg gac cac agt tcc ctt cag tct ggt cag tcc gtt atc tcc 1814 Asp Asp Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser 370 375 380 ctg ctg agc tca gaa gaa tta aaa aaa ctc atc gag gag gtg aag gtt 1862 Leu Leu Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val 385 390 395 ctg gat ga aca tta aag caa tta gac ggc atc cat gtc acc atc 1910 Leu Asp Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile 400 405 410 tta cac aag gag gaa ggt gct ggt ctt ggg ttc agc ttg gca gga gga 1958 Leu His Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly 415 420 425 430 gca gat cta gaa aac aag gtg att acg gtt cac aga gtg ttt cca aat 2006 Ala Asp Leu Glu Asn Lys Val Ile Thr Val Val Arg Val Phe Pro Asn 435 440 445 ggg ctg gcc tcc cag gaa ggg act att cag aag ggc aat gag gtt ctt 2054 Gly Leu Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu 450 455 460 tcc atc aac ggc aag tct ctc a ag ggg acc acg cac cat gat gcc ttg 2102 Ser Ile Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu 465 470 475 gcc atc ctc cgc caa gct cga gag ccc agg caa gct gtg att gtc aca 2150 Ala Ile Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr 480 485 490 agg aag ctg act cca gag gcc atg ccc gac ctc aac tcc tcc act gac 2198 Arg Lys Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp 495 500 505 510 tct gca gcc tca gcc tct gca gcc agt gat gtt tct gta gaa tct aca 2246 Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 515 520 525 gag gcc aca gtc tgc acg gtg aca ctg gag aag atg tcg gca ggg ctg 2294 Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu 530 535 540 ggc ttc agc ctg gaa gga ggg aag ggc tcc cta cac gga gac aag cct 2342 Gly Phe Ser Leu Glu Gly Gly Ser Leu His Gly Asp Lys Pro 545 550 555 ctc acc att aac agg att ttc aaa gga gca gcc tca gaa caa agt gag 2390 Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu 560 565 570 aca gtc c ag cct gga gat gaa atc ttg cag ctg ggt ggc act gcc atg 2438 Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met 575 580 585 585 590 cag ggc ctc aca cgg ttt gaa gcc tgg aac atc atgag cct 2486 Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro 595 600 605 gat gga cct gtc acg att gtc atc agg aga aaa agc ctc cag tcc aag 2534 Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys 610 615 620 gaa acc aca gct gct gga gac tcc taggcaggac atgctgaagc caaagccaat 2588 Glu Thr Thr Ala Ala Gly Asp Ser 625 630 aacacacagc taacacacag ctcccataac cgctgattct cagggtctct gctgccgccc 2648 cacccagatg ggggaaagca caggtgggct tcccagtggc tgctgcccag gcccagacct 2708 tctaggacgc cacccagcaa aaggttgttc ctaaaataag ggcagagtca cacgggggca 2768 gctgatacaa attgcagact gtgtaaaaag agagcttaat gataatattg tggtgccaca 2828 aataaaatgg atttattaga atttcatatg acattcatgc ctggcttcgc aaaatgtttc 2888 aagtactgta actgtgtcat gattcacccc caaacagtg gcatcattgat ggtcatgat gg ctcatctct gtcccacttg gcatcagctg 3008 gcgtcatgca aagtcatgca aaggctggga ccacgtgaga tcattcactc atacatctgg 3068 ccgttgatgt tggctgggaa ctcacctggg gctgctggcc tgaatgctta taggtggcct 3128 ctccttgtgg cctgggcctc ctcacaacat ggtgtctgga ttcccaggat gagcatccca 3188 ggatcgcaag agccatgtag aagctgcatc ttgtttatac ctttgccttg gaagttgcat 3248 ggcatcacct ccaccatact ccatcagtta gagctgacac aaacctgcct gggtttaagg 3308 ggagaggaaa tattgctggg gtcatttatg aaaaatacag tttgtcacat gaaacatttg 3368 caaaattgtt tttggttgga ttggagaagt aatcctaggg aagggtggtg gagccagtaa 3428 acagaggagt acaggtgaag caccaagctc aaagcgtgga caggtgtgcc gacagaagga 3488 accagcgtgt atatgagggt atcaaataaa attgctacta cttacctacc acatgccaag 3548 cactgtgctc agggctaaac gggcattgcc tttagtgatc acagcagctt ctacggtgta 3608 tggttctgtg ccaatgtatt gataagaggg cacacactgt gtacagtaaa tggcttatcc 3668 agctggtgag tgatgcggca gattgagttt tcttctgtga ttcggtggag actatcagcc 3728 caagatgctt taagtgcaca acattacagg gaatgcctga gtgcctggcc aaagggatat 3788 ttggtttggc catctctgga tgcctgattg ccaagct cag gaccaggcaa tgtgactttg 3848 catcagcaac aaccagcatc ccttgaccag gcctgggcca gagtattggt ctcctctcag 3908 cccctgatcc tgtgaagtaa ggatgtgggg gaagacctgg caaggacaca gatgaaacac 3968 aaacaatagt aattctcagg ccatcatcag tggagccatg ttaatgtaat ctgatggctt 4028 ctccagggtc cacaggaagt gaagaatctg tttcccagca gtggactcaa aacccatctg 4088 ggctcctaac cttcctgtaa acccctttag tggcttcatt agagcaggcg ttcagctcac 4148 tgttctattc atctcaagga ataatgggct tagagcagtt tctgtcctgc tggttaactt 4208 gtttggccta ttccattctg gattttgtca agcagtagac aagcaattag acaagaactt 4268 ggaggcacca tttgtatcca ctttttagac ttaatagaaa cattgaagat gaacataatc 4328 taccaacgaa agacgtgatt caattcaaca ctcccttccc atgacccagg ctgggcaagg 4388 aggccacgtg atgtggaggg cacattcctt gcctgcacaa actcaccatc tgtgcacgca 4448 gtggccttcc ctaaaatcag ggaattgttt taagtcttat caagcagcca agggatgaaa 4508 gagaaggtgg gttttcatca agactggaag gtggggacag ggatgagcat ggagctggcc 4568 gtgggcctgg ggtaccaaga gactccttga gagaccaggc aaagcaagtg attgggacag 4628 aggttatctg tcccaggtta tctgggcata gatgcaggtg a gcccatggc cctcccagta 4688 cctcctgtct ctggcctgtt ttagaaggtt ctctcctccc caaggagaca caacaactcc 4748 tagggccact gaagatataa ctattgccca ggtttctggt ctctaggctg gggaagtcct 4808 ctgggtagga atcagcaaga agatcctaaa acaaaagctc atccatttgc gttccatgat 4868 gctgggattt acacttgagg cttagctttg ctctgccaac ttcttcagag ctgacacagg 4928 atgaaggcaa tgccatcctc aaacactgca ggcatcacag ctaacaattg tgaagtcgtc 4988 ttaactcacc ataaaaagga atccactccc aggcagccct acttctttgc tttgcccagc 5048 attttactga ttcatacatt atctcacttg tgccaacact caagaagcag gctacactga 5108 cactggtatt cctgcctcca tattttcttt aaaagacaaa tcaaagcaga tatattaagt 5168 gactgttcaa gagcacactt ggcccaagtg gcagagcttg gactggatgc atgttttcca 5228 gctcctcatc cagggctctg accagtttaa cctgatgcag tcacgtggag gagcagtgca 5288 ggcacagtat gtcccatagg cccagtgaga tgcattcttg gttggctggc cttccacttg 5348 gctacacagg gatgtacaag gcgatcccat cttgataaga ccaccacctc agagtatgga 5408 gctcagagag ggcaggcatg aagtttcctt ggctggtgca cctagaattg gctgaactca 5468 tgagaagttg atatagaaca gtgcttgcca cagagcgggg actcggt aag cacttaacga 5528 atgaatgaat tctaagtcaa tccaagagtc tgatgatttc ttgaaaaggg tgttagctaa 5588 aggatcttag gcatgactgt agaatttgta gttgcaatag aacagagaaa gaggaagctt 5648 tctgtctcct taacactgag ctgtcatgtt ttaaagcttg ctcacatctt ggcacattta 5708 agagacagtc accccaggac tcaaaaatag ggaagtaaca gtaacgcagg ggaaacgttt 5768 tctgtttgga ggagcaaagg ctgagaacac tgtgaaaaca ttttgcgcgc acaatagtaa 5828 cctgggtaaa tgcagcgtga agggatttta gtcacacgtg gtctttctta caaggaaggt 5888 ggtgggggtg cagatgaggt tgctagagaa tgttagagga tccctctctg gattggagat 5948 agggaaagaa agttgcacgg ctgctgaggc cccttctagg tggcaaggct gtgctccctg 6008 gttctgatga tgtgcctggg tggacatggc ccctgtgagt ttgtacagtc ttgcagcagg 6068 atctagaggg gggatttcca gccagggctg ctagacggag gcctactctt ccatctttcc 6128 tgatggcagg atggcctggc cagggcctgg aagacagaga cctcctgcct ccgcctcagt 6188 aagacgacaa ggaaaggcaa atgcccaagg gaaagaaaag gaaggctctt ctccccagag 6248 ttccccatgc agacatgagt gcgtgctcag ttcagaatca cttctgagaa ctcatcccta 6308 atgctgcaga tttgggctgg aacagattca cactgtctgg tttcaccgag ga catgaaac 6368 tccaccttgc ggggataaag agagaaaaac aaattcatca aatggaagac acattgaaag 6428 tgtttttcct taatgcttat cctgttttta aaccattatt tccaagttga cacctttttt 6488 aaggaaaaat aaatattttg cggcattaaa gccatataca aggtctatat cagaaaaata 6548 tatttggggg gctgcagcac aggactgagg gagcggtaca tgcttaaaag gcaacagggc 6608 ctggttttca gtggcgatga tgattctcta tgacagtcag ggaaacgtgg tctctgagag 6668 tgatgggcac ataaagcctt ggtgccagag tgcatcgcat ggtgtccagg ccgagtctct 6728 gtcagatggt tagaggcctg ggtctaccct gccaggagag gcgtgtttgg gtaacaggca 6788 gatggagttt ggaacacatg aatggctcat cacacgccaa ccctgagtgg ggcaggaggc 6848 aggaagggtg ggctgccgcc tctggttggc attctcagag atgcgcagtc catcagcttg 6908 ttccaaagag tgaacacagg cctctgcgtg ctcccaggct ccttggtgtc ccaacagctg 6968 gagctcctcg atgagtcacg ggagttcttt gccaagaagt aacgatagca ttactcatgg 7028 aattgcttca ctgctttctg aaggttggca taaaaccggg tcatgctgcg ggggaagaag 7088 gagtccacca cgttctgtgg gaggtaaccg ctgaggtcgg tatggaagaa tgtgaccagg 7148 ttggtcttgg tgggttccct gtgaaggcaa cagcagagct gtgttatgat ctgcagca ga 7208 ggtgctgggg acgagcgcca ggcaggtgag cagagcccag cccagtggaa atggccatga 7268 tacagtgatc gcgtctcatc ccttgctgtg ccctccaccc aggagtcctc tctggacctg 7328 ctgattttca ggatggaaac ccatcctgtc ggggatgcat tccacagcct ctcccggcct 7388 ccagggagga agaagtccct actcccagcc caaaaaccca gtaccctgct gcccgattca 7448 ctcagcaaat gctttcagag aactcacttt gtgccaggcc ctgagaggaa cgaagagatg 7508 ctgcccttca ctatttaggg tctgcaacct cctgggggct cctgggaccc tttcaagggg 7568 tctacaaagt taacactatt tttataacaa cacgaacatg tgattcgcct tctctcacat 7628 gcatacagtg gggttttccg gaggttacat gatatgtgat attgcaacag actacacgca 7688 caagcaggta tgagtttctg ttaagcctgg catgaaagag atgggcaaaa atataaaaac 7748 aatgccactc ttttcacagt attttttgtt ttaaaaaaat agtattta gatt <210> 2 <211> 7861 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4317) .. (4637) <400> 2 acaaaatggt gttgacaaag attgttcatt tgtggtctac cagggcataa aattctcaaa 60 aaacataatc agtaggaaac ctctttattc ctgaatatta gagaatatta tatgtcttaa 120 aattattcat gttgaaaagc tctgcctttc atgcatttag gagaaaaagt agagggcagg 180 aggtttatgt agactctggt ctgtgcctga tttggggaat ggaaagactc gacagaagag 240 gccaggtcag ccaagcaggg ctctgttgcg tgcaagatta actgctggtt tgtctttgca 300 gagctccaca cagaacatca tcaaagaact gatggacact tcatctccct gggtgagggg 360 caggtgtacc atgctgtcat ggccattcct gcctcgattg gggtgtgggt gtagagatgg 420 tctctataac cagggcccag acatggctga gaaggccttc tgccaggact ccaccttgat 480 gactcacagg actttgtgcc ttggctttcc ctattgagtg acccacagtt ttaatccaag 540 ggaccctgag tctgtttcct tccttcagcc ccaccatttc accccagcac tgttcaggtg 600 tacaatcggc tttcacatat ttgtaagaat atctaggaaa attatttata ttttactttc 660 acttcatgtt atgaccatga gtgtttttgc atttgctagg gctcattgtt ttaattggcc 720 cccctttatc cctctgtgtg cggaaataaa tcagccctaa atctggatga gacctgcagg 780 tggactccat cagtgcaggc gtggtggggc agcaggagga gcccgtggtg cccaccttcc 840 agagctgcca cc tcttttac ctcctcatgt tccttcctgt gcacctagag agagttcacc 900 cccacccaac agctcctgga cctgctgccc aaaagccaaa aggaactact tcatttgatt 960 tggagactcc aggagcacac actatgtata aacttgagtg cataaggttt gatggagaag 1020 gtggttggaa actgatggtt tacacagcag agcaacatca ctcaactcgt atataagcag 1080 agaaagagtt ggagaaaaat gaaatgaagt gttgagatat cagcacccct tcacttccaa 1140 atggccaaca acctggatcc ttcatctgtg tccacttccc agcaagtcgg aataggtgga 1200 aaagcgagat tgtctttgac catttgctat ggacattgtc agggatggtg cagcctgaat 1260 aagaatgtct gcggtatttc ccgaaataag tatccctcaa ggatgatact gtggacctca 1320 ctcaggaaga atgtgtcctt cagagaaagc tgcacagaga cgtgatgctg gagaagcagt 1380 catctggtta ctttagcatg aatgagagat cctttcgctt cacgtctttg ccagcatttg 1440 gtgttgtcag tgttctagat tttggccatt atagtacatg acttcaggct cctatgtgca 1500 gaagtcctca acccccaggc tgcagaccag tacctgtcca tggcctgtta ggaaactggc 1560 cgcacagcag gaggtgaaat gattattgca gtttcgaggg gagatgatgt cacaagatct 1620 cgaacccata tctcagaacc gcctgcctcc tcccacacac tctggctgtc ctgaccatca 1680 cttcaagccc accagccctg cagcaaaaaa aatcaaacga gtagttcaga aggcaaagtc 1740 tgcaagggaa ggaagtatat tgggaggtac agtaagtatt cctgtctgga gaaggtcttc 1800 tttggggcta gaaactgagc cagtgctaaa gccatgcagg aaggaggaaa taatcagtga 1860 gccacgggct gaacttgtgg aaaagaaatg gagggcaagg tcacaaacca gtccctaact 1920 gcttctaatt taatgtaatc ctcactgttt gtcattattg cttttgatgg ccatgaaatc 1980 tgttttttcc cagttctcta gtgtaatttg gaattaattt cccagctgct ttattttttt 2040 tctagaagag tcggggacat tttcaggatt agtagaggtg tttctacaac accttcatgc 2100 cttcgatagt gtgtaagagt tcaccaattg aattacctta ttctgttcag aagtagtaac 2160 tatggagttt aaccactctg gacatattat atacttaatg gagaccatag ctgtgtggtg 2220 actgagaaca tgcattgtct actccttatg gtgagactgc tttccttcat gaagtcagta 2280 aagaagggta acttttctgt agatttttgt atttttaaaa aaggtcaaga tcttcggcag 2340 ttttctgaat tgaattgttt gtgatatttg ctctgttttt aaaatcttct aaggccatta 2400 ccaggttcag tgcttatctt agtacaattt aaattgattc cgtgaataat ttttcctgcc 2460 tccagtttcc cttttacata gtgggctcat gttttaatat gttaaacaat tctgacattg 2520 aaataatttt attttatatt tttg catcca caaatactaa ttttctccat atattaatgg 2580 tgatgtagtt tctcctctgc aatattttat tgcctactca tgttttatgt cccctggatt 2640 acagcactgt cattccactg tgccctattt cttggttatg atgaaaagac tcttaattcc 2700 agtatgaaat catttctgca ttccataaat ttcatttggc atctgtggaa ttaaggcatc 2760 ttcattgtat ttggatctct gaatcataag tgatatttgc ctataaatta agcaatgata 2820 tttaaataag agattaccac aatcatattt tataaatata caaccatttt taaaaacctg 2880 acaaaatcta caaaaaaaag aaaatgaaat atatgtggag ttttagaaaa gactgactag 2940 gtccaaggtt gaggcacata gtggttaagc acattgtcag ctccggactc tgcctcttac 3000 aaggaaggag ggggctttag atgttattta gctgttattt agcctttcta cacctaagtt 3060 cccctcacct gtaaaaaaaa aaataataat aaattgctta ctttgtagaa tcattgtaaa 3120 tgttctatgt aaaatatgaa tatagtactc acagtaaata tgtgtgtgtg tggtgtgtgg 3180 tgtgtggtgt gtggtgtgta gttcagcaat agaaaatgga atttaataag aacgttatga 3240 gttgaaaaca atggtctgtg gacaatattg aatttcagtt gccaaaataa aatagacctc 3300 atgtttccct tcaggatcct ctaactctga aaatgaatag aagtatcagt cactggaaaa 3360 gaacaaatgt cctctaggga tgtggcaata ggaataatct tatctcagac cataattggg 3420 ttcctgatga aaatattttt tctttagcat tgtatttctc tttatttcac caaatgcaca 3480 ttaaggtcta cagatctgat tctcaaacac ctggctgtag ccacctcctt tgtgatactt 3540 tataaaggag ccccacagag aatgcctgct tttgggttga aacattttct caatcataat 3600 taggtacaaa cttgttttct atgttcacaa agtgggcagg gctgtgtgca ttggcaccac 3660 ttgccttttg aatatcttct aggccatcac agtcagcccc atgtactcct gctgggcaga 3720 cctgaaacta caagctccca aatagaatgg gtgctccaac atcctctgct ggattgtgat 3780 atgctggtaa ccgcacgtga ctggcaagtg gaatggcgaa aacaacacaa agaaggattt 3840 ggttactgtt ctgcagtagt taataactga tatggtttgg ctatgtcccc actcaaacct 3900 catcttgaat tcctatgtgt tgtgggagga acttggtggg aggtgattga attatggggg 3960 caggtctttt ctgtattgtt ctcgggatgg tgaatgagtc tcatgagacc tgatggtttt 4020 aaaaacagga gtttccctgt acaagctctc tctttgcctg ctcccatcca tgtaagacct 4080 gacttgctcc tgcttacctt ccgccatgat tgtgaggcct ccccaaccat gtggaactga 4140 aagtttgtta aacctttttt tcttcccagt cttgggtatg tctttatcag caatgtgaaa 4200 aaaaatggac taatacagca aagtggtatc agtag agtgg ggtgctgctg aaaagatacc 4260 caaaaatttg gaagcgactt tggaactggg taacagggaa aggttggaat acttga gat 4319 Asp 1 ggc tca aaa gaa gaa agg aaa atg tgg gaa agt ttg gaa ctt cct aga Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glug gac ttg ttg aat ggt ttt acc caa aat gct gat agc aat aaa gtc cag 4415 Asp Leu Leu Asn Gly Phe Thr Gln Asn Ala Asp Ser Asn Lys Val Gln 20 25 30 gct aag gtg gtc tca gat gga gat gag gaa ctt gtt gtt tgg agc 4463 Ala Lys Val Val Ser Asp Gly Asp Glu Glu Leu Val Gly Asn Trp Ser 35 40 45 aaa ggt gac tct cgt tat gtt tta gca aag aga ctg atg gta ttt tgc 4511 Lys Gly Asp Ser Arg Tyr Val Leu Ala Lys Arg Leu Met Val Phe Cys 50 55 60 65 ccc tgc cct aga gat ttg tgg aac ttt gaa ctt gag aga gat gat tta 4559 Pro Cys Pro Arg Asp Leu Trp Asn Phe Glu Leu Glu Arg Asp Asp Leu 70 75 80 ggg tat ctg gca gaa gaa att tct aag cag caa agc att caa gag gtg 4607 Gly Tyr Leu Ala Glu Glu Ile Ser Lys Gln Gln Ser Ile Gln Glu Val 85 90 95 act tgg gtg ctg tta aag gca ttc att ttt taaatcaata cctcctgaag 4657 Thr Trp Val Leu Leu Lys Ala Phe Ile Phe 100 105 tcctcctgag agcgccagat atgcattcgg gccacatgga gcagaaaagg agggctccat 4717 cactccctgc tggccatcag ggtgcagtgc aggacactca gagctcaata cttagttgtt 4777 tcccagtgcc ccctgctaga cctcctaccg aatcctgaaa ttctcaattt cttgatctgt 4837 ctgctccttt ggctgaacat gcgtcaaatc cacgggagca tcacaaaagg attctttctc 4897 agtcatgcct gtgtgatagg accttcttcc agtttctttc aaaaattgaa aaaaacatct 4957 gaatgatgca gtctacactt ctatcctcag actctgctgc agagcttcat cctgcaggac 5017 acagatgact acagggctgt ttgagatgga atcttccttt ctaaatcttc taggtttgat 5077 cacagtcaca aatgagcaga gcagatgaaa gtgaaaaatc ttctggcttg tccctatttg 5137 gggagagctc tccagaagta ttttcaagaa attagtagct attcgaggga gtgaaataca 5197 gctggtttgc cttcgagaaa ggaaagtgaa gtgtgctttt gtttcctctc atttaacagt 5257 tgcaaaaggc aaattataaa ataggaatac tcatgacact ttcttataaa tactgctaaa 5317 caaaataatc tacattcata tttttgtact ggtaaaatat ctgaaagcaa aatcatggga 5377 agatatttaa gtatattata catcatgaat ttcaaaaaca gagtgaagat catgatacag 54 37 gtttcttata tgaataactg tatggtttat attttccttc gccttttgaa atactcagga 5497 aatgtttgtt gtacacagaa tttgaataaa aattgtccag gccaggtgca gtggctcacg 5557 cctataatcc cagcactttg ggaggccaag gcaggcagat cacctgaggt cagaagttca 5617 agaccagcct gaccaatatg gtgaaacctt gcctctacta aaaatgcaaa cattagctgg 5677 gcgtgatggc aagtgcctgt agtcccagct acttgagagg ctgagatagg agaattgctt 5737 gaacccagga ggcggaggtt gcagtgagcc gagattgtgc cactgcactc cagcctgggc 5797 gacagagtga gactccatct caaaataaat aaataaataa ataaataaat aaatataaaa 5857 ataaaaattt ccatgcaaac ttttcttcaa tatatttttg ttacagttaa cgtaaaatta 5917 gctgttgtaa tagacaaacc tgaatttatc agcagtttga tcatcatgta atatttatca 5977 ttgctggcat ataccacctc aacacaggct ttcaaatgtc atgtgactct gcttgtggat 6037 tttcctccaa atatggattt agggaccccc ataccttcta ttggtgtatt tctcattgct 6097 aacctgtgtc ttcaaatctg gctatggtgc ttgggaaaat ttcatgcagt tgtatggcaa 6157 aaaatatttg gggcttcaca gagggtgttt tcacaggtca ggcctgtacc aggtaaatgt 6217 cgtttccacc cactcagcta ggatgcttgt atggccagac ctcagaacaa aaagcctggg 6277 gaa gggagtc ttgaactgtg agaccagcgg gaatacaaga ttggtctggt gaataagacc 6337 actgtttttc ttacactatg tgaaaaaaat gctgttaata tgagcaacag ccggttttcc 6397 tgctttcata catttacgca agaaaatgtg acttaaaatc taattccaca gattaaacct 6457 agagaatata tttcagggaa gagggcaaaa aggtcaatca ataaggctca cactgttgac 6517 catctgaaag gggattccca ttgaatccca aaagcacaga gtagagttga aatattccct 6577 agacaagtgt tgtcaaaaaa aatatgaaag tacattacat atgtaggaat atttagatat 6637 gaactgacac tagtgccaac actcagtcac cacgagaggc cctcaagcat ccaggatagc 6697 ctgttcttcc ctcagcataa ccataatgta acaagctaac cttttcacaa agggtggcta 6757 tgattataaa ccgagtatca gtaatgagtt aacacaggca acgataatat cttgctactg 6817 taacttaaaa acgtgttttt atgtccatca aaatcaagta gtgattgtgc ataaaatttt 6877 gtaatattta agggttaggt atccatcaaa catgttacag accaggcagt tactccagaa 6937 atacctttaa aaggagagaa ttattgcaaa ccacataaga tatttagtct gcattaggaa 6997 atgaaaatgc aagaaacatt ctgcaatgtg gaatgaacaa atatgattcc ttaaaatgca 7057 taaaactcag caaggacaga aaaccacgct gtttctccac tgtgctgtaa acacagtggt 7117 caacaaaac c acattaacat tttgccatgc ctttgtcaat aacttttctt ggcagcctca 7177 gatatagcct tcacttgcaa gacaagttga aagggtcttg taacatcttt ctcttttgaa 7237 aaccaattta tcaaaatgaa aaccttttat tgttgatttc accataaagt tagtagaatc 7297 tcagaaaaga tacagataat gcatatgtgt ctgagaaaga gctcctgtaa agcccaacac 7357 caaatacagg tcatatcata gaagtattgg tgtcctgcat tttgctcttg taattatacc 7417 tgcgtttatt actctgggga gattctcagg accagcattg ctgcattttg cttttctata 7477 ttttaattgt taatagatat tgtttggttg ccaaccccta aatgtggaac actttataat 7537 cgtaatatgc aaggtatgag aacacagtac ttctttcatc atctgtgatg tatgattatt 7597 caccctaatt ttcttgagtc tgagcagttt aacggaggta tatttttatt agttcactat 7657 tgtttaaatt tcttgtcttt tcatgctaaa aggaaagttg atatttatct atatctatgt 7717 ctgtatatgc atgtatatct atagaagtag atccatttgt ttgaacaacc ctctgtaatt 7777 aattgtgatg aattatgcct gttttagaaa gtattttgta cacatatttt taataaaaat 7837 tttccccccg aatatttaac cagt 7861 <210> 3 <211> 8407 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1821) <400> 3 cca gat gcg aaa gcc atg gag ttg agc tgc agc gaa gca cct ctt tac 48 Pro Asp Ala Lys Ala Met Glu Leu Ser Cys Ser Glu Ala Pro Leu Tyr 1 5 10 15 ggg cag atg atg atc tat gcg aag ttt gac aaa aat gtg tat ctt cct 96 Gly Gln Met Met Ile Tyr Ala Lys Phe Asp Lys Asn Val Tyr Leu Pro 20 25 30 gaa gat gct gag ttt tac ttt act tat gac gga tct cat cag cga cat 144 Glu Asp Ala Glu Phe Tyr Phe Thr Tyr Asp Gly Ser His Gln Arg His 35 40 45 gtc atg att gca gag cgc atc gag gat aac gtt ctc cag tcc agc gtc 192 Val Met Ile Ala Glu Arg Ile Glu Asp Asn Val Leu Gln Ser Ser Val 50 55 60 cca ggc cat ggg ctt cag gag acg gtg acg gta tct gtg tgc ctc tgc 240 Pro Gly His Gly Leu Gln Glu Thr Val Thr Val Ser Val Cys Leu Cys 65 70 75 80 tcg gaa ggt tac tct ccg gtg acc atg ggc tct ggc tca gt acc tac 288 Ser Glu Gly Tyr Ser Pro Val Thr Met Gly Ser Gly Ser Val Thr Tyr 85 90 95 gtg gac aac atg gct tgc agg ctg gct cgt ctg ctg gtg acg cag gcc 336 Val Asp Asn Met Ala Cys Arg Leu Ala Arg Leu Leu Val Thr Gln Ala 100 105 110 aat cgc ctc aca gcc tgc agc cac cag acc ctg ctg acc cca ttt gcc 384 Asn Arg Leu Thr Ala Cys Ser His Gln Thr Leu Leu Thr Pro Phe Ala 115 120 125 ttg acg gca gga gca ctg cct gcc ttg gat gag gag ctc ctg gct 432 Leu Thr Ala Gly Ala Leu Pro Ala Leu Asp Glu Glu Leu Val Leu Ala 130 135 140 ctg acc cat ctg gaa ttg cct cta gag tgg act gtg ttg gga agt tct 480 Leu Thr His Leu Glu Leu Pro Leu Glu Trp Thr Val Leu Gly Ser Ser 145 150 155 160 tca ctt gaa gta tct tct cac aga gaa tct ctt cta cac ctg gct atg 528 Ser Leu Glu Val Ser Ser His Arg Glu Ser Leu Leu His Leu Ala Met 165 170 175 aga tgg ggc ctg gct aaa ctt tcc cag ttc ttc ttg tgt ctc ccg ggg 576 Arg Trp Gly Leu Ala Lys Leu Ser Gln Phe Phe Leu Cys Leu Pro Gly 180 185 190 gga gtc cag gcc ttg gct tta ccc aac gaa gag ggt gcc aca cca ttag Gln Ala Leu Ala Leu Pro Asn Glu Glu Gly Ala Thr Pro Leu 195 200 205 gac tta gct tta cgt gaa gga cac tcc aag ctg gtg gaa gac gtc aca 672 Asp Leu Ala Leu Arg Glu Gly His Ser Lys Leu Val Glu Asp Val Thr210 215 220 aat ttt cag ggc aga tgg tcc cca agc ttc tcc cga gtg cag ctc agt 720 Asn Phe Gln Gly Arg Trp Ser Pro Ser Phe Ser Arg Val Gln Leu Ser 225 230 235 240 gaa gaa gcc tcc ttg cat tac att cac tca tcg gaa acg ctg acc ctg 768 Glu Glu Ala Ser Leu His Tyr Ile His Ser Ser Glu Thr Leu Thr Leu 245 250 255 acc ctg aac cac aca gcc gag cat ttg ttg gag gca gat att aaa ctc 816 Thr Leu Asn His Thr Ala Glu His Leu Leu Glu Ala Asp Ile Lys Leu 260 265 270 ttc cgg aaa tac ttt tgg gat aga gcc ttt ctt gtc aag gcc ttt gag 864 Phe Arg Lys Tyr Phe Trp Asp Arg Ala Phe Leu Val Lys Ala Phe Glu 275 280 cca gcc agg cca gag gaa aga aca gct atg ccc tcc agc ggt gca 912 Pro Glu Ala Arg Pro Glu Glu Arg Thr Ala Met Pro Ser Ser Gly Ala 290 295 300 gaa act gaa gaa gag att aag aat tca gtg tcc agc aga tca gca gca 960 Glu Thr Glu Glu Glu Ile Lys Asn Ser Val Ser Ser Arg Ser Ala Ala 305 310 315 320 gaa aag gaa gat ata aag cgt gtc aaa agc ctg gtg gtt caa cac aat 1008 Glu Lys Glu Asp Ile Lys Arg Val Lys Ser Leu Val Val Gln His Asn 325 330 335 gaa cat gaa gac cag cac agc cta gat ttg gat cgc tcc ttc gat atc 1056 Glu His Glu Asp Gln His Ser Leu Asp Leu Asp Arg Ser Phe Asp Ile 340 345 350 cta aaa aaa tcc aag ccg ccc tcg aca ttg ctt gct gca ggc cgg ctt 1104 Leu Lys Lys Ser Lys Pro Pro Ser Thr Leu Leu Ala Ala Gly Arg Leu 355 360 365 tca gac atg ctg aat gga ggt gat gaa gtc tac gct aac tgt atg gtg Le2u Ser Asp Met Asn Gly Gly Asp Glu Val Tyr Ala Asn Cys Met Val 370 375 380 att gat cag gtt ggt gat ttg gat atc agc tat att aat ata gag gga 1200 Ile Asp Gln Val Gly Asp Leu Asp Ile Ser Tyr Ile Asn Ile Glu Gly 385 390 395 400 atc act gcc act acc agc cct gaa tcc aga ggt tgc act ctg tgg cct 1248 Ile Thr Ala Thr Thr Ser Pro Glu Ser Arg Gly Cys Thr Leu Trp Pro 405 410 415 cag agc agc aaa cac acc ctt cct aca gaa acc agt ccc agt gtg tac 1296 Gln Ser Ser Lys His Thr Leu Pro Thr Glu Thr Ser Pro Ser Val Tyr 420 425 430 cca ctt agt gaa aat gtc gaa ggg aca gca cac act gaa gcc cag cag 1344 Pro Leu Ser Glu Asn Val Glu Gly Thr Ala His Thr Glu Ala Gln Gln 435 440 445 tcc ttc atg tca cca tca agt tcg tgt gct tcc aac ttg aat ctt tct 1392 Ser Phe Met Ser Pro Ser Ser Ser Cys Ala Ser Asn Leu Asn Leu Ser 450 455 460 ttt ggt tgg cat gga ttt gaa aag gaa caa agt cat cta aag aaa aga 1440 Phe Gly Trp His Gly Phe Glu Lys Glu Gln Ser His Leu Lys Lys Arg 465 470 475 475 480 agt tct agc ctt gat gcc ttg gac gcc gac agt gaga ggg cat 1488 Ser Ser Ser Leu Asp Ala Leu Asp Ala Asp Ser Glu Gly Glu Gly His 485 490 495 tct gag cca tcc cac atc tgt tac act cca ggg tct cag agc tcc tca 1536 Ser Glu Pro Ser His Ile Cys Tyr Thr Pro Gly Ser Gln Ser Ser Ser 500 505 510 aga act ggg att cct agt ggg gat gaa ttg gac tct ttt gag act aac 1584 Arg Thr Gly Ile Pro Ser Gly Asp Glu Leu Asp Ser Phe Glu Thr Asn 515 520 525 act gaa ccg gat ttt aat atc tcc agg gct gaa tcc ctt cct cta tca 1632 Thr Glu Pro Asp Phe Asn Ile Ser Arg Ala Glu Ser Leu Pro Leu Ser 530 535 540 agt aat cta cag tcg aag gaa tca ctg ctt tct gga gtt cgc tca cgt 1680 Ser Asn L eu Gln Ser Lys Glu Ser Leu Leu Ser Gly Val Arg Ser Arg 545 550 555 560 tct tat tct tgc tca tca ccc aaa att tct tta gga aaa act cgt ttg 1728 Ser Tyr Ser Cys Ser Ser Pro Lys Ile Ser Leu Gly Lys Thr Arg Leu 565 570 575 gtg cgt gaa tta aca gta tgc agt tca agt gaa ggt aag cat cat tta 1776 Val Arg Glu Leu Thr Val Cys Ser Ser Ser Glu Gly Lys His His Leu 580 585 590 aca ttt ggc ttt gaa aac act cta ttc cag aac aga ttt ttc agt 1821 Thr Phe Gly Phe Glu Asn Thr Leu Phe Gln Asn Arg Phe Phe Ser 595 600 605 tagtataagt acataaaata ttcaagaaca gcagacaaga attttccatt ctgttttcat 1881 aactggtttt tctaagcctg acaaaattct tttcttattg gataacagcc aaatttgatt 1941 ttgatcagat ttgattttga tgaaattaca aatacatgca cacctctctg ttactttatt 2001 ctttgaataa aatgttttcc tcaaggatag tgtaaattag aattgattcc agttatatta 2061 ttatgagggc cttagaggat tttatttgag taaattataa aaattacttt tgtctcatat 2121 atacattgct aacataatcc aactcctcag agccagagtg ttgcagaatg gattttcttcc 2181 tttcttttttt tagaaaggga attttatag attga tattga cat attga ctcaa catttttttg gtggcaatgt aggcaattag aaatataact tttaggcaat 2301 aaacttaatt taaatgtagg atacatacaa aaaggagtgc aaatcataaa tatgcatctt 2361 gaattttcaa gtgaattcag atctataaat ggaaaaatta tgtacaactt agagctcccc 2421 ttgtatcctc tctaagccac tcctcccatt ttcacctgcc cccattttga aatgtaatta 2481 tttcatactt tctgtaatta atatgtaata attgtattaa aaagcatatt tgaaagtatt 2541 catgccaatg cataatacat agcattataa tgaaattttt gtcaatgtct tagagaatat 2601 ctttattgtc tattatcctt aagggactta aaagattcag aaagcaagag atgaacttaa 2661 gtactctgaa gtactactca aatattttct taagataaaa tatttaaaat aggatttatt 2721 ttattccctc tcttttttct tattcttgct tattaaattg ttattttgca tttttatgcc 2781 atgcagaaca atactgaaaa cataatcttg gtgcttgaaa cagctatcct agaataatga 2841 catatatgct agatgttcaa taaatatttg ttgaatgagt atgagaaaaa gatagataaa 2901 acacaaaaga aatgctacca tgatttttgt tttccttttt ctgggatgta ctgttagaag 2961 agaagagagc aagactgata atacatgtca gtttttattt ttggatgggg agatgaagaa 3021 aagttacaag agaaagaaag gatacaacta ccttgagagg gcaggataaa taagatggat 3081 tgaatttgtt ctggattttt gttttttact tcatgggttc tttctaggtc tccaggtctc 3141 cccagcctta gtttaggttg gtgtattttt aatagctcga cacctcttca ctgatagtcc 3201 cagctgatga attaacctca cattgttact atttggaaaa catgtttaag ttttctgtgc 3261 ttcaaattat ggctttgcct ttagatctgt ggtccttgat ctatgaagtc agatatctct 3321 agagtttgaa attattgacc acacaattaa gaggaaactt attgttcaca agggaaaata 3381 gccctaattt acttattctt taatgatcaa ggaagggtgt ctttacctta catgcaagcc 3441 tgaaaccttt gcatatgagt tagaataaaa agctgatctc aactgctttg gttttcagta 3501 aacgaaacct tatctttaga cggtatattt aaagacaagg ctacttgagt gaagtttgat 3561 actatccaga aggtaacagt tagaaccagg caatttaggt tgagtctact cactaaatat 3621 atgaaaattc cagtggatag acttatatgg ctgcaaacat ttggattgat accatttagg 3681 tcagtcaata ccataggact atgaaaaata aattaaccac taatgaagaa ggaataattt 3741 tatctgtgtt tatgtaatca aagcacaaat gtgaaagctt gcctaatgca aagatatatt 3801 ctaatgtttc attgtttagt cggcttggat taatcaaaag taaattgagg tttgtgttgc 3861 cataaatcct ttcttgatga gttttgaata gtcctaaaaa ttttcaggtc tatttgaaca 3921 gagtccaagt ctcct tatgt cccagaggga agctcccata tgagagctgt aatgcagata 3981 tacaaaccta ggatgctttc ggtccttttt attattattt gtgatgttct gtcttccttg 4041 tcacttccaa agagttactt actgtaattt ctcatgcgtc tttttttttt ttttgagcca 4101 agagtacgat gatggcaact ttatttttga tgtttgtata cataaaacaa aatccagttt 4161 tataattccc tttggtctat tatagattta ggcagaaagg aacattgcca atattaaaat 4221 gataactaca gtctcaccaa gggggacaaa ggggttcagc atttaagaat ttgaggaatg 4281 acgtaaacat acttttgaaa acgttgtgag ctgatggatg gaatttaatt ggattttgaa 4341 cagttggtgg cttattctct tggtacttca gcctatttac cataagaata gtgagttctg 4401 cctatgactt aatttgagga acacttgata atggctataa aataaaggct tcaaattctt 4461 caaagtagat ttcctattac atacaagata gtattaggtg caacatttga tattacccat 4521 ttcaggggat atgtatttgt tttcctcctt atgtatcatt tccctttgca acctagttat 4581 gcctcttcac tgttctggat tgtgagagtg aaggatttgt ccctgccctg tagatggtgt 4641 gctccacagt gactgccccc tccttcaggc tctctcactg tctaaatcag tgtctctact 4701 ccacccctgt agtaagtatt tcaactctgg aaacaagatg gctccaagct gcttgcatga 4761 acctcccttc tggccccctc cacaagtcca atgaaaaaaa tggtcctccc tttcccatga 4821 gccacagagc acatctctga acttgctgct gctaggattt tatgaggaca ttgcagctat 4881 atgaaaatta actcttctta tgctgtcctt caagacttca tttgagcttt gtttaaaagc 4941 agttatttat tggttctgta tgttagggca ttagtgttat gaagaatagg gatgactcta 5001 gtgaaaagta tccaaaaaga tagagctaat tttctgcact tctgaaaatg tttgctgtcc 5061 cttgctgatg ctaacttagt tcatgaagtc attaaatgtt ggcatatttt ggccatgttt 5121 ctccctaccc tctttaaatt acagaaagtg atttaaaaaa atccagagca atgccttact 5181 tatataaggt aactcatttt ctcattattt tctagctggt agtgtgtata atgatacaat 5241 atggttgagt atgcatttca gactaacata tgactgccag tttgtgtgcc ttagttttca 5301 ttttattgtt ctgtgtcttg tagagcaaag agcttacagc ttatcggagc caccaagaga 5361 aaacaggtac ttttaactat tccaattttc ctgaggaact gcatgatcct tctttggaaa 5421 tgtccacaca tcatttttgc tatctgttca ctagttcatg agaggtttcc atgtaacaag 5481 cctgcctaag accctttgct ccctctggga tctgtatcag gatagatctg ccagccctcc 5541 cctttcagtc cttggctgtg caggcctcag gattggggac agcatgttct gtctgggtat 5601 cttcaaagcc aaataccctc aagggg agca gtgtgagggg accacctgtt ttagaaagac 5661 aacatgtttt ctccagctct attccaccat gacaagggga cttactttag taacagaacc 5721 ctgggtggtc aatgatagaa agtgcctaaa catccctact gtctctctat ggatttttgc 5781 ctagtagccc ttcagctgga aacaaagaat aaacaatgca gaagactttt aagcatgatc 5841 agtttcctgg ttgagatgca gatttaacct aagcttctct ttctcctaga aggtaaaact 5901 gttgttggag tatagcttgg gaagcagacc agtgtgcaag catgattgtt ggtttctgtt 5961 ggtgttgaat aactaactgc ccatgagtca cactgtgaaa tagccccagg gttgtatgca 6021 aaacaagtgc cagaatggca cacatgtttg actttaagag accatctgaa aagagtgaaa 6081 tggtttaatt ttgtttgaga ttaatactaa aactttgaaa cgttttaaac gttttagtat 6141 acggatcaag atggggtgtt tcgttttaaa tcctggaatc aaagtattaa taagaaaaag 6201 cctcctttgg atcatttcta tttttttttt gaaaccagaa tagaaacttt caaatgatac 6261 aaaagaggaa gattaagaat gcccttgaaa gataggatga tgatcaagtt gacttcgtga 6321 caatggcaat gaggatgatg atagcaaaag cagtaattac tgacaaatat tgaacatttg 6381 tatgtgcctt gtactgtttt aagcagttta catttattat ctcatttaag caatttactt 6441 cctcattctg gaatttgatc ttcatcttgg tcatcatttt gattaacagt catcttttta 6501 acaactggaa aaataatgga ttgttatcaa gaatttttta aattaaaaat ataaaaaata 6561 ttcatttgtc attaggagag agatttaaga ccgaaggagc caatgttata cttggctaaa 6621 tagtagccta taaaatattt tcactttgat ggcatcttta tgaagtttct ttttatctgg 6681 ttcttcgttc tctgtcactc ttgtttttgt tttctgttcc tttctattct ttaatctttc 6741 ttggtccaca tcctgaaagc atcttactct ctcagtcata tgccttggtg tatctagtag 6801 agtggatctt tcatctcacc cactctattc ctgctatctt atcttgttgg atatgccaat 6861 aagatcccaa gccataccta atgctttgct ttggtcatgt tacaggtatt tacctgagat 6921 gatgccttct ttgatattct cttatttgta ttaatcactt agtttctaga aaaggggaca 6981 tccatgtaaa aaatgagctc actctatacc ttgcaggctc atttcagcag acactctgtt 7041 ctaatttctt aaagattata tggcatgact tgattatttt actgccacca tctgtcttaa 7101 atctattgta tgtatttcct ccttctcctc ctctttcttc aaatctgagg atctgagtgt 7161 taacagaagt tccactgtgt caattttcaa tctgcatagc aggaacttct ttcagccctt 7221 taggcccggt gcggtggctc atgcctgtaa tcccagcatt ttgggaggca gaggcgggcg 7281 gatcatctga ggtcaggagt ttgagaccag cctagt caac atgaggaaac cctgtttcta 7341 ctaaaatata caaaaattag ccaggtgtgg tggcaggcgc ctgcaatcac agctactcag 7401 gaggctgagg cagaagaatg gcttgaacct ggaacgcgga ggttgcaatg agccgagatc 7461 gtgccacagc atcctagtct gggcgacaga gccagactcc atctcaaaaa aaaacaaaaa 7521 cccaaaaaca acaacaacaa caaaaaaaca ctttagatgc caattcttta aatagattaa 7581 gggttaaaat attaagaatc catattctta atatgtttta aatgtctatt tacctattga 7641 aaaggcagta ccattaaagg ctctgagaag ggtttgtaaa actttattgt gagtgatgct 7701 atcggtcatc aaactaataa tagagattag acgttcttgt tctgggatgt taaaaataac 7761 ttaatctttc cagattctta caaatgtaaa agctatttaa attctattat gaaattattt 7821 gaaggttttc tcttctcaat tattttctaa agtgcctgat tttgatatag gtaaatatca 7881 cataattaaa ttagatatga aatgaagcaa ccaaccttct acatttgccc agaggttata 7941 cagtattacc catcttcata atctgatagt ggattatgac tatgatattc acatttctac 8001 caggttgggt gatggtttaa gttttcatat ttcataatta ataatatttt taaaaaagca 8061 tttttatgtt tacactgtta tatctcaggt cttatcaacc tcagcttaaa aagttgaagt 8121 atcggctggg cgtggtggct cacgttttta atcccagcac t ttgggaggc cgaggtgggt 8181 gaatcaccag aggtcaggag ttccagacca gcctggccaa catggcaaaa ccccatctct 8241 actaaaaata tgaaaatcag ctgggcctgg tggtgggcgc ctgtaattcc agctactcag 8301 gaggctgagg caggtgaatc acttgaacct gggagcctga ggttgcagtg agccaagatc 8361 acgccattgc actccagcct aggcaacgag agcaaaactc catctc 8407 <210> 4 <211> 7999 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (958) .. (3594) <400> 4 cagtgatgag ttctagaagg aaagaaaagg ctgatgtgac agtgaggaag ggatgagtgg 60 agacttctct gagacttcag tgattcctct tcctctgagc tgagccaagc tgagaagctg 120 agaagagtaa gatagggccg ggaactcagg tccgttagtc cgtcctccga ggtggggcgg 180 gccagcagaa tggatttccg atctactctg tgagagcctc gcccaagaaa gcccagagcc 240 acttccaaga tccgcgctcc cacggcgatg agaagcgttt tcccccggga ctgcttggct 300 taggactggg gacccactgg ctttggagta agccctggca cgggcctcga gggaagaaag 360 aactcccgcg ctccccacac tccacagggc ctgcgatcat ctcagatgtt ccggttccac 420 gtgcagaaac cccgccggtc cgaggccccg gttctaaaac ggccctaaga gtcaaggctt 480 ccacagctcg cctctgaggg tggcaaagag gccgcggggg cggtgcctcg cgagacccaa 540 acaagcccac gtggcagggg cggggctccg cgaaggcgtc acggcgcgct cgtgcgctgc 600 tgaggtcacg cgccggcagt acccttgccc gggggccgta aagcgcggaa ggtcgcggtc 660 tcggcttccc cggaactttt tgctcgcttc gccccgcccc cttcccatcc ccgaaccccg 720 ctttccggcc cgcggcgacc ccaggcaact gttgtggctg ccgcattgct cccgccgggc 780 tgtagctgag cgcggagccc gtggggaccg gtgagatgga actgttttcc cgcgttgaga 840 cgtgcggtcc gc ttgtgctt ttagaactaa agactgctgc agagtccgga ggaagaagtc 900 acctagaaaa atctgggaca gggcatttga gttcctgaga tctagttggt gagagac 957 atg atg ttc tac cgg ttg ctg tcg att gtt gga aga gall Ager Gag Ager Gag Ager Gag Ager Gag Ager Gag Ager Gag Ager Gag Ager Gag Agall cca gga tgg cag aac tgg tcc tct gca aga aac agc acg tca gct gcc 1053 Pro Gly Trp Gln Asn Trp Ser Ser Ala Arg Asn Ser Thr Ser Ala Ala 20 25 30 gag gcg cgt tcc atg gcc ctg ccc acc cag gca cag gtg gtc atc tgt 1101 Glu Ala Arg Ser Met Ala Leu Pro Thr Gln Ala Gln Val Val Ile Cys 35 40 45 gga ggt gga atc acg ggc act tct gtg gcc tat cac ctc tcc aaa atg 1149 Gly Gly Gly Ile Thr Gly Thr Ser Val Ala Tyr His Leu Ser Lys Met 50 55 60 ggg tgg aag gat att gtc ctt ttg gag cag ggc agg ctg gct gct ggc 1197 Gly Trp Lys Asp Ile Val Leu Leu Glu Gln Gly Arg Leu Ala Ala Gly 65 70 75 80 tct acc agg ttc tgt gct ggc atc ctg agc act gcc agg cac ttg acc 1245 Ser Thr Arg Phe Cys Ala Gly Ile Leu Ser Thr Ala Arg His Leu Thr 85 90 95 att gag cag aag atg gca gac tac tca aac aaa ctc tac tat cag tta 1293 Ile Glu Gln Lys Met Ala Asp Tyr Ser Asn Lys Leu Tyr Tyr Gln Leu 100 105 110 gag caa gaa aca ggg atc caa aca ggt tac aca agg aca ggc tca atc 1341 Glu Glu Thr Gly Ile Gln Thr Gly Tyr Thr Arg Thr Gly Ser Ile 115 120 125 ttt ctg gcc caa act cag gac cga ctg atc tcc ctg aag cgc atc aac 1389 Phe Leu Ala Gln Thr Gln Asp Arg Leu Ile Ser Leu Lys Arg Ile Asn 130 135 140 gca ggg ctg aat gtt ata ggt atc cct tct gag atc atc tcc ccc aag 1437 Ala Gly Leu Asn Val Ile Gly Ile Pro Ser Glu Ile Ile Ser Pro Lys 145 150 155 160 aaa gtg gcc gag ctt cac cat ctc ctc aac gtg cac gac ctg gtg ggg 1485 Lys Val Ala Glu Leu His His Leu Leu Asn Val His Asp Leu Val Gly 165 170 175 gcc atg cat gtt ccc gag gat gca gtg gtg tct tcc gct gac gtg gct 1533 Ala Met His Val Pro Glu Asp Ala Val Val Ser Ser Ala Asp Val Ala 180 185 190 ctt gcc ctg gca agt gct gcc tcc caa aat ggt gtt cag atc tat gac 1581 Leu Ala Leu Ala Ser Ala Ala Ser Gln Asn Gly Val Gln Ile Tyr Asp 195 200 205 c gg aca tct gtt ctt cat gta atg gtc aaa aaa ggt caa gtt act gga 1629 Arg Thr Ser Val Leu His Val Met Val Lys Lys Gly Gln Val Thr Gly 210 215 220 gtg gag acc gat aaa gga cag att gaa tgc cag tat ttt gtc aac tgt 1677 Val Glu Thr Asp Lys Gly Gln Ile Glu Cys Gln Tyr Phe Val Asn Cys 225 230 235 240 gct ggc cag tgg gca tac gag ctg ggt ctg tcc aac gag gag ccg gtt 1725 Ala Gly Gln Trp Ala Tyr Glu Leu Gly Ser Asn Glu Glu Pro Val 245 250 255 agt atc ccg cta cat gcc tgc gaa cac ttc tac ctc ctg act cgc ccc 1773 Ser Ile Pro Leu His Ala Cys Glu His Phe Tyr Leu Leu Thr Arg Pro 260 265 270 ttg gag acc cct ctg cag agc agc aca cca act att gtg gat gct gat 1821 Leu Glu Thr Pro Leu Gln Ser Ser Thr Pro Thr Ile Val Asp Ala Asp 275 280 285 gga aga att tat att cgg aac tgg cag ggt ggc atc ctg tct ggg ggc 1869 Gly Arg Ile Tyr Ile Arg Asn Trp Gln Gly Gly Ile Leu Ser Gly Gly 290 295 300 ttt gag aag aac ccg aaa cca att ttc act gag ggc aag aac cag ctg 1917 Phe Glu Lys Asn Pro Lys Pro Ile Phe Thr Glu Gly Lys Asn Gl n Leu 305 310 315 320 gag att cag aat cta cag gaa gac tgg gat cac ttt gag cct ctg ttg 1965 Glu Ile Gln Asn Leu Gln Glu Asp Trp Asp His Phe Glu Pro Leu Leu 325 330 335 agt tcc ctt ctg agg agg atgca gaa tta gag act ctg gag atc atg 2013 Ser Ser Leu Leu Arg Arg Met Pro Glu Leu Glu Thr Leu Glu Ile Met 340 345 350 aag ttg gtg aac tgc cca gag acc ttc aca cca gac atg agg tgc atc 2061 Lys Leu Val Asn Cy Pro Glu Thr Phe Thr Pro Asp Met Arg Cys Ile 355 360 365 atg ggc gag tct cct gca gtg cag ggc tac ttt gtc ctg gca gga atg 2109 Met Gly Glu Ser Pro Ala Val Gln Gly Tyr Phe Val Leu Ala Gly Met 370 375 380 380 aac tct gct ggc ctt tca ttt ggt gga gga gcc gga aag tac ctt gcc 2157 Asn Ser Ala Gly Leu Ser Phe Gly Gly Gly Ala Gly Lys Tyr Leu Ala 385 390 395 395 400 gaa tgg atg gta cat ggt tat ccc tca gaa aac gtt gaa ttg gac 2205 Glu Trp Met Val His Gly Tyr Pro Ser Glu Asn Val Trp Glu Leu Asp 405 410 415 ctg aaa cgt ttt gga gcc ctc cag agc agc cgc acc ttt ctg cgc cac 2253 Leu Lys Arg Phe Gly Ala Leu Gln Ser Arg Thr Phe Leu Arg His 420 425 430 cgg gtc atg gaa gtc atg cct ttg atg tat gat ctg aag gtt ccc cgc 2301 Arg Val Met Glu Val Met Pro Leu Met Tyr Asp Leu Lys Val Pro Arg 435 440 445 tgg gac ttg ca acc ggt agg cag tta cgc acc tct cct ctc tac gac 2349 Trp Asp Phe Gln Thr Gly Arg Gln Leu Arg Thr Ser Pro Leu Tyr Asp 450 455 460 cgg ctg gat gca cag gga gcc agg tgg atg gag aaa cat gga ttt gag 2397 Arg Leu Asp Ala Gln Gly Ala Arg Trp Met Glu Lys His Gly Phe Glu 465 470 475 480 agg cca aag tac ttt gtt ccc ccc gac aag gac ctc ctg gca ttg gag 2445 Arg Pro Lys Tyr Phe Val Pro Pro Asp Lys Asp Leu Leu Ala Leu Glu 485 490 495 cag agc aag act ttc tat aag cca gat tgg ttt gac atc gtg gag tct 2493 Gln Ser Lys Thr Phe Tyr Lys Pro Asp Trp Phe Asp Ile Val Glu Ser 500 505 510 gaa gtc aag tgc tgt aag gag g tgt gtc att gac atg tcc tct 2541 Glu Val Lys Cys Cys Lys Glu Ala Val Cys Val Ile Asp Met Ser Ser 515 520 525 ttc aca aag ttt gag ata aca tcc act ggg gat cag gca tta gaa gtt 2589 Phe Thr Lys Phe Glu Ile Thr Ser Thr Gly Asp Gln Ala Leu Glu Val 530 535 540 cta cag tac ctc ttc tcc aat gac ctg gat gtg cct gtg ggc cac att 2637 Leu Gln Tyr Leu Phe Ser Asn Asp Leu Asp Val Pro Val Gly His Ile 545 550 555 560 gtg cat act ggc atg ctc aac gag ggt gga ggg tat gaa aat gac tgc 2685 Val His Thr Gly Met Leu Asn Glu Gly Gly Gly Tyr Glu Asn Asp Cys 565 570 575 agc ata gca cga ctg aac ag cgc atg atc tct cca acc 2733 Ser Ile Ala Arg Leu Asn Lys Arg Ser Phe Phe Met Ile Ser Pro Thr 580 585 590 gac cag cag gtc cac tgt tgg gcc tgg ctt aag aaa cac atg ccg aaa 2781 Asp Gln Gln Val His Cys Trp Ala Trp Leu Lys Lys His Met Pro Lys 595 600 605 gac agc aac ctg ctc ctg gag gac gtc acc tgg aag tac aca gcc ctc 2829 Asp Ser Asn Leu Leu Leu Glu Asp Val Thr Trp Lys Tyr Thr Ala Leu 610 615 615 620 aatc ctg att cct cga gct gtg gat gtg ctg tct gag ttg tcc tat 2877 Asn Leu Ile Gly Pro Arg Ala Val Asp Val Leu Ser Glu Leu Ser Tyr 625 630 635 635 640 gcc cct atg act cca gac cac ttc cca agc ctc ttt tgc aag tg 2925 Ala Pro Met Thr Pro Asp His Phe Pro Ser Leu Phe Cys Lys Glu Met 645 650 655 agt gtg ggc tat gca aat ggg atc cgg gtg atg agc atg acg cac aca 2973 Ser Val Gly Tyr Ala Asn Gly Ile Arg Val Met Ser Met Thr His Thr 660 665 670 gga gag cca gga ttc atg ctc tac atc ccc ata gag tac gcc ctg cat 3021 Gly Glu Pro Gly Phe Met Leu Tyr Ile Pro Ile Glu Tyr Ala Leu His 675 680 685 gta tac aat gaa gtg atg gtt ggc cag aaa tac gga atc cgg aat 3069 Val Tyr Asn Glu Val Met Ser Val Gly Gln Lys Tyr Gly Ile Arg Asn 690 695 700 gct ggg tat tac gct ctt cgc agt ctc cga att gag aag ttt ttt gcc 3117 Ala Gly Tyr Tyr Ala Leu Arg Ser Leu Arg Ile Glu Lys Phe Phe Ala 705 710 715 715 720 ttc tgg ggt cag gat ata aat aac ctc acc acg ccc ctg gaa tgt gga 3165 Phe Trp Gly Gln Asp Ile Asn Asn Leu Thr Thr Pro Leu Glu Cys Gly 725 730 735 cga gag tct cgg gtg aaa tta gag aag ggc atg gat ttc att ggt cgc 3213 Arg Glu Ser Arg Val Lys Leu Glu Lys Gly Met Asp Phe Ile Gly Arg 740 745 750 gac gcc ctc ctg cag cag aag gag at tg tat aaa cgc ctc acc 3261 Asp Ala Leu Leu Gln Gln Lys Gln Asn Gly Val Tyr Lys Arg Leu Thr 755 760 765 atg ttc atc ctg gac gac cat gat tca gac cta gac ctt tgg cct tgg 3309 Met Phe Ile Leu Asp Asp Asp Ser Asp Leu Asp Leu Trp Pro Trp 770 775 780 tgg gga gag ccc att tac cgg aat ggg cag tat gtt ggc aag acc acc 3357 Trp Gly Glu Pro Ile Tyr Arg Asn Gly Gln Tyr Val Gly Lys Thr Thr 785 790 795 800 agc agt gcc tac agc tac agc ctg gag cgc cac gtt tgc ctg ggc ttt 3405 Ser Ser Ala Tyr Ser Tyr Ser Leu Glu Arg His Val Cys Leu Gly Phe 805 810 815 gtg cac aat ttt tct gag gac acg ggg gaga gag cag gca 3453 Val His Asn Phe Ser Glu Asp Thr Gly Glu Glu Gln Val Val Thr Ala 820 825 830 gat ttc atc aac cgg gga gag tat gag att gac atc gcg gga tac cgc 3501 Asp Phe Ile Asn Arg Gly Glu Tyr Glu Ile Asp Ile Ala Gly Tyr Arg 835 840 845 ttc cag gcc aag gcc aag ctc tac cct gtc gcc tcc ctc ttc acc cag 3549 Phe Gln Ala Lys Ala Lys Leu Tyr Pro Val Ala Ser Leu Phe Thr Gln 850 855 860 aag cgc cga aag gat c atg gag ctg agt gac tta cat ggg aag 3594 Lys Arg Arg Lys Asp Asp Met Glu Leu Ser Asp Leu His Gly Lys 865 870 875 tgatgccacc agggcagcct cacctcctcc ccatcatctt gtcctagagt gggcgtcacc 3654 ttggagcttc tcttccttcc gcctctgttc ctcttctgga gcctttgcct cccatctctt 3714 atctccttga tataattttg aacttgacct actttaaact tttttgctct gcagccttcc 3774 ttgcccttcc acctcctcct cctaatattc actctgggct cttcttccct tcccacccct 3834 cactcagctt ctcgtggtgg caggaggtat gtctgacagg acagaagcaa gctccactgt 3894 ggacatgagt gatggtgaca gctgctttca aattctgcat ctcaaggcag ggcaagccgg 3954 ggtggtgcag gtctcagggc acgagtccct ctcccttggg ttccattttc ttggagcagc 4014 ctattagttc tggtggggtt gccgtgtgtc ggatgcagcc ctgaggggca gctcgtgcct 4074 gcagcccggc agctcgttct cctgttctgc tgtgctgtgg gctggcactc gatacctctg 4134 gcaagaggat gattatctac ctcactgata agaggcatcg catggacgtt ctctggtctg 4194 tagtggagac aagcagttaa cctagcacca tcctcatcct ccctgcagaa gccattagca 4254 gacctttggg ccagggcagc ctccctataa ttttcttcat ctcttgctaa tctctataat 4314 aaggttgctt tttctttctt agttgagtaa acaagtaagc cacagtgttt gaaagggaaa 4374 aaccatattg ccttgtgtgt tgcttttccc agtcaaaagg gtctgacctt agaaagtccc 4434 caccagtgat gctgagtgtt ctgctatgga aacaatgctg cttttctctc agctgtccaa 4494 agttcagccg ttcctccttc cccttctccc agtgcgtttg actttgtcag gtcagcctca 4554 cttgtccctt tcacagttgg cccataaagt catgtttctc tccctttaga atagggaggg 4614 gaagggatca ggtgtgttgt cctgggcctt tcaaccttgc gggctgtgct gagttccaga 4674 gagctgccgg aattccaggt ttgactctcc agcacagagc agagctacac agaggtgacc 4734 cacgttagtc cactgagagt tctgagtcca aagggtgtac gttgcataag gctagagacc 4794 gcttttcctc ctttcccccc aggctctttg tttccctcca cccacccttc catatcctct 4854 ggagcaggag acaatgtggg tgcccagaag tgccctgcgc tttcaggcag tgtctctgtt 4914 ttcccaaggt gaaacttaga tatcatggac tgttgtccag cctcaatgct tcattttccc 4974 cttgcatatc aactgcccta atctgacttt ttttaagtgc aaataaactg ctataagaca 5034 ttttggttag taaaactcta gcctttggcg tgttggtatc ttggaagcat tagctctgat 5094 aggtctataa gtgtattaag ggacatcctt ccatttcatt agagcagctt aaaatgctca 5154 ggtgtctgcc ttctctggtg tttctttggg atctc tgttt acccacttac gctggctcct 5214 tctagacatt tcttgccact tccccaacta gaccactcct agtgattact gactttagtg 5274 cctaaacctt tttggaaggt tctggttggc ttgttagagg agcatatgat tagaattctg 5334 tttgggggtc tagttgtctt ggagcaagta tgtacttaac tagccgagag atgctgcctc 5394 taggcagaga ggaggagagg tgttgccggc tggagggcca accagtgaac accagctgtg 5454 aaggccttgg gagaggagga acaggccctt gggcagatgc aggcattacc agcagggagc 5514 agacttacct ccgaagatgg agacaggtga ctgagagctg caggcctcct ctgctcttcc 5574 aaacacgtag catttgcacc cctccaaagc catctttgta aaggaaaacg tatttgtaat 5634 tgaatccaga agaatttagt tacacataga cataactctt caaccttaac tatggcaata 5694 catttgtgct ttaactgtta catagcagta tcaccactta ccaggatcca aatcgaaata 5754 ataaaagctg tctccatagt ttaaaatcga atagtgccat catcacagta tattagtcaa 5814 atagaagctt catcagaaat gtatcccaca tagagtttta agacttggat tctcttctgc 5874 ccttgttaat ctccaactaa ttactacaga ttgacacgtt tttaattagc tgtcctttgt 5934 aagaagtcag gaaatctgat gctgtgtcca aaattatgca ctgtttgttg aagtagaacc 5994 agaaatcctg acctcctgtt aaatgacatc agtttccccc tctgagcaac agactgcttg 6054 tcttgctagg agaggaggat ggggggctga gcactcaggc tgtccattga aaccccttgt 6114 ccatgaatag ggtcatactc ctaagactga tggggtgttg atcttctagg acatcacttg 6174 tttattcagt gccccaaaca cagatttctc ttctagcact ttagagttga tccttgaagt 6234 ctctcctggt tcattcaaat acaagctgtg tgagtctggt ggttttctgt gattggtcta 6294 atgtgagctc tttgaacaga cagatctgac agtgaatgac tctcccctgc ttctggcata 6354 actgctttgc ctctgtctag tgtccaagca tcttagctgt tcaagaggag agggcagcat 6414 aacttcctga ccaccggtgt cagatatcag agcattctgg actcctgaga ggcagtggcc 6474 tcttgagtga acaggggagg ccagtagatg ccccagatcc agagccgtgg ctgcaaatcc 6534 agcaggaata aggagggaca accacagcct cctcatccat gtgtcatttc caagggtttg 6594 ccttgtgtct cagctcattc tgggcagcac gtttgtcttc tgtccctaga gatttgaagg 6654 attttggact cttgtgaatg ggtgactgga cttggcttta cagagttggg tgcttttttc 6714 tctctgcaat tacctgtcat agcattttgt gctcaccacg aaggatggtc tctgccttct 6774 cttgtcggtg tatgccatct gaacctagga acacaaagta tattggcctc aaacggagac 6834 ccagggttgc cagttttccg tgggccttcc cctcccttga aatgtc ttta attacctccc 6894 cttcatcgtc aggccacgtg tgacttctgt tcttagcact gccagggtca ttgacttcca 6954 tctaagcttg catcaggaag atgttccttc tgtgatcatt ggtactgaag ccagaaaagc 7014 tctcattcag gaactctgaa gagcaaaaag ggacaaacac taactgctga gctgggccat 7074 ttgatctcct ttcaccttgc attgctgtca cagcaccttg tatgatggca ggacaggctc 7134 cagcagagag aactgcacag tgaccactgt atttttcacg ctcttccagg gatccctgtc 7194 ccccgacatt gaagagatct cattcaggcc agagacacag agaccacata gcccagtgat 7254 taaaccccgg tttcactctg gccccaggag tggagcctgg ccactcctgt ttggttctca 7314 ctgggaggcc cactggcctt ggatcatctc ctcatgcaca cccggagttt tacctgcttg 7374 cttgctttcc tggactgctg tttgcaagaa agtaactaaa acatgaaaag taaacctcca 7434 gcttccacag tatattacct gccgttgcat gcatttgaaa gttagcctcc tcccttgcca 7494 ccgtcttggt ggcagtagcg atgcaagaat gatgggagct ttccgagagc gttcagtgtt 7554 tcactgaaga caggacccat agccttcatt tctggctctg tgtctcctct ggcatatgga 7614 cacatttcct ggcatttgcc tgagtctaca ccactttttg agaacctgaa atagaaggga 7674 atcttctgtg gcccacagtc tccatattgg cactagaaga ctggcctggc ggaggaattt 7734 gcgttggctt gctttcaggg gttagctaca agattcagct ttatatctct gttgcttctt 7794 ggccagtgta gtcaataagg gtcttcttta acatctaaga tagaggtttg gttggccggg 7854 cgtggtcgct tactcctgta atcccagcac tttgggaggc ccagtgaggt gggagaattg 7914 cttgaaccca ggaggcagag gttgcagtga gctgagattg caccactgca ctccagcctg 7974 ggtaacagag tgagactctt gtctc 7999 <210> 5 <211> 8282 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2293) <400> 5 t gag aaa cca gcc att gtc ttc atg tac agg tgc gac cct gct caa ggc 49 Glu Lys Pro Ala Ile Val Phe Met Tyr Arg Cys Asp Pro Ala Gln Gly 1 5 10 15 cag ctc agt gtg gat cag agc aag gct agg aca gac cag gca gca gtc 97 Gln Leu Ser Val Asp Gln Ser Lys Ala Arg Thr Asp Gln Ala Ala Val 20 25 30 atg gag aag ggt aga gca gag aat gca tta cta cag gac tca gag aag 145 Met Glu Lys Gly Arg Ala Glu Asn Ala Leu Leu Gln Asp Ser Glu Lys 35 40 45 aag agg agt cat tct tct cca tca cag att cct aaa aag att ctc agt 193 Lys Arg Ser His Ser Ser Pro Ser Gln Ile Pro Lys Lys Ile Leu Ser 50 55 60 cac atg acc cat gaa gta aca gag gat ttt tct cct cgg gat cca aga 241 His Met Thr His Glu Val Thr Glu Asp Phe Ser Pro Arg Asp Pro Arg 65 70 75 80 act gtt gtt ggg aag caa gat ggc agg ggc tgc act tca gtc aca aca 289 Thr Val Val Gly Lys Gln Asp Gly Arg Gly Cys Thr Ser Val Thr Thr 85 90 95 gca ttg tcc cta cct gaa ctg gaa agg gaa gat gga aaa gaa gac att 337 Ala Leu Ser Leu Pro Glu Leu Glu Arg Glu Asp Gly Lys Glu Asp Ile 100 105 11 0 tca gat cct atg gac ccg aac cct tgt agt gca aca tac agc aac tta 385 Ser Asp Pro Met Asp Pro Asn Pro Cys Ser Ala Thr Tyr Ser Asn Leu 115 120 125 ggg caa tct aga gca gcc atg ata cct ccc aag cag cca cga cag ccc 433 Gly Gln Ser Arg Ala Ala Met Ile Pro Pro Lys Gln Pro Arg Gln Pro 130 135 140 aag gga gct gtg gac gat gcc atc gcc ttt gga ggg aaa aca gac caa 481 Lys Gly Ala Val Asp Asp Ala Ile Ala Phe Gly Gly Lys Thr Asp Gln 145 150 155 160 gaa gca ccc aat gct tcc caa cct aca cca ccc cca ctg cca aag aag 529 Glu Ala Pro Asn Ala Ser Gln Pro Thr Pro Pro Pro Leu Pro Lys Lys 165 170 175 atg atc ata aga gcc aat aca gag cca atc tcc aag gac ctc caa aaa 577 Met Ile Ile Arg Ala Asn Thr Glu Pro Ile Ser Lys Asp Leu Gln Lys 180 185 190 tcc atg gaa agt agt ctt tgt gtc atg gct aat ccc acc tat gat atc 625 Ser Met Glu Ser Ser Leu Cys Val Met Ala Asn Pro Thr Tyr Asp Ile 195 200 205 gac ccc aac tgg gat gcc agc agt gct ggt tct tcc atc agc tat gaa 673 Asp Pro Asn Trp Asp Ala Ser Ser Ala Gly Ser Ser Ile Ser Tyr Gl u 210 215 220 ctc aaa gga ctg gac att gag tct tat gac tcc ttg gaa agg cct ttg 721 Leu Lys Gly Leu Asp Ile Glu Ser Tyr Asp Ser Leu Glu Arg Pro Leu 225 230 235 240 cgc aag gag aga cct gtc ccc tca gca aac agc att tcc agc tta 769 Arg Lys Glu Arg Pro Val Pro Ser Ala Ala Asn Ser Ile Ser Ser Leu 245 250 255 acc act ctc agt att aag gat aga ttt tcc aac agc atg gaa tcc ctc 817 Thr Thr Leu Ser Ile Lys Asp Arg Phe Ser Asn Ser Met Glu Ser Leu 260 265 270 tcc agc cgg cgt ggg ccc tct tgc aga cag ggc cga ggc atc cag aag 865 Ser Ser Arg Arg Gly Pro Ser Cys Arg Gln Gly Arg Gly Ile Gln Lys 275 280 285 ccg cag aga caa gca ctt tat cga gga ctt gag aat cgg gag gaa gta 913 Pro Gln Arg Gln Ala Leu Tyr Arg Gly Leu Glu Asn Arg Glu Glu Val 290 295 300 gtg ggt aaa atc cga agc ctt cat aca gat gcc ttg aag gct 961 Val Gly Lys Ile Arg Ser Leu His Thr Asp Ala Leu Lys Lys Leu Ala 305 310 315 320 gtt aaa tgc gaa gac ctt ttc atg gct ggg cag aaa gac cag ctc cgt 1009 Val Lys Cys Glu Asp Leu Phe Met Gla Gln L ys Asp Gln Leu Arg 325 330 335 ttt gga gtg gac agc tgg tca gac ttc agg cta acc agt gac aaa cca 1057 Phe Gly Val Asp Ser Trp Ser Asp Phe Arg Leu Thr Ser Asp Lys Pro 340 345 350 tgt tgt gag gca ggt gat gcg gtt tac tat act gct tca tat gca aaa 1105 Cys Cys Glu Ala Gly Asp Ala Val Tyr Tyr Thr Ala Ser Tyr Ala Lys 355 360 365 gat cca ctt aat aac tat gca gtc aag atc tgt aag agc aaa gct aaa 1153 Asp Pro Leu Asn Asn Tyr Ala Val Lys Ile Cys Lys Ser Lys Ala Lys 370 375 380 gaa tct cag cag tat tat cac agc ttg gct gtc cgg cag agt ctg gct 1201 Glu Ser Gln Gln Tyr Tyr His Ser Leu Ala Val Arg Gln Ser Leu Ala 390 395 400 gtc cat ttt aac att cag cag gac tgt ggt cat ttc ctt gct gaa gtc 1249 Val His Phe Asn Ile Gln Gln Asp Cys Gly His Phe Leu Ala Glu Val 405 410 415 cct aac cgt ctg ctt ccc tgg gag gat ccaat gac cct gaa aag gat 1297 Pro Asn Arg Leu Leu Pro Trp Glu Asp Pro Asp Asp Pro Glu Lys Asp 420 425 430 gag gat gac atg gaa gag act gaa gaa gac gcc aaa gga gaa acg gat 1345 Glu Asp Asp Met Glu Glu Th r Glu Glu Asp Ala Lys Gly Glu Thr Asp 435 440 445 ggg aaa aac cca aag ccc tgt tct gaa gca gca tca tcc cag aaa gag 1393 Gly Lys Asn Pro Lys Pro Cys Ser Glu Ala Ala Ser Ser Gln Lys Glu 450 455 460 aat cag gga gtc atg agc aag aag cag agg agc cac gtt gtg gtc atc 1441 Asn Gln Gly Val Met Ser Lys Lys Gln Arg Ser His Val Val Val Ile 465 470 470 475 480 acc agg gag gtt cca tgt ctt act gtg gct gat ttt gtg cga gac tct 1489 Thr Arg Glu Val Pro Cys Leu Thr Val Ala Asp Phe Val Arg Asp Ser 485 490 495 ctg gcc cag cat ggg aaa agc cct gat ttg tat gag agg cag gtg tgt 1537 Leu Ala Gln His Gly Lys Ser Pro Asp Leu Tyr Glu Arg Gln Val Cys 500 505 510 ctg ctg ctc tta cag cta tgc tct ggt ctt gag cac ctc aaa ccc tac 1585 Leu Leu Leu Leu Gln Leu Cys Ser Gly Leu Glu His Leu Lys Pro Tyr 515 520 525 cat gtc act cac tg cta cgc cta gag aac ctg cta ctt gtc cac 1633 His Val Thr His Cys Asp Leu Arg Leu Glu Asn Leu Leu Leu Val His 530 535 540 tac cag cct ggg ggg act gcc caa ggc ttt ggg cct gca gag ccc agc 1681 Tyr Gl n Pro Gly Gly Thr Ala Gln Gly Phe Gly Pro Ala Glu Pro Ser 545 550 555 560 ccc acc tca tct tat ccc act agg ctt ata gtg agc aac ttc tct cag 1729 Pro Thr Ser Ser Tyr Pro Thr Arg Leu Ile Val Ser Asn Phe Ser Gln 565 570 575 gcc aag cag aag agc cat ctg gtg gac ccc gag atc ctc cgg gac cag 1777 Ala Lys Gln Lys Ser His Leu Val Asp Pro Glu Ile Leu Arg Asp Gln 580 585 590 tct cgc ctt gcc cca gag atc ata gct acc cag tat aaa aag tgt 1825 Ser Arg Leu Ala Pro Glu Ile Ile Thr Ala Thr Gln Tyr Lys Lys Lys Cys 595 600 605 gat gag ttc cag aca ggc atc ctc atc tat gag atg ctg cac cta ccc 1873 Asp Glu Phe Gln Thrly Ile Leu Ile Tyr Glu Met Leu His Leu Pro 610 615 620 aac ccc ttt gat gag aac cca gag ctg aag gag agg gaa tac aca cga 1921 Asn Pro Phe Asp Glu Asn Pro Glu Leu Lys Glu Arg Glu Tyr Thr Arg 625 630 635 640 gca gac ctg cct cgc atc cca ttc cgc tcc ccc tac tcc cgg ggt ctg 1969 Ala Asp Leu Pro Arg Ile Pro Phe Arg Ser Pro Tyr Ser Arg Gly Leu 645 650 655 655 cag cag ctg gcc agc tgc ctc act c gag cgg atc 2017 Gln Gln Leu Ala Ser Cys Leu Leu Asn Pro Asn Pro Ser Glu Arg Ile 660 665 670 ctc att tca gac gcc aaa ggc atc ctc cag tgt ctg ctc tgg ggc ccc 2065 Leu Ile Ser Asp Ala Lys Gly Ile Le Cys Leu Leu Trp Gly Pro 675 680 685 cgc gaa gat ctc ttc cag act ttc acc gcc tgc cct agc cta gta cag 2113 Arg Glu Asp Leu Phe Gln Thr Phe Thr Ala Cys Pro Ser Leu Val Gln 690 695 700 agg aac acc ctg ctg caa aac tgg cta gac atc aag cga aca ctg ctc 2161 Arg Asn Thr Leu Leu Gln Asn Trp Leu Asp Ile Lys Arg Thr Leu Leu 705 710 715 720 atg atc aag ttt gct gag aag tcc ctg gac agg gaa ggt gga atc ag Ile Lys Phe Ala Glu Lys Ser Leu Asp Arg Glu Gly Gly Ile Ser 725 730 735 ctt gag gac tgg ctt tgt gct cag tat ttg gct ttt gcc act aca gac 2257 Leu Glu Asp Trp Leu Cys Ala Gln Tyr Leu Ala Phe Ala Thr Thr Asp 740 745 750 tcc ctc agt tgt att gtg aaa att ctg cag cac cgt taatgtgtac 2303 Ser Leu Ser Cys Ile Val Lys Ile Leu Gln His Arg 755 760 ctggatgatg cttttactact atcttcacct tcttcatgtc acccatgcactt ccctccc 2363 tagtgctcac tccaaattca aggaaagaag aaagacaaac ctctatccct gtccgtgaac 2423 aagtgggtct attcagaaag gttatccact gccccagatt gaatgagaag ctgagtctgt 2483 cttaacttta cagaaattca gctgcacaaa cttgcagttg ccttcccttg aaacaccttc 2543 tatcctaata gtcccataaa tgcaggtaaa aatgaaaatc catattcttg aagggacagc 2603 ttctttggta tgaactcagc cagtgagctg tgtccatttc ctccataatt ctggatatca 2663 cctatctttt tagcaccaag tatttattct cactagcagt agacagactt aaccagtctc 2723 taccacgacc cagtagactc tgacaacaga ctcttccttt aaggtgtcaa caactgactt 2783 actaggcagg actgccatcc ttagcatcag cccagttttg gttaccaggg actatatctt 2843 ttgttccagg agagagtaga aagaaaagga gagatcccat ccttgggtca tagacccatt 2903 ttcattgcca ttatctgtaa gtatgtgcac tgcatggagg acagccctaa tagtctcccc 2963 tctgctgcca ctgcctgatt ctccactctg tccccacttg ccagtgaagt ttggatttat 3023 cagccacttg tggcccatta cagagctgac ccaaggtggt gtcaccaatg cctcagcagg 3083 gtggagtgca gttcagagct tataaatagc tggcagggca tgaggagatg attttcttgc 3143 atgtgcaatt ctctaggggc catcaggaaa cagagtttaa agtacccttt gattactgt c 3203 agaactgtca gcatttgcag ttttccccga gcagtaattg gccagctccc ttctatcagt 3263 agccagtgtt aactagttta ccaaatgctg taaacaattg ccctgaatga aatagctgtc 3323 agtggagctc taagatctcc tttagagggc acagtgaggt gggctgttgg gatggccgta 3383 ggcaggggag aggaagaagg ccactgatga gactgctgac ctcctcagaa tgttgacctc 3443 ttctagagag actgcctccc agtgtttaag tggctcattg ctccttctga ctctgtaaaa 3503 tggctctgga ggacagctca caggaattct gattgctgag gtgggtgatt gagagctgtt 3563 caccatgtgt gcagcctgtg ctccccttct atggatatgt gtgcaatttt tgtatgtatt 3623 tttttagctg tatattacag tgtttatgtt gcaacttcac ctgaagcgag tctacagaaa 3683 ccctccccct tcttcccttg gcacatattt gcgctaagag atgagcgttc cttccactgg 3743 ggttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgtatac acatgttcac 3803 ctgtgcttgt tttattcaaa actgtgagta tgtgtttact ttgaccttga aatcccaaga 3863 gtcactcgaa caatgtgtgt gtacacttgt gtgcccatgt gtgcgtgcac acgcatgctg 3923 gaagtagagg ccaggcctct agaaaagcaa cctgtggcag ggttgacaga catgttctct 3983 gtgcctagtg agtgagtgag ccctgaggcc cctcatctac cagtgcagag tttccttaaa 4043 gccaagactg actgtgcagt attacttaca tagcacatta gtggccttgg aaatttctaa 4103 acttttaaca tttttaacag cttttcatgt gattcatgta tatcaaagag gatcaggaaa 4163 ggaaaataat gtattttatt gtgctcttat tactttttta agtgattgta atatgtgagg 4223 ctctatttgg agaatgtccc ttatcccctg gccagcaata taggactcac aggaaagaag 4283 gctggttagc ccacaaagag tcttgcctcc tctagccaga gtgcagggct ctgctcctag 4343 gaatggccat ggagtgggca tgctgctgca ggccagcagt ctgctcttgg tgtcctgtgg 4403 catggccgcg ccttgccttg aaggttggtg tttggttcat cttagcatag aacatgtgca 4463 cataactcct tgcctgatta tgcactgaag ggcagcacac agaccactga ccatgtcagc 4523 cagcacattc ccttaacctc ccccacctcc catcttgcaa tgtcttgcat attgagatat 4583 accttctcaa tgtcatgttc gtggtgcctt gcccatgtaa atttgaatgt tgactattta 4643 atgaggttac atatttaatg ctgaatgttt cctggtccct ctatttgtta tgtctctact 4703 tatctttttt tttctttctc tttttctgtt atgatttgga tccagtcttc actttaactc 4763 tatggtataa taagcatgga cacctccact accattatct tacagcactg gtaaaccaag 4823 cacctcttca tatcagatgt ttttagtact gtttttatat tcagatttgt taagggcaaa 4883 agat gaatgc aaactagcca gagaaaagcc tcaggcttcc cagagacagg tggctagatt 4943 aatttttctc tgggtgatgg ccaaagaatg tgagatagag agggaagggg gtgttacagg 5003 ttagagcaga atagagaaag aaactatatt tctaagcaaa aagtactaca tgagttggtc 5063 ttcagaatat ttttccaaaa aaatgaaatt cagtcagttt aacattatca caaatatttt 5123 tcattttaat tgtggtagga cctttgaatt tgttcatcaa ctggaaagaa atcctaccct 5183 ctgtagacac atacacacac atttatatat ctatgtgttt gaattgtgac tagtatagca 5243 ctttacattt tctcaagtaa caggaagtta ttgccttcaa tattgattgg aaattgtttt 5303 ctattgaagt ctatactgta gagttttcca tttatattga gagtttgaac aattaagctc 5363 ctattggaac ttttccttaa gccacatgag catgaacaat ctctgtgaca cttgggtgct 5423 agagaaacac aacagtggct aaagtagcca agagcaagac tgaatgtata gcagagtgcc 5483 ttgttagagt ggtaacctag tcttggaagc aattcagtgg atgtttcata aagaggacta 5543 gaacttcaag aagcctcctg tgctggctga ggtgagccct tttggtatat gtacactact 5603 gggttgccta gaagccaatt catgaagaat aacagcagga tgagaaaaag agtcactgta 5663 acctgtggaa caacaacgta agaatcacca acccctaggc tgagctagaa ctggaagcca 5723 ggaatatggc aatgagtttc aagatttgcc ctcagaagat gaactgggtg aggtatgggt 5783 tgaggtgagg gcacaagcac tcatcctacc taccctgctg ctgttgagga gctagaagta 5843 aaacatattg gttaggattt taacagttgg agtagcctcc cattatcaga ttaagtgggg 5903 gtcacttttg cttccaaact cagaataagt ttgtaaacat gggaaagtct aagccaagag 5963 atctaaagct ctagaaatat taatgacatt tctgggagta aaactactaa aaattatatc 6023 ttaaaagttt ctagtagtat aaagttccca ggccaggcgc agtggctcac gcctgtaatc 6083 ccaacacttt aggagggcga ggtgggcaga tcacctgagg tcaggagttt gagaccagcc 6143 tggccaacat ggtgaaactc catctctact aaaaatacaa aaattagccg ggcatgatgg 6203 caggcacctg taatctaagc tactcgggag gctgaggcaa gagaatctct tgaacccagg 6263 aggcaaaggt tgcagtgagc caagatcacg ccatcgcact ccagcctggg agattgagca 6323 acttcgtctc aaaaaaaagt ttccaggaaa gatctttggg tcctactaag cgtctcaatt 6383 ttgagttatg aatactttgg ttcagggaag taacctgaca tttggttttg ctggaattag 6443 ggttttcgct agatttgact gcaattagga tttcttctag attttaccag cagtgatctg 6503 aaaaagtaca ggctagtcac agaaatagag atggatttag gatactacac tatatttcaa 6563 atgattctag atgtg taaat atagtatgaa cattcttgga gaggggtgag acaaactgga 6623 cttgctgggc caaccctggc atgtttttca ttctcctcac tagttgacaa ggattgaaaa 6683 ttccgctcca gcctaatgag tgaacaggat ggctgcccac aaaaccaagt tattagcttt 6743 atgtcatcga agctcatatt ctcaaaggcc caaagtgctg tgccgagaca aatccaagtg 6803 ctgctcttgc tgaagtgcgc actgaagtcc agctgtccgt gcttacagca gtgccaaaag 6863 tggggattcc atggaccaaa aacggtgcca taagggaagc cagaagagtt gcagtgcaag 6923 atcctgggag agattatacc aaagaaatca agccttttta tcctgatgct tctaagatga 6983 tgagggtgag ctgtgacaga tgctgtggga ggggagttca catacattcc atgtcaaggc 7043 atttagctga taaatccatc ctcagaaaag caccttttta aaaagaagtc cattttgtat 7103 attagaagat gatgatgatg atgaagatga agaaagccct ggcagataca aagttcctca 7163 gtatttaagg agaaggatct cttccatgtc cccttgacat gactgtggct attgcccaaa 7223 cctcagcttg agaacatcat ataatactga gagcggaaga tttttttaaa gagatatggt 7283 agtttaaata ggtttgttta aagaactctt gggaaatttc ttaacaaatt gtaattgttt 7343 ttataaacct tcctacagag ttgtgtacca ttcatcatca ccatcattta atatctgtaa 7403 gtgcccagaa ggtacaaggt gctatacagc cgttaaacac cccctccctg caactgttta 7463 aaattagaat agatttttgc atcaaccact gctagaagct ttccccacct aggtgggctg 7523 caagggcctg cattcccaac atcccattac atgtttccca ctccagaaag tctctgggtt 7583 tattccagct ttttatcttg acgtgtccca ttcaccccca tggtttggtt tggtttggtt 7643 ttgtttttta aatcaagaaa gtttcaggga atcaaaagag gtcggacatt ttttaaccta 7703 gcagaagtac agagtcatat attttgctac gaatattgtt gtagtacaga aaacccactt 7763 tgcccgttag tgtgtggata gtatgtgtgt gtccgcactc atgataactt gaatgttgaa 7823 ccagacatag ggttcatttt tgaaaggtta aaccacactg tttcaggaac ttgctccaaa 7883 tactacttgg ttatcccttc ctttaccagt tagaactaaa gagtgtgatg tatgaacaca 7943 ctgggttggg attttctgtt gaggatatgc agggcatttt ggcatgaggc aaatacagaa 8003 gcaagatttc attctacttg gtgatttgaa tcatgacagt cctcattcca atctctcttt 8063 aattctctct ggccctgccc acactctgta tttgaaaatc ttgtttttgc tctttccgga 8123 gcttcacccc tctacttaca tattgtaaag ttgtataaat ctatcattga aaggtcccct 8183 ctgccagcag tggtgccacc ctttggtttg ctgtggtact ttgctgtgta ctccgtggca 8243 tcatgttact gtgtaaataa attca tttta atacacact 8282 <210> 6 <211> 7784 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1981) .. (4077) <400> 6 ctgccccgcc ccgtcccgtt ccgttcctct gccccacccc gtcccgttcc gttccgctgc 60 ccagtcctgc tggtactcac taggtagtag cggcaacgga cgccatgggg accgcctcgt 120 cgctcgtgag ccccgcgggc ggggaagtga tcgaggacac gtacggggcg ggcggcggcg 180 aggcctgcga gatcccggtg gaggtgaagc ccaaggcccg cctgctgcgc aactcgttcc 240 gccgaggcgc gggggcggca gcaggggccg ggcccgggtc gctgccccgc ggggtgggcg 300 cgggcgggct gctgggggcc agcttcaagt ccactggctc gtcggtgcca gagctggagt 360 acgcggcggc cgagtacgag cggctcagga aggagtacga gatctttcgc gtcagcaaga 420 accaggagtt gttgtccatg ggccgccgcg aggccaagct ggacacggag aacaagcggc 480 tgcgggccga actgcaggca cttcaaaaaa cgtatcagaa gatacttcga gaaaaagaaa 540 gtgctttaga agcgaaatac caagcaatgg agagagcagc aacatttgaa catgacagag 600 ataaagttaa aaggcaattc aagattttta gggagaccaa agaaaatgaa attcaggact 660 tactgagggc caagagggag ttggagagca aacttcagag gctacaggct cagggtatcc 720 aagtatttga tcctggggag tctgattcag atgacaactg tacagatgtc actgctgctg 780 gaacccaatg tgaatattgg actggcggag ccttgggaag tgaaccttcc ataggaagca 840 tgatccagct tc agcagtcc ttcagaggcc ctgagtttgc ccatagttct atagatgtgg 900 aaggaccctt tgcaaatgtt aatagagatg actgggatat tgctgtagct agtttattac 960 aagttactcc tctgttttca cattctctgt ggagtaacac tgtcagatgt tacctcattt 1020 atacagatga aacccagcct gagatggatc ttttccttaa ggactattca cctaaactta 1080 agagaatgtg cgagacaatg ggatattttt tccatgctgt ttattttcca atagatgttg 1140 aaaatcaata cctcactgta agaaaatggg aaattgagaa aagttcttta gttattttat 1200 ttattcactt aacattacca agccttttat tggaagactg tgaagaagct tttctgaaaa 1260 accctgaagg aaaacctcga ttaatctttc atcgtttgga agatggaaaa gtcagttctg 1320 actctgtcca gcaattgatt gatcaagttt ctaatctaaa caagaccagc aaagccaaga 1380 tcattgatca ctcaggagat cctgcagaag gagtatataa aacttatatt tgtgtagaaa 1440 agattattaa acaggacata ctgggttttg agaacacaga cttggagact aaggatttgg 1500 gcagtgagga ttccattcca gaagaagatg attttggtga tgttctgtgg gacatacatg 1560 atgaacaaga gcaaatggaa acttttcagc aggcttctaa ttcagcccat gagttgggat 1620 ttgagaaata ttaccaacgc cttaatgatc tagtggcagc accagccccg attccacctc 1680 ttctcgtgtc tggaggacc a ggttctggga agtctcttct tttatcaaag tggattcaat 1740 tacaacagaa gaattccccc aacacactga ttctttccca ttttgtggga aggcccatgt 1800 caaccagctc agagtcctcc ttgattatta aacgactaac tctaaagttg atgcagcact 1860 cttggtcagt ctctgctctg acactggatc ctgctaagct tctggaagaa tttccacgtt 1920 ggctggaaaa actctctgct cgtcatcaag gcagcatcat catcgttatt gattctatag 1980 atc aag ttc agg ttg tgg cct aca ctt cat ctt gat ccc tta agt cca 2028 Ile Lys Phe Arg Leu Trp Pro Thr Leu His Leu Asp Pro Leu Ser Pro 1 5 10 15 aaa gat gca aaa tct att ata att gca gaa tgc cac tct gta gac att 2076 Lys Asp Ala Lys Ser Ile Ile Ile Ala Glu Cys His Ser Val Asp Ile 20 25 30 aaa ttg agt aaa gag cag gag aag aag cta gaa cga cac tgt cgt tct 2124 Lys Leu Ser Lys Glu Gln Glu Lys Lys Leu Glu Arg His Cys Arg Ser 35 40 45 gct aca acc tgc aat gcc ctt tat gtc acc ctt ttc ggc aaa atg atc 2172 Ala Thr Thr Cys Asn Ala Leu Tyr Val Thr Leu Phe Gly Lys Met Ile 50 55 60 gcg cgt gct ggg aga gca ggc aat tta gat aaa atc ctt cat cag tgt 2220 Ala Arg Ala Gly Arg Ala Gl y Asn Leu Asp Lys Ile Leu His Gln Cys 65 70 75 80 ttc cag tgt caa gat act ctt tca tta tat aga ctt gtt ctg cac tct 2268 Phe Gln Cys Gln Asp Thr Leu Ser Leu Tyr Arg Leu Val Leu His Ser 85 90 95 atc cgg gag tcc atg gca aat gat gtg gat aaa gag cta atg aag cag 2316 Ile Arg Glu Ser Met Ala Asn Asp Val Asp Lys Glu Leu Met Lys Gln 100 105 110 atc ctc tgc ctt gtc aat gtt agt cac aat ggt gtg agt tca gaa 2364 Ile Leu Cys Leu Val Asn Val Ser His Asn Gly Val Ser Glu Ser Glu 115 120 125 ctg atg gaa ctc tat cct gag atg tcc tgg act ttc ttg acc tcc ctt 2412 Leu Met Glu Leu Tyr Pro Glu Met Ser Trp Thr Phe Leu Thr Ser Leu 130 135 140 att cac agt tta tac aaa atg tgt ttg ttg act tat gga tgt ggc ttg 2460 Ile His Ser Leu Tyr Lys Met Cys Leu Leu Thr Tyr Gly Cys Gly Leu 145 150 155 160 ctt agg ttt caa cat ctg cag gct tgg gaa aca gtg aga ttg gag tac 2508 Leu Arg Phe Gln His Leu Gln Ala Trp Glu Thr Val Arg Leu Glu Tyr 165 170 175 ctg gaa ggc ccc act gtt act tct tca tac agg caa aag cta atc aac556 Gl y Pro Thr Val Thr Ser Ser Tyr Arg Gln Lys Leu Ile Asn 180 185 190 tat ttc acc ttg cag cta agt cag gac aga gtg act tgg aga agt gca 2604 Tyr Phe Thr Leu Gln Leu Ser Gln Asp Arg Val Thr Trp Arg Ser Ala 195 200 205 gat gaa ctc ccg tgg ctt ttt cag cag cag gga agt aaa cag aag ctg 2652 Asp Glu Leu Pro Trp Leu Phe Gln Gln Gln Gly Ser Lys Gln Lys Leu 210 215 220 cat gat tgc ctt ctt aat ctc ttt gtg tct aac ctt tat aaa agg 2700 His Asp Cys Leu Leu Asn Leu Phe Val Ser Gln Asn Leu Tyr Lys Arg 225 230 235 240 gga cac ttt gct gag ttg ctg agt tat tgg cag ttt gtt ggc aaa gac 2748 Gly His Phe Ala Glu Leu Leu Ser Tyr Trp Gln Phe Val Gly Lys Asp 245 250 255 aaa agt gca atg gca aca gaa tac ttc gat tca ttg aag cag tat gag 2796 Lys Ser Ala Met Ala Thr Glu Tyr Phe Asp Ser Leu Lys Gln Tyr Glu 260 265 270 270 aaa aac tgc gaa ggc gag gac aac atg agt tgc tta gct gat ctt tat 2844 Lys Asn Cys Glu Gly Glu Asp Asn Met Ser Cys Leu Ala Asp Leu Tyr 275 280 285 gaa acc ttg ggg cga ttt ctc aag gat cta ggc ctt gcc 2892 Glu Thr Leu Gly Arg Phe Leu Lys Asp Leu Gly Leu Leu Ser Gln Ala 290 295 300 ata gta cct ttg cag agg tct tta gag att cga gaa aca gct tta gat 2940 Ile Val Pro Leu Gln Arg Ser Leu Glu Ile Arg Glu Thr Ala Leu Asp 305 310 315 320 ccc gat cac cca aga gta gcc cag tcc ctc cac caa cta gca agt gta 2988 Pro Asp His Pro Arg Val Ala Gln Ser Leu His Gln Leu Ala Ser Val 325 330 335 tac gtg cag tgg aag aag ttt ggc aat gca gaa caa ctg tat aaa cag 3036 Tyr Val Gln Trp Lys Lys Phe Gly Asn Ala Glu Gln Leu Tyr Lys Gln 340 345 350 gcg ttg gaa atc tca gaa aat gct tat ggt gcg gac cat cca tat act 84 Ile Ser Glu Asn Ala Tyr Gly Ala Asp His Pro Tyr Thr 355 360 365 gct cgt gaa ctt gaa gca ctt gca act ttg tac cag aaa caa aat aaa 3132 Ala Arg Glu Leu Glu Ala Leu Ala Thr Leu Tyr Gln Lys Gln Asn Lys 370 375 380 tat gaa caa gct gaa cat ttt agg aaa aaa tcc ttt aaa att cat cag 3180 Tyr Glu Gln Ala Glu His Phe Arg Lys Lys Ser Phe Lys Ile His Gln 385 390 395 400 aaa gct ata aag aaa aaa ggc aac ttg tac gga ttt gcc ctt tta cgt 3228 Lys Ala Ile Lys Lys Lys Gly Asn Leu Tyr Gly Phe Ala Leu Leu Arg 405 410 415 aga cgg gct tta cag tta gaa gag ctt aca tta ggt aag gac aca cct 3276 Arg Arg Ala Leu Gln Glu Glu Leu Thr Leu Gly Lys Asp Thr Pro 420 425 430 gat aat gct cgg acc ctc aat gaa ctg ggt gtt ctc tac tat ctt caa 3324 Asp Asn Ala Arg Thr Leu Asn Glu Leu Gly Val Leu Tyr Tyr Leu Gln 435 440 445 aat aac ctg gaa aca gct gac cag ttt ctg aag cgt tcc tta gaa atg 3372 Asn Asn Leu Glu Thr Ala Asp Gln Phe Leu Lys Arg Ser Leu Glu Met 450 455 460 agg gag cga gtt cta gga cca gat cac cct gac tgt gct ttg 3420 Arg Glu Arg Val Leu Gly Pro Asp His Pro Asp Cys Ala Gln Ser Leu 465 470 475 480 aat aat ctg gca gct cta tgc aat gaa aag aaa cag tat gat aaa gca 3468 Asn Asn Leu Ala Ala Leu Cys Asn Glu Lys Gln Tyr Asp Lys Ala 485 490 495 gaa gaa ctt tat gaa aga gct tta gat att cgg aga cgt gca tta gct 3516 Glu Glu Leu Tyr Glu Arg Ala Leu Asp Ile Arg Arg Arg Ala Leu Ala 500 505 510 cct gat cac ct ttg gca tat acg gtg aag cat ctt gcc atc ttg 3564 Pro Asp His Pro Ser Leu Ala Tyr Thr Val Lys His Leu Ala Ile Leu 515 520 525 tat aag aaa atg ggg aaa ctt gac aaa gct gta cct ttg tat gaa ttg 3612 Tyr Lys Lys Met Gly Lys Leu Asp Lys Ala Val Pro Leu Tyr Glu Leu 530 535 540 gct gtt gaa att cga cag aaa tct ttt ggc cca aag cac cct agt gta 3660 Ala Val Glu Ile Arg Gln Lys Ser Phe Gly Pro Lys His Pro Ser Val 545 550 555 560 gct act gcc ttg gtg aac tta gct gtt ctt tat agc caa atg aaa aaa 3708 Ala Thr Ala Leu Val Asn Leu Ala Val Leu Tyr Ser Gln Met Lys Lys 565 570 575 cac gtt gaa gct ttg cca ttatat aga gca tta aag att tat gaa 3756 His Val Glu Ala Leu Pro Leu Tyr Glu Arg Ala Leu Lys Ile Tyr Glu 580 585 590 gat agc ctg ggt cgg atg cat cct cga gtt gga gaa aca ctg aaa aat 3804 Asp Ser Leu Gly Arg His Pro Arg Val Gly Glu Thr Leu Lys Asn 595 600 605 tta gct gtg ctt agc tat gaa gga gga gat ttt gaa aaa gct gct gaa 3852 Leu Ala Val Leu Ser Tyr Glu Gly Gly Asp Phe Glu Lys Ala Ala Glu 610 615 6 20 tta tac aaa agg gca atg gaa ata aaa gaa gca gaa aca tca ctc ttg 3900 Leu Tyr Lys Arg Ala Met Glu Ile Lys Glu Alu Glu Thr Ser Leu Leu 625 630 635 635 640 ggt gga aaa gct cct tca cggt cat tca tca gac acg ttt agc 3948 Gly Gly Lys Ala Pro Ser Arg His Ser Ser Ser Gly Asp Thr Phe Ser 645 650 655 tta aaa aca gct cat tct cct aat gtt ttc ctt cag caa gga caa agg 3996 Leu Lys Thr Ala His Ser Pro Asn Val Phe Leu Gln Gln Gly Gln Arg 660 665 670 aaa gtc caa tcc aac ctt tta tct cca gaa ggg ctt tca aac ata tgt 4044 Lys Val Gln Ser Asn Leu Leu Ser Pro Glu Gly Leu Ser Asn Ile Cys 675 680 685 gct cag gaa aaa acc acc agg ttc act tct tcc taaagcacat cagattgata 4097 Ala Gln Glu Lys Thr Thr Arg Phe Thr Ser Ser 690 695 gagaatttaa agtccagaaa gccttgtttt caattggatt ccccgttccc aagcctatac 4157 tgtactgcag tgatacttct gtcattggaa cagaatttta cgtaatggaa catgtgcagg 4217 gtcgaatctt ccgtgattta acaattcctg gacttagccc agcagaacgt tcagccatat 4277 atgtggccac ggtagaaaca ttggctcagt tacattcctt gaatatacag tcactgcagc 4337 tggaag gata tggtataggt gctgggtact gcaaaagaca ggtatcaacc tggacaaagc 4397 aatatcaagc tgcagctcat caggacatcc ctgccatgca acagctatcg gagtggctaa 4457 tgaagaactt gcctgataat gacaatgaag agaatttgat tcatggagat ttcagactag 4517 ataacatagt tttccaccct aaagagtgtc gagttatagc agtgctggat tgggagctgt 4577 caaccattgg tcatcctttg tcagacttag ctcatttttc cctgttctac ttttggccaa 4637 ggacagttcc aatgataaat caaggttctt atagtgaaaa ctcagggata ccatcaatgg 4697 aagaactgat ttcaatatat tgccgctgca ggggaattaa ttctattctt cctaactgga 4757 atttctttct tgccctttca tattttaaga tggctggaat agcacaggga gtatatagca 4817 gatatcttct gggaaataat tcatctgagg atagcttttt atttgccaat attgtgcaac 4877 ctctggcaga aactggacta caactctcca aacgaacttt cagtactgta ctaccacaga 4937 ttgatactac tggacagttg tttgtacaga ctcggaaagg tcaggaagtt cttattaagg 4997 tgaagcattt catgaaacaa cacattcttc cagctgaaaa gattatgaga ctgatgcact 5057 gccctactgc gctaaggagg caacctcctc tttctaagag cttttctttc tctttaatgt 5117 tctgtagttt tactatgctc tggcttcatt ggctttccga atttgaggat tgctgtctta 5177 tcagttccga aaacttttaa gagaggtaac tgagttctat gttcaaaatg aaaattcagt 5237 ggacacgtgg ggaaaacctt tagtgattga taaactcaag gaaatggcca aagtcgaggg 5297 tctctggaac ttgtttttgc cagctgtcag cggactcagc cacgtggact atgccttgat 5357 tgctgaagaa acaggaaaat gcttttttgc tccagatgtc tttaactgcc aagcaccaga 5417 cacagggaat atggaggttc tgcacctgta tggaagtgag gaacagaaga aacagtggct 5477 tgagcctctt cttcaaggga acattacctc ttgcttctgt atgacagaac ctgatgtagc 5537 ttcaagtgat gccacgaata ttgaatgcag catccaacga gatgaagata gctatgtaat 5597 taacggcaaa aaatggtgga gcagtggagc tgggaatccc aagtgcaaaa ttgcaattgt 5657 tttgggaaga actcaaaata cttctctctc caggtaatta aacaattctg attgagaaac 5717 ctgtgtagga atgagccagt cttcctccta tctaggtaat ttacttaaaa ttcactgttt 5777 ggactcacaa atcataatgt aagatatgag agtaaatgtc atatatttgt atttcacaag 5837 tattttctaa caggtgtttt tggaaaacat tatagggagt attgctgaac attcttcgct 5897 gtggaatttt cagtattaga aagtgttgct aaattatcaa agctgtttgg attaaattat 5957 cagacaaatt ttttcagacc tgtgtaatga agtgattaga tgtttagatc aaaggcaata 6017 atcttgaaat gtttaa ttat atatataagt tcccagttac cattgttgag cagtgagaag 6077 cttcaatcaa acaactcatt tattttcaaa tcattgtttc tgttccagat cacagcctgc 6137 atcagactat gttggtgtac gtcttttaca cagttcccat tccagtcatc actgcttaca 6197 tgactacatg aaaacatcaa aaagacaatt gtgattctgc ttattatctg ttttattttt 6257 cttcttagca aactttttct aatacaattt ttcttttgac tagacacaaa cagcacagca 6317 tgattcttgt tcccacgaac acacctggag taaaaataat aaggcctttg tcagtttttg 6377 gctacacaga taattttcat ggaggacatt ttgagatcca ttttaatcaa gtgcgagttc 6437 ctgccacaaa tctaatacta ggtgaaggta ggggatttga aatttcccaa ggccgccttg 6497 gacctggcag aatccaccac tgtatgagaa cagtaggttt ggcggaacgc gctttgcaga 6557 tcatgtgtga gcgggcaaca caaaggatag ctttcaagaa gaagttgtat gcacatgagg 6617 ttgtggctca ctggattgct gaaagccgca ttgccattga gaagatccgc ttgttgactc 6677 tgaaagctgc tcacagcatg gacactctgg gcagtgctgg cgctaagaaa gagattgcaa 6737 tgatcaaagt ggctgcccca cgggctgtca gcaaaatcgt tgactgggcc atccaggtgt 6797 gcggaggtgc tggtgtttcc caggattacc ctctggctaa catgtatgct ataacccgag 6857 ttttgcgttt agcagatgga c ctgacgaag ttcatctttc agcaattgca acaatggagc 6917 tgcgggacca agccaaaaga ctgacagcca agatataagg agggtggcac tgccacatcc 6977 cactggcaga aactctcctt tatacaaact tcattggctc caacatttga atctcatatt 7037 tttgtagcag tttgagcaca gggttaatta ttcatttgtg gtaaagatta tagcatctat 7097 tttgatcagt gggttttatt atttcaaggg tcacacaggg ttaagttcag taagaaatgc 7157 tgtagctgtt gtcattcaat ctagtgcctc cttgaggcca ggagttcagg accagcctgg 7217 gcaacatagc gagaccccca ttgctacaaa aaatttaaaa atgaaacaag tgtggtggca 7277 catgcttgta gtcctagcta cttgggaggc tgaggcagga ggattgcttg agtctaggag 7337 tttgaggtta cagtaagctg tgatcgtgac atggcctcca gcctgggtga ccgagtgaga 7397 ctgtttctaa aaataaaaac aaaaaataaa tttcttcttg aggtggggtg gaggtgggga 7457 gcaagaattt gacctggctc tgatccctgg tgtgttgtgt gggcctcttt aacgtttgcc 7517 actgagcctt aacctcactg tacttcactg tacttcacac gcattggtgt taacatttta 7577 atcttagaag accctgaccc actgagggtt tgttgtgaga attgctgaag ccacgtagaa 7637 gcaccttgaa atctgtaaaa ccacaagaaa gtactttata aaaggtatcc ttatttgaag 7697 tggataaatc ttgtaactcg aaaagtt gtg atttagaaga caggattgtt tttgaacatt 7757 aggaattaaa ggctatatct ggtcctt 7784 <210> 7 <211> 8232 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1473) .. (3845) <400> 7 ggcaaacaca attcttcctc attcacatag ccatcattta cactgcttgc caaccctaat 60 gaatatggct gcatcctttg atatccccaa ggaaaagaga ctgcgagcca gtgcagcctt 120 gaactgttta aaacgcttcc atgaaatgaa gaaacgagga cctaagcctt atagtcttca 180 tttagaccac attattcaga aagcaattgc aacacaccag aaacgggatc agtatctccg 240 agttcagaaa gatatattta tccttaagga tacagaggaa gctcttttaa ttaaccttag 300 agatagccaa gtccttcaac ataaagagaa tcttgaatgg aattggaatc ttatagggac 360 cattcttaag tggccaaatg taaatctaag aaactataaa gatgaacagt tacacaggtt 420 tgtacgaaga ctactttatt tttacaagcc cagcagtaaa ttatatgcca acctggatct 480 ggattttgcc aaggccaaac agctcacggt tgtaggttgc cagtttacag aatttcttct 540 tgaatctgaa gaggatgggc aaggctactt agaagatcta gtaaaggata ttgttcagtg 600 gctcaatgct tcatctggaa tgaaacccga aagaagtctt caaaataatg gtttattgac 660 cacccttagt caacactact ttttatttat tggaacactt tcttgccacc ctcatggagt 720 taaaatgctg gaaaaatgca gtgtatttca gtgtctcctt aatctttgct ccttgaaaaa 780 ccaagatcac ttgctaaaac ttactgtttc tagcttggac tatagcagag atggattggc 840 tagagtcatc ct ttccaaaa ttttaactgc agctactgat gcctgcagac tctatgcaac 900 aaaacattta agggtattat tgagagctaa tgttgaattc tttaataatt ggggaattga 960 gttgttagtg acccagctac atgataaaaa caaaacgatt tcctctgaag ctcttgatat 1020 cctcgatgaa gcatgtgaag acaaggccaa tcttcatgct ctcattcaga tgaaaccagc 1080 gttatcccac cttggagaca agggtttgct tctcctgctg agatttctct ccattccaaa 1140 aggattttcc tatctgaatg aaagaggtta tgtagcaaaa caattggaaa agtggcacag 1200 ggaatacaac tccaaatatg ttgacttgat tgaggaacaa ctcaatgaag cacttactac 1260 ttaccggaag cctgttgatg gtgataacta tgttcgtcgg agtaaccaaa gattacagcg 1320 tcctcacgtc tacctgccta tacaccttta tggacaacta gtacaccata aaacaggctg 1380 ccatttgttg gaagtacaga atattattac agaactctgt cgtaatgttc gtacaccaga 1440 tttggataag tgggaagaaa ttaaaaaact ga aag cat ctc ttt ggg cct tgg 1493 Lys His Leu Phe Gly Pro Trp 1 5 ttt gta ata aac act tct gga aat atc ggc tca tca aat tgg ggt ctc 1541 Phe Val Ile Asn Thr Ser Gly Asn Ile Gly Ser Ser Asn Trp Gly Leu 10 15 20 aat ttg cta cag gaa gaa aac gtg att cca gat ata cta aaa ctt gc a 1589 Asn Leu Leu Gln Glu Glu Asn Val Ile Pro Asp Ile Leu Lys Leu Ala 25 30 35 aaa cag tgt gaa gtt ctt tcc atc aga ggg acc tgt gta tat gta ctt 1637 Lys Gln Cys Glu Val Leu Ser Ile Arg Gly Thr Cys Val Tyr Val Leu 40 45 50 55 ggg ctc ata gct aaa acc aaa caa ggc tgt gat att cta aaa tgt cac 1685 Gly Leu Ile Ala Lys Thr Lys Gln Gly Cys Asp Ile Leu Lys Cys His 60 65 70 aac tgg gat gct gtg agg cat agt cgc aaa cat ctg tgg cca gtg gtt 1733 Asn Trp Asp Ala Val Arg His Ser Arg Lys His Leu Trp Pro Val Val 75 80 85 cca gat gat gtg gaa caa ctc tgt aat gaa ctt tca tct atc cca agc 1781 Pro Asp Asp Val Glu Gln Leu Cys Asn Glu Leu Ser Ser Ile Pro Ser 90 95 100 act cta agt ttg aac tcg gag tca acc agc tct aga cat aat agt gaa 1829 Thr Leu Ser Leu Asn Ser Glu Ser Thr Ser Ser Arg His Asn Ser Glu 105 110 115 agt gaa tct gtg cca tcg agt atg ttc ata ttg gag gat gac cgg ttt 1877 Ser Glu Ser Val Pro Ser Ser Met Phe Ile Leu Glu Asp Asp Arg Phe 120 125 130 135 ggc agc agc tct act agt aca ttt ttc ctt gat atc aat ga a gat aca 1925 Gly Ser Ser Ser Thr Ser Thr Phe Phe Leu Asp Ile Asn Glu Asp Thr 140 145 150 gag cca aca ttt tat gac cga tct gga ccc ata aag gat aaa aat tca 1973 Glu Pro Thr Phe Tyr Asp Arg Ser Gly Pro Ile Lys Asp Lys Asn Ser 155 160 165 ttc cct ttc ttt gct tct agt aaa ctt gtg aag aat cgt atc tta aat 2021 Phe Pro Phe Phe Ala Ser Ser Lys Leu Val Lys Asn Arg Ile Leu Asn 170 175 180 tcg ctt act ttg cct aac aaa aaa cat cgt agt agc agt gat cca aaa 2069 Ser Leu Thr Leu Pro Asn Lys Lys His Arg Ser Ser Ser Asp Pro Lys 185 190 195 gga ggg aaa tta tca tct gaa agt aag aca agc aac agg cga atc aga 2117 Gly Gly Lys Leu Ser Ser Glu Ser Lys Thr Ser Asn Arg Arg Ile Arg 200 205 210 215 aca ctt acg gag ccc agt gtt gat ttt aat cat agt gat gat ttt aca 2165 Thr Leu Thr Glu Pro Ser Val Asp Phe Asn His Ser Asp Asp Phe Thr 220 225 230 ccc ata tcc act gta cag aaa aca tta caa tta gag act tca ttt atg 2213 Pro Ile Ser Thr Val Gln Lys Thr Leu Gln Leu Glu Thr Ser Phe Met 235 240 245 ggg aat aag cac att gaa gac act ggt agt aca cca agc att gga gaa 2261 Gly Asn Lys His Ile Glu Asp Thr Gly Ser Thr Pro Ser Ile Gly Glu 250 255 260 aat gac tta aaa ttc acc aag aat ttt ggt aca gag aat cac aga gaa 2309 Asn Asp Leu Lys Phe Thr Lys Asn Phe Gly Thr Glu Asn His Arg Glu 265 270 275 aat aca agc cga gag agg tta gta gta gaa agt tca acg agc tca cat 2357 Asn Thr Ser Arg Glu Arg Leu Val Val Glu Ser Ser Thr Ser Ser His 280 285 290 290 295 atg aag ata cgt agc caa agt ttc aat aca gac act aca aca agt ggc 2405 Met Lys Ile Arg Ser Gln Ser Phe Asn Thr Asp Thr Thr Thr Ser Gly 300 305 310 ata agt tca atg agc tca agt cct tca cga gag aca gta ggt gta gat 2453 Ile Ser Ser Met Ser Ser Ser Pro Ser Arg Glu Thr Val Gly Val Asp 315 320 325 gct aca act atg gac aca gac tgt gga ag atg agt act gtg gta agt 2501 Ala Thr Thr Met Asp Thr Asp Cys Gly Ser Met Ser Thr Val Val Ser 330 335 340 act aaa act att aag aca agc cac tat ttg acg cca cag tct aac cat 2549 Thr Lys Thr Ile Lys Thr Ser His Tyr Leu Thr Pro Gln Ser Asn His 345 350 355 ctg tct ctc tcc aaa tca aat tcg gtg tcc ctg gtg cct cca ggt tct 2597 Leu Ser Leu Ser Lys Ser Asn Ser Val Ser Leu Val Pro Pro Gly Ser 360 365 370 375 tct cat acg ctt cct aga aga gca cag tcc ctt aaa gca ccc tct att 2645 Ser His Thr Leu Pro Arg Arg Ala Gln Ser Leu Lys Ala Pro Ser Ile 380 385 390 gct aca att aaa agt cta gca gat tgt aac ttt agt tac aca agt tct 2693 Ala Thr Ile Lys Ser Leu Ala Asp Cys Asn Phe Ser Tyr Thr Ser Ser 395 400 405 aga gat gct ttt ggc tat gct aca ctg aaa aga cta cag caa caa aga 2741 Arg Asp Ala Phe Gly Tyr Ala Thr Leu Lys Arg Leu Gln Gln Gln Arg 410 415 420 atg cat cca tcc tta tct cac tct gaa gct ttg gca tct cca gca aaa 2789 Met His Pro Ser Leu Ser His Ser Glu Ala Leu Ala Ser Pro Ala Lys 425 430 435 gat gtg cta ttt act gat acc atc acc atg aag gcc aac agt ttt gag 2837 Asp Val Leu Phe Thr Asp Thr Ile Thr Met Lys Ala Asn Ser Phe Glu 440 445 450 455 tcc aga tta aca cca agc agg ttc atg aaa gcc tta agt tat gca tca 2885 Ser Arg Leu Thr Pro Ser Arg Phe Met Lys Ala Leu Ser Tyr Ala Ser 460 465 470 tta gat aaa gaa gat tta ttg agt cct att aat caa aat acc ctg caa 2933 Leu Asp Lys Glu Asp Leu Leu Ser Pro Ile Asn Gln Asn Thr Leu Gln 475 480 485 cga tct tcc tca gtg cgg tcc atg gtg tcc aca tat ggg ggt 2981 Arg Ser Ser Ser Val Arg Ser Met Val Ser Ser Ala Thr Tyr Gly Gly 490 495 500 tca gat gat tac att ggt ctt gct ctc ccg gtg gat ata aat gat ata 3029 Ser Asp Asp Tyr Ile Gly Leu Ala Leu Pro Val Asp Ile Asn Asp Ile 505 510 515 ttc cag gta aag gat att ccc tat ttt cag aca aaa aac ata cca cca 3077 Phe Gln Val Lys Asp Ile Pro Tyr Phe Gln Thr Lys Asn Ile Pro Pro 520 525 530 530 535 cat gat gat cga ggt gca aga gca ttt gcc cat gat gca gga ggt ctt 3125 His Asp Asp Arg Gly Ala Arg Ala Phe Ala His Asp Ala Gly Gly Leu 540 545 550 550 cca tct gga act gga ggt ctt gta aaa aat tct ttt cac ttg cta cga 173 Pro Ser Gly Thr Gly Gly Leu Val Lys Asn Ser Phe His Leu Leu Arg 555 560 565 cag cag atg agt ctt acg gaa ata atg aat tca atc cat tca gat gcc 3221 Gln Gln Met Ser Leu Thr Glu Ile Met Asn Ser Ile H is Ser Asp Ala 570 575 580 tct ctg ttt tta gaa agt aca gaa gac act gga cta cag gaa cat aca 3269 Ser Leu Phe Leu Glu Ser Thr Glu Asp Thr Gly Leu Gln Glu His Thr 585 590 595 gat gat aac tgc ctt tat tgt gtc tgt att gaa att ctg ggt ttc cag 3317 Asp Asp Asn Cys Leu Tyr Cys Val Cys Ile Glu Ile Leu Gly Phe Gln 600 605 610 615 ccc agc aac caa ctg agt gca ata tgt agt cat tca gac ttt caa gat 365 Pro Gln Leu Ser Ala Ile Cys Ser His Ser Asp Phe Gln Asp 620 625 630 att cca tat tct gat tgg tgt gag cag act atc cat aat cct tta gaa 3413 Ile Pro Tyr Ser Asp Trp Cys Glu Gln Thr Ile His Asn Pro Leu Glu 635 640 645 gtg gtt ccc tct aag ttt tcg ggg att tct gga tgc agt gat ggg gtg 3461 Val Val Pro Ser Lys Phe Ser Gly Ile Ser Gly Cys Ser Asp Gly Val 650 655 660 tct caa gaa ggc tca gct agc agc acc aaa ag gaa ttg tta cta 3509 Ser Gln Glu Gly Ser Ala Ser Ser Thr Lys Ser Thr Glu Leu Leu Leu 665 670 675 ggt gtt aaa aca att cca gat gat aca cca atg tgc cgt ata ctc ctt 3557 Gly Val Lys Thr Ile Pro Asp A sp Thr Pro Met Cys Arg Ile Leu Leu 680 685 690 695 cgc aaa gaa gtt cta aga tta gtc att aat ttg agt agt tca gtt tca 3605 Arg Lys Glu Val Leu Arg Leu Val Ile Asn Leu Ser Ser Ser Val Ser 700 705 710 act aaa tgt cat gag act ggg ctt tta aca att aag gag aag tat cct 3653 Thr Lys Cys His Glu Thr Gly Leu Leu Thr Ile Lys Glu Lys Tyr Pro 715 720 725 caa aca ttt gat gac ata tgc ctt tac tct gag gtt tcc cat ttg ctg 3701 Gln Thr Phe Asp Asp Ile Cys Leu Tyr Ser Glu Val Ser His Leu Leu 730 735 740 tca cac tgc aca ttc aga ctt ccg tgt cgg agg ttc ata caa gaa tta 3749 Ser His Cys Thr Phe Arg Leu Pro Cys Arg Arg Phe Ile Gln Glu Leu 745 750 755 ttt caa gat gta cag ttt cta caa atg cat gaa gaa gca gag gct gtg 3797 Phe Gln Asp Val Gln Phe Leu Gln Met His Glu Glu Ala Glu Ala Val 760 765 770 770 775 ttg gca aca cca cca caa cct ata gtt gat aca tct gct gaa tcc 3845 Leu Ala Thr Pro Pro Lys Gln Pro Ile Val Asp Thr Ser Ala Glu Ser 780 785 790 tgacctcata tttatgatgg atatagatac atactatata tattcatatt tgtggatttc 3905 ctaa aagcct cagaaaatac gactgactag gcagcaaaga caggagtatc ttctgtacac 3965 tgttccgcag ttactggtac atgaacagtt ggaactgctg actttcctaa ccaaaacaac 4025 ttccttctct cctttgttga gccttttgag gggttcatga ttcattacca cagttttaag 4085 agtttcagtt accattgtat gcaagagcca agcactgaat acctacatag gttttctatt 4145 ttctttcatt ttaaaagcgt aatgacagtg gaacaataat gggatatgca gaagcaccct 4205 tcacaagtta tttctgaatg atttttaggg taaataatac agatgccttg tttgttaact 4265 aacttgtgga aagcaggaat cagtgtctct aaggctgcat cctattacca caatggggtg 4325 tgctataact gctggtatta gagagggaac tttggccctt tcacgttttt cttaatgttt 4385 gtaacactac ttcagaggtt tataacctca aagcagaaga agagcctcaa caacccggga 4445 cttataagtt attcttatgt tactagactt gcataaagat tcttgttttc caactcttca 4505 ttttgttgca atgtgttatt acaggatata tgaaccaatt aaggtttttc actacagttc 4565 ttgaataaaa tttaaaaatc attttttatt ttaattaaaa atatttccca tttatagaat 4625 gcatatattt gcaatggact tccactttca tcaactttcc atctcatcgc tttaaacagg 4685 aacttgaaca agcactgtta gtttagacct aaaggatagg aaagcattaa ataatacttt 4745 ggatctcctg aggaaaagat aagtttgctt gcaatttaca cattccatgg ggaaagaaga 4805 gccatatttc cttaaaaaaa acattaataa agcttgttat tgagaaaaat tgtagtgaaa 4865 agccttaagt accaaatttt aaagcagcag taacttaatt tttatatcag tgtttttgtt 4925 ttgcacaaac taaatgcagt ggtaggtggg tttatgagta tattaattgc ctttatccat 4985 ttgtgaagtt aagttgatga gggcaaggtt tttgtttgtt taatttgtat atgtctaaag 5045 gtatttggaa ctttttacag gaattaaaca tatatgcaaa tttgtatata aaaatagcat 5105 ggccatcatt tgaatgcttg taaatgaaag gattatcttt tttgagatct atatataaat 5165 agaaatagaa aatccagctg gactgattag gattcttttt taattcattt gtgtataaca 5225 tttttattac aattacacat cagttttgac acagtcatag caacattaat attttcccat 5285 gatgcagatc ctttttgtaa tgggcttgtt ctttgagatc tctgtaaaga accctgtgaa 5345 ctagaaaaca taactcacag agatactttt ttaaaaaatt tatttactgg aactgaaagt 5405 tccagttggg atgaagcatt tcatctcact tcataacacc tctttgactg cacttcagtg 5465 aattgttctt atgtgcactg tgtagcaact tacattataa caaagcagat aagggctgta 5525 agctgctgct tatgttgaaa agtggttctt cagattttct ctcataaaat ccagttgaag 5585 ataaataatt tttt tatact ttatcactga acccaagtgt ttatttaaat gtcaacagta 5645 cttctaagaa cgttgcctgt catcgtggtc tttggtcttg gataactaaa ctgcctttcc 5705 agagaaccaa atgtcagagt tactagacca aatagtggtt aaaacctcca aaggaagtaa 5765 tgtaatctta ttcataatgg gattaacata ttttagacat tcattttaaa cactacctca 5825 gttaatatag agtataaaaa tctgtggttt aatccctcaa aagttaacag taattttttt 5885 tttgtcttac acacacacac accccctccc ccaccatcac tatccctgta ccctcacctt 5945 ggtcatctat cctgaaataa ggcttagtta gtattggcct gaatgttttg tgtttttttt 6005 ttgttttttt tttttactgt tactttgaaa aatatgtatg tataccttat catatctgcc 6065 tatatcactt actttgggga gatactcaga gctttgtggt tatcagtata ctaaaaaaaa 6125 aaaaaagtct acgcttaaat ttatagtgct atttggtttc tccatgattt cactgacagg 6185 tctaatacat tttctttgag tacttgtttg taaaaagtag actttatggt gaaaaataca 6245 tgcagtgcca agtgattaac ttaagtgttt aaaaatatta aattatagca gaagaggtta 6305 ggaatgatat cagcagtaat agaaataatt gagaaaatca tctataaata atagatatta 6365 cagactatag aataccaaaa taatgtcaat actgtagttt ttaaagattt taggattaat 6425 cttagtccat ataaatttgt actattggta attattgaat aattgggagg aatctgggca 6485 gttgtgctgg ttgtaaacta tgaatttcta atcgtaaagt gaattgttat ttctaattga 6545 actttttttc aagaacagat ttcagcctca catactaagt aaatactgat aaataaggaa 6605 attagaaatt tagtattcat aattaaatat gctctaaaat ttcctatact tttatttcct 6665 gtttattctt aggtagattg gaagggggaa acagtctgtt ctccctaatt aaattttttc 6725 taataacgat tagtagaata tggacattct atatgacagt gacattaaaa gaggctcttt 6785 ggaagtatat acattattaa cataatgtgt acaagtcctt ttgaaatgac aactttaatg 6845 ggtttcagct cttttatcta gagcttgaga taattcaagc tgagtttttc agggcatatc 6905 acaacggcaa agtgttcagc agtgggatat caatgcttat ttacattttc ctactgctat 6965 ttatataaaa tgttattcca ttcagaggat gccttttatc cccacattaa agcacagatc 7025 attaagcaat aaaaaccaaa ttgtctgtca ttcaaattat aactgcagtt atttttgcat 7085 ggtaagagtg aggtgctaat tttgtgtgag atgaactttg taaactactt tgggaaatgt 7145 tctttggaag taaggttttt tctcctttag tcttatgctt ccacttttgt ctcagattca 7205 caatccatta aaacatgggg aaaaaagaaa aggtaaaatt gagagacttt tgttagagga 7265 gctatttgga atgaaccaac atttc agatt ttccaaaatg taagttagga agtctccatt 7325 gtctctgcat taacaaaata cactgttact atcttaatct caagagtgtc attacagtga 7385 gaatctcatt taaaagcata ccagtgaaat taatagcagt gcttatcaaa gaacactgaa 7445 atctgtgaga atctttctag gagcattctt ttcttctttt agttccaagt tccagggtat 7505 ttttcattcc tagtaggttt atatgactca cagaatgtgg acttttttcc tgtttggagt 7565 atttttgtaa tgtaagtatc ggatagctgc accacagcat gcataaattg cacattttgt 7625 tttactttct ttatagaata tttaatttca aaaatataat ttatgccaaa aaaagcatac 7685 ctttcaattt tgctacttgg ttgatttagc acaaaatgca aagtcttggg gcagagaggg 7745 ggagtgaaaa aaattttata ggtaattgtt acaaaaatac ctgtcagaaa ccctaaagct 7805 gcattgtaaa acaaatggtg taaactagtt ttgaaaagtg gtaaggaatt gtgaaaaaaa 7865 tctcagactt aatgctctct aaccacatga gtttcttctt ttttatttag taatacgctg 7925 ctacatattt ggaggttctg gtgtttgtag gtcactgaac agacattgaa atctgattta 7985 tattgtataa ctgtaacata gaaagaaaaa gtatttatat tttttctgta agaatatttc 8045 attgagttgt gtataattta aataagattt gtccccaaat ggttttgctc accttgattt 8105 tttttgttgt gattttcttg tttttgtata atgtgtatag tttatgtcaa gggcattaaa 8165 agcctcctga agcataatct tatcaaaggg atacattgtt aataaaatgt acttaaaatt 8225 cttaaac 8232 <210> 8 <211> 6583 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2559) <400> 8 gca agt cct ggg caa cct ctt tgt cca ctt ctc agg cgt tgc atc tca 48 Ala Ser Pro Gly Gln Pro Leu Cys Pro Leu Leu Arg Arg Cys Ile Ser 1 5 10 15 gtc ctg gag act gta gta aga act gtt cca ggt ctt ctg caa aca gtc 96 Val Leu Glu Thr Val Val Arg Thr Val Pro Gly Leu Leu Gln Thr Val 20 25 30 ttc cta ata gca aaa gtg aaa tat ttg tca ggt gat att gaa gca gct 144 Phe Leu Ile Ala Lys Val Lys Tyr Leu Ser Gly Asp Ile Glu Ala Ala 35 40 45 ttc aat aac ctt cag cac tgc tta gaa cac aat ccc tct tat gct gat 192 Phe Asn Asn Leu Gln His Cys Leu Glu His Asn Pro Ser Tyr Ala Asp 50 55 60 gct cat ctg ctg cta gct cag gtt tac ttg tct caa gaa aaa gtc aaa 240 Ala His Leu Leu Leu Ala Gln Val Tyr Leu Ser Gln Glu Lys Val Lys 65 70 75 80 ttg tgt tct cag tct ctt gaa ctt tgt ctg agc tat gat aag gtg 288 Leu Cys Ser Gln Ser Leu Glu Leu Cys Leu Ser Tyr Asp Phe Lys Val 85 90 95 aga gac tat cct tta tac cat ttg ata aaa gct cag tca caa aag aaa 336 Arg Asp Tyr Pro Leu Tyr His Leu Ile Lys Ala Gln Ser Gln Lys Lys 100 105 110 atg gga gaa ata gca gac gca att aaa aca ctg cat atg gca atg agt 384 Met Gly Glu Ile Ala Asp Ala Ile Lys Thr Leu His Met Ala Met Ser 115 120 125 tta cca gga atg aaa aga att gga gct tcc aca aaa tca aaa gac aga 432 Leu Pro Gly Met Lys Arg Ile Gly Ala Ser Thr Lys Ser Lys Asp Arg 130 135 140 aaa act gaa gtt gat aca agc cat cgt tta tcg atc ttt ctt gaa ttg 480 Lys Thr Glu Val Asp Thr Ser His Arg Leu Ser Ile Phe Leu Glu Leu 145 150 155 160 ata gac gtt cac cgc tta aat gga gag cag cat gag gca acc aaa gtt 528 Ile Asp Val His Arg Leu Asn Gly Glu Gln His Glu Ala Thr Lys Val 165 170 175 tta caa gat gcc atc cat gaa ttt tct gga aca tct gaa gaa gtg cgg 576 Leu Gln Asp Ala Ile His Glu Phe Ser Gly Thr Ser Glu Glu Val Arg 180 185 190 gtt acc att gct aat gca gac ctt gct cta gcc caa gga gat att gaa 624 Val Thr Ile Ala Asn Ala Asp Leu Ala Leu Ala Gln Gly Asp Ile Glu 195 200 205 cgg gct tta agc atc ctt cag aat gtt aca gcc gaa cag cct tat ttt 672 Arg Ala Leu Ser Ile Leu Gln Asn Val Thr Ala Glu Gln Pro Tyr Phe210 215 220 ata gag gcc aga gaa aaa atg gca gat att tat ctg aag cac aga aaa 720 Ile Glu Ala Arg Glu Lys Met Ala Asp Ile Tyr Leu Lys His Arg Lys 225 230 235 240 gat aaa atg tta tat atc act tgt ttt aga gaa att gct gaa aga atg 768 Asp Lys Met Leu Tyr Ile Thr Cys Phe Arg Glu Ile Ala Glu Arg Met 245 250 255 gct aac cct cgg tct ttt ctt ctc ctt ggt gat gca tac atg aat att 816 Ala Asn Pro Arg Ser Phe Leu Leu Gly Asp Ala Tyr Met Asn Ile 260 265 270 cta gag cct gaa gaa gcc ata gta gca tat gag caa gca tta aat cag 864 Leu Glu Pro Glu Glu Ala Ile Val Ala Tyr Glu Gln Ala Leu Asn Gln 275 280g 285 aac aaa gat gga aca ttg gca agc aaa atg ggc aaa gca ctt atc 912 Asn Pro Lys Asp Gly Thr Leu Ala Ser Lys Met Gly Lys Ala Leu Ile 290 295 300 aaa act cat aac tac tca atg gca atc act tac tat gaa gct gct gct g 960 Lys Thr His Asn Tyr Ser Met Ala Ile Thr Tyr Tyr Glu Ala Ala Leu 305 310 315 320 aaa act gga caa aag aat tat ctt tgc tat gac ctg gct gag ctc tta 1008 Lys Thr Gly Gln Lys Asn Tyr Leu Cys Tyr Asp Leu Ala Glu Leu Leu 325 330 335 tta aaa ttg aaa tgg tat gac aaa gca gaa aaa gtt ctt cag cat gct 1056 Leu Lys Leu Lys Trp Tyr Asp Lys Ala Glu Lys Val Leu Gln His Ala 340 345 350 ctg gct cat gaa cct gta gaa ctg tca gct ctc atg gag gat gga 1104 Leu Ala His Glu Pro Val Asn Glu Leu Ser Ala Leu Met Glu Asp Gly 355 360 365 cgt tgt caa gtt ctt cta gca aaa gtt tat agt aaa atg gaa aaa ctt 1152 Arg Cys Gln Val Leu Leu Ala Lys Val Tyr Ser Lys Met Glu Lys Leu 370 375 380 ggt gat gcg atc act gca tta caa cag gct cga gaa tta caa gct cgg 1200 Gly Asp Ala Ile Thr Ala Leu Gln Gln Ala Arg Glu Leu Gln Ala Arg 385 390 395 400 gta cta aaa cgt gtt cag atg gaa cag cca gat gca gtt cct gca cag 1248 Val Leu Lys Arg Val Gln Met Glu Gln Pro Asp Ala Val Pro Ala Gln 405 410 415 aaa cat tta gca gct gaa att tgt gca gag att gca aaa cat tct gtt 1296 Lys His Leu Ala Ala Glu Ile Cys Ala Glu Ile Ala Lys His Ser Val 420 425 430 gct cag cga gac tat gaa aaa gca att aag ttt tat aga gag gct ctg 1344 Ala Gln Arg Asp Tyr Glu Lys Ala Ile Lys Phe Tyr Arg Glu Ala Leu 435 440 445 gtt cac tgc gaa aca gat aat aag att atg ttg gaa ctg gca cga tta 1392 Val His Cys Glu Thr Asp Asn Lys Ile Met Leu Glu Leu Ala Arg Leu 450 455 t gca caa gat gac cct gat tcc tgc ctg cgg cag tgt gct cta 1440 Tyr Leu Ala Gln Asp Asp Pro Asp Ser Cys Leu Arg Gln Cys Ala Leu 465 470 475 475 480 ctg ctt cag agt gac cag gat aac gaa gct gct accg gct 1488 Leu Leu Gln Ser Asp Gln Asp Asn Glu Ala Ala Thr Met Met Met Ala 485 490 495 gat ctc atg ttc aga aaa caa gac tat ga gaa caa gca gtg ttt cat tta 1536 Asp Leu Met Phe Arg Lys Gln Asp Ayr Glu Val Phe His Leu 500 505 510 cag cag ctt tta gaa cgt aag cca gat aat tat atg aca tta tct cgt 1584 Gln Gln Leu Leu Glu Arg Lys Pro Asp Asn Tyr Met Thr Leu Ser Arg 515 520 525 ttg att gat ctc cta aga aga tgt gga aaa ctc gag gat gtc cca aga 1632 Leu Ile Asp Leu Leu Arg Arg Cys Gly Lys Leu Glu Asp Val Pro Arg 530 535 540 ttt ttc tca atg gct gag aaa cgt aac tcc aga gca aaa ttg gaa cca 1680 Phe Ser Met Ala Glu Lys Arg Asn Ser Arg Ala Lys Leu Glu Pro 545 550 555 560 gga ttt cag tat tgt aaa gga ctg tat ctt tgg tac act gga gaa cca 1728 Gly Phe Gln Tyr Cys Lys Gly Leu Tyr Leu Trp Tyr Thr Glu Pro 565 570 575 aat gat gcc ctt cga cat ttt aat aaa gct cgg aaa gat cgt gac tgg 1776 Asn Asp Ala Leu Arg His Phe Asn Lys Ala Arg Lys Asp Arg Asp Trp 580 585 585 590 ggc caa aat gcc ctt tat aat atg atag atc tgt ttg aat cca gat 1824 Gly Gln Asn Ala Leu Tyr Asn Met Ile Glu Ile Cys Leu Asn Pro Asp 595 600 605 aat gaa act gtt gga ggt gaa gta ttt gaa aac ctg gat gga gac ctg 1872 Asn Glu Glu Glu Glu G Val Phe Glu Asn Leu Asp Gly Asp Leu 610 615 620 ggt aat tca act gag aag caa gaa tct gtg caa ctg gca gta aga aca 1920 Gly Asn Ser Thr Glu Lys Gln Glu Ser Val Gln Leu Ala Val Arg Thr 625 630 630 635 640 gca gaa aaa ctt ctt aag gaa cta aaa cct cag act gtt cag ggt cac 1968 Ala Glu Lys Leu Leu Lys Glu Leu Lys Pro Gln Thr Val Gln Gly His 645 650 655 gta cag ctt cgc ata atg gaa aac tat tgc tta atg g ac c aaa cag 2016 Val Gln Leu Arg Ile Met Glu Asn Tyr Cys Leu Met Ala Thr Lys Gln 660 665 670 aaa tct aat gtt gaa caa gca tta aat acc ttc act gaa ata gca gca 2064 Lys Ser Asn Val Glu Gln Ala Leu Asn Thr Phe Thr Glu Ile Ala Ala 675 680 685 tct gag aag gag cat atc cca gcg ctc ttg gga atg gca acg gct tat 2112 Ser Glu Lys Glu His Ile Pro Ala Leu Leu Gly Met Ala Thr Ala Tyr 690 695 700 atg atc atc ttg aaag act cca cga gcc aga aac cag ctg aag cgt att 2160 Met Ile Leu Lys Gln Thr Pro Arg Ala Arg Asn Gln Leu Lys Arg Ile 705 710 715 720 gcg aaa atg aat tgg aat gct att gat gct gaa gag ttt gag aag agt 2208 Lys Met Asn Trp Asn Ala Ile Asp Ala Glu Glu Phe Glu Lys Ser 725 730 735 tgg ctg cta ctt gct gat att tac att caa tca gca aaa tat gac atg 2256 Trp Leu Leu Leu Ala Asp Ile Tyr Ile Gln Ser Ala Lys Tyr Met 740 745 750 gca gaa gac ctg tta aaa cgg tgc ctg cgt cat aat aga tct tgc tgc 2304 Ala Glu Asp Leu Leu Lys Arg Cys Leu Arg His Asn Arg Ser Cys Cys 755 760 765 aaa gct tat atg ga atat g t atg gaa aaa gag caa gca tat 2352 Lys Ala Tyr Glu Tyr Met Gly Tyr Ile Met Glu Lys Glu Gln Ala Tyr 770 775 780 aca gat gct gcc ttg aac tat gag atg gca tgg aaa tat agc aat cgg 2400 Thr Asp Ala Ala Asn Tyr Glu Met Ala Trp Lys Tyr Ser Asn Arg 785 790 795 800 aca aat ccg gca gta gga tac aaa ctg gca ttt aat tac tta aaa gca 2448 Thr Asn Pro Ala Val Gly Tyr Lys Leu Ala Phe Asn Tyr Leu Lys Ala 805 810 815 aaa aga tat gt g gat tca att gac ata tgt cac cag gtt ctt gaa gca 2496 Lys Arg Tyr Val Asp Ser Ile Asp Ile Cys His Gln Val Leu Glu Ala 820 825 830 cat cca act tat cca aaa atc aga aag gat ata ctt gat aag gcc cgt 2544 His Pro Thr Tyr Pro Lys Ile Arg Lys Asp Ile Leu Asp Lys Ala Arg 835 840 845 gcg tct tta aga cct tgaaaataat tttaacttag gtgttggttt aacaggaaatgtt 2599 Ala Ser Leu Arg Pro 850 gaaagatag tcttactgt ttg tctttg tgtacatcaa gagaagtact 2719 atgtgaaatt ggtgtttcct aatggagttg aatgagagct ggtctatttg actctgtttt 2779 gattgggtac agatttggtg actctgtggt aaagactata attatttcta taaagaatat 2839 tttgttaaaa tctaggtaat taaataccct gtatcttttc taaggaatat tatttcagga 2899 aatatattta aaatgcattg ttctctttta aagtgttttt gttatattct tttatttatt 2959 tatttatttt taaagacaga gccttgacct gtttttgttg tattctgtgt tgtttcaaaa 3019 attggaataa atctccctgt aaataactca tgaaaaagac aatatatata ttttaaatat 3079 atattttaat aaaggtttta taaatagatg atttatattc ctcttggaac tcaaaagatg 3139 tggtaagttt tgcaaatcag ggtaagctcc ccctgcattc tgtaatgtta atgggtggtg 3199 gtatagtaca gaaaatgtaa ctttcattga aaaatctttt ttagaaaagg gtagagtgtg 3259 tgtttccctt tcctttcttg agctcattct tcctgctttc aaggccattg tggtcttaag 3319 aaataatcag gtcctgaaac ctcaatttaa ataggtccct tattagggat atttaacctt 3379 agcctagaag acttggtctg cagttataat ttcagacact gtaacatttg atggtaaagg 3439 gtgaccaaat acttttggtc agcagggagt cacaaagcac accatgtgaa ggcaacggtt 3499 tacccagctc tgtttaacag caccctggca tagaagcttt cactctctta cactaaattt 3559 aacctaatct aaacttaatc cttagcatta tttttaattt ctcatctaca tctttttcaa 3619 ttttc cttaa aattgtagta aacacagtcc tcaattttat ttgcatttac aataaacagt 3679 atttataagt catttgctgc tttttattaa atgtcctgtg tttgttttga actccattct 3739 cttgtttctg atcatttctc ccatttttca aaatcccttt aatttcaatt acgttataaa 3799 attccaatta ttcttctttt cacttagcaa aacagttttt tgtggggttt tttgttgttg 3859 ttgttctttg agacagagtc tcactctgta gcccaggctg gagtgcagtg gtgcgatctt 3919 ggcccactgc aacctctacc tcctgggttc aagcaattct cctgcgtcag cttcttgagt 3979 agctgggact aaaggcacac gccaccacgc ctggctaatt tttgtatctg cagtagagat 4039 ggggtttcgc catgttggct aggctggtct cgaacttctg gcctcaagta atctggccgc 4099 cttgtcacct agcttttatt tatggcattt catagaatgt ttaataatag aatttataag 4159 tcacttcata tatgttaaaa tactttcata ttccttacat ttgatcttca caaacctaaa 4219 atgccggcat tattatccct gttttacaaa tctggaatcg tgaaacatta cctctttttc 4279 tttaattcag gtggagaaat atctttcagc ctgagtggac atttttaagg acaatgctat 4339 ggactgaatg tttgtgtacc ccaaacttcg tatgttgaca tcctagtctt taatgtgata 4399 gtattgggaa gtgaagcttt aggaaataat taggtcataa ggctgaagcc cttgcgagtg 4459 cgattagtgc ccttaaaaag aggatcccag agagttctct agctatcttt ctaccatgtg 4519 aggacaaaat aagaagtcaa ctatttgcaa cccaaaagag ggtcctcacc agaacctggt 4579 ggtgctggaa ccgtgatctc agacttccag cctccagaac tgtgagaaac agatttcttt 4639 tgttgataag cccaccagtt tatgatattt tattattgca gccggagctg actcaggcag 4699 aaatcacatt aacagaatgc ctttagtagt tccagtgaac ttgcgtcatg ggatgctgga 4759 atcatggaaa ttggatagag aaatagagca tctgttctct cagcaagaca tttccaaatc 4819 agttttccta tctgtaagag gagaggaagg ttttgttttt gtttcttaag cagccattta 4879 ttttgcacct gccatttgtt agatgctatt ttagggactt tccttacttt atgtctttta 4939 attttcagtc agctattaag agaaataata ttcccacttt tcagatgaga aagatgagac 4999 ctggactaaa tgatttgccc agggtcacag agaaaagtgt cagaacctga attccatact 5059 ggcccagtca acttcaaagc ctctgcctta tttattatat taagatgcct tctataacta 5119 agagataatg tttctgtaag aagaagtgat cttttctaca tctggctagc agaagaaact 5179 ggtgtatcac agagatagct aaataatgaa gaacaagatg gactgagtgg aatgaacagc 5239 tgttacaaat gtagaaacta ttaaagagca gtctaattga ggagcactat agtgtagcag 5299 tcaagagcat ggatc tgaaa tcagaccagc ctggatttaa gttttggctc taccattacc 5359 tagatgtttc atctttctcc aagttacaca ctctcagcct cagttttctc acccataaac 5419 aagcatataa ggataataac ctgcctcagg ttgtaaggat taaagggaac ttatataaaa 5479 cctataatga atctgactca ctaggctctt aatagtagct cctcttataa gcagaacagg 5539 gcaaagtagt aattgcaact gagaagagaa aatgcagttc aaagcaagat taaaaggatg 5599 agtaaagtcc cctagagagc tcagccctac aggatttgag attctcattc attcacacct 5659 tccctccttc cttcccttct aatttttgtt caactaattc cctcttttcc tctctctcta 5719 cccaccaacc attatgctag actccacatg cagcatctca ttttatccac ctggagcttg 5779 cttttgccct actctcctca gtggagaatt ctcttcctcc tgtccctccc ttcacccccg 5839 cttcctgtct ctgagcttcc ttctccaggt ttgctccttt ccatcaggta tcactttatc 5899 accacctcct caaagaggcc gtgttcatgt ccaggcccac aatctcaagt agccatcctg 5959 tgattctgta tcatattatc ctttttaaac tctatgcagg atttactacc tctgatgttt 6019 tttcttcttt aaggatttga ttgccttatg tgacaagccc aagatctgtg acagttggag 6079 ctcaaactag gcagtcttga ttccagactg ctctgaacta gtatttgaag gaactaatga 6139 acatgacatg ttaaatgaaa gtttggggac gtacactcag gatggaagca gggggacaca 6199 acagaaatga aagaattttc tgtagatctg ggatctggac acctgccccc cgtcatggga 6259 aggcagtaaa caagatgcta actgatggag tgaaatcccc aggagatgca gaaggcaagt 6319 gcagctaact gaggcctcag gggcaggaga tgcccatcag gatgagagct atgtctttct 6379 ccagtgatga ctctgcttct atgaggtcac cagcagtaga accatatctt gctggcatac 6439 acttgggatg gccccgcctc ctggacttcc atctgttatc aggagaacat gaccatctgg 6499 agtcagtaca gatcatcaat ccttccacat atacaagttc attttaaatt tttaaaaata 6559 taatacaact gagaagtctt catt 6583 <210> 9 <211> 6744 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1980) <400> 9 cac ccc ggt agc agc tcc gcg gca ggg aca gct tcc tcc gga cgc ttg 48 His Pro Gly Ser Ser Ser Ala Ala Gly Thr Ala Ser Ser Gly Arg Leu 1 5 10 15 gcg ggc tcc gct ctc gcc tta cga cag ccc ggt cgg atc atg ggt ttg 96 Ala Gly Ser Ala Leu Ala Leu Arg Gln Pro Gly Arg Ile Met Gly Leu 20 25 30 ccc agg ggg ccg gag ggc cag ggt ctc ccg gag gtg gaa aca aga gaa 144 Pro Arg Gly Pro Glu Gln Gly Leu Pro Glu Val Glu Thr Arg Glu 35 40 45 gat gaa gaa caa aat gtc aag ttg act gaa att ctg gag ctc ttg gtt 192 Asp Glu Glu Gln Asn Val Lys Leu Thr Glu Ile Leu Glu Leu Leu Val 50 55 60 gca gct ggg tat ttc agg gca aga att aaa ggc tta tca ccc ttt gac 240 Ala Ala Gly Tyr Phe Arg Ala Arg Ile Lys Gly Leu Ser Pro Phe Asp 65 70 75 80 aag gta gta gga gga atg act tgg tgt atc acc act tgc aac ttt gat 288 Lys Val Val Gly Gly Met Thr Trp Cys Ile Thr Thr Cys Asn Phe Asp 85 90 95 gta gat gtt gat ttg ctc ttt caa gaa aac tct acg ata ggt caa aaa 336 Val Asp Val Asp Leu Leu Phe Gln Glu Asn Ser Thr Ile Gly Gln Lys 100 105 110 ata gct ctg tca gaa aaa att gtc tcg gtc ctg cca agg atg aaa tgc 384 Ile Ala Leu Ser Glu Lys Ile Val Ser Val Leu Pro Arg Met Lys Cys 115 120 125 cca cac cag ctg gag ccc cac cag atc cag ggg atgat att cac 432 Pro His Gln Leu Glu Pro His Gln Ile Gln Gly Met Asp Phe Ile His 130 135 140 ata ttt cct gtt gtt cag tgg ctg gtg aaa cga gct ata gaa aca aaa 480 Ile Phe Pro Val Val Gln Trp Leu Val Lys Arg Ala Ile Glu Thr Lys 145 150 155 160 gaa gag atg ggt gac tat atc cgc tcc tac tct gta tcc cag ttc cag 528 Glu Glu Met Gly Asp Tyr Ile Arg Ser Tyr Ser Val Ser Gln Phe Gln 165 170 175 aag act tac agt ctc cct gag gat gat gac ttc ata aag aga aaa gaa 576 Lys Thr Tyr Ser Leu Pro Glu Asp Asp Asp Phe Ile Lys Arg Lys Glu 180 185 190 aag gcc atc aag aca gtt gtg gac ctc tca gaa gtg tac aag ccc tgt 624 Ile Lys Thr Val Val Asp Leu Ser Glu Val Tyr Lys Pro Cys 195 200 205 cgg aaa tac aaa cgc cac cag gga gca gag gag cta ctt gat gaa gaa 672 Arg Lys Tyr Lys Arg His Gln Gly Ala Glu Glu Leu Leu Asp Glu Glu 210 215 220 tct cga atc cat gct aca ctt ttg gaa tat ggc agg aga tat gga ttt 720 Ser Arg Ile His Ala Thr Leu Leu Glu Tyr Gly Arg Arg Tyr Gly Phe 225 230 235 240 agc cgc cag agc aaa atg gag aag gct gag gac aag aaa acg gca ctt 768 Ser Arg Gln Ser Lys Met Glu Lys Ala Glu Asp Lys Lys Thr Ala Leu 245 250 255 cca gca ggg ctg tca gct aca gaa aaa gct gat gcc cac gag gaa gat 816 Pro Ala Gly Leu Ser Ala Thr Glu Lys Ala Asp Ala His Glu Glu Asp 260 265 270 gag ctt cga gca gct gaa gag cag cgt att cag tcg ctg atg acc aag 864 Glu Leu Arg Ala Ala Glu Glu Gln Arg Ile Gln Ser Leu Met Thr Lys 275 280 atg acc gct atg gca aat gag gag agc cgt ctc acc gca agc tcc gtg 912 Met Thr Ala Met Ala Asn Glu Glu Ser Arg Leu Thr Ala Ser Ser Val 290 295 300 ggc cag att gtg gga ctc tgc tct gct gag atc ag cag att gt 960 Gly Gln Ile Val Gly Leu Cys Ser Ala Glu Ile Lys Gln Ile Val Ser 305 310 315 320 gag tat gca gag aag cag tct gag cta tca gct gaa gaa agt cca gaa 1008 Glu Tyr Ala Glu Lys Gln Ser Glu Leu Ser Ala G lu Glu Ser Pro Glu 325 330 335 aaa tta gga acc tcc cag cta cat cgc cgg aaa gtc att tcc ttg aac 1056 Lys Leu Gly Thr Ser Gln Leu His Arg Arg Lys Val Ile Ser Leu Asn 340 345 350 350 aaa cag att gcg caa aag acc aaa cat ctt gaa gag ctg cga gca agt 1104 Lys Gln Ile Ala Gln Lys Thr Lys His Leu Glu Glu Leu Arg Ala Ser 355 360 365 cac acc agc cta caa gcc aga tat aat gaa gcc aag aaa acg ctg aca 1152 His Thr Ser Leu Gln Ala Arg Tyr Asn Glu Ala Lys Lys Thr Leu Thr 370 375 380 gag ctg aag act tac agt gag aaa ctg gac aaa gag caa gca gcc ctc 1200 Glu Leu Lys Thr Tyr Ser Glu Lys Leu Asp Lys Glu Gln Ala Ala Leu 385 390 395 400 gag aag ata gaa tcc aaa gct gat cca agt atc cta cag aac ctg aga 1248 Glu Lys Ile Glu Ser Lys Ala Asp Pro Ser Ile Leu Gln Asn Leu Arg 405 410 415 gca ctt gta gcc atg aat gaa aat ctg aaa g caa gaa cag gaa ttt 1296 Ala Leu Val Ala Met Asn Glu Asn Leu Lys Ser Gln Glu Gln Glu Phe 420 425 430 aaa gca cat tgt cga gag gag atg aca cga cta cag caa gaa att gaa 1344 Lys Ala His Cys Arg Glu Gl u Met Thr Arg Leu Gln Gln Glu Ile Glu 435 440 445 aac ctg aaa gct gag aga gca cca cgt gga gat gaa aag acc ctc tcc 1392 Asn Leu Lys Ala Glu Arg Ala Pro Arg Gly Asp Glu Lys Thr Leu Ser 450 455 460 460 agt gga gag ccg cct ggt acc ttg acc tct gca atg act cat gac gaa 1440 Ser Gly Glu Pro Pro Gly Thr Leu Thr Ser Ala Met Thr His Asp Glu 465 470 475 480 gac cta gac aga cgg tat aat atg gag aaa gag aaa ctt tac aag ata 1488 Asp Leu Asp Arg Arg Tyr Asn Met Glu Lys Glu Lys Leu Tyr Lys Ile 485 490 495 cgt tta cta cag gct cga aga aat cga gaa ata gca att ttg cac cgc 1536 Arg Leu Leu Gln Ala Arg Glug Asn Ala Ile Leu His Arg 500 505 510 aag att gat gaa gtc cct agc cgt gcc gag cta ata cag tat cag aag 1584 Lys Ile Asp Glu Val Pro Ser Arg Ala Glu Leu Ile Gln Tyr Gln Lys 515 520 525 aga ga ttt att gaact cgc cag att tca gca gtg cac aaa gaa acc 1632 Arg Phe Ile Glu Leu Tyr Arg Gln Ile Ser Ala Val His Lys Glu Thr 530 535 540 aag cag ttc ttc act tta tat aat acc ctg gat gat aaa aag gtt tat 1680 Lys Gln Phe Phe Thr Leu Tyr Asn Thr Leu Asp Asp Lys Lys Val Tyr 545 550 555 560 ttg gaa aaa gag att agt ctg ctg aac tca att cat gag aac ttc tca 1728 Leu Glu Lys Glu Ile Ser Leu Leu Asn Ser Ile His Glu Asn Phe Ser 565 570 575 cag gcc atg gcc tcc cct gct gcc cgg gac cag ttt tta cgt cag atg 1776 Gln Ala Met Ala Ser Pro Ala Ala Arg Asp Gln Phe Leu Arg Gln Met 580 585 590 590 gaa cag att gtg gaa gga att aa ca aga atg aag atg gaa aag 1824 Glu Gln Ile Val Glu Gly Ile Lys Gln Ser Arg Met Lys Met Glu Lys 595 600 605 aaa aag caa gag aac aaa atg aga aga gac cag ttg aac gac cag tac 1872 Lys Lys Gln Glu Asn Lys M Arg Arg Asp Gln Leu Asn Asp Gln Tyr 610 615 620 ttg gag ctg tta gaa aag cag agg cta tac ttt aag act gtg aaa gag 1920 Leu Glu Leu Leu Glu Lys Gln Arg Leu Tyr Phe Lys Thr Val Lys Glu 640 630 635 aag gag gag ggc cgc aag aac gag atg ctg ctg tcc aag gtg aaa 1968 Phe Lys Glu Glu Gly Arg Lys Asn Glu Met Leu Leu Ser Lys Val Lys 645 650 655 gcg aag gcc tcc tgaacgtccc cagccgtgg tgtat tttact 2020 Ala Lys Ala Ser 660 tttaagcacc gtatatcacc tacaagatca tgaaatggtt ctgaaagcga cagtagagag 2080 atgcagttgt gatgatttca acaacctgga tgttttcttt ctcctctttg cttccattca 2140 tctctgttgg ctgctgttga tggagtcaga cagtaaacac gtggcttgga taacacccat 2200 catcctatga agaatatagg gagtacttgt tctctgttga ttcaactttt atgtctccag 2260 taacattgcg cttatgaagg tacctgtatt tgtatggact ctgaataaag aagaattcat 2320 ttgtttagca agtattagtt cagcaaccac tgagaaataa gcactgagga agattcagag 2380 acgtgtaaaa cacagttcct actgcacaag tacccagcag gtggcccagg gaggcagata 2440 cagcacactt gaccgcagaa ctgggctatc caagatgttt ttcagtaaac agaaggcatt 2500 tagctgaaat gatcagccca tgtagtgttg gtcacttggg cctttcacct gccatggtac 2560 cttttgttcc cagctcctcc aggtgccagc cagcaggctt ggtggtgaca gcaactggaa 2620 cgaaagttca gtgttgtttt aatttttata cgttactcaa gttgatttct cagaaaattg 2680 aaaacagacc ttgtgctgag gacacgtcaa taaaaattat accttcccct gccccaatgt 2740 tcatgtgagt cacagcatgc agaggggctg tgcatccccc tcattgaagg cacatttgat 2800 gaggctacgc tgcagatggg tcatggtctg agccaggaga g agatagaca ctgttccctg 2860 cactcaaggc aagtagggtg tcaggaggaa gagcagtagg gtttgcagag atccagggaa 2920 acttcctgga ggaggcagca tttgagccct atctaaaggg agaatcggat gttgatagga 2980 agactgtttt aaatgaaaat acactatgat taaaaaccca agagagtgca gaggagtaca 3040 aggcatgcat gttgggaaag gaggggataa gctagtctct gcaggaggct tcagagaccc 3100 gtctgggaag tagggctgag actaggcttt ggagggcctt gaagggcagc tgagggttga 3160 ttttaatcct tggaaatgac cagtgcagat caaacatgga gctcctgctg ccctggtcct 3220 caggagtctg gtaactcagt catgttctgt aggtttgtgc tccattttgc ataaatcttg 3280 caaacatacc aggtggcagg tttgcacagt aacacaaaag cttaaacatg tcaagcaagt 3340 ggggcattca gcagccacag aaatgtgttc atttttagtc cctaatggat gtgattaagc 3400 agggctgatg tgtacagatt taaaaacaca cacacgtgct ggattaaaaa cagccactgg 3460 tttcagtgcc agggccagca aggcctacct gagccaggcg gaagcagcag cttgcaaata 3520 gaaactgcca cctgcgagcg cttcttgggt catgtgcagc tccacctcag ctggtccctg 3580 agccgtggtc atgtgggggt tttgaagggc taagttgaag caagtaattg caaaagaaca 3640 ggtggcactc tgagggcagg ggaaggagac agaagtttga ctgcgtt tga aattatttca 3700 gtcagggaaa catctgcgtt gtcttgttaa gcagcttgta ggcccacccc tggctaactg 3760 aactttgtga gcagttgggg cagttatttg gatatttgtc caaaggtggt agggaggcag 3820 atgacattct ggggttactg gagtccacct ctgtgctgat ggggaaagta tggcatgatg 3880 aatccaaagc aaccagtaat tctttttgaa agtgcaggca tttattttga gctgtatttc 3940 ataggagttt catttggttt ggttttggta tagagaggtg tccatagatc tctattccct 4000 tttttttttt atcgacaagg cctactacgg ataaatcagt ttttgttgcc tgaatacact 4060 ttgaattaga ctacagaagc cagtttgagc tcaaatttca cacttgctgc agacaactct 4120 cagtgtggac agtgcctttc tgagtaatta ggatgttata tgactttttg gtgaagccgt 4180 atagggtaag gagatgcccc aaggcccctg atcatttcag aagccacctg gagcaccaga 4240 aggggtcatc ttcccagggc tatggctctg tgtgcttaga catagtatgg aattgtgctc 4300 taagcccaca ggcttctcca gagttaaaag gaagcaagaa catccttaag ttactttttc 4360 aaaatatgcg cttcaggagg aaccaggttt ccccaggaga gagaggctcc ctgctcaatc 4420 agcacaggga gttgctagcg ggcaggctgc ccagtgctgt ggaatctccg ccagcctctg 4480 ggttgggggc tccctcccac ttcttgcttc ttatggagta catgggactg c tctgcttta 4540 agccgcgatc agagctgttg tgagcaggac aagattgcgt gatcacgagg tgcgtgggga 4600 gatgctagga catttgttga tgtctttgac ctgtgctccg tctctgttgg atgactgggt 4660 tagctaacac cactagaggg aggtacagaa tgttaaacag tcgtcagagt cacactgagg 4720 gttgttttaa cagagggcaa attcccagtt tgtcaagcat atctctgtta gagtccgaag 4780 ttcatggttt taatggttct agctcgtagc ccttaatatt ttcaggatag ctgggtcctg 4840 ccagtgtccg ctgagtccat cagcacaacc agaaggtcca gggtccaggc atgggaagca 4900 ttctctgaca ataccgagcc ctcgggacct cctgaaacct tgagcagagg ctggagaaga 4960 ccttcagaca gtccttttac tacctcacaa agtgccatgc ccgggacctc agacctcagg 5020 gttgtgacgt tgttgatgtt gtcaggcccc agtacgtctc tagtgaccga agcagacctg 5080 cctgaaaggg cactccggac agtgagccct ggctctaacc tgtgccctca tatttctgct 5140 gcctcatatg gtcttgtttg cccactctgt aggtgactga tgatcaccct aaaagggagg 5200 taggtatcta gcagtagcac agttactttg agcctgacca cttgttctga agtgcagatg 5260 ttgaaacatg cattgaggaa gaacacttta aggaagcact ttatgattta ctcatggctg 5320 gtgttggcct caaagtaaaa gaacatctta atgcagaaca gtacaataaa gagcccc ata 5380 ggatggatgc catcatctgt ccccatggtt gggattgcca aggaaagtgc cttgttctgt 5440 gcatcttcag aatcccccag gccctctctt gatccttttc atgaagtcca gagcattcct 5500 tctattacag gctgaagatg cattgtaaaa ggtaatgcta taatagtatt ccctcttctc 5560 aataaatgtg caaaactgga gaatctggtg ctgatctgca gcatacttga caacacaggg 5620 aataccgtgg atgttccacg ccagccttac atccgtcccc attgcctgcc catgtccagt 5680 ggccctgcgc aacaaaagta agggcttgtc ttaccacact ctccccagca tctagctcaa 5740 ggtagatgac tgactgggaa attccggttg gataaaatgg cttttccaca ttgcaacttt 5800 gcatctctat taggaaaatt tagattgaac ctttcctcta cttgatgctt agtttgagaa 5860 cagttttcac aactttagag ggtctctctc agagtatgtt atactgtaac cttgaagttt 5920 gagatgaaac aaggtgtcag aggttttgaa tctttcaaag gaattgcctt ttacagattt 5980 tttttttatt ccctaagaag ggaaaaagag agggaagaac tacactaatg ttagagataa 6040 ggtatgtttt ggctcaaaat gtgtcatgaa cctaaaggta acttgatggg cagaaatgtc 6100 tcagccatgt gaaccaagaa gtgggaccac agtgcaaggc tgtgggtggc agcactagat 6160 atggtggtgg caggagtgtg acatgtaggc actccatggg ggacagctgg acggtgtcta 62 20 tcaaaagtgc aaatgcgtaa gctctttgaa ctagcaatgc tactcctaag aattgtacct 6280 gtgtacaagg tacttgtgta caagagtttt tgttgaaaca ttgtaatagc aaaaagttgg 6340 agagtgccac caatacaggg gaatggttaa atacattatg gccagcttaa acaatggaat 6400 agtttgtaga aatttaaaac aatggatcct gtgtgtgtgt actaccatag aatgggcccc 6460 aagatgcatg attaagtgag gaaaaaagcc catggtatcc taatgtttgg aatggagaaa 6520 gtgtgtagat gtatgtgtgt gcatatgttt tcacacagac gtatacacgt gtatatcata 6580 tgtccacctg catatgccta ggatgtctct gggaggatat ctagcagccc ggcagcctga 6640 attgcctctg ggaagagggg tgggaatgac ttttcaatgt acaccttttg taccttttga 6700 attttgtacc atgtacatgt attatctatt aaaaaatagt tctt 6744 <210> 10 <211> 6545 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1597) <400> 10 c ggg gac tgg cct ggc gcc ggc ggc ggc gga ggg ggc gcc gcg ggc ggg 49 Gly Asp Trp Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Ala Ala Gly Gly 1 5 10 15 cga tgt gag cgc ggc gct ctg aga gta cgc ttc atg tca gta gaa 97 Arg Cys Glu Arg Gly Ala Leu Asp Arg Val Arg Phe Met Ser Val Glu 20 25 30 atg gac agc agc agt ttt att cag ttt gat gtg ccc gag tac agc agc 145 Met Asp Ser Ser Phe Ile Gln Phe Asp Val Pro Glu Tyr Ser Ser 35 40 45 acc gtt ctg agc cag cta aac gaa ctc cgc ctg cag ggg aaa cta tgt 193 Thr Val Leu Ser Gln Leu Asn Glu Leu Arg Leu Gln Gly Lys Leu Cys 50 55 60 gac atc att gta cac att cag ggt cag cca ttc cga gcc cac aaa gca 241 Asp Ile Ile Val His Ile Gln Gly Gln Pro Phe Arg Ala His Lys Ala 65 70 75 80 gtc ctt gct gcc agc tcc cca tat ttc cgg gac cat tca gcg tta agt 289 Val Leu Ala Ala Ser Ser Pro Tyr Phe Arg Asp His Ser Ala Leu Ser 85 90 95 acc atg agt ggc ttg tca ata tca gtg att aaa aat ccc aat gtg ttt 337 Thr Met Ser Gly Leu Ser Ile Ser Val Ile Lys Asn Pro Asn Val Phe 100 105 1 10 gag cag ttg ctt tct ttt tgt tac act gga aga atg tcc ttg cag ctg 385 Glu Gln Leu Leu Ser Phe Cys Tyr Thr Gly Arg Met Ser Leu Gln Leu 115 120 125 aag gat gtt gtc agt ttt ctg act gca gcc agc ttt ctt cag atg cag 433 Lys Asp Val Val Ser Phe Leu Thr Ala Ala Ser Phe Leu Gln Met Gln 130 135 140 tgt gtc att gac aag tgc acg cag atc cta gag agc atc cat tcc aaa 481 Cys Val Ile Asp Lys Cys Thr Gln Ile Leu Glu Ser Ile His Ser Lys 145 150 155 160 atc agc gtt gga gat gtt gac tct gtt acc gtc ggt gct gaa gag aat 529 Ile Ser Val Gly Asp Val Asp Ser Val Thr Val Val Gly Ala Glu Glu Asn 165 170 175 ccc gag agt cga aac gga gtg aaa gac agc agc ttc ttt gcc aac cca 577 Pro Glu Ser Arg Asn Gly Val Lys Asp Ser Ser Phe Phe Ala Asn Pro 180 185 190 gtg gag atc tct cct cca tat tgc tct cag gga cgg cag ccc acc gca 625 Val Glu Ile Ser Pro Pro Tyr Cys Ser Gln Gly Arg Gln Pro Thr Ala 195 200 205 agc agt gac ctc cgg atg gag acg acc ccc agc aaa gct ttg cgc agc 673 Ser Ser Asp Leu Arg Met Glu Thr Thr Pro Ser Lys Ala Leu Arg S er 210 215 220 cgc tta cag gag gag ggg cac tca gac cgc ggg agc agt ggg agc gtt 721 Arg Leu Gln Glu Glu Gly His Ser Asp Arg Gly Ser Ser Gly Ser Val 225 230 235 240 tct gaa tat gag att cag ata gag gga gac cat gag caa gga gac cta 769 Ser Glu Tyr Glu Ile Gln Ile Glu Gly Asp His Glu Gln Gly Asp Leu 245 250 255 ttg gtg agg gag agc cag atc acc gag gtg aaa gtg aag atg gag aag 817 Leu Val Arg Glu Ser Gln Ile Thr Glu Val Lys Val Lys Met Glu Lys 260 265 270 tcc gac cgg ccc agc tgt tcc gac agc tcc tcc ctg ggt gac gat ggg 865 Ser Asp Arg Pro Ser Cys Ser Asp Ser Ser Ser Leu Gly Asp Asp Gly 275 280 285 tac cac acc gag atg gtt gat ggg gaa caa gtt gtg gca gtg aat gtg 913 Tyr His Thr Glu Met Val Asp Gly Glu Gln Val Val Ala Val Asn Val 290 295 300 ggc tcc tat ggt tct gtg ctc cag cac gca tac tcc tcc ca gca 961 Gly Ser Tyr Gly Ser Val Leu Gln His Ala Tyr Ser Tyr Ser Gln Ala 305 310 315 320 gcc tca cag cca acc aat gta tca gaa gct ttt gga agt ttg agt aat 1009 Ala Ser Gln Pro Thr Asn Val Ser Glu Ala PheGly Ser Leu Ser Asn 325 330 335 tcc agc cca tcc agg tcc atg ctg agc tgt ttc cga gga ggg cgt gcc 1057 Ser Ser Pro Ser Arg Ser Met Leu Ser Cys Phe Arg Gly Gly Arg Ala 340 345 350 cgc cag aag cgg gct ttg tct gtc cac ctg cac agt gac ctg cag ggc 1105 Arg Gln Lys Arg Ala Leu Ser Val His Leu His Ser Asp Leu Gln Gly 355 360 365 ctg gtg cag ggc tct gac agt gaa gcc atg atg aac aac ccc ggg Gt tat 1153u Gly Ser Asp Ser Glu Ala Met Met Asn Asn Pro Gly Tyr 370 375 380 gag agc agt ccc cgg gag agg agt gcg aga ggg cat tgg tac ccg tac 1201 Glu Ser Ser Pro Arg Glu Arg Ser Ala Arg Gly His Trp Tyr Pro Tyr 385 390 395 400 aat gag agg ttg atc tgt att tac tgt gga aag tcc ttc aac cag aaa 1249 Asn Glu Arg Leu Ile Cys Ile Tyr Cys Gly Lys Ser Phe Asn Gln Lys 405 410 415 gga agc ctt gat agg cac atg cg cct cat gga atc acc ccc ttt 1297 Gly Ser Leu Asp Arg His Met Arg Leu His Met Gly Ile Thr Pro Phe 420 425 430 gtg tgc aag ttc tgt ggg aag aag tac aca cgg aag gac caa ctg gag 1345 Val Cys Lys Phe Cys Gly L ys Lys Tyr Thr Arg Lys Asp Gln Leu Glu 435 440 445 tac cac atc cgg ggc cat aca gat gat aaa cca ttc cgc tgt gag atc 1393 Tyr His Ile Arg Gly His Thr Asp Asp Lys Pro Phe Arg Cys Glu Ile 450 455 460 460 tgc ggg aag tgc ttt cca ttc caa ggt acc ctc aac cag cac ttg cgg 1441 Cys Gly Lys Cys Phe Pro Phe Gln Gly Thr Leu Asn Gln His Leu Arg 465 470 470 475 480 aaa aac cac cca ggc gtt gct gag ggt gag cgt tcc ccc 1489 Lys Asn His Pro Gly Val Ala Glu Val Arg Ser Arg Ile Glu Ser Pro 485 490 495 gag aga aca gat gtg tac gtg gaa cag aaa cta gaa aat gac gca tcg 1537 Glu Arg Thr Asp Val Tyr Val Glu Gln Lys Leu Glu Asn Asp Ala Ser 500 505 510 gcc tca gag atg ggc cta gat tcc cgg atg gaa att cac aca gtg tct 1585 Ala Ser Glu Met Gly Leu Asp Ser Arg Met Glu Ile His Thr Val Ser 515 520 525 gat gct ccc gat taagatggta cccaaacaaa gcacattaat 1637 Asp Ala Pro Asp 530 caatgcatat ttgtgatttg ctttgttgta atctttggtt ttcccaacca tctggaaatc 1697 tcttggtctc ttggcagttt ttctaaagtt tctggatgga acacttcgtt gtgtttat cc 1757 tttcccctgc cctccctccc cgaaggagct caaagcatga agggcaacgc atccagggaa 1817 aacacaggct gacagtattc ctctttggct gaactcttaa tccaaaatct gccagtgatt 1877 tagctatgcc aactggttga ccctccattc tctgccaaga ggcatactct ttctcattgt 1937 gtgcgctggc agcagtgcac ttccacggag ggagattagg atgccgtcag ctgatacaaa 1997 tgggtaacct tttctaattt aaaattcctt ttagggggta gttagacaat ttatatatat 2057 atataataaa actattatta tatatatagt atatatacat tttcaaattt gattttattc 2117 tggttgaggt gaatgtaaga ggaatatata atttaataca atgtgaacag ggcttctgag 2177 tctatctcat ccctacctaa tatgttaggg ttttgcccct tcatttccct tacaaaagaa 2237 tgttagtagg tttatattaa tcattgtgtc caaaagcaag caaagcaaat cacagtgttc 2297 acagctctgc ttcataacaa atacataaac caaatgccat aaaatttctt caactctagt 2357 tggaaaccgt ttggaatttt tgttagttgt ccagcaggta agctggatga cctgtggtgc 2417 tgaccttttt acatagtgta gtgttatatt agccaacccc aaaggagcag tggttttcaa 2477 ggtttttact ggcctacaaa tctaccttca ttccgtactg tagaaacata cataccaggt 2537 aactaaatcg aatcactctc tatcatgagt tagtactcac tcgcacttaa ggaaagggat 259 7 ttgtagttct gtctacaaaa ttctccaagc agtgttgtgg ttttttttgt ttttgttttt 2657 tttctttctc ttttcaaaca gccagttcag gtgcacagca actttttcta catgcagttc 2717 ccagggaaac tgcagaactt agaatttgta ctttttgtaa agctatactc tatgggaatt 2777 gcaagcaata tatctatctt agtattgtgt gtgctaatga gagcctcagt ggctccccca 2837 ctctctcagt gtttcctgct taaagaacca acagtttaaa agccctctaa gatactctgt 2897 gtgtcaccaa atctgtgtgt caccattttt tggtcatgtg gtgctatttt tgttaagtgt 2957 ctttttaggt cagtatagtt gtagaaaatg tgaaatctga tggtaataat gaattataat 3017 tgttttcctc tcttgagttc atagcttgaa aagagacctc aaaagcatgt gctggcaaac 3077 acgttactgt atgaaaacat acctgagtcc atttgaataa tgttttatta gtactttcgg 3137 aaatgtcttc agttctgtat tgtgttcaca tacacaaaca ggctttacaa gattgcttcg 3197 gtactgtaaa ctctggcaga gagtaatttt gtaggcagtt tggtggtgag tttgtgctgc 3257 aggctgcctg tgggatgtca gcgttctggt atctgcctga gaacctgggc tctgagacgc 3317 acaaccagtg cacctccata ggagaacagt gcagccacct aaaagaaaaa cgaacgaagg 3377 accagcctca gaggctagaa gttaaaggaa tacagaatta gatgtttgct ggttttctgt 3437 gctt ttttgg ctcctaaaat accaatggtg gatttgtttt tgtttttgtt ttttgttttg 3497 agaaataaaa agtcattcaa gccctttgtg tgtaatagcc cccaggggtg gcagctgtgc 3557 agtcgcatct ctttggcaca caggatctgt tcacgtgtga actgctgcgc tacacatcag 3617 tgttaactcc ctacagatta cactctaatc ccgctgctcc cgaggagcgg ctttgctaaa 3677 tcgggtatat agtatatgcc tttttcctcg tcaaactgcc taagtagggg ttcgttctct 3737 ccctgaagca cttgttcaac tcctgttaaa gccgcgtgcc tcaaggggag gctggacccc 3797 aagtgtttac ccacttaaat atgttctggg gtttcaggta aatgtttgtg ggtttttttt 3857 tccttacatg aataagtttg gttttgattt ttttttaatt gaatgcaaaa aatttgtgtt 3917 gtgatacaaa ttaagtttgt gacaagaaat gcccaaatcc aaggacataa gaggtcaagc 3977 tcagggaagg aacctccttt tcactcaggc ttggggcctc cagcgaggtt tccagagcat 4037 tccatggtat gagagacagt gaggagggag ggcacctggc gcgggcactt ccagcgtcct 4097 ggctcttggc attgtccgtc ttaaccttat ttacatggag ttctttgtat ttgtgaatct 4157 gtttaactgg tttgagttta ccaaagagtg acttatccaa aattgtcttt gacaaaaata 4217 tccattgctt tgattgtaca gttcaggttc aaacattgta atgggactgt taaggggcag 4277 aaaattgat t gagtttctct ctaagaatca tgattccaca ttttgcaagt tccacttgct 4337 cccattcgtg ttgctaacac tttacccttt ccactgctcg cagtgttaag aatgaattct 4397 caagccataa cacagtactg taaagttccg cagggcttcg agggaggcag cgcctaggcc 4457 agcacggagc tgtgtagcct ctctgagcgt tcgcactgtc atgcttccca ggggtgtgac 4517 tggtgagaga ttaactccat tcagatcggg cagcagcaat taattgtgcc ttgccgcatg 4577 aggatgtgtc aggaggatta acatgaccac agaaccgaaa cattctctcc ctgaagttca 4637 cttcacgtct ccgcagacga agtacgctgt gtaactcctt agagcaactc tttttggaaa 4697 gcaaagtccc tatttctgta cagttttagg ttaggtgttt catttataac agatgcagaa 4757 atcaattaag ataaagtgat atgtgaagaa atcttttaca gtaaaatata tcctgaattc 4817 atataggctt gttcataatt gagtctcttc ttgagctacc ttttcaatat tagacaatgt 4877 gaagacagtg acagcgtcct tttctagaga tatttagcct gttattacaa actgtgaaga 4937 caaagaattt tatactttta ctaatgtttg tggttttaaa cagttatttt cattctaatc 4997 agttctctac cctctaattt ctactaaagc tgtaaataca tttagaaatt atatttgtaa 5057 atacagtata tggagacaag ttaatttttt ggtcagtgga aaaagcctcc caaccaattg 5117 gccctgcctt ggca gttgtg ttttttgttg ttgttgttgt tgttttagtt tagttttttt 5177 tttttaaaca gcagaaagga tactgtcggt tcactgttga gcagaatata ctgtagaacg 5237 aaaatgataa tttttaaatc ttccagagca tgagtaaatg tcttttctaa tgatagcaaa 5297 tataaccaac tctttgtttt tcccttagcc cagaccatat agacctgcgt attttgtgtg 5357 tggttttgtt tttatttttg ttcttacagc ctagacccta ggaaaaattt gcaggaacac 5417 gaaacaaggg ctggggggaa aatcatctat gtgaatgagc tttactttaa agagatcaat 5477 gtattttatt ttatcaactt tttctcttag ttactgtgat ttttgttgtt gttgtcctcg 5537 ttattgttaa attctgtaat ggtttcctgt gaagcctcca ctgaaaggga ctcaaatatg 5597 caacacctaa actattttcc aagggcacat gccccttgaa tggtgcttct agactggtca 5657 gggttattta ttaaatttta tatatgaaag tattggggaa ttatgtaaat tctttatatg 5717 aaactatcta gttcataaat catagatttc atattactca gtgcaactga actaaaagtt 5777 cagaaaagtc attcacattg ttccaaattt gtaatggttg tcacatgtca catgcgtctt 5837 tttcagtaag tgccagagtg ttcccactgt ttctgcccag tgcttgactt ctcggcccgg 5897 aagagaacct gctttctctg gtttccttcc tgagtctggc acagacgggg ctattgtagt 5957 tcttgatcaa gtcctggagt cagccttgcc tggctctcct tgtagcagat tcagtccaca 6017 gacctcttgc tgcccctcag tgacaagtat gctgtgaatt caacctttgg acttgctgcc 6077 caagcctttg gttgctgccc tgactattgt aagaggtaaa cttacctggt ttgtttgaga 6137 atgaccattt tcctaatgtg aaaaccatct ctctcaccac ttttattagt agggctaaca 6197 tttttttccg ttataaatgg ttgagcaatt tgaatgactt aacacagtgt cattatcttg 6257 caatataaac tggtaacctc acaactccac acttcatcac catatgaagt aaatgaagct 6317 agctaagcgg atgctgtatc aactagtaac ttgccattaa ggattatttt atagcatgaa 6377 tttaagacta tttattcaaa tgatatttta ctcttgtatt cactttgttt tagatttgtg 6437 acatgaatat ttcagtgctg cttaattttg ttctgaattc ttgtttcttg cttgtaaatg 6497 gcttttttat ggtataaata aagtcaatgg acattgctgt ttgtaaat 6545 <210> 11 <211> 6714 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (241) .. (3777) <400> 11 cctgtagaag aaaaaagaaa ttctgaaaaa gaagtatcaa gtcacttcag tcatttcaag 60 atttcttcac agactcatga atctgataaa acagaagtcc aggggattca atctccagat 120 gttccagagc agttttcaga tattaattta agcaaatctc ttcctcaaga acagaagcca 180 cttgaaatta aaccagcacc ttttgtgagg agccgattca aaagaccaaa accaaactaa 240 gca aga gca gct ttg aag aga gag act aca gaa tca gaa aaa tat ata 288 Ala Arg Ala Ala Leu Lys Arg Glu Thr Thr Glu Ser Glu Lys Tyr Ile 1 5 10 15 tat gag aag aaa tca gaa acc aag aaa atg gag act att gtg atg caa 336 Tyr Glu Lys Lys Ser Glu Thr Lys Lys Met Glu Thr Ile Val Met Gln 20 25 30 gaa aat aat gaa caa act gat act ctc cct tct caa cat gat gaa gct 384 Glu Asn Asn Glu Gln Thr Asp Thr Leu Pro Ser Gln His Asp Glu Ala 35 40 45 tcc cta atg ata tca aga gaa aaa gac aca tta ggt cac agg aat gag 432 Ser Leu Met Ile Ser Arg Glu Lys Asp Thr Leu Gly His Arg Asn Glu 50 55 60 gag gct gtg ata ttg cca tgt aca cag act gaa agg aac ctt tca cct 480 Glu Ala Val Ile Leu Pro Cys Thr Gln Thr Glu Arg Asn Leu Ser Pro 65 70 75 80 tca aat tct tgt gaa cct aaa gag gag tct cag tca gca cca gtc cag 528 Ser Asn Ser Cys Glu Pro Lys Glu Glu Ser Gln Ser Ala Pro Val Gln 85 90 95 aaa aat gac tca gtt gtt tct gtg ggg act aat aat gta aac act ttc 576 Lys Asn Asp Ser Val Val Ser Val Gly Thr Asn Asn Val Asn Thr Phe 100 105 110 cag caa gaa atg aag gaa agt gtt atc caa act gct cga caa gta agg 624 Gln Gln Glu Met Lys Glu Ser Val Ile Gln Thr Ala Arg Gln Val Arg 115 120 125 ggc cga ctt cag aga ccg aga cca aat ata aga aag aca gga cag agg 672 Gly Arg Leu Gln Arg Pro Arg Pro Asn Ile Arg Lys Thr Gly Gln Arg 130 135 140 caa ata gta gac aaa ggt gaa gcc aaa ggc ata att aag gaa gga aga 720 Gln Ile Val Asp Lys Gly Glu Ala Lys Gly Ile Ile Lys Glu Gly Arg 145 150 155 160 acg ata tta cca aaa gat gaa act gaa aag aaa gtc tta act gtg tca 768 Thr Ile Pro Lys Asp Glu Thr Glu Lys Lys Val Leu Thr Val Ser 165 170 175 aat tct caa att gaa act gaa att gaa gtt cca tcg tcc gca gtt cca 816 Asn Ser Gln Ile Glu Thr Glu Ile Glu Val Pro Ser Ser Ala Val Pro 180 18 5 190 gaa cac aga atg tat gaa aat caa agt cag gtg gtt ctt gta gaa aac 864 Glu His Arg Met Tyr Glu Asn Gln Ser Gln Val Val Leu Val Glu Asn 195 200 205 ctt cat gtt aac aaa aca aat gaa aca atc aga cat gaa aat aaa ccg 912 Leu His Val Asn Lys Thr Asn Glu Thr Ile Arg His Glu Asn Lys Pro 210 215 220 tat gtt cct agt tca gca caa atg aca aga agg aaa ttc caa aag gct 960 Tyr Val Pro Ser Ser Ala Gln Met Thr Arg Arg Lys Phe Gln Lys Ala 225 230 235 240 aag cca aat ttg gga aga gca cac agt aag aaa gag gaa cca gtt tta 1008 Lys Pro Asn Leu Gly Arg Ala His Ser Lys Lys Glu Glu Pro Val Leu 245 250 255 gaa aaa gtc aca aca gat cag agc aag gaa ggc aag cca gaa gat cat 1056 Glu Lys Val Thr Thr Asp Gln Ser Lys Glu Gly Lys Pro Glu Asp His 260 265 270 ttg ctg cag aaa gga gct tcc aac acc cag ctc ctt cta 1 aaa gaaaaa Leu Leu Gln Lys Gly Ala Ser Asn Thr Gln Leu Leu Leu Lys Glu Lys 275 280 285 gct gag ctt ctg aca tct ctg gag gtt tca gca aga aaa gat tgt gta 1152 Ala Glu Leu Leu Thr Ser Leu Glu Val Ser Ala Arg Lys As p Cys Val 290 295 300 ggt tcc aaa gag tct gct ttg gca aaa ata gat gcg gaa tta gaa gaa 1200 Gly Ser Lys Glu Ser Ala Leu Ala Lys Ile Asp Ala Glu Leu Glu Glu 305 310 315 320 gtt gga cca tca aga agg gtt gga gag gaa act gta gga gat aat tca 1248 Val Gly Pro Ser Arg Arg Val Gly Glu Glu Thr Val Gly Asp Asn Ser 325 330 335 cca tct tca gtt gtt gaa gag caa tat ctc aat aaa cta aca agc tgt 1296 Pro Ser Ser Val Val Glu Glu Gln Tyr Leu Asn Lys Leu Thr Ser Cys 340 345 350 cca caa ccg tta aac gaa aca agt tac tct aaa att gcc ctg gat ggg 1344 Pro Gln Pro Leu Asn Glu Thr Ser Tyr Ser Lys Ile Ala Leu Asp Gly 355 360 365 aaa aca act atc tct tct aca tct gag tat gag aga aat cgt ggt gaa 1392 Lys Thr Thr Ile Ser Ser Thr Ser Glu Tyr Glu Arg Asn Arg Gly Glu 370 375 380 agg aga agt cat aaa aag ttc aaa cca aat gtc acc aga ggt cgt gga 1440 Arg Arg Ser His Lys Lys Phe Lys Pro Asn Val Thr Arg Gly Arg Gly 385 390 395 400 tca aaa cga gtt cgg ggt aag acc tct aag aag gaa cct aga gct tcc 1488 Ser Lys Arg Val Arg Gly Lys Thr Ser Lys Lys Glu Pro Arg Ala Ser 405 410 415 aag gcc atg ctg gtg act ctt cgg gct tcc cag gaa gaa gat gat gat 1536 Lys Ala Met Leu Val Thr Leu Arg Ala Ser Gln Glu Glu Asp Asp Asp 420 425 430 gct gac gat ttt gag tct gac tat gag gaa gaa agc tat cat ctt gct 1584 Ala Asp Asp Phe Glu Ser Asp Tyr Glu Glu Glu Ser Tyr His Leu Ala 435 440 445 ccc gaa gaa gta aac aaa gct cca gta ttt gta cct gtt ggtcct Pro Glu Glu Val Asn Lys Ala Pro Val Phe Val Pro Val Gly Leu Arg 450 455 460 tct cct gaa cct gtt tct gct cag att gag gaa aca atg gaa gag ctt 1680 Ser Pro Glu Pro Val Ser Ala Gln Ile Glu Glu Thr Met Glu Glu Leu 465 470 475 480 gaa ata act gtg aat gtc cca gat gta gga tgc ata gct gtt gtt gaa 1728 Glu Ile Thr Val Asn Val Pro Asp Val Gly Cys Ile Ala Val Val Glu 485 490 495 cat gag cta cca aac aca gat gtg act act gaa gaa atg aaa caa gaa 1776 His Glu Leu Pro Asn Thr Asp Val Thr Thr Glu Glu Met Lys Gln Glu 500 505 510 gaa aat ttg agt gta ccg ttt gaa atg acc aca agt gaa cat atc caa 1824 Glu Asn Leu Ser Val Pro Phe Glu Met Thr Thr Ser Glu His Ile Gln 515 520 525 gat gaa cca ggt acc aat gat gga agc acc gaa gct gca ata act tta 1872 Asp Glu Pro Gly Thr Asn Asp Gly Ser Thr Glu Ala Ala Ile Thr Leu 530 535 540 ctt aca atg gga gat cta gta ttg cag tca gag atc agt agt gaa cag 1920 Leu Thr Met Gly Asp Leu Val Leu Gln Ser Glu Ile Ser Ser Glu Gln 545 550 555 560 ggt gat gta gga gta tgt ata att cct cat gtt cat tca aag gat aaa 1968 Gly Asp Val Gly Val Cys Ile Ile Pro His Val His Ser Lys Asp Lys 565 570 575 agc cat att cct tct agc cta gat aat gta aat cac aaa att gtt cat 2016 Ser His Ile Pro Ser Ser Leu Asp Asn Val Asn His Lys Ile Val His 580 585 590 gaa tgt cag gaa ctt tct tca cct gtc att act aca tct cct gca tca 2064 Glu Cys Gln Glu Glu Leu Ser Ser Pro Val Ile Thr Thr Ser Pro Ala Ser 595 600 605 ttt gaa gaa aac aag att gta ttg gag gaa caa agt tcc aga gaa gaa 2112 Phe Glu Glu Asn Lys Ile Val Leu Glu Glu Gln Ser Ser Arg Glu Glu 610 615 620 ata agt tta atg gag aaa gta aag gag aat gct aca cca acc agg agg t 2160 Ile Ser Leu Met Glu Lys Val Lys Glu Asn Ala Thr Pro Thr Arg Asn 625 630 635 640 640 aca att tct aaa gtg acc agt aat ttg aga ata aga agt agg ctt gct 2208 Thr Ile Ser Lys Val Thr Ser Asn Leu Arg Ile Arg Ser Arg Leu Ala 645 650 655 aag cct aaa cca aat ctt gag aag act tta ggg acc aac agg ctt gat 2256 Lys Pro Lys Pro Asn Leu Glu Lys Thr Leu Gly Thr Asn Arg Leu Asp 660 665 670 gat tat cag gaa gtt tcc agt ttg tgt gta acc aaa ggg gca gaa atg 2304 Asp Tyr Gln Glu Val Ser Ser Leu Cys Val Thr Lys Gly Ala Glu Met 675 680 685 gaa act caa aga gaa aca gag aaa aat gct tcc aaa gca aca gaa ttg 2352 Glu Thr Gln Arg Glu Thr Glu Lys Asn Ala Ser Lys Ala Thr Glu Leu 690 695 700 gaa aat aaa aac ctc gga cca gtt aca aca gca gag aat aag gat cag 2400 Glu Asn Lys Asn Leu Gly Pro Val Thr Thr Ala Glu Asn Lys Asp Gln 705 710 715 720 agc aaa ttg gca tgt gta cat ggt atc aaa ggg acc agt att tct tca 2448 Ser Lys Leu Ala Cys Val His Gly Ile Lys Gly Thr Ser Ile Ser Ser 725 730 735 735 gaa gta aac cta act gaa aga aac gaa aat caa gaa gag agc tct cag 2496 Glu Val Asn Leu Thr Glu Arg Asn Glu Asn Gln Glu Glu Ser Ser Gln 740 745 750 gag gtt cac atg ttg tca gtt gct cca gtt gct tcc tct gag aca ggg 2544 Glu Val His Met Leu Ser Val Ala Pro Val Ala Ser Ser Glu Thr Gly 755 760 765 ccc tgc aca ctt ggt ttg gat agg ggt ctt ggt gaa aat tct gtt gaa 2592 Pro Cys Thr Leu Gly Leu Asp Arg Gly Leu Gly Glu Asn Ser Val Glu 770 775 775 780 gag ccc cag ata aag gac tct aaa gga gac agt gtg ctt aca ctt cct 2640 Glu Pro Gln Ile Lys Asp Ser Lys Gly Asp Ser Val Leu Thr Leu Pro 785 790 795 800 gtg cca gag tat aca cca aca agt att cca gaa gtc caa caagag aat 2688 Val Pro Glu Tyr Thr Pro Thr Ser Ile Pro Glu Val Gln Gln Glu Asn 805 810 815 ata atc aat cct caa gac cta aca gtg aat cta gtt gct aat gta cct 2736 Ile Ile Asn Pro Gln Asp Leu Thr Val Asn Leu Val Ala Asn Val Pro 820 825 830 caa gat gga gaa gat gaa caa gcc ttt att tta act ctg gtg gaa atc 2784 Gln Asp Gly Glu Asp Glu Gln Ala Phe Ile Leu Thr Leu Val Glu Ile 835 840 845 cca gcc aat gca gta gaa gaa ttt act gat gcc act gca cag ttc atg 2832 Pro Ala Asn Ala Val Glu Glu Phe Thr Asp Ala Thr Ala Gln Phe Met 850 855 860 cca aac cct tta ctg cca gct ccc ata ttg gtc aaa tca gtg aat acc 2880 Pro Pro Leu Leu Pro Ala Pro Ile Leu Val Lys Ser Val Asn Thr 865 870 875 880 gaa gaa agg ggt gac atg agt att tgt tta cca gca act tca gtt ggt 2928 Glu Glu Arg Gly Asp Met Ser Ile Cys Leu Pro Ala Thr Ser Val Gly 885 890 895 caa gat gcc atg ggt tta tct att tct gga aga gat aat tct aaa aag 2976 Gln Asp Ala Met Gly Leu Ser Ile Ser Gly Arg Asp Asn Ser Lys Lys Lys 900 905 910 ccg cct gat aat ttg gat ctt gta tct aag aga ttt caa tgc agg 3024 Pro Pro Asp Asn Leu Asp Leu Val Ser Arg Lys Arg Phe Gln Cys Arg 915 920 925 ctt gat aaa aat gac cac att cct cct gcc aaa aaa cgt tca ctc act 3072 Leu Asp Lys Asn Asp His Ile Pro Pro Ala Lys Lys Arg Ser Leu Thr 930 935 940 tta aga gat gac tgt caa gaa tat acc act gag gtg cac tca aag gaa 3120 Leu Arg Asp Asp Cys Gln Glu Tyr Thr Thr Glu Val His Ser Lys Glu 945 950 955 960 tta aca aat gtt ttt gag gaa aca ggg gag tct cac aag gga caa gat 3168 Leu Thr Asn Val Phe Glu Glu Thr Gly Glu Ser His Lys Gly Gln Asp 965 970 975 att ttt ctt acc tca gga agc aca ctg aca act cca gaa cct caa aga 3216 Ile Phe Leu Thr Ser Gly Ser Thr Leu Thr Thr Pro Glu Pro Gln Arg 980 985 990 cag caa gtt gaa gca gct ttt cag agt aga gga tct aga tct cct gat 3264 Gln Gln Val Glu Ala Ala Phe Gln Ser Arg Gly Ser Arg Ser Pro Asp 995 1000 1005 gca tgc atg gac aag aat gtg cct cag tta cct cag gat gaa atg att 3312 Ala Cys Met Asp Lys Asn Val Pro Gln Leu Pro Gln Asp Glu Met Ile 1010 1015 1020 gtg tct gat aaga gaa aga act gat gct gct cct aag tct cag caa 3360 Val Ser Asp Lys Glu Glu Arg Thr Asp Ala Ala Pro Lys Ser Gln Gln 1025 1030 1035 1040 atg gat agc aga aca tcg tct tct aaa gcc tca cta tcc aga cct ggc 3408 Asp Ser Arg Thr Ser Ser Ser Lys Ala Ser Leu Ser Arg Pro Gly 1045 1050 1055 aga aga ccc ctg gga ttt tta tct tta ata tgc tca aag aat agt ttg 3456 Arg Arg Pro Leu Gly Phe Leu Ser Leu Ile C ys Ser Lys Asn Ser Leu 1060 1065 1070 gag tct gat gaa cct atg caa gtc cat agt aag aaa cgc cta aaa cct 3504 Glu Ser Asp Glu Pro Met Gln Val His Ser Lys Lys Arg Leu Lys Pro 1075 1080 1085 ctt ata cct gga tta aga aag aaa ttg aaa aga tct aat cca ttc aat 3552 Leu Ile Pro Gly Leu Arg Lys Lys Leu Lys Arg Ser Asn Pro Phe Asn 1090 1095 1100 gaa agc cag gaa aaa aat cga gag tcc tct gat ctg ctt cca tctca 3 Gln Glu Lys Asn Arg Glu Ser Ser Asp Leu Leu Pro Ser Pro 1105 1110 1115 1120 agt gtt att act act caa tct gag aat att agc agc tca gca act cag 3648 Ser Val Ile Thr Thr Gln Ser Glu Asn Ile Ser Ser Ser Ala Thr Gln 1125 1130 1135 gtt tct tgt gat cag ccc tta ctg aaa gaa gga tat aaa agt gcc caa 3696 Val Ser Cys Asp Gln Pro Leu Leu Lys Glu Gly Tyr Lys Ser Ala Gln 1140 1145 1150 aag cgg gcc cct caa ggg gag gca accaca gtc tct gaa tat ttc ttc 3744 Lys Arg Ala Pro Gln Gly Glu Ala Thr Thr Val Ser Glu Tyr Phe Phe 1155 1160 1165 aat gat atc ttc att gaa gtg gat gaa aca gaa taaaacaatc ttttctcttt 379 7 Asn Asp Ile Phe Ile Glu Val Asp Glu Thr Glu 1170 1175 ttctttttta aattaggtct aggatttcca gagtcaatta catcaacaaa acagtattta 3857 gagcaaaata tcactgtctt atttttcttt aggttgattt tgaatactta atgagcttga 3917 tttgaagctt ttataatcag tggaaaacat ttctgaggtt cctttcattc tgactgattc 3977 agcattttgc aaatagcaag caattaagac tgctttctca gacagaaata acaactcttg 4037 tttacatttt gactcttcct gtgctaagca cacatggaca tttgggaatg ttgtggatat 4097 atgtctctgt atgaattgca gtgcagacag atttgggggt taattgtatc atatttaaca 4157 tttagcaact tcttttgtga agatttttta tttttagggg gagatgatga aggatgaagg 4217 ctttttcatt tgcttctaag tacagtcatg tatcacataa tgaagtttaa gtcaatgatg 4277 gaccacatat attacagtgg tcccatgcaa ttaaaatgga gataaattcc tatcaactag 4337 tgacattata gccatcataa cacagtgcat tgctttttta tgtttagata tgtttagata 4397 cacaaatact tactattgtg ttacaactgc ctacagtatt cagcatagta acacattgta 4457 gaggtttgta gccgaggagc aataggctat accacatagc ctcagtctgt acggtgtgta 4517 gcagcctgta ccatctcagt gtttgtaagt acactctgcg ttgtttcaca caagatcacc 4577 taacaaggca attcttagaa catgtagtta agggacacgt gactatatgt gaaaacaaat 4637 tgtcaaactt cactttagta tggcaaatgt taaagaactt ttctattatc agctgtttgt 4697 ctgactgaaa aatacatatt tttctaattc atggtgatgt aacattagtc ctaattgaaa 4757 aactagtatt taaacataat tatttataaa gatgacacat caaagggctt atttattttt 4817 aaatttttta tttaaaagga tattcagttt tagctatttt tacccctcag attgtagata 4877 aagaaggcat taaatttatg tttgtctcct ttttctgttt aattttaaag atatttaaaa 4937 tgatataact aaaaatgttt agctggtgta tatgttttga ataccttttt cccctcagtt 4997 tagtatattg actttgtact gtaaattttt ctgcttttct tggataatct caggattttc 5057 atgaggatag ggggaactca actttattta tgagacaaaa tttccataca aagctcaatc 5117 tcctttatac acccacagac ataatattag tttttaaaaa gccaatttct tcatagtttt 5177 ttcccattaa attctcaagg aacacttgga tctttaagca cggaacataa tcatgatgtt 5237 aaaaacagag aaaataaggc tttataaagt taatgattat catcagtatg aatttaaggt 5297 ttgttttaat ttcaagattt gattttttat acgtgtaatt ctattatcta cccaagcaga 5357 tctgtagtgg ttccaattag acttctcaaa cagcaaattt atcctgattt tatttgaaaa 5417 gcctcttgga ttgatagtat agta gctcag gcattggaaa ctttctgcaa actgttttgg 5477 gtttgcaggc cagatggtct ctgtggcagc tactcagctc tgcaatttca gtgtgaaaga 5537 agccatagac agtacttgaa tgaaggactg tggctggatt ggccttttag tttgaccccc 5597 tacattaggc cccaaatttt cttaccctga ggtgctgata tctgtatgga tgagttattt 5657 gtcactaaag ttatgagttg tgcctaaaag ttaaaactgt tgactgtatt atgtaatgat 5717 cagtatttca gttgggaaga tattttagag tctagataat tatgtttgta tattgaaaaa 5777 atggtggcca gtttttaagt tccttaatag aagagaatta tgtctcagca catataacag 5837 taatgctaat ttattgaaac tactgctgtt agagcacttc ttattcattg tcttttagtg 5897 aaatttatgg cgtaacactt tgtcagagag gaggctatat aattcggagc ggaaattgtc 5957 tataagtagg catttatttc atgattgata tgtcacagaa atcatggtag taaatcacat 6017 tgctatttga ataccctgtt tttgtaagtt tttaaaactc atattctgaa aagatttcat 6077 tctcttagtg ttagcttggg agttagattg ccatgattaa actattattt atccttgtgt 6137 aatattagtt tttaacttta acatctgttt ctttttaatc tataatgagc tagttttatg 6197 gaaaatggaa tttcttacta tataaagaat acagagactc attgtattag agaatcaagt 6257 cagccagcta aagtatccta ctgttaaatc cttaaaccta attttggaaa agagaaagtt 6317 aatcaatgta tttaccttac atgttggaaa gaactatgtt aggtctgatt catgtgaaga 6377 agatgttgca aaggatttat ttcacaaatt ttaaaggaga tatgagtaaa agtttttatc 6437 ttttcttgac tttttctcct gaacacttat gtcttagcaa gtggtcaaca tgaggatttg 6497 aacgcctaat tgttggtaaa tggttgaggc atgacaaaaa tattaatatc cactgtttac 6557 catcatgtta tttgaaacaa aagtgaccat gtatactatc ttgcttgaag aagtctttga 6617 cagaaaaagc aatatcatgt catttataaa ttttcttgtt ctaaagaaag cagttatata 6677 tatatataaa ttatgtaaat aaaagttatt ttatatc 6714 <210> 12 <211> 4815 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (555) .. (3710) <400> 12 ccgggggtgg cgaggggaag gcgacatttg cttggcgctg cctccgtgca gagcggccgg 60 gagggctttg cagcggccgc cgacgcggcg ggaggagggg gctgaggcgg cttcggagtt 120 ggccggagaa ggtgggcatt tctcgctttt cctccccttc ctgcgctctc cccctccctc 180 ctgccccgca ccccacgtga agcagaatat aaaggggggt gtgaggctag aggggaaagt 240 gaatggcgaa ggactgaagg gatcccccct tcgggtcccc ggccgccctg ttcaccctcg 300 ttcatcctcc tttccgaagc tcgctctcga aggcaggagc gaccggcgcc tttggctgag 360 gaggaggaga aggaggaatc gcgccaggcg gagcgtcagg tcccgttttc ctctccggcg 420 tctccaatac aaagattacg gtgcagaagg aaattgcact cgtctcctcc gcgcccccgg 480 tacccaacac aatgcaccag ccgcctgagt ccaccgccgc ggccgccgcc gctgcagaca 540 ttagcgctag gaag atg gcg cac ccg gca atg ttc cct cga agg ggc agc 590 Met Ala His Pro Ala Met Phe Pro Arg Arg Gly Ser 1 5 10 ggt agt ggc agc gcc tct gct ctc aat gca gca ggt acc ggc gtc ggt 638 Gly Ser Gly Ser Ala Ser Ala Leu Asn Ala Ala Gly Thr Gly Val Gly 15 20 25 agt aat gcc aca tct tcc gag gat ttt ccg cct ccg tcg ctg ctt ca Ser Asn Ala Thr Ser Ser Glu A sp Phe Pro Pro Pro Ser Leu Leu Gln 30 35 40 ccg ccg ccc cct gca gca tct tct acg tcg gga cca cag cct ccg cct 734 Pro Pro Pro Pro Ala Ala Serla Thr Ser Gly Pro Gln Pro Pro Pro 45 50 55 60 cca caa agc ctg aac ctc ctt tcg cag gct cag ctg cag gca cag cct 782 Pro Gln Ser Leu Asn Leu Leu Ser Gln Ala Gln Leu Gln Ala Gln Pro 65 70 75 ctt gcg cca ggc gga act caa atg aaa aag aaa agt ggg ccc ata 830 Leu Ala Pro Gly Gly Thr Gln Met Lys Lys Lys Ser Gly Phe Gln Ile 80 85 90 act agc gtt act cct gct cag atc tcc gct agt atc agc tct aac aac 878 Thr Ser Val Thr Pro Ala Gln Ile Ser Ala Ser Ile Ser Ser Asn Asn 95 100 105 agt ata gca gag gac act gag agc tat gat gat ctg gat gaa tct cac 926 Ser Ile Ala Glu Asp Thr Glu Ser Tyr Asp Asp Leu Asp Glu Ser His 110 115 120 acg gaa gat ctc tct tct tcg gag atc ctt gat gtg tca ctt tcc agg 974 Thr Glu Asp Leu Ser Ser Ser Glu Ile Leu Asp Val Ser Leu Ser Arg 125 130 135 140 gct act gac tta ggg gag ccc gaa cgc agc tcc tca gaa gag acc cta 1022 Ala Thr Asp Leu Gly Glu Pr o Glu Arg Ser Ser Ser Glu Glu Thr Leu 145 150 155 aat aac ttc cag gaa gcc gag aca cct ggg gca gtc tct ccc aac cag 1070 Asn Asn Phe Gln Glu Ala Glu Thr Pro Gly Ala Val Ser Pro Asn Gln 160 165 170 ccc cac ctt cct cag cct cat ttg cct cac ctt cca caa cag aat gtt 1118 Pro His Leu Pro Gln Pro His Leu Pro His Leu Pro Gln Gln Asn Val 175 180 185 gtg atc aat ggg aat gct cat cca cac cac ctc cat cac cac cat cag 1166 Val Ile Asn Gly Asn Ala His Pro His His Leu His His His His Gln 190 195 200 att cat cat ggg cac cac ctc caa cat ggt cac cac cat cca tct cat 1214 Ile His His Gly His His Leu Gln His Gly His His His Pro Ser His 205 205 215 220 gtt gct gtg gcc agt gca tcc att act ggt ggg cca ccc tca agc cca 1262 Val Ala Val Ala Ser Ala Ser Ile Thr Gly Gly Pro Pro Ser Ser Pro 225 230 235 gta tct aga aaa ctc tct aca act gga agc tct gac agt atc aca cca 1310 Val Ser Arg Lys Leu Ser Thr Thr Gly Ser Ser Asp Ser Ile Thr Pro 240 245 250 gtt gca cca act tct gct gta tca tcc agt ggt tca cct gca tct gta 1358 Val Ala Pro Thr Ser Ala Val Ser Ser Ser Gly Ser Pro Ala Ser Val 255 260 265 atg act aat atg cgt gct cca agt act aca ggt gga ata ggt ata aat 1406 Met Thr Asn Met Arg Ala Pro Ser Thr Thr Gly Gly Ile Gly Ile Asn 270 275 280 tct gtt act ggc act agt aca gta aat aat gtt aac att act gct gtg 1454 Ser Val Thr Gly Thr Ser Thr Val Asn Asn Val Asn Ile Thr Ala Val 285 290 295 300 ggt agt ttt aat cct aat gtg aca agc agc atc ctt ggt aat gtt aat 1502 Gly Ser Phe Asn Pro Asn Val Thr Ser Ser Ile Leu Gly Asn Val Asn 305 310 315 ata agt aca agc aat att cct agt gct gct ggt gtg agt gtt ggg cct 1550 Ile Ser Thr Ser Asn Ile Pro Ser Ala Ala Gly Val Ser Val Gly Pro 320 325 330 gga gtt acc agt ggt gtt aat gtg aat atc ttg agt ggc atg ggc aat 1598 Gly Val Thr Ser Gly Val Asn Val Asn Ile Leu Ser Gly Met Gly Asn 335 340 345 ggt act att tct tcc tct gct gct gtt agc agt gtt cct aat gca gct 1646 Gly Thr Ile Ser Ser Ser Ala Ala Val Ser Ser Val Pro Asn Ala Ala 350 355 360 gca ggg atg act ggg gga tcg gtt tca agt cag cag caa caa c ca aca 1694 Ala Gly Met Thr Gly Gly Ser Val Ser Ser Gln Gln Gln Gln Pro Thr 365 370 375 380 gtt aac act tcg agg ttc aga gtt gtg aag tta gat tct agt tct gag 1742 Val Asn Thr Ser Arg Phe Arg Val Val Lys Leu Asp Ser Ser Ser Glu 385 390 395 ccc ttt aaa aaa ggt aga tgg act tgc act gag ttc tat gaa aaa gaa 1790 Pro Phe Lys Lys Gly Arg Trp Thr Cys Thr Glu Phe Tyr Glu Lys Glu 400 405 410 aat gct gta cct gct aca gaa ggt gtg ctg ata aat aaa gtg gtg gag 1838 Asn Ala Val Pro Ala Thr Glu Gly Val Leu Ile Asn Lys Val Val Glu 415 420 425 act gta aag caa aat ccg ata gaa gtg act tct gaa agg gag agc act 1886 Val Lys Gln Asn Pro Ile Glu Val Thr Ser Glu Arg Glu Ser Thr 430 435 440 agt ggg agt tca gtg agc agt agt gtc agc aca ctg agt cac tat aca 1934 Ser Gly Ser Ser Val Ser Ser Ser Val Ser Thr Leu Ser His Tyr Thr 445 450 455 460 gag agt gtg gga agt gga gag atg gga gcc cct act gtg gtg gtg cag 1982 Glu Ser Val Gly Ser Gly Glu Met Gly Ala Pro Thr Val Val Val Gln 465 470 475 cag cag cag cag caa caa caa caa ca a cag caa caa cca gct ctc caa 2030 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Ala Leu Gln 480 485 490 490 ggt gtg acc ctc caa cag atg gat ttt ggt agc act ggt cca cag agt 2078 Gly Val Thru Gln Gln Met Asp Phe Gly Ser Thr Gly Pro Gln Ser 495 500 505 att cca gca gtt agt ata cca cag agt att tct cag tca cag atc tca 2126 Ile Pro Ala Val Ser Ile Pro Gln Ser Ile Ser Gln Ser Gln Ile Ser 510 515 520 caa gta caa tta cag tct caa gaa ctg agc tat cag caa aag caa ggt 2174 Gln Val Gln Leu Gln Ser Gln Glu Leu Ser Tyr Gln Gln Lys Gln Gly 525 530 535 535 540 ctt cag cca gta cct ctg caa gcc act atg agt act ggt atc 2222 Leu Gln Pro Val Pro Leu Gln Ala Thr Met Ser Ala Ala Thr Gly Ile 545 550 555 cag cca tcg cct gta aat gtg gtt ggt gta act tca gct tta ggt cag 2270 Gln Pro Ser Pro Val Asn Val Val Gly Val Thr Ser Ala Leu Gly Gln 560 565 570 cag cct tcc att tcc agt ttg gct caa ccc cag cta cca tat tct cag 2318 Gln Pro Ser Ile Ser Ser Leu Ala Gln Pro Gln Leu Pro Tyr Ser Gln 575 580 585 gcg gct cct cca gtg caa act ccc ctt cca ggg gca cca cca ccc caa 2366 Ala Ala Pro Pro Val Gln Thr Pro Leu Pro Gly Ala Pro Pro Pro Gln 590 595 600 cag tta cag tat gga caa cag caa cca atg gtt tct aca cag atg gcc 2414 Gln Leu Gln Tyr Gly Gln Gln Gln Pro Met Val Ser Thr Gln Met Ala 605 610 615 620 cca ggc cat gtc aaa tca gtg act caa aat cct gct tca gag tat gta 2462 Pro Gly His Val Lys Ser Val Thr Gln Asn Pro Ala Ser Glu Tyr Val 625 630 635 caa cag cag cca att ctt caa aca gca atg tcc tcc gga cag ccc agt 2510 Gln Gln Gln Pro Ile Leu Gln Thr Ala Met Ser Ser Gly Gln Pro Ser 640 645 650 tct gca gga gta gga gca gga aca aca gtg att cct gtg gct cag cca 2558 Ser Ala Gly Val Gly Ala Gly Thr Thr Val Ile Pro Val Ala Gln Pro 655 660 665 cag ggt atc cag ctg cca gtg cag ccc aca gca gtc cca gca caa cct 2606 Gln Gly Ile Gln Leu Pro Val Gln Pro Thr Ala Val Pro Ala Gln Pro 670 675 680 gca ggg gca tct gtc cag cct gtt ggc cag gct ccg gca gca gtg tct 2654 Ala Gly Ala Ser Val Gln Pro Val Gly Gln Ala Pro Ala Ala Val Ser 685 690 695 700 gct gta cct act ggc agt cag att gca aat att ggt cag caa gca aac 2702 Ala Val Pro Thr Gly Ser Gln Ile Ala Asn Ile Gly Gln Gln Ala Asn 705 710 715 ata cct act gca gtg cag cag ccc tct acc cag gtt cca cct tca gtt 2750 Ile Pro Thr Ala Val Gln Gln Pro Ser Thr Gln Val Pro Pro Ser Val 720 725 730 att cag cag ggt gct cct cca tct tcg caa gtg gtt cca cct gct caa 2798 Ile Gln Gln Gly Ala Pro Pro Ser Ser Gln Val Val Pro Pro Ala Gln 735 740 745 act ggg att att cat cag gga gtt caa act agt gct cca agc ctt cct 2846 Thr Gly Ile Ile His Gln Gly Val Gln Thr Ser Ala Pro Ser Leu Pro 750 755 760 caa caa ttg gtt att gca tcc caa agt tcc ttg tta act gtg cct ccc 2894 Gln Gln Leu Val Ile Ala Ser Gln Ser Ser Leu Leu Thr Val Pro Pro 765 770 770 775 780 cag cca caa gga gta gaa cca gta gct caa gga att gtt tca cag cag 2942 Gln Pro Gln Gly Val Glu Pro Val Ala Gln Gly Ile Val Ser Gln Gln 785 790 795 ttg cct gca gtt agt tct ttg ccc tct gct agt agt att tct gtt aca 2990 Leu Pro Ala Val Ser Ser Leu Pro Ser Ala Ser Ser I le Ser Val Thr 800 805 810 agt cag gtt agt tca act ggt cct tct gga atg cct tct gcc cca aca 3038 Ser Gln Val Ser Ser Thr Gly Pro Ser Gly Met Pro Ser Ala Pro Thr 815 820 825 aac ttg gtt cca cca caa aat ata gca caa acc cct gct acc caa aat 3086 Asn Leu Val Pro Pro Gln Asn Ile Ala Gln Thr Pro Ala Thr Gln Asn 830 835 840 ggt aat ttg gtt caa agt gtt agt caa cct ccc ttg ata gca act aat 3134 Gly Asn Leu Val Gln Ser Val Ser Gln Pro Pro Leu Ile Ala Thr Asn 845 850 855 860 aca aat ttg cct ttg gca caa cag ata cca cta agt tct acc cag ttc 3182 Thr Asn Leu Pro Leu Ala Gln Gln Ile Pro Leu Ser Ser Thr Gln Phe 865 870 875 tcc gca caa tca tta gct cag gca att gga agc caa att gaa gat gcc 3230 Ser Ala Gln Ser Leu Ala Gln Ala Ile Gly Ser Gln Ile Glu Asp Ala 880 885 890 890 agg cgt gca gcg gag ccc tcc tta gtt ggc cag act atc agt 3278 Arg Arg Ala Ala Glu Pro Ser Leu Val Gly Leu Pro Gln Thr Ile Ser 895 900 905 ggt gac agt ggg gga atg tca gca gtt tca gat ggg agt agc agc agc 3326 Gly Asp Ser Gly Gly Met Ser A la Val Ser Asp Gly Ser Ser Ser Ser 910 915 920 cta gca gcc tct gct tct ctt ttc ccg ttg aag gtg cta ccg ctg acg 3374 Leu Ala Ala Ala Ser Ala Ser Leu Phe Pro Leu Lys Val Leu Pro Leu Thr 925 930 930 935 940 aca ccc ctg gtg gat ggc gag gat gag agc tcc tct ggt gca agt gtg 3422 Thr Pro Leu Val Asp Gly Glu Asp Glu Ser Ser Ser Gly Ala Ser Val 945 950 955 gta gct att gac aac aaa atc gag caa gct atg gat cta gtg aaa agc 3470 Val Ala Ile Asp Asn Lys Ile Glu Gln Ala Met Asp Leu Val Lys Ser 960 965 970 cat ttg atg tat gcg gtc aga gaa gaa gtg gag gtc ctc aaa gag caa 3518 His Leu Met Tyr Ala Val Arg Glu Glu Val Leu Lys Glu Gln 975 980 985 atc aaa gaa cta ata gag aaa aat tcc cag ctg gag cag gag aac aat 3566 Ile Lys Glu Leu Ile Glu Lys Asn Ser Gln Leu Glu Gln Glu Asn Asn 990 995 1000 ctg ctg ag aca gtg cct gag cag ctt gcc cag ttt cag gcc 3614 Leu Leu Lys Thr Leu Ala Ser Pro Glu Gln Leu Ala Gln Phe Gln Ala 1005 1010 1015 1020 cag ctg cag act ggc tcc ccc cct gcc acc acc cag cca cag ggc acc 3662 G ln Leu Gln Thr Gly Ser Pro Pro Ala Thr Thr Gln Pro Gln Gly Thr 1025 1030 1035 aca cag ccc ccc gcc cag cca gca tcg cag ggc tca gga cca acc gca 3710 Thr Gln Pro Pro Ala Gln Pro Ala Ser Gln Gly Ser Gly Pro Thr Ala 1040 1045 1050 tagctgccta tgcccccgca gaactggctg ctgcgtgtga actgaacaga cggagaagat 3770 gtgctaggga gaatctgcct ccacagtcac ccatttcatt gctcgctgcg aaagagacgt 3830 gagactgaca tatgccatta tctctttttc cagtattaaa cactcatatg cttatggctt 3890 ggagaaattt cttagttggg tgaattaaag gttaatccga gaattagcat ggatataccg 3950 ggacctcatg cagcttggca gatatctgag aaatggttta attcatgctc aggagctgtg 4010 tgcctttcca tcccttccgg ctccctaccc ctcacttcca agggttctct ctcctgcttg 4070 cgcttagtgt cctacatggg gttgtgaagc gatggagctc ctcactggac tcgcctctct 4130 cctctcctcc ccccaggagg aacttgaaag gagggtaaaa agactaaaat gagggggaac 4190 agagttcact gtacaaattt gacaactgtc accaaaattc ataaaaaaca atagtactgt 4250 gcctctttct tctcaaacaa tggatgacac aaaactatga gagtgacaaa atggtgacag 4310 gtagctggga cctaggctat cttaccatga aggttgtttt gcttattgta tatttgtg ta 4370 tgtagtgtaa ctattttgta caatagagga ctgtaactac tatttaggtt gtacagattg 4430 aaatttagtt gtttcattgg ctgtctgagg aggtgtggac ttttatatat agatctacat 4490 aaaaactgct acatgacaaa aaccacacct aaagaaattt taagaatttg gcacagttac 4550 tcactttgtg taatctgaaa tctagctgct gaatacgctg aagtaaatcc ttgttcactg 4610 aagtctttca attgagctgg ttgaatactt tgaaaaatgc tcagttctaa ctaatgaaat 4670 ggatttccca gtaggggttt ctgcatatca cctgtatagt agttatatgc atatgtttct 4730 gtgcatgttc tctacacaat tgtaaggtgt cactgtattt aactgttgca cttgtcaact 4790 ttcaataaag catataaatg ttgat 4815 <210> 13 <211> 5492 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (11) .. (3043) <400> 13 gctgggctga cgg atc cgc ggg ccg gca tct gaa gcg agc ggg acg cag 49 Arg Ile Arg Gly Pro Ala Ser Glu Ala Ser Gly Thr Gln 1 5 10 cgc ggc cag ggc ctc cgg gca tac gca ggc tgg tcc ccc gcg 97 Arg Gly Gln Gly Leu Arg Ala Tyr Ala Gly Trp Ser Pro Arg Pro Ala 15 20 25 gcc gcc gcc atg tcg gtg ctg ggc gag tac gag cga cac tgc gat tcc 145 Ala Ala Ala Met Ser Val Leu Gly Glu Tyr Glu Arg His Cys Asp Ser 30 35 40 45 atc aac tcg gac ttt ggg agc gag tcc ggg ggt tgc ggg gac tcg agt 193 Ile Asn Ser Asp Phe Gly Ser Glu Ser Gly Gly Cys Gly Asp Ser Ser 50 55 60 ccg ggg cct agc gcc agt cag ggg ccg cga gcc ggc ggc ggc gcg gcg 241 Pro Gly Pro Ser Ala Ser Gln Gly Pro Arg Ala Gly Gly Gly Ala Ala 65 70 75 gag cag gag gaa ctg cac tac atc ccc atc cgc gtc ctg ggc cgc ggclnc Glu Leu His Tyr Ile Pro Ile Arg Val Leu Gly Arg Gly 80 85 90 gcc ttc ggg gaa gcc acg ctg tac cgc cgc acc gag gat gac tca ctg 337 Ala Phe Gly Glu Ala Thr Leu Tyr Arg Arg Thr Glu Asp Asp Ser Leu 95 100 105 gtt gtg tgg aag gaa gtc gat ttg acc cgg ctg tct gag aag gaa cgt 385 Val Val Trp Lys Glu Val Asp Leu Thr Arg Leu Ser Glu Lys Glu Arg 110 115 120 125 cgt gat gcc ttg aat gag att gtt att ctg gca ctg ctg cag cat gac Arg Asp Ala Leu Asn Glu Ile Val Ile Leu Ala Leu Leu Gln His Asp 130 135 140 aac att att gcc tac tac aat cac ttc atg gac aat acc acg ctg ctg 481 Asn Ile Ile Ala Tyr Tyr Asn His Phe Met Asp Asn Thr Thr Leu Leu 145 150 155 att gag ctg gaa tat tgt aat gga ggg aac ctg tat gac aaa atc ctt 529 Ile Glu Leu Glu Tyr Cys Asn Gly Gly Asn Leu Tyr Asp Lys Ile Leu 160 165 170 cgt cag aag gac aag ttg tg gag atg gtg gtg tgg tac cta 577 Arg Gln Lys Asp Lys Leu Phe Glu Glu Glu Met Val Val Trp Tyr Leu 175 180 185 ttt cag att gtt tca gca gtg agc tgc atc cat aaa gct gga atc ctt 625 Phe Gln Ile Ser A Val Ser Cys Ile His Lys Ala Gly Ile Leu 190 195 200 205 cat aga gat ata aag aca tta aat att ttt ctg acc aag gca aac ctg 673 His Arg Asp Ile Lys Thr Leu Asn Ile Phe Leu Thr Lys Ala Asn Leu 210 215 220ata aaa ctt gga gat tat ggc cta gca aag aaa ctt aat tct gag tat 721 Ile Lys Leu Gly Asp Tyr Gly Leu Ala Lys Lys Leu Asn Ser Glu Tyr 225 230 235 tcc atg gct gag acg ctt gtg gga acc cca tat tac atg cca gag 769 Ser Met Ala Glu Thr Leu Val Gly Thr Pro Tyr Tyr Met Ser Pro Glu 240 245 250 ctc tgt caa gga gta aag tac aat ttc aag tct gat atc tgg gca gtt 817 Leu Cys Gln Gly Val Lys Tyr Asn Phe Lys Ser Asp Ile Trp Ala Val 255 260 265 ggc tgc gtc att ttt gaa ctg ctt acc tta aag agg acg ttt gat gct 865 Gly Cys Val Ile Phe Glu Leu Leu Thr Leu Lys Arg Thr Phe Asp Ala 270 275 280 285 285 aca aac cca cac acac ctg tgt gtg aag atc gtg caa gga att cgg gcc 913 Thr Asn Pro Leu Asn Leu Cys Val Lys Ile Val Gln Gly Ile Arg Ala 290 295 300 atg gaa gtt gac tct agc cag tac tct ttg gaa ttg atc caaetglu 96 Val Asp Ser Ser Gln Tyr Ser Leu Glu Leu Ile Gln Met Val 305 310 315 cat tcg tgc ctt gac cag gat cct gag cag aga cct act gca gat gaa 1009 His Ser Cys Leu Asp Gln Asp Pro Glu Gln Arg Pro Thr Ala Asp Glu 320 325 330 ctt cta gat cgc cct ctt ctc agg aaa cgc agg aga gag atg gag gaa 1057 Leu Leu Asp Arg Pro Leu Leu Arg Lys Arg Arg Arg Glu Met Glu Glu 335 340 345 aaa gtc act ctg ctt aat gca ccacaca cca agg tca agc act 1105 Lys Val Thr Leu Leu Asn Ala Pro Thr Lys Arg Pro Arg Ser Ser Thr 350 355 360 365 gtg act gaa gca ccc att gct gta gta aca tca cga acc agt gaa gtc 1153 Val Thr Glu Ala Pro Ile Ala Val Val Thr Ser Arg Thr Ser Glu Val 370 375 380 tat gtt tgg ggt ggt gga aaa tcc acc ccc cag aaa ctg gat gtt atc 1201 Tyr Val Trp Gly Gly Gly Lys Ser Thr Pro Gln Lys Leu Asp Val Ile 385 390 395 aag agt ggc tgt agt gcc cgg cag gtc tgt gca ggg aat acc cac ttt 1249 Lys Ser Gly Cys Ser Ala Arg Gln Val Cys Ala Gly Asn Thr His Phe 400 405 410 gct gtg gtc aca gtg gag aag gaa ctg tac act tgg gtg aac cag 1297 Ala Val Val Thr Val Glu Lys Glu Leu Tyr Thr Trp Val Asn Met Gln 415 420 425 gga ggc act aaa ctc cat ggt cag ctg ggc cat gga gac aaa gcc tcc 1345 Gly Gly Thr Lys Leu His Gly Gln Leu Gly His Gly Asp Lys Ala Ser 430 435 440 445 tat tat cga cag cca aag cat gtg gaa aag ttg caa ggc aaa gct atc cat 1393 Tyr Arg Gln Pro Lys His Val Glu Lys Leu Gln Gly Lys Ala Ile His 450 455 460 cag gtg tca tgt gat gat ttc act gtc tgt gtg act gat gag ggt 1441 Gln Val Ser Cys Gly Asp Asp Phe Thr Val Cys Val Thr Asp Glu Gly 465 470 475 cag ctc tat gcc ttc gga tca gat tat tat ggc tgc atg ggg gtg gac 1489 Gln Tyr Ala Phe Gly Ser Asp Tyr Tyr Gly Cys Met Gly Val Asp 480 485 490 aaa gtt gct ggc cct gaa gtg cta gaa ccc atg cag ctg aac ttc ttc 1537 Lys Val Ala Gly Pro Glu Val Leu Glu Pro Met Gln Leu Asn 495 500 505 ctc agc aat cca gtg gag cag gtc tcc tgt gga gat aat cat gtg gtg 1585 Leu Ser Asn Pro Val Glu Gln Val Ser Cys Gly Asp Asn His Val Val 510 515 520 525 gtt ctg aca cga aac aag gaa gtc tat tgg ggc tgt ggc gaa tat 1633 Val Leu Thr Arg Asn Lys Glu Val Tyr Ser Trp Gly Cys Gly Glu Tyr 530 535 540 gga cga ctg ggt ttg gat tca gaa gag gat tat tat aca cca caa aag 1681 Gly Arg Leu Gly Le Asp Ser Glu Glu Asp Tyr Tyr Thr Pro Gln Lys 545 550 555 gtg gat gtt ccc aag gcc ttg att att gtt gca gtt caa tgt ggc tgt 1729 Val Asp Val Pro Lys Ala Leu Ile Ile Val Ala Val Gln Cys Gly Cys 560 565 570 gat ggg aca ttt ctg ttg acc cag tca ggc aaa gtg ctg gcc tgt gga 1777 Asp Gly Thr Phe Leu Leu Thr Gln Ser Gly Lys Val Leu Ala Cys Gly 575 580 585 585 ctc aat gaa ttc aat aag ctg ggt cg atg gga att 1825 Leu Asn Glu Phe Asn Lys Leu Gly Leu Asn Gln Cys Met Ser Gly Ile 590 595 600 605 atc aac cat gaa gca tac cat gaa gtt ccc tac aca acg tcc ttt acc 1873 Ile Asn His Glu Ala Tyr His Glu Val Pro Tyr Thr Thr Ser Phe Thr 610 615 620 ttg gcc aaa cag ttg tcc ttt tat aag atc cgt acc att gcc cca ggc 1921 Leu Ala Lys Gln Leu Ser Phe Tyr Lys Ile Arg Thr Ile Ala Pro Gly 625 630 630 635 aag act cac aca gct gct att gat gag cga ggc cgg ctg ctg acc ttt 1969 Lys Thr His Thr Ala Ala Ile Asp Glu Arg Gly Arg Leu Leu Thr Phe 640 645 650 ggc tgc aac aag tgt ggg cag ctg ggc gtt ggg aac tac aag aag cgt 2017 ly Cys Asn Lys Cys Gly Gln Leu Gly Val Gly Asn Tyr Lys Lys Arg 655 660 665 ctg gga atc aac ctg ttg ggg gga ccc ctt ggt ggg aag caa gtg atc 2065 Leu Gly Ile Asn Leu Leu Gly Gly Pro Leu Gly Gly Val Ile 670 675 680 685 agg gtc tcc tgc ggt gat gag ttt acc att gct gcc act gat gat aat 2113 Arg Val Ser Cys Gly Asp Glu Phe Thr Ile Ala Ala Thr Asp Asp Asn 690 695 700 cac att ttt gcc tgg ggc aat ggt ggt aat ggc cgc ctg gca atg acc 2161 His Ile Phe Ala Trp Gly Asn Gly Gly Asn Gly Arg Leu Ala Met Thr 705 710 715 ccc aca gag aga cca cat ggc tct gat atc tgt acc tca tgg cct cgg 2209 Pro Thr Glu Arg Pro His Gly Ser Asp Ile Cys Thr Ser Trp Pro Arg 720 725 730 cct att ttt gga tct ctg cat cat gtc ccg gac ctg tct tgc cgt gga 2257 Pro Ile Phe Gly Ser Leu His His Val Pro Asp Leu Ser Cys Arg Gly 735 740 745 tgg cat acc att ctc atc gtt gag aaa gta ttg aat tct aag acc atc 2305 Trp His Thr Ile Leu Ile Val Glu Lys Val Leu Asn Ser Lys Thr Ile 750 755 760 760 cgt tcc aat agc agt ggc tta tcc att gga act gt g ttt cag agc tct 2353 Arg Ser Asn Ser Ser Gly Leu Ser Ile Gly Thr Val Phe Gln Ser Ser 770 775 780 agc ccg gga gga ggc ggc ggg ggc ggc ggt ggt gaa gaa gag gac agt 2401 Ser Pro Gly Gly Gly Gly Gly Gly Gly Gly Glu Glu Glu Asp Ser 785 790 795 cag cag gaa tct gaa act cct gac cca agt gga ggc ttc cga gga aca 2449 Gln Gln Glu Glu Ser Glu Thr Pro Asp Pro Ser Gly Gly Phe Arg Gly Thr 800 805 810 atg gaa gca gac cga gga atg gaa ggt tta atc agt ccc aca gag gcc 2497 Met Glu Ala Asp Arg Gly Met Glu Gly Leu Ile Ser Pro Thr Glu Ala 815 820 825 atg ggg aac agt aat ggg gcc agc agc tcc tgt cct ggc tgg ctt Met Gly Asn Ser Asn Gly Ala Ser Ser Ser Cys Pro Gly Trp Leu Arg 830 835 840 845 aag gag ctg gaa aat gca gaa ttt atc ccc atg cct gac agc cca tct 2593 Lys Glu Leu Glu Asn Ala Glu Phe Ile Pro Met Pro Asp Ser Pro Ser 850 855 860 cct ctc agt gca gcg ttt tca gaa tct gag aaa gat acc ctg ccc tat 2641 Pro Leu Ser Ala Ala Phe Ser Glu Ser Glu Lys Asp Thr Leu Pro Tyr 865 870 875 875 gaa gag ctg caa gga ctc aaa gtg gcc tct gaa gct cct ttg gaa cac 2689 Glu Glu Leu Gln Gly Leu Lys Val Ala Ser Glu Ala Pro Leu Glu His 880 885 890 890 aaa ccc caa gta gaa gcc tcg tca cct cgg ctg aat cct gca gta acc 2737 Lys Pros Glu Ala Ser Ser Pro Arg Leu Asn Pro Ala Val Thr 895 900 905 tgt gct ggg aag gga aca cca ctg act cct cct gcg tgt gcg tgc agc 2785 Cys Ala Gly Lys Gly Thr Pro Leu Thr Pro Pro Ala Cys Ala Cys Ser 910 915 920 925 tct ctg cag gtg gag gtt gag aga ttg cag ggt ctg gtg tta aag tgt 2833 Ser Leu Gln Val Glu Val Glu Arg Leu Gln Gly Leu Val Leu Lys Cys 930 935 940 ctg gct gaa caa cag aag cta cag caa cac caacac caa cac caa cac caa cac caa cac caa cac caa cac caa cac caa cac caa cac caa cac caa cac caa cac caca gac cag att ttt acc 2881 Leu Ala Glu Gln Gln Lys Leu Gln Gln Glu Asn Leu Gln Ile Phe Thr 945 950 955 caa ctg cag aag ttg aac aag aaa tta gaa gga ggg cag cag gtg ggg 2929 Gln Leu Gln Lys Leu Asn Lys Glu Gly Gly Gln Gln Val Gly 960 965 970 atg cat tcc aaa gga act cag aca gca aag gaa gag atg gaa atg gat 2977 Met His Ser Lys Gly Thr Gln Thr Ala Lys Glu Glu Met Glu Met Asp 975 980 985 cca aag cct gac tta gat tca gat tcc tgg tgc ctc ctg gga aca gac 3025 Pro Lys Pro Asp Leu Asp Ser Asp Ser Trp Cys Leu Leu Gly Thr Asp 990 995 1000 1005 tcc tgt aga ccc agc ctc tagtctcctg agcc tataga gccccg Leu 1010 gactgggacc caaagaactt cacagcacac ttaccgaatg cagagagcag ctttcctggc 3133 tttgttcact tgcagaaaag gagcgcaagg cagaggctct gaagcacttt ccttgtacat 3193 ttggagagtg gcattgcctt ttagatagga tctaggagtg attttattgt tttggagaat 3253 ggaagggccc ccatggccct ggctttgtca tcagtgactg ccatagcaac agcagctctg 3313 tacctcatct gttgatccca cctttgaaga ggagacacag tgctcacctt aattgcgctg 3373 gtagcagctt atatcccatg tatcattttc accattgatt ggaagctgcc ttgggaattc 3433 agtaccaggc attacccctc tgggtgggag agggagaagt gtaaagttgg agtgggctgg 3493 aatcaggtgt ggcccgccca gtgtcctctg cagagtggtg aagtagtctg gccctcttgg 3553 gagccctgag tccaggaaaa tatgtctgat ggagtcaatc tagggcttgt ttcgaaaagg 3613 ttcaggtag ttggttagtag ggtgatgagtag ctgga tg gg cctcatcat 3733 cacacagctg gtgtttcagg ctgtgaccaa tgcagggtgg gatttcctaa ctgtggatga 3793 ggggatgagg tgtctctgag ggatgaggtg tctcagagaa ttgagtccat ggggcagtca 3853 gaatagcctt aagagaaaat catgaaggag aagaggtcct cctttagctg cctctacttg 3913 gtatcttaga gagggcttag agggctctca gtcttctgcc catgaaaaga cttctttgag 3973 cctctgcctt catggctctt agggttctga tcttgatatc agcagcccca accactttct 4033 ttctgaatgt ctagtcagta tttttcccct tttggtgttt tatgaagcca tgtggtaacg 4093 aatgaatctg tatcattttt cctacctgag tggcccaaag ccagcaccaa accctgggag 4153 tccctgaagc ctaacagaac aggtagaact tgcaaaagga atttggctga gagctcactt 4213 ctaatcctgt actcactgtg tctttgtaga tagaaacaag ctagctttac caaagagaaa 4273 tagtgtcata gaagaacaaa acttcatata gaaagttcta ggcaagtatt tgatggtttc 4333 cttaaggatg tgagctttgt atttccacct agccttgtaa aatgttcctg tggtattttg 4393 tgtcacacat cctacctttg atgagtctca catcccacct tcctataaac agctaaatta 4453 attttgtttc atcttcccca gaccaaaatg tttgataatc ttatcaacat tgtgggaggt 4513 cttgtgcaat ggaaattttg ccatttctcc aaaactggtg gcataaaggc tgatgct tgg 4573 ggagaacccc attgctcggg acaggcaact ctgttcaatg ggatcttctt tggtttgatg 4633 ttcccattgt tttctcagtt ctgggaagcc tagtacatta gtactaatgt aatcactgaa 4693 accttttctt gaaataaggg aagcagccaa actttgatta aagttgcaag ttctggggac 4753 ttgcgggggt tgtcataaac tgtaacagtg gggttttggt tcagcatgta aatgcaactt 4813 tgattttctt gaggaccgat tgacctgtca tgtccctgta tcctcatgct catcatctca 4873 gcaggcctga gaggctgggt cagtttgggt gttcatcatg aggattgctt ctgccatgga 4933 gctgatggac gtgggcaggt tgctgagaag gtggggtgaa agtgagtgcc gggggtgggt 4993 gagtgccctg gtcttgttca taggggagcc tttccctagc agtggaacgc tgtggtcatt 5053 ttctctagca tattcccttg ggaagtctag atttgctatt aatctggctg agaatctaag 5113 ttctgtgcct tagagacagt ttgcactttc ccatattgtg cctgggacag ccatatgatt 5173 ttttttccca ccaaacaagt atgcaaacag aaaccagttc aaagggggat ggagtaaaag 5233 atgaggcagt agaaatgcct ttgaatggtt ttctgtagct aattctcttt aaattttgtc 5293 ctgctttttt tctttatgca gtgctaggtg ttttaagttt tctagtagta ttgcttttga 5353 gttacagtat aacctgagtt actcctctgc tctaacattg ttgcagaaga actagtttat 54 13 tgttagccag gttgcttgaa aggttgagag tggagtggtt tggcatttct gttttaaata 5473 aacatttaag ctcttaatc 5492 <210> 14 <211> 3567 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2407) <400> 14 g tgc cgc ttc cta ttg ggg cct ccc cag ggc ggg agt ccc cgc ggg tct 49 Cys Arg Phe Leu Leu Gly Pro Pro Gln Gly Gly Ser Pro Arg Gly Ser 1 5 10 15 cat cac aca agt ggg tcg tcc ctg tca aca ccc cgg tcc cgt ggc gga 97 His His Thr Ser Gly Ser Ser Leu Ser Thr Pro Arg Ser Arg Gly Gly 20 25 30 act tcc cag gtg ggc tcc cca acc ttg ctg tct cca gct gtg cca tca 145 Thr Ser Gln Val Gly Ser Pro Thr Leu Leu Ser Pro Ala Val Pro Ser 35 40 45 aag cag aaa agg gac agg agc atc ctc acg ctg tct aaa gag cca ggg 193 Lys Gln Lys Arg Asp Arg Ser Ile Leu Thr Leu Ser Lys Glu Pro Gly 50 55 60 cac cag aaa ggc aaa gag cgt cgg tcc gtg ctg gag tgc aga aat aag 241 His Gln Lys Gly Lys Glu Arg Arg Ser Val Leu Glu Cys Arg Asn Lys 65 70 75 80 ggg gtc ctg atg ttc cca gaa aaa tct ccc t cta acc cag 289 Gly Val Leu Met Phe Pro Glu Lys Ser Pro Ser Ile Asp Leu Thr Gln 85 90 95 tca aat cct gac cat tcg agc tcc aga tct cag aaa tct tca tcc aaa 337 Ser Asn Pro Asp His Ser Ser Ser Arg Ser Gln Lys Ser Ser Ser Lys 100 105 1 10 ctg aac gaa gaa gat gag gtc atc ctc tta ctg gac tcg gat gag gag 385 Leu Asn Glu Glu Asp Glu Val Ile Leu Leu Leu Asp Ser Asp Glu Glu 115 120 125 ctg gag cta gaa caa acc aaa atg act tcc at gat cct ctg 433 Leu Glu Leu Glu Gln Thr Lys Met Lys Ser Ile Ser Ser Asp Pro Leu 130 135 140 gaa gaa aag aaa gct cta gaa att agc cct agg tcc tgt gag ctg ttt 481 Glu Glu Lys Lys Ala Leu Glu Ile Ser Pro Arg Ser Cys Glu Leu Phe 145 150 155 160 tcc atc att gat gtt gat gca gat cag gaa cct tcc cag agc cca cca 529 Ser Ile Ile Asp Val Asp Ala Asp Gln Glu Pro Ser Gln Ser Pro Pro 165 170 175 aga agc gaa gct gtg ctg cag cag gag gat gag ggg gcg ctg ccg gag 577 Arg Ser Glu Ala Val Leu Gln Gln Glu Asp Glu Gly Ala Leu Pro Glu 180 185 190 aat cgg ggc tct ttg ggc agg aga ggg gct ccc tgg gtg ttc ttg gtg ttc gtg gtc Arg Gly Ser Leu Gly Arg Arg Gly Ala Pro Trp Leu Phe Cys Asp 195 200 205 cgt gag agc agc ccc agc gag gcc agc acc aca gac acc tcg tgg ctg 673 Arg Glu Ser Ser Pro Ser Glu Ala Ser Thr Thr Asp Thr Ser Trp L eu 210 215 220 gtg ccc gcc acc ccg ctg gcc agc aga agc cgt gac tgt tct tcc cag 721 Val Pro Ala Thr Pro Leu Ala Ser Arg Ser Arg Asp Cys Ser Ser Gln 225 230 235 240 acc caa atc agc agc ctc agg agc ggg ctg gcc gtg cag gcg gtg act 769 Thr Gln Ile Ser Ser Leu Arg Ser Gly Leu Ala Val Gln Ala Val Thr 245 250 255 cag cac acg ccc agg gcc tca gta gga aac agg gaa ggg aac gaa gtc 817 Gln His Thr Pro Arg Ala Ser Val Gly Asn Arg Glu Gly Asn Glu Val 260 265 270 gca cag aag ttt tct gtc atc agg ccc cag aca cca ccg ccc cag aca 865 Ala Gln Lys Phe Ser Val Ile Arg Pro Gln Thr Pro Pro Pro Gln Thr 275 280 285 ccg tcc tca tgc ctc act ccc gtc tct cca gga act tct gac ggc aga 913 Pro Ser Ser Cys Leu Thr Pro Val Ser Pro Gly Thr Ser Asp Gly Arg 290 295 300 agg caa ggc cac aga agc cct tcc cgt ccc cac ccc ggg ggc cac ccg 961 Arg Gln Gly His Arg Ser Pro Ser Arg Pro His Pro Gly Gly His Pro 305 310 315 320 cac tcc tct ccg ctg gct cca cat ccc atc tca ggg gac cgc gcc cac 1009 His Ser Ser Pro Leu Ala Pro His Pro Ile SerGly Asp Arg Ala His 325 330 335 ttc agc agg cgg ttc ctg aaa cac tcg ccg cct ggg cca agc ttc ctg 1057 Phe Ser Arg Arg Phe Leu Lys His Ser Pro Pro Gly Pro Ser Phe Leu 340 345 350 aac cag acc cca gg gaa gtg gtg gaa gtc gga gac agt gac gat 1105 Asn Gln Thr Pro Ala Gly Glu Val Val Glu Val Gly Asp Ser Asp Asp 355 360 365 gag cag gag gtg gcc tcc cat cag gcc aac aga agc ccc cca ctg gac Glu Gln Val Ala Ser His Gln Ala Asn Arg Ser Pro Pro Leu Asp 370 375 380 agt gac ccc cca att cca att gac gac tgc tgc tgg cac atg gag ccc 1201 Ser Asp Pro Pro Ile Pro Ile Asp Asp Cys Cys Trp His Met Glu Pro 385 390 395 400 ctc tcg cca att ccc att gac cac tgg aac ctg gag cgg acc ggc ccc 1249 Leu Ser Pro Ile Pro Ile Asp His Trp Asn Leu Glu Arg Thr Gly Pro 405 410 415 ctg agc acc agc agc ccc agc agc atg atg gag gcc gcc gac agc 1297 Leu Ser Thr Ser Ser Pro Ser Arg Arg Met Asn Glu Ala Ala Asp Ser 420 425 430 cgt gac tgt cgc tcc ccg gga ctc ctg gac acc acc ccc atc cga gga 1345 Arg Asp Cys Arg Ser Pro G ly Leu Leu Asp Thr Thr Pro Ile Arg Gly 435 440 445 agc tgc act acc cag agg aaa ttg caa gag aag tcc tcg ggc gcg ggc 1393 Ser Cys Thr Thr Gln Arg Lys Leu Gln Glu Lys Ser Ser Gly Ala Gly 450 455 460 460 tcc ctg ggg aac agc agg ccg agc ttt ctg aat tcg gct ctg tgg gac 1441 Ser Leu Gly Asn Ser Arg Pro Ser Phe Leu Asn Ser Ala Leu Trp Asp 465 470 475 480 480 gtt tgg gac ggg gaa gag cag agg cct ccagag ccg gcc 1489 Val Trp Asp Gly Glu Glu Gln Arg Pro Pro Glu Thr Pro Pro Pro Ala 485 490 cag atg cca agc gct ggt gga gct cag aag ccc gaa ggg tta gag aca 1537 Gln Met Pro Ser Ala Gly Gly Ala Gln Lys Pro Glu Gly Leu Glu Thr 500 505 510 ccc aaa ggt gct aat cgg aag aag aac ttg ccc ccc aaa gtg ccc ata 1585 Pro Lys Gly Ala Asn Arg Lys Lys Asn Leu Pro Pro Lys Val Pro Ile 515 520 525 acg ccg atg cca cag tat tcc att atg gag acg ccg gtg ctg aag aag 1633 Thr Pro Met Pro Gln Tyr Ser Ile Met Glu Thr Pro Val Leu Lys Lys 530 535 540 gaa ctg gat agg ttt gga gtc cgc cct ctg cct aaa cgc cag atg Gtt 1681 Glu eu Asp Arg Phe Gly Val Arg Pro Leu Pro Lys Arg Gln Met Val 545 550 555 560 ctg aag ctg aag gag ata ttc cag tac act cac cag acc ctg gac tca 1729 Leu Lys Leu Lys Glu Ile Phe Gln Tyr Thr His Gln Thr Leu Asp Ser 565 570 575 gac tcc gag gac gag agc cag tcc tca cag ccg ctg ttg cag gcg cct 1777 Asp Ser Glu Asp Glu Ser Gln Ser Ser Gln Pro Leu Leu Gln Ala Pro 580 585 590 cac tgc cag acc ctc gcc tcc ca acc tac aag cct tca agg gca ggg 1825 His Cys Gln Thr Leu Ala Ser Gln Thr Tyr Lys Pro Ser Arg Ala Gly 595 600 605 gtc cat gcc cag cag gag gcc acc aca gga cct ggg gcc cat agg ccc 1873 Val His Ala Gln Gln Glu Ala Thr Thr Gly Pro Gly Ala His Arg Pro 610 615 620 aag gga cct gct aag acc aag ggc ccc cga cat caa agg aag cat cat 1921 Lys Gly Pro Ala Lys Thr Lys Gly Pro Arg His Gln Arg Lys His His 625 630 635 640 gaa agc atc aca ccc cca agc agg tcg ccc acc aag gag gca cct cca 1969 Glu Ser Ile Thr Pro Pro Ser Arg Ser Pro Thr Lys Glu Ala Pro Pro 645 650 655 ggc ctc aat gat gac gcc cag atc cca gcc tct caa gaa tcc gtg gcc 2017 Gly Leu Asn Asp Asp Ala Gln Ile Pro Ala Ser Gln Glu Ser Val Ala 660 665 670 acc tct gtg gat ggc agt gac agc tcc ttg agc tca cag agt tct tcc 2065 Thr Ser Val Asp Gly Ser Asp Ser Ser Leu Ser Ser Gln Ser Ser Ser 675 680 685 tcc tgt gag ttt gga gcg gca ttt gag tct gca ggt gaa gag gag ggc 2113 Ser Cys Glu Phe Gly Ala Ala Phe Glu Ser Ala Gly Glu Glu Glu Gly 690 695 700 gag ggg gag gtc agt gcc tcg cag gca gcc gtg cag gcg gcg gac aca 2161 Glu Gly Glu Val Ser Ala Ser Gln Ala Ala Val Gln Ala Ala Asp Thr 705 710 715 720 gac gag gcg ctg agg tgc tac atc cgc tcc aag ccg gcc ctg tcc Glu Ala Leu Arg Cys Tyr Ile Arg Ser Lys Pro Ala Leu Tyr Gln 725 730 735 aag gtg ctg ctg tac cag ccc ttt gag ctg cgg gag ctg cag gca gag 2257 Lys Val Leu Leu Tyr Gln Pro Phe Glu Leu Arg Glu Leu Glu 740 745 750 ctg agg cag aac ggc ctc cgt gtg tcc tcg cgc agg ctg ttg gac ttc 2305 Leu Arg Gln Asn Gly Leu Arg Val Ser Ser Arg Arg Leu Leu Asp Phe 755 760 765 ctg gac acc cac tgt acc act gcc gcc acc cgc agg gag 2353 Leu Asp Thr His Cys Ile Thr Phe Thr Thr Ala Ala Thr Arg Arg Glu 770 775 780 aag ctc cag ggc agg agg cgg cag cct cgg ggc aag aag aag gtg gag 2401 Lys Leu Gln Gly Arg Arg Arg Gln Pro Arg Gly Lys Lys Lys Val Glu 785 790 795 800 cgg aac tgatggggcc atcccgaccc caccccaacc tgccatcagc agcccccacc 2457 Arg Asn cccgccattt gcagggagga cctgggacac ccagcgtggg tcaggcctcc acaggcattt 2517 ctgggcctgg ggaccacatc agctctgcgc tgtgatgatg accacagccc aatccagggc 2577 ttcctcctct gggctctgct ttctagggtg gcatttggag catgtcaccc actggattta 2637 cagactccag ccccttcctc tgtccgtgct cacagtgtgt ctcccttttt ggttttcttt 2697 ttttttttct ttttgagaca gtcgtgctgt gtcacctagg ctggagtgca gtggcacaat 2757 ctcggctcac tgcaacctcc gcctcccggg ttcaagcaat tctcctgcct cagcctccca 2817 gatagctggg actacaggca cacgctgcca cgcccagctg attttttata ttttagtaga 2877 aacggggttt caccatgttg ctcaggctgg tcacaaactc cagagctcag gcaatccgcc 2937 tgctgcggcc tcccaaagtg ctgggatcac aggcgccagc cactgcgccc ggcccagtgt 2997 gtctccctta acccaagagg gccctcagct gtcccagggg gcagtgggcc atcaccagct 3057 ggccagggca tggcctattc tgccacattt gccaccctct gagcccacca gtcctgggca 3117 cagctgccct acatgtctgt cctgagatgg acgtcaggtc cagcctgccc cggcagcccg 3177 ggcccgtcct cctcagcact caggccaacc ccagccaccg ccagcctgag accaggtgtc 3237 ctgaggctcc ctgcactgcc acagcccaga tgcagttctc ctgacccagc cgtgctaccc 3297 ggacacttgt cattgttacc agcagtctcc aaactggaca gtgcacaagg gcccagaaca 3357 actctgatgc caccacaaaa caaacatgtt cactagcgga ttccattctt tgggttaaag 3417 ctgcctccag cctcaggagc agtgtggagg aagatgaggg ccaggaaaga aggaaacctt 3477 ggtttctcca tccttgtgaa tgtcctcgtc tgtttcaaat acagtgcagt cagttttata 3537 tgatgtgcaa taaaccaaaa aggctttatt 3567 <210> 15 <211> 3682 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (159) .. (1469) <400> 15 accggacagg ccttgtccgg caataccaag tttcatgcag gctcttggga aagctggtgc 60 tgctgctgcc tgattcccgc cgacagacct tgggaccggg gccaacactg gcagctggag 120 atggcggaca cgagatccgt gcacgagact aggtttga ggc ggc cgt gaa ggt gat 176 Gly Gly Arg Glu Gly Asp 1 5 cca gag ttt gcc gaa gaa tgg gat gct tgg agt tca ctg ggt gat atg 224 Pro Glu Phe Ala Glu Glu Trp Asp Ala Trp Ser Ser Leu Gly Asp Met 10 15 20 acc aaa gag gaa gcc atg att gca tat gtt gaa gaa atg aaa aag att 272 Thr Lys Glu Glu Glu Ala Met Ile Ala Tyr Val Glu Glu Met Lys Lys Ile 25 30 35 att gaa act atg cca atg act gag aaa gtt gaa gaa ttg ctg cgt gtc 320 Ile Glu Thr Met Pro Met Thr Glu Lys Val Glu Glu Leu Leu Arg Val 40 45 50 ata ggt cca ttt tat gaa att gtc gag gac aaa aag agt ggc agg agt 368 Ile Gly Pro Phe Tyr Glu Ile Val Glu Asp Lys Lys Ser Gly Arg Ser 55 60 65 70 tct gat ata acc tca gat ctt ggt aat gtt ctc act tct act cca aac 416 Ser Asp Ile Thr Ser Asp Leu Gly Asn Val Leu Thr Ser Thr Pro Asn 75 80 85 gcc aaa acc gtt aat ggt aaa gct gaa agc agt g ac agt gga gcc gag 464 Ala Lys Thr Val Asn Gly Lys Ala Glu Ser Ser Asp Ser Gly Ala Glu 90 95 100 tct gag gaa gaa gag gcc caa gaa gaa gtg aaa gga gca gaa caa agt 512 Ser Glu Glu Glu Glu Alu Gln Glu Glu Val Lys Gly Ala Glu Gln Ser 105 110 115 gat aat gat aag aaa atg atg aag aag tca gca gac cat aag aat ttg 560 Asp Asn Asp Lys Lys Met Met Lys Lys Ser Ala Asp His Lys Asn Leu 120 125 130 gaa gtc att gtc act aat ggc tat gat aaa gat ggc ttt gtt cag gat 608 Glu Val Ile Val Thr Asn Gly Tyr Asp Lys Asp Gly Phe Val Gln Asp 135 140 145 150 ata cag aat gac att cat gcc agt tct tcc ctg aat ggc aga agc act 656 Ile Gln Asn Asp Ile His Ala Ser Ser Ser Leu Asn Gly Arg Ser Thr 155 160 165 gaa gaa gta aag cct att gat gaa aac ttg ggg caa act gga aaa tct 704 Glu Glu Val Lys Pro Ile Asp Glu Asn Leu Gly Gln Thr Gly Lys Ser 170 175 180 gct gtt tgc att cac caa gat ata aat gat gat cat gtt gaa gat gtt 752 Ala Val Cys Ile His Gln Asp Ile Asn Asp Asp His Val Glu Asp Val 185 190 195 aca gga att cag cat ttg aca agc gat tca gac agt gaa gtt tac tgt 800 Thr Gly Ile Gle His Leu Thr Ser Asp Ser Asp Ser Glu Val Tyr Cys 200 205 210 gat tct atg gaa caa ttt gga caa gaa gag tct tta gac agc ttt acg 848 Asp Ser Met Glu Gln Phe Gly Gln Glu Glu Ser Leu Asp Ser Phe Thr 215 220 225 230 tcc aac aat gga cca ttt cag tat tac ttg ggt ggt cat tcc agt caa 896 Ser Asn Asn Gly Pro Phe Gln Tyr Tyr Leu Gly Gly His Ser Ser Gln 235 240 245 ccc atg gaa aat tct gga ttt cgt gaa gat att caa gta cct cct gga 944 Pro Met Glu Asn Ser Gly Phe Arg Glu Asp Ile Gln Val Pro Pro Gly 250 255 260 aat ggc aac att ggg aat atg cag gtg gtt gca gtt gaga gga aaa ggt 992 Asn Gly Asn Ile Gly Asn Met Gln Val Val Ala Val Glu Gly Lys Gly 265 270 275 gaa gtc aag cat gga gga gaa gat ggc agg aat aac agc gga gcg cca 1040 Glu Val Lys His Gly Gly Glu Asp Gg Asn Ser Gly Ala Pro 280 285 290 cac cgg gag aag cga ggc gga gaa act gat gaa ttc tct aat gtt aga 1088 His Arg Glu Lys Arg Gly Gly Glu Thr Asp Glu Phe Ser Asn Val Arg 295 300 305 310 310 aga gga aga gga c at agg atg caa cac ttg agc gaa gga acc aag ggc 1136 Arg Gly Arg Gly His Arg Met Gln His Leu Ser Glu Gly Thr Lys Gly 315 320 325 cgg cag gtg gga agt gga ggt gat ggg gag cgc tgg ggc tcc gac aga 1 Gln Val Gly Ser Gly Gly Asp Gly Glu Arg Trp Gly Ser Asp Arg 330 335 340 ggg tcc cga ggc agc ctc aat gag cag atc gcc ctc gtg ctg atg aga 1232 Gly Ser Arg Gly Ser Leu Asn Glu Gln Ile Ala Leu Val Leu Arg 345 350 355 ctg cag gag gac atg cag aat gtc ctt cag aga ctg cag aaa ctg gaa 1280 Leu Gln Glu Asp Met Gln Asn Val Leu Gln Arg Leu Gln Lys Leu Glu 360 365 370 acg ctg act gct ttg cag gca aaa aca tca aca ttg cag act 1328 Thr Leu Thr Ala Leu Gln Ala Lys Ser Ser Thr Ser Thr Leu Gln Thr 375 380 385 390 gct cct cag ccc acc tca cag aga cca tct tgg tgg ccc ttc gag atg 1376 Ala Pro Gln Pro Thr Ser Gln Arg Pro Ser Trp Trp Pro Phe Glu Met 395 400 405 tct cct ggt gtg cta acg ttt gcc atc ata tgg cct ttt att gca cag 1424 Ser Pro Gly Val Leu Thr Phe Ala Ile Ile Trp Pro Phe Ile Ala Gln 410 415 42 0 tgg ttg gtg tat tta tac tat caa aga agg aga aga aaa ctg aac 1469 Trp Leu Val Tyr Leu Tyr Tyr Gln Arg Arg Arg Arg Lys Leu Asn 425 430 435 tgaggaaaat ggtgttttcc tcaagaagac tactggaact ggatgacctc agaatgaact 1529 ggattgtggt gttcacaaga aaatcttagt ttgtgatgat tacattgctt tttgttgtcc 1589 agtagtttag tttgtgtaca tatatacaca tatatatttt gcactacaca aacgataaca 1649 ttttaaggac taatattgct gatacttgaa taatcaatct ctactaggtt ataagtagta 1709 tacacagatt taccctgccc ttgaacttga aggacattaa attattaatg atcatttggt 1769 aacatgttta cctgattatc ttccatagag taacataagc tgcttttcaa aggtaccatt 1829 gtgataatga gatcaaattt ataagttatt atttttaatt ttctaaatta aataaaagaa 1889 agaatgcaaa ccaggagtga atttcaaatg agatgtaatc gactttatat cttagtcacg 1949 gagttgccat ggcatgtagt agaaaaccac aggaagaatg gtcatattca ctttgtgggc 2009 tgcccataat ctttcttggg cattcacaac tcttgagttt ggtgttcagg catcattatt 2069 aaaaagtgga gtcctatgta ccagactgag tttttacaaa tgatttgcag gctagacata 2129 acccactgat ggaaatggtg aagaatgagc ttcatgtagg tttaaaagtg tattctgagat 2189 a ttaatcaggt ttttattcaa tcatataaat gtattccttt gtaatcattt 2249 ttgtttaact gaggatatct agtgtctgct tcatagggtg ctttgaaata taaaatgaaa 2309 acttatttat actgttttta caacagtcaa aaaggaaaca cacgaaaatc acttttctgc 2369 aactgatgaa ctatatagac tggactctta acctcttagt gcctcagttt ttccttcggg 2429 gtatactatt ttagatacac ctacttcaca ggagtactgg agggatttgc aagctaacgg 2489 gccaaatgct tccataggaa taaggcatgc ccagctaaca gaaatttaag tccctcttcc 2549 ccacctctct catctagacc aaaaagaaga ctacaattta gatccttgga gacttttcct 2609 gtatgccttc caaaacttcc tgctcactta gatgtacctt gtgctttgaa gatttctttg 2669 atgcagtctt tgtaacaaat aatttttttt tttaaatgga gtttctctct tgttgcccag 2729 gctggagggc aatggcgtga tcttggctca ctgcaacttc cacctcctgg gttcaagtga 2789 ttctcctgcc tcactcccaa gtagctggga ttacaggcat gcaccaccat gcctggctaa 2849 ttttgtattt ttagtagaga cggggtttct ccatgttggt aaggctgatc tcaaactccc 2909 aacctcaggt gatctgcctg cctcggcctc ccaaagtgct gggattagag gcgtgagcca 2969 ctgcacctgg cctgtagcaa ataattttta agcattctca agatgtatga tgttgggttt 3029 aacatcatat gtt cacagtg ttttaaataa gaaataatct gtctttagta tacaggatgg 3089 ttctttgttt gcctgaaaag tataagaata caatttactt ttcccaaact ctttttcctt 3149 atttttttct ttcaaataac tttaattatt taatcccata ctgattaaaa tatgtctgtc 3209 taaagggatc tactactatt tgcttttaaa aaagtgttcc ctatttattt aggaaaaagt 3269 gaagcaagca actgaattta tatgtaaaaa taacatttag acctgtggat caaagattat 3329 tttcaaaaat gagatatcaa tttggtatca gtaaaaagtg tcttttctct tagtatataa 3389 ataaataaaa tgcaaattaa gagtgtaagc agttgtgaat cattacaagc agtctgggat 3449 aactaactcc tagggataac catttctatc ctgttccaaa gtcttatttt atagtttgaa 3509 aagcactttg cacacagttc ttgtatataa aagtaaagat gtaattatag gatatagtgt 3569 tcctgctttg tttaataaga acctcattta aacttgacag ctatggtatt tttattgat attagtatt gattatt gatatt gtt <210> 16 <211> 4356 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2068) <400> 16 c cgc agt ccg ctc cct ccc gct ccg ctc gcc cct gcc cgc ccg ccc gcc 49 Arg Ser Pro Leu Pro Pro Ala Pro Leu Ala Pro Ala Arg Pro Pro Ala 1 5 10 15 cgg tcg cgc ggt cgc cgc cgc cac cgt gtc gcc cgc atc ctc cgc ctg 97 Arg Ser Arg Gly Arg Arg Arg His Arg Val Ala Arg Ile Leu Arg Leu 20 25 30 gcg cct cca ggc ccc gtg cct ccg ccc gcc ctc tcc ggc ccc ggc Gac Pro La Ala Val Pro Pro Pro Ala Leu Ser Gly Pro Gly Asp 35 40 45 gag gta acg cgc cct ggg ccg agc cgc cgg gcc ctc cgc cca gag cgc 193 Glu Val Thr Arg Pro Gly Pro Ser Arg Arg Ala Leu Arg Pro Glu Arg 50 55 60 cgc cct ccg agc tcg ccc cgg tgg gtg tgg ccc ggc ctg tcc cgt gcc 241 Arg Pro Pro Ser Ser Pro Arg Trp Val Trp Pro Gly Leu Ser Arg Ala 65 70 75 80 ccg ctg ccg cac ttc ggt ccc tcc cga gcc ccg cat ttc ggc 289 Pro Leu Pro His Phe Gly Pro Ser Arg Ala Pro Pro Pro His Phe Gly 85 90 95 ctc ctc cgg ccg ccc gta gct cca gtt ccc ctt tcc cca cca cgg agc 337 Leu Leu Arg Pro Pro Val Ala Pro Val Pro Leu Ser Pro Pro Arg Ser 100 105 1 10 ccc agg gcc cct ggg ctt gtc gag atg tct gag gcg tca gga aat ctc 385 Pro Arg Ala Pro Gly Leu Val Glu Met Ser Glu Ala Ser Gly Asn Leu 115 120 125 aac agc ctc cgc atg gcg aat gtg gcc ctg gcc tta aat gcc 433 Asn Ser Leu Arg Met Ala Asn Val Ala Leu Arg Glu Glu Leu Asn Ala 130 135 140 ctt cgc ggg gag aat gcc aat ttg ggc ctc cag ctc ggg aga gcc ctg 481 Leu Arg Gly Glu Asn Ala Leu Gu Gln Leu Gly Arg Ala Leu 145 150 155 160 gcc gag gtt aat tcc ttg cgg ggc aat gtc tcc agc tac atc cgc tgg 529 Ala Glu Val Asn Ser Leu Arg Gly Asn Val Ser Ser Tyr Ile Arg Trp 165 170 175 cca gta ccc ata gtg ccc gtc ctt gcg gag gag aac ttg gag ttc gcg 577 Pro Val Pro Ile Val Pro Val Leu Ala Glu Glu Asn Leu Glu Phe Ala 180 185 190 ctc agt gag atc gaa gtc att ccc ggg gga gaa ctg ccc ttc ttc ttc ttc ttc ttc ttc ttc ttg Ser Glu Ile Glu Val Ile Pro Gly Gly Glu Leu Pro Phe Leu Cys 195 200 205 cgg cct ccc cca cgc gcg gag ccc gac tgt atc tcg gat gat ctt ttg 673 Arg Pro Pro Pro Arg Ala Glu Pro Asp Cys Ile Ser Asp Asp LeuLeu 210 215 220 att aac gtg atc cag gat cgc agc acc ccc gac ggg ccc gct gac ccc 721 Ile Asn Val Ile Gln Asp Arg Ser Thr Pro Asp Gly Pro Ala Asp Pro 225 230 235 240 cct ctg ctg ccc atc ccg ccc ccg ccg gcg ctg cct ccg ccc gcg tca 769 Pro Leu Leu Pro Ile Pro Pro Pro Pro Ala Leu Pro Pro Pro Ala Ser 245 250 255 aag gaa ccg ccc ccg caa ccc cct ctg gca ccg ctg gag cgg cct gag 817 Lys Glu Pro Pro Gln Pro Pro Leu Ala Pro Leu Glu Arg Pro Glu 260 265 270 ata gag ccc ttt tca gga gac cca gtc tac ctg gct gaa ttc ctg atg 865 Ile Glu Pro Phe Ser Gly Asp Pro Val Tyr Leu Ala Glu Phe Leu Met 275 280 285 cag cta gag acc ttc ata gcc gac cat gag gtt cat ttc ccc ggg ggc 913 Gln Leu Glu Thr Phe Ile Ala Asp His Glu Val His Phe Pro Gly Gly 290 295 300 gcc gag cgg gtg gcc ttt ctg atc tcc ttt ttc act ggc gaga gcc aag 961 Ala Glu Arg Val Ala Phe Leu Ile Ser Phe Phe Thr Gly Glu Ala Lys 305 310 315 320 gac tgg gcc atc tcg gtc acc cag gaa gga agc ccc ttg cat gcc aac 1009 Asp Trp Ala Ile Ser Val Thr Gln Glu Gly Ser Pro Leu His Ala Asn 325 330 335 ttc ccg cgc ttc ctg gat gaa atc cgt aag gaa ttc tgt ggc ccc atc 1057 Phe Pro Arg Phe Leu Asp Glu Ile Arg Lys Glu Phe Cys Gly Pro Ile 340 345 350 ccc ccagt aag gcc att cgc aag ctc aag cag ggc cac 1105 Pro Pro Arg Val Ala Lys Lys Ala Ile Arg Lys Leu Lys Gln Gly His 355 360 365 tgt acc ctc ggc agc tat gca gat gct ttt cag ttc ctg gcc caa ttc 1153 Cy Gly Ser Tyr Ala Asp Ala Phe Gln Phe Leu Ala Gln Phe 370 375 380 ttg tct tgg gat gac tgc cgc ctc caa aac caa ttc ctc aaa ggc ctg 1201 Leu Ser Trp Asp Asp Cys Arg Leu Gln Asn Gln Phe Leu 390 395 400 tcg gaa ttc ttc cgc aaa gag ctc tta tgg tca aca gaa atg gcc gac 1249 Ser Glu Phe Phe Arg Lys Glu Leu Leu Trp Ser Thr Glu Met Ala Asp 405 410 415 ctg gat gag ctg att ctcg g gaa aga aaa gtg cgc 1297 Leu Asp Glu Leu Ile Leu Glu Cys Val Glu Ile Glu Arg Lys Val Arg 420 425 430 gtt ccc aag cct atc ccg ctc cct gga gtt cga aat atc atc ttc cct 1345 Val Pro Lys Pro Ile Pro Leu Pro Gly Val Arg Asn Ile Ile Phe Pro 435 440 445 ttt gct ccg agt ccc aat gag gaa gaa agt gaa gat gaa gag tac tac 1393 Phe Ala Pro Ser Pro Asn Glu Glu Glu Ser Glu Asp Glu Glu Tyr Tyr 450 455 460 agt gaa gat gaa gac caa gag gca cgc agg cac agg ctt cac tcc aag 1441 Ser Glu Asp Glu Asp Gln Glu Ala Arg Arg His Arg Leu His Ser Lys 465 470 470 475 480 gac cag agg aag cgc atg agg gct ttt cag caa gag atg gag aag 1489 Asp Gln Arg Lys Arg Met Arg Ala Phe Gln Gln Glu Met Lys Glu Lys 485 490 495 gag gag gag gag atg aag aag gag gaa gaa atg aag aag aag gaa gag 1537 Glu Glu Glu Glu Met Glu Glu Glu Glu Lys Lys Lys Glu Glu 500 505 510 aag gag gag gag gag gaa gag gaa atg aaa cag aaa gag gag gag gag 1585 Lys Glu Glu Glu Glu Glu Glu Glu Met Lys Gln Lys Glu Glu Glu Glu 515 520 525 gag ata aag aac gag gag gaa gga gag agt aag gat gaa gaa 1633 Glu Ile Arg Asn Lys Asn Glu Glu Glu Gly Glu Ser Lys Asp Glu Glu 530 535 540 gat gaa gat gag gat ggg ggc cag aaa cca gaa gga gag cca cag cag cag cag cag 1 Glu Asp Glu Asp Gly Gly Gln Lys Pro Glu Gly Glu Pro Gln Gln 545 550 555 560 gat cca ggg act gag gag acc tat ggt gag gtg gag gag gag cca ctg 1729 Asp Pro Gly Thr Glu Glu Thr Tyr Gly Glu Val Glu Glu Glu Pro Leu 565 570 575 gat gag gcc caa gat gat gac cta gat gag ctg atg gag atg gag ccg 1777 Asp Glu Ala Gln Asp Asp Asp Leu Asp Glu Leu Met Glu Met Glu Pro 580 585 590 acc ttt gtt cac gcg tca tcc ca tct ggc ccc aca agt ggt tac 1825 Thr Phe Val His Ala Ser Ser Gln Thr Ser Gly Pro Thr Ser Gly Tyr 595 600 605 cac gcc gaa aac ttc ctg ggt gca tca cct ccc ata ata cag cct agc 1873 His Ala Glu Asn Phe Leu Gly Ala Ser Pro Pro Ile Ile Gln Pro Ser 610 615 620 aga cgg agg aac cag aat cga gtc cca ctt ctg gaa ggc ctt cca ggc 1921 Arg Arg Arg Asn Gln Asn Arg Val Pro Leu Leu Glu Gly Leu Pro Gly 625 630 635 640 acc aat tca cca ttc tac agc tcc ccc caa ctg att cgc cgc aca ggt 1969 Thr Asn Ser Pro Phe Tyr Ser Ser Pro Gln Leu Ile Arg Arg Thr Gly 645 650 650 655 cgt tta ggg caa cgc caa gtt cga aga cgt ccc cct gt g ctt ttc cgc 2017 Arg Leu Gly Gln Arg Gln Val Arg Arg Arg Pro Pro Val Leu Phe Arg 660 665 670 ctc act ccg aga cag ggg ggc cac cga gct gct cgt ggc cga att cga 2065 Leu Thr Pro Arg Gln Gly Gly His Arg Ala Ala Arg Gly Arg Ile Arg 675 680 685 gtt tgagtgctgg ggccagatgg ccacccagaa cacacccttc ttttgcatcc 2118 Val cccgcccctg ctattgctgc catacctgcc ccatttgctg accaggactt cagggagttt 2178 cagacctgca gaacctgaag aagacctgca gaattccaga ccatcttgca accgtgacca 2238 gagagcgacg tgtgcccaac cagggccacc tgggaaagga gggatcagca atagctgccc 2298 tcttggcatg tactctgctc agtccggcca cgagctggag agcaagtttc tgggcctgtt 2358 cccataaatg aactggtcac cctcttgtat ttcccctctg gttgttccta accctcacct 2418 ctcctgcgtt tcttcaccct atgttctaca gttttattct ctgactgacc caccaggact 2478 tcacccaatg cctcactgat ctgccccaat gagcaagagg acaggctacc ctgaactcct 2538 aaagccactg aggccagttg ctagatataa tcgatggtga gcaggatggt atccagaaat 2598 gtccctagaa gcctacactc atttcatgcc acacctccag cagagggcct ggaagaggac 2658 ccgacatcta gcccagtgag agtgtgcaaa gccacatgtc aaatggac aa cttgacggag 2718 atttgccctt gactgactgt gcaggctggt tccacttaca gcacttgagt ttacctttgc 2778 acagattcct gtatcagggc tcttggactg acttgccaca catctggagc cctttcctct 2838 caccacattg ccctcctggg cacccccggt ggacagcgcc caacattgca ggctccacaa 2898 ctttccttga tgttgcttaa agggtagcca gttagggttc cggagaggag aaggaggaag 2958 aagaggagga ggagaaagaa gcagcaacga tcattctgcc attgtaaaga gtgactcttt 3018 ccttagggat ggtggtcttc tccccttgcc aggccttgga ctgcagcccc cagtcaaagg 3078 tctttgcagg acactttcta tccttggagt tgcagaggag gcctgattgg ccattccttc 3138 tgggacagac agagagaggg cccatggcct gctctgagct cccttcaatt tcaaggaacc 3198 cttagttctg agaggagaga ggaaggctgc acctaccgtg gcctcacagc tgggacccct 3258 catgggggcc aacccctggc ctgctgctgt gcttcagtga cacagtaaag cttaagaggg 3318 tggctgcctc ctaggaactc ctgggacttc taggtacaaa ctcaggtgcc cttataaaga 3378 gacccactgc ttgccttgag tccagaaagc actgcttctg cagtgaaaaa cacacactta 3438 ctatgtcagt tttggccata aaatgccagc caaatccact gctggcctga actgcccctg 3498 gacactggac tttctgcaca gtgactggca gcagagcaag tgcagccagg gtt tgtggcc 3558 aaagggaaga aagcatagta aattcaacct ctgttcctca tgggagtctg accgataatc 3618 tcaggcggac cttaggatct tgggcctgga ggcaagagaa aaaagctgga ggaagaggag 3678 tcgcagagaa acccagtcct ctgactggtt tctggtgagg tctctattca tcagtgggag 3738 ctgattttat ctgatttcct caagagtgca ttccagaagg ggacctgcta ttcttcgagg 3798 ggacctgcta ttcttcgagg ggacctgcta ttcttcgagg cagtggaccc tgtttgctga 3858 tggtcaacac tctggccctg ctgccccatg tccctgtgga gaagtgtgaa ggacgggtgc 3918 cttaaaccca cacttccagg gacccttcag cacaggtcct gcctgttccc atggtgcttc 3978 tcaccctgaa ccctcagagc tacagccagg gatagagcag atgagcagtg agctggtttc 4038 caccctctgg ggcaggaggg gcttgggctt ccctttgacc ctcttccttc ctttcccaga 4098 tcttcaatat ttgttgtgat gtaacagcca taagagctgt aagaggaact gtgggctttg 4158 ggagctttct tgggttgaaa gaggggtggg gggaggggat gcatgcaggg gtatgaaggc 4218 agcccaaggt ctcccagagg ctcgggagga aacccttttg gaatacatgt gttattgttg 4278 cattactgtg ttgtgaagat aagaagctgc tctgtatgct aaagctttct ctcctcaata 4338 aaaatataaa gggtgtgt 4356 <210> 17 <211> 3955 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3582) <400> 17 gca gga tta gaa tcg aat ctg aag aaa act gaa gac aga aaa agg aaa 48 Ala Gly Leu Glu Ser Asn Leu Lys Lys Thr Glu Asp Arg Lys Arg Lys 1 5 10 15 cta gag gag ctt ctt aat tct gtt ggt caa aag gta tca gaa ctc aaa 96 Leu Glu Glu Leu Leu Asn Ser Val Gly Gln Lys Val Ser Glu Leu Lys 20 25 30 gaa aaa ttt cag agc agg act tca gaa gct gcc aaa ctt gag gct gaa 144 Glu Lys Phe Gln Ser Arg Thr Ser Glu Ala Ala Lys Leu Glu Ala Glu 35 40 45 gta agc aag gca caa gaa aca atc aaa gct gca gaa gtc tta att aat 192 Val Ser Lys Ala Gln Glu Thr Ile Lys Ala Ala Glu Val Leu Ile Asn 50 55 60 cag ctt gac aga gaa cat aag aga tgg aat gca cag gtt gta gag ata 240 Gln Leu Asp Arg Glu His Lys Arg Trp Asn Ala Gln Val Val Glu Ile 65 70 75 80 aca gag gaa tta gct act ctt cct aaa aga gct caa ctt gct gct gca 288 Thr Glu Glu Leu Ala Thr Leu Pro Lys Arg Ala Gln Leu Ala Ala Ala 85 90 95 ttt att aca tat ctt tct gct gct cct gaa tct ctg aga aaa acc tgt 336 Phe Ile Thr Tyr Leu Ser Ala Ala Pro Glu Ser Leu Arg Lys Thr Cys 100 105 11 0 ttg gaa gaa tgg acc aag tca gct ggt ctt gag aaa ttt gat ctg agg 384 Leu Glu Glu Trp Thr Lys Ser Ala Gly Leu Glu Lys Phe Asp Leu Arg 115 120 125 aga ttt ctt tgt act gaa agt gag cag tta att tgg aaa agt gaa ggc 432 Arg Phe Leu Cys Thr Glu Ser Glu Gln Leu Ile Trp Lys Ser Glu Gly 130 135 140 cta cca tca gat gac ctt tcc ata gaa aat gct ctt gta ata tta cag 480 Leu Pro Ser Asp Asp Leu Ser Ile Glu Asn Ala Leu Val Ile Leu Gln 145 150 155 160 agt cga gtg tgc cca ttt ctt ata gat cct tct tcc caa gct aca gag 528 Ser Arg Val Cys Pro Phe Leu Ile Asp Pro Ser Ser Gln Ala Thr Glu 165 170 175 tgg tta aaa aca cat ttg aaa gac tca cgt tta gaa gtt atc aat cag 576 Trp Leu Lys Thr His Leu Lys Asp Ser Arg Leu Glu Val Ile Asn Gln 180 185 190 cag gat agt aac ttt atc aca gct ctt gaa tta gca gta cgt ttt ggg 624 Gln Asp Ser Asn Phe Ile Thr Ala Leu Glu Leu Ala Val Arg Phe Gly 195 200 205 aaa acc ctt att ata caa gag atg gat ggt gta gaa cct gtt ctt tat 672 Lys Thr Leu Ile Ile Gln Glu Met Asp Gly Val Glu Pro Val Leu Ty r 210 215 220 cca tta ttg aga cga gat ctg gtt gct caa gga cca cgt tat gtg gta 720 Pro Leu Leu Arg Arg Asp Leu Val Ala Gln Gly Pro Arg Tyr Val Val 225 230 235 240 caa ata ggt gac aaa att att gac tac aat gaa gaa ttc cgc ctc ttt 768 Gln Ile Gly Asp Lys Ile Ile Asp Tyr Asn Glu Glu Phe Arg Leu Phe 245 250 255 ttg tca aca aga aac cca aat cct ttt att cca ccg gat gca gct tcc 816 Leu Ser Thr Asn Pro Phe Ile Pro Pro Asp Ala Ala Ser 260 265 270 att gtt act gag gtt aac ttt act aca aca aga agt gga tta cga ggg 864 Ile Val Thr Glu Val Asn Phe Thr Thr Thr Arg Ser Gly Leu Arg Gly 275 280 285 cag ctt tta gct tta acc att cag cat gag aaa cct gat tta gaa gaa 912 Gln Leu Leu Ala Leu Thr Ile Gln His Glu Lys Pro Asp Leu Glu Glu 290 295 300 cag aaa aca aaa cta tta caa cag gaa gaa gat aag aaa ata cag cta 960 Gln Lys Thr Lys Leu Leu Gln Gln Glu Glu Asp Lys Lys Ile Gln Leu 305 310 315 320 gcc aag ctc gaa gaa tct ctt cta gag aca ctt gcc aca tct caa ggc 1008 Ala Lys Leu Glu Glu Ser Leu Leu Glu ThrAla Thr Ser Gln Gly 325 330 335 aat att ttg gaa aat aag gat ttg att gag tct ttg aat cag aca aaa 1056 Asn Ile Leu Glu Asn Lys Asp Leu Ile Glu Ser Leu Asn Gln Thr Lys 340 345 350 350 gca agc agt gcat at caa gag tca ctt aaa gaa tct tac aaa ctc 1104 Ala Ser Ser Ala Leu Ile Gln Glu Ser Leu Lys Glu Ser Tyr Lys Leu 355 360 365 caa att tcc ctt gat caa gaa cgg gat gcc tat ctc ccc ctg gct gag 1152 Gln Ile Leu Asp Gln Glu Arg Asp Ala Tyr Leu Pro Leu Ala Glu 370 375 380 agt gcc agc aag atg tac ttc att att tct gat ttg tcc aaa att aat 1200 Ser Ala Ser Lys Met Tyr Phe Ile Ile Ser Asp Leu Ser Lys Ile Asn 385 390 395 400 aac atg tac cgt ttt agt ttg gct gct ttt ctc cga ctt ttc caa cga 1248 Asn Met Tyr Arg Phe Ser Leu Ala Ala Phe Leu Arg Leu Phe Gln Arg 405 410 415 gct cta caa aac aaa cag gat tctcaa gaa cag aga atc cag 1296 Ala Leu Gln Asn Lys Gln Asp Ser Glu Asn Thr Glu Gln Arg Ile Gln 420 425 430 tca ctt atc agc tca tta caa cat atg gta tat gaa tat ata tgt cgt 1344 Ser Leu Ile Ser Ser Leu G ln His Met Val Tyr Glu Tyr Ile Cys Arg 435 440 445 tgt cta ttt aag gct gat cag ttg atg ttc gct ttg cat ttt gtt cga 1392 Cys Leu Phe Lys Ala Asp Gln Leu Met Phe Ala Leu His Phe Val Arg 450 455 460 460 gg atg cat cct gaa ctt ttt caa gaa aat gaa tgg gat acg ttt aca 1440 Gly Met His Pro Glu Leu Phe Gln Glu Asn Glu Trp Asp Thr Phe Thr 465 470 470 475 480 ggt gtg gtt gtt gga gac atg tta cgg aaa gct gac tca caa aaa 1488 Gly Val Val Val Gly Asp Met Leu Arg Lys Ala Asp Ser Gln Gln Lys 485 490 495 ata cgt gat cag ctt ccg tct tgg ata gat cag gaa cga agc tgg gcc 1536 Ile Arg Asp Gln Leu Pro Ser Trp Ile Asp Gln Glu Arg Ser Trp Ala 500 505 510 gtg gca aca tta aag att gct ctc ccc agt ctt tat cag acc ctc tgc 1584 Val Ala Thr Leu Lys Ile Ala Leu Pro Ser Leu Tyr Gln Thr Leu Cys 515 520 525 ttt gaa gat gca gct ct tgg cgt act tat tat aat aat tca atg tgt 1632 Phe Glu Asp Ala Ala Leu Trp Arg Thr Tyr Tyr Asn Asn Ser Met Cys 530 535 540 gag caa gag ttt cca tct atc ctt gca aag aaa gtt tcc tta ttt cag 1680 Glu Gl n Glu Phe Pro Ser Ile Leu Ala Lys Lys Val Ser Leu Phe Gln 545 550 555 560 cag att ctt gta gta cag gtg cta aga ccg gac aga ttg caa agt gcc 1728 Gln Ile Leu Val Val Gln Val Leu Arg Pro Asp Arg Leu Gln Ser Ala 565 570 575 atg gct ctt ttt gca tgt aaa act ctg gga ctg aaa gag gtg tcc cca 1776 Met Ala Leu Phe Ala Cys Lys Thr Leu Gly Leu Lys Glu Val Ser Pro 580 585 590 ctct cct cta aat ctc aaa cgt ttac aaa gag aca ctg gaa att gaa 1824 Leu Pro Leu Asn Leu Lys Arg Leu Tyr Lys Glu Thr Leu Glu Ile Glu 595 600 605 ccc atc ttg ata att att tct ccg ggt gct gat cct tct cag gaa ctt 1872 Pro Ile Leu Ile Ser Pro Gly Ala Asp Pro Ser Gln Glu Leu 610 615 620 caa gaa cta gct aat gct gaa aga agc gga gag tgt tat cac cag gtt 1920 Gln Glu Leu Ala Asn Ala Glu Arg Ser Gly Glu Cys Tyr His Gln Val 625 630 635 640 gcc atg ggt caa ggt caa gct gat tta gca att caa atg cta aaa gaa 1968 Ala Met Gly Gln Gly Gln Ala Asp Leu Ala Ile Gln Met Leu Lys Glu 645 650 650 655 tgt gcc cgc aat gga gac tgg ctc tgt ttg ag cat ctt gtg 2016 Cys Ala Arg Asn Gly Asp Trp Leu Cys Leu Lys Asn Leu His Leu Val 660 665 670 gta tct tgg ctg cca gtt ctg gaa aag gaa ttg aat act ctt caa cct 2064 Val Ser Trp Leu Pro Val Leu Glu Lys Glu Leu Asn Thr Leu Gln Pro 675 680 685 aaa gat acc ttt cgt ctt tgg ctc act gca gaa gtt cat ccc aac ttt 2112 Lys Asp Thr Phe Arg Leu Trp Leu Thr Ala Glu Val His Pro Asn Phe 690 695 700 act cct att tta cta cag tca agt ctg aag ata aca tat gag tca cct 2160 Thr Pro Ile Leu Leu Gln Ser Ser Leu Lys Ile Thr Tyr Glu Ser Pro 705 710 710 720 cca ggt tta aag aag aat tta atg cgt act tat gag tct tgg act cct 2208 Pro Gly Leu Lys Lys Asn Leu Met Arg Thr Tyr Glu Ser Trp Thr Pro 725 730 735 gag caa att agc aaa aaa gat aat aca cat cga gct cat gct ctc ttc 2256 Glu Gln Ile Ser Lys Lys Asp Asn Thr His Arg Ala His Ala Leu Phe 740 745 750 agt ctt gca tgg ttt cat gct gca tgt caa gaa aga aga aac tat att 2304 Ser Leu Ala Trp Phe His Ala Ala Cys Gln Glu Glu Arg Arg Asn Tyr Ile 755 760 765 cct cag ggt tgg aca aag ttt tat g aa ttt tct tta tca gat ctt cgg 2352 Pro Gln Gly Trp Thr Lys Phe Tyr Glu Phe Ser Leu Ser Asp Leu Arg 770 775 780 gct ggg tac aac att att gac aga ctt ttt gat ggt gcc aaa gat gta 2400 Ala Gly Tyr Asn Ile Ile Asp Arg Leu Phe Asp Gly Ala Lys Asp Val 785 790 795 800 caa tgg gaa ttt gta cat ggt tta ctt gaa aat gct att tat gga gga 2448 Gln Trp Glu Phe Val His Gly Leu Leu Glu Asn Ala Ile Tyr Gly Gly 805 810 815 cgt ata gac aac tat ttt gac ctt aga gtt ctt cag tca tac ctg aag 2496 Arg Ile Asp Asn Tyr Phe Asp Leu Arg Val Leu Gln Ser Tyr Leu Lys 820 825 830 cag ttt ttt aat tct tca gtt att gat gta ttcac agg aac aag 2544 Gln Phe Phe Asn Ser Ser Val Ile Asp Val Phe Asn Gln Arg Asn Lys 835 840 845 aaa agc att ttt cca tat tcc gta tct cta cca caa tcc tgc agc att 2592 Lys Ser Ile Phe Pro Tyr Ser Val Ser Leu Pro Gln Ser Cys Ser Ile 850 855 860 ttg gac tat cgt gct gtc att gag aaa att cca gag gac gac aaa cct 2640 Leu Asp Tyr Arg Ala Val Ile Glu Lys Ile Pro Glu Asp Asp Lys Pro 865 870 875 880 880 agt ttc t tt ggt ctg cct gcc aat atc gct cgc tca tct cag cgc atg 2688 Ser Phe Phe Gly Leu Pro Ala Asn Ile Ala Arg Ser Ser Gln Arg Met 885 890 895 atc agt tct cag gtt att tca cag ttg agg att ttg ccc aga 2736 Ile Ser Ser Gln Val Ile Ser Gln Leu Arg Ile Leu Gly Arg Ser Ile 900 905 910 aca gct ggt tcc aaa ttt gat aga gaa atc tgg tct aat gaa ctt tct 2784 Thr Ala Gly Ser Lys Phe Asp Arg Glu Ile Trp Ser Asn Glu Leu Ser 915 920 925 cct gtc ctc aat ctc tgg aag aaa cta aac cag aat tca aac cta ata 2832 Pro Val Leu Asn Leu Trp Lys Lys Leu Asn Gln Asn Ser Asn Leu Ile 930 935 940 cat cag aaa gtg cct cct cct gat cga caa gga tct cca ata ctg 2880 His Gln Lys Val Pro Pro Pro Asn Asp Arg Gln Gly Ser Pro Ile Leu 945 950 955 960 tca ttc atc att ctt gaa caa ttt aat gct att cgt tta gta caa agt 2928 Ser Phe Ile Ile Leu Glu Gln Phe Asn Ala Ile Arg Leu Val Gln Ser 965 970 975 gtc cac cag tct ctt gct gct ctc agc aaa gtc atc aga gga act act 2976 Val His Gln Ser Leu Ala Ala Leu Ser Lys Val Ile Arg Gly Thr Thr 98 0 985 990 tta ctg agt tca gaa gta caa aaa ttg gca agt gct tta tta aac caa 3024 Leu Leu Ser Ser Glu Val Gln Lys Leu Ala Ser Ala Leu Leu Asn Gln 995 1000 1005 aag tgt cct ctc gca tgg cag agc aag tgg ggc cca gaa gat ccc 3072 Lys Cys Pro Leu Ala Trp Gln Ser Lys Trp Glu Gly Pro Glu Asp Pro 1010 1015 1020 tta caa tac ctg aga ggt ctt gtt gcc cgt gcc ctt gca ata cag aac 3120 Leu Gln Tyr Leu Arg Gly Leu Val Ala Arg Ala Leu Ala Ile Gln Asn 1025 1030 1035 1040 tgg gta gat aaa gct gaa aaa cag gct ctt ctc tct gaa aca ctt gac 3168 Trp Val Asp Lys Ala Glu Lys Gln Ala Leu Leu Ser Glu Thr Leu Asp 1045 10ca 1055 c gaa ctt ttc cat cca gac aca ttt ctt aat gct ctt cgc cag 3216 Leu Ser Glu Leu Phe His Pro Asp Thr Phe Leu Asn Ala Leu Arg Gln 1060 1065 1070 gaa act gca agg gca gtg ggt cgt tct gtg gat agc cttaaa 3264 Glu Thr Ala Arg Ala Val Gly Arg Ser Val Asp Ser Leu Lys Phe Val 1075 1080 1085 gcc tca tgg aaa ggt cga ctg caa gaa gca aag cta caa att aag atc 3312 Ala Ser Trp Lys Gly Arg Leu Gln Glu Ala Lys Leu Gln Ile Lys Ile 1090 1095 1100 agt ggc ttg tta cta gaa gga tgt agt ttt gat gga aat caa ctt tct 3360 Ser Gly Leu Leu Leu Glu Gly Cys Ser Phe Asp Gly Asn Gln Leu Ser 1105 1110a 1120 aat cag ctt gat tct ccc agc gtg tca tca gtg ctc cct tgt ttt 3408 Glu Asn Gln Leu Asp Ser Pro Ser Val Ser Ser Val Leu Pro Cys Phe 1125 1130 1135 atg ggc tgg att cca cag gat gca tgt ggt cca tat tct ccg at gag 3456 Met Gly Trp Ile Pro Gln Asp Ala Cys Gly Pro Tyr Ser Pro Asp Glu 1140 1145 1150 tgc atc tct ttg cct gtt tac aca agt gct gaa agg gat cgt gtg gtt 3504 Cys Ile Ser Leu Pro Val Tyr Thr Ser Ala Glu Arg Asp Arg Val Val 1155 1160 1165 acc aat att gat gtt cca tgt ggg ggc aac caa gac cag tgg att cag 3552 Thr Asn Ile Asp Val Pro Cys Gly Gly Asn Gln Asp Gln Trp Ile Gln 1170 1175 1180 tgt gga gca gct cta ttc cta aaa aat cag tagaatctaa tgacaacaaa 3602 Cys Gly Ala Ala Leu Phe Leu Lys Asn Gln 1185 1190 agccatcttc acaaaaggga acattgattc tttaagcttt aaatcaaaca tgtggtcagt 3662 ctacatttga aatgt tagtt caaaatatta acatatagtt atgttgttga tgtcactgaa 3722 attttaatgt gtaaaagcag cactgtgcat cttttaaagt aataaattaa tggagttatt 3782 gttaaaacag agtattcttt tgacaacatt aaatatttct gtgagaaagt tcacttttcc 3842 agtggctcaa aaatttgttt taggtcagag attttaagtg gtatattaac caataataaa 3902 tattttggct gtcatttgtg tcataattat ttaataaaag agcattcata att 3955 <210> 18 <211> 6004 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1081) .. (5760) <400> 18 gcgccttgga gttctcgctt ccactcacct ccagaggacg atgcccctca ccccacaccc 60 acgttcatcc aagcatggtc tctgctccct tttctggtcc tgggctgggc agcctgggcc 120 gggagtgctc ctggcttctc tgggatggct ggagcccacc acaagcccca gccctggccc 180 gtgctgtcct cctgctggga ggagttgctt agtgcagcag acagagcaga ggctctgagt 240 ggtcctgcca ctcactagct gtgtggcctt gggcaagtgg atgaaccttt ctgaggtcca 300 gcgttcccgt ctgtaaaaca gaattcccag caggacctac cttgtgagtt tcagaggctt 360 aacggagata gtccatgaga gagctgtgtg ctccagggca gccgttctgt cccactctgg 420 ccggtcctgc ctttggcatg gcctgtcctc cgtggccttg tagagacgca ggagtctcaa 480 aggcagtgga agacagaggc cccagggtgg gcccgcctgt agccccactt cccccacgtc 540 aggaggaaag ggaagaggga gagtccccca gtctctctca gttggcagag gctctgcacc 600 cctttacaga ggatcctgcc gcctcaggac agccaggagg gggctggagg gagaggaggt 660 ggcccctgcc ctcagtccct ggacgggcac tattcatggc cccctgttct gtcccacaat 720 ccagtgtgtc cttgtgaccg tgccctccct gaggctggtg gtgatggtgg cctgtgtgtg 780 catccaagct cctgtgtgtg tgtttcaagg ggcacaaagc tgcatgaagc ttcctaagag 840 agtgctgagg g agcacttcc tataggagga aggctggaag gcttcctgga ggcagcagcc 900 tggagccctg tgcatgagga tgcgggactc tgatagccaa cctgctattt agtagggaaa 960 gtcgccttcc aagccacagg atggccgtga caagaggccc aaaggctcgc aggagtgctg 1020 cagcagaggg caggggtgtg ggcagctaga gggacctgtg gctgggcagg gctgaggtag 1080 ccc gtg tgc tgt gcc gga tcc ttt aga ctt gac cct gtt ggc tac aca 1128 Pro Val Cys Cys Ala Gly Ser Phe Arg Leu Asp Pro Val Gly Tyr Thr 1 5 10 15 gca tca gcc ctg ggt att act cat ccc tgc gcc ctg gcc aga atg aag 1176 Ala Ser Ala Leu Gly Ile Thr His Pro Cys Ala Leu Ala Arg Met Lys 20 25 30 gaa gcc tct ggg gtg ggg gga ggg cac agc ccc atg tgc cca cct cac 1224 Glu Ala Ser Gly Val Gly Gly Gly His Ser Pro Met Cys Pro Pro His 35 40 45 tgc cac atg ccc cca ggc cct gcg ggt gaa tgg cct gga gca act gtg 1272 Cys His Met Pro Pro Gly Pro Ala Gly Glu Trp Pro Gly Ala Thr Val 50 55 60 caa caa cct cgc cag cga gcg cct aca gct ctt ctc cag cca gat gct 1320 Gln Gln Pro Arg Gln Arg Ala Pro Thr Ala Leu Leu Gln Pro Asp Ala 65 70 75 80 gct ggc cca gga gga gga gga gtg tcg gcg gga gtt gct gtc ctg ggt 1368 Ala Gly Pro Gly Gly Gly Gly Val Ser Ala Gly Val Ala Val Leu Gly 85 90 95 gcc tgt ccc tca gcc tcc gag gga gtc ctg cct aga cct cct ggt aga 1416 Cys Pro Ser Ala Ser Glu Gly Val Leu Pro Arg Pro Pro Gly Arg 100 105 110 tca gcc cca cag cct cct gag tat cct gga cgc cca gac atg gct gtc 1464 Ser Ala Pro Gln Pro Pro Glu Tyr Pro Gly Arg Pro Asp Met Ala Val 115 120 125 cca ggc tgg agt gca atg gtg cgg tct cgg ctc act gca acc tcc acc 1512 Pro Gly Trp Ser Ala Met Val Arg Ser Arg Leu Thr Ala Thr Ser Thr 130 135 140 tcc cag gcc acg gac cac acc ttc ctc cag aag agc cac tat cac cat 1560 Ser Gln Ala Thr Asp His Thr Phe Leu Gln Lys Ser His Tyr His His 145 150 155 160 ggt gac cac ccc agc tat gcc aag ccc cgg ctg ccc ctg ccc gtg ttc 1608 Gly Asp His Pro Ser Tyr Ala Lys Pro Arg Leu Pro Leu Pro Val Phe 165 170 175 acc gtg cga cat tat gca ggg act gtc acc tac cag gtt cac aag ttt 1656 Thr Val Arg His Tyr Ala Gly Thr Val Thr Tyr Gln Val His Lys Phe 180 185 190 tta aac aga aac cgg gat cag ctg gac cct gct gtg gtg gag atg ctt 1704 Leu Asn Arg Asn Arg Asp Gln Leu Asp Pro Ala Val Val Glu Met Leu 195 200 205 ggc cag agc cag ctc cag ctg gtg gc gc gc gc gc gc gc gc gc gc gg gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gca gag 1752 Gly Gln Ser Gln Leu Gln Leu Val Gly Ser Leu Phe Gln Glu Ala Glu 210 215 220 ccc cag tcc agg gga ggg cga ggc aga ccc acg ctg gcc tct cgc ttc 1800 Pro Gln Ser Arg Gly Gly Arg Gly Arg Pro Thr Leu Ala Ser Arg Phe 225 230 235 240 cag cag gcc ctg gag gac ctc ata gcc cgg ctg ggc agg agc cat gtc 1848 Gln Gln Ala Leu Glu Asp Leu Ile Ala Arg Leu Gly Arg Ser His Val 245 250 255 tat ttc atc cag ctc acc cct aac cct gga aag ctt cca ggc ctc 1896 Tyr Phe Ile Gln Cys Leu Thr Pro Asn Pro Gly Lys Leu Pro Gly Leu 260 265 270 ttt gac gtg gga cat gtg aca gag caa ctg cac cag gca gcc ata Aspg 1944 Val Gly His Val Thr Glu Gln Leu His Gln Ala Ala Ile Leu 275 280 285 gag gcc gtg ggc acc cgc agt gcc aac ttc ccc gtg cgt gtg ccc ttt 1992 Glu Ala Val Gly Thr Arg Ser Ala Asn Phe Pro Val Arg Val Pro Phe 290 295 300 gag gcc ttc ctg gcc agc ttc cag gcc ctg ggg tca gaa ggg cag gaa 2040 Glu Ala Phe Leu Ala Ser Phe Gln Ala Leu Gly Ser Glu Gly Gln Glu 305 310 315 320 gac ctc tct gag cgg ggg ggt gcc gtc ctg agc cag gtg ctg 2088 Asp Leu Ser Asp Arg Glu Lys Cys Gly Ala Val Leu Ser Gln Val Leu 325 330 335 ggg gcc gaa tca cct ctc tat cac ctt gga gcc acc aag gtc ctg ctg 2lu Gly Leu Tyr His Leu Gly Ala Thr Lys Val Leu Leu 340 345 350 cag gag cag ggc tgg cag cgg ctg gag gag ctc cgg gac cag cag cgc 2184 Gln Glu Gln Gly Trp Gln Arg Leu Glu Glu Leu Arg Asp Gln Gln Arg 355 360 tcc cag gcc ctg gtc gac ctg cac cgc agc ttc cac acc tgc atc tcc 2232 Ser Gln Ala Leu Val Asp Leu His Arg Ser Phe His Thr Cys Ile Ser 370 375 380 cgc cag cgc gtc ctg ccc cgg atg atg ggt cg ttc cag 2280 Arg Gln Arg Val Leu Pro Arg Met Gln Ala Arg Met Arg Gly Phe Gln 385 390 395 400 gcc agg aag cgg tac ctc cgg cgg cgg gca gct ttg gga cag ctg aac 2328 Ala Arg Lys Arg Tyr Leu Arg Ag rg Ala Ala Leu Gly Gln Leu Asn 405 410 415 acc atc ctg ctg gtg gcc cag ccc ctg ctc cag agg cgg cag aga ctg 2376 Thr Ile Leu Leu Val Ala Gln Pro Leu Leu Gln Arg Arg Gln Arg Leu 420 425 430 gag c cgt tgg cag ggc tgg cat agc agc gaa agg gcc ttg gag 2424 Gln Leu Gly Arg Trp Gln Gly Trp His Ser Ser Glu Arg Ala Leu Glu 435 440 445 aga gtg cca agc atg gag ctg ggg cgc ttg gag atc cc Arg Val Pro Ser Met Glu Leu Gly Arg Leu Glu Ile Pro Ala Glu Leu 450 455 460 gcc gtc atg ctg aag acg gcg gaa agc cat cgg gac gcc ctg gct ggg 2520 Ala Val Met Leu Lys Thr Ala Glu Ser His Arg Asp Ala Leu Ala Gly 465 470 475 480 agc atc acc gag tgc ctg ccg cct gag gtt cct gcc cgg ccc agc ctg 2568 Ser Ile Thr Glu Cys Leu Pro Pro Glu Val Pro Ala Arg Pro Ser Leu 485 490 495 act ctc cca gca gac att gacg ttc cct ttc tcc agc ttc gtc gcc 2616 Thr Leu Pro Ala Asp Ile Asp Leu Phe Pro Phe Ser Ser Phe Val Ala 500 505 510 atc ggc ttt cag gaa ccg tcc ctg ccc agg cca ggg cag cca ctg gcg P26 Gle Gly ln Glu Pro Ser Leu Pro Arg Pro Gly Gln Pro Leu Ala 515 520 525 aag ccc cta acc cag ctg gat gga gac aac cct cag cgt gcc ctg gac 2712 Lys Pro Leu Thr Gln Leu Asp Gly Asp Asn Pro Gln Arg Ala Leu Asp 530 535 540 atc aac aaa gtg atg ctg cgg ctc ctg ggg gac gga tcc ctg gag tcc 2760 Ile Asn Lys Val Met Leu Arg Leu Leu Gly Asp Gly Ser Leu Glu Ser 545 550 555 560 tgg cag agg cag atc atg ggc gca t cgg cag ggg cag tgc 2808 Trp Gln Arg Gln Ile Met Gly Ala Tyr Leu Val Arg Gln Gly Gln Cys 565 570 575 tgg cca ggg ctg cgg aat gag ctc ttt agc cag ctg gtg gcc cag cta 2856 Trp Pro Gly Leu Arg Phe Ser Gln Leu Val Ala Gln Leu 580 585 590 tgg cag aac cca gat gaa cag cag agc cag cgt ggc tgg gcc ctc atg 2904 Trp Gln Asn Pro Asp Glu Gln Gln Ser Gln Arg Gly Trp Ala Leu Met 595 600 605 gct gtt ctc agc gcc ttt ccc cca ctg cct gtc cta cag aag cca 2952 Ala Val Leu Leu Ser Ala Phe Pro Pro Leu Pro Val Leu Gln Lys Pro 610 615 620 ctg ctc aag ttc gtg tct gac cag gcc ccc agg ggc atg gg gcg 3000 Leu Leu Lys Phe Val Ser Asp Gln Ala Pro Arg Gly Met Ala Ala Leu 625 630 635 640 tgc cag cac aag ctg ctg ggg gcc ttg gag cag tcg cag ctg gcc tcg 3048 Cys Gln His Lys Leu Leu Gly Ala Leu Glu Gln Leu Ala Ser 645 650 655 ggg gcc act cgg gcc cac ccc ccg acc cag ctg gag tgg ctg gcc gga 3096 Gly Ala Thr Arg Ala His Pro Pro Thr Gln Leu Glu Trp Leu Ala Gly 660 665 670 tgg cgg cgg ggc cgc atgg ctg gat gtg ttc acc ttc agc gag gag 3144 Trp Arg Arg Gly Arg Met Ala Leu Asp Val Phe Thr Phe Ser Glu Glu 675 680 685 tgc tac tcg gcc gag gtg gag tct tgg acc acc ggg gag cag ctg Gyr 3192 Cys Glu Val Glu Ser Trp Thr Gly Glu Gln Leu Ala 690 695 700 ggg tgg atc ctg cag agc aga ggc ctg gag gcg cct ccc cgg ggc tgg 3240 Gly Trp Ile Leu Gln Ser Arg Gly Leu Glu Ala Pro Pro Arg Gly Trp 705 715 720 tct gtg tca ctg cac tcc agg gac gca tgg cag gac ttg gct ggc tgc 3288 Ser Val Ser Leu His Ser Arg Asp Ala Trp Gln Asp Leu Ala Gly Cys 725 730 735 gac ttt gtg ctg gac ctg atc agc act gag gac ctg ggg gac cca 3336 Asp Phe Val Leu Asp Leu Ile Ser Gln Thr Glu Asp Leu Gly Asp Pro 740 745 750 gct cgc ccc cgc agc tac ccc atc act cct ctt ggc tca gcc gag gcc 3384 Ala Arg Pro Arg Ser Tyr Pro Ile Thr Pro Leu Gly Ser Ala Glu Ala 755 760 765 att ccc ctt gcc cct ggc att cag gcc ccc tca ctg ccc cca gga ccc 3432 Ile Pro Leu Ala Pro Gly Ile Gln Ala Pro Ser Leu Pro Pro Gly Pro 770 775 780 780 cct cca ggt cca gcc cca acg ctg ccc agc agg gac cac aca ggg gag 3480 Pro Pro Gly Pro Ala Pro Thr Leu Pro Ser Arg Asp His Thr Gly Glu 785 790 795 800 gtc cag agg tca ggg agc ctg gac ggc ttc ctg gac cag atc cag 3528 Val Gln Arg Ser Gly Ser Leu Asp Gly Phe Leu Asp Gly Ile Phe Gln 805 810 815 cca gtg ata tcc tcc ggc ctc agc gat ctg gaa caa agc tgg gct ctg 3576 Pro Val Ile Ser Ser Gly Leu G Asp Leu Glu Ser Trp Ala Leu 820 825 830 agc agc cgc atg aag gga ggg ggc gcc att ggg ccc aca cag cag ggc 3624 Ser Ser Arg Met Lys Gly Gly Gly Ala Ile Gly Pro Thr Gln Gln Gly 835 840 845 tac ccc atg gtg tac cca gga atg att cag atg cct gca tac cag cca 3672 Tyr Pro Met Val Tyr Pro Gly Met Ile Gln Met Pro Ala Tyr Gln Pro 850 855 860 ggc atg gtc cct gca ccc atg ccc atg atg cca gca atg ggc aca gtc 3720 Gly Val Pro Ala Pro Met Pro Met Met Pro Ala Met Gly Thr Val 865 870 875 880 cct gcc atg cca gcc atg gtg gtg ccg ccg cag cca ccg ctt ccc agc 3768 Pro Ala Met Pro Ala Met Val Val Pro Pro Gln Pro Pro Leu Pro Ser 885 890 895 ctg gat gca ggg cag ctg gcc gtc cag cag cag aac ttt atc cag cag 3816 Leu Asp Ala Gly Gln Leu Ala Val Gln Gln Gln Asn Phe Ile Gln Gln 900 905 910 cag gcg cta atc ctg gcc cag cag gcc cag gcc atg tcc ctg 3864 Gln Ala Leu Ile Leu Ala Gln Gln Met Thr Ala Gln Ala Met Ser Leu 915 920 925 tcc ctg gag cag cag atg cag cag cgg cag cag cag gct cgg gcc tcc 3912 Ser Leu Glu Gln Gln Mln Gln Arg Gln Gln Gln Ala Arg Ala Ser 930 935 940 gag gct gcg tcc cag gcc tca ccc tca gcc gtc acc tcc aag ccc agg 3960 Glu Ala Ala Ser Gln Ala Ser Pro Ser Ala Val Thr Ser Lys Pro Arg 945 950 955 9 60 aag ccc ccc aca ccc ccg gag aag cca cag cgt gac ctg gga tca gag 4008 Lys Pro Pro Thr Pro Pro Glu Lys Pro Gln Arg Asp Leu Gly Ser Glu 965 970 975 ggt ggc tgc ctg agg gag acc tcc gag gag gct gaga gac agg ccc tat 4056 Gly Gly Cys Leu Arg Glu Thr Ser Glu Glu Ala Glu Asp Arg Pro Tyr 980 985 990 cag ccc aag agc ttc cag cag aaa cgg aac tat ttc cag agg atg ggg 4104 Gln Pro Lys Ser Phe Gln Gln Lys Arg Asg Tyr Phe Gln Arg Met Gly 995 1000 1005 cag cca cag atc aca gtg agg acg atg aag ccc ccg gcc aag gtc cac 4152 Gln Pro Gln Ile Thr Val Arg Thr Met Lys Pro Pro Ala Lys Val His 1010 1015 1020 atc ccc cag ggg gaa gcg cag gag gag gag gag gag gag gag gag gag 4200 Ile Pro Gln Gly Glu Ala Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu 1025 1030 1035 1040 gag gag cag gag gag caa gaa gtg gaa aca aga gca gtg ccg Glu Gln Glu Glu Gln Glu Val Glu Thr Arg Ala Val Pro Ser Pro 1045 1050 1055 cct cct ccc ccc atc gtg aag aag cca ttg aag caa ggt ggg gcc aaa 4296 Pro Pro Pro Pro Ile Val Lys Lys Pro Leu Ly s Gln Gly Gly Ala Lys 1060 1065 1070 gct cca aaa gag gct gag gct gag cca gcc aag gag aca gcg gcc aag 4344 Ala Pro Lys Glu Ala Glu Ala Glu Pro Ala Lys Glu Thr Ala Ala Lys 1075 1080 1085 ggc cat ggc cag cca gcc caa ggc agg ggg act gtg gtg cgc agc 4392 Gly His Gly Gln Gly Pro Ala Gln Gly Arg Gly Thr Val Val Arg Ser 1090 1095 1100 tca gac tcc aag ccc aag cgg cca caa ccc agc agg gaa att ggc aac 4440 Ser Lys Pro Lys Arg Pro Gln Pro Ser Arg Glu Ile Gly Asn 1105 1110 1115 1120 atc atc cgc atg tac cag agc cgc ccg ggc ccc gtg cct gtg ccc gtg 4488 Ile Ile Arle Met Tyr Gln Ser Arg Pro Gly Pro Val Pro Val Pro Val 1125 1130 1135 cag cca tcc agg cct ccc aaa gct ttc ctg agg aaa atc gac ccc aag 4536 Gln Pro Ser Arg Pro Pro Lys Ala Phe Leu Arg Lys Ile Asp Pro Lys 1140 1145 1150 gac gag gct ctg gcc aag ctg ggt at aac ggt gcc cac tcg tcc ccg 4584 Asp Glu Ala Leu Ala Lys Leu Gly Ile Asn Gly Ala His Ser Ser Pro 1155 1160 1165 ccg atg ctg tcc ccc agc cca gga aag ggc ccc ccg cca gct gtg gct 4632 P ro Met Leu Ser Pro Ser Pro Gly Lys Gly Pro Pro Pro Ala Val Ala 1170 1175 1180 cct cga ccc aag gcc ccg cta cag ctt ggg ccc tct agc tcc atc aag 4680 Pro Arg Pro Lys Ala Pro Leu Gln Leu Gly Pro Ser Ser Ser Ile Lys 1185 1190 1195 1200 gaa aag cag ggg ccc ctt ctg gac ctg ttt ggc cag aag ctg cct att 4728 Glu Lys Gln Gly Pro Leu Leu Asp Leu Phe Gly Gln Lys Leu Pro Ile 1205 1210 1215 gcc cac cca cccac gcg cca cca ctg cct ctg ccc gag 4776 Ala His Thr Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Leu Pro Glu 1220 1225 1230 gac cca ggg acc ctt tca gca gag cgt cgt tgc ttg aca cag ccc gtg 4824 Asp Pro Gly Thr Leu Ser Ala Glu Arg Arg Cys Leu Thr Gln Pro Val 1235 1240 1245 gag gac cag ggg gtc tcc acc cag cta ctc gcg ccc tct ggc agc gtg 4872 Glu Asp Gln Gly Val Ser Thr Gln Leu Leu Ala Pro Ser Gly Ser Val 1250 1255 1260 tgc ttc tcc tac acc ggc acg ccc tgg aag ttg ttc cta cgc aag gag 4920 Cys Phe Ser Tyr Thr Gly Thr Pro Trp Lys Leu Phe Leu Arg Lys Glu 1265 1270 1275 1280 gtg ttc tac cca cgg gag aac ttc agc cat ccc tac tac ctg agg ctc 4968 Val Phe Tyr Pro Arg Glu Asn Phe Ser His Pro Tyr Tyr Leu Arg Leu 1285 1290 1295 ctc tgt gag cag atc cta cgg gac acc ttc tcc gag tcc tgt atc cgg 5016 Leu Cys Gln Ile Leu Arg Asp Thr Phe Ser Glu Ser Cys Ile Arg 1300 1305 1310 att tcc cag aat gag cgg cgg aaa atg aaa gac ctg ctg gga ggc ttg 5064 Ile Ser Gln Asn Glu Arg Arg Lys Met Lys Asp Leu Leu Gly Le 1320 1325 gag gtg gac ctg gat tct ctc acc acc acc gaa gac agc gtc aag aag 5112 Glu Val Asp Leu Asp Ser Leu Thr Thr Thr Glu Asp Ser Val Lys Lys 1330 1335 1340 cgc atc gtg gtg gcc gct cgg gac aat tgg gcc tac ttc tcc cgc 5160 Arg Ile Val Val Ala Ala Arg Asp Asn Trp Ala Asn Tyr Phe Ser Arg 1345 1350 1355 1360 ttc ttt cct gtc tcg ggc gag agt ggc agc gac gtg cag ctg tta gcc 5208 Phe Ghe Ser Val Gly Ser Asp Val Gln Leu Leu Ala 1365 1370 1375 gtg tcc cac cgt ggg ctg cga ctg ctc aag gtg acc caa ggc ccc ggc 5256 Val Ser His Arg Gly Leu Arg Leu Leu Lys Val Thr Gln Gly Pro G ly 1380 1385 1390 ctc cgc ccc gac cag ctg aag att ctc tgc tca tac agc ttt gcg gag 5304 Leu Arg Pro Asp Gln Leu Lys Ile Leu Cys Ser Tyr Ser Phe Ala Glu 1395 1400 1405 gtg ctg ggt cgg ggg tgg acc ctg gag ctg tca ctg 5352 Val Leu Gly Val Glu Cys Arg Gly Gly Ser Thr Leu Glu Leu Ser Leu 1410 1415 1420 aag agc gag cag ctg gtg ctg cac aca gcc cgg gca agg gcc atc gag 5400 Lys Ser Glu Gln Leu Val His Thr Ala Arg Ala Arg Ala Ile Glu 1425 1430 1435 1440 gcg ctg gtt gag cta ttc ctg aat gag ctt aag aag gac tcc ggc tat 5448 Ala Leu Val Glu Leu Phe Leu Asn Glu Leu Lys Lys Asp Ser Gly Tyr 1445 1450 atc gcc ctg cgc agc tac atc act gac aac tgc agc ctc ctc agc 5496 Val Ile Ala Leu Arg Ser Tyr Ile Thr Asp Asn Cys Ser Leu Leu Ser 1460 1465 1470 ttc cac cgt ggg gac ctc atc ag ctg ctg ccg gcc cc gag 5544 Phe His Arg Gly Asp Leu Ile Lys Leu Leu Pro Val Ala Thr Leu Glu 1475 1480 1485 cca ggc tgg cag ttt ggc tct gcc ggg ggc cgt tcc gga ctc ttt cct 5592 Pro Gly Trp Gln Phe Gly Ser Ala Gly Gly Arg Ser Gly Leu Phe Pro 1490 1495 1500 gcc gac ata gtg cag ccg gct gcc gct ccc gac ttt tcc ttc tcc aag 5640 Ala Asp Ile Val Gln Pro Ala Ala Ala Pro Asp Phe Ser Phe Ser Lys 1505 1510 1515 1520 gag cag agg agt ggc tgg cac aag ggt cag ctg tcc aac ggg gaa cca 5688 Glu Gln Arg Ser Gly Trp His Lys Gly Gln Leu Ser Asn Gly Glu Pro 1525 1530 1535 ggg ctg gct cgg tgg gac agg gcc tca gag gtg atg gga gag 5736 Gly Leu Ala Arg Trp Asp Arg Ala Ser Glu Val Arg Lys Met Gly Glu 1540 1545 1550 gga caa gca gag gca agg cct gcc tgagactgag gaaggaaagg ggtttgacca 5790 Gly Gln Ala Glu Ala gg tgcctgcctgcctgcctgcc ctgcccctct 5850 gcccgctcct gatggctcgc cttgtctctc cagcaagact gtgcactcct tgcaggcagg 5910 ggctgggctg gatgctgctc ttgtgtccca cgtggtactt agttcaaggc tgccccagca 5970 gatgcctatcact ag <210> 19 <211> 5954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4238) .. (5953) <400> 19 gcggccgccc tctaccctca atccccactg gagattcctc accccgggac cgtccgcgcg 60 ggcgtggtcg ggctccgcgc ctcgcgcagc ggggtggcac aggcggccag ggagggccca 120 cgcacccggc gcgagctaga agcctccggt cggcctgcag tgcccaagtc ccatggcgag 180 ggcagcccga gtggccgtcg cggctgtagg tccgcatgcc gggcaccgca ccaggcgtct 240 agcaggtagg ggcagggaag gtagggctgc gctggcggcc ggtgcccagt taccggcgat 300 cggggacgct cggagacacc tggtctcccg gaagcgccct tcggaaatgg gattcgaccc 360 ggcttgcggg cggcgggtgt ttagaagaag aggctgcggg caagcagtgc cccctctctg 420 gttccccgga ctcctcttag ccccctcgtg gcctgatggg cggccgggac ggaggtgggc 480 tgtaagcccg ccggcaccca ccgtgtcctg tggaaggctt ggagacctga gccaggctct 540 actcggttag atgcgagtga gacaggcgac ggagttcgtc tttaagcctc ccttgcctca 600 gcaaggagag ggagcgtttt ccttatttta atgaccgcct ttccctccct tggggtccca 660 gttcaccctg aacctttcca cagccttaaa agcccgctct ccctagcgga gtgctgcggc 720 agttcttcag aagacacggg gccaaatgaa acttacttaa agtggttatc gcgtttcagg 780 ctgatttgtt cctagtaact acgttttgga aagcagctgt ggactctcaa ggacaggcag 840 gaacgaagac c tccttaggg tccgagtgtc gcttcccaca gttagattac ccatgaattt 900 ccttgattct gtaggtctca agaatctcat gagcccccaa ccacctccac ctttctctct 960 gaatctctct cctgtctctg aaattcttcg caaaaataat ctgtcctcaa ggaatattga 1020 aagcgtcatc aatgtcttga aggaaattac tgtatctgag aaccgaaact agtatttgat 1080 gtttcacttt caaatacatt tttttttaat aaaaaggata cctttaagta aaacactacc 1140 actgctattt acgtttaagt agatttttaa ttcatattaa gcagtagtgt gctttttgga 1200 aagatgatgg actgggactc ataatccctg ggttttgttt ctatttgtag tttcttgagt 1260 aagtcagcac tttccctggt taagaaatga cctcatctgt aaaatgaacc tgacttctaa 1320 ggtcttgttc ggctctcacg tctttacttc agttaaatat tgacataata catgtttgtt 1380 gaatgaatga ctgaatgaat aaatcttatt gctctaggaa ctatgtgctt ttaacctttg 1440 gaaatacata gaaacaaatg cctcctttgc taggaaaggg agcttaattg tgctcccact 1500 gcatcagact gcttccatct aatgatgcaa ttgcaataca gggtgggagg ccatccacag 1560 ggctgtccct ctgcctcaga gctcatctca agtttgccct tctctatgga gaaggaaaat 1620 ttgagtctcc agaaggaaag tattttgcta aacgccaagc aagaattaga gggtaagggg 1680 gcttctgatg cctggtcca a ggctcttaga agaagaagaa ggagaaaggg agaaagctca 1740 agaaaataat gcacagatca ccagctacag gtggccctag tgcctaagtt tataaactac 1800 ccccgccctt cccggagaga aaggagcttg tataaaggga acaatcctag aacctaggct 1860 taacaaggaa ggagaagggg agaagcaagg gtcattctgt tctcaagtgg tttgttgtat 1920 ctgtgtgttt atctattcca catttggcca ggcagtggga ctccgggaaa gcaagctgaa 1980 gtgttttgtg ggacaggcac atcatttggt caactccttt tccctggttg attccctcct 2040 tttcctgacc catctccccc ttcctaccag aggcaaccaa ggcctttcca ggcaacagca 2100 gacattattt accccttgcg aattgattcc acaatggaag actcttgggt ccaaggagct 2160 gtaagataat taaggagaaa acagataatg aaggcaaaaa tccaacacct ggccattagc 2220 aatgctctgg aaaggctatt taaacccgca ttggatatca gagctgggag ggcccataca 2280 gtctacctac ctgccttttg cagatggaca caggaagatc cagaagctag tggcacatct 2340 agcaacagag ccagatcaga acccaggtaa gctcggtctc aggccaggat tccttttcca 2400 tctcctctct ttctcaggag ccagtcttcc tgcaccagct tcctcttttc tcctagctcc 2460 cctgcccctg cagcctggag ggctcaacca cccttccttt ggctcccact cccagctgag 2520 gctcagcctg gcagtgcttt tct gacaccc acttcttttc tccttcctcc aggcaagaag 2580 tgcacgttta aacctcatta tctggctaag tataaacctc agggagaaaa ggggtttgtt 2640 tttgtttttc tcagtctata agctaacatt gagctgactt tcagagtcca ggcaaatatg 2700 tttggtgggt caccacccag aaaggaattc tcttagcact gaatcagggc tctgtatgta 2760 aagtataaat cccctaagag aactcctcac cctcctacac agacacattg gtgcatgcac 2820 acacacccca ctctctgcac agagagcatc tgagctagga gctggcaagt ggggcaccag 2880 tcctgtagca aagaggcaca ccacacacac acacacacac acacacacac actctctctc 2940 tctctctctc tcactcacac acacacacac acacacacac acacgcttct cccttgcttg 3000 ggaatctggg agaagaaccc cccaccccca cccctgccct ccataggcat tgtgtaggtg 3060 agagaaagag ggaggagtga gagagaacac acagaggggc ccaaggaggt gccaggccat 3120 tagcagggcc cctccttgag aaacccctct gcaggagctt ctcctgccgc cagccaggtt 3180 ggaggtggag tagttcagaa tcaactgacg cagccgggaa ttgagctttg caaagccact 3240 tgcaaggaag ggaagcatct gcccaaccct cccccaccgc gcgccctgga tcctctgcct 3300 gccccctccc ccgtgacgtc accctagtcc tgtcccgggg agcctgcaaa gcctctcaga 3360 ttcaaactgc tagacgcact gctgccacc g ccaccgaatt ggaaacgcgc gcccaggctc 3420 cgtcgtcgcc ttcgcccgcc gaccgggcca gccggctctc cgacctccct acagaatcgc 3480 accccagtcc ctccctggca gctcggcttc cctcagctcc aactcttctc ttccgctcct 3540 gcctcctgtc ggatttttaa tttctgcgca cccccagtca aattaaatca accaacaaaa 3600 agcagggcat cccccctgga agcagcgtct tattttacct tgttctccca cttcctgaag 3660 atgctaaact cctggtggac tgcagaggag agggattcag tcttctcctg atgtgtgagt 3720 aacccccacc tcgcactgtc tttcccatct ctatctctcc tctacacctg ccgccagccc 3780 cctgattcct gattttccca cccccttttt gcgctttttt tttttttcct aaagcgattg 3840 cgatttctgc tgggagctca agacgggcga gctgcccgag atctcttcga gataccccag 3900 gggaggagga gatgggcagg atttagtagg acaactcggt tactaatgac ttggcggctg 3960 gctgcgaccc cccgggaaat caggtgcaag catgtgtgtt cccggggcgc gtgtgtgggt 4020 ggcctcggga tgggggaata gggagcggag aaaagaaacc gctttggaaa atgcaatgat 4080 ttcattctgc cgtgttgcta accccctcat tctccctcgc tcccactccg cctccttgct 4140 ttaccatttt taatcgggct tccttgtttc tttcttccct gcacccgctt cttccccctg 4200 cccccaccta aggtttgcct gtaggtacct gagt tga cac cga agg tgc cta aag 4255 His Arg Arg Cys Leu Lys 1 5 atg ctg agc ggc gtt tgg ttc ctc agt gtg tta acc gtg gcc ggg atc 4303 Met Leu Ser Gly Val Trp Phe Leu Ser Val Leu Thr Val Ala Gly Ile 15 20 tta cag aca gag agt cgc aaa act gcc aaa gac att tgc aag atc cgc 4351 Leu Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg 25 30 35 tgt ctg tgc gaa gaa aag gaa aac gta ctg atacta aac tgt gag aac 4399 Cys Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn 40 45 50 aaa gga ttt aca aca gtt agc ctg ctc cag ccc ccc cag tat cga atc 4447 Lys Gly Phe Thr Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile 55 60 65 70 tat cag ctt ttt ctc aat gga aac ctc ttg aca aga ctg tat cca aac 4495 Tyr Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn 75 80 85 gaa ttt gtc aat tac tcc aac gcg gtg act ctt cac cta ggt aac aac 4543 Glu Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn 90 95 100 ggg tta cag gag atc cga acg ggg gca ttc agt ggc ctg aaa act ctc 4591 Gly Leu Gln G lu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu 105 110 115 aaa aga ctg cat ctc aac aac aac aag ctt gag ata ttg agg gag gac 4639 Lys Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp 120 125 130 acc ttc cta ggc ctg gag agc ctg gag tat ctc cag gcc gac tac aat 4687 Thr Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn 135 140 145 150 tac atc agt gcc atc gag gct ggg gcattc aaa ctt aac aag ctc 4735 Tyr Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu 155 160 165 aaa gtg ctc atc ctg aat gac aac ctt ctg ctt tca ctg ccc agc aat 4783 Lys Val Leu Asleu Asleu Leu Leu Leu Ser Leu Pro Ser Asn 170 175 180 gtg ttc cgc ttt gtc ctg ctg acc cac tta gac ctc agg ggg aat agg 4831 Val Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg 185 190 195 cta aaa gta atg cct ttt gct ggc gtc ctt gaa cat att gga ggg atc 4879 Leu Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile 200 205 210 atg gag att cag ctg gag gaa aat cca tgg aat tgc act tgt gac tta 4927 Met Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu 215 220 225 230 ctt cct ctc aag gcc tgg cta gac acc ata act gtt ttt gtg gga gag 4975 Leu Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu 235 240 245 att gtc tgt gag act ccc ttt agg ttg cat ggg aaa gac gtg acc cag 5023 Ile Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln 250 255 260 ctg acc agg caa gac ctc tgt ccc aga aaa agt gcc agt gat tcc agt 5071 Leu Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser 265 270 275 cag agg ggc agc cat gct gac acc cac gtc caa agg ctg tca cct aca 5119 Gln Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr 280 285 290 atg aat cct gct ctc aac cca acc agg gct ccg aaa gcc agc cgg ccg 5167 Met Asn Pro Ala Lela Asn Pro ThrArg Ala Pro Lys Ala Ser Arg Pro 295 300 305 310 ccc aaa atg aga aat cgt cca act cct cga gtg act gtg tca aag gac 5215 Pro Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp 315 320 325 agg caa agt ttt gga ccc atc atg gtg tac cag acc aag tct cct gtg 5263 Arg Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val 330 335 340 cct ctc acc tgt ccc agc agc tgt gtc tgc acc tct cag agc tca gac 5311 Pro Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp 345 350 355 aat ggt ctg aat gta aac tgc caa gaa agg aag ttc act aat atc tct 5359 Asn Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser 360 365 370 gac ctg cag ccc aaa ccg acc agt cca aag aaa ctc tac cta aca ggg 5407 Asp Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly 375 380 385 390 390 aac tat ctt caa act gtc tat aag aat gac ctc tta gaa tac agt tct 5455 Asn Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser 395 400 405 ttg gac tta ctg cac tta gga aac aac agg att gca gtc att cag gaa 5503 Leu Asp Leu Leu His Leu Gly Asn Asn Arg Ila Val Ile Gln Glu 410 415 420 ggt gcc ttt aca aac ctg acc agt tta cgc aga ctt tat ctg aat ggc 5551 Gly Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly 425 430 435 aat tac ctt gaa gtg c tg tac cct tct atg ttt gat gga ctg cag agc 5599 Asn Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser 440 445 450 ttg caa tat ctc tat tta gag tat aat gtc att aag gaa att aag cct647 Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro 455 460 465 470 ctg acc ttt gat gct ttg att aac cta cag cta ctg ttt ctg aac aac 5695 Leu Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Asn 475 480 485 aac ctt ctt cgg tcc tta cct gat aat ata ttt ggg ggg acg gcc cta 5743 Asn Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu 490 495 495 500 acc agg ctg aat ctg aga aac aac cat ttt tct cac ctg ccc gtg aaa 5791 Thr Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys 505 510 515 ggg gtt ctg gat cag ctc ccg gct ttc atc cag ata gat ctg cag gag 5839 Gly Val Leu Asp Gln Le Ala Phe Ile Gln Ile Asp Leu Gln Glu 520 525 530 aac ccc tgg gac tgt acc tgt gac atc atg ggg ctg aaa gac tgg aca 5887 Asn Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr 535 540 545 5555 0 gaa cat gcc aat tcc cct gtc atc att aat gag gtg act tgc gaa tct 5935 Glu His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser 555 560 565 cct gct aag cat gca ggg g 5954 Pro Ala Lys His Ala Gly 570 <210> 20 <211> 5446 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2564) .. (4138) <400> 20 taggtctgcg ccctggaggg aggtgtagaa agaggtacat ggagaacaag tttgtcaatc 60 catctgaact tcagttgcct tacctgtaag gcagccgtgt ctgtgttttt gtctcgcaga 120 attagagccc attgggaacg atgccaccac cgtcagacat tgtcaaagtg gccattgagt 180 ggccaggtgc taacgcccag ctccttgaaa tcgaccagaa acggcccctg gcatccatta 240 tcaaggaagt ttgtgatggg tggtcgttgc caaacccaga gtattatacc ctccgttatg 300 cagatggtcc tcagctgtac atcaccgaac agactcgcag tgacattaag aatgggacaa 360 tcttacaact ggctatctcc ccgtcccggg ctgcacgcca gctgatggag aggacccagt 420 catccaacat ggagacccgg ctggatgcca tgaaggagct ggccaagctc tctgccgacg 480 tgactttcgc tactgagttc atcaacatgg atggcatcat tgtgctgaca aggctcgtgg 540 aaagtggaac caagctcttg tcccaattgc agggtatgtg agccagccca tggtggacgt 600 gtcaatcctt cagaggtccc tggccatcct ggagagcatg gtcttgaaca gccagagtct 660 gtaccagaag atagccgagg aaatcaccgt gggacagctc atctcacacc tccaggtctc 720 caaccaggag attcagacct acgccattgc actgattaat gcactttttc tgaaggctcc 780 tgaggacaaa cgacaggaca agcaccttaa tcctctagac ctgcctgtca ctgtaagtag 840 cactgccatg tggaaagggc cccagctctt gcaggtgggg aagtcaaagc taggcaagaa 900 tctcatggtc tgatctagat gttcagggca tgccaagacc cagggaaagg ttgtgtgctg 960 tgaatctcct ttgtcaggac acttagggaa gtactgcaga ttagagtcac agaaaggatt 1020 aagggggtac ctgccccagg gagtgtggcc ccagccttcc tttataactt gcctttgcat 1080 gggtctgtag ttcaactagg gcagaccaga ctcagaaaca gctcgtaact ttgatctaga 1140 caataccatg gatgcgtcac cttcttactt gctttagtgg aagagaaaag gtatccgtgc 1200 cctttttgga ctcttactag accgtgggaa tccgaaaagg tttagacaat cgacaaaagg 1260 gaatttggat gctcatttct tcattatagg gagctttaga gaggtcagct ttgcgaggag 1320 atgaaagggg ataagtgcct ccccctgaca ccacagagaa gcttttggtc taagaccttt 1380 atattctagc tgcagaccac tgtcaattac ccaccttatg agttgtccac agcaagattt 1440 aatctcagtc gacctcctat agttaccaga gaagtttcta ggccactgtc ctcctctgct 1500 agccagtatg tattcagaga atgcaaagta aaatttaatg ttcctggcag cattagccat 1560 ttggaatatg gctagaaatc cagaagtgtg acagaggggc ctttcagctc tgagaaaaat 1620 gacacagagc tcacagatac tactccatag gagaggtgtg acagctccct caggcccact 1680 gatttaggat tctctata aa attaaatgaa ggcagcagtt tagaaaatga agtcatggta 1740 attaacatca gtaagaagtg atggtcgaca ctggaaggag gagacaagaa ttatgaaaag 1800 ctgtcagaaa aattaaaggc attgtaatct gggaccattt tgtttatggg aaaatagctt 1860 cacatctcag tagctcctca gggtatcaca gtgtcacaac acagaataat cactgatgtt 1920 ctttttgatg aagccgactc cttagcagtg attaaattat cactgtagtc acttcagaaa 1980 taaatgtata taatatgtct ttaaaagatt tgcataagaa tggtcaaaat aatgattctg 2040 agagaaccct taaagctttg ctccctggaa gattcattta tgtaggaaac ttgatttcct 2100 gggtgggcta aataaataaa gcataactat caaagtctgg atcaaatatt ataaaaaagg 2160 tgagcctgtt ataaaaaatt acccaaaaca ccagactcat tgttctctaa gccagttaga 2220 acggaatcct agactactta ctgttgtaga gcgtccagac cccagccgtc tgctgtaggg 2280 tgggaggggg ttgctggacc aaagcccttc cttgtttgga gtcagtgctt cactagagtt 2340 ccttctagcc ttagcagtgg ggtctacctg gcacgatgca tgtggcttag aaaccatcac 2400 actgctctgt gtccatgtgc aatgtccttg tgacacaagc gtctcatctt caagcagtcc 2460 tcatctctct ttgaagacag tggagttgat tgtgccatta ggaaaggaaa tcctatttga 2520 attaatttgc actcacaaaa ata gggaatg ttgcagagtg taa aat aca tct gat 2575 Asn Thr Ser Asp 1 ggt cag tgg att ttc gtt cat tca ccc act ttt cat ttg gga gga aaa 2623 Gly Gln Trp Ile Phe Val His Ser Pro Thr Phe His Leu Gly Gly Lys 5 10 15 20 aaa ttt aag aaa gca aaa aag gcc cag aat ttt gac atc acc ttc ctc 2671 Lys Phe Lys Lys Ala Lys Lys Ala Gln Asn Phe Asp Ile Thr Phe Leu 25 30 35 tcg ata gta gtc aca ggt gtg tgc ctg cca ccc tcc ttt gct 2719 Ser Ile Val Val Thr Gly Val Cys Leu Pro Pro Cys Leu Ile Phe Ala 40 45 50 tat ttt cct cca cag gat atg gca aat gca ttt gca cag aag cat ctc 2767 Tyr Phe Pro Pro Gln Asp Met Ala Asn Ala Phe Ala Gln Lys His Leu 55 60 65 cgg tct ata atc ctg aat cat gtg atc cga ggg aac cgc ccc atc aaa 2815 Arg Ser Ile Ile Leu Asn His Val Ile Arg Gly Asn Arg Pro Ile Lys 70 75 80 act gag atg gcc cat cag cta tat gtc ctt caa gtc cta acc ttt aac 2863 Thr Glu Met Ala His Gln Leu Tyr Val Leu Gln Val Leu Thr Phe Asn 85 90 95 100 ctt ctg gaa gaa agg atg atg acc aag atg gac ccc aat gac cag gct 2911 Leu Leu Gl u Glu Arg Met Met Thr Lys Met Asp Pro Asn Asp Gln Ala 105 110 115 caa agg gac atc ata ttt gaa ctg agg agg att gca ttt gac gca gag 2959 Gln Arg Asp Ile Ile Phe Glu Leu Arg Arg Ile Ala Phe Asp Ala Glu 120 125 130 tct gat cct agc aat gcc cct ggg agt ggg acc gaa aaa cgc aaa gcc 3007 Ser Asp Pro Ser Asn Ala Pro Gly Ser Gly Thr Glu Lys Arg Lys Ala 135 140 145 atg tac aca aag gac tac aaa atg ctg gga ttt acc aac cac atc aat 3055 Met Tyr Thr Lys Asp Tyr Lys Met Leu Gly Phe Thr Asn His Ile Asn 150 155 160 cca gcc atg gac ttt acc cag act cct cct gga atg ctg gcc ttg gac 3103 Pro Ala Met Asp Phe Thr Gln Thr Pro Pro Gly Met Leu Ala Leu Asp 165 170 175 180 aac atg ctg tac ttg gct aaa gtc cac cag gac acc tac atc cgg att 3151 Asn Met Leu Tyr Leu Ala Lys Val His Gln Asp Thr Tyr Ile Arg Ile 185 190 195 gtc ttg gag aac agt agc cgg gaa gac aaa cat gaa tgc ccc ttt ggc 3199 Val Leu Glu Asn Ser Ser Arg Glu Asp Lys His Glu Cys Pro Phe Gly 200 205 210 cgc agt gcc att gag ctc acc aaa atg ctc tgt gag atc ctg ca gtt 3247 Arg Ser Ala Ile Glu Leu Thr Lys Met Leu Cys Glu Ile Leu Gln Val 215 220 225 ggg gaa cta cca aat gaa gga cgc aat gac tac cac ccg atg ttc ttt 3295 Gly Glu Leu Pro Asn Glu Gly Arg Asn Asp Tyr Pro Met Phe Phe 230 235 240 acc cat gac cga gcc ttt gaa gag ctc ttt gga atc tgc atc cag ctg 3343 Thr His Asp Arg Ala Phe Glu Glu Leu Phe Gly Ile Cys Ile Gln Leu 245 250 255 260 ttg aac aag acc tgg aag gag atg agg gca aca gca gag gac ttc aac 3391 Leu Asn Lys Thr Trp Lys Glu Met Arg Ala Thr Ala Glu Asp Phe Asn 265 270 275 aag gtt atg caa gtc gtc cga gag caa atc act cga gct ttg ccc tcc 3439 Lys Gln Val Val Arg Glu Gln Ile Thr Arg Ala Leu Pro Ser 280 285 290 aaa ccc aac tct ttg gat cag ttc aag agc aaa ttg cgt agc ctg agt 3487 Lys Pro Asn Ser Leu Asp Gln Phe Lys Ser Lys Leu Arg Ser Leu Ser 295 300 305 tac tct gag att cta cga ctg cgc cag tct gag agg atg agt cag gat 3535 Tyr Ser Glu Ile Leu Arg Leu Arg Gln Ser Glu Arg Met Ser Gln Asp 310 315 320 gac ttc cag tcc ccg cca att gtg gag ctg agg gag aag atc cag ccc 3583 Asp Phe Gln Ser Pro Pro Ile Val Glu Leu Arg Glu Lys Ile Gln Pro 325 330 335 340 gag atc ctt gag ctg atc aag cag cag cgc ctg aac cgg ctc tgt gag 3631 Glu Ile Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Cys Glu 345 350 355 ggc agc agc ttc cga aag att ggg aac cgc cga agg caa gaa cgg ttc 3679 Gly Ser Ser Phe Arg Lys Ile Gly Asn Arg Arg Arg Gln Glu Arg Phe 360 tac tgc cgg ttg gca ctg aac cac aag gtc ctt cac tat ggt gac 3727 Trp Tyr Cys Arg Leu Ala Leu Asn His Lys Val Leu His Tyr Gly Asp 375 380 385 ttg gat gac aac cca caa ggg gag gtg aca tttga gag 3775 Leu Asp Asp Asn Pro Gln Gly Glu Val Thr Thr Phe Glu Ser Leu Gln Glu 390 395 400 aaa att cct gtt gca gac att aag gcc att gtc act ggg aaa gat tgt 3823 Lys Ile Pro Val Ala Asp Ile Lys Ala Ile Val Thr Gly Lys Asp Cys 405 410 415 420 ccc cac atg aaa gag aaa agt gct ctg aaa cag aac aag gag gtg ttg 3871 Pro His Met Lys Glu Lys Ser Ala Leu Lys Gln Asn Lys Glu Val Leu 425 430 435 435 gaa ttg gcc ttc t cc atc ctg tat gac cct gat gag acc tta aac ttc 3919 Glu Leu Ala Phe Ser Ile Leu Tyr Asp Pro Asp Glu Thr Leu Asn Phe 440 445 450 atc gca cct aat aaa tat gag tac tgc atc tgg att gac ggc ctc agt 39 Ala Pro Asn Lys Tyr Glu Tyr Cys Ile Trp Ile Asp Gly Leu Ser 455 460 465 gcc ctt ctg ggg aag gac atg tcc agt gag ctg acc aag agt gac ctg 4015 Ala Leu Leu Gly Lys Asp Met Ser Ser Glu Leu Thr Lys Ser Asp Leu 470 475 480 gac acc ctg ctg agc atg gag atg aag ctg cgg ctc ctg gac ctg gag 4063 Asp Thr Leu Leu Ser Met Glu Met Lys Leu Arg Leu Leu Asp Leu Glu 485 490 490 500 495 500 aac atc cag att cccga ccc atc ccc aag gag ccc agc 4111 Asn Ile Gln Ile Pro Glu Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser 505 510 515 agc tat gac ttt gtc tat cac tat ggc tgagcctgga gccagaaacg 4158 Ser Tyr Asp Phe Val Tyr His Tyr Gyr acggtaccca ggagaaggga ttttgggccc aggagaaaca cttacattct ggtgccttgt 4218 cttttgcttg tacagaatct gtagtgattt tggtggccag taaatgccag ccatttctca 4278 aacccacctc ggaccaccca gagtttcctc ttggtc cctg tctactaaga gtcatgaagg 4338 cagggtgctc tgcccactcc atcaccatga agcctgggat tgggccacga ggaacaaaca 4398 gcagatgccc ttgccttcca gtccaagaaa ctgcttcttg aaatggattt aacaacagcc 4458 actcaccttt tcctcctgag cctgctctct gatcagctgg atccccacgt gagcaacagc 4518 tggcccagga aaggctgcct gcagaggaca ggtgtgttgg gcgtgttgag agccttgaag 4578 tgactacctg tatcttagat ctgagtacaa gcctgaggct tttgcttttg tcttttttga 4638 tgagggctca ctccagcttc atatggtgcc aagacgttgc tgcttctgag gttggctcta 4698 acatctctgg tctttagagc caccagatct ctctggccca tacagatatc agagcagacg 4758 gaaatttctc cctgcaagcg ctcagtctca tcccagcaag tcaaagacct cctggccaag 4818 tcctgccctc ttaagtctcc aggaacgctg cagggaaaac ccagctgagg cctgggccta 4878 gactgtggtg aggtcactag attctactgc tcttccccca cattaatacc ttttccttcc 4938 tcagagagaa atctccccta acctgaattg cagccccctc cagtttgctt tcctttggcc 4998 ttccagaccc caggaagttg gccttccctt cctagtgcta tggtttctgc cattggccat 5058 gatttcaggg agctggctga ggccggctga ggccacacct gtgccagtgg ggcttccctg 5118 gtgctgcagc acttgtaaac cacacacaca gcctctctcc ctggacatac gttagcacat 5178 tggcattcag tattggtggc ctggcatggt aggtactacc caatgaagag tgtactatat 5238 attttcatta ctataggcca tacttataca gacgtgtata tatatttata taagatctac 5298 ctatcttagg atggaacctt ggggaaaaat aaaattgagg ggaagtaaaa agtatgtaac 5358 acttccagtt gtgagccaag attgtaacca gagagcagcc aggagcttcc tgtcagtaac 5418 catgttttca ataaatactc tttcatgt 5446 <210> 21 <211> 5133 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2921) .. (3589) <400> 21 cgcaggaagc agtttttctg tgtcccccgc cgaccccctg caggaggtaa gctgcatgag 60 ggcagtatca tgttgcctag caccttggcc cacatggagc aggtgccaag caggtatgta 120 ttgggtggag gaccctctcc ctgtggcctt ttatctattt gttctcacag ggtttgccag 180 gtttggctgc agttcatgtc acttgaggac attcctttcc agcgccgttg gctttgtggc 240 tgtggctctg tcacagctcc agctgtgcta tcattggtcc acattgtccc ctcccctatt 300 tgctgtgact cccatgggaa gatcctatct ctgttcctct cgcactgggg caaagcagtg 360 ctggcagggg gctggggaac tggcgggtgg cctctcctgg gcaggaagtc catggcaccc 420 aggtgctccc tgtgctccag aggggctggg gaggtttcat ggagtcaata ggcattggca 480 agctgacatg tcccctgtcc cacgcaggcc tgttgcagtc tccaaggcac catgaatgcc 540 atcgtggctc tctgccactt ctgcgagctc cacggccccc gcactctctt ctgcacggag 600 gtgctgcacg ccccacttcc tcaaggggat gggaatgagg acagtcctgg ccagggtgag 660 caggcggaag aagaggaagg tggcattcag atgaacagtc ggatgcgtgc gcacagcccc 720 gcagaggggg ccagcgtcga gtccagcagc ccggggccca aaaagtcgga catgtgcgag 780 ggctgccggt cacttgctgc agggcacccg ggatatatca gccatgataa agagacctcc 840 attaaatacg t cagccacca gcaccccagc cacccccagc tcttcagcat tgtccgccag 900 gcctgtgtcc ggagcctgag ctgtgaggtg agccttgtgg ccacagagcc tgtctctgtg 960 ggagcccaca tgctcccagg tgctctgggt gggctcggag ccagcattgc acagggaggc 1020 aggcactggt cctctctcag ggcggacccg cagatcagca cagcacaggg tacaggacgc 1080 ctcccttgtc cagaattgcg ggaggagtca tgttggactt gctgagcatt ttctgattga 1140 gtgctagctt ttgcacttta agcaccgaac ttttattatt tgtcctttct ttattattat 1200 tgttttcttt tttccttctt ttgtgtcagg gtctcgctct gtcgtccaga ctggagtgca 1260 gtggtgccgt catggttcac tgcaacctca aactcctggg ctcaagcgat cctcccgcct 1320 tagcctccca ggtggctggg accactggtg tgtgccacca tgctcaactg gggtttgttt 1380 tttgttgttg ttaagacaga gtctcactcg gttgcccagg ctggagtgca gtggtgcaat 1440 ctcggcttac tgcaacctcc accctgggtt taagtgattc ttctgtctca gctatcctga 1500 gtagctggga caacaggcgt gtgccaccat gcccggctaa ttttttgtat ttttagtaga 1560 gaagagattt caccatgttg gccgagctgg tcttgaactc ctgaccttgt gatttgcccg 1620 cctcggcctc ccgaagtgct gggattacag gtgggagcca ctgtgcccca cctttttaaa 1680 atttttttgt agagatga gg tctcagtatg ttgcccaggt tggtctcgaa ctcaagcaat 1740 cctctggctc atcctcccaa agcactagga ttacaggtgt gagccgccat gcccagccat 1800 gtgtgtctat tcttgatgga tgtattccta agataggaag catttctagg ttaggtggtt 1860 cattgcatca acatcacctt tttttattat ctcagtcctc attccaagtc tcagtgatga 1920 tcccgtgctg ctctcagcct gctgaggtgt ggatgatttc ttcctaaact acgtcgctgc 1980 tgctgttgct cttgactctg agctcaggtc tttgttacaa agaattcgtc gttcagttac 2040 taaacttcct tgtcattggt gtccacccag ttcgacacac caagctccct tactgttctc 2100 attcagtgtg gctgtgtgcc tgccctcaac tgtcctctcc ttttaatttc ctaccgctgg 2160 tctgctagca ggcagctcgg catgtctgtt agaattgtgt gttaaggaag agtaagtatg 2220 taatgaggag ggactgaaat cctcttataa gaataaagta tgtggggctg ggcatggtgg 2280 cccactcctg taatcccagc cctttgggag gccgaggccg gcagatcacc tgaggtcagg 2340 agttcgagac cagcctggcc aacatggtga aaccccctct ctaaaaaaaa tacaaaaaaa 2400 ttagccaggc gtggtggcac actcttacaa tcccagctac tcaggaggct gaggcaggag 2460 aattgcttga acccaggaga cggaggttgc agtgggccaa gatcacacca ctgcattcca 2520 gcctgggtga caagagcgag act ccatctc aaataaagaa agaaagaaag aataaaatgt 2580 gcggatttca gtgcagggag agtgcagtgg ctgctctgac ctgctggttc ttctgcatgc 2640 tccaggtgag taagctggta catttgagtc tgggagaggt gtgacatatg catgggagtt 2700 atttatggct caaggtggaa gaaaagcaat aagccttgtt accggccctt gcagtccaca 2760 atgacaagtg ttgttggaag cttgatcaca ggagcagaag agtacagtct tcggctctca 2820 tggcccccac tgtgccactc tccccgttat taacgctggc tgatttgtgc cagctgactc 2880 tgaaaagtct gaagaagagg ctttgatttg gtgtcactaa gcg agg aaa ggg ctg 2935 Ala Arg Lys Gly Leu 1 5 tct gag tcg ctg gtg tcc ctc cag gtc tgc cct ggc cgt gaa ggc ccc 2983 Ser Glu Ser Leu Val Ser Leu Gln Val Cys Pro Gly Arg Glu Gly Pro 10 15 20 atc ttc ttc gga gat cag cac ggc ttt gtg ttc agc cac acc ttc 3031 Ile Phe Phe Gly Asp Glu Gln His Gly Phe Val Phe Ser His Thr Phe 25 30 35 ttc atc aag gac agc ctg gcc agg ggc ttc cag cgc tgg tac agc atc Ascp Asp 3079 Phe Ser Leu Ala Arg Gly Phe Gln Arg Trp Tyr Ser Ile 40 45 50 atc acc atc atg atg gac cgg atc tac ctc atc aac tcc tgg ccc ttc 3127 Ile Thr Ile Met Met Asp Arg Ile Tyr Leu Ile Asn Ser Trp Pro Phe 55 60 65 ctg ctg ggg aag gtc cgg gga atc atc gat gag ctc cag ggc aag gcg 3175 Leu Leu Gly Lys Val Arg Gly Ile Ile Asp Glu Leu Gln Gly Lys Ala 75 80 85 ctc aag gtg ttt gag gca gag cag ttt gga tgc cca cag cgt gct cag 3223 Leu Lys Val Phe Glu Ala Glu Gln Phe Gly Cys Pro Gln Arg Ala Gln 90 95 100 agg atg aac aca gcc ttc acg cca ttc cta cac cag agg aac ggc aac 3271 Arg Met Asn Thr Ala Phe Thr Pro Phe Leu His Gln Arg Asn Gly Asn 105 110 115 gcc gcc cgc tcg ctg aca tcg ctg aca agt gat gac aac ctg tgg gcg 3319 Ala Ala Arg Ser Leu Thr Le Thr Ser Asp Asp Asn Leu Trp Ala 120 125 130 tgc ctg cac acc tcc ttt gcc tgg ctc ctg aag gcg tgt ggc agc cgg 3367 Cys Leu His Thr Ser Phe Ala Trp Leu Leu Lys Ala Cys Gly Ser Arg 135 140 145 ctg acc gag aag ctc ctg gaa ggt gct ccg acc gag gat acc ttg gtc 3415 Leu Thr Glu Lys Leu Leu Glu Gly Ala Pro Thr Glu Asp Thr Leu Val 150 155 160 165 cag atg gag aag ctc gct ggt gag gca ggg gtg ctg ttgcc Three 463 Gln Met Glu Lys Leu Ala Gly Glu Ala Gly Val Leu Leu Pro Gly Pro 170 175 180 tgg ccc gga tgg ccg tgg ggc ggt acc agc tgt ctg ctc tcc tgg cag 3511 Trp Pro Gly Trp Pro Trp Gly Gly Thr Ser Cys Leu Leu Ser Trp Gln 185 190 195 gaa tcg ctg agg gag gga aac gcg gct ctg aat cag ccc aga acg agc 3559 Glu Ser Leu Arg Glu Gly Asn Ala Ala Leu Asn Gln Pro Arg Thr Ser 200 205 210 ctt cgg gaa gct cac cct ccg tcg gtg tgattgttgt gattgttgtg 3609 Leu Arg Glu Ala His Pro Pro Ile Ser Val 215 220 atttcctgtc tcgtttgcct tgaccgccat gtgaaagaat ctgttcccca gctaggtggg 3669 gaaaattcac aggtgggctg tctgtagaga gaactggctg attaaaggct tctcgtcccg 3729 attttgtgat agccaagtgc ttggcctggt cgacggtctt tgctccttta caaataaagt 3789 gttctgtttc agttcgtccc aagttttcca tgaagggcag tggttccctg acctcccagg 3849 tgcctgggct tccccaggtt cctgatctgg ggcttggggc cctgtgtttg gggatcgtgg 3909 cactgtgtgc accagcctgg aagcactggg ccagtcttgg ccaagctttc catcagggat 3969 gatttgatct tggtgctaca ggtctgtggt acgaccattg ttccacacca catgtcatta 4029 ataatgcttc ccatgct tct gcttgcaaat gaccagcctt ccaaacagcc agagctgttt 4089 cgaggtgttt ctgcaggcag gtgcaggcgt gccctcaaat aagctttgcc aatggagtct 4149 cagcaagagc aaaacctggc ttcgcatcct ggatttgctt ctgacgtgca cccttccctt 4209 tgggtctcgt gatgtgaaat ggagatgttg tcatttgtga gggctccatg aagtttcgtt 4269 gaaatgacaa atactaattt cttcatctgt gaaatggaga taatagtgct gacctcagaa 4329 cagctgagag gactaaatga aatgatgttg gatgtagcca taaagaacga agtcaggcac 4389 tggtgcacgc ctggaatccc agctcttggg agaccgagac aggtggattg cttgagctca 4449 ggagtttgag accagcctga gcaacatagg gaggtccagt ctctacaaaa aatatgaaaa 4509 gtagctgggc gtggtggcgc atgcctgtag tcccactact tggaaggctt cgttgggagg 4569 atcacttgag cccagaagat tgaggctgca gtaagccgtg atcgtgccac tgcattccag 4629 cctgggcaac agagcgagac actgtctcaa ataaaaaaga tgggaatagt agacactggg 4689 ggctccagaa ggagggaggg agggaggaag gggaggaagg gctgaaatgc tttctattgg 4749 atactatctg ggcatattac ttcctgtggt tcactgtctg ggtgacagga ttcatagaag 4809 cccaaacttt agcaccacgc agcataccct tgtaacaaag ccgcacacgt acgccctcaa 4869 gctaaaacaa aagtggaccg gg aggccgag gtggggggat catgaggtca ggagtttgag 4929 accagcctgg cagataacgg tgaaaccccg tctctactaa aaataccaaa aaaagttagc 4989 cggacatggt ggcaggtgcc tgtagtccca gctacttggg aggctggggc agaagaatcg 5049 cttgaaccca ggaggcggag gttgcagtga gccgagattg cgccactgca ctccagcctg 5109 tgcgacagag tgagactccg tctc 5133 <210> 22 <211> 5027 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3503) <400> 22 gc ggc cgc acc tcg ctc tcc ctc ggg ctg ctg gtt gct gac ttt ggc 47 Gly Arg Thr Ser Leu Ser Leu Gly Leu Leu Val Ala Asp Phe Gly 1 5 10 15 gcc atg gtc aat aac cca cac ctg agt gat gtc cag ttt cag acg gac 95 Ala Met Val Asn Asn Pro His Leu Ser Asp Val Gln Phe Gln Thr Asp 20 25 30 agc ggg gag gtg ctt tac gcc cac aag ttc gtg ctt tat gcc cga tgc 143 Ser Gly Glu Val Leu Tyr Ala His Lys Phe Val Leu Tyr Ala Arg Cys 35 40 45 ccg ctc ctc atc cag tat gtg aac aat gaa ggc ttc tcc gct gta gag 191 Pro Leu Leu Ile Gln Tyr Val Asn Asn Glu Gly Phe Ser Ala Val Glu 50 55 60 gac ggg gtt ctg acc cag cgt gtc ctg ctg ggt gac gtg agc acc gag 239 Asp Gly Val Leu Thr Gln Arg Val Leu Leu Gly Asp Val Ser Thr Glu 65 70 75 gcc gcc cgc acg ttc ctg cac tat ctc tac act gcg gac act ggc 287 Ala Ala Arg Thr Phe Leu His Tyr Leu Tyr Thr Ala Asp Thr Gly Leu 80 85 90 95 cct cct ggc ctt agc tct gag ctg agc tcc ctg gcc cac agg ttt ggc 335 Pro Pro Gly Leu Ser Ser Glu Leu Ser Ser Leu Ala His Arg Phe Gly 100 105 110 gtg agt gag ctc gtt cac ctg tgc gaa cag gtg cct att gcc act gac 383 Val Ser Glu Leu Val His Leu Cys Glu Gln Val Pro Ile Ala Thr Asp 115 120 125 tca gag ggc aaa cca tgg gag gag aag gaa gca gag aat tgca agc 431 Ser Glu Gly Lys Pro Trp Glu Glu Lys Glu Ala Glu Asn Cys Glu Ser 130 135 140 agg gcc gag aat ttc cag gaa ctc ttg agg tca atg tgg gca gat gaa 479 Arg Ala Glu Asn Phe Gln Glu Leu Leu Arg Ser Trp Ala Asp Glu 145 150 155 gag gag gaa gcg gag act ttg ttg aaa tcc aag gac cac gaa gaa gat 527 Glu Glu Glu Glu Ala Glu Thr Leu Leu Lys Ser Lys Asp His Glu Glu Asp 160 165 170 175 caa gaa atac gt a gca gaa atg gaa gaa att tat gaa ttt gca 575 Gln Glu Asn Val Asn Glu Ala Glu Met Glu Glu Ile Tyr Glu Phe Ala 180 185 190 gct act cag cga aag ctt ctc cag gaa gaa agg gca gcg ggt gcc ggc gnc ggc Arg Lys Leu Leu Gln Glu Glu Arg Ala Ala Gly Ala Gly 195 200 205 gag gac gct gac tgg ctg gag ggt ggc agt ccg gtt tct ggg caa ctc 671 Glu Asp Ala Asp Trp Leu Glu Gly Gly Ser Pro Val Ser Gly Gln Leu 210 215 220 cta gca ggt gtc cag gtg cag aaa cag tgg gac aag gtg gag gag atg 719 Leu Ala Gly Val Gln Val Gln Lys Gln Trp Asp Lys Val Glu Glu Met 225 230 235 gag ccg ttg gag cca gga aga gat gag gcc gcc acc tgg gag aag 767 Glu Pro Leu Glu Pro Gly Arg Asp Glu Ala Ala Thr Thr Trp Glu Lys 240 245 250 255 atg gga cag tgc gct ctc ccg cca ccc cag ggc cag cac tca ggg gca 815 Met Gly Gln Cys Ala Leu Pro Pro Pro Gln Gly Gln His Ser Gly Ala 260 265 270 cgg gga gca gag gcc cct gag cag gag gcg cca gag gag atg ctt ggc 863 Arg Gly Ala Glu Ala Pro Glu Gln Glu Ala Pro Glu Glu Met Leu Gly 275 280 280 cat tcc agc tgc tcc agc cct tcc agg gac tgc cag gca gag aga aaa 911 His Ser Ser Cys Ser Ser Pro Ser Arg Asp Cys Gln Ala Glu Arg Lys 290 295 300 gaa ggc tct ctt ccg cac tca gat gat gcc ggg gat tac gaa cag ct Glu Gly Ser Leu Pro His Ser Asp Asp Ala Gly Asp Tyr Glu Gln Leu 305 310 315 ttc tca tca act cag gga gag atc tca gag ccg tcc caa ata aca agt 1007 Phe Ser Ser Thr Gln Gly Glu Ile Ser Glu Pro Ser Gln I le Thr Ser 320 325 330 335 gag ccc gag gaa caa agt ggc gct gtc agg gaa agg ggg ctg gag gtt 1055 Glu Pro Glu Glu Gln Ser Gly Ala Val Arg Glu Arg Gly Leu Glu Val 340 345 350 tct cat cgc ctg gct ccc tgg cag gca tct cca ccg cac ccg tgc cgc 1103 Ser His Arg Leu Ala Pro Trp Gln Ala Ser Pro Pro His Pro Cys Arg 355 360 365 ttc cta ttg ggg cct ccc cag ggc ggg agt ccc cgc ggg tct cat cac 1151 Phe Leu Leu Gly Pro Pro Gln Gly Gly Ser Pro Arg Gly Ser His His 370 375 380 aca agt ggg tcg tcc ctg tca aca ccc cgg tcc cgt ggc gga act tcc 1199 Thr Ser Gly Ser Ser Leu Ser Thr Pro Arg Ser Arg Gly Gly Thr Ser 385 390 395 cag gtg ggc tcc cca acc ttg ctg tct cca gct gtg cca tca aag cag 1247 Gln Val Gly Ser Pro Thr Leu Leu Ser Pro Ala Val Pro Ser Lys Gln 400 405 410 415 aaa agg gac agg agc atc ctc acg ctg tct aaa gag cca ggg cac cag 1295 Lys Arg Asp Arg Ser Ile Leu Thr Leu Ser Lys Glu Pro Gly His Gln 420 425 430 aaa ggc aaa gag cgt cgg tcc gtg ctg gag tgc aga aat aag ggg gtc 1343 Lys Gly Lys Glu Arg Arg Ser Va l Leu Glu Cys Arg Asn Lys Gly Val 435 440 445 ctg atg ttc cca gaa aaa tct ctg tct att gac cta acc cag tca aat 1391 Leu Met Phe Pro Glu Lys Ser Leu Ser Ile Asp Leu Thr Gln Ser Asn 450 455 460 cct gac cat tcg agc tcc aga tct cag aaa tct tca tcc aaa ctg aac 1439 Pro Asp His Ser Ser Ser Arg Ser Gln Lys Ser Ser Ser Lys Leu Asn 465 470 475 gaa gaa gat gag gtc atc ctc tta ctg gac tcg gat gag gag ggct 1487 Glu Glu Asp Glu Val Ile Leu Leu Leu Asp Ser Asp Glu Glu Leu Glu 480 485 490 495 cta gaa caa acc aaa atg aag tcc att tct agt gat cct ctg gaa gaa 1535 Leu Glu Gln Thr Lys Met Lys Ser Ile Ser Serp Pro Leu Glu Glu 500 505 510 aag aaa gct cta gaa att agc cct agg tcc tgt gag ctg ttt tcc atc 1583 Lys Lys Ala Leu Glu Ile Ser Pro Arg Ser Cys Glu Leu Phe Ser Ile 515 520 525 att gat gtt gat gca gat ca gaa cct tcc cag agc cca cca aga agc 1631 Ile Asp Val Asp Ala Asp Gln Glu Pro Ser Gln Ser Pro Pro Arg Ser 530 535 540 gaa gct gtg ctg cag cag gag gat gag ggg gtg ctg ccg gag aat cgg 1679 Glu Alu Leu Gln Gln Glu Asp Glu Gly Val Leu Pro Glu Asn Arg 545 550 555 ggc tct ttg ggc agg aga ggg gct ccc tgg ctg ttc tgt gac cgt gag 1727 Gly Ser Leu Gly Arg Arg Gly Ala Pro Trp Leu Phe Cys Asp Arg 565 570 575 agc agc ccc agc gag gcc agc acc aca gac acc tcg tgg ctg gtg ccc 1775 Ser Ser Pro Ser Glu Ala Ser Thr Thr Asp Thr Ser Trp Leu Val Pro 580 585 590 590 gcc acc ccg ctg gcc agc aga agc cgt gacgt tct tcc cag acc caa 1823 Ala Thr Pro Leu Ala Ser Arg Ser Arg Asp Cys Ser Ser Gln Thr Gln 595 600 605 atc agc agc ctc agg agc ggg ctg gcc gtg cag gcg gtg act cag cac 1871 Ile Ser Ser Leu Arg Ser Gly Leu Ala Val Gln Ala Val Thr Gln His 610 615 620 acg ccc agg gcc tca gta gga aac agg gaa ggg aac gaa gtc gca cag 1919 Thr Pro Arg Ala Ser Val Gly Asn Arg Glu Gly Asn Glu Val Ala Gln 625 630 635 aag ttt tct gtc atc agg ccc cag aca cca ccg ccc cag aca ccg tcc 1967 Lys Phe Ser Val Ile Arg Pro Gln Thr Pro Pro Pro Gln Thr Pro Ser 640 645 650 655 tca tgc ctc act ccc gtc tct cca gga act tct gac ggc aga a gg caa 2015 Ser Cys Leu Thr Pro Val Ser Pro Gly Thr Ser Asp Gly Arg Arg Gln 660 665 670 ggc cac aga agc cct tcc cgt ccc cac ccc ggg ggc cac ccg cac tcc 2063 Gly His Arg Ser Pro Ser Arg Pro His Pro Gly Gly His Pro His Ser 675 680 685 tct ccg ctg gct cca cat ccc atc tca ggg gac cgc gcc cac ttc agc 2111 Ser Pro Leu Ala Pro His Pro Ile Ser Gly Asp Arg Ala His Phe Ser 690 695 700 agg cgg ttc ctg aaa cac tcg ccg cct ggg cca agc ttc ctg aac cag 2159 Arg Arg Phe Leu Lys His Ser Pro Pro Gly Pro Ser Phe Leu Asn Gln 705 710 715 acc cca gcg ggt gaa gtg gtg gaa gtc gga gac agt gac gat gag cag 2207 Gly Glu Val Val Glu Val Gly Asp Ser Asp Asp Glu Gln 720 725 730 735 gag gtg gcc tcc cat cag gcc aac aga agc ccc cca ctg gac agt gac 2255 Glu Val Ala Ser His Gln Ala Asn Arg Ser Pro Pro Leu Asp Ser Asp 740 745 750 ccc cca att cca att gac gac tgc tgc tgg cac atg gag ccc ctc tcg 2303 Pro Pro Ile Pro Ile Asp Asp Cys Cys Trp His Met Glu Pro Leu Ser 755 760 765 765 cca att ccc att gac cac tgg aac ctg ga g cgg acc ggc ccc ctg agc 2351 Pro Ile Pro Ile Asp His Trp Asn Leu Glu Arg Thr Gly Pro Leu Ser 770 775 780 acc agc agc ccc agc cgc agg atg aac gag gcc gcc gac agc cgt gac 2399 Thr Ser Ser Pro Ser Arg Arg Met Asn Glu Ala Ala Asp Ser Arg Asp 785 790 795 tgt cgc tcc ccg gga ctc ctg gac acc acc ccc atc cga gga agc tgc 2447 Cys Arg Ser Pro Gly Leu Leu Asp Thr Thr Pro Ile Arg Gly Ser Cys 800 805 810 815 act acc cag agg aaa ttg caa gag aag tcc tcg ggc gcg ggc tcc ctg 2495 Thr Thr Gln Arg Lys Leu Gln Glu Lys Ser Ser Gly Ala Gly Ser Leu 820 825 830 ggg aac agc agg ccg agc ttt ctg gat gc tg gtt tgg 2543 Gly Asn Ser Arg Pro Ser Phe Leu Asn Ser Ala Leu Trp Asp Val Trp 835 840 845 gac ggg gaa gag cag agg cct cca gag acc cct cct ccg gcc cag atg 2591 Asp Gly Glu Glu Gln Arg Pro Pro Glu Thr Pro Pro Pro Ala Gln Met 850 855 860 cca agc gct ggt gga gct cag aag ccc gaa ggg tta gag aca ccc aaa 2639 Pro Ser Ala Gly Gly Ala Gln Lys Pro Glu Gly Leu Glu Thr Pro Lys 865 870 875 ggt gct aat cgg aa g aag aac ttg ccc ccc aaa gtg ccc ata acg ccg 2687 Gly Ala Asn Arg Lys Lys Asn Leu Pro Pro Lys Val Pro Ile Thr Pro 880 885 890 895 atg cca cag tat tcc att atg gag acg ccg gtg ctg aag aag gaact Met Pro Gln Tyr Ser Ile Met Glu Thr Pro Val Leu Lys Lys Glu Leu 900 905 910 gat agg ttt gga gtc cgc cct ctg cct aaa cgc cag atg gtt ctg aag 2783 Asp Arg Phe Gly Val Arg Pro Leu Pro Lys Arg Gln Met Val Leu Lys 915 920 925 ctg aag gag ata ttc cag tac act cac cag acc ctg gac tca gac tcc 2831 Leu Lys Glu Ile Phe Gln Tyr Thr His His Gln Thr Leu Asp Ser Asp Ser 930 935 940 gg gag gag agc cag tcc tca cagcc ctg ttg cag gcg cct cac tgc 2879 Glu Asp Glu Ser Gln Ser Ser Gln Pro Leu Leu Gln Ala Pro His Cys 945 950 955 cag acc ctc gcc tcc cag acc tac aag cct tca agg gca ggg gtc cat 2927 Gln Thr Leu Ala Ser Gln Thr Tyr Lys Pro Ser Arg Ala Gly Val His 960 965 970 975 gcc cag cag gag gcc acc aca gga cct ggg gcc cat agg ccc aag gga 2975 Ala Gln Gln Glu Ala Thr Thr Gly Pro Gly Ala His Arg Pro Lys Gly 980 985 990 cct gct aag acc aag ggc ccc cga cat caa agg aag cat cat gaa agc 3023 Pro Ala Lys Thr Lys Gly Pro Arg His Gln Arg Lys His His Glu Ser 995 1000 1005 atc aca ccc cca agc agg tcg ccc acc aag gag gca cct cca ggc ctc 3071 Ile Thr Pro Pro Ser Arg Ser Pro Thr Lys Glu Ala Pro Pro Gly Leu 1010 1015 1020 aat gat gac gcc cag atc cca gcc tct caa gaa tcc gtg gcc acc tct 3119 Asn Asp Asp Ala Gln Ile Pro Ala Ser Gln Glu Ser Val Ala Thr Ser 1025 1030 1035 gtg gat ggc agt gac agc tcc ttg agc tca cag agt tct tcc tcc tgt 3167 Val Asp Gly Ser Asp Ser Ser Leu Ser Ser Gln Ser Ser Ser Ser Cys 1040 1045 1050 1055 gag ttt gga gcg gca ttt gag tct gca ggt gaa gag gag ggc gag ggg 3215 Glu Phe Gly Ala Ala Phe Glu Ser Ala Gly Glu Glu Glu Gly Glu Gly 1060 1065 1070 gag gtc agt gcc tcg cag gca gcc gtg cag gcg gacg gac gacca Val Ser Ala Ser Gln Ala Ala Val Gln Ala Ala Asp Thr Asp Glu 1075 1080 1085 gcg ctg agg tgc tac atc cgc tcc aag ccg gcc ctg tac cag aag gtg 3311 Ala Leu Arg Cys Tyr Ile Arg Ser L ys Pro Ala Leu Tyr Gln Lys Val 1090 1095 1100 ctg ctg tac cag ccc ttt gag ctg cgg gag ctg cag gca gag ctg agg 3359 Leu Leu Tyr Gln Pro Phe Glu Leu Arg Glu Leu Gln Ala Glu Leu Arg 1105 1110 agg ca ctc cgt gtg tcc tcg cgc agg ctg ttg gac ttc ctg gac 3407 Gln Asn Gly Leu Arg Val Ser Ser Arg Arg Leu Leu Asp Phe Leu Asp 1120 1125 1130 1135 acc cac tgt atc acc ttc acc act gcc gcc acc cgag agg 3455 Thr His Cys Ile Thr Phe Thr Thr Ala Ala Thr Arg Arg Glu Lys Leu 1140 1145 1150 cag ggc agg agg cgg cag cct cgg ggc aag aag aag gtg gag cgg aac 3503 Gln Gly Arg Arg Arg Gln Pro Arg Gly Lys Lys Lys Val Glu Arg Asn 1155 1160 1165 tgatggggcc gtcccgaccc caccccaacc tgccatcagc agcccccacc cccgccattt 3563 gcagggagga cctgggacac ccagcgtggg tcaggcctcc acaggcattt ctgggtctgg 3623 ggaccacatc agctctgcgc tgtgatgatg accacagccc aatccagggc ttcctcctct 3683 gggctctgct ttctagggtg gcatttggag catgtcaccc actggattta cagactccag 3743 ccccttcctc tgtccgtgct cacagtgggt gtcctcgcgc aggctgttgg acttcctgga 3803 ca cccactgt atcaccttca ccactgccgc cacccgcagg gagaagctcc agggcaggag 3863 gcggcagcct cggggcaaga agaaggtgga gcggaactga tggggccgtc ccgaccccac 3923 cccaacctgc catcagcagc ccccaccccc gccatttgca gggaggacct gggacaccca 3983 gcgtgggtca ggcctccaca ggcatttctg ggtctgggga ccacatcagc tctgcgctgt 4043 gatgatgacc acagcccaat ccagggcttc ctcctctggg ctctgctttc tagggtggca 4103 tttggagcat gtcacccact ggatttacag actccagccc cttcctctgt ccgtgctcac 4163 agtgtgtctc cctttttggt tttctttttt tttttctttt tgagacagtc gtgctgtgtc 4223 acctaggctg gagtgcagtg gcacaatctc ggctcactgc aacctccgcc tcccgggttc 4283 aagcaattct cctgcctcag cctcccagat agctgggact acaggcacac gctgccacgc 4343 ccagctgatt ttttatattt tagtagaaac ggggtttcac catgttgctc aggctggtca 4403 caaactccag agctcaggca atccgcctgc tgcggcctcc caaagtgctg ggatcacagg 4463 cgccagccac tgcgcccggc ccagtgtgtc tcccttaacc caagagggcc ctcagctgtc 4523 ccagggggca gtgggccatc accagctggc cagggcatgg cctattctgc cacatttgcc 4583 accctctgag cccaccagtc ctgggcacag ctgccctaca cgtctgtcct gagatggacg 4643 tcaggtcc ag cctgccccgg cagcccgggc ccgtcctcct cagcactcag gccaacccca 4703 gccaccgcca gcctgagacc aggtgtcctg aggctccctg cactgccaca gcccagatgc 4763 agttctcctg acccagccgt gctacccgga cacttgtcat tgttaccagc agtctccaaa 4823 ctggacagtg cacaagggcc cagaacaact ctgatgccac cacaaaacaa acatgttcac 4883 tagcggattc cattctttgg gttgaagctg cctccagcct caggagcagt gtggaggaag 4943 atgagggcca ggaaagaagg aaaccttggt ttctccatcc ttgtgaatgt cctcgtctgt 5003 ttcaaataca gtgcagtcag tttt 5027 <210> 23 <211> 5369 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1558) .. (2667) <400> 23 gaattacagg cttgagccac tgcgcctggc ctggtctagt ctccttttag agatgagaaa 60 actgaggctc agggaggtaa cctgttcaag gtcatgaact gtcttaagac catagttgca 120 agtgacagag ctgggtctca gatgcaacct cagacctgat actgactcca gagctgtgcg 180 cctaagcact agagcacata gcctccttgc cccagggaaa gaacaatggg aggttgtggg 240 tgacctctgg gtctcagggc cctgggatat agggactgtg cctttttttt tttttttttt 300 ttgagacaaa gtttcgctct tgttgcccag gctggagtgc agtggcatga tctcagctca 360 ctgcaacctc cgcctcccag gttcaattga ttctcctgcc tcagcctccc aagtagctgg 420 gattacgggc atgtgccacc acacccggct aatttttgta tttttggtgg agatggggtt 480 tcgccatatt gatcaggctg gtctcgaact cctgacctca ggtgatccgc ctgccttggc 540 ctcccaaaat gctgagatta caggtgtgag tgcccatgcc tggcaggact gtgccttttg 600 cattttcaaa tgaaggaaat gagtatttct tgagtgttga ccgtgtgtcc ccccggcacc 660 gtgtcatgtg ctggttatgc acacacgata ttctgtttca tccccggaca gctctgtgag 720 cccccacccc agagcctgga gttgcagagg cagctacagg aggagcaggc ctcctaccag 780 cgcaagctgc aggcctacct ggagggccag cagcggcagg cccagcttgt gtgcagcggc 840 tgcagggtaa g tacaagaag aggtactcgg agctggagca gcagctgctg gagagatccg 900 gagagctgga gcagcagcgg ctaagggaca cagagcacag ccaagacctg cagagtgccc 960 tcatccggct ggaggaggag ccgcagagga gtgccagcct ggcccaggtg aaagccatgc 1020 tccgagaaca tctggaccag gcaggctcgg ccaaccaggc tctgagtgag gacatacaaa 1080 aggtgaccaa tgactggaca cgcagccgca aggagctgga gcagcgggag gcggcatgga 1140 ggcgcgagga ggaggacctg ctgcagctgg gaggggagct ggcccggaca tcacgagctg 1200 tccaggaggc gggcctggga ctgagcacgg gcctgtggct ggcaaagagc cgggccaagg 1260 cagccctgga gaagcaggcc ctgctgcagg cccagctgga ggagcagctg cgggacaagg 1320 tgctccacta gaaggacctg gcccagcagc agatgcaaag tgacctggac aaggctgacc 1380 tcagtgccag agtgacagag ctgggcctgg cagtgaagcg tcttcagaag cagaatccgg 1440 agaaggatca ggtcaacacg gacctcaccg agaagcttga ggccctggaa tccctgcggc 1500 tacaggagca ggtggccctg gagacagagg acggagaggg gctacagcag agcctaa 1557 ggg acc tgg cac agt ccg tcc tgt cgg aca cag agc ggc gtc cag ctg 1605 Gly Thr Trp His Ser Pro Ser Cys Arg Thr Gln Ser Gly Val Gln Leu 1 5 10 15 agc ggc tcc aag cgc ac c gcg gat gac tcc ttc ggc agc ctg cgg ggg 1653 Ser Gly Ser Lys Arg Thr Ala Asp Asp Ser Phe Gly Ser Leu Arg Gly 20 25 30 ctc tcg gcc cag cag acc ccg tcc cca ccg cgg cgc tcc tcg Leccu ggc 170 Ala Gln Gln Thr Pro Ser Pro Pro Arg Arg Ser Ser Pro Gly 35 40 45 cga ggc cgt tca ccc cgc cga ggc ccc tcc ccg gcc tgc tca gac tcc 1749 Arg Gly Arg Ser Pro Arg Arg Gly Pro Ser Pro Ala Cys Ser Asp Ser 50 55 60 tcc acg ctc gcc ctg atc cac tcc acc tta cac aag cac gag ctg cag 1797 Ser Thr Leu Ala Leu Ile His Ser Thr Leu His Lys His Glu Leu Gln 65 70 75 80 gtc cag gac atg cgt ggg cgc tat gag gca agc cag gac ctg ctg ggc 1845 Val Gln Asp Met Arg Gly Arg Tyr Glu Ala Ser Gln Asp Leu Leu Gly 85 90 95 acc ctg cgg aag cag ctt agc gac agc gag agt gag cgg cgg gcc cta 1893 Thr Leu Arg Lys Gln Leu Asp Ser Glu Ser Glu Arg Arg Ala Leu 100 105 110 gag gaa cag ctg cag cgc ctg cgg gac aag acc gac agc acc atg cag 1941 Glu Glu Gln Leu Gln Arg Leu Arg Asp Lys Thr Asp Ser Thr Met Gln 115 120 125 gcc cac gag gac gc c cag cgc gag gtg cag cgg ctg cgg agc gcc aaa 1989 Ala His Glu Asp Ala Gln Arg Glu Val Gln Arg Leu Arg Ser Ala Lys 130 135 140 gag ctc ctg aga agg gag aag agc aac ctg gcc cac agc ctg cag Leu Leu Arg Arg Glu Lys Ser Asn Leu Ala His Ser Leu Gln Val 145 150 155 160 gcc cag cag cag gcc aag gag ctg cgg cag gag cgg aag aag ctg cag 2085 Ala Gln Gln Gln Ala Lys Glu Leu Arg Gln Glu Arg Lys Lys Leu Gln 165 170 175 gct gcc cag gag gag ctg cgg cgc cag cgg tac tgg ctg ggg gaa gag 2133 Ala Ala Gln Glu Glu Leu Arg Arg Gln Arg Tyr Trp Leu Gly Glu Glu 180 185 190 cag gag gac gca ggt gag g cgg gtg cgc cgg gag ctt gag 2181 Gln Glu Asp Ala Val Gln Asp Gly Val Arg Val Arg Arg Glu Leu Glu 195 200 205 cgc agc cat aga caa ctg gag cag ctg gaa ggg aag cgc tca gtc ctg 2229 Arg Ser His Arg Glu Gln Leu Glu Gly Lys Arg Ser Val Leu 210 215 220 gcc aag gag ctg gtg gag gtg agg gag gcg ctg agc cgc gcc aca ctg 2277 Ala Lys Glu Leu Val Glu Val Arg Glu Ala Leu Ser Arg Ala Thr Leu 225 230 235 240 caa cgg gac atg ctg cag gcc gag aag gcc gag gtg gcc gag gcg ctg 2325 Gln Arg Asp Met Leu Gln Ala Glu Lys Ala Glu Val Ala Glu Ala Leu 245 250 255 acc aag gct gag ggc aga gga ggc ctc cct g cct gtc caa 2373 Thr Lys Ala Glu Gly Arg Gly Gly Leu Pro Ala Gly Leu Pro Val Gln 260 265 270 gct gag cgc cct caa cga gag cct tgc tca gga caa gtt gga tct gaa 2421 Ala Glu Arg Pro Gln Arg Glu Pro Cys Ser Gly Gln Val Gly Ser Glu 275 280 285 ccg cct tgt cac cca ggc cac agc tgg agg aag aaa agt gcg ccc tgc 2469 Pro Pro Cys His Pro Gly His Ser Trp Arg Lys Lys Ser Ala Pro Cys 290 295 300 agg gcc ggc agc ggc agg cga agc agg agg cca cag tgg cac ggg aag 2517 Arg Ala Gly Ser Gly Arg Arg Ser Arg Arg Pro Gln Trp His Gly Lys 305 310 315 320 agc agg agc ggc tgg agg cgc tgc ggt tgg aac agg agg tgg cgc gg Arg Ser Gly Trp Arg Arg Cys Gly Trp Asn Arg Arg Trp Arg Gly 325 330 335 agg gcc tgg agg gct ccc tat gag cgg cgg agc agg ccc agg agg cag 2613 Arg Ala Trp Arg Ala Pro Tyr Glu Arg Arg Ser Arg Pro Arg Arg Gln 340 345 350 tgg agc agc agc tcc cca cgc tgc atc atg agt gca gcc ggc tgc agg 2661 Trp Ser Ser Ser Ser Pro Arg Cys Ile Met Ser Ala Ala Gly Cys Arg 355 360 365 agc agc tagcgagaagacagac agacacag Ser Ser 370 tgtctgggca cccccgaccc aggcaaattg acacaaaaat taattttcac aaatactatc 2777 aatagaagtg actaataaat gtggcatcat gtcctgcctg tttatcccat gacaattagt 2837 atagtcgagc gtaacattgg cttccgttcc cttatagtag caacatgtag gagtttcatt 2897 taaagtgagg ataattttga ccttacagag tttctcccta cccctatcta ccattgccac 2957 ttgtggattg tcattttgcc atgactttct tttaaaaaat atcaataagc tctatacttc 3017 agtaatgtaa gtttgaattt catcctggct gcataagtca ctttccattt tgacaaagtc 3077 tagaaatatt tttctccatc tccttgaata tgggtaatgg atacctattg tggggcccac 3137 tctcaatctc atggttttat tttaatttag ttctcaatag atatgcctca gctgcttaaa 3197 aaccattgaa aatggcccat ggccttgtcc atctaacaga gtccagtaaa atcctgacaa 3257 tggaatgggg agagagacagatacgaccagacagacgacagacagacagacagacagacagacagacagacagacagacagacagacagacagcagacagacagacagacagacagacagacagacagacagacagacagacagacagacagacagacagagagacagacagagagacagacagacagacagacagacagagagacacagagagacagacagacagagacagagagacacagagacagagacagacagacagacagacagacagagcagacagagagagagacagagagacagagagagacagag tct agtagcatga gaccatgtct 3377 cacgaatgac cctaggctcc catgacaatg cctacctaag aaagctcaag gctgccaggg 3437 gaacttactt tagtctagcc aatacttgat gatggcagtt tcaggatctt tctttcttat 3497 agcacttact aagaagggaa tccttcctcc atccctttga tatatgtgtg tatctcctag 3557 ggacttcaat gtatctttgc ccaggatctg aaaggcaata cttttgaggt gtagtcctca 3617 ggaaggactg agcctctgtc ttccagtctc tgtgggaggt tagaatccta acttctaata 3677 ttgccagctg gcagacacag ctgtcctgat gaggcagaca tttaaaatga ccaatctttt 3737 gtaatgtttc acttgtgccc tgccccctgc cctctcccct gcctctctct cccattagaa 3797 tgccatcacc tctgcacaaa tgcgaacaga accagcccct tcctctacgg tcagtagtta 3857 ctgaataaaa ttggttttca tcgatttgac taatgtctga tatatctttg acaaaataag 3917 tgtgaatgat tgtttttaga gacacggcag ctgcaaagag aggcacagac atggcaggag 3977 agggaggggt cacctgaccc ttctcatttc ataggcatct attcctgcct ggtgtttatg 4037 agcctgagac ttggcagggc tgtcctggta tataactcca tggctctgca gcaagactcg 4097 aataggctgg tggtgacact tggtgtgacc acagtcacct tcaaagatgc cattaagggt 4157 tcacaagaaa atgaagggaa acagaaaaac tgattatgaa ag ttgttgcc tctcctgctt 4217 cttcatacag agtgtgtatg atattgctgt gtgatgttag actgcaactt agcccaacag 4277 ctgttctagt aattggcagt ttctcatcga gttaagccta cctgataaag aagcacgctt 4337 acatttattg attacccccg taaaatgaac aatacatcca acaagacttc tagcaaaaat 4397 gttcttatta acctcctttt tatactaagg aaaaactggg tacaacacaa atcttcatca 4457 acagaagaat accaactgtt atacagtcat aaaacgatcc cagaagttca ctccatacca 4517 tcaaaaccag gaacccacac tgatgcccct gatggcagaa aatcatgata caaaaatgag 4577 agaaacgaga gagagaaaat gtactagagt catggtagtg ggtaaaagcc aaagagctca 4637 gtttctactc atgatattca ttagaagaac caaaggaaca tgagccaaca gctgtaaggg 4697 tccaggtctg cacaaggtgc ctgttgggtg cagggttctg ttggctccag tgatatatct 4757 caggtgggct aatttttacg gacatagccg ctgcaaaaat ctatcaaaca ataataaagg 4817 gatagctact tgcatgctaa tttaccattg tatagaaggg agaacaggca tcagattgtt 4877 ttcgtcaaat aaaagcaaaa ccaagattta tgaagaaaag aggaaagagg aaaaaaaatc 4937 gcctgggacc tttgtgattt tgctcccctt ggataagaga cttgacagaa agctttcaaa 4997 gaggtcactg tggcctgtct tcttgagaca cacgacactt gttcacca cg gaaaacaatt 5057 acagatgttg gaggacttta aaatatccta gtttagcagt tcatcctatg ccacagaatc 5117 tgtgtgtgat gtccaccatg tccttctgtg gtacacccct tcagttaagc caggagggtg 5177 cctctccgct cagtggaata tcatacatca atgtgtagaa agtttgttgt gctggcaagt 5237 aaatgacaaa agggacattg atagaattag gaaacaaatt ggaatatgat ctgttaccgt 5297 tcccatggaa gataaatttg cagaatatac tcaaattaga agcattaaat aaacgctgta 5357 atttaaaatg gc 5369 <210> 24 <211> 5167 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4656) .. (4877) <400> 24 ggccagtgtg ttcagagtca ttgtctttcc ctccacacct gcctgtcctg tctctggtct 60 ggagtcacat ccactcgggt gctcaagcca gagcacaggg ccaccttggt tctttgtctt 120 cctccccatc ccctcgtccc aggtccaggt gcccctcctg tttgtaagcc tgtttctcac 180 ctcccagcat gtccttgtcc ggaggcgggt gttgaagagt gtggctcagc ctcactggca 240 tcctcgctca tgttactcca gagtctgcct gcggagtgcc tccctaatgg tctggactgg 300 ccagtctgcc tctgtctgtc ctgctgcaga ggcctttgca gccactctcc atggctcctg 360 ggtaaaaccc acaccgtacc ctcgtctgcc actccccact tcagctcccc caggactcct 420 ggtgcttttg cacaagtgct tcctcagccc agccccactc tctcttccga ctctgcggcc 480 aggtcagggg tggggcgctg aactgtgcgg gctgcgtctc ccagcctcct gctccaggct 540 tccttgaaac ccctcctgac tgcaggcagt gctcatcacg tggcactttc ctgtctgttt 600 cccaaccaga gtgggagctc tttgaacaca gggtctgtgc cttactgacc cctggtcctc 660 tgtgccccat gcaccttgtg gctcaggggt cagcagatgg cagtccctgg gcaaacccgg 720 cccctgtgag tttttatgaa cacagttgtg ttggaacaca gctaacaccc atttgttgtc 780 tctttttgtg ctccctctgt ggagttgagt agttgtgaca gagacttaaa acctgcagag 840 ctgaaaacat t gcctgactg ggccttcaca ttctcagggt ctggcccaaa tgaggtgcac 900 agtcgggtct ttcagtgagt ggtaacgacc ttgtgtatct gtggagcttt ccccacctgc 960 tgggaatgat gtcaggccct aactgcatcc atgcactgaa gcctcatggt ggccctgcag 1020 gtttagcagc cactggcagt tcctcccctc ttttcagatg aggaaactga caattgatta 1080 attaataact tgcccagcat ggcagttgct aagcaggggg acctgggatg ggaatgactg 1140 tctgcctcca gaccttgatg cttgcctgtg aatgacttga tgcttgcctg tgaatgaacg 1200 tgagcttcag ccttcacagg aaggaagaaa taaagggggt gtgggaagtg ctgcaagagg 1260 ggtactccta ggagaggtga ggggctgcca ctgtctcaga ggccgtggag gcctgaggaa 1320 gggccccagc ctccagcagc tcacgttagg gctgacatgt cacatcatac ttaatcaggg 1380 aatgtcaaga ttcagggcac ttactaagga caccctgaac acagggaagt cttctgttcc 1440 cacctggaac tttgtgtctc ccttgttcct taataactgc tgaggagttg tgatgaggtt 1500 cagcacacta agacgttgaa taggacagac ctgccgtttg gtttaaggtt taagtccccc 1560 atgcttctca aagtgggtga agtttaaaaa caggcaggtc ttcggtgaag ttcaagggat 1620 gtccatgaag ctggatgagc aggtagggtt cagagcgggg gtgatgtttc ctgggtgggt 1680 aggatgtctg cctgccctg a gtcagctgac ccagaccctc cccactgagg atgccctggg 1740 ccagcctcct gctgctatgg cccccttagg gaaccatacg gcatcgtggt tgctacagag 1800 ctccctggcg gaagactgcc tgtttgtttg attccgcacc ccctctggtg ctgtgtgctc 1860 ctcaggggtc aggaggcacc ctagaagcca gttttttctg ttaacatgat aggtgctccg 1920 tggggagtgc tgggggtgct ctgtgggtgt gagttggtgg tgatggcggc tggcgagttt 1980 gtaggtctca ggcgctgcgc atggagtatt tcacacgcat catccgagct ccgcgtcacc 2040 ctgtctttag gcccatcgtg taaaggagga atctgggttg agagtgtatg tagcagccct 2100 gggaatcggg gcccgttagc tcccgtgcct aatcactgcc ccaagtcgca gtggcagatt 2160 agaagtgagc tcttgagcct cctgaactag ccctcagtcc tgggctgtga cttcatgagt 2220 gtggtcccct cagctgtttg ctgggctggg tcgggccttt aaatagcctc ctaggtcact 2280 tgtggtcagg gccacggtgg ggcgttctgg ccttggacag ctacccagag gtgtggaatc 2340 cggcttccca ctcctcctcg ccaggtgccc gggggagccc tgggcttgct tcgggagctt 2400 ggacacagct tctggatctg gcttctcatt tcagaggtgg tggtgcagtg tgcagggcac 2460 tcgagatgtt tctgttacct tatgtatagt ggaggttgaa atggccagaa aaccacagca 2520 tgtttgagta gcagttagaa atct tctgtt ccatgccatc tcccactcct ggccatctcc 2580 attcattccg ggaagtctct gagttcttta aggtccacct cacatgccgc ctttgattcc 2640 tccctccttg tggcatgatt tggccaagta gtgttattga acacttacgc gaggctcaca 2700 agagcaaaag cacaacagtc ctgcctgagg ttcctggtct gggggaggaa caggccggcc 2760 tgctgtggcc tcagagcaga cccagaacac taggagccca gaagcctgac ttgggtggga 2820 cacagtgaat tctcaagcac ttctcctagg ggacaactcc agctgggtct tgaaggctga 2880 ataggagttg cttgtgaggg tgaagcagca ggcagcctgt gcggtggttg ctcagggcct 2940 gagggtagtg atgctgggga gtgctggcgg tggaccctgc tggaacgctg gtcaaaagag 3000 tgggggcagt agccagagag aaaaggctgg gccttctttc tgctttgaag cccgtcattg 3060 tgctctggct tgtgttatta gtacaacagg ggcctctcac ccacacaagc ccctcgaggg 3120 tgggcttcag ggagccgagg gcagtgagga gagcaccggg tctgcggcct gtcaggcccc 3180 agctttgtac ctcactaggt tcgtggcttt gagctcattt cttatttttt ctgaattggt 3240 ctttcatctg caggaaggga ctgtccctgc ctccctctga gggccactgt aaggcaggac 3300 atggattgcc tggggcaggg ccagccacat agtagatgtg gtctctgctg ggcacaggca 3360 gcgagaggag ggcacgcagg tgaatccag a gacttaatgg ccaagcccct caccgcctgc 3420 caggctttga tcaaagctgt gtccgctggc cggaaagtgt gtggcttccc ctccaccagg 3480 agtcttggat tctggcccac ataggaagat gagcacatgg tggataagta gaaactccca 3540 gcctggttcc cagtgtgatt cgtgagtggg acaaacctca gacagctctg cccaccgaaa 3600 gaagcgtaca cgttcctggc gtgtgctgtt tgtaacctgc gaaggcattt gggggaagct 3660 cagttccccg ccagataccg agcggtgctt ggaagggccc aggagaagag aagccaagaa 3720 agcccgtagc aaaggaacag tggagatgtg cgccctggac tgacttcttc ccttgtgcac 3780 atcactgcct gtgtcaaaag tagatccagc gcacccctca gctgtataca tttgtggagc 3840 tcacatttgt gtggtttgct gtgctgaaac ttaactgtct taaagacccc catttccagg 3900 aaactgccaa gaacttttgt tatctaagag tgtttgtaag atactcagat aggagcagtg 3960 tattgaatga aagtttatct gaatagctgc tgttttccag gccccacatc tgtagaatga 4020 atgttgaatt aagaggtcta ctagactcag acctggaacc caggattgac tctcaacccc 4080 actccttcct tgttaaggaa atgggctcag ggtccccttg tccgtccaga tgagattagg 4140 catgtcaaag ccttggcact attcccagcc tatcttgatt catggatttt tttttcttat 4200 agcagagaaa gtccattgtc cttgcccgat taaa aagggt gaagatgggc tgggcacagt 4260 ggctcatgcc cgtaatccca gaactttagg aggccgaggc aggtggatca cctgaggtca 4320 ggaattcgag accagcctgg ataacatgat gaaacctcgt ctctactaaa gatacaaaaa 4380 ttagccgggc gcgatagcag gcgcctgtaa ttgcagctac ttgggaggct aaggcaggag 4440 aattgctgaa cctaggaggt ggaggttgca gtgagctgag atcgcgccac tgcaccccag 4500 cctgggcgac agagtgacat tccgtctcaa aaaaaaggtg aagatgataa aaaaaaaagt 4560 agaggaaaaa cttcctgcct cggacttccc tctagattgt ttgcttgggt ccagatgcct 4620 gaaagagttt tggttttaga attccatcct aatga ccc agg tgc ctt tat ctg 4673 Pro Arg Cys Leu Tyr Leu 15 atg gtt ctc atg tat gtt ttt gct aac cag gag ctg aga gaa gat aat 4721 Met Val Leu Met Tyr Val Phe Ala Asn Gln Glu Leu Arg Glu Asp Asn 10 20 atc att tta att gaa acc aag gcc atg ctg gag gaa cag ctg act gct 4769 Ile Ile Leu Ile Glu Thr Lys Ala Met Leu Glu Glu Gln Leu Thr Ala 25 30 35 gct cgg gcc cgg ggc gat aaa gtc cat gag ctg gaa gag aac ctg 4817 Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu Lys Glu Asn Leu 40 45 50 cag ctg aaa tcc aa g ctt cac gac ctg gaa ttg gta ctg cag gct gtg 4865 Gln Leu Lys Ser Lys Leu His Asp Leu Glu Leu Val Leu Gln Ala Val 55 60 65 70 ttg tta cta cat tgaaaacaga ttgggctcgg gcacagtggc tcatgcctgagutgagcctgccatg Leg gagcgcagga gttctaaccc 4977 tggcaaccta gcgaggcccc atctctacga aaactaaata attgggcatg gtggtgtgag 5037 cctgtagttc catctacttg ggagagactg aggcaggagg gttgcttgag gttgcttgag cctgggaggccat gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gag cg <210> 25 <211> 5363 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (653) .. (1960) <400> 25 gtacagtggt gcgatcacag ctcactgcac tccagcctag gcagcacagc tagactgtct 60 caaaaagaaa aaagaaagta gggaaatgag tgtttgaaag agcagaaagc tatggaattc 120 taacaagata gatgtttata atagggtgtt tctgtatcta acacatattt atgttcaaaa 180 tagttccatt acaaaatgta actttttttg gttttctatg tttattttag gggtttgatg 240 taaaaggcca attgctcaag atctgcttct atacaactaa taaaaatata cgtgactttt 300 tggtaggtaa aggtgagact acatagtata cattttctag aaagcctggg tgaaaaactt 360 ggaagaaaac cttggaagaa aaaccttaag taattttaat gttcaactaa tatctaataa 420 gtaaaagtgt gacaacccct tcatcttttt ttccccttca tctttcttca atgactattt 480 tacatttgtg gcaaaagaaa atttgtgtta acatacatta actcaaatgt tcaaaatata 540 attcttgaat ggcatattat ctcatgactt tttttaataa tctttaattc ccagcactac 600 cttatttgat aatctcatga cattttttgc aaaagtgctt gattttttgt aa agt cac 658 Ser His 1 tgc ttt aat tac ttt tta ttc aag gtt gaa att tta aaa gaa aaa aat 706 Cys Phe Asn Tyr Phe Leu Phe Lys Val Glu Ile Leu Lys Glu Lys Asn 5 10 15 tat ttt tct gaa aaa gag aaa aga act ata gac ttc gtg cat caa gtt 754 Tyr Phe Ser Glu Lys Glu Lys Arg Thr Ile Asp Phe Val His Gln Val 20 25 30 gag aag ctt tat ttg gga cat ttc caa gaa aat atg caa atc cag tca 802 Glu Lys Leu Tyr Leu Gly His Phe Gln Glu Asn Met Gln Ile Gln Ser 35 40 45 50 ttt ccc agg tac tgg ata aag gaa caa gat ttt ttc aag cac aag tct 850 Phe Pro Arg Tyr Trp Ile Lys Glu Gln Asp Phe Phe Lys His Lys Ser 55 60 65 gtt ttg gac tca ttc ctg aaa tat gat tgt aaa gat gaa ttt aac aaa 898 Val Leu Asp Ser Phe Leu Lys Tyr Asp Cys Lys Asp Glu Phe Asn Lys 70 75 80 cag gac cat aga att gtg tta aat tgg gct ctg tgg tgg gat caa cta 946 Gln Asp His Arg Ile Val Leu Asn Trp Ala Leu Trp Trp Asp Gln Leu 85 90 95 aca caa gaa tcc atc ctt ctc ccc agg ata agt cca gaa gaa tac aaa 994 Thr Gln Glu Ser Ile Leu Leu Pro Arg Ile Ser Pro Glu Glu Tyr Lys 100 105 110 tca tat tcc cct gaa gcc ctc tgg aga tac ctc aca gct cgc cat gat 1042 Ser Tyr Ser Pro Glu Ala Leu Trp Arg Tyr Leu Thr Ala Arg His Asp 115 120 125 130 tgg tta aac att atc tta tgg att gga gaa ttt caa acc cag cat agt 1090 Tr p Leu Asn Ile Ile Leu Trp Ile Gly Glu Phe Gln Thr Gln His Ser 135 140 145 tat gct tca ctt cag cag aac aaa tgg ccc ctt ctg act gtt gat gtt 1138 Tyr Ala Ser Leu Gln Gln Asn Lys Trp Pro Leu Leu Thr Val Asp Val 150 155 160 att aac cag aat act tcc tgt aac aac tac atg agg aat gaa att tta 1186 Ile Asn Gln Asn Thr Ser Cys Asn Asn Tyr Met Arg Asn Glu Ile Leu 165 170 175 gat aag ctg gcc agg aat ggg gtt ttt ttg gca tct gaa ctg gaa gac 1234 Asp Lys Leu Ala Arg Asn Gly Val Phe Leu Ala Ser Glu Leu Glu Asp 180 185 190 ttt gaa tgc ttc ctc cta aga ctg agc cgt att gga ggt gta ata Cag 128u Phe Glu Arg Leu Ser Arg Ile Gly Gly Val Ile Gln 195 200 205 210 gat acc ctc cct gtt caa aac tac aag acc aaa gaa ggt tgg gat ttc 1330 Asp Thr Leu Pro Val Gln Asn Tyr Lys Thr Lys Glu Gly Trp Asp Phe 215 220 225 cat tct caa ttc att ctc tat tgt ttg gag cac agt ctg cag cat ctt 1378 His Ser Gln Phe Ile Leu Tyr Cys Leu Glu His Ser Leu Gln His Leu 230 235 240 ctt tat gtc tac ctt gac tgt tac aaa ctt agt cct gaa aat tgt ccc 1426 Leu Tyr Val Tyr Leu Asp Cys Tyr Lys Leu Ser Pro Glu Asn Cys Pro 245 250 255 ttt ttg gaa aaa aaa gag tta cat gaa gca cac cct tgg ttt gaa ttt 1474 Phe Leu Glu Lys Lys Glu Leu His Glu Ala His Pro Trp Phe Glu Phe 260 265 270 tta gtt cag tgt cga caa gtt gcc agt aac tta aca gat ccc aaa ctg 1522 Leu Val Gln Cys Arg Gln Val Ala Ser Asn Leu Thr Asp Pro Lys Leu 275 280 285 285 290 atc ttc cag gct agc ctt gca aat gct cag att ttg att ccc acc aat 1570 Ile Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr Asn 295 300 305 cag gcc agt gta agc agt atg cta ttg gaa gga cat acc ctc ctg gcc 16 Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu Ala 310 315 320 ctt gct act aca atg tat tct cct ggg ggt gtc agt cag gtt gtt cag 1666 Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val Val Gln 325 330 335 aat gaa gaa aat gaa aac tgt ttg aag aaa gtg gat ccc cag cta ttg 1714 Asn Glu Glu Asn Glu Asn Cys Leu Lys Lys Val Asp Pro Gln Leu Leu 340 345 350 aag atg gca tta act cct tac ccc aag cta aaa act gct ctc ttc cca 1762 Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr Ala Leu Phe Pro 355 360 365 370 cag tgc act cct cct agt gtc ctg cca tct gat att aca atc tac cac 1810 Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp Ile Thr Ile Tyr His 375 380 385 ctt att cag gta cag tat tta ggt ggc caa tat tta ggt cta tca gag 1858 Leu Ile Gln Val Gln Tyr Leu Gly Gly Gln Tyr Leu Gly Leu Ser Glu 390 395 400 ttc agc cag gaa aac aga aat cac tct aga tct ttc aac cgg agg gca 1906 Phe Ser Gln Glu Asn Arg Asn His Ser Arg Ser Phe Asn Arg Arg Ala 405 410 415 ttt aat gta ggg aat tac tta cac agc atg ata atca tgg gga aac 1954 Phe Asn Val Gly Asn Tyr Leu His Ser Met Ile Ala Glu Trp Gly Asn 420 425 430 caa atg tgatagtgag acaacccaaa aataacaaaa tagaaagcca tcatcacccc 2010 Gln Met 435 taaggctgca agaacaatgc aaaaaagtgg tgttaccaga acccagaagc tggagccatc 2070 tctgggagtt aaactaacaa ccaggctgcc taatgggaac caggaacata gagtatagag 2130 gtagaaactt agcggagatg ccccaggaaa atgaaggggg agaatatctt ggcttcttcc 2190 ctcttcccat ctttagtctc ccacagtgtc tttgtggcta tatgtatctg gtagccgaag 2250 ggcaaaggag cttgggaaat gtagtatcct gcaatactga gcagagtggg aagggtggag 2310 gtgggtcaga ccaaacagtt gaccagcata cctgtctgct gttttcatca aaagcttctc 2370 tattctgcca cttttaactt ctaactatct cttctcaatg aatcagggat gtttgtttaa 2430 atcagtgctt tttaatcttt ttcagaacgt ctaagaatgt gagaaagcta taaaccttct 2490 actcagaaaa attacacata tgcatataat tttgcttaca tttcaaagtg attcacagac 2550 ttcctgaagc ctattcaggg atcctcggtt aagaacacct tcctttgccc atttctcatt 2610 tcaaaaggct tttccttttt tccctgaata cacatattct catagtatct tcaactcaac 2670 gtaaggttta taattctata aaggagccgg gtgcagtggc tcatgcctgt aatcccagca 2730 ctttgggagg ccaaggtggg cgggtcactg agttcaagac ctagccaaca tagtgaaacc 2790 ccatctctac tgaaaatata acaattagcc aggcatggtg gcacgtgcct gtagtcccag 2850 ctactctgga ggccgaggta ggagaatggc ttgaacctgg gaggcgaaag ttgcagtaag 2910 ctgagatcgc accattgcac tctagcctgg gcaacagagc gagaccccgt ctcaaaaaaa 2970 ataataactc tataaaggca caaactccct cttactctaa tgcagagact tcttagggta 3030 ttgactggtg ctact taaaa gtgtggtcag cacttgtata ctgcttgttg ctggaacgtg 3090 gtgagattag tatgcaccaa aatatatatc tgctgtgtcc ctaagtacac tgtttagttc 3150 agtaggggtt tttttgtagc aagactttga agaaggaagc agtattctgg atttatactg 3210 acagaagtgt cttaccttgt tttagaccag cactttgagt agcactggta taaatgataa 3270 agtggattat gtaaaaacat agttttactg ggaaagtaca ggtcacagat gcccctgtgt 3330 cttgtttttt cccaggcaaa acaaacatag tttcactacg taaagtagtt tggatcagct 3390 tgaaacacaa gtggtttcat gttgctcttt gttctgtttt caagtggact gatttaattt 3450 ttttagtggt tattttagga aaagtattcc ttctttaata gatcacaaaa tcttccttag 3510 ttttacatca aagctactct attttgggcc atccaaatcc tgactttttt tgttctgttt 3570 ttttcctgta tttttcccac gatccgttta tagactttgc taaacatttg gcctagaaaa 3630 attccaaaca accactactt gctgctgcca gatcttttct gattgacttc accttggtcc 3690 gctatttttt ctttgttgtt catgttgttg ctcatcacat tccttcaacc atttatctag 3750 ttttttcttc tcttttcctt tccttgccta ccctgttctt tgctcatctt atcatgttta 3810 cctggtaacg ttttctagtc ttttagccct cttgcttttt gattccaaaa gcatttctga 3870 agcccatttt actttatagt tgatgctccc tctaccaaaa gagtatagcc tttgcggaca 3930 tagtttgaca taaggagagt ctttaaaagg aacatagcca gttctgtttt aattaagata 3990 taaagatatg tcataattct attttatttt tagctgtgtt caaagaattt atgtccagaa 4050 taagccttaa attgccttgg aaaaggggag cagactacct ctgaagtcct ttcatataat 4110 tttttttacc tattttataa tcagtgaact tctaattctg tttaactttt cccctttttc 4170 agtcattatc accctttgat cctagcagat tgtttggctg gcagtctgct aacacactag 4230 ctataggagg aatcaggtca caatgtgaaa agtccttgga attccatgag aaaacacaac 4290 tttatttcag aaataagctt tgaactttga aaacaagagc aggtacactg ttttccagaa 4350 ctagtttctg gaaccagatc acagtgttgt cttttttaaa aaataggtag taagtggtta 4410 agagacaatt gaatagtacg tgacaggagt gactatttct ttctaactgg agtcagccct 4470 ccatatcctt gggatccaca tccaaggatt caaccaacct cagatgggaa atattcaaaa 4530 gaacaaacaa acaatttaaa aaaaagaaaa acaatagaac aattaaaaat aataccaatt 4590 taaaaataca gtataacaac tatctacatg gcatttacat ttattgggta ttataagtga 4650 tctagagtaa tctaaagtgt atggggaaat gtgcataggc tatatataaa tactatgcta 4710 ttttacaggg acttgagcat ccttc tgtgg attttggtat ccaagggttt caggaaccaa 4770 tcccccatgg ataccaagag atgactagac tcatatcaaa atatcttctg acttcaaatt 4830 tatctaaaaa aagacatttt tgtttgatat tttcttgggt ttagaggaac tttaaactga 4890 gctattctgc tggtcttatt aatagaagga tggtgccatc tttctaagat attcatgctc 4950 tatgaataca acatcagaaa gtaagtgata acaaatggag gttataggag ggtaattagt 5010 gtagagggaa aaatgttcta aaattacctg ttggaggcca ggtgcagtgg ctcatgcctg 5070 taatcctaac actcaggaag ctgaggtgga aggattgctt gaggcgagga attcaagacc 5130 agcttggaca acatagcaag acactgtctc tacaaaaaat tagccgggta tagaagataa 5190 gggtcaagaa ggtgaaagaa aaatgttaaa attagccagg catagttgtg tgtgcctaca 5250 gtgctacagg aggctgaggc aagaggattg cttgagttaa ggaagtcaag gctgcagtgca tcc gagcacct gccatcctcagcc gccatcctcagcccagcc <210> 26 <211> 5814 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (7) .. (2880) <400> 26 gcgtga ggc cga ggg agg ggc ggc ggc gcg agc ggc ggc ggc ggc ggt 48 Gly Arg Gly Arg Gly Gly Gly Ala Ser Gly Gly Gly Gly Gly 1 5 10 tcc agc atg aag agg aga gc gg gc gg cg agg tca gtg 96 Ser Ser Met Lys Arg Arg Ala Gly Leu Gly Gly Ser Met Arg Ser Val 15 20 25 30 gtg ggc ttc ttg tcc cag cgg ggc ttg cat ggg gac ccc ctg ctc act 144 Val Gly Phe Leu Ser Gln Arg Gly Leu His Gly Asp Pro Leu Leu Thr 35 40 45 cag gac ttt cag agg aga cgc ctg cgg ggc tgc aga aac ctc tac aag 192 Gln Asp Phe Gln Arg Arg Arg Leu Arg Gly Cys Arg Asn Leu Tyr Lys 50 55 60 aag gac ctc ctc ggc cac ttc ggc tgt gtc aat gcc att gaa ttc tcc 240 Lys Asp Leu Leu Gly His Phe Gly Cys Val Asn Ala Ile Glu Phe Ser 65 70 75 aac aat gga ggc cag tgg ctg gtc tca gga gga gat gac cgcg g Asn Gly Gly Gln Trp Leu Val Ser Gly Gly Asp Asp Arg Arg Val 80 85 90 ctg cta tgg cac atg gaa caa gcc atc cac tcc agg gtc aag ccc ata 336 Leu Leu Trp His Met Glu Gln Ala Ile His Ser Arg Val Lys Pro Ile 95 100 105 110 cag ctg aaa gga gag cac cat tcc aac att ttt tgc ctg gct ttc aac 384 Gln Leu Lys Gly Glu His His Ser Asn Ile Phe Cys Leu Ala Phe Asn 115 120 125 agt ggg aac act aaa gtg ttc tct gga ggc aat gat gag caa gatc 432 Ser Gly Asn Thr Lys Val Phe Ser Gly Gly Asn Asp Glu Gln Val Ile 130 135 140 ctc cat gat gtt gaa agc agt gag aca ttg gac gtg ttt gct cat gaa 480 Leu His Asp Val Glu Ser Ser Glu Thr Leu Asp Val Phe Ala His Glu 145 150 155 gat gca gta tat ggc ttg tct gtg agc cca gtg aat gac aac att ttt 528 Asp Ala Val Tyr Gly Leu Ser Val Ser Pro Val Asn Asp Asn Ile Phe 160 165 170 gcc agt tcc tca gat gat ggc cgg gtt ctc att tgg gac att cgg gaa 576 Ala Ser Ser Ser Asp Asp Gly Arg Val Leu Ile Trp Asp Ile Arg Glu 175 180 185 190 tcc ccc cat gga gag ccc ttc tgc ctg gca aac tat cca tca gcc ttt 624 Ser Pro His Gly Glu Pro Phe Cys Leu Ala Asn Tyr Pro Ser Ala Phe 195 200 205 cat agt gtc atg ttt aac cct gtg gag ccc agg ttg ttg gcc aca gcc 672 His Ser Val Met Phe Asn Pro Val Glu Pro Arg Leu Leu Ala Thr Ala 210 215220 aat tca aag gaa gga gtg gga ctc tgg gac att cga aaa cct cag agt 720 Asn Ser Lys Glu Gly Val Gly Leu Trp Asp Ile Arg Lys Pro Gln Ser 225 230 235 tct ctc ctg cgc tat ggt gga aac ctg tccgt cca gcc atg agt 768 Ser Leu Leu Arg Tyr Gly Gly Asn Leu Ser Leu Gln Ser Ala Met Ser 240 245 250 gta cga ttc aac agc aac ggg acc cag ctc ctg gcc ctg agg cga cgc 816 Val Arg Phe Asn Ser Asn Gly Thr Gln Leu Leu Ala Leu Arg Arg Arg 255 260 265 270 ctg ccc cct gtg ctc tat gac atc cat tcc cgc ctg cct gtg ttt cag 864 Leu Pro Pro Val Leu Tyr Asp Ile His Ser Arg Leu Pro Val Phe Gln 275 280 285 ttt gac aat cag ggt tac ttc aac tca tgc acc atg aaa agc tgc tgt 912 Phe Asp Asn Gln Gly Tyr Phe Asn Ser Cys Thr Met Lys Ser Cys Cys 290 295 300 ttt gca gga gat cgt gac cag tat atc ctt tcg ggc tct gat gactt Ala Gly Asp Arg Asp Gln Tyr Ile Leu Ser Gly Ser Asp Asp Phe 305 310 315 aac ctg tac atg tgg aga att cct gca gat cca gaa gca ggt ggc att 1008 Asn Leu Tyr Met Trp Arg Ile Pro Ala Asp Pro Glu Ala Gly Ile 320 325 330 ggt agg gtg gtc aac gga gcc ttc atg gtg ctg aaa ggg cat cga tct 1056 Gly Arg Val Val Asn Gly Ala Phe Met Val Leu Lys Gly His Arg Ser 335 340 345 345 350 att gtt aac caa gtc cga ttt aatcc cac acc tac atg atc tgc tct 1104 Ile Val Asn Gln Val Arg Phe Asn Pro His Thr Tyr Met Ile Cys Ser 355 360 365 tct ggt gta gaa aag att atc aag atc tgg agc cca tac aag cag cca 1152 Ser Gly Val Glu Lys Ile Ile Lys Ile Trp Ser Pro Tyr Lys Gln Pro 370 375 380 gga tgt act gga gac ctc gac ggt cgg att gag gac gat tcc cgc tgc 1200 Gly Cys Thr Gly Asp Leu Asp Gly Arg Ile Glu Asp Asp Ser Arg Cys 385 390 395 ctc tat acc cat gaa gag tac atc agc ctt gtg ctg aac agt ggg agt 1248 Leu Tyr Thr His Glu Glu Tyr Ile Ser Leu Val Leu Asn Ser Gly Ser 400 405 410 ggc ctg tcg cat gac tac gcc aac cag tcg gtc cag gac gc cgg 1296 Gly Leu Ser His Asp Tyr Ala Asn Gln Ser Val Gln Glu Asp Pro Arg 415 420 425 430 atg atg gcc ttc ttt gac tca ctg gta cgc cga gag atc gag ggc tgg 1344 Met Met Ala Phe Phe Asp Ser Leu Val Arg Arg Glu Ile Glu Gly Trp 435 440 445 agc tct gac tca gac agt gac ctc agt gag agt act atc ctc caa ctg 1392 Ser Ser Asp Ser Asp Ser Asp Leu Ser Glu Ser Thr Ile Leu Gln Leu 450 455 460 cac gct ggg gtc agc gag cgc tca ggc tac act gac tca gag tct tcg 1440 His Ala Gly Val Ser Glu Arg Ser Gly Tyr Thr Asp Ser Glu Ser Ser 465 470 475 gcc tca ttg cct cgc tcc ccg cct ccc aca gta gat gag tct gcc gac 1488 Ala Ser Leu Pro Arg Ser Pro Pro Pro Thr Val Asp Glu Ser Ala Asp 480 485 490 aac gcc ttc cac ctg ggg ccc ctg cgg gtc acc acc aca aac aca gta 1536 Asn Ala Phe His Leu Gly Pro Leu Arg Val Thr Thr Thr Thr Asn Thr Val 495 500 505 510 gcc tca act cca cca aca ccc acg tgt gag gat gca gcc tct cgc cag 1584 Ala Ser Thr Pro Pro Thr Pro Thr Cys Glu Asp Ala Ala Ser Arg Gln 515 520 525 cag cgt ctg tct gct ctg cgg cgc tac caa gac aaa cgc ctc ctg gcc 1632 Gln Arg Leu Ser Ala Leu Arg Arg Tyr Gln Asp Lys Arg Leu Leu Ala 530 535 540 ctt tcc aat gag tcc gat tct gag gag aat gtc tgt gag gtg gaa cta 1680luu Sern Ser Asp Ser Glu Glu Asn Val Cys Glu Val Glu Leu 545 550 555 gac aca gat ctc ttt ccc cgg cca cgg tca ccc agc ccc gaa gat gaa 1728 Asp Thr Asp Leu Phe Pro Arg Pro Arg Ser Pro Ser Pro Glu Asp Glu 560 565 570 tcc agc agt tcc agc agc tct agc agc tct gag gat gag gag gag ctg 1776 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Asp Glu Glu Glu Glu Leu 575 580 585 585 590 aat gaa cgc cga gcc tct acc tgg cag cgg aat gcc atg cgg cgc cga 1824 Asn Glu Arg Arg Ala Ser Thr Trp Gln Arg Asn Ala Met Arg Arg Arg 595 600 605 cag aag aca acc cga gaa gac aag ccc agt gcc cca atc aag ccc acc 1872 Gln Lys Thr Thr Arg Glu Asp Lys Pro Ser Ala Pro Ile Lys Pro Thr 610 615 620 aac act tac att gga gaa gac aac tat gat tac ccc cag atc aaa gtg 1920 Asn Thr Tyr Ile Gly Glu Asp Asn Tyr Asp Tyr Pro Gln Ile Lys Val 625 630 635 635 gat gac ctc tcc tcc tcc cca acc tcg tcc cct gag cgg agc act tcc 1968 Asp Asp Leu Ser Ser Ser Pro Thr Ser Ser Pro Glu Arg Ser Thr Ser 640 645 650 acg cta gag att caa cca agc cgg gca tca cca act tct gac ata gaa 20 16 Thr Leu Glu Ile Gln Pro Ser Arg Ala Ser Pro Thr Ser Asp Ile Glu 655 660 665 670 tca gtt gag cga aaa att tat aaa gct tac aag tgg ctc cgc tac tct 2064 Ser Val Glu Arg Lys Ile Tyr Lys Ala Tyr Lys Trp Leu Arg Tyr Ser 675 680 685 tat atc tcc tac tca aat aac aaa gat gga gag acc tcc ttg gtg act 2112 Tyr Ile Ser Tyr Ser Asn Asn Lys Asp Gly Glu Thr Ser Leu Val Thr 690 695 700 ggg gag gca gat gaa ggg aga gca gga acc agc cac aaa gac aac cca 2160 Gly Glu Ala Asp Glu Gly Arg Ala Gly Thr Ser His Lys Asp Asn Pro 705 710 715 gcc cct tct tcc agt aag gaa gcc tgt cta aac ata gca atg gcc cag 2208 Ala Pro Ser Ser Ser Lys Glu Ala Cys Leu Asn Ile Ala Met Ala Gln 720 725 730 agg aac cag gac ctg cca cct gaa ggc tgc agc aag gac act ttt aaa 2256 Arg Asn Gln Asp Leu Pro Pro Glu Gly Cys Ser Lys Asp Thr Phe Lys 740 745 750 gaa gag act cct aga act ccc agc aat ggc cca ggc cat gag cac agc 2304 Glu Glu Thr Pro Arg Thr Pro Ser Asn Gly Pro Gly His Glu His Ser 755 760 765 agc cat gct tgg gca gag gtg cca gag ggt ac c tct cag gac act ggc 2352 Ser His Ala Trp Ala Glu Val Pro Glu Gly Thr Ser Gln Asp Thr Gly 770 775 780 aat agc ggc tct gta gag cac cct ttt gaa acc aag aag ctc aat gga 2400 Asn Ser Gly Ser Val Glu His Pro Phe Glu Thr Lys Lys Leu Asn Gly 785 790 795 aag gcc ctg agc agt cgg gct gag gag ccg cct tct cct cct gtc ccc 2448 Lys Ala Leu Ser Ser Arg Ala Glu Glu Pro Pro Ser Pro Pro Val Pro 800 805 810 aag gca tct ggc tcc act ctc aac agc ggg tct ggc aac tgt ccc agg 2496 Lys Ala Ser Gly Ser Thr Leu Asn Ser Gly Ser Gly Asn Cys Pro Arg 815 820 825 830 acc cag tct gat gac agt gag gag agg agc ctc gaa acc atcgt gcc 2544 Thr Gln Ser Asp Asp Ser Glu Glu Arg Ser Leu Glu Thr Ile Cys Ala 835 840 845 aac cac aac aat gga cgc tta cac cct cgt ccc cct cac cct cac aat 2592 Asn His Asn Asn Gly Arg Leu His Pro Arg Pro Pro His Pro His Asn 850 855 860 aac ggg cag aac ttg ggg gag ctg gag gtg gtg gcc tac tct tcc cca 2640 Asn Gly Gln Asn Leu Gly Glu Leu Glu Val Val Ala Tyr Ser Ser Pro 865 870 875 gga cac tca gac act gac cgt gat aac tcg tcc ctg aca ggg aca ctc 2688 Gly His Ser Asp Thr Asp Arg Asp Asn Ser Ser Leu Thr Gly Thr Leu 880 885 890 cta cac aaa gat tgt tgc ggg tct gaa atg gcc tgt gag acc ccc aat 2736 Leu His Lys Asp Cys Cys Gly Ser Glu Met Ala Cys Glu Thr Pro Asn 895 900 905 910 gct gga aca aga gag gac ccc act gac acc cca gcc aca gat agt agc 2784 Ala Gly Thr Arg Glu Asp Pro Thr Asp Thr Pro Ala Thr Asp Ser Ser 915 920 925 agg gct gtt cat ggc cac agt ggc ctc aaa agg caa cga att gaa ttg 2832 Arg Ala Val His Gly His Ser Gly Leu Lys Arg Gln Arg Ile Glu Leu 930 935 940 gaa gat aca gat tca gag aat tcc tcc aag aaa tta aaa aca 2880 Glu Asp Thr Asp Ser Glu Asn Ser Ser Ser Glu Lys Lys Leu Lys Thr 945 950 955 tgataaatac aaagggaaaa caaaaagcta caaaagtagc cttacaaaaa aaaaaaattg 2940 tttagtgaat acagaggaaa ggaaaaacaa gtattaaagg cacatgaaac cagggcctga 3000 aattttgtgt ctgatgctgc tcccttctat ccaacattca acaacgggtc tgaatgtcta 3060 gctggccatt ggcttgtgct gtgttaagaa aggggaaaaa aaaataaccc aagtgactcc 3120 tttctagtga gacgtgagcg tagtgtgccg cgcaaggctc tgtggaagta aatctttgtt 3180 gagacgttcg acttgttctt gtgtacgcac aatggcacgt gtgcgcttat tgtctcataa 3240 gaccttcctt ttagttctcc atcagaaagg acctatgaat ttgtactttt tgccatctca 3300 ccctgtttac atgccatagg tgttctggtc tggatgatgg gtgcctgtta aatcaggttg 3360 tgctgccagt gagttgtaga tttatgctgg aagaatggag aatggaaaca ggccttcagc 3420 ccattggctg cgctggagag gaaagcatgg ttcctttctt aaagaaatct tccatgtttt 3480 ctctaagtaa cacttcttta ttgagcattt aatgtggaca tactataaaa aagaattttt 3540 aatgctaatg agaggtttag cacttaagat cagattcaag agaatataga ttcctgataa 3600 atttcactgt ttgcaaattg agcagtgctg caacatgtac tgtatgaagg ccataaaata 3660 gagctagtca tggataacag actttaacca gttaggtgct agatcctaag aggcactcac 3720 aaggccagca ggtgcttcct tggctcccat gatcgatcga ggcatagtga aagaagggca 3780 aagacagctt tccagagctt tgtgctcagg ctactaaagt agttgttata ggtgtgttaa 3840 cgaagaagct tagtgaggag cagaatgtgg tactatattc atttaactca acccagaacc 3900 attggtcaga attggtggga ctggcatctt ccctcagact tgcagttgat agaggctgtg 3960 gtgttctcac tagac tttgc agagcagtag gcatctcaag gtaacagatt cttattgagt 4020 aggtctatta ggagtcagaa ggtgttgggg aggagtctct ggcttatgac tcctggttcc 4080 cattagtctt aagtcttctg gttcccataa aagactcagt tttattgagg tagatacagg 4140 tttagaagag aaaagagcaa cagattttca gcgttgcagt cactcggtta tctatgaagg 4200 gttgtgcaaa acaggaaggt ctgggaatga ccagatatct tgttggcata aatgttatga 4260 aaaggcagaa tactggcaag aaatgaggaa gagagagaaa aacaatataa ctttcttgag 4320 tgcaaaggtg ctagacaact aggagcccag ctgggattgg tgtagggagg gccgaacgct 4380 gactagtgtg gcctcactgc cccaggcttc ctttcagagg aaggcctgtc ctgctggaac 4440 tggagccaag gggaggctgc ctatgaaggc agaagatgtg gatgaattca ggcactgggg 4500 gtgggggggt tatttataaa cacaaggtgg ttggtttaag ccaaaaggag ataccatcct 4560 gataagctct gtgaaagaga agatgtgcct ggtgtgtgta atgcggctgg ggtatgaaaa 4620 cactgagaag gagatgaagg agtgtgtgta gcatgggggt gtgtacaact taacacctgg 4680 acttttactg ggggagtggg aaagtgattc tgtaaccaac attagaatta ctttggattt 4740 gtaatcagat tggttctatg atttgtcttt gactattcac agataattgt aaatgctggt 4800 tttataagcc caagtcattt tacatttgct tttccaaaat gtattaaatt ggaatttttt 4860 taatccttta tatacaaaaa aatacgatca ctcagtgtgt gtttctcttc cccttcttag 4920 tcagcacacc cagtccttta ttttattcta ttctatttat tttattttaa taagtactta 4980 gcctcttctg acttctcaaa ggacaatcgg atacatatct tcctgaaaag aagtagttaa 5040 agttcccttg ggaactagct acttggtagt tacaattccc aaatgcagaa cttggtcttt 5100 tcatgttaaa agccttaatc tcatttgggt actcaaaaga gaaatcagag tttattctgg 5160 ttaacttgag aagccaagaa agatcatttt tagcaagtat gccttccatc cttggcagag 5220 gcttcccagc atcctaggct cagcttaccg ggtgataggc cccataagac acacacatga 5280 gcagggtgag aaatgcttgc tttatagctg ctccaccctc atctccagag attttgtgtc 5340 tatggttgtg ggtctggaaa cctggcagga accacttcta gagtaccttt gcctaaactc 5400 ttttagaatt gaggccccaa ctttgatggc acatttaata cccaatttct tccataatag 5460 atatttttaa tagcaggaca gatggcactg attagatcaa gaactatttg gaagtgcctc 5520 ttatgttttt ttcctgcatt ctgtacataa agttttaagt ggcaggtcca gatatgtaaa 5580 atcatttctc tctattttcc agctggtttt gttaatgatt ctctaggaca gcaggtaaat 5640 gagttaagtt gttggcttgg ggcaag tgaa gtttgtgact atgcttgatt taataagctg 5700 agagtctctt gtttgtctgt caaggtgcct tcctctgctg aagccttacc tccttctcac 5760 ccagtaacgg ttaactcttc tcttgtgtgtat atgcaaataa acctattatt cact 5814 <210> 27 <211> 5779 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (4958) <400> 27 gt gac cct gaa gaa cag ctt tca gaa aat gcc tgc atc tct gaa acg 47 Asp Pro Glu Glu Gln Leu Ser Glu Asn Ala Cys Ile Ser Glu Thr 1 5 10 15 tcc ttt tct tct gag agc cca gag gga gcc tgt acc agc ctg cct tct 95 Ser Phe Ser Ser Glu Ser Pro Glu Gly Ala Cys Thr Ser Leu Pro Ser 20 25 30 cca gga ggg gaa aca cag tcc aca tca gaa gaa tca tgt act cca gcc 143 Pro Gly Gly Glu Thr Gln Ser Thr Ser Glu Glu Ser Cys Thr Pro Ala 35 40 45 tcc ctt gag aca aca ttt tgt tct gag gta tct agc act gaa aat aca 191 Ser Leu Glu Thr Thr Phe Cys Ser Glu Val Ser Ser Thr Glu Asn Thr 50 55 60 gac aaa tac aac cag aga aat tcc act gat gaa aac ttt cat gca tct 239 Asp Lys Tyr Asn Gln Arg Asn Ser Thr Asp Glu Asn Phe His Ala Ser 65 70 75 ttg atg tca gaa ata tct cca ata tcc act tca cct gaa ata tca gaa 287 Leu Met Ser Glu Ile Ser Pro Ile Ser Thr Ser Pro Glu Ile Ser Glu 80 85 90 95 gca tct ctt atg tcc aac tta cca tta aca tct gaa gca tca cca gta 335 Ala Ser Leu Met Ser Asn Leu Pro Leu Thr Ser Glu Ala Ser Pro Val 100 105 110 tcc aac tta cct tta aca tca gaa acc tca ccg atg tct gac tta cct 383 Ser Asn Leu Pro Leu Thr Ser Glu Thr Ser Pro Met Ser Asp Leu Pro 115 120 125 tta aca tca gaa act tct tca gtg tct tcc atg ctt ctc acc tct gag 431 Leu Thr Ser Glu Thr Ser Ser Val Ser Ser Met Leu Leu Thr Ser Glu 130 135 140 acc act ttt gta tcc agt ttg cca ctt cct tca gaa aca tct cca att 479 Thr Thr Phe Val Ser Ser Leu Pro Leu Pro Ser Glu Thr Ser Pro Ile 145 150 155 tcc aac tct tcc ata aat gag aga atg gca cat cag caa aga aag tca 527 Ser Asn Ser Ser Ile Asn Glu Arg Met Ala His Gln Gln Arg Lys Ser 160 165 170 175 cct tct gta tct gaa gag cca ctc tcc ccg cag aaa gat gag tct tcc 575 Pro Ser Val Ser Glu Glu Pro Leu Ser Pro Gln Lys Asp Glu Ser Ser 180 185 190 gcc act gcc aaa cct ctg gga gag aac ctt acc tcc cag cag aag aat 623 Ala Thr Ala Lys Pro Leu Gly Glu Glu Asn Leu Thr Ser Gln Gln Lys Asn 195 200 205 ctg tct aat act ccc gaa ccc atc ata atg agt tct tct tcc att gct 671 Leu Ser Asn Thr Pro Glu Pro Ile Ile Met Ser Ser Ser Ser Ile Ala 210215 220 cct gaa gca ttt ccg tct gaa gat ttg cac aat aag acc ctg agt cag 719 Pro Glu Ala Phe Pro Ser Glu Asp Leu His Asn Lys Thr Leu Ser Gln 225 230 235 caa acc tgt aaa tca cat gtt gac act gag aag ccc tac cct gct tca 767 Gln Thr Cys Lys Ser His Val Asp Thr Glu Lys Pro Tyr Pro Ala Ser 240 245 250 255 att cca gaa ctt gct tct act gaa atg ata aaa gtt aaa aat cat agc 815 Ile Pro Glu Leu Ala Ser Thr Glu Met Ile Lys Val Lys Asn His Ser 260 265 270 gtc ctg caa aga aca gaa aaa aaa gtg tta cct tca cca ttg gaa tta 863 Val Leu Gln Arg Thr Glu Lys Lys Val Leu Pro Ser Pro Leu Glu Leu 275 280 285 tct gtc ttt tct gaa ggg aca gat aat aag gga aat gag ctt cca tct 911 Ser Val Phe Ser Glu Gly Thr Asp Asn Lys Gly Asn Glu Leu Pro Ser 290 295 300 gct aaa tta cag gac aag caa tat atc tca tca gtg gat aag gct cca 959 Ala Lys Leu Gln Asp Lys Gln Tyr Ile Ser Ser Val Asp Lys Ala Pro 305 310 315 ttt tca gaa ggc tct aga aat aaa aca cat aag caa ggg agt aca cag 1007 Phe Ser Glu Gly Ser Arg Asn Lys Thr His Lys Gln Gly Se r Thr Gln 320 325 330 335 agt cgg tta gaa acc tca cat act tcc aag tca tca gag ccc tcc aag 1055 Ser Arg Leu Glu Thr Ser His Thr Ser Lys Ser Ser Glu Pro Ser Lys 340 345 350 tca cct gat ggg ata aga agt gaa agt aga gat tca gag ata tca aag 1103 Ser Pro Asp Gly Ile Arg Ser Glu Ser Arg Asp Ser Glu Ile Ser Lys 355 360 365 aga aaa act gca gag caa cac agc ttt gga atc tgt aag gaa aag aga 1151 Arg Lys Thr Ala Glu Gln His Ser Phe Gly Ile Cys Lys Glu Lys Arg 370 375 380 gct agg ata gaa gat gat cag tca acc cgg aac ata tca tct agc agc 1199 Ala Arg Ile Glu Asp Asp Gln Ser Thr Arg Asn Ile Ser Ser Ser Ser 385 390 395 cca cct gag aaa gaa cag cct ccc aga gag gaa cca agg gtt ccc cct 1247 Pro Pro Glu Lys Glu Gln Pro Pro Arg Glu Glu Pro Arg Val Pro Pro 400 405 410 415 ctc aag att cag ctt tcc aaa att ggg cca cct ttt ata atc aag agc 1295 Leu Lys Ile Gln Leu Ser Lys Ile Gly Pro Pro Phe Ile Lys Ser 420 425 430 caa cca gtc tcc aaa cct gag tct cga gca tcc act agc aca tct gtc 1343 Gln Pro Val Ser Lys Pro Glu Ser Arg Ala Ser Thr Ser Thr Ser Val 435 440 445 agt ggc ggg agg aac aca gga gcc agg acc ctc gca gat atc aag gcc 1391 Ser Gly Gly Gly Arg Asn Thr Gly Ala Arg Thr Leu Ala Asp Ile Lys Ala 450 455 460 cgg gcc caa caa gct cgg gcc cag cga gag gct gct gca 1439 Arg Ala Gln Gln Ala Arg Ala Gln Arg Glu Ala Ala Ala Ala Ala Ala 465 470 475 gtg gct gct gca gcg agc att gtc tct gga gcc atg gag g Val Ala Ala Ala Ala Ser Ile Val Ser Gly Ala Met Gly Ser Pro Gly 480 485 490 495 gag ggt gga aag acg aga act ctg gca cac atc aaa gag cag aca aag 1535 Glu Gly Gly Lys Thr Arg Thr Leu Ala His Ile Lys Glu Gln Thr Lys 500 505 510 gct aag ctc ttt gca aag cat caa gct cga gcc cat ctc ttc cag acc 1583 Ala Lys Leu Phe Ala Lys His Gln Ala Arg Ala His Leu Phe Gln Thr 515 520 525 tct aaa gag acc cgg ttg cct cct ccg ctc agc tca aag gaa ggg cct 1631 Ser Lys Glu Thr Arg Leu Pro Pro Pro Leu Ser Ser Lys Glu Gly Pro 530 535 540 cca aac tta gaa gtc tct tct acc cct gaa aca aaa atg gaa ggt tcg 1679 Pro Asn Leu Glu Val Ser Ser Thr Pro Glu Thr Lys Met Glu Gly Ser 545 550 555 act ggt gtc att att gtc aat cca aac tgt aga tct cct agc aac aag 1727 Thr Gly Val Ile Ile Val Asn Pro Asn Cys Arg Ser Pro Ser Asn Lys 560 565 570 575 tct gcc cac ctc cgg gag acc acc act gta cta cag cag tct ctt aac 1775 Ser Ala His Leu Arg Glu Thr Thr Thr Val Leu Gln Gln Ser Leu Asn 580 585 590 cca agt aaa ctt cca gaa act gcc act gac tta tct gtg cat agt tct 1823 Pro Ser Lys Leu Pro Glu Thr Ala Thr Asp Leu Ser Val His Ser Ser 595 600 605 gat gaa aac ata cct gtg tca cat tta tct gag aaa att gtt tca tct 1871 Asp Glu Asn Ile Pro Val Ser His Leu Ser Glu Lys Ile Val Ser Ser 610 615 620 acc tct tct gaa aat agc agt gtg ccc atg ctt ttt aat aaa aat tct 1919 Thr Ser Ser Glu Asn Ser Ser Val Pro Met Leu Phe Asn Lys Asn Ser 625 630 635 635 gtc cct gta tct gtt tgc agc act gct ata tcg gga gca att aaa gaa 1967 Val Pro Val Ser Val Cys Ser Thr Ala Ile Ser Gly Ala Ile Lys Glu 640 645 650 655 cat ccc ttt gtg agt tct gtt gat aaa tcc tct gtc cta atg tc t gtt 2015 His Pro Phe Val Ser Ser Val Asp Lys Ser Ser Val Leu Met Ser Val 660 665 670 gac agt gca aac act aca att tct gct tgt aat ata agc atg tta aaa 2063 Asp Ser Ala Asn Thr Thr Ile Ser Ala Cys Asn Ile Ser Met Leu Lys 675 680 685 acc atc cag gga act gac act cca tgc ata gcc att ata cca aaa tgt 2111 Thr Ile Gln Gly Thr Asp Thr Pro Cys Ile Ala Ile Ile Pro Lys Cys 690 695 700 att gaa agc act ccc att tca gcc act aca gag ggc tcc agc ata tca 2159 Ile Glu Ser Thr Pro Ile Ser Ala Thr Thr Glu Gly Ser Ser Ile Ser 705 710 715 agc tcc atg gat gat aag cag tta cta ata tca agc agc agt gct agt 2207 Ser Ser Met Asp Asp Lys Gln Leu Leu Ile Ser Ser Ser Ser Ala Ser 720 725 730 735 aac tta gtc tcc act cag tac acc tct gtg cca act ccc tcc atc gga 2255 Asn Leu Val Ser Thr Gln Tyr Thr Ser Val Pro Thr Pro Ser Ile Gly 740 745 750 aac aat ttg cca aac ctc tcc act agc tct gtc ttg att ccc cca atg 2303 Asn Asn Leu Pro Asn Leu Ser Thr Ser Ser Val Leu Ile Pro Pro Met 755 760 765 gga att aac aac aga ttt cct tct gag aa g ata gcc ata cct ggg agt 2351 Gly Ile Asn Asn Arg Phe Pro Ser Glu Lys Ile Ala Ile Pro Gly Ser 770 775 780 gaa gaa cag gcc act gta tcc atg ggt acc act gtg aga gca gcc ctc 2399 Glu Glu Gln Ala Thr Val Ser Met Gly Thr Thr Val Valg Ala Ala Leu 785 790 790 agc tgc agt gat tct gta gcg gtc aca gac tct ctg gtt gca cac ccg 2447 Ser Cys Ser Asp Ser Val Ala Val Thr Asp Ser Leu Val Ala His Pro 800 805 810 810 815 acc gtc gca atg ttt act gga aac atg ctg aca ata aac tct tat gat 2495 Thr Val Ala Met Phe Thr Gly Asn Met Leu Thr Ile Asn Ser Tyr Asp 820 825 830 agt cct ccc aag tta agt gct gaa agc ttg gac aaa aatca ggg cct 2543 Ser Pro Pro Lys Leu Ser Ala Glu Ser Leu Asp Lys Asn Ser Gly Pro 835 840 845 cga aac agg gca gat aat tct gga aaa cct cag caa cca cca ggg ggc 2591 Arg Asn Arg Ala Asp Asn Ser Gly Lys Pro Gln Gln Pro Pro Gly Gly 850 855 860 ttt gca cca gca gcc ata aac cga tca att ccg tgt aaa gtc atc gtt 2639 Phe Ala Pro Ala Ala Ile Asn Arg Ser Ile Pro Cys Lys Val Ile Val 865 870 875 gac cac agc acc acg ctg acc tcc agt ttg tct ctg act gtc tcc gtt 2687 Asp His Ser Thr Thr Leu Thr Ser Ser Leu Ser Leu Thr Val Ser Val 880 885 890 895 gaa agc tca gaa gcc agc ttg gac ctg cag ggc aga cca gtg agg aca 2735 Glu Ser Ser Glu Ala Ser Leu Asp Leu Gln Gly Arg Pro Val Arg Thr 900 905 910 gag gca tcc gta cag ccc gtg gcg tgt cct cag gtg tct gtg att agc 2783 Glu Ala Ser Val Gln Pro Val Ala Cys Pro Gln Val Ser Val Ile Ser 915 920 925 agg cct gag cca gtt gcc aac gaa ggt ata gat cac agt tcc act ttc 2831 Arg Pro Glu Pro Val Ala Asn Glu Gly Ile Asp His Ser Ser Thr Phe 930 935 940 att gct gct tcg gca gca aaa caa gac agt aaa aca ttg ccg gcc acc 2879 Ile Ala Ala Ser Ala Ala Lys Gln Asp Ser Lys Thr Leu Pro Ala Thr 945 950 955 tgc aca agt ctc cga gaa tta ccc ctt gtt cca gat aaa tta aat gag 2927 Cys Thr Ser Leu Arg Glu Le Pro Leu Val Pro Asp Lys Leu Asn Glu 960 965 970 975 ccg act gct ccc agt cat aac ttt gct gag cag gca cgt ggc cca gct 2975 Pro Thr Ala Pro Ser His Asn Phe Ala Glu Gln Ala Arg Gly Pro Ala 980 985 990 cct ttc aaa agt gaa gca gac aca acc tgt agc aat cag tat aac cca 3023 Pro Phe Lys Ser Glu Ala Asp Thr Thr Cys Ser Asn Gln Tyr Asn Pro 995 1000 1005 agt aac cgg att tgc tgg aat gat gat ggg atg agg ag ag aca gga cag 3071 Ser Asn Arg Ile Cys Trp Asn Asp Asp Gly Met Arg Ser Thr Gly Gln 1010 1015 1020 cct ctg gtt act cac tcg ggt tca agt aaa caa aaa gaa tat cta gag 3119 Pro Leu Val Thr His Ser Gly Ser Ser Lys Gln Lys Glu Tyr Leu Glu 1025 1030 1035 caa agc tgt cca aag gct atc aaa act gaa cat gcc aac tac ttg aac 3167 Gln Ser Cys Pro Lys Ala Ile Lys Thr Glu His Ala Asn Tyr Leu Asn 1040 1045 1050 1055 gtg tca gaa cat ccc agg aat ctt gta aca aat gtt gct ctt cct 3215 Val Ser Glu Leu His Pro Arg Asn Leu Val Thr Asn Val Ala Leu Pro 1060 1065 1070 gtg aaa tct gaa ctt cac gaa gca gac aag ggc ttt aga atg gac act 3263 Val Lys Ser Glu Leu His Glu Ala Asp Lys Gly Phe Arg Met Asp Thr 1075 1080 1085 gaa gac ttc cct ggc cct gag ctg cct cct ccg gct gca gag gga gcc 3311 Glu Asp Phe Pro Gly Pro Glu Leu Pr o Pro Pro Ala Ala Glu Gly Ala 1090 1095 1100 tct agt gta caa caa aca cag aac gtg aaa gct tcc acc tca agt ccc 3359 Ser Ser Val Gln Gln Thr Gln Asn Val Lys Ala Ser Thr Ser Ser Pro 1105 1110 1115 atg gaa gag gct att tcc ttg gct acc gat gcc ctg aag aga gtc cct 3407 Met Glu Glu Ala Ile Ser Leu Ala Thr Asp Ala Leu Lys Arg Val Pro 1120 1125 1130 1135 ggt gca ggg agc tca ggc tgt cgt ctg tcc tct gtg gag gct 3455 Gly Ala Gly Ser Ser Gly Cys Arg Leu Ser Ser Val Glu Ala Asn Asn 1140 1145 1150 ccg ctg gtg acg cag tta cta cag ggc aac ctg cct ttg gaa aaa gtg 3503 Pro Leu Val Thr Gln Leu Leu Gln Gly Asn Leu Pro Glu Lys Val 1155 1160 1165 ttg cca cag ccc aga ttg gga gcc aag ctt gaa atc aac agg ctt cca 3551 Leu Pro Gln Pro Arg Leu Gly Ala Lys Leu Glu Ile Asn Arg Leu Pro 1170 1175 1180 ttg cct ctt caa act acc tca gt ggt aaa aca gca cca gag aga aac 3599 Leu Pro Leu Gln Thr Thr Ser Val Gly Lys Thr Ala Pro Glu Arg Asn 1185 1190 1195 gtt gaa att ccg ccc agc tct cca aat cca gat ggt aag ggc tac tt g 3647 Val Glu Ile Pro Pro Ser Ser Pro Asn Pro Asp Gly Lys Gly Tyr Leu 1200 1205 1210 1215 gca ggg act ctg gca cca ctc caa atg aga aag cga gaa aac cac ccc 3695 Ala Gly Thr Leu Ala Pro Leu Gln Met Arg Lys Arg Glu Asn His Pro 1220 1225 1230 aaa aag aga gta gct agg act gta gga gaa cac act caa gtt aaa tgt 3743 Lys Lys Arg Val Ala Arg Thr Val Gly Glu His Thr Gln Val Lys Cys 1235 1240 1245 gaa cca gga aaa ttg ttg ttg ttg gtg gag cca gat gtt aaa ggg gtg cct tgt 3791 Glu Pro Gly Lys Leu Leu Val Glu Pro Asp Val Lys Gly Val Pro Cys 1250 1255 1260 gtc atc agt tcc ggc atc agt cag cta gga cac agc cag cca ttt aag 3839 Val Ile Ser Ser Gly Ile Ser Gln Leu Gly His Ser Gln Pro Phe Lys 1265 1270 1275 caa gaa tgg cta aac aag cac tcc atg cag aac aga att gtt cac agc 3887 Gln Glu Trp Leu Asn Lys His Ser Met Gln Asn Arg Ile Val His Ser 1280 1285 1290 1295 cct gag gtc aaa cag caa aag cgg ctg ctc ccc tcg tgt agc ttc cag 3935 Pro Glu Val Lys Gln Gln Lys Arg Leu Leu Pro Ser Cys Ser Phe Gln 1300 1305 1310 cag aac cta ttt cat gtt gac aag aat ggc ggc ttc cac act gac gct 3983 Gln Asn Leu Phe His Val Asp Lys Asn Gly Gly Phe His Thr Asp Ala 1315 1320 1325 ggt acc tca cac aga cag cag ttt tac caa atg cct gtg gct gcc agg 4031 Gly Thr Ser His Arg Gln Gln Phe Tyr Gln Met Pro Val Ala Ala Arg 1330 1335 1340 ggc ccc att cct act gca gct ctg tta cag gcc tct tcc aag acc cca 4079 Gly Pro Ile Pro Thr Ala Ala Leu Leu Gln Ala Ser Ser Lys Thr Pro 1345 1350 1355 gtg ggg tgt aat gca ttt gcc ttc aac agg cat ctt gaa cag aag gga 4127 Val Gly Cys Asn Ala Phe Ala Phe Asn Arg His Leu Glu Gln Lys Gly 1360 1365 1370 1375 ttg gga gag gtt agt ctt tcc tca cct cac cag cta agg tta gcc 4175 Leu Gly Glu Val Ser Leu Ser Ser Ala Pro His Gln Leu Arg Leu Ala 1380 1385 1390 aac atg tta tcc ccc aat atg ccc atg aaa gaa ggt gat gag gtg gga 4223 Asn Met Leu Ser Pro Asn Met Pro Met Lys Glu Gly Asp Glu Val Gly 1395 1400 1405 ggc act gca cac aca atg cca aac aaa gca cta gta cat ccg ccg ccg 4271 Gly Thr Ala His Thr Met Pro Asn Lys Ala Leu Val His Pr o Pro Pro 1410 1415 1420 cca ccg cct ccc cct ccc cct cca ccc ttg gct ttg ccc ccg cct ccc 4319 Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Ala Leu Pro Pro Pro Pro 1425 1430 1435 ccc cca cca cct ccg cta cct cca cct ctc cct aat gca gaa gtc cca 4367 Pro Pro Pro Pro Pro Leu Pro Pro Pro Leu Pro Asn Ala Glu Val Pro 1440 1445 1450 1455 tct gat caa aaa caa cct cca gtt acc atg gaa acc act aag aga ctt 4415 Ser Asp Gln Lys Gln Pro Pro Val Thr Met Glu Thr Thr Lys Arg Leu 1460 1465 1470 agt tgg cca cag tcc acg ggc ata tgt agc aat ata aaa tcg gaa cct 4463 Ser Trp Pro Gln Ser Thr Gly Ile Cys Ser Asn Ile Lys Ser Glu Pro 1475 1480 1485 ctt tct ttt gag gaa ggt tta agc agc agc tgt gaa ctg ggc atg aaa 4511 Leu Ser Phe Glu Glu Gly Leu Ser Ser Ser Cys Glu Leu Gly Met Lys 1490 1495 1500 caa gtt tcc tat gac cag aat gaa atg tta aaa aaa gca ttc 4559 Gln Val Ser Tyr Asp Gln Asn Glu Met Lys Glu Gln Leu Lys Ala Phe 1505 1510 1515 gcg cta aaa agt gca gat ttc tct tcc tat ttg ctt tct gag cca caa 4607 Ala Leu Lys S er Ala Asp Phe Ser Ser Tyr Leu Leu Ser Glu Pro Gln 1520 1525 1530 1535 aag cct ttt acc caa tta gct gct cag aaa atg cag gtg cag caa caa 4655 Lys Pro Phe Thr Gln Leu Ala Ala Gln Lys Met Gln Val Gln Gln Gln 1540 1545 1550 cag cag ctc tgt gga aat tat cca aca ata cac ttt ggt agc acg agt 4703 Gln Gln Leu Cys Gly Asn Tyr Pro Thr Ile His Phe Gly Ser Thr Ser 1555 1560 1565 ttc aaa agg gca gca tct gca att gaaag tcc att ggg att ttg gga 4751 Phe Lys Arg Ala Ala Ser Ala Ile Glu Lys Ser Ile Gly Ile Leu Gly 1570 1575 1580 agt ggc tcc aat cct gcc aca ggc ttg tct ggt cag aac gct cag atg 4799 Ser Gly Ser Asn Pro Ala G Leu Ser Gly Gln Asn Ala Gln Met 1585 1590 1595 ccc gtt cag aac ttt gcc gac agc agc aat gca gat gaa ttg gaa ctg 4847 Pro Val Gln Asn Phe Ala Asp Ser Ser Asn Ala Asp Glu Leu Glu Leu 1600 1605 16g 1615 tct tgc cgg ctg aaa gcc atg att gtg tgc aaa ggc tgt ggg 4895 Lys Cys Ser Cys Arg Leu Lys Ala Met Ile Val Cys Lys Gly Cys Gly 1620 1625 1630 gcc ttc tgc cat gac gac tgc ata ggt cct tca aaa ctt tgt gta gca 4943 Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys Leu Cys Val Ala 1635 1640 1645 tgc ctg gtt gta cga taagagctga gtgaaagatg cagtatccct tttccacgg 4998 Cys Leu Val Valgcagca tcatccat gsg atttattttg ctttggagca ggtacctttc ctctatggca ttattttctt gcatttctca 5118 taaaggggag gatgcatccc aactgaatgg ctcactggca tgtcttttat gtgttcagtt 5178 gccattccta gctttggaaa gtttctatct gtccatgtgt atacaagtca atgccccatt 5238 tttgtttttc ttttaaccga ggtgtagata ggaaaaggac atttttaatt acttaataac 5298 cggaaatgca gatgtgtaag gagaatgaga ggaatgagtt aaagtggtta tgcatttttc 5358 tatagatgag ccattacagc aaggaatttt acagttgact tctctgaacc tagctttacc 5418 acagtgatta aatcctattt agaaagggga atctgattta aatgtgtgat tccttgtatt 5478 tgctcctatc acaaaagata tattaaagga ggtatgccat taatgaaatc cactgtcctg 5538 agtattatct ttcctcctgt tgtactttct cagagactat ggcagaatat ctggatcttc 5598 cttggatttt gtacacatat tgtagtgaaa tgtgtcctac atctgaaatt gcatgccg atctggttc taggcctttg acacctgata atatgagagc aattggccag 5718 ccaatagcca taagcccaga ggattttaga gcttcatgtg tggcttttaa gagcaggttt 5778 g 5779 <210> 28 <211> 5539 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4704) .. (4943) <400> 28 gtttttactg ggggtctgaa gacacaagtt ttattggagg tctaaatgaa ctcctcaaac 60 ctccgtgatt tagcaggaga tgtgataagg gtaatcaccc cagcacttgg acccatctag 120 attcaataca tttactgagg ctccagaaga aggtcttcac accttagtta tggattagaa 180 gaagttaatc acttacgtct ttagatgaat gcacacttac atgtagacat atggcttaga 240 aggtatataa accctggaaa gctttgtaat tttgagttag tctggtgata tattccaggc 300 cttctccctg tacccggtta caaaaataaa cttccttcct tcccagttca actgcatctt 360 gttattgggc cgcgagaatc agcagcctga ccctcggctt ggaccaggaa caacatggtc 420 tgagagagct catcccatgt tccaaaggga gattaaatga caaattaaga taccccaata 480 ataaaatgcc aacaataaga tgccctacag tgtaatagaa acaatgtacc attatgaaat 540 tcccagtagg aaatgaaagc tcaaagacta aattcacttg ccatttcaag ataaaaagaa 600 aatttcaggt ccaaactttt ttcctgcctc aatttcatat tctgatcagg ctcagccaga 660 ggatgtctca gtatttagac agagtggagg ttcctgcggc accatcctgg agaggtgtaa 720 cattctttgg gtggaaaagg tgaactctgc tctcatatgc tatctactta aagagtctgg 780 aattaatagg gcaccaaaga tgatcacagc tctgtctcca catccaccaa atttagaaac 840 caaatctgat aactaagtca tttatcagag actcagtggt acccaagtga ggaagggcca 900 ctggagacaa tcttgttttt ttcaccgggg ctggagtgca gtggcgcgat ctcggctcac 960 tgcaagcccc gcctcccggg ttcacgccat tctcctgcct cagcctcccg agtggcccgg 1020 actgtagggg cctgccacca tgtccagcta attttttgta tttttggtgg agacgaggtt 1080 tcaccgtgtt ggccaggatg gtctcgattt cctgacttca tgatccgcct gcctcggcct 1140 cccaaagtgc tgggattaca ggctttagct acggcgcccg gccattcccc tcccttttct 1200 gctaggctca ctgaactatt aacgagcaaa aagtaaactt cccttttctt tgagttatta 1260 tacatttggg gtctatttgt tagagcaatg cgcttgccct actatactct ccctgggcct 1320 tgtatgatga aattggtaac agccacaaaa actgcatctg ggacacagaa ggtggtagag 1380 gggaaaataa tctgactgac aaagattctg tttataggtg actttttagg attgtggagt 1440 taggcaaagc tgggatcact cacacagcct gataggggat tttcctacgt gggtgggctg 1500 acctggtggt cctggttaca ctgcccacca gccttctggt gtctctacta ggagtaaggt 1560 gccttctctt tctcctccag gaccccacac ctccagaccc tgctgaggga gggccaccca 1620 tttctagtcc cagctcctac tctaactatc tgtgtgacct taaacaaggc ctttcccctc 1680 tctggcctca gtatccgc ct ctgaataatg gggctgggcc tgccgacctt ctggcccttt 1740 tctgctctgt gagtttgtga acttgtgata gggagacagg agtcctagga aggaaatgga 1800 actggtgata gggagacaag agtcctagga aggaaatgga acttgtgata gggagacaag 1860 agtcctagga aatggaagga gagcacgttt cactctgtcc agcagagggc agcagctacc 1920 cacaaatcaa cagctgagca aggccagggc tgtgtgggag ctatgcacag gttctgcctc 1980 cagaagcctt cagtgcctgc ctctgagcca gagggttcca agcagaagag gtcccgcccc 2040 cggagaggga cctcagagag gtcctccaag cccctctcag ctcttactta cggcatccca 2100 gatgccctat tcctcttctg cagagagaag gtggttcagc cactaaatgg tgctgggacc 2160 tcgcagtttg gtgggaagga ggaagcttac tcaagcaagg aatatgagac aggcaaaaac 2220 ccacgcataa gccaaaagcc cctccaaagc gaggtgttgt tccaggctga caagtgtcca 2280 gcagggtgga cttcagactc cctgttagga actgaattgt gtcccccaaa aagagaaagt 2340 caccccaggg tatgacctaa ttcaggaaag gtcattgcag atgcatttaa ttaaatgaag 2400 atgagctcat gctggagtag ggtggactct gaacccagtg ggacaagcgt ccttattaag 2460 aagagggaaa tctggacaca cacagagcag agaccgccgt gtgaagatgg aggcagagat 2520 cggagagatg ctgccacacg cca caaatgc ctggggctcc cagaaactac acggagcctc 2580 ccccagcggc ttcagcagga gcatggctcg gccaacactt tgatcttggt cttccagcct 2640 ccagaacggt gagtcggtga gtttctgtgg tttaggcccc ccagttgtgg ttgtttctta 2700 cggcagcccc aagaaaccaa tacactcccc cgtccacttt ccacggcaga gtttgggcgt 2760 cactgaatcc cacctccaca gcaggttttg cttggactgc acagtattta ttgatgctgc 2820 tgttggtttt aatttctaat gtgtgtgcct gtagctgtac cactcctcct gatgactcac 2880 ctggctcctg cgggcatctg agatgtggtt tctgctccac acttcctggg ggagcagagg 2940 aactcctcag cctcctctca aacttctctc aggttgtgct gttcactccc tccccaggct 3000 tccggtccac acggacagct ctgaccccga gaagattctt tgtcttagac aaacatctgc 3060 ctccctgtaa cttcggttca ccgatacttg ctctgcactc cagggccata cagaacccct 3120 ctgctattgg ctcctaggag acactagctt gtccggccgt cgctttaaac tgtctagttc 3180 caactccctc agaacttcct cagtgatgca gtttcctgac ggtcatattg cctggataag 3240 ctccagtatg ttcaactccc tctgtggttc agcaaccagg actaaacagg attcacctga 3300 tgcacattct aaccagagtc aagagggcag aagcatcgcc tcctgcgttc caagctcaat 3360 atctcaattg taatccccac gtgtcaagg g aggggcttgg tgggaggtga ttggatcttg 3420 ggggcagttt gccccatgct gttctcataa tagtgagggg tttctcacga gatctgatgg 3480 ttttataagg ggctctttcc cctttgtgca ccctctctct ttcctgcttc cttgtgaaga 3540 aggtacttgc ttctctttct cctgccaaag catgacctta taattgtaag tttccggagg 3600 cctccccagc catgcggaac tgtgagtcaa tgaaacctct ttcttttata aatgacccag 3660 tcttgggtat ttctttatag cagtgtgaaa atggactaac acagatattt ggcaggcatc 3720 cagtagtctt cgataaacac aaccaccatc tagtggccag aacagcctta tcggacccca 3780 ctgtctgcaa tgaaaagctg ttcctttcct catcctttac agggccaagc acccagcatc 3840 ctgggacagt ggccccgtgt gcccagcttt gaggatgagc tcatgcctgg ttgctctggg 3900 tggagagagg gaagagttga atcaacatcc atatgtataa atctcctttt gtgcatttag 3960 aatcacgtcc ttagaataaa ttgcgatcag tggcattact gaagcaaatt gtatcaaaaa 4020 tgcaaaaaag acccatattt ccaaattgtt ttctaacaag gaagtcatat tgtttgcttt 4080 ttgatactgt tctttagaaa acgatgcatg agagttttac atttcctata gtgtgttcta 4140 tttattttat actttgcaat ttctgtaatt tttaagcact gttcttccca tactagaggc 4200 tctgctctaa ctattcaact cttgtttgtc cta gttttcc taaaattccc ttttccactg 4260 gtgtgtggtg caagatgagg cacattttcc atggatggtg aacagaggga ggagcctttt 4320 gatcacaacc aggtcactcc acttctaagc cactgtgcct ccagccccac aagactaagg 4380 agagagagcg cagcgtggtg gagagtgagc tgtgttggga ccattgtttc cgtaacctcg 4440 ttttctgtgt ccagctgaca caccttcaaa gtggcatcag gtcctaaact gtagcttgca 4500 atgtgcctgt ttccagaaac caaggtgaaa gtgctttaga gtcccttccc agcttttttc 4560 tggaaatgca tgtttctctg aactctgagt cccaagaaaa atcacttgag acaccaagaa 4620 aatgggggaa gtgctaaaat tgtgtgggaa ttcaagctta acaataaaca tcaagacatt 4680 tttgataaaa atgaatccac tga cat cgg gga gga gca aga gaa cag cac gct 4733 His Arg Gly Gly Ala Arg Glu Gln His Ala 1 5 10 gac act ggg tca gag gct aag acc gac att tct ggg aac cac tcc cgg 47 Ser Glu Ala Lys Thr Asp Ile Ser Gly Asn His Ser Arg 15 20 25 aag ggc aca gag gag acg ctt tca gcc tct cat cag cca gcc tgg cct 4829 Lys Gly Thr Glu Glu Thr Leu Ser Ala Ser His Gln Pro Ala Trp Pro 30 35 40 gta gct gct gca cgt tat gag tgt gtt cct ggc atg act gct tct aac 48 77 Val Ala Ala Ala Arg Tyr Glu Cys Val Pro Gly Met Thr Ala Ser Asn 45 50 55 aaa gaa atg ctg agg cag tgt cac gct ggt gtc tgt cct cct tac aga 4925 Lys Glu Met Leu Arg Gln Cys His Ala Gly Val Cys Pro Pro Tyr Arg 60 65 70 atg cct gaa cag ttc cat tgactcaaag tgaagatcaa aagaaccaaa 4973 Met Pro Glu Gln Phe His 75 80 tgacagcaat agccaagtgt aatcatcagt aaccctgtgt tctatccaca gttaaaagaa 5033 tattggcaga gaaacagcct tggtgttcca gcaggagtga agaggaacag gaaaacgagt 5093 ggcagtagcc ctgaaacagc cacttctggt ggttgccact cacctgagga tgtgagtctt 5153 ggcaggccag gcttctgggg acagggggcc caaggcacag tagacggtaa tttttaagat 5213 tatggatgga ctgttgggta ctggttaaga attctgggtt tggccaggca cagtggctca 5273 tgcctgtaat cccagcactt tgggagactg aggccggtgg atcacgagct caggaaattg 5333 agaccatcct ggctaacacg gtgaaaccct gtctctccta aaaatacaaa aaaaattagc 5393 caggcttggt gatgggtgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg 5453 tgtgaacctg ggaggcggag cttgcagtga gttgacattg tgccaccaca ctccagcctg 5513 ggagacaaag cgagactcca tctcag 5539 <210> 29 <211> 5445 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2497) .. (3141) <400> 29 ctttttctct gaactatttt tcagtgttgt tactgatgtt gctcagtgta ctgtgattac 60 atgagagcct tatatttagg aaatatgtcc tgaaacactt ggggtaaaaa gatgtcatgt 120 ttgcaactta ctcttaaata gttcagagaa aaagtgtatg tctatgtgta aagcgaagga 180 aagacagaaa gcagctaaaa aagcaaatgt aggccaggcg cggtggctca cgcctgtaat 240 cccagcactt tgggaggcag aggcaggtgg atcacgaggt caggagatcg agaccatcct 300 ggctaatatg gtgaaaacac tgaaaaatag ttaactaatt aatccacaga ttttattcac 360 atttcaccat ttcttcgagt aatgtgcttc actggaaaag gaaatataga tttatgcgtt 420 tctcatgctg ttgtcctata tctttagcca tttttaatct ggaacagttc ctttgtattg 480 tatgagagtt aaatttctct tcctttgggg atattgggta tttcttcatt gtgagattga 540 ggtctgtgcg ctgttgatag aaatcctgca gacatgatgc tgagctctgt cagtgcatca 600 cctcgggagg cagaggccgt ctgtggctcc catagttgaa attctgcagt taaatactgt 660 gtcccagcag tattaactgc agcaacttgg ttagggtggc atctgcagct tcccctactg 720 gaaagctagc agctgccttt tcctgtatgc caggtggtat caacagtgga tcttgatatg 780 cgttgccaaa ttatttgtaa ttcattttcc ttttttctct gaaaattcat tgctggcctt 840 cttcgacctc c ttgttaact aggctgcttg gtatgttcaa aggcatctct gttcctgtcc 900 ccaggcatgc cagaggaaca gagagaaggg ctccaggaag aactgattga catcatcctc 960 ctcatcttgg agcgcaaccc tcagctgcac tactaccagg gctaccatga cattgtggtc 1020 acatttctgc tggtggtagg cgagaggctg gcaacatccc tggtagaaaa attatctacc 1080 caccacctca ggtaccagta gagaggaaca caagacgacg ggcatcactc ctcagccgtc 1140 ctggggataa ctcactggcc tgttttctgg tcagcttttt taggagtttg agccctcgcc 1200 accctgagcc ctgatctaag tgtttggtaa ccaggcttat tgaattgtct ccctccaggg 1260 attttatgga tccaacaatg gacaacacca agcatatatt aaactatctg atgcccatca 1320 ttgaccaggt gaatccagag ctccatgact tcatgcagag gtacatatgt gtctgcattt 1380 ctgtgtgcat gcatacacac gcccacaccc ccccacacct gaaacactcc tcacaagccg 1440 agcgcagttt cctcattgtc ttgggtggat ttgttaagtt ctccccagtt gttccagtca 1500 ccagcaatct gggtaattca gttcttggag catttttggg gactgtgctc tttgggggac 1560 atagcccatc ccttgagttt acatctagtg gggagaggtg gataaggtat gtatgccaag 1620 gtaagatgtt gaggttattg ccacaagaga aacacaaagt cctgtgggat ccagtggcga 1680 gaaggggaag gccaacaat g ggttgtttta tttcccaagt accaaagaga agaaatattt 1740 ttttgcaaat cccatgtgat gttttgtttc ttctctgttt agttggaaat gtgttcttgg 1800 ccaatgcctc tttttttaaa attttttaaa aggtaatggc tatgccttct ttttttttga 1860 gatggagtat tttctcttgt tgcccaggct ggagtgcaat ggcatgatct tggctcactg 1920 caacctctat cttccgggtt caagcgattc ttctgcctca gcctcaagta gctgggatta 1980 caggcatgcg ccaccacgct cggctaattt tgtattttta gtagagacag ggtttctcca 2040 tgttggtcag gctggtctcg agctcccgat gtcaggtgat ccgcccgctt tggcctccca 2100 aagtgctgag attataggcg tgactcaccg tgtctggcag ctacatctta agatatttca 2160 gttgtctcat gttaacagaa aaattaatgc agtcatgttt tcaggcttgg gaatatgtac 2220 ctgtgccccc cagaagggta agacttagtc agaaggagaa tcatggcgta gttctctgaa 2280 aacaactgct tctcgttcct gtagttgaca tttgttggcc agtaggcgag cacccagtga 2340 gataaagcag ccaggaccct gttgtggtgt tagtgttgtg gtacacctta aagactttgt 2400 attaaatatt ttgtaaggag aagatgctga attcctaggt aactgaattt tccagaaatc 2460 ttattcctaa atgcttcctt ctcaccagcg ctataa ggc cca gag aga ggg aag 2514 Gly Pro Glu Arg Gly Lys 1 5 gga tgg ccc aca gga cct gac acc tgc ctt tcc ttt gtt tct agt gct 2562 Gly Trp Pro Thr Gly Pro Asp Thr Cys Leu Ser Phe Val Ser Ser Ala 10 15 20 gag gta ggg acc atc ttt gcc ctc agc tgg ctc atc acc tgg ttt ggg 2610 Glu Val Gly Thr Ile Phe Ala Leu Ser Trp Leu Ile Thr Trp Phe Gly 25 30 35 cat gtc ctg tct gac ttc agg cac gtc gtg cgg tta tat gac ttc ttc 2658 His Val Leu Ser Asp Phe Arg His Val Val Arg Leu Tyr Asp Phe Phe 40 45 50 ctg gcc tgc cac cca ctg atg ccg att tac ttt gca gcc gtg att gtg 2706 Leu Ala Cys His Pro Leu Met Pro Ile Tyr Phe Ala Ala Val Ile Val 55 60 65 70 ttg tat cgc gag cag gaa gtc ctg gac tgt gac tgt gac atg gcc tcg 2754 Leu Tyr Arg Glu Gln Glu Val Leu Asp Cys Asp Cys Asp Met Ala Ser 75 80 85 gtc cac cac ctg ttg tcc cag atc cct cag gac ttg ccc tat gagca 2 His Leu Leu Ser Gln Ile Pro Gln Asp Leu Pro Tyr Glu Thr 90 95 100 ctg atc agc aga gca gga gac ctt ttt gtt cag ttt ccc cca tcc gaa 2850 Leu Ile Ser Arg Ala Gly Asp Leu Phe Val Gln Phe Pro Pro Ser Glu 105 110 11 5 ctt gct cgg gag gcc gct gcc caa cag caa gct gag agg acg gca gcc 2898 Leu Ala Arg Glu Ala Ala Ala Gln Gln Gln Ala Glu Arg Thr Ala Ala 120 125 130 tct act ttc aaa gac ttt gag ctg gca tca gcc cag cag agg cct gat 2946 Ser Thr Phe Lys Asp Phe Glu Leu Ala Ser Ala Gln Gln Arg Pro Asp 135 140 145 150 atg gtg ctg cgg cag cgg ttt cgg gga ctt ctg cgg cct gaa gat cga 2994 Met Val Leu Arg Gln Arg Phe Arg Gly Leu Leu Arg Pro Glu Asp Arg 155 160 165 aca aaa gat gtc ctg acc aag cca agg acc aac cgc ttt gtg aaa ttg 3042 Thr Lys Asp Val Leu Thr Lys Pro Arg Thr Asn Arg Phe Val Lys Leu 170 175 180 180 gca gtg atg ggg ctg aca gtg gca ctt gga gcg gct gca ctg gct gtg 3090 Ala Val Met Gly Leu Thr Val Ala Leu Gly Ala Ala Ala Leu Ala Val 185 190 195 gtg aaa agt gcc ctg gaa tgg gcc cct aag ttt cag ctg cag ctg 138 Lys Ser Ala Leu Glu Trp Ala Pro Lys Phe Gln Leu Gln Leu Phe 200 205 210 ccc tgaaagccag agaagacctt cctcttacat cacattaagg tctcaccctt 3191 Pro 215 ccatggaagg attgggaggg gtggaatttc ctttattaaa agggtttc tg tccagagttt 3251 tttattcctg ccaccctgcc ctgcccgttt gtgtttgcct ttacttcaga ggccaatagc 3311 agagcctacc tgacacagag gggacctggg ggcctggcac agaatcttat gcctctccca 3371 gtgggctttt ggatgggctc tctgccacct ccctggtgtt ggaggaagtg ggtttctgaa 3431 gcttgcagct gcttttgcaa cctgctgggc ctgggctgcc ctagttaccg ggaacctcct 3491 agtcacccca tagaaggtga actggaacat gggatgccct cttactgctc ctgcttgcct 3551 gcatcagatg gacacagaag gagggggctg ctgctgaagg agtcaggctt gggatggaga 3611 gcaagaggcc aaaggactcg tctgggagca tgatcggccc ctcttactag cagctccatc 3671 agctgatcag aaatcagaga cagaagggaa ctaggttact cgttaaatcc tacctatttt 3731 cagcctagaa atcacatggg cgtttccagt caagtgggaa ggaagctcat ttttagggcc 3791 tagacctaga ctagttttgc ctgccttttt ttcctccctg ctttcttcta caagccacac 3851 aacattgctt ataaaaggta cttttattac tatttttaga atatatacac cccatatgta 3911 aattaccctc acttttaaag taataatagt tccttcacgg aaaaaaaaat agttctcatc 3971 agaaggatga gcttctaaga tcctgaattt tactttctac ttgattaaca ttttcgcttt 4031 agccagagtt gctatttgca aacagctttc cacttccaaa gtgccacttt ct gaccggtt 4091 tttcttcctg ttttcctcaa atcatcctac tcccaaatag gcacccactc actaccttgg 4151 cgtcgttttt tgggtctgac ttgtctcgtc aactgctggt ctctcccacc tggttggaaa 4211 tgtcgttgga aacttgcaaa gactctccag accttaggga acaagaggca tcactcagtc 4271 cttctgggac agcttccctg taagcaaagc caggtttgtt ttagattcac tctggcctga 4331 aaaaaaaagt gccttttgct gctttaaaga attggggtat atggtatgaa gcagccatgt 4391 acttgtattt tcctggtctt tcctgggcac tcttctctct tggcagatgt tttcttaaag 4451 tgaacacacc agaagcactc taccccacca tatccagtcc tctttgcatg cctgttgtgt 4511 gcagggtgga gggtgtccca cgtgccagag cagctgggag ccctgtccgc tgagttacac 4571 taagcacttt atttttattt attttattat tattttcttt tttctgagat ggagtctcac 4631 tctgttgccc aggctggagt gcagtggtgc agtctcagct cactgcaacc tccgcctccc 4691 aagttcaggc aattctcgct gcctcagcct cccgagtagc tgggactaca ggcacctgct 4751 accacgcctg gctaattttt gtatttttag tagagatggg gtttcgccac gttggccagg 4811 ctggtctcga actcctgacc tcaggtgatc tgcccgtctc gtcctcccaa agtgctggga 4871 ttacaggtgt gagccaccac gcccagccac cactacgcac tttaaaacca aaaaaagc tc 4931 aaagggatgg atcattgtcc atggctcagg agccccactg tggggtaagt gtgatgtcga 4991 tggattaatt tagacagtgg tgtattcatc agggcaaagg aaattcttcc agaggtgatg 5051 atgcggcaga tattcccagt gctctcccaa agcaagctgg ccctcttgtc atcctctcag 5111 tgggcggcac cagctgcccc tccttccaca agtactcaag cctgtttgta aatactgaag 5171 gaattgatgg ggttgaggaa aggaggtgca tgtgaccagg gtcccaaggc cacagctttt 5231 cagatcctag gaagcaagtg gcatttgctt gagttgtggc ctcggaagga gaatgtttat 5291 ctgttttcta actttgctga caccaggatt ctccctgtca ttgagaagaa agcattatct 5351 aattaccttc aggtggttta cttattctgt aaagaatatg tgtaaatatt ttgtacagag 5411 ccctgtatca aataaacagc catatgtggt tact 5445 <210> 30 <211> 5511 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (35) .. (2269) <400> 30 ggcgcgtctg cggctggtgt tggcgcatct ctag atc ctt tcc cgg agt tca gtt 55 Ile Leu Ser Arg Ser Ser Val 1 5 atg ggt gtg aga ggt ttg caa gga ttt gtg gga agt acc tgc cca cat 103 Met Gly Val Arg Gly Phe Val Gly Ser Thr Cys Pro His 10 15 20 ata tgt aca gta gta aat ttc aaa gaa ctg gca gag cac cac cga agc 151 Ile Cys Thr Val Val Asn Phe Lys Glu Leu Ala Glu His His Arg Ser 25 30 35 aag tat cct gga tgt acc cct acc att gtg gtt gat gcc atg tgt tgt 199 Lys Tyr Pro Gly Cys Thr Pro Thr Ile Val Val Asp Ala Met Cys Cys 40 45 50 55 ctc aga tat tgg tat act cca gaa tct tgg atc tgc ggt ggc cag tgg 247 Leu Arg Tyr Trp Tyr Thr Pro Glu Ser Trp Ile Cys Gly Gly Gln Trp 60 65 70 cga gaa tac ttt tct gct ttg cga gat ttt gtt aaa act ttt acg gca 295 Arg Glu Tyr Phe Ser Ala Leu Arg Asp Phe Val Lys Thr Phe Thr Ala 75 80 85 gct ggg atc aag ttg ata ttc ttc ttt gat ggc atg gtg gag cag gat 343 Ala Gly Ile Lys Leu Ile Phe Phe Phe Asp Gly Met Val Glu Gln Asp 90 95 100 aag aga gat gaa tgg gtg aaa agg ctc aag aac aac agg gag ata 391 Lys Arg Asp Glu Trp Val Lys Arg Arg Leu Lys Asn Asn Arg Glu Ile 105 110 115 tcc agg att ttt cat tac atc aag tca cac aag gag cag cca ggc aga 439 Ser Arg Ile Phe His Tyr Ile Lys Ser His Lys Glu Gln Pro Gly Arg 120 125 130 135 aat atg ttc ttc atc ccc tca ggg cta gct gtg ttt aca cga ttt gct 487 Asn Met Phe Phe Ile Pro Ser Gly Leu Ala Val Phe Thr Arg Phe Ala 140 145 150 cta aag aca ctg ggc cag gaa act ttg tgt tct ttg cag gaa gca gat 535 Leu Lys Thr Leu Gly Gln Glu Thr Leu Cys Ser Leu Gln Glu Ala Asp 155 160 165 tat gag gta gct tcc tat ggc ctc cag cat agg tgt ctg 583 Tyr Glu Val Ala Ser Tyr Gly Leu Gln His Asn Cys Leu Gly Ile Leu 170 175 180 ggg gaa gac act gat tac cta atc tat gac act tgt ccc tac ttt tca 631 Gly Glu Asp Thr Asp Tyr Leu Ile Tyr Asp Thr Cys Pro Tyr Phe Ser 185 190 195 att agc gag ctc tgc cta gag agc ctg gac acc gtc atg ctc tgc aga 679 Ile Ser Glu Leu Cys Leu Glu Ser Leu Asp Thr Val Met Leu Cys Arg 200 205 210 215 gag aag ctc tgt gagctg ggc ctc tgt gtg gcc gac ctt cct ctt 727 Glu Lys Leu Cys Glu Ser Leu Gly Leu Cys Val Ala Asp Leu Pro Leu 220 225 230 ctg gcc tgc ctc ctt ggc aac gac ata atc cca gag ggc atg ttt gaa Leu Leu Gly Asn Asp Ile Ile Pro Glu Gly Met Phe Glu 235 240 245 agc ttt agg tac aaa tgc tta tcg tcc tac acc tct gta aaa gag aac 823 Ser Phe Arg Tyr Lys Cys Leu Ser Ser Tyr Thr Ser Val Lys Glu Asn 250 255 260 ttt gac aaa aaa ggt aac atc ata tta gct gtg tca gac cat ata tcg 871 Phe Asp Lys Lys Gly Asn Ile Ile Leu Ala Val Ser Asp His Ile Ser 265 270 275 aaa aaa gtt ctt tac ttg tat caa ggt gag aaa aaa tta gaa gag ata tta 919 Lys Val Leu Tyr Leu Tyr Gln Gly Glu Lys Lys Leu Glu Glu Ile Leu 280 285 290 295 295 cct ctg gga cca aac aaa gct ctt ttt tat aaa gga atg gca tca tat 967 Pro Leu Gly Pro Asn Lys Ala Phe Tyr Lys Gly Met Ala Ser Tyr 300 305 310 ctt tta cca gga caa aaa tct cca tgg ttt ttc caa aaa ccc aaa ggt 1015 Leu Leu Pro Gly Gln Lys Ser Pro Trp Phe Phe Gln Lys Pro Lys Gly 315 320 325 gta ata act ttg gac aaa caa gta ata tcc acg agt tca gac gcc gaa 1063 Val Ile Thr Leu Asp Lys Gln Val Ile Ser Thr Ser Ser Asp Ala Glu 330 335 340 tcc agg gaa gaa gtt ccc atg tgt tca gat gct gaa tcc agg caa gaa 11 Ser Arg Glu Glu Val Pro Met Cys Ser Asp Ala Glu Ser Arg Gln Glu 345 350 355 gtt ccc atg tgt aca ggc cct gaa tcc agg cga gaa gtt ccc gtg tat 1159 Val Pro Met Cys Thr Gly Pro Glu Ser Arg Arg Glu Val Pro Val Tyr 360 365 370 375 aca gat tct gaa ccc agg caa gaa gtt ccc atg tgt tca gac cct gaa 1207 Thr Asp Ser Glu Pro Arg Gln Glu Val Pro Met Cys Ser Asp Pro Glu 380 385 385 390 ccc agg caa gaa gtt ccc aca tgt aca ggc cct gaa tcc agg cga gaa 1255 Pro Arg Gln Glu Val Pro Thr Cys Thr Gly Pro Glu Ser Arg Arg Glu 395 400 405 gtt ccc atg tgt tca gac cct gaa ccc agg caa gaa gtt ccc atg tgt 1303 Val Pro Met Cys Ser Asp Pro Glu Pro Arg Gln Glu Val Pro Met Cys 410 415 420 aca ggc cct gaa gcc agg caa gaa gtt ccc atg tat aca gac tct gaa 1351 Thr Gly Pro Glu Ala Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu 425 430 435 ccc agg caa gaa gtt ccc atg tat aca gac tct gaa ccc agg caa gaa 1399 Pro Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu Pro Arg Gln Glu 440 445 450 455 gtt ccc atg tat aca ggc tct gaa ccc agg cagg gaa gtt ccc atg tat 1447 Val Pro Met Tyr Thr Gly Ser Glu Pro Arg Gln Glu Val Pro Met Tyr 460 465 470 aca ggc cct gaa tcc agg caa gaa gtt ccc atg tat aca ggc cct gaa 1495 Thr Gly Pro Glu Ser Arg Gln Glu Val Pro Met Tyr Thr Gly Pro Glu 475 480 485 tcc agg caa gaa gtt tta ata cgg aca gac cct gaa tct agg caa gaa 1543 Ser Arg Gln Glu Val Leu Ile Arg Thr Asp Pro Glu Ser Arg Gln Glu 490 495 500 att atg tgt aca ggc cat gaa tcc aaa cag gaa gtt ccc ata tgt aca 1591 Ile Met Cys Thr Gly His Glu Ser Lys Gln Glu Val Pro Ile Cys Thr 505 510 515 gat cct ata tcc aag caa gaa gac tcc atg tgt aca cac gct gaa atc 1639 Asp Pro Ile Ser Lys Gln Glu Asp Ser Met Cys Thr His Ala Glu Ile 520 525 530 535 aat caa aaa tta cct gta gca aca gat ttt gaa ttt aag cta gaa gct 1687 Asn Gln Lys Leu Pro Val Ala Thr Asp Phe Glu P he Lys Leu Glu Ala 540 545 550 ctc atg tgt aca aac cct gaa att aaa caa gaa gac ccc aca aat gtg 1735 Leu Met Cys Thr Asn Pro Glu Ile Lys Gln Glu Asp Pro Thr Asn Val 555 560 565 gg ggg cct gaa gtaag caa gta acc atg gtt tca gac act gaa atc 1783 Gly Pro Glu Val Lys Gln Gln Val Thr Met Val Ser Asp Thr Glu Ile 570 575 580 tta aag gtt gct aga aca cat cac gtc caa gca gaa agc tac ctg gtg 1831 Leu Lys Val Ala Arg Thr His His Val Gln Ala Glu Ser Tyr Leu Val 585 590 595 tac aac atc atg agc agt gga gag att gaa tgc agc aac acc cta gaa 1879 Tyr Asn Ile Met Ser Ser Gly Glu Ile Glu Cys Ser Asn Thr Leu Glu 600 605 610 615 gat gag ctt gac cag gcc tta ccc agc cag gcc ttc att tac cgt ccc 1927 Asp Glu Leu Asp Gln Ala Leu Pro Ser Gln Ala Phe Ile Tyr Arg Pro 620 625 630 att cga cag cgg gtc tac tca gctctta gac tgt caa gat gtc 1975 Ile Arg Gln Arg Val Tyr Ser Leu Leu Leu Glu Asp Cys Gln Asp Val 635 640 645 acc agc acc tgc cta gct gtc aag gag tgg ttt gtg tat cct ggg aac 2023 Thr Ser Thr Cys Leu Ala V al Lys Glu Trp Phe Val Tyr Pro Gly Asn 650 655 660 cca ctg agg cac ccg gac ctc gtc agg ccg ctg cag atg acc att cca 2071 Pro Leu Arg His Pro Asp Leu Val Arg Pro Leu Gln Met Thr Ile Pro 665 670 675 ggg gga acg cct agt ttg aaa ata tta tgg ctg aac caa gag cca gaa 2119 Gly Gly Thr Pro Ser Leu Lys Ile Leu Trp Leu Asn Gln Glu Pro Glu 680 685 690 695 ata cag gtt cgg cgc ttg gac aca ctc cta gcc tgt ctt tcc 2167 Ile Gln Val Arg Arg Leu Asp Thr Leu Leu Ala Cys Phe Asn Leu Ser 700 705 710 tcc tca aga gaa gag ctg cag gct gtc gaa agc cca ttt caa gct ttg 2215 Ser Ser Arg Glu Glu Leu Gln Ala Val Glu Pro Phe Gln Ala Leu 715 720 725 tgc tgc ctc ttg atc tac ctc ttt gtc cag gtg tct gta gtt aac gtt 2263 Cys Cys Leu Leu Leu Ile Tyr Leu Phe Val Gln Val Ser Val Val Asn Val 730 735 740 gag tca taggggag tcatagtaggg tg ttttcccacc 2319 Glu Ser 745 cataaaaata catgtgtttt gttcttgata ctatgtgtgt gcacaacaat gggaaggcca 2379 ttgtcagccc cccaggaggg acacaccgcc tgctgttcca tatgaacgat gcttgctgat 243 9 cctgtgtgtg gtcacgcagc gcagttctac cttcccatcc ctgtgcaggt gactgtcagt 2499 tctttaaatt cacttcaagc agaaaaagcc caggacccca gaacagtaac atcacatccc 2559 tgtttatata agcctgaagc aagacaagcg tcaggaagaa aatttccact ttaccttttt 2619 tctattaata aagacctttt aagtaaaatc tctgtagtgc aagttggcat gagcagactt 2679 ggtaacttgt ctttaaagga gaggtttaaa ttggaacttt taaaaactag aaaacaacag 2739 attgataaat caattttgta ttcgctagat gaagaaggtg ctgtattatt cccagggata 2799 ataactctca gaattaatca ggctaaaaag atacatttat aaaaatatta cagttttata 2859 tattaagcct aaattcgatg ttttgatgtg taatatggga taaaataaca tactgttcag 2919 tgcatgaaaa tgacagagaa actaaataca gttgtgtctt ggtatatgtg agggattggt 2979 cccaggaccc ccaaggatgc caaaatccat gcatcctcaa gtcctgcggt cagcctgtgg 3039 agcccacaga tttgaaaagc tggcccttta tattcgggtt ttacatccca tgaacattgt 3099 atttttccat ctgcatttgg ttgaaaaaaa atccacatat aagtgaaccc atgcaattca 3159 aacctgtatt gtcaggggtc aactgtactc tcatttggtc tgacctccca gttaacaaca 3219 gccacaaatg attttattag agactcatct gagaatatcc tctggaaagg taagtttaca 3279 tcat agaaat gcatatattt tatattcctt ttattccaaa gtaataccta cttggaataa 3339 aagtggacta ggatagtgac atggtgagta agagcattgg caggtccaag cagcagtcag 3399 cacccccacc ctggtggaag caaatgccgc catcctccag gggagcacag gagtctttct 3459 gatttatggt ggggttgttt ttattgcaaa taggcatgtt agccattttt aatatccaag 3519 aagaatcagt gaagttgtta ttcatgggtc tgctgttggc tttctgtttc tttttccgcg 3579 agcctttact tgccgcagaa ggtgctcttc tgagagaagc agctcttgcg gccttaggat 3639 gctgtggagt cgttcagtca gcgggcacgt cctgccttta tctgggtagc tgaacgcggt 3699 ggctgggaga ggaatgtctc tacctcctca cagtgtgggg caggggaagg ggtggcaccg 3759 tctgctcttg atggggtctg gaccgtccgt gtcttccccg ctcttcacgc cctctcctta 3819 tctccatcat ctactccaca ccaagcagtg ttcagtctgt cctttgctgt ctcttgttcc 3879 tctgtccctc cttccttttc tcacttttgc tgcatcttga ttccacagag gattagtagg 3939 gtctcatatt gtgggttctg atttactctc aactaggatt cgaggacaca ggtttcctct 3999 aggttgccaa aagtggatga tgaccccagc tcagcccagc tgtggatatt cgctctctga 4059 aaacccctga actgtttgct ctgtgcaatt tgtcccaaac gtgatcaact gtctggctct 4119 aagacctgg t cttggttggc acctcatgat tattcccaga tgttctgcgg agttttgcct 4179 tgttagagtc taacctgact agaaattcag gctccccttc cagctgggct gtgagttgtg 4239 tgcacaactg gggacaccat agagagagct tcacagccag gagccaagga tggtgtgaag 4299 aggctgtgct ctttccacct gcatactgtc tgctgcctga ggtctgatgc accatgtgtg 4359 tgcctgtgca tgtgcctgtt tgtgcacctg tgcgtgtgcc tgtgtgtaca cctgtgtgtg 4419 tacatgtgtg cccatgtgtg tgtgcatgcc tgtgcgtgta cccatgtgtg tgcacctctg 4479 tgtgcttgtg tgcacatgtg ggtgcctgtg cgtgtgcctg tacgtgcctg tgtgtgcatg 4539 tttgcgccta tacacacact catagttaat aactgagatc aatttgtaag aaatgtttaa 4599 tttttcctgt agcctaacac tggcctttct ctgtcctttt caggtggaca cgctttgcct 4659 ggaggatttg catgcgttta ttgcgcaggc cttgtgcctc caaggaaaat ccacctcgca 4719 gcttgtaaat ctacagcctg attacatcaa ccccagagcc gtgcagctgg gctcccttct 4779 cgtccgcggc ctcaccactc tggttttagt caacagcgca tgtggcttcc cctggaagac 4839 gagtgatttc atgccctgga atgtatttga cgggaagctt tttcatcaga agtacttgca 4899 atctgaaaag ggttatgctg tggaggttct tttagaacaa aatagatctc ggctcaccaa 4959 attccacaac ctga aggcag tcgtctgcaa ggcctgcatg aaggagaaca gacgcatcac 5019 tggccgagcc cactggggct cacaccacgc agggaggtgg ggaagacagg gctccagcta 5079 ccacaggacg ggctctgggt atagccgttc cagtcaggga cagccgtgga gagaccaggg 5139 accaggaagc agacagtatg agcatgacca gtggagaagg tactagtcaa cctccagaaa 5199 gagtatggag agaaaaagag gcacacctgg acgcagagcc ctgccagcgc cctcctctgc 5259 tgttgcagct gcaaggagac catgcctgtg ggagccaggc ctcgcttgca tgaagaagga 5319 acgatgcctt tttcaatggt gtctccctcc cattgtgcag aagagctttt gttggcttct 5379 ctcccgagct tgtgcctgat tctgtggccc aaaacaatca ttgttaacat cttcatgtgt 5439 ttcattctga tctttcattc atatatatga tgcctagcta atttcatttt aaaataaatg 5499 ggaatctgtt gt 5511 <210> 31 <211> 5223 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2546) .. (4969) <400> 31 ctgtaatctt caattatcat ctaaatatta aagaaaaaca ttattttagt actatttttc 60 tatagttttt ccaattttaa ttaaaatttt ttattttttt aatttatttt ttattttatt 120 ttatttttta gacagtcttg ctgtgttgtt caggctggtc tcaaactcct ggcctcaagc 180 aatccttctg cctcagcttc ccaaagtgtt gggattatag gcgtggccaa gtttttctaa 240 tttttaaaaa gctggctatc tgcatttata gaaatagtgt gtagcagaga tcagcagact 300 ttttatgtaa tagaccaaac actaaatatg ctttgcaggc catacaatct gccacagtta 360 cacagttctg ctcttgtagc aggaaagcag acatagacaa tatataatga atggcctagc 420 tatgttctga aaaaaccttg tttacaaaaa catgtgaaga gctagatttg ggccccagga 480 catagtctgc tcacccttga tctgaaccac agattgaaat ttggtgggca gaatggtcca 540 caggtggtca ggcatggtgg ctgatgcctg taatactagc acttcaggag gccggggtgg 600 gaggatcact tgagcccggg agtttgagac cagccttggc agcattgtga gactccatct 660 ccacacacac acacacacaa acacacacac aaacacacac taactgggtt tggtggtgtg 720 cacctgtggt ttttgctact tcaggaggct gaggctgaag tgggaggatt gcttgaagtg 780 ggaggtcaag gctgcagtta tcatgccact atgctccaac ctgggtgaca gagtgagact 840 gtctcaaaaa agaaaaaaag aatggtccac aagccacagt aaagaaccaa gtgtataaaa 900 atttagtgtg agagaattct gctctgattc acacagaaat tcatacatat gttcctgcca 960 tctagagaag cctgtgtagc tgggctactg gaacagagcc actgacctgc cctgctgttc 1020 tttgatgaac taaatgatga tgtgctatgg gctctggaag aaagtggctg acagcagagt 1080 taggcaggca tttcagaaag tcattctggc acccttggaa cttttatgga gttttctgca 1140 gcaacagccc tgtctggtac atcagttgac aactcaggtc tccttgggtc ttgcttgtca 1200 ggctttggca cttaagtgga aagaaaaaga ataagcatta aggaaagcga gagcacagca 1260 gaatcaattt catagtctct catggtttct gccatgggag aaaaatgggc attatactgc 1320 tcacaggcag aataaagact cactggaaac attgctaagc tgccttctcc agaagatgtc 1380 agcggggcag ttgcgtcaat tggcgttccc tgaaccctga gcccagcttt ggggtactct 1440 ttgcttccca cccgtgaagt gacagtgagc agaccctcaa ccttctgctt tctcccacca 1500 aaatgagtga gttttttagt atactttcta ataacaccat tactctgtga ctactctcta 1560 atagtgactc aaattctgtt ataagcttcc tgaagaggag agtaggcatc ttctaaaaag 1620 taaaagaaca gcattagaat gacagaattt tggaattaac agttttgcgc tataagaaca 1680 gggagggtta tcgtaggt at aactaattaa atcttttttt tttttttttg agatggagtc 1740 tcactttttc gcctaggctg gagtgcagtg gcacggtctt ggctcaccgc aacctctgcc 1800 tcccgggttc aagggattct cctgcctcag cctcctgagt agctgggatt acaggtgtgt 1860 gctgccacac ctgggtaatt ttttgtattt ttaatagaga cgggatttcg ccttgttggc 1920 caggctggtc ttgaactcct gacctcaagt gatctgcctg cctcggcctc ccaaagtgct 1980 ggcattacag gcatgagcca cccacaccca gccaactaat tatcttttat accagatccc 2040 actttttact tagtgctgtt agcatagcag tttttataaa cattcttcag gtaggacctg 2100 tttgccttga tatcaaagag atggaaggag ttgctcactt ttgttcccag ccttctttct 2160 agaaatctgc cttccttctt cctatcaaat gttagcggag caccgtctct tctttagctg 2220 tcactgcttg ccttgtacag tgaaggaagt ctggtgagca gcagtccagg aactgcccac 2280 gggtaccctg ggttgggggt tttcctaggc ctttacacag accgcagaat ttatccttga 2340 tatatgctgt catgtggttt gggcatttac tagcattgaa cttatttgag tagacagcag 2400 tgtagtttca acctgttttt tataatgtgt aaatttggat gcttttatag gtagaagcca 2460 ctcattcttc atctaccctt ttttcagtat ctggcaccaa ttctgaccca gtcatttgtg 2520 atccctggct cttgtgatat gct ga aga ttt cca ggc agt ttt tgt gga aca 2572 Arg Phe Pro Gly Ser Phe Cys Gly Thr 15 cct ccc cgt cca gct cta atc aag cac cat ata aac aag aaa ttg cct 2620 Pro Pro Arg Pro Ala Leu Ile Lys His His Ile Asn Lys Lys Leu Pro 10 15 20 25 ggt caa atc tgt gag gac tgt att ctg act gcc aaa gag atc aat act 2668 Gly Gln Ile Cys Glu Asp Cys Ile Leu Thr Ala Lys Glu Ile Asn Thr 30 35 40 gac acc aga atg gca gct act ctc aag tca tta aaa ctt gta aga tac 2716 Asp Thr Arg Met Ala Ala Thr Leu Lys Ser Leu Lys Leu Val Arg Tyr 45 50 55 cga gca ttt tgc agt cct tct gcc ttt ggt gca gtc cga agt gtg tca 2764 Arg Ala Phe Cys Ser Pro Ser Ala Phe Gly Ala Val Arg Ser Val Ser 60 65 70 tac tgg aat gtg agc agc aca cag cat ggg gga cag gac cct cca gaa 2812 Tyr Trp Asn Val Ser Ser Thr Gln His Gly Gly Gln Asp Pro Pro Glu 75 80 85 cac att agc ctc tgc cat tct gcc aaa aaa gtt aag aac ata tgt agc 2860 His Ile Ser Leu Cys His Ser Ala Lys Lys Val Lys Asn Ile Cys Ser 90 95 100 100 acc ttc tct tct cgg aga atc ctg aca acc agc agt gcc cac cca ggt 2908 Thr Phe Ser Ser Arg Arg Ile Leu Thr Thr Ser Ser Ala His Pro Gly 110 115 120 ttg gaa ttc agc aag act tct tcc tct aag gcc agt aca ttg cag ctg 2956 Leu Glu Phe Ser Lys Thr Ser Ser Ser Lys Ala Ser Thr Leu Gln Leu 125 130 135 ggc tca ccc agg gcc aca gga gtt gat gaa gag gac gta gaa gtg ttt 3004 Gly Ser Pro Arg Ala Thr Gly Val Asp Glu Glu Asp Val Glu Val Phe 140 145 150 gat tcc ttt gaa aac atg cga gtt ttc cta cag cta aga cca gaa tac 3052 Asp Ser Phe Glu Asn Met Arg Val Phe Leu Gln Leu Arg Pro Glu Tyr 155 160 165 cgt gtt cac agc tat aat gca tct gag act tct cag ctc ctg tct gtt 3100 Arg Val Ser Tyr Asn Ala Ser Glu Thr Ser Gln Leu Leu Ser Val 170 175 180 185 tca gaa ggt gaa cta att ttg cac aaa gtc aga gtt aat caa aat aat 3148 Ser Glu Gly Glu Leu Ile Leu His Lys Val Arg Val Asn Gln Asn Asn 190 195 200 ctc cag gct caa gtc att gtt gat tat ttg tgt aag ctg agc tct ttg 3196 Leu Gln Ala Gln Val Ile Val Asp Tyr Leu Cys Lys Leu Ser Ser Leu 205 210 215 cct gca gag cag cat cct gtc ttg ctg gc agt acc agc ttt gct ctg 3244 Pro Ala Glu Gln His Pro Val Leu Leu Gly Ser Thr Ser Phe Ala Leu 220 225 230 ctc tgc cag ctg agt gtg aag aag ata cag ctc ttt gat acc caa gat 3292 Leu Cys Gln Leu Ser Val Lys Lys Ile Gln Leu Phe Asp Thr Gln Asp 235 240 245 ctg atc aat gtt ttg aaa gct ttt gtc att tta gga atc cct cac tcc 3340 Leu Ile Asn Val Leu Lys Ala Phe Val Ile Leu Gly Ile Pro His Ser 250 255 260 265 cat tca atg cta gat gtg tat gag acc aag tgt tgc cat cag gta tgg 3388 His Ser Met Leu Asp Val Tyr Glu Thr Lys Cys Cys His Gln Val Trp 270 275 280 gag atg aat atg gat cag ctc ctt ttg gtg gct gat ctc tgg agg tac 3436 Glu Met Asn Met Asp Gln Leu Leu Leu Val Ala Asp Leu Trp Arg Tyr 285 290 295 tta ggc cgc aaa gta cct agg ttt tta aac att ttt tct agt tat ctt 3484 Leu Gly Arg Lys Val Pro Arg Phe Leu Asn Phe Ser Ser Tyr Leu 300 305 310 aat ttg cac tgg aag gat cta tcc ttg tct cag cta gtt cac tta att 3532 Asn Leu His Trp Lys Asp Leu Ser Leu Ser Gln Leu Val His Leu Ile 315 320 325 tat gtt ata ggt ga a aat cgt cag gta tcc cag gac cta atg caa aaa 3580 Tyr Val Ile Gly Glu Asn Arg Gln Val Ser Gln Asp Leu Met Gln Lys 330 335 340 345 ttg gaa tca ttg atc ctt aaa tat ata gat ttg atc aat 628 ttg gag Leu Glu Ser Leu Ile Leu Lys Tyr Ile Asp Leu Ile Asn Leu Glu Glu 350 355 360 gtt ggt acc atc tgt ttg ggg ttc ttt aaa tca agt act aat ctc tct 3676 Val Gly Thr Ile Cys Leu Gly Phe Phe Lys Ser Ser Thr Asn Leu Ser 365 370 375 gaa ttt gtc atg cgg aaa att gga gac ttg gct tgt gct aac att cag 3724 Glu Phe Val Met Arg Lys Ile Gly Asp Leu Ala Cys Ala Asn Ile Gln 380 385 390 cat ctg agt agt cgc tcctta att gtt aaa atg ttc cgt ttc 3772 His Leu Ser Ser Arg Ser Leu Val Asn Ile Val Lys Met Phe Arg Phe 395 400 405 act cac gtg gat cac atc aat ttc atg aag cag att gga gag ata gct 3820 Thr His Val Asp His Ile Asn Phe Met Lys Gln Ile Gly Glu Ile Ala 410 415 420 425 cct cag cga att cct tcc ctg gga gtt caa ggt gtc atg cac ctg act 3868 Pro Gln Arg Ile Pro Ser Leu Gly Val Gln Gly Val Met His Leu Thr 430 43 5 440 ctt tac tgc tcg gcc tta cgc ttc ctg aat gaa gga gta atg aat gca 3916 Leu Tyr Cys Ser Ala Leu Arg Phe Leu Asn Glu Gly Val Met Asn Ala 445 450 455 gtg gct gcg tct ttg cct cct aga cga agt aaa gat 3964 Val Ala Ala Ser Leu Pro Pro Arg Val Ala His Cys Arg Ser Lys Asp 460 465 470 gtt gcc aag att ctg tgg tca ttt ggg act ctg aat tat aag cca ccc 4012 Val Ala Lys Ile Leu Trp Ser Phe Gly Thr Leu Asn Tyr Lys Pro Pro 475 480 485 aat gca gaa gaa ttt tac tcc agc ctg ata agt gag att cac aga aag 4060 Asn Ala Glu Glu Glu Phe Tyr Ser Ser Leu Ile Ser Glu Ile His Arg Lys 490 495 500 500 505 atg cct gaa ttc aac cag tac cca gaa cac ctg ccc acc tgc ctg ctg 4108 Met Pro Glu Phe Asn Gln Tyr Pro Glu His Leu Pro Thr Cys Leu Leu 510 515 520 ggc ctg gca ttt ttg gag tac ttt cca gta gag tta atgat 156 att gat Gly Leu Ala Phe Leu Glu Tyr Phe Pro Val Glu Leu Ile Asp Phe Ala 525 530 535 ctc agt cca ggg ttt gtc agg tta gct cag gag aga act aag ttt gac 4204 Leu Ser Pro Gly Phe Val Arg Leu Ala Gln Glu Arg Thr Lys Phe Asp 540 545 550 ctc ctt aag gaa cta tat acc ctc gat ggt aca gtt ggc att gag tgt 4252 Leu Leu Lys Glu Leu Tyr Thr Leu Asp Gly Thr Val Gly Ile Glu Cys 555 560 565 cca gat tac ga cgg cat c agt act cac ctt cag caa gag ggg 4300 Pro Asp Tyr Arg Gly Asn Arg Leu Ser Thr His Leu Gln Gln Glu Gly 570 575 580 585 tct gaa ttg ctg tgg tat tta gca gag aag gat atg aat tca aag cct 4348 Ser Glu Leu Leu Trp Tyr Leu Ala Glu Lys Asp Met Asn Ser Lys Pro 590 595 600 gaa ttc tta gaa act gtc ttt tta ctg gag acc atg ctg ggg ggg ccc 4396 Glu Phe Leu Glu Thr Val Val Phe Leu Leu Glu Thr Met Leu Gly Gly Pro 605 610 615 cag tac gtc aag cac cat atg att ttg cct cat acc cga tct tct gac 4444 Gln Tyr Val Lys His His Met Ile Leu Pro His Thr Arg Ser Ser Asp 620 625 630 tta gag gtc cag ctt gat gtt aac ctg aag cca tta cca ttt aat aga 4492 Leu Glu Val Gln Leu Asp Val Asn Leu Lys Pro Leu Pro Phe Asn Arg 635 640 645 gaa gcc acg ccg gct gaa aat gta gcc aaa tta agg ctt gag cat gtg 4540 Glu Ala Thr Pro Ala Glu Asn Val Ala Lys Leu Arg Leu Glu His Val 650 655 660 665 gga gtc agc ctt aca gat gat ttg atg aat aag tta cta aaa ggg aaa 4588 Gly Val Ser Leu Thr Asp Asp Leu Met Asn Lys Leu Leu Lys Gly Lys 670 675 680 gca gga cat ttc cag ggc aaa act gag tca gag cct ggg cag cag 4636 Ala Arg Gly His Phe Gln Gly Lys Thr Glu Ser Glu Pro Gly Gln Gln 685 690 695 ccc atg gag ttg gag aat aag gca gct gta cct ctg ggg ggc ttc 4684 Pro Met Glu Leu Glu Asn Lys Ala Ala Val Pro Leu Gly Gly Phe Leu 700 705 710 tgc aat gta gca gat aaa tca ggg gcc atg gag atg gct ggc ctg tgc 4732 Cys Asn Val Ala Asp Lys Ser Gly Ala Met Glu Met Ala Gly Leu Cys 715 720 725 ccc gca gcc tgc atg cag acc cca aga atg aag ctg gct gtt cag ttc 4780 Pro Ala Ala Cys Met Gln Thr Pro Arg Met Lys Leu Ala Val Gln Phe 730 735 740 745 aca aac agg aac cag tat tg tat ggc tcc agg gat ctc ctt gga ctg 4828 Thr Asn Arg Asn Gln Tyr Cys Tyr Gly Ser Arg Asp Leu Leu Gly Leu 750 755 760 cac aat atg aag agg cgg cag ctg gct cgg ctt ggc tac cgt gtg gta 4876 His Met Lys Arg Arg Gln Leu Ala Arg Leu Gly Tyr Arg Val Val 765 770 775 gag tta tcc tac tgg gaa tgg ctc cca cta ctg aaa cga act cgc tta 4924 Glu Leu Ser Tyr Trp Glu Trp Leu Pro Leu Leu Lys Arg Thr Arg Le 780 785 790 gaa aag ttg gcg ttt ctt cat gag aaa gta ttc acc tct gct ctc 4969 Glu Lys Leu Ala Phe Leu His Glu Lys Val Phe Thr Ser Ala Leu 795 800 805 tgaagtag gg cat 5089 ttaattgtat ccaaggcagg ttagagctag tgtatgttac tgtgaattgt aatgtagttg 5149 gattgtacaa attactgcaa atgtatacat gttactctta gtaaataata aacatcttaa 5209 tatgtcctac ggtc 5223 <210> 32 <211> 5716 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3408) <400> 32 gac aaa ccc tca gga agc cct ggc caa ccc cct tct cca gcc cca tct 48 Asp Lys Pro Ser Gly Ser Pro Gly Gln Pro Pro Ser Pro Ala Pro Ser 1 5 10 15 cca gtc cct gaa cct gat gcc caa gct gaa gac gta gct cct ccg ccc 96 Pro Val Pro Glu Pro Asp Ala Gln Ala Glu Asp Val Ala Pro Pro Pro 20 25 30 acc atg gct gag gag gaa gag ggg acc act ggg gag ctc cgc tct gca 144 Thr Met Ala Glu Glu Glu Glu Gly Thr Thr Gly Glu Leu Arg Ser Ala 35 40 45 gag cca gct cca gct gac tct cgc cac cct ctg acc tat cgg aaa acc 192 Glu Pro Ala Pro Ala Asp Ser Arg His Pro Leu Thr Tyr Arg Lys Thr 50 55 60 acc aac ttt gcc ctg gac aag ttt ctc gac cct gcc cgg ccc tat aag 240 Thr Asn Phe Ala Leu Asp Lys Phe Leu Asp Pro Ala Arg Pro Tyr Lys 65 70 75 80 tgc act gtg tgt aag gag tcc ttc acc cag aag aat att ctg ttg gtt 288 Cys Thr Val Cys Lys Glu Ser Phe Thr Gln Lys Asn Ile Leu Leu Val 85 90 95 cat tat aat tct gtc tcc cac ctt cac aag atg aag aag act gct gcc att 336 His Tyr Asn Ser Val Ser His Leu His Lys Met Lys Lys Ala Ala Ile 100 105 110 gac ccc tct gcc cct gca cgg gga gag gcc ggt gcc cca ccc acc acc 384 Asp Pro Ser Ala Pro Ala Arg Gly Glu Ala Gly Ala Pro Pro Thr Thr 115 120 125 act gct gcc aca gac aag ccc ttt aag tgc aca gtc tgc aga gtc tcc 432 Thr Ala Ala Thr Asp Lys Pro Phe Lys Cys Thr Val Cys Arg Val Ser 130 135 140 tac aac cag agc tcc acc ctg gag atc cac atg cgg tca gtt ctg cat 480 Tyr Asn Gln Ser Ser Thr Leu Glu Ile His Met Arg Ser Val Leu His 145 150 155 160 cag act cgc tct cgg gga acc aag act gat tcc aag att gaa ggg cca 528 Gln Thr Arg Ser Arg Gly Thr Lys Thr Asp Ser Lys Ile Glu Gly Pro 165 170 175 gaa cgc agc caa gaa gag ccc aag gaa ggc gag aca gag ggg gag gtg 576 Glu Arg Ser Gln Glu Glu Pro Lys Glu Gly Glu Thr Glu Gly Glu Val 180 185 190 ggc act gag aag aag ggc cct gac acc agt ggc ttc ata tct gga ttg 624 G Glu Lys Lys Gly Pro Asp Thr Ser Gly Phe Ile Ser Gly Leu 195 200 205 cct ttc ctg tcc cct ccc cca cct ccc ttg gac ctg cac cga ttc cca 672 Pro Phe Leu Ser Pro Pro Pro Pro Pro Leu Asp Leu His Arg Phe Pro 210 215 220 gcc cct ctc ttc acc cca cca gtc ctg ccc ccc ttc cct ctg gtg ccc 720 Ala Pro Leu Phe Thr Pro Pro Val Leu Pro Pro Phe Pro Leu Val Pro 225 230 235 240 gaa tca ctg ctt aag ctc cag cag cag cag ctg ctc ctg ccc ttc tac 768 Glu Ser Leu Leu Lys Leu Gln Gln Gln Gln Leu Leu Leu Pro Phe Tyr 245 250 255 ctc cac gat ctc aag gtg ggg ccc aag ctg aca cta gct ggg cct gca 816 Leu His Asp Leu Pro Lys Leu Thr Leu Ala Gly Pro Ala 260 265 270 cct gtg ctg tcc ctg cca gct gcc acc cct cct cct cca ccc caa cct 864 Pro Val Leu Ser Leu Pro Ala Ala Thr Pro Pro Pro Pro Pro Gln Pro 275 280 285 ccc aag gct gag ctg gct gag cgg gag tgg gag cgg ccc ccc atg gcc 912 Pro Lys Ala Glu Leu Ala Glu Arg Glu Trp Glu Arg Pro Pro Met Ala 290 295 300 aaa gag ggt aat gag gca ggg cct tcc tca ccc ccc gac cca ttgcc 960 Lys Glu Gly Asn Glu Ala Gly Pro Ser Ser Pro Pro Asp Pro Leu Pro 305 310 315 320 aac gag gct gcc cgc act gca gcc aaa gcc ctt cta gaa aac ttt ggc 1008 Asn Glu Ala Ala Arg Thr Ala Ala Lys Ala Leu L eu Glu Asn Phe Gly 325 330 335 ttt gag ctg gtg atc cag tac aat gaa ggg aag caa gct gtg ccc cct 1056 Phe Glu Leu Val Ile Gln Tyr Asn Glu Gly Lys Gln Ala Val Pro Pro 340 345 350 350 ccc cct acc cca cccca cct gag gcc ctc ggg ggt ggg gac aag ctg 1104 Pro Pro Thr Pro Pro Pro Pro Glu Ala Leu Gly Gly Gly Gly Asp Lys Leu 355 360 365 gcc tgt ggg gcc tgt ggg aaa ctc ttc tcc aat atg ctt atc ctc aag 1152 Ala Cys Gly Ala Cys Gly Lys Leu Phe Ser Asn Met Leu Ile Leu Lys 370 375 380 aca cac gag gaa cat gtc cac cgc cgc ttt ctg ccc ttt gaa gcc ctg 1200 Thr His Glu Glu His Val His Arg Arg Phe Leu Pro Phe Glu Ala Leu 385 390 395 400 agc cgt tat gct gct cag ttt cga aag agc tat gac agc cta tac ccg 1248 Ser Arg Tyr Ala Ala Gln Phe Arg Lys Ser Tyr Asp Ser Leu Tyr Pro 405 410 415 ccc ctt gca gag cct ccc aaa cct cct gat tct ctg gat tca cct 1296 Pro Leu Ala Glu Pro Pro Lys Pro Pro Asp Gly Ser Leu Asp Ser Pro 420 425 430 gtt ccc cat ctg ggc cca ccc ttc ctg gtc cca gag cct gag gca ggg 1344 Val Pro His Leu Gly Pro Pr o Phe Leu Val Pro Glu Pro Glu Ala Gly 435 440 445 ggg acc cgt gcc cct gaa gag cga agt cga gca ggg gga cac tgg ccc 1392 Gly Thr Arg Ala Pro Glu Glu Arg Ser Arg Ala Gly Gly His Trp Pro 450 455 460 ata gaa gag gaa gaa agc tcc aga ggg aat ctt cct ccc ctg gtg cct 1440 Ile Glu Glu Glu Glu Ser Ser Arg Gly Asn Leu Pro Pro Leu Val Pro 465 470 475 475 480 gcc ggc cgc cgg ttc tcc aga acc aag ttc cag acc caa 1488 Ala Gly Arg Arg Phe Ser Arg Thr Lys Phe Thr Glu Phe Gln Thr Gln 485 490 495 gcc ctg cag tct ttc ttt gag act agc gcc tac ccc aaa gac gga gag 1536 Ala Leu Gln Ser Phe Phe Glu Thr Ser Ala Tyr Pro Lys Asp Gly Glu 500 505 510 gtg gag cga ctc gca agt ctg ttg ggt ctg gct agc cgt gtg gtg gtg 1584 Val Glu Arg Leu Ala Ser Leu Leu Gly Leu Ala Ser Arg Val Val Val 515 520 525 gtg agg gttc cgc cag aaa gca cgc aaa aat gcc tgt gag 1632 Val Trp Phe Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Ala Cys Glu 530 535 540 ggt ggg tcc atg cca acc gga gga ggc act ggg gga gcc tcc ggc Ggly 1680 Ser Met Pro Thr Gly Gly Gly Thr Gly Gly Ala Ser Gly Cys 545 550 555 560 agg cgt tgc cac gcc act ttc tcc tgt gtt ttt gag ttg gtg cgc cac 1728 Arg Arg Cys His Ala Thr Phe Ser Cys Val Phe Glu Leu Val Arg His 565 570 575 ctc aag aag tgc tat gat gac cag acc ctt gaa gag gag gag gaa gag 1776 Leu Lys Lys Cys Tyr Asp Asp Gln Thr Leu Glu Glu Glu Glu Glu Glu 580 585 590 gca gag aga ggg gaa gag ggt gaa gaa gaa gaa gaa gta gag 1824 Ala Glu Arg Gly Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu 595 600 605 gag gaa cag ggc ctt gaa cct cca gca ggg cct gag ggc cca tta cca 1872 Glu Glu Gln Pro Ala Gly Pro Glu Gly Pro Leu Pro 610 615 620 gag cct cca gat ggg gag gag ctg agc caa gca gag gca aca aag gca 1920 Glu Pro Pro Asp Gly Glu Glu Leu Ser Gln Ala Glu Ala Thr Lys Ala 625 630 630 635 640 gga ggc aaa gag cct gaa gag aag gct act cca tca cct tcc cca gcc 1968 Gly Gly Lys Glu Pro Glu Glu Lys Ala Thr Pro Ser Pro Ser Pro Ala 645 650 655 cat acc tgt gac cag tgt gcc att tct ttc tcc agc cag g ac ctc ctg 2016 His Thr Cys Asp Gln Cys Ala Ile Ser Phe Ser Ser Gln Asp Leu Leu 660 665 670 acc agt cac cgc cga cta cat ttc ctg cca tct ctg cag ccc agt gct 2064 Thr Ser His Arg Arg Leu His Phe Leu Pro Ser Leu Gln Pro Ser Ala 675 680 685 ccc ccc caa ctc cta gat ctg ccc ttg ctg gtg ttt ggg gag aga aac 2112 Pro Pro Gln Leu Leu Asp Leu Pro Leu Leu Val Phe Gly Glu Arg Asn 690 695 700 ccc ctg gtg gca acc tca cca atg cca ggt cca cct ctc aaa cgg 2160 Pro Leu Val Ala Ala Thr Ser Pro Met Pro Gly Pro Pro Leu Lys Arg 705 710 715 720 aag cat gag gac ggc agc ttg tct ccc aca ggc agt gaa gca ggg gga 2208 Lys His Glu Asp Gly Ser Leu Ser Pro Thr Gly Ser Glu Ala Gly Gly 725 730 735 gga ggg gag ggc gag ccc ccc agg gac aag cgc ctg cgc acc acc atc 2256 Gly Gly Glu Gly Glu Pro Pro Arg Asp Lys Arg Leu Arg Thr Thr Ile 740 745 750 ttg cct gag cag cta gag atc ctg tac cgt tgg tac atg cag gat tcc 2304 Leu Pro Glu Gln Leu Glu Ile Leu Tyr Arg Trp Tyr Met Gln Asp Ser 755 760 765 aac cca aca cgc aag atg ctc g c atc tcc gag gag gtg ggg ctc 2352 Asn Pro Thr Arg Lys Met Leu Asp Cys Ile Ser Glu Glu Val Gly Leu 770 775 780 aaa aag cga gtg gta cag gtc tgg ttc cag aat acc agg gcc cgg gag 2400 Lys Lys Arg Val Gln Val Trp Phe Gln Asn Thr Arg Ala Arg Glu 785 790 795 800 agg aaa ggc cag ttt cga agc acc cct ggg ggg gtg cct agt cca gca 2448 Arg Lys Gly Gln Phe Arg Ser Thr Pro Gly Gly Val Pro Ser Pro Ala 805 810 815 gtg aaa ccg cct gcc aca gcc acc cct gca tcc ttg ccc aag ttc aac 2496 Val Lys Pro Pro Ala Thr Ala Thr Pro Ala Ser Leu Pro Lys Phe Asn 820 825 830 ctc tta tta ggc aag gta gat gat ggc act ggg aggga gcc cca aag 2544 Leu Leu Leu Gly Lys Val Asp Asp Gly Thr Gly Arg Glu Ala Pro Lys 835 840 845 agg gaa gca cct gct ttt ccc tac ccc act gcc acg ctt gct tct ggg 2592 Arg Glu Ala Pro Ala Phe Pro Tyr Pro Thr Ala Thr Leu Ala Ser Gly 850 855 860 ccc cag cct ttc cta cca cct ggg aaa gag gcc acc acc cca aca cca 2640 Pro Gln Pro Phe Leu Pro Pro Gly Lys Glu Ala Thr Thr Pro Thr Pro 865 870 875 880 gag cca cc t cta cct ctc cta cct ccc cct cca ccc agt gag gaa gag 2688 Glu Pro Pro Leu Pro Leu Leu Pro Pro Pro Pro Pro Ser Glu Glu Glu 885 890 895 895 ggc cca gag gaa cca cct aaa gct tct cca gag agt gag gct tgc agt 2736 Gly Pro Glu Glu Pro Pro Lys Ala Ser Pro Glu Ser Glu Ala Cys Ser 900 905 910 ctc tct gca gga gat ctg agt gat tca tct gct tcc agc cta gct gaa 2784 Leu Ser Ala Gly Asp Leu Ser Asp Ser Ser Ala Ser Ser Leu Ala Glu 915 920 925 cca gaa tcc cct ggg gct gga ggg acc agt ggg gga cct gga ggt ggg 2832 Pro Glu Ser Pro Gly Ala Gly Gly Thr Ser Gly Gly Pro Gly Gly Gly 930 935 940 940 act ggg gtt cca gat gga atg ggg cag cgg cgc tac agg acc cag atg 2880 Thr Gly Val Pro Asp Gly Met Gly Gln Arg Arg Tyr Arg Thr Gln Met 945 950 955 960 agc agc ctg cag ctg aag atc atg aaa gcc tgc tat gaa gct tac cgc 29ln Ser Leu Lys Ile Met Lys Ala Cys Tyr Glu Ala Tyr Arg 965 970 975 acc ccc acc atg cag gag tgt gag gtg ctg gga gag gag att ggg ctg 2976 Thr Pro Thr Met Gln Glu Cys Glu Val Leu Gly Glu Glu Ile Gly Leu 980 985 990 ccc aag aga gtc atc cag gtc tgg ttc cag aat gct cgt gcc aag gaa 3024 Pro Lys Arg Val Ile Gln Val Trp Phe Gln Asn Ala Arg Ala Lys Glu 995 1000 1005 aag aag gcc aaa cta cag ggg aca gcc gct act ggg ggc agc 3072 Lys Lys Ala Lys Leu Gln Gly Thr Ala Ala Gly Ser Thr Gly Gly Ser 1010 1015 1020 agt gag ggc ctc tta gca gcc cag cgc act gac tgc ccc tat tgt gat 3120 Ser Glu Gly Leu Leu Ala Aln Gln Thr Asp Cys Pro Tyr Cys Asp 1025 1030 1035 1040 gtc aag tat gat ttc tat gtc tcc tgc cga ggc cat ctc ttt tcc cgt 3168 Val Lys Tyr Asp Phe Tyr Val Ser Cys Arg Gly His Leu Phe Ser Arg 1045 1050 1055 cag cac gcc aag ctc aag gag gcg gtt cga gcc cag ctg aag agt 3216 Gln His Leu Ala Lys Leu Lys Glu Ala Val Arg Ala Gln Leu Lys Ser 1060 1065 1070 gaa agc aag tgc tac gac ttg gcc cca gca cct gag gct c264 Glu Ser Lys Cys Tyr Asp Leu Ala Pro Ala Pro Glu Ala Pro Pro Ala 1075 1080 1085 ctc aag gcc cca cct gcc acc aca cct gcc tcc atg ccc ctc ggg gct 3312 Leu Lys Ala Pro Pro Ala Thr T hr Pro Ala Ser Met Pro Leu Gly Ala 1090 1095 1100 gcc cca acc ttg cct cgc ctg gcg ccg gtc ctc tta tct ggc cca gct 3360 Ala Pro Thr Leu Pro Arg Leu Ala Pro Val Leu Leu Ser Gly Pro Ala 1105 1110 1115 1120 ct gct cag ccc ccg ctg ggc aac tta gct cct ttc aat tca ggt gag 3408 Leu Ala Gln Pro Pro Leu Gly Asn Leu Ala Pro Phe Asn Ser Gly Glu 1125 1130 1135 tagggaggct gggaggagct ggacttcaga gaacatcccc ctctaatgac atgcccttcc 3468 ttttccttcc tgattcttcc catgcccaat ctcctgtggc cttcctttgc atcaggctct 3528 tgggggaaag aagggaggga aggggcatgg aaatccggtg ctgggaacgg gtgtgtgtgg 3588 ctggaggtgg cctatggcag gaagaatgat gggacaggag atggctaatc cttcatcctt 3648 cctttcacct ttctaggccc ggcagcctcc tcaggcctcc tcggcctcgc cacttcggtc 3708 ctgcctacca ccacagtggt ccagactgct ggcccaggcc gccccttacc tcagagaccc 3768 atgcccgacc aaaccaacac ctccacagca ggcaccactg accctgtccc aggccctcct 3828 actgagccct tgggggacaa ggtctccagt gagcgaaagc cagttgcagg ccccaccagc 3888 tcctccaatg atgccctcaa gaacctcaaa gcattgaaga ccactgtccc agccctgttg 3948 gggggccagt tcctgccctt tccattgccc cctgctgggg gaacagcacc gccagctgtc 4008 tttggccccc agctacaggg ggcctacttc caacagctct atggcatgaa gaaggggcta 4068 tttcccatga accccatgat acctcagacc ctcattgggc tgctccccaa tgccctcctc 4128 cagccgccac cccagccccc tgagcccaca gccacagcac ctccaaagcc tcctgaactg 4188 cctgctccag gggaggggga agctggtgag gttgatgagc tgctgacagg cagcactggc 4248 atctccaccg tggatgtaac ccatcgctac ctgtgccgcc agtgcaagat ggcatttgac 4308 ggggaggccc cggctactgc ccaccagaga tccttctgct tctttgggcg gggctctggg 4368 ggctccatgc cacccccatt gcgggtgccc atctgcacct accactgcct ggcatgtgag 4428 gtgctgctga gtgggcgtga agccctagcc tcccacctgc gctcctcggc ccacaggcgc 4488 aaggcagccc cacctcaagg gggcccaccc atctccatca ccaacgccgc cactgctgcc 4548 tcggctgctg tggcttttgc caaagaggaa gcaagattac ctcacacgga ctccaaccca 4608 aaaactacga ctacctctac acttctagct ttataaacag attaaccaag atggggagag 4668 gggagggcct cagggctccc tcttttaccc caaggggtgt ttggtgggag ctcaaatccc 4728 tcaccccacc ccctggcccc gcccacctca caggaactgt tcagttccca ccctcagtgg 4788 gcaccacaca cccca cttcc agcagagtcc tgcctcctcc caatccccac agacacacac 4848 attgatcctc ctcctcagct ccttgcagat gtagcccttg cccatcttca cagacacata 4908 cacccatctt ggcaccctga ttattcatac atgtctgcct accacacaca aaatatatcc 4968 ttggttctat cttccttttc ctcactgaat tcccagctcc ccatccccat aaatgcatac 5028 acatacatgc acacacacac gttatcccat gatgttccac tgagaaaaca ccaaaaaatt 5088 ttgaaaaaga agataaaaag aagaaacgaa aaagaaagcc caaggcaaag aagggggaag 5148 gaaaacaaac ttcgccactc tctcttctcc ttcctaaccc tttgtctaga gcaccacacc 5208 gctcacaaac tctttccaaa tgctcagttg gctcccaaag ttggagcctg gcatgggcag 5268 ggagcccaca aaactctaac caaactggag gctggcatgg gagaagtgct tctggttcac 5328 tcttcctacc ctctccctcc taaccctctc cttgcctgac aggggagccc ctgtggcctg 5388 gactctaggg gatgccgcca ccagaaaccc ctctgccaat ccctaccttg caccctggga 5448 actgcagtaa cttattctca aaggctttaa acacagagat cctctcagcg gccgtgggcc 5508 tgccccttgt cctagccctg ccacgtgagg gtccagcctc cagggacagg cactgcccac 5568 caacggcaaa tccaaagttc tttcaaaaaa aaaaactgaa acacaaccaa aaaagcaaga 5628 gcgagagaga gtacgtgcac acgcgcacaa aagagagaaa cggacaccag aggaatgaac 5688 taaagaaaaa cgtaaacttg gaaaatac 5716 <210> 33 <211> 4838 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3851) .. (4402) <400> 33 cgcttgaacc tgggaggcgg aggttgcagt gagccgagat cacgccactg cactccagcc 60 tgggtgacag agcgagaccc catctcaaaa aaattagtta attaattaaa aataaataaa 120 taaataaaag ctagatacca ttacataagg catctcatta atcctcccaa ctctgaggaa 180 tgggcgtaat gactcctggt ttacagatga ggagactgag gcttctacag gttaagcttc 240 ttgccctaga tgacaccatg gcagaggggg gatggtggct caaaccacac ctgtctgatt 300 tcaaaacttg gaatgacctt gtattcccca acccagggct gattagagaa aaatagcaac 360 ttcactaatg ctatcattta tgtttctttg ggggcaacca atggcttttt gtcatactaa 420 catcacccac tcatcatacg aaggctgttg agcagatggg ttttttgcag cctaaattca 480 taggttgatc ccatcactga gtgggaggat taaatcagaa cccaccaaaa tgatttgcat 540 ctctgaaacc ataaatccat gctgcccctc aggttctctc actccaaacc tccaaggcat 600 tcattttcag tcctcatcag aacttccaat ctgttggcca tatcaaccac atccccctca 660 ctgccttccc tctctagctt ggattctact cttttaaaaa ctgagctcaa aaggtcttgt 720 cctcagacct tctgtgctgt tctccatcta gcaacaccat ccccacagtt catccaggtt 780 caaccttgga tgaatctgac tttgcaccct gtcctcctgt gcacacaggc tgctgaacag 840 aactgggaat g ccagctggt gctactaata atacaccgtg gtcgtcagtc tcagcaaggc 900 ctgcagtctg cccactggcc ctgctgcctc tcctagctag cgttctccct cgatcttcat 960 taaacctcca ctcttcccag cccctagtcc acccccctct ttcgctggca gcagatgaca 1020 ccttctgttt tacagatgaa atagatgaca tcaacttccc aaaacaaacc aacccattaa 1080 cttcactgct tctgcagcat ccttctctgt ctcttgtctc aaaggacagg ctgtgcttcc 1140 tgctgtggtc tccatccctc cacctgtact ctggatgaac cattcatcgc tgcattcatt 1200 cataaatcaa catttatcga gttcccactg cctggattca tctcctcttg cctcctggcg 1260 cagggcctct cagacattaa tgtgcacgca gatttcctgg ggatcttgtt aaaatgaaaa 1320 ttctgactct ggaggtctgt atttctaata agctgcaggt gatgcaatgc tgcctgcttg 1380 agtgccacaa tttgaggagc aaggttctac caaggagatt cccaaactag tctgcatatc 1440 agagttccct ggggagtttc aaactgactg cagtctgtgc ccctcctcta gagagttggt 1500 ttacttgctc tggggtgtgg cctgggctgt agaatttttc taaagacccc acaccaggtg 1560 attctaacat ggggacaagt ttgggaacca cactccttag ggggctttgc cctccgggtg 1620 cctccattct ctccctgatc cccggtctct cctctgctgc attattccca tcatcattta 1680 aacttattca gtgtcttac a tcttaagaaa aaaaaatagg aaggggagga aagaaaacaa 1740 actacaaaaa ccctccttca gtccaacatt gctcataatc catgctctgt cttttccatt 1800 cctccagtgc ccagcttcat gaagcagtgg tctgctttcc tctctccact cccctccttt 1860 ctcctggccc ccaagccctg agactgctcc cacctggctc cctcgtgact tccttgcacc 1920 ctggactgtc ctctttcgct gccccatcag catgagtctt ctcccacccc cggcccctct 1980 ggtgtccccc agtccctagg cttccagaac tctgcaggca tggcgtttct tctgctgcta 2040 ggcactgctt gcttggtccc atttgcaggc tgtttcctct tcctactcct tgcatgatgg 2100 tcttgccgga gggtccgtta aaaagcctct tcttactaca tattctctct ggcattaagc 2160 actatatcta tgctgctgat atttgcatct ctatttctaa gctaaaccta tcctttgagt 2220 tccaatccct tctatccaat tatcaactag acacctccac caggatgtct ccctggtacc 2280 tccaactcaa caaatcctaa actgaactca tgacgttcgc tcctaaactt actcctcatc 2340 tgatatttcc catccccgtg aagagttttc gttgcacctg ttgcccaagt cagaaatcta 2400 ggtgtcaacc ttgaatccct ctccttctct ttcccatcct tgaatccctc cccttctctt 2460 tcccatccaa atgatcacca agtcttggta acactgcacc atcatgcact gagcacacag 2520 gcccttgcta aacacccaat att cagcatt ttagaaacct gacatccttc ccatcctgat 2580 ggagcttaga gtctggtgat gagctgtggt tggtgctctg taagaagaag ttatagtgca 2640 atcttgaggt ggggagtgga aggaagtgag ttggacagga agcaaggcca gctctatgtg 2700 tttgcccagg aagaaaaaga catggatgaa cttaggtggg tgccgagagg tgtggaggca 2760 ctcagcctgt tgttcttcat tcccaccccc acttccctgt ttgaaagcat gatcagcacc 2820 tgagtttcca cagctgcctc ctcactaccc tccctggccc cagctttgcc catcagaccc 2880 atttgtggac cagcactgaa atgctctcaa agtacaaacc acctcttgcc ctgcttagaa 2940 cccatcagtt tcatcccagt gccctttaaa caagtccaaa ctccttggca gtgcctcacg 3000 ggacccttta tggtctgtct ttgctttcaa ctcacccatt tctgctcttc caaatcacca 3060 cccatacatt cacatacaca tctattttaa gatcctgcag cactcttcct gcccgcagag 3120 cttctttcat gtcttcacat gtcctcatct tgctctcccc actgcctcta gcaggggccc 3180 ctacctctgg tttgtctaga taatgtcccc ttttccttcc agataccagc atcaccatta 3240 ctaccttgac caccatggac ccgacaagca agggtccccc tctgagttgt tcccataggt 3300 ccctcctgct catcctatgt cacctgggct gtgatggctt atttcattat ctttgcctat 3360 tgttcaaaag ctttccatag tatcccaca t tgggtacaat gcctgacaca tagtaggtgc 3420 tcaatgaata tctaatgaac aaatacatga ccaggcccca gaaacagcca aataaaagga 3480 ttttttgaga ctggggcagc ggggagtggt gtttcggctg cagaatccaa agagaaattg 3540 tgaataagca ggcccagagc cccagcggta aattattaac aacacactga atgttcttgc 3600 agctttgttt tgaatgaaaa gtaaaaacac ccccaaattc catcttcaag taaaagcacc 3660 agtcctcgct gtcattaccg caccattgtg agatattgct aagtgtttcc atagctctgt 3720 ctgcagttat agaaatctgt tcttgcttaa tttccccagc accttccaga gagatgtgag 3780 cacagagcat gggcatgggt cgcgctttgt gttctcagtc tggactggcg ttgctggcgc 3840 ctgcctctga cag ctg tgt ttt gtc ttt gtg tct gtc cac aac ccc gtt 3889 Gln Leu Cys Phe Val Phe Val Ser Val His Asn Pro Val 1 5 10 gcc ccc agt gag ag ag gag gag ag gag ag gag ag gag ag ag gag ag ag tgc 3937 Ala Pro Ser Val Glu Ser Arg Leu Asp Leu Arg Lys Asn Leu Arg Cys 15 20 25 cag agc ttc aag tgg tac ctg gag aat atc tac cct gaa ctc agc atc 3985 Gln Ser Phe Lys Trp Tyr Leu Glu Asn Ile Pro Glu Leu Ser Ile 30 35 40 45 ccc aag gag tcc tcc atc cag aag ggc aat atc cga c ag aga cag aag 4033 Pro Lys Glu Ser Ser Ile Gln Lys Gly Asn Ile Arg Gln Arg Gln Lys 50 55 60 tgc ctg gaa tct caa agg cag aac aac caa gaa acc cca aac cta aag 4081 Cys Leu Glu Ser Gln Arg Gln Asn Asn Gln Glu Thr Pro Asn Leu Lys 65 70 75 ttg agc ccc tgt gcc aag gtc aaa ggc gaa gat gca aag tcc cag gta 4129 Leu Ser Pro Cys Ala Lys Val Lys Gly Glu Asp Ala Lys Ser Gln Val 80 85 90 tgg gcc ttc aca tac acc cag cag atc ctc cag gag gag ctg tgc ctg 4177 Trp Ala Phe Thr Tyr Thr Gln Gln Ile Leu Gln Glu Glu Leu Cys Leu 95 100 105 tca gtc atc acc ttg ttc cct ggc gcc cca gtg gtt cttg ctt Val Ile Thr Leu Phe Pro Gly Ala Pro Val Val Leu Val Leu Cys 110 115 120 125 aag aat gga gat gac cga cag caa tgg acc aaa act ggt tcc cac atc 4273 Lys Asn Gly Asp Asp Arg Gln Gln Trp Thr Lys Thr Gly Ser His Ile 130 135 140 gag cac ata gca tcc cac ctc tgc ctc gat aca gat atg ttc ggt gat 4321 Glu His Ile Ala Ser His Leu Cys Leu Asp Thrh Asp Met Phe Gly Asp 145 150 155 ggc acc gag aac ggc aag gaa atc gt gtc aac cca tgt gag tcc tca 4369 Gly Thr Glu Asn Gly Lys Glu Ile Val Val Asn Pro Cys Glu Ser Ser 160 165 170 ctc atg agc cag cac tgg gac atg gtg agc tct tgaggacccc tgccagaagc 4422 Leu Met Ser Gln His Trp Asp Met Val Ser 175 180 agcaagggcc atggggtggt gcttccctgg accagaacag actggaaact gggcagcaag 4482 cagcctgcaa ccacctcaga catcctggac tgggaggtgg aggcagagcc ccccaggaca 4542 ggagcaactg tctcagggag gacagaggaa aacatcacaa gccaatgggg ctcaaagaca 4602 aatcccacat gttctcaagg ccgttaagtt ccagtcctgg ccagtcattc cctgattggt 4662 atctggagac agaaacctaa tgggaagtgt ttattgttcc ttttcctaca aaggaagcag 4722 tctctggagg ccagaaagaa aagccttctt tttcactagg ccaggactac attgagagat 4782 gaagaatgga ggttgtttcc aaaagaaata aagagaaact tagaagttgt ctctgg 4838 <210> 34 <211> 4811 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2296) <400> 34 t cac tcc aaa gcc ttc att gtc gct atg cca aca acc agt aag gcg gat 49 His Ser Lys Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp 1 5 10 15 gtt cag cag aac acg gag gac aat ggg aaa ccc gaa aaa cct gag cct 97 Val Gln Gln Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro 20 25 30 tcc tca cct tct ccc aga gct cca gct tcc tcc caa cac ccc tct gtg 145 Ser Ser Pro Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val 35 40 45 cct gct tct ccc caa ggg aga aat gcc aag gac ctt ctt ctt gac ttg 193 Pro Ala Ser Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu 50 55 60 aag aac aaa ata ttg gct aat ggt ggg gcg ccc cga aaa ccc cag ctt 241 Lys Asn Lys Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu 65 70 75 80 cgc gcc aag aag gca gag gag ctg gat ctt cag tc gaa atc act 289 Arg Ala Lys Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr 85 90 95 ggg gag gag gag ctg ggt tcc cgg gag gac tcg ccc atg tca ccc tca 337 Gly Glu Glu Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser 100 105 1 10 gac acc caa gac cag aaa cgg acc ctg agg ccg cca agt aga cac ggc 385 Asp Thr Gln Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly 115 120 125 cac tcg gtg gtt gct ccc ggc agg act gca gtg agg gcc cgg atg cca 433 His Ser Val Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro 130 135 140 gcg ctg ccc cga agg gaa ggc gta gat aag cct ggc ttt tcc ctg gcc 481 Ala Leu Pro Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala 145 150 155 160 acg cag ccc cgc cca ggg gcg ccc ccc tcg gct tcg gcc tct cct gcc 529 Thr Gln Pro Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala 165 170 175 cac cac gcg tcc acc cag ggc acc tct cat cgt cct tcc ctg cct gcc 577 His His Ala Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala 180 185 190 agc ttg aat gac aac gac ttg gtg gac tca gac gaa gat gag cgc gct 625 Ser Leu Asn Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala 195 200 205 gtg ggc tcc ctc cac ccc aag ggc gcc ttc gcc cag ccc cgg cca gcc 673 Val Gly Ser Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro A la 210 215 220 ctg tcc ccc agc cgc cag tcc ccg tcc agc gtt ctc cgc gac aga agc 721 Leu Ser Pro Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser 225 230 235 240 tct gtg cac ccc ggc gca aag cca gcc tcg ccg gcg cgg agg acc ccc 769 Ser Val His Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro 245 250 255 cat tca ggg gcc gca gag gaa gat tcc agt gcc tca gcc cca ccc tca 817 His Ser Gly Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser 260 265 270 aga ctt tct cca ccc cat ggg gga tca tct cgg ctg ctg ccc acc cag 865 Arg Leu Ser Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thrrl Gln 275 280 285 cca cac ctg agc tct cca ctt tcc aag ggc ggg aag gat ggt gag gac 913 Pro His Leu Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp 290 295 300 gcc cca gcc acc aac tcc aat gcg cca tca cgg tcc acc atg tcc tcc 961 Ala Pro Ala Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser 305 310 315 320 tcc gtc tct tct cat ctc tcg tcc agg acg cag gtc tct gag gga gcg 1009 Ser Val Ser Ser His Leu Ser Ser Arg Thr GlnVal Ser Glu Gly Ala 325 330 335 gag gct tct gat ggt gaa agc cac ggt gac ggc gat agg gaa gac ggc 1057 Glu Ala Ser Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly 340 345 350 350 gga agg cag gc gg acg gcc cag acg ctg cgg gcc cgg cct gcc 1105 Gly Arg Gln Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala 355 360 365 tct gga cac ttc cat ttg ctc aga cac aaa ccc ttt gct gcc aac ggg 1153 Ser Gly His Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly 370 375 380 agg tct cca agc agg ttc agc att ggg cgg gga cct cgg ctg cag ccc 1201 Arg Ser Pro Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro 385 390 395 400 tcc agc tcc cca cag tcg act gtg ccc tcc cga gcc cac ccc agg gtt 1249 Ser Ser Ser Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val 405 410 415 ccc tct cac tct gat tcc cac cct aag ctt agc tca ggt atc cat gga 1297 Pro Ser His Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly 420 425 430 gac gag gag gat gag aag ccg ctt cct gcc acc gtt gtc aat gac cac 1345 Asp Glu Glu Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His 435 440 445 gtg cct tcc tcc tcc agg cag ccc atc tcc cgg ggc tgg gag gac tta 1393 Val Pro Ser Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu 450 455 460 agg aga agc ccg cag aga ggg gcc agc ctg cat cgg aag gaa ccc atc 1441 Arg Arg Ser Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile 465 470 470 475 480 cca gag aac ccc aaa tcc aca ggg gca gat aca cat cg ca ggc aag 1489 Pro Glu Asn Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys 485 490 tac tcc tcc ctg gcc tcc aag gct cag gat gtt caa cag agc aca gac 1537 Tyr Ser Ser Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp 500 505 510 gcg gac acg gag ggt cat tct ccc aaa gca cag cca ggg tcc aca gac 1585 Ala Asp Thr Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp 515 520 525 cgc cac gcg tcc cct gct cgt cct ccc gca gca cgg tca cag cag cat 1633 Arg His Ala Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His 530 535 540 ccc agt gtt ccc aga agg atg aca ccc ggc cgg gcc cca gaa cag cag 1681 Pro S er Val Pro Arg Arg Met Thr Pro Gly Arg Ala Pro Glu Gln Gln 545 550 555 560 ccc cct cct ccc gtc gcc acg tcc cag cac cac ccg gga ccc cag agc 1729 Pro Pro Pro Pro Val Ala Thr Ser Gln His His Pro Gly Pro Gln Ser 565 570 575 aga gac gcg ggt cgg tca cct tcc cag ccc agg ctc tca ctg acc cag 1777 Arg Asp Ala Gly Arg Ser Pro Ser Gln Pro Arg Leu Ser Leu Thr Gln 580 585 585 590 gcc ggg cgg ccc cgc ccc acg tcg cag ggc cgc tcc cac tcc tcc tcg 1825 Ala Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg Ser His Ser Ser Ser 595 600 605 gac cct tac acg gcg agc tcc aga ggg atg ctc ccc acg gcc ctc cag 1873 Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu Pro Thr Ala Leu Gln 610 615 620 aac cag gac gag gat gcc cag ggc agc tac gac gac gac agc aca gaa 1921 Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp Asp Asp Ser Thr Glu 640 630 635 gtc gag gcc cag gat gtg cgg gcc ccc gcg cac gcc gcg cgc gcc aag 1969 Val Glu Ala Gln Asp Val Arg Ala Pro Ala His Ala Ala Ala Arg Ala Lys 645 650 655 gag gca gct gcg tcc ctt ccc aag cac cag cag gag g caa aga cgc 2017 Glu Ala Ala Ala Ser Leu Pro Lys His Gln Gln Gly Arg Gln Arg Arg 660 665 670 cga tgg gag cct cgc caa gga aga gag gga gcc tgc cat cgc gct tgc 2065 Arg Trp Glu Pro Arg Gln Gly Arglu Gly Ala Cys His Arg Ala Cys 675 680 685 ccc tcg cgg agg gag cct ggc tcc tgt gaa gcg acc tct ccc ccc acc 2113 Pro Ser Arg Arg Glu Pro Gly Ser Cys Glu Ala Thr Ser Pro Pro Thr 690 695 700 tcc agg cag ctc ccc cag ggc ctc cca cgt ccc ttc ccg acc gcc gcc 2161 Ser Arg Gln Leu Pro Gln Gly Leu Pro Arg Pro Phe Pro Thr Ala Ala 705 710 715 720 tcg cag cgc tgc cac cgt gag ccc cgt cgc ggg cac ccc ccc 209 g Ser Gln Arg Cys His Arg Glu Pro Arg Arg Gly His Pro Pro Leu Ala 725 730 735 gcg gta cac cac gcg cgc ccc gcc tgg cca ctt ctc cac cac ccc gat 2257 Ala Val His His Ala Arg Pro Ala Trp Pro Leu Leu His His Pro Asp 740 745 750 gct gtc ctt gcg cca gag gat gat gca tgc cag att ccg taaccctctc 2306 Ala Val Leu Ala Pro Glu Asp Asp Ala Cys Gln Ile Pro 755 760 765 tcccgacagc ctgccagacc ctcttacaga caagg atggcagacc aaatgtagaa 2366 gggaaagtcc ttcctggtag taatggaaaa ccgaatggac agagaattat caatggccct 2426 caaggaacaa agtgggttgt ggaccttgat cgtgggttag tattgaatgc agaaggaagg 2486 tacctccaag attcacatgg aaatcctctt cggattaaac taggaggaga tggtcgaacc 2546 attgtagatc tggaagggac ccccgtggtg agtcctgacg gcctcccact ctttgggcag 2606 gggcgacatg gcacacctct ggccaatgcc caagataagc caattttgag tcttggagga 2666 aagccgctgg tgggcttgga ggtcatcaaa aaaaccaccc atccccctac cactaccatg 2726 cagcccacca ctactacgac gcccctgcct accactacaa ccccgaggcc caccactgcc 2786 accacccgcc gcacgaccac caggcgtcca acaaccacag tccgaaccac tacgcggaca 2846 accaccacca ccacccccaa acccaccact cccatcccca cctgtccccc tgggaccttg 2906 gaacggcacg acgatgatgg caacctgata atgagctcca atgggatccc agagtgctac 2966 gctgaagaag atgagttctc aggcttggag actgacacgg cagtacctac ggaagaggcc 3026 tacgttatat atgatgaaga ttatgaattt gagacgtcaa ggccaccaac caccactgag 3086 ccttcgacca ctgctaccac accgagggtg atcccagagg aaggcgccat cagttccttt 3146 cctgaagaag aatttgatct ggctggaagg aaacgatttg ttgat tgaaa gacacaaaca 3206 catggatcca tcaaggagag ctgggggtgt gtttctgagc ttggcatcaa ggctgatgga 3266 gcctccgtcc agcaggaaga gaccgaatgc tccttacgtg acgtacctaa ataaagaccc 3326 atcagccccg tgctctctga ctgatgcact ggatcacttc caagtggaca gcctagatga 3386 aatcatcccc aatgacctga agaagagtga tctgcctccc cagcatgctc cccgcaacat 3446 caccgtggtg gccgtggaag gttgccactc atttgtcatt gtggactggg acaaagccac 3506 cccaggagat gtggtcacag gttacttggt ttacagtgca tcctatgaag acttcatcag 3566 gaacaagtgg tccactcaag cttcatcagt aactcacttg cccattgaga acctaaagcc 3626 caacacgagg tattatttta aagtgcaagc acaaaatcct catggctacg gacctatcag 3686 cccttcggtc tcatttgtca ccgaatcaga taatcctctg cttgttgtga ggcccccagg 3746 cggtgagcct atctggatcc cattcgcttt caaacatgat cccagctaca cggactgcca 3806 tggacggcaa tatgtgaagc gcacgtggta tcgaaagttc gtgggagttg ttctttgtaa 3866 ttcactgagg tataaaatct acctcagtga caacctgaaa gatacattct acagcattgg 3926 agacagctgg ggaagaggtg aagaccattg ccaatttgtg gattcacacc ttgatggaag 3986 aacagggcct cagtcctatg tagaagccct ccctactatt caaggctact atcgccagta 4046 tcgtcaggag cctgtcaggt ttgggaacat cggcttcgga accccctact actatgtggg 4106 ctggtacgag tgtggggtct ccatccctgg aaagtggtaa tcacaggacc gtcatgctgc 4166 aagcttgccc tgcccagccc caccaactaa gtcgcactag gggctgtgag caaagacagc 4226 cagcatgctc agccccgctg ccctaggtgc caggaaggtc acagatggac actggccatt 4286 ctggtcatct cagtctggaa ctcagtccca cttcttggcc tggacaatga acaggattca 4346 gttttgctgt taactttgct tctctacttt tttttgtttg tttgtaatag cacatcccag 4406 agacatcaga aaccagcaac tgattcagtg tgatttccag actttttagg catgaaattc 4466 ggacacttca gtatttccag gaatagcata tgcacgctgt tcttgcttca tggaatgcta 4526 catgctttct gtttttctca ttttggattt ctccaaaact aactgaattt aagcttcagg 4586 tccctttgta tgcagtagaa aggaattatt aaaaacacca ccaaagaaaa taaatatatc 4646 ctacttgaaa tttactctat ggacttaccc actgctagaa taaatgtatc aaatcttatt 4706 tgtaaattct caattttgat atatatatgt atatatgcat atacatatcc acacttgtct 4766 gcaagaatat tgattaaaat tgctaaattt gtacttgttc accag 4811 <210> 35 <211> 4928 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (59) .. (3049) <400> 35 aagcagcacc agaacaccac ctacttcatg gccgacatca tctctgacat gtctgtga 58 gct ctg aag agt tgg ttt cat gac ctg aag cag cac cag aac acc acc 106 Ala Leu Lys Ser Trp Phe His Asp Leu Lys Gln His Gln Asn Thrc 1 5 ctg gcc cag cac ctc aac aag gac agc ctc ctt gcc cgc aag 154 Tyr Phe Leu Ala Gln His Leu Asn Lys Asp Ser Leu Leu Ala Arg Lys 20 25 30 gac ctg ccc ttc cgg atc cag agc tgt gca gcc cag gcc 202 Asp Leu Pro Phe Arg Ile Gln Ser Cys Ala Ala Gln Ala Val Leu Thr 35 40 45 gcc cct tac tct ctt ggg cgc ccg gat ccc aac cca tct ctc caa ccc 250 Ala Pro Tyr Ser Leu Gly Arg Pro Asp Pro Asn Pro Ser Leu Gln Pro 50 55 60 att gcc aca ggc cag agt cct ggc ccc cct ggc gct cgg agg aag ctg 298 Ile Ala Thr Gly Gln Ser Pro Gly Pro Pro Gly Ala Arg Arg Lys Leu 65 70 75 80 ccc cag tca gag ggc cag gta cag gga gaa cga aca tac tcc ttg gca 346 Pro Gln Ser Glu Gly Gln Val Gln Gly Glu Arg Thr Tyr Ser Leu Ala 85 90 95 gtg cac cca gca ctg tcc cca cag ctt agt gaa cag aag aat ctg agt 394 Val Hi s Pro Ala Leu Ser Pro Gln Leu Ser Glu Gln Lys Asn Leu Ser 100 105 110 ctg ctg tcc cca gtt cct gag gac aaa ggg cct ggc cac act agg gca 442 Leu Leu Ser Pro Val Pro Glu Asp Lys Gly Pro Gly His Thr Arg Ala 115 120 125 ggc cta gaa atg tca ctg agg gca gcc aca tca tcc ctc agt gaa gag 490 Gly Leu Glu Met Ser Leu Arg Ala Ala Thr Ser Ser Leu Ser Glu Glu 130 135 140 cag gtc tct gag ctg agg gac aac ctg ccc aag gag gtc agg ttg agc 538 Gln Val Ser Glu Leu Arg Asp Asn Leu Pro Lys Glu Val Arg Leu Ser 145 150 155 160 ccc aag ctt atc ctc gac cca aag agc agt gtg acc cct gcc atc atc 586 Pro Lys Leu Ile Leu Asp Pro Lys Ser Ser Val Thr Pro Ala Ile Ile 165 170 175 tcg gcc gcc cta cag caa gtg gtt cac aat aag agt cta gtc act gct 634 Ser Ala Ala Leu Gln Gln Val Val His Asn Lys Ser Leu Val Thr Ala 180 185 190 ggt ggg gct ttg ggg aac ccc ccc agc agg ggt gag aga agg ctg gag 682 Gly Gly Ala Leu Gly Asn Pro Pro Ser Arg Gly Glu Arg Arg Leu Glu 195 200 205 gcc agc atg ggg agg cca gag gtt agc atg atg agc ag a gt 730 Ala Ser Met Gly Arg Pro Glu Val Ser Met Met Ser Ser Ser Ala Ser 210 215 220 aag aat ctg aag ttc aaa att agc ccc agt gct cca gag acc tca tgg 778 Lys Asn Leu Lys Phe Lys Ile Ser Pro Ser Ala Pro Glu Thr Ser Trp 225 230 235 240 aat tct caa cat cag ctg ggt gca gag gtc tct tcc agc ccc aga gca 826 Asn Ser Gln His Gln Leu Gly Ala Glu Val Ser Ser Ser Pro Arg Ala 245 250 255 ccc aca ggc agc cgg gct gac agc ctg cac ctc tcc caa caa gag gac 874 Pro Thr Gly Ser Arg Ala Asp Ser Leu His Leu Ser Gln Gln Glu Asp 260 265 270 agt ctg cct gtt caa aat ttc cct ccc aaa agc tat ctt ttg cga aca 922 Ser Leu Val Gln Asn Phe Pro Pro Lys Ser Tyr Leu Leu Arg Thr 275 280 285 agc cga gag tca gtg ggc aag caa gct aca ggg gag gtg gca ggc aaa 970 Ser Arg Glu Ser Val Gly Lys Gln Ala Thr Gly Glu Val Ala Gly Lys 290 295 300 ggc ggg cca gtg ggt ggt aag ccc acc ctg cag aag cag ggc acc atc 1018 Gly Gly Pro Val Gly Gly Lys Pro Thr Leu Gln Lys Gln Gly Thr Ile 305 310 315 320 tcc agc caa ggg gag aag gcg cag ctg gag agaca ccc aaa aga agc 1066 Ser Ser Gln Gly Glu Lys Ala Gln Leu Glu Ser Thr Pro Lys Arg Ser 325 330 335 aag ctc gaa gag acc agc ctg gtt ccc cga gct acc tac ccc atg gct 1114 Lys Leu Glu Glu Thr Ser Leu Val Pro Arg Ala Thr Tyr Pro Met Ala 340 345 350 ctg cag agc ccc agc tgc cag tca aga agc cac agc ccc agc tgc cag 1162 Leu Gln Ser Pro Ser Cys Gln Ser Arg Ser His Ser Pro Ser Cys Gln 355 360 365 cct cat ggc cac agc ccc agc agc cag tct cga ggt cag agc ccc agc 1210 Pro His Gly His Ser Pro Ser Ser Gln Ser Arg Gly Gln Ser Pro Ser 370 375 380 tgc caa cct cga ggc cag agc cca ctg agg tct cag gct gcc agc cgg 1 Cys Gln Pro Arg Gly Gln Ser Pro Leu Arg Ser Gln Ala Ala Ser Arg 385 390 395 400 cag gtg agc acc atg ccc tct agg aag ctt gaa aca act ctc aat gga 1306 Gln Val Ser Thr Met Pro Ser Arg Lys Leu Glu Thr Thr Leu Asn Gly 405 410 415 gcc cac tcg acc tct gaa ggc cct gcc aaa ccc aag tca tcc cga ggt 1354 Ala His Ser Thr Ser Glu Gly Pro Ala Lys Pro Lys Ser Ser Arg Gly 420 425 430 cct ttc cgg cta cgc aat t ta ttc tct gcc acc ttc cca acc cgc cag 1402 Pro Phe Arg Leu Arg Asn Leu Phe Ser Ala Thr Phe Pro Thr Arg Gln 435 440 445 aag aag gag aca gat gag cgg cag gcc caa ctg cag aag gta aag cag 1450 Lys Lys Glu Thr Asp Glu Arg Gln Ala Gln Leu Gln Lys Val Lys Gln 450 455 460 tat gaa ctg gag ttc ctt gag gaa ctt cta aag cca cca agc cag ggg 1498 Tyr Glu Leu Glu Phe Leu Glu Glu Leu Leu Lys Pro Pro Ser Gln Gly 470 475 480 gag ctg cca ggc acc gag tac ctg caa cct cca gca cct ggc cgc tgc 1546 Glu Leu Pro Gly Thr Glu Tyr Leu Gln Pro Pro Ala Pro Gly Arg Cys 485 490 495 agc tgc cag ctc cgcggg agcg agcg agcg agc gg ggg cct ggc atg tcc 1594 Ser Cys Gln Leu Arg Ser Ser Pro Val Gln Gln Gly Pro Gly Met Ser 500 505 510 cgt gag cag agg cgc agc tgt gac tgc aag cgc atc tgc cgg ggg ggc 1642 Arg Glu Gln Arg Arg Ser Cys Asg Cys Lys Arg Ile Cys Arg Gly Gly 515 520 525 cgg cca caa gcc acc cag aca cca gtg ccc agc ctc cgg ggg agg gaa 1690 Arg Pro Gln Ala Thr Gln Thr Pro Val Pro Ser Leu Arg Gly Arg Glu 530 535 540 agg ga c aga gtc ctc cct agc cag agg cag cca gag gct ggc cca ggc 1738 Arg Asp Arg Val Leu Pro Ser Gln Arg Gln Pro Glu Ala Gly Pro Gly 545 550 550 555 560 gtg agc ctc agc agc ccc atc tat cgt cgt acc agc 1786 Val Ser Leu Ser Ser Pro Ile Asn Val Gln Arg Ile Arg Ser Thr Ser 565 570 575 ctg gag tcc cga gag tgc cga tcg gac cct gag agt ggt gtt tcg tgc 1834 Leu Glu Ser Arg Glu Cys Arg Ser Asp Pro Glu Ser Gly Val Ser Cys 580 585 590 ctg acc acg tgt gcc tcg ggg ggc gag tgt ctg gga gct ccc aat tac 1882 Leu Thr Thr Cys Ala Ser Gly Gly Glu Glu Cys Leu Gly Ala Pro Asn Tyr 595 600 600 605 agg aaa ctg atg cgcc tac agt atc agt gag ctg gac cag ggt gac 1930 Arg Lys Leu Met Arg Arg Tyr Ser Ile Ser Glu Leu Asp Gln Gly Asp 610 615 620 agg gcc tcg ctg acc tcg gat gtc tac cca cat cct ccc ctg ggc atg 1978 Leu Thr Ser Asp Val Tyr Pro His Pro Pro Leu Gly Met 625 630 635 640 ctg ccc agg gag gcc aag gag gta gag gca agc ctc ccc ata gcc ttg 2026 Leu Pro Arg Glu Ala Lys Glu Val Glu Ala Ser Leu Pro Ile Ala Leu 645 650 655 ggt ccc aaa agc agg tct ctg gag tca ccg acg ctg gga gac ccc tcc 2074 Gly Pro Lys Ser Arg Ser Leu Glu Ser Pro Thr Leu Gly Asp Pro Ser 660 665 670 tac gtc cag gtt gcc cca gag acc aaaggc ccc aga cag atg gcc gtg 2122 Tyr Val Gln Val Ala Pro Glu Thr Lys Gly Pro Arg Gln Met Ala Val 675 680 685 ttc tca ctg ccc gag gag gtg tac cgg aag cct gcc gag cta gac gag 2170 Phe Ser Leu Pro Glu Glu Val Tyr Arg Lys Pro Ala Glu Leu Asp Glu 690 695 700 gac agt gag agc agc aag tgc tgc tcc atc cgc tac tgc ttc tac tac 2218 Asp Ser Glu Ser Ser Lys Cys Cys Ser Ile Arg Tyr Cys Phe Tyr Tyr 705 710 715 715 aag tgt gac atg gca gat gat gcc agt gat ggc aag gat gag ctc 2266 Arg Lys Cys Asp Met Ala Asp Asp Ala Ser Asp Gly Lys Asp Glu Leu 725 730 735 tcc tac tct atc ccc atg aag atc ctg cct ggc atg gag 2314 Ser Tyr Ser Ile Pro Met Lys Ile Leu Pro Gly Met Lys Leu Asp Glu 740 745 750 cag gtg gtg cct gtg gtg agc agg acc ctg cag gtg ctg gat gct gct 2362 Gln Val Val Pro Val Val Ser Arg Thr Leu Gln Val Leu Asp Ala Ala 755 760 765 acc tgc agc agc agc agc cct gag gcc tcc cgc act cag gag att gac 2410 Thr Cys Ser Ser Ser Ser Ser Glu Ala Ser Arg Thr Gln Glu Ile Asp 770 775 775 780 ctc cgt gtg tcc acc ttc gag ggg agc ctg gcc aag atc aat gcc ctg 2458 Leu Arg Val Ser Thr Phe Glu Gly Ser Leu Ala Lys Ile Asn Ala Leu 785 790 795 800 cgg gcc cat gcc tat ggc ctc cct gat ggc ttc ctg gct gcc cgg Ala His Ala Tyr Gly Leu Pro Asp Gly Phe Leu Ala Ala Arg Leu 805 810 815 gac acc aac gag ctg ctg aca gtc ctg cgg cag tgt gtg gcc agc ccc 2554 Asp Thr Asn Glu Leu Leu Thr Val Leu Arg Gln Cys Val Ala Ser Pro 820 825 830 gag gcc cgt gcc ccc aag ccc tat gtg tct cag atc tcc gag tat aag 2602 Glu Ala Arg Ala Pro Lys Pro Tyr Val Ser Gln Ile Ser Glu Tyr Lys 835 840 845 ctt gag cta gct ctc aag ttc aag gagct cgg gcc tcc tgc cgc cgt 2650 Leu Glu Leu Ala Leu Lys Phe Lys Glu Leu Arg Ala Ser Cys Arg Arg 850 855 860 gtg gcc aat gtg gac aag agc cca act cac atg ctg gca gcc atc acg 2698 Val Ala Asn Val Lys Ser Pro Thr His Met Leu Ala Ala Ile Thr 865 870 875 880 ggc agc ttc cag gtg ctg agc agc ctc att gag acc ttc gtg cgg ctg 2746 Gly Ser Phe Gln Val Leu Ser Ser Leu Ile Glu Thr Phe Val Arg Leu 885 895 gtg ttc att gtg cgc tcc gag gcc cag cgc caa gag ctg ctg gcc aag 2794 Val Phe Ile Val Arg Ser Glu Ala Gln Arg Gln Glu Leu Leu Ala Lys 900 905 910 gta gaa gag gtg gtg agg aac tac acc gca gct gag 2842 Val Glu Glu Val Val Arg Asn Tyr Thr Phe Leu Leu Arg Ala Ala Glu 915 920 925 gag tcc aca gcc cgt aac ctt aac cag cag cag cag caa caa caa cag 2890 Glu Ser Thr Ala Arg Asn Leu Asn Gln Gln Gln Gln Gln Gln Gln Gln 930 935 940 cag cag cag caa caa caa cag cag cag caa caa caa cag cag cag cag 2938 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 945 950 955 960 cag cag cag cag gca gca gct gca ggg gca gcc aca gag cat cca cca 2986 Gln Gln Gln Val Ala Ala Ala Ala Gly Ala Ala Thr Glu His Pro Pro 965 970 975 ggc tcc cca act tcg gcg act gtt atg agc aca ttc acc cac tcc tta 3 034 Gly Ser Pro Thr Ser Ala Thr Val Met Ser Thr Phe Thr His Ser Leu 980 985 990 aaa acc ctt att aag tagggcatct gcccacacct gtcccccttc cccaaccatg 3089 Lys Thr Leu Ile Lys 995 gccccaggtt tgagctttgt ggtccttgca tcttgtggtg agtgtgtgtg tgtctgctgg 3149 gccagtcagg gtccaagagc ccatcagtct ccggggagtg gaaactctct tgattgaggt 3209 tctctcttaa gggctgcagg cttagctgcc gccctgggtg tcctcacccc ttccctggcc 3269 tctgggcctc actgtgaggg caaaggcccc tcttcactct gctcacagca gagctgtatt 3329 ttatctcttc tctggggctg agaggtgaca tcaggctcac ttcctgctca atccgtgttg 3389 ggcgctgggg gagccagggc ctgaagcaag cggaccctca ggctttgagc tcctcgtggc 3449 atcggctccc ctgctgggag cagtggcagt aacagcaggc cacattgccg tgccgagggg 3509 agagggcgct cagtccagat gtccccatcc accttgggct cacactcacc tggtagatgc 3569 caccctgagg gcctgtgcct gggtgagatg tctgcagaaa acagccacac taggctgttt 3629 gcagcggccc aactggccgg cagcctggtg agccctcacc tccaggtcca gtagctccac 3689 accagccatc cccaaagtgc cctgcccctc actgatgggc agggcagctc agtccactag 3749 ggagcaagca tctgggatca ccccactcat tttgggtaag gt acctgatg aaaacgtctg 3809 cctggggaga cccagtgcag gcctaggagc ccgcctagcc cggcccagcc cagctcaggg 3869 gctgttgctg caggcatgag gcttctctct caacatctct ctaccagaca gactgtcctt 3929 gggagtttga cttagctgtg gatcggggag gggggtgggg ggagggggga aaggggtagg 3989 ggtggggggt gttgatgact atatcttaaa cttctggaag ctagcgtgat atgttaatcc 4049 tgagtatatg cttttggctg tgtattgacc ctgtggattt gtctctctaa gaaaagaagc 4109 tgagcgcctt acccggtgca gtcctgcacc tttctccctc tctggagcca tctggaaggg 4169 aattcacact gtttaacatc caccttgaca cacacctcct attgccacca ccgctgccac 4229 caccaccgcc accaccgctg ccaaccctcc ccccacgccc cccacccccg caaccttcct 4289 gggagtgaag acacggagtc cctaccaact gtcccactgt agggaacaaa gaaagccaat 4349 gtttcttctg tatagattgc ttctcgtccg cctctccata tctccccatt tcccacaccc 4409 ttgtgccctg tgtctgcctc tgtttcatca ctgtgtcaga ggcccatgtg aaatctttca 4469 ttctgatgtg agttttataa agatgtacac tgtgcttaat ccctgcccat ccttggtagc 4529 ccctagtgca ataaagtctc cctgagtggt gagttctccc ggcaaggagg aggggagttt 4589 cttctgcaga atccagcccc tcacttcctt gcttctcctc ccccagga cc aagttgttga 4649 atgggccaga gatgcagcca gtggggaatc cttttcccct cagccactgc aagctggagt 4709 gctgatatgg tcttcttttt ctcccaactt cgccactcag cccctgcctg tgtcattcca 4769 ccgccatcct tcacctctcc ctcagcctca tggagaggaa acattttcta atgtctgtat 4829 atagtatata tactacataa aatatataaa ttatatatat actaatttat gtcttgtttt 4889 tcaaacaaga atgattaaat ctattcatct tactatccc 4928 <210> 36 <211> 3966 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1391) .. (3775) <400> 36 cagaaccaca gcgggtcctc tgcccggggg aacctgtctg ggaagccgga tgactggccc 60 caggacatga aagagtatgt ggagcgctgc ttcaccgcct gtgagtcgga ggaggacaag 120 gaccgcacgg aaaagctgct caaggaggtg ctgcaggcgc ggctgcagga cggctcggcc 180 tataccattg actggagccg ggagcccttg ccggggctga cccgggagcc tgtggctgag 240 agccctaaga agaagcggtg ggaggccgct agcagccttc accctcctag aggggcaggc 300 tcggcgacaa ggggcggggg tgccccgtcc cagcgaggga cgcccggggc tgggggtgcc 360 ggtcgagccc ggggcaacag cttcaccaag tttggcaacc gcaacgtctt catgaaggac 420 aacagctctt cttccagcac agactcccgc tcccgctcct cctccaggtc cccgacgcgc 480 cacttccgca gaagtgactc ccactcagac tccgacagct cctactcagg gaatgagtgt 540 caccctgtgg gccgcaggaa cccgccccct aagggccggg gcggtcgagg ggcccatatg 600 gatcggggcc gaggcagggc gcagcgtggg aagaggcacg atctggcgcc caccaagcgc 660 agtcgaaaga agatggcggc gctggagtgt gaggacccgg agcgagagct gaagaagcag 720 aagcgggcag cccgcttcca gcacggacac tcccgccgcc tgcgcctcga gcccctggtg 780 ctgcagatga gcagcctgga gagcagtggg gctgaccctg actggcagga gctgcagatc 840 gtgggcacct g ccctgacat caccaagcac tacctgcgcc tcacctgtgc ccccgacccg 900 tccaccgtgc gccctgtggc agttttgaaa aagtcgctgt gcatggtcaa gtgccactgg 960 aaagagaagc aggactacgc gtttgcctgc gagcagatga agtcgatccg gcaggatctg 1020 acggtgcagg gcatccgcac cgagttcacg gtggaggtgt acgagaccca tgcccggatc 1080 gccttggaga agggtgacca tgaagagttt aaccagtgcc agacgcagct caagtcgctg 1140 tacgccgaga acttgcctgg caatgtgggc gagtttactg cctaccgaat cctctactac 1200 atcttcacca agaactcggg agacatcacc acggagctgg catacctcac acgagaactg 1260 aaggcagatc cttgcgtggc ccacgccttg gcattaagga cagccgggtg gcacagcggt 1320 gtcgtggccg tgttgctgat cgcctgggtg gttgttggcg tgtccctgca gcgaaggatc 1380 ctgacagtga aaa agc ag gtg ac gc cag gc cag gc gc cag gc cg gc gag cc gag gtc gtg ggt gat caa cgt agc aca gat tgg 1477 Lys Val Gln Met Ala Ala Asn Val Gly Asp Gln Arg Ser Thr Asp Trp 15 20 25 tct tct cag tac agc atg gtg gct ggg gca ggc cga gag aat ggc atg 1525 Ser Ser Gln Tyr Ser Met Val Ala Gly A la Gly Arg Glu Asn Gly Met 30 35 40 45 gag acg ccg atg cac gag aac ccg gag tgg gag aag gcc cgt cag gcc 1573 Glu Thr Pro Met His Glu Asn Pro Glu Trp Glu Lys Ala Arg Gln Ala 50 55 60 ctg gcc agc atc agc aag tca gga gct gcc ggc ggc tct gcc aag tcc 1621 Leu Ala Ser Ile Ser Lys Ser Gly Ala Ala Gly Gly Ser Ala Lys Ser 65 70 75 agc agc aat ggg cct gtg gcc agt gca cag tac gtg tcc cag gcaga Ser Ser Asn Gly Pro Val Ala Ser Ala Gln Tyr Val Ser Gln Ala Glu 80 85 90 gcc tca gct ttg cag cag cag cag tac tac cag tgg tac cag cag tac 1717 Ala Ser Ala Leu Gln Gln Gln Gln Tyr Tyr Gln Trp Tyr Gln Gln Tyr 95 100 105 aac tat gcc tac ccc tac agc tac tac tat ccc atg ccc cca gtc ccc 1765 Asn Tyr Ala Tyr Pro Tyr Ser Tyr Tyr Tyr Pro Met Pro Pro Val Pro 110 115 120 125 ggc atg gat gag agc atg tcc tac cag gct ccc cct cag cag ctg ccg 1813 Gly Met Asp Glu Ser Met Ser Tyr Gln Ala Pro Pro Gln Gln Leu Pro 130 135 140 tcg gct cag ccc cct cag ccc tca aat ccc cca cat ggg gct cac acg 1861 Ser Ala Gln Pro Pro Gln Pro Ser Asn Pro Pro His Gly Ala His Thr 145 150 155 ctg aac agt ggc cct cag cct ggg aca gct cca gcc aca cag cac agc 1909 Leu Asn Ser Gly Pro Gln Pro Gly Thr Ala Pro Ala Thr Gln His Ser 160 165 170 cag gcg ggg ccc gcc acg ggc cag gcc tat ggg cca cac acc tac acc 1957 Gln Ala Gly Pro Ala Thr Gly Gln Ala Tyr Gly Pro His Thr Tyr Thr 175 180 185 gaa cct gcc aag ccc aag aag ggc caa cag ctg tgg aac cgc atg aaa 2005 Glu Pro Ala Lys Pro Lys Lys Gly Gln Gln Leu Trp Asn Arg Met Lys 190 195 200 205 ccc gcc cct ggg act gga ggt ctc aag ttc aac atc cag aag cga ccc 2053 Pro Ala Pro Gly Thr Gly Gly Leu Lys Phe Asn Ile Gln Lys Arg Pro 210 215 220 ttt gct gtt acc acc cag agc ttt ggc tcc aac gca gag ggc cag cac 2101 Phe Ala Val Thr Thr Gln Ser Phe Gly Ser Asn Ala Glu Gly Gln His 225 230 235 agt ggt ttt ggc ccc cag ccc aac cct gag aaa gtt cag aac cac agc 2149 Ser Gly Phe Gly Pro Gln Pro Asn Pro Glu Lys Val Gln Asn His Ser 240 245 250 ggg tcc tct gcc cgg ggg aac ctg tct ggg aag ccg gat gac tgg ccc 2197 Gly Ser S er Ala Arg Gly Asn Leu Ser Gly Lys Pro Asp Asp Trp Pro 255 260 265 cag gac atg aaa gag tat gtg gag cgc tgc ttc acc gcc tgt gag tcg 2245 Gln Asp Met Lys Glu Tyr Val Glu Arg Cys Phe Thr Ala Cys Glu Ser 270 275 280 285 gag gag gac aag gac cgc acg gaa aag ctg ctc aag gag gtg ctg cag 2293 Glu Glu Asp Lys Asp Arg Thr Glu Lys Leu Leu Lys Glu Val Leu Gln 290 295 300 gcg cgg ctg tac acc att gac tgg agc cgg gag 2341 Ala Arg Leu Gln Asp Gly Ser Ala Tyr Thr Ile Asp Trp Ser Arg Glu 305 310 315 ccc ttg ccg ggg ctg acc cgg gag cct gtg gct gag agc cct aag aag 2ag Pro Leu Pro Gly Leu Thr Ar Glu Pro Val Ala Glu Ser Pro Lys Lys 320 325 330 aag cgg tgg gag gcc gct agc agc ctt cac cct cct aga ggg gca ggc 2437 Lys Arg Trp Glu Ala Ala Ser Ser Leu His Pro Pro Arg Gly Ala Gly 335 340 345 345 tcg gcg aca agg ggc ggg ggt gcc ccg tcc cag cga ggg acg ccc ggg 2485 Ser Ala Thr Arg Gly Gly Gly Ala Pro Ser Gln Arg Gly Thr Pro Gly 350 355 360 365 gct ggg ggt gcc ggt cga gcc cgg ggc aac agc ttc acc aag ttt ggc 2533 Ala Gly Gly Ala Gly Arg Ala Arg Gly Asn Ser Phe Thr Lys Phe Gly 370 375 380 aac cgc aac gtc ttc atg aag gac aac agc tct tct tcc agc aca gac 2581 Asn Arg Asn Val Phe Met Sers Asp Ser Ser Ser Thr Asp 385 390 395 tcc cgc tcc cgc tcc tcc tcc agg tcc ccg acg cgc cac ttc cgc aga 2629 Ser Arg Ser Arg Ser Ser Ser ArArg Ser Pro Thr Arg His Phe Arg Arg 400 405 410 agt gac tcc cac tca gac tcc gac agc tcc tac tca ggg aat gag tgt 2677 Ser Asp Ser His Ser Asp Ser Asp Ser Ser Tyr Ser Gly Asn Glu Cys 415 420 425 cac cct gtg ggc cgc agg aac ccg ccc cct aag ggc cgg ggc ggt cga 2725 His Pro Val Gly Arg Arg Asn Pro Pro Pro Lys Gly Arg Gly Gly Arg 430 435 440 445 ggg gcc cat atg gat cgg ggc cga ggc agg gcg cag cgt ggg aag agg 2773 Gly Ala His Met Asp Arg Gly Arg Gly Arg Ala Gln Arg Gly Lys Ar 450 455 460 cac gat ctg gcg ccc acc aag cgc agt cga aag aag atg gcg gcg ctg 2821 His Asp Leu Ala Pro Thr Lys Arg Ser Arg Lys Lys Met Ala Ala Leu 465 470 475 gag tgt gag gac ccg gag cga gagct aag aag cag aag cgg gca gcc 2869 Glu Cys Glu Asp Pro Glu Arg Glu Leu Lys Lys Gln Lys Arg Ala Ala 480 485 490 cgc ttc cag cac gga cac tcc cgc cgc ctg cgc ctc gag ccc ctg Ggg Arg Ser Arg Arg Leu Arg Leu Glu Pro Leu Val 495 500 505 ctg cag atg agc agc ctg gag agc agt ggg gct gac cct gac tgg cag 2965 Leu Gln Met Ser Ser Leu Glu Ser Ser Gly Ala Asp Pro Asp Trp Gln 510 515 520 520 525 gag ctg cag atc gtg ggc acc tgc cct gac atc acc aag cac tac ctg 3013 Glu Leu Gln Ile Val Gly Thr Cys Pro Asp Ile Thr Lys His Tyr Leu 530 535 535 540 cgc ctc acc tgt gcc ccc gac ccg tcc acc gtg cgc gca gtt 3061 Arg Leu Thr Cys Ala Pro Asp Pro Ser Thr Val Arg Pro Val Ala Val 545 550 555 ttg aaa aag tcg ctg tgc atg gtc aag tgc cac tgg aaa gag aag cag 3109 Leu Lys Lys Ser Leu Cys Met Val Lys Cys His Trp Lys Glu Lys Gln 560 565 570 gac tac gcg ttt gcc tgc gag cag atg aag tcg atc cgg cag gat ctg 3157 Asp Tyr Ala Phe Ala Cys Glu Gln Met Lys Ser Ile Arg Gln Asp Leu 575 580 580 585 acg gtg cag atc cgc acc gag ttc acg gtg gag gtg tac gag acc 3205 Thr Val Gln Gly Ile Arg Thr Glu Phe Thr Val Glu Val Tyr Glu Thr 590 595 600 600 605 cat gcc cgg atc gcc ttg gag aag ggt gac cat gaa gag ttt aac cag 3253 His Ala Arg Ile Ala Leu Glu Lys Gly Asp His Glu Glu Phe Asn Gln 610 615 620 tgc cag acg cag ctc aag tcg ctg tac gcc gag aac ttg cct ggc aat 3301 Cys Gln Thr Gln Leu Lys Ser Leu Tyr Ala Glu Gly Asn 625 630 635 gtg ggc gag ttt act gcc tac cga atc ctc tac tac atc ttc acc aag 3349 Val Gly Glu Phe Thr Ala Tyr Arg Ile Leu Tyr Tyr Ile Phe Thr Lys 640 645 650 aac tcg gga gac atc accg gag gca tac ctc aca cga gaa ctg 3397 Asn Ser Gly Asp Ile Thr Thr Glu Leu Ala Tyr Leu Thr Arg Glu Leu 655 660 665 aag gca gat cct tgc gtg gcc cac gcc ttg gca tta agg aca gcc tgg 3445 Lys Ala Asp Pro Ala His Ala Leu Ala Leu Arg Thr Ala Trp 670 675 680 685 gcc ctg ggc aac tac cac cgc ttt ttc cgg ctc tac tgc cat gca ccc 3493 Ala Leu Gly Asn Tyr His Arg Phe Phe Arg Leu Tyr Cys His Ala Pro 690 695 700 tgc atg tct ggc tac ctc gtg gac aag ttt gca gat cgg gag cgc aag 3541 Cys Met Ser Gly Tyr Leu Val Asp Lys Phe Ala Asp Arg Glu Arg Lys 705 710 715 gtc gcc ctc aag gcc atg gt gt ac g cca agc tcc ctt 3589 Val Ala Leu Lys Ala Met Ile Lys Thr Tyr Val Val Pro Ser Ser Leu 720 725 730 ctg cct ttg ctc ttc cca tcc ttc cgc ctc gtc tca agt tgt ata aag 3637 Leu Pro Leu Leu Phe Pro Ser Phe Ar Leu Val Ser Ser Cys Ile Lys 735 740 745 ttg tct ccg tgt ccc ctc ctc cct ctg ccc cca gtg ttt ctt ctg att 3685 Leu Ser Pro Cys Pro Leu Leu Pro Leu Pro Pro Val Phe Leu Leu Ile 750 755 760 765 ttt ttt tcc cct ttc cct ccc tcc ctc tcc gca ttc ttc cct tgg ttc 3733 Phe Phe Ser Pro Phe Pro Pro Ser Leu Ser Ala Phe Phe Pro Trp Phe 770 775 780 agc aca ggt aaa acg gtt ccc ctc cct ccc tct tct gcc atg 3775 Ser Gly Lys Thr Val Pro Leu Pro Pro Ser Ser Ala Met 785 790 795 taactggagg atgtgctatg agtttgcaaa cagctggact gtcaggctgc tttttttcca 3835 gatgttcctc ctctgcctcc ccttcccctc ctctcccctc cttttccttc cttcc ct 3895 ttccttggag cactgagcac catttggaag cttgagagaa accaaaatta aagagagaaa 3955 gagagagcgt g 3966 <210> 37 <211> 4647 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (945) <400> 37 gcg gcg gag gag gag gcg acc gag aag atg ccc gcc ctg cgc ccc gct 48 Ala Ala Glu Glu Glu Ala Thr Glu Lys Met Pro Ala Leu Arg Pro Ala 1 5 10 15 ctg ctg tgg gcg ctg ctg gcg ctc ctg tgc tgc gcg gcc ccc gcg 96 Leu Leu Trp Ala Leu Leu Ala Leu Trp Leu Cys Cys Ala Ala Pro Ala 20 25 30 cat gca ttg cag tgt cga gat ggc tat gaa ccc tgt gta aat gaa gga 144 His Ala Leu Gln Asp Gly Tyr Glu Pro Cys Val Asn Glu Gly 35 40 45 atg tgt gtt acc tac cac aat ggc aca gga tac tgc aaa tgt cca gaa 192 Met Cys Val Thr Tyr His Asn Gly Thr Gly Tyr Cys Lys Cys Pro Glu 50 55 60 ggc ttc ttg ggg gaa tat tgt caa cat cga gac ccc tgt gag aag aac 240 Gly Phe Leu Gly Glu Tyr Cys Gln His Arg Asp Pro Cys Glu Lys Asn 65 70 75 80 cgc tgc cag aat ggt ggg act tgt gtg gcc cag gcc atgct ggg aaa 288 Arg Cys Gln Asn Gly Gly Thr Cys Val Ala Gln Ala Met Leu Gly Lys 85 90 95 gcc acg tgc cga tgt gcc tca ggg ttt aca gga gag gac tgc cag tac 336 Ala Thr Cys Arg Cys Ala Ser Gly Phe Thr Gly Glu Asp Cys Gln Tyr 100 105 110 tca aca tct cat cca tgc ttt gtg tct cga ccc tgc ctg aat ggc ggc 384 Ser Thr Ser His Pro Cys Phe Val Ser Arg Pro Cys Leu Asn Gly Gly Gly 115 120 125 aca tgc cat atg ctc agc cgg gat acc tat gag tgc acc tgt caa gtc 432 Thr Cys His Met Leu Ser Arg Asp Thr Tyr Glu Cys Thr Cys Gln Val 130 135 140 ggg ttt aca ggt aag gag tgc caa tgg acg gat gcc tgc ctg tct cat 480 Gly Phe Thr Gly Lys Glu Cys Gln Trp Thr Asp Ala Cys Leu Ser His 145 150 155 160 ccc tgt gca aat gga agt acc tgt acc act gtg gcc aac cag ttc tcc 528 Pro Cys Ala Asn Gly Ser Thr Cys Thr Thr Val Ala Asn Gln Phe Ser 165 170 175 tgc aaa tgc ctc aca ggc ttc aca ggg cag aaa tgt gag act gat gtc 576 Cys Lys Cys Leu Thr Gly Phe Thr Gly Gln Lys Cys Glu Thr Asp Val 180 185 190 aat gag tgt gac att cca gga cac tgc cag cat ggt ggc acc tgc ctc 624 Asn Glu Cys Asp Ile Pro Gly His Cys Gln His Gly Gly Thr Cys Leu 195 200 205 aac ctg cct ggt tcc tac cag tgc cag tgc cct cag ggc ttc aca ggc 672 Asn Leu Pro Gly Ser Tyr Gln Cys Gln Cys Pro Gln Gly Phe Thr Gly 210 215 220 cag tac tgt gac agc ctg tat gtg ccc tgt gca ccc tca cct tgt gtc 720 Gln Tyr Cys Asp Ser Leu Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 225 230 235 240 aat gga ggc acc tgt cgg cag act ggt gac ttc act ttt gag tgc aac 768 Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn 245 250 255 tgc ctt cca ggt ttt gaa ggg agc acc tgt gag agg aat att gat gac 816 Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp 260 265 270 tgc cct aac cac agg tgt cag aat gga ggg gtt tgt gtg gat ggg gtc 864 Cys Pro Asn His Arg Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 275 280 285 aac act tac aac tgc cgc tgt ccc cca caa tgg aca ggt atg tac agt 912 Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Met Tyr Ser 290 295 300 gtg gag aat cca cca gaa tgg gat atg gat tgg taaccagagg Gaglugttttt Asn Pro Pro Glu Trp Asp Met Asp Trp 305 310 315 ttttaaaata tcagtaacaa atatcttagg cctgctctgg aaccagtatg tgaactgagc 1025 aggatctcca tgctagatca ttgcttattg tactaacctc atacattttc ctatgttcac 1085 tcaaagacat attttcacag gtattattgg gcagcaactc tgaacccagc accatgctag 1145 atgctgtggc agatatgaga gaagagcact actgtaagct tattatctgg gaaaagcagg 1205 acattacctg gaacatagta gatgcttaat aaatattaaa gaggaaaaat ttcctgaaat 1265 gctaaaataa attgtacagg ctaccagagt tcagagccta tttgttcacg gacagagatc 1325 tgtcccatct taatgtcatg ttctataact aggcaaagtg ttaggcaggt actcttaatg 1385 acattatttt tatgatacgc atcctacatt tgtttttttc ttctatccct ttttgtacac 1445 gaacaaaaat agttttttct gcctctaaca ttagaagggt agtcttgctt aattttacag 1505 cctcttggaa gtttctcatg tagtcttagg caggttgagt gatttatgca gacatttggt 1565 tctaatttct ctttatgtct gtttatctac tgaaagtaga gacaattaag aactgattaa 1625 gggactaaga gctgggcctt tttgagagaa attaatttaa tgtggaaacc caacaggaag 1685 ttagtattat aagaaaaaat tacagtacca gtagtgggct atctcctaca aagaatctta 1745 atgttgaagt gcagccatta ctacctggta ttctttagtg tctctgaatt acttttcctt 1805 atctgtagca tctaattatt tacaatactc tttagagctg tagactatga atagaaaaag 1865 atgaaaagca tttaaaaact caatcacagg acttactggg gaggccaaac atttctgctt 1925 ttaattccca aactgtccct tttaatactt tcccaccagg ttttcctaga attgggactt 1985 ctcctagaat ttcttcatgg tgtcttgatc ctagaacttc acttctaacc ctctgtactt 2045 tttgtgacat tgtctcttct agtttttgcc atttttctat gatagacttt tcagaggcta 2105 ttttttcaac ttaaaaaatt actgtaaagt taattacatg acatatagta actggaaaaa 2165 tttgtgtttt ttttctcttt ttaatgatcc ttacagtatt ggacaggatg agatacttgt 2225 taagaacttg accacattct gatctctccc ttgctctgtg agacagtaac tgtgtagtac 2285 tgaggcttct gatgccagtg aagattaaac aacattgtaa tattgttgct ggtttttgtt 2345 cgatactaca cttggtttct tgctttgata ttaattagga aggcctgctc ttggggaaaa 2405 cttccccagt gaaatgattt ttttattcaa atttcttatc ccaggacatt taataaatgc 2465 ctcttttcgc tagaagtctt tataagatgt ttccgttttt atattttcca aaaagggtgg 2525 tggagatcat ggataagttt aatgtggcag ttttatttct tttgatttgc tgtctgtcat 2585 ttagagtgac cttcagtttt ttttttgtta ttcatcacag gttttcttca ctcatgccaa 2645 ttctttgatt cccagtgaga agccttgttt ttgccctgcc catcatcaac aggagaaagt 2705 ctaagatcct tcttctgtta tatgaagcct ttcatggctt cagctctgtc tgcttcccca 2765 gtctcc ttct catgcatcta gcagcatacc ctagcagttc tctgctcaca gttttcctgt 2825 acatactgca tagtgcttca catcctgtgt cttcattgac accattcctt ttctctaggg 2885 tttccttctc cactcctccc ccatttttct catcattttt ggcatgcctg actcagatca 2945 agtggttacc tgcttcagga aggcttccct gatctcgctc caggctgagc taaatgttct 3005 actctggact cccttagtac cccatgtatt ctcctgtaat aacacttacc acgtttgtat 3065 tgatattatt atatgcttga tgtgagggat gtaccgagtt atgggggcgg ttggactatt 3125 gatgacagca gttactagca ctccttacag acctttgttc tcagtagcat gtagctgagc 3185 tatttaccat cccagcccct atcctattgt aaagagaaaa acagaaggaa aattttgtgt 3245 catagggctt ctgtttctac tgatattaga tgtataaatt cagattagtc ttttctgtgt 3305 tacacaaatt aaagaagtga atggagcagg aatctagtag gagttaacta atgtttatta 3365 gcatccaaat actgtgctaa ttacaatgtt ttatctgtgt aatctttgca ataactgtat 3425 tagagataga gtttaaatat ccttttttca gatgatgatg cgtattcaaa agggttaaat 3485 aatttgccca agacccatag tggttgggtt agggtttgaa tctaggcttg ttgaactcca 3545 aatctttgct caaatctgta gtcttttttc tatataaaat tgattttgta aattatcttg 3605 ttttatttta a gaacttggg gtgtttttta atagactgaa aatttcatta tcctgagatt 3665 tggtgattta ctccatgtgt tttccctttt taagaaccta gctggttatt ttgaggttag 3725 aagttaacat tatgtgtatg ctttagattc agtctgatgc tttttcacta tacctaatag 3785 cctattgcaa ctttgttcag aattcctttt acaatttcca cctgtagact tgaagcatta 3845 actatttggt ctggcttttg acaaaatgaa aaaggagggg ttggagtagt gaggtgagaa 3905 aatgaaggaa atgaagttgc cagctatttg aaaaagaatg gataagacta tatggctgaa 3965 aaaagatagg cattaatttt aaataaatgg agatttggaa atttgccatg cttttaatga 4025 gaagaacctg atagttacgg ctttgttttg taactacata tacataaaag gcttggtgtt 4085 ttgtagcaag ttctacactt caagatgagc ataaattcca gctctattca tggtttgatt 4145 tagggtaaat ttgtcagcct ccttttctca gaagccttca tttgctatta tctctttctt 4205 gggatattga aacaatcaaa aatgcaataa aaagtttatt ttttcatttg ttctgccaac 4265 agctattatg ctaaacattc taaattcatc ctattctata tggtggcccc tggtttcatc 4325 ttgctattga gcatctgaaa tatggctaat gtgaattgag atgtgttgta attgtcaaat 4385 aactgatttt gaagacttag tatggccggg cacagtggct catgcctcta atcccagcac 4445 tttgggaaac tgagat gaat ggatctcttg ggcccaggag tttgagaaca gcctgcgtaa 4505 catggcaaaa ccctgtctct acaaaaaata caaaattagc tgggtgtggt ggcgtgcacc 4565 tgtagtcctg gtcacttggg aggctaatca cgccactgaga catgccacct gag cattccaccc gag cattccaccc gag cattccaccc gag catgccacct gcat <210> 38 <211> 4747 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (60) .. (1775) <400> 38 atggccgcgg ggggcagcgg ctgcacttcc tcagcgggcg gcggtggccg gggagttaa 59 tcc tcg acg cac ggg tcc cgt ttc cct ctg tgc ggc ggc cgg cgg gac 107 Ser Ser Thr His Gly Ser Arg Phe Prog Arg Phe Prog ggc tta act cat ata ttt aac ccc cct cca aaa agg ttt gaa 155 His Lys Gly Leu Thr His Ile Phe Asn Pro Pro Pro Lys Arg Phe Glu 20 25 30 agt att ctt gaa ggg ctg ttt gga cct gca tta tta aaa gat ctc agt 203 Ser Ile Leu Glu Gly Leu Phe Gly Pro Ala Leu Leu Lys Asp Leu Ser 35 40 45 tta ttt aaa gac tgt gaa cct gaa agc att tct gat tgg act ttt gat 251 Leu Phe Lys Asp Cys Glu Pro Glu Ser Ile Ser Asp Trp Thr Phe Asp 50 55 60 gaa aac tgt tta ttc tgt tgc ttg aga aga gat aaa gta aag gga cac 299 Glu Asn Cys Leu Phe Cys Cys Leu Arg Arg Asp Lys Val Lys Gly His 65 70 75 80 tta gtc ggt ctg gat gaaca gct tcg gga gct ggg caa gaa gct ctg 347 Leu Val Gly Leu Asp Glu Pro Ala Ser Gly Ala Gly Gln Glu Ala Leu 85 90 95 ctt aaa caa gag caa gca aaa atc att cga ttc gag aga caa gca gaa 395 Leu L ys Gln Glu Gln Ala Lys Ile Ile Arg Phe Glu Arg Gln Ala Glu 100 105 110 gaa ttc ctc aat gca gtc ttt tat aga aaa aaa gac agt ccc tgg gtc tcc 443 Glu Phe Leu Asn Ala Val Phe Tyr Arg Lys Asp Ser Pro Trp Ser 115 120 125 gac ccc aat att ccc cta gtg gcc cgt gag atc atg cag cga atg atc 491 Asp Pro Asn Ile Pro Leu Val Ala Arg Glu Ile Met Gln Arg Met Ile 130 135 140 caa caa ttt gct gct gaa tat acc tca aaa aat agc tct act cag gac 539 Gln Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn Ser Ser Thr Gln Asp 145 150 155 160 ccc agc cag ccc aat agc aca aag aac caa agc ctg ccg aaa gca tct 587 Pro Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser Leu Pro Lys Ala Ser 165 170 175 cca gtc acc acc tct ccc acg gct gca act act cag aac cct gtg ctc 635 Pro Val Thr Thr Ser Pro Thr Ala Ala Thr Thr Gln Asn Pro Val Leu 180 185 190 agc aaa ctt ctc atg gct gac caa gac tca cct ctg gac ctt act gtc 683 Ser Lys Leu Leu Met Ala Asp Gln Asp Ser Pro Leu Asp Leu Thr Val 195 200 205 aga aag tct cag tca gaa cct agc gaa caa gac ggt gta ctt gatctg 731 Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp Gly Val Leu Asp Leu 210 215 220 tcc act aag aaa agt cca tgt gct ggc agc act tcc ctg agc cac tct 779 Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr Ser Leu Ser His Ser 225 230 235 240 cca ggc tgc tcc agt act caa ggg aac ggg cga cct ggg aga ccc agc 827 Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg Pro Gly Arg Pro Ser 245 250 255 cag tac cgc cca gac gga ctt cgg agt ggt gat ggg gta cct cca aga 875 Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp Gly Val Pro Pro Arg 260 265 270 agc tta cag gat gga acc agg gaa ggt ttt gga cac tcc aca tca ctc 923 Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly His Ser Thr Ser Leu 275 280 285 aaa gtt cca ctg gct cga tcc ctg cag att agt gaa gaa cta ctg agc 971 Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser Glu Glu Leu Leu Ser 290 295 300 aga aac caa ttg tcc aca gct gcc agc ctt ggg cca tct gga tta cag 1019 Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly Pro Ser Gly Leu Gln 305 310 315 320 aat cat gga caa cac tta ata tta tcc agg gaa gcc tct tgg gca aaa 1067 Asn His Gly Gln His Leu Ile Leu Ser Arg Glu Ala Ser Trp Ala Lys 325 330 335 cca cat tac gag ttc aac ctc agc cgt atg aag ttc agg gga aat ggt 1115 Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys Phe Arg Gly Asn Gly 340 345 350 gca ctc agc aac atc agt gac ctt cct ttt ctt gca gaa aac tct gcc 1163 Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu Ala Glu Asn Ser Ala 355 360 365 ttt cca aaa atg gca ctt caa gca aaa caa gat gga aaa aag gat gtg 1211 Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp Gly Lys Lys Asp Val 370 375 380 agc cat tca tct cct gta gat tta aag ata cca caa gtt cga gg atg 1 Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro Gln Val Arg Gly Met 385 390 395 400 gat ctt tct tgg gag tct cgc act ggt gat cag tac agc tat agc tct 1307 Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln Tyr Ser Tyr Ser Ser 405 410 415 ttg gta atg ggt tca caa acg gag agc gcg ctt agt aaa aaa tta agg 1355 Leu Val Met Gly Ser Gln Thr Glu Ser Ala Leu Ser Lys Lys Leu Arg 420 425 430 gct att ctt cca aaa caa agt aga aaa agc atg tta gat gct gga ccc 1403 Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met Leu Asp Ala Gly Pro 435 440 445 gat tct tgg ggc tca gat gct gag cag tct acc tct gga cag cca tat 1451 Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr Ser Gly Gln Pro Tyr 450 455 460 ccc aca tcg gat caa gaa gga gac cct ggc tcc aag cag cct cgg aag 1499 Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser Lys Gln Pro Arg Lys 465 470 475 480 aaa aga ggg cgt tac aga cag tac aac agt gag ata ctg gag gaa gca 1547 Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu Ile Leu Glu Glu Ala 485 490 495 atc tca gtg gtt atg agt gga gat atg tcc aaa gct cag agt 1595 Ile Ser Val Val Met Ser Gly Lys Met Ser Val Ser Lys Ala Gln Ser 500 505 510 att tat ggg att ccc cac agt aca ctg gag tac aaa gta aag gag agg 1643 Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr Lys Val Lys Glu Arg 515 520 525 ctg ggc act ttg aaa aac cct cca aag aaa aag atg aaa tta atg agg 1691 Leu Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys Met Lys Leu Met Arg 530 535 540 tcg ag ggg cca gat gtt tct gta aag att gaa tta gat ccc cag gga 1739 Ser Glu Gly Pro Asp Val Ser Val Lys Ile Glu Leu Asp Pro Gln Gly 545 550 555 555 560 gag gca gca caa agt gca aat gaa tca aaa aac gag taggaatact 1 Glu Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn Glu 565 570 gtagagtgcc aattactgta caaactgggt gagcactact gcatcattgt tcagctatca 1845 ttgcttgcac gtaatttcat ttactgtgac acttgcttct ttgcagattt tgcattgact 1905 tgtgtgtaca gagatgaaat gtgcattctg aatgttgcat attttaaatt tttcatgtgc 1965 agtatggctc ggaatatgtt tggccttttg catgtttctc tacaaaagag aattgagtta 2025 cctcacagag aacagataca tggaagtgga ctccttgcct gtagagcctg catgcttttt 2085 tgtttttttt tgttgttgtt gttttttctt aagttatatt tgtttttact ttttaaaaaa 2145 gaagaggaaa caaagccccc ttttagaaac tacgtctgtc atactgggag ctttatcact 2205 gcaaattgga aagccatctt atacaaaatt attcacattt ttcatctacg attcaactaa 2265 tcgaaggatt aaactaaaga aaaaactaag aagaacaatg aacctttgac tttgagaaat 2325 ttggttattc actgacataa ttattgggtc atttatagtt acattttata attttcttct 2385 cactattaaa tttatttaaa ttag caagct attagtgctc acccagaggg gaaggtggtg 2445 gaaaatgtgc acacactacc ttcagaaatg cttcagttaa ttactttgaa cactaccttt 2505 gctgtaattt catttgagat tttctaaggg tagaatttgg tctcaccaac aagtgaggat 2565 atagccttat ctcatggagg acgagctccg tatttactca ggagcagtca gggtacatta 2625 cataaaacaa tggaggatgc ctcattttag caaactaggt ttctttgtat tcttcagtcc 2685 ttttacagaa ttgatgtgct aactgaatat cattgcagca actagactaa gatattcaag 2745 atctctttat tggggatggg agaaataggg aaagaaatgt gtataagtaa ttatgatatt 2805 gcaaaagtga tacttagatt ttacagcctc agtagtctgc ccagtgtcca cattaatgaa 2865 ggatccatgt ttgtagtgag agaaaaaaac cccaaggtaa cccgatatga tttaggatgc 2925 atatcagttc taacaattca atcagaagtc aagctcattg gaattccttt tttaactgat 2985 ccaaatacta gtagaagggg gagggagagg tgttgggttt tttttttaag tttttattta 3045 attttgttgg ttagaatttt tttctgtttt tggcatccta cataataccc cccttcttga 3105 ctttttctga taattagctg atattcatgg ttgtttagca cacagttcag gacctttgag 3165 atcatgtttg tataagcact ccttgaagaa tatctaagct ttttctgaga tgggctttta 3225 aaattataat aagggaagtt tattttctgc ggtttttgca agaataagca aagcccatgg 3285 aatttaattt ttcattgtga tcagattaaa attactattt gtgcaaaaca aattccacac 3345 cacatgtact gtatattcta atctgctgag aaaggtggtc aggcccttct aaatgcttaa 3405 ccaaaaacaa acattattgg agtttcagtg taaaataaaa ttaaaattgg agggttggtt 3465 agattgattt cagatggata ctaacagttt gaggggaggt ccagatattt ccaaggcata 3525 aattcttgcc tggaaacttt ggagcaatta attaaattag gttaagtttt ccctcagcaa 3585 cctgtgtgtt caaaggttag gcacaccatt gctgttacta aaatacatgc actgctcatt 3645 cttgacatag cttgggtgtg ggttcctctt gttttggtta ttttgtgtag cagtttaatc 3705 agtggataac tgagcctgtt tcctcttagc tttctagact tcttaacaga aaaaacagtt 3765 tgggttcaat agcattttat gattctacaa tattttgtca cctagctgga agttgcaata 3825 aaaattcctt atgaaatata tggttttcat ctgtaattga aggaaatcat agaaagtttg 3885 ctgaaagcaa agggctaagc ttatgaagga atgcctcctt tgttacacac tcaagaattt 3945 gtcagcacac aattaattgc agccatagta cctttttgcg taatgtttgg gatattcagt 4005 agcccaggat tgctacaaaa aggtcctttg agaaaattaa tttgtgcttg cttttatccc 4065 ctctcagaaa gacatcacta aaggcccatt aaaa atctgg ccctaaaagt tcaacttttg 4125 tagagtttat tgttcagaga ggtttaatcc tatgtggtag tctatataag tgatgtatga 4185 gttgagttat gtaaattttg tcattgtagt gtacatggag tgatcatttt actaacataa 4245 atattttcta tgtgtgtttc agtggatgac aatcgagcag cagaagaatg gtgtgcctac 4305 cctttaatgc tgcagtttaa gagaacttgt attgtgtcat ttcagattgt aggctgagag 4365 ttgtaaatag tgaaaatttg agtacttcta ttatttgttt tggttagaaa gtgaatttaa 4425 aaaacaaacc aaactctaaa ctttctcaga ttaaaagtcc tgagacctga agattgtaat 4485 attcatgtct gtgaagcttt taaacattac acttgagatc agtcatgact tgatattcag 4545 gtaaattttc ttttccaaga agcttttgaa taagcatatt tcctccaaag gtctctctct 4605 ttctctctct ttttttgagt gtagattatt ttaaagcact aattgcatta cattggtaac 4665 tgcaatataa aatagcctgattgattcattgattcatttattgattagtattgattgattgattgattcattgattagtattgattagttagtattgattagttagtattgattagattagttagttagtt <210> 39 <211> 4236 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1121) .. (2941) <400> 39 gttctagatc gcgagcggcc gccctttttt ttttttttta aaaaaagtca tatttgttat 60 ttgtctaatc ttgtgtggag aaagacagca tgtaggaaag ccactgggtg acattctggc 120 aaattccatg gttctgtctt gaagtgaagc ctagtagttt ttcaggaggt cctttgcacc 180 acatcttgca ttgtcattaa caattttatg tctctaaaag gtaatacggg ttatttttta 240 atgggtatgg agtttccatt tgggaagatg aaaagttctc taaatgcatg atggtgatgg 300 ttgtacaaaa gtatgaatgt acttatgcca cttaattgta catttaaaaa gggttacaat 360 gataaatatt atgtatattt taccacaata aaaaagaaaa aaaattttaa aaaaaaaaaa 420 aaaggtaatt atttcaccta gacctatgtg tgtgagtgtt gtcgctttgt gtgattttct 480 gttggagttg aataacatga gctataacag aaaacatact gaggtttgtg aatgtgacat 540 aggaaggcag ttctagtgta gcagttaaag atggtcaact ctggagccag actgcttggc 600 ttcatgttct ggttccattg ctttcttgct gtctgacctt ggataagttt cttagccttt 660 cttggcctca gttttccaat tgtgaagtag agataatgat cgtacttatt tcatggaatt 720 actgtgagga ttagatgagc tattgttaaa aaaaaatact taaaatggct gggcacagtg 780 gctcacgcat gtaatcccgg cactttggga gaccgaggtg ggcagatcac ctgaggtcag 840 gagttagaga c cagcctggc caacatggtg aaacccatct ctactaaaaa tacaaaaatt 900 agccaggcgt ggtggcgggt gcctgtagtc ccagctactt gggaggctga ggcaggagaa 960 tcacttgaac ccaggaggtg gaggttgcag tgagctgaga ctgtgccact gcactccagc 1020 ctggacaaca gagcaaaaat ccatctcaaa aaaaaaaaaa aaaaaaaaag cttaaaacat 1080 gttctgtcat atggtaagcg ctaaatgaat ggacccctag acc tgg gtt cta aac 1135 Thr Trp Val Leu Asn 1 5 agt gtt act gat ata aat aca ctt gcg aat gta aac ata aat cgg aca 1183 Ser Val Thr Asp Ile Asn Thr Leu Ala Asn Val Asn Ile Asn Arg Thr 10 15 20 ttt gtt ttt gct ttt ttt tta aag gta aaa gaa ata gga gat tac ttt 1231 Phe Val Phe Ala Phe Phe Leu Lys Val Lys Glu Ile Gly Asp Tyr Phe 25 30 35 aaa caa cac ctt ttg cag tcc agg cac aga gga gca ttt gaa ttg gct 1279 Lys Gln His Leu Leu Gln Ser Arg His Arg Gly Ala Phe Glu Leu Ala 40 45 50 tat act ggt ttt gtg aaa ctc act gaa gta cta aac agg tgc cca aat 1327 Tyr Thr Gly Phe Val Lys Leu Thr Glu Val Leu Asn Arg Cys Pro Asn 55 60 65 gtg agt ctg caa aag ctg cca gaa cag tgg cta tgg agt gtt tta gag 1375 Val Ser Leu Gln Lys Leu Pro Glu Gln Trp Leu Trp Ser Val Leu Glu 70 75 80 85 gaa att aaa tgc agt gat cct tca tct aaa ctc tgt gct aca agg cgc 1423 Glu Ile Lys Cys Ser Asp Pro Ser Ser Lys Leu Cys Ala Thr Arg Arg 90 95 100 agt gct gga att cct ttc tac ata cag gca ctg ttg gca tct gaa cca 1471 Ser Ala Gly Ile Pro Phe Tyr Ile Gln Ala Leu Leu Ala Ser Glu Pro 105 110 115 aag aaa ggc aga atg gat ttg ttg aaa ata aca atg aaa gag tta atc 1519 Lys Lys Gly Arg Met Asp Leu Leu Lys Ile Thr Met Lys Glu Leu Ile 120 125 130 tct ttg gct ggg cct aca gat gac ata cag agt aca gtc ccc cag gtt 1567 Ser Leu Ala Gly Pro Thr Asp Asp Ile Gln Ser Thr Val Pro Gln Val 135 140 145 cat gct tta aat atc ctt aga gca ttg ttc aga gat acg cgc ctg gga 1615 His Ala Leu Asn Ile Leu Arg Ala Leu Phe Arg Asp Thr Arg Leu Gly 150 155 160 165 gaa aat att att cct tat gtt gct gat gga gct aag gct gca att ctg 1663 Glu Asn Ile Ile Pro Tyr Val Ala Asp Gly Ala Lys Ala Ala Ile Leu 170 175 180 ggt ttt aca tca ccg gtc tgg gca gtg cga at aca ctt ctc 1711 Gly Phe Thr Ser Pro Val Trp Ala Val Arg Asn Ser Ser Thr Leu Leu 185 190 195 ttt agt gcc ttg atc aca aga att ttt gga gtt aaa agg gca aag gat 1759 Phe Ser Ala Leu Ile Thr Arg Ile Phe Gly Val Lys Arg Ala Lys Asp 200 205 210 gaa cat tcc aaa aca aat aga atg aca ggg aga gag ttt ttc tct cgt 1807 Glu His Ser Lys Thr Asn Arg Met Thr Gly Arg Glu Phe Phe Ser Arg 215 220 225 ttc cca gaa ctc tat cct ttt ctt ctc aaa cag ttg gaa act gta gcc 1855 Phe Pro Glu Leu Tyr Pro Phe Leu Leu Lys Gln Leu Glu Thr Val Ala 230 235 240 245 aat aca gta gac agt gat atg gga gaa cca aat cgt cat cca agc atg 1903 Asn Thr Val Asp Ser Asp Met Gly Glu Pro Asn Arg His Pro Ser Met 250 255 260 ttt ctc tta ctt ttg gtg ttg gag aga ctc tac gct tcc ccg atg gat 1951 Phe Leu Leu Leu Leu Val Leu Glu Arg Leu Tyr Ala Ser Pro Met Asp 265 270 275 ggt act tct tct gct ctc agc atg gga cct ttt gtt ccc ttc att atg 1999 Gly Thr Ser Ser Ala Leu Ser Met Gly Pro Phe Val Pro Phe Ile Met 280 285 290 agg tgt ggt cac tca cct gtc tac cac tcc cgt gaa atg gca gct cgt 2047 Arg Cys Gly His Ser Pro Val Tyr His Ser Arg Glu Met Ala Ala Arg 295 300 305 gcc ttg gtc cca ttt gtt atg ata gat cac att cct aat acc att cga 2095 Ala Leu Val Pro Phe Val Met Ile Asp His Ile Pro Asn Thr Ile Arg 310 315 320 325 act ctg ttg tcc aca ctc ccc agc tgc act gac cag tgt ttc cgg caa 2143 Thr Leu Leu Ser Thr Leu Pro Ser Cys Thr Asp Gln Cys Phe Arg Gln 330 335 340 aac cac att cat ggg aca ctt ctc cag gtt ttt cat ttg ttg caa gcc 2191 Asn His Ile His Gly Thr Leu Leu Gln Val Phe His Leu Leu Gln Ala 345 350 355 tac tca gac tcc aaa cac gga acg aat tca gac ttc cag cac gag ctg 2239 Tyr Ser Asp Ser Lys His Gly Thr Asn Ser Asp Phe Gln His Glu Leu 360 365 370 act gac atc act gtt tgt acc aaa gcc aaa ctc tgg ctg gcc aag agg agg 2287 Thr Asp Ile Thr Val Cys Thr Lys Ala Lys Leu Trp Leu Ala Lys Arg 375 380 385 caa aat cca tgt ttg gtg acc aga gct gta tat att gat att ctc ttc 2335 Gln Asn Pro Cys Leu Val Thr Arg Ala Val Tyr Ile Asp Ile Leu Phe 390 395 400 405 cta ttg act tgc tgc ctc aac aga tct gca aag gac aac cag cca gtt 2383 Leu Leu Thr Cys Cys Leu Asn Arg Ser Ala Lys Asp Asn Gln Pro Val 410 415 420 ctg gag agt ctt ggc ttc tgg gag gaa gtc aga ggg att atc 2431 Leu Glu Ser Leu Gly Phe Trp Glu Glu Val Arg Gly Ile Ile Ser Gly 425 430 435 tca gag ctg ata acg gga ttc cct tgg gcc ttc aag gtg cca ggc ctg 2479 Ser Glu Leu Ile Thr Gly Phe Pro Trp Ala Phe Lys Pro Gly Leu 440 445 450 ccc cag tac ctc cag agc ctc acc aga cta gcc att gct gca gtg tgg 2527 Pro Gln Tyr Leu Gln Ser Leu Thr Arg Leu Ala Ile Ala Ala Val Trp 455 460 465 gcc gcg gca gcc aag agt ggag cgg gag acg aat gtc ccc atc tct 2575 Ala Ala Ala Ala Lys Ser Gly Glu Arg Glu Thr Asn Val Pro Ile Ser 470 475 480 485 ttc tct cag ctg tta gaa tct gcc ttc cct gaa gtg cgc tca cta aca Leu Phe Ser Leu Glu Ser Ala Phe Pro Glu Val Arg Ser Leu Thr 490 495 500 ctg gaa gcc ctc ttg gaa aag ttc tta gca gca gcc tct gga ctt gga 2671 Leu Glu Ala Leu Leu Glu Lys Phe Leu Ala Ala Ala Ser Gly Leu Gly 5 05 510 515 gag aag ggc gtg cca ccc ttg ctg tgc aac atg gga gag aag ttc tta 2719 Glu Lys Gly Val Pro Pro Leu Leu Cys Asn Met Gly Glu Lys Phe Leu 520 525 530 ttg ttg gcc atg tag gcaaat c ttc tgc aag ata ctg 2767 Leu Leu Ala Met Lys Glu Asn His Pro Glu Cys Phe Cys Lys Ile Leu 535 540 545 aaa att ctc cac tgc atg gac cct ggt gag tgg ctt ccc cag acg gag 2815 Lys Ile Leu His Cys M Gly Glu Trp Leu Pro Gln Thr Glu 550 555 560 565 cac tgt gtc cat ctg acc cca aag gag ttc ttg atc tgg acg atg gat 2863 His Cys Val His Leu Thr Pro Lys Glu Phe Leu Ile Trp Thr Met Asp 570 575 575 580 att gct tcc aat gaa agg ttt gcc ccc aaa acc tcc tgt gca acc ttg 2911 Ile Ala Ser Asn Glu Arg Phe Ala Pro Lys Thr Ser Cys Ala Thr Leu 585 590 595 gta aga tgt atg gtc cca tca gtc att atg taatgaactt gcacacaatc 29 Met Val Pro Ser Val Ile Met 600 605 ctgccctcag gtctcaggtc ctgtatttca ttctaaacct cagcctaaga gttctaaact 3021 caagcaatag aatgatgtca gtgatttgca ttaataacca aaaggtaatt gcttccggag 3081 gc atttttgt aaccaggagg tagagatttt cagtattcac ctctgcatgg attacagact 3141 atctgcaaaa accggtgtat gaaatatgtc tgattgtaat tttgtgttgt ttttttgttt 3201 gtttattttt ctagatctga aattcagagt gtagctctga gacttgcttc caaagtcatt 3261 tcccaccaca tgcagacatg tgtggagaac agggaattga tagctgctga gctgaagcag 3321 tgggttcagc tggtcatctt gtcatgtgaa gaccatcttc ctacagagtc taggctggcc 3381 gtcgttgaag tcctcaccag tactacacca cttttcctca ccaaccccca tcctattctt 3441 gagttgcagg atacacttgc tctctggaag tgtgtcctta cccttctgca gagtgaggag 3501 caagctgtta gagatgcagc cacggaaacc gtgacaactg ccatgtcaca agaaaatacc 3561 tgccagtcaa cagagtttgc cttctgccag gtggatgcct ccatcgctct ggccctggcc 3621 ctggccgtcc tgtgtgatct gctccagcag tgggaccagt tggcccctgg actgcccatc 3681 ctgctgggat ggctgttggg agagagtgat gacctcgtgg cctgtgtgga gagcatgcat 3741 caggtggaag aagactacct gtttgaaaaa gcagaagtca acttttgggc cgagaccctg 3801 atctttgtga aatacctctg caagcacctc ttctgtctcc tctcaaagtc cggctggcgt 3861 cccccaagcc ctgagatgct ctgtcacctt caaaggatgg tgtcagagca gtgccacctc 3921 ctgtctca gt tcttcagaga gcttccacca gctgctgagt ttgtgaagac agtggagttc 3981 acaagactac gcattcaaga ggaaaggact ttggcttgct tgaggctgct ggcctttttg 4041 gaaggaaagg aaggggaaga caccctagtt ctcagtgttt gggactctta tgcagaatcg 4101 aggcagttaa ctcttccaag aacagaagcg gcatgttgaa gaaaatctgg gggattggga 4161 tgggggtatg tgtggatttt tcctccacta aatctgcagg aaacatgttg aacataaatt 4221 caaaaatttt atccc 4236 <210> 40 <211> 3808 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (248) .. (2584) <400> 40 cttctccgag tggggacatt gctgacaatc ccggcttccc gaggcggcta agaacaggca 60 gtttgtgtcg gctggctgca gatacccaga ggcacaaaga gaccgaagcc acccggaggg 120 acccacggac ggacagatgg taggcgcgaa cccgagagga ccggcggagg ctgagcaccg 180 agagccgcca aggaagagaa actaaccaca gccaagttac cccgccggct ttccttcgct 240 gcgctaa gga atg aaa ccc ttc cag ctc gat ctg ctc ttc gtc tgc ttc 289 Gly Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe 1 5 10 ttc ctc ttc agt caa gag ctg ggc ctc cag aag aga gga tgc tgt ctg 337 Phe Leu Phe Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cysu 25 30 gtg ctg ggc tac atg gcc aag gac aag ttt cgg aga atg aat gaa ggc 385 Val Leu Gly Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly 35 40 45 caa gtc tat tcc ttc agc cag cag ccc cag gtg gtg gtg tcg 433 Gln Val Tyr Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser 50 55 60 gga cag cca gtg acg cta ctt tgc gcc atc ccc gaa tac gat ggc ttc 481 Gly Gln Pro Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe 65 70 75 gtt ctg tgg a tc aag gac ggc ttg gct ctg ggt gtg ggc agg gac ctc 529 Val Leu Trp Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu 80 85 90 tca agt tac cca cag tac ctg gtg gta ggg aac cac gctca Ser Ser Tyr Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu 95 100 105 110 cac cac ctg aag atc ctg agg gca gag ctg caa gac gat gcg gtg tac 625 His His Leu Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr 115 120 125 gag tgc cag gcc atc cag gcc gcc atc cgc tcc cgc ccc gca cgc ctc 673 Glu Cys Gln Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu 130 135 140 aca gtc ctg gtg gcc gct g ccc gtc atc ctg ggg ggc cct gtg 721 Thr Val Leu Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val 145 150 155 atc agc ctg cgt gcg ggg gac cct ctc aac ctc acc tgc cac gca gac 769 Ile Ser Leu Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp 160 165 170 aat gcc aag cct gca gcc tcc atc atc tgg ttg cga aag gga gag gtc 817 Asn Ala Lys Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val 175 180 185 190a tc aat ggg gcc acc tac tcc aag acc ctg ctt cgg gac ggc aag cgg 865 Ile Asn Gly Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg 195 200 205 gag agc atc gtc agc acc ctc ttc atc tcc cct ggt gac gag aat 913 Glu Ser Ile Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn 210 215 220 ggc cag agc atc gtg tgt cgt gcc acc aac aaa gcc atc ccc gga gga 961 Gly Gln Ser Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly 225 230 235 aag gag acg tcg gtc acc att gac atc cag cac cct cca ctg gtc aac 1009 Lys Glu Thr Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn 240 245 250 ctc tcg gtg gag cca cag cca gtg ctg gag gac aac gtc gtc act ttc 1057 Leu Ser Val Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe 255 260 265 270 cac tgc tct gca aag gcc aac cca gct gtc acc cag tac agg tgg gcc 1105 His Cys Ser Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala 275 280 285 aag cgg ggc cag atc atc aag gag gca tct gga gag gtg tac agg acc 1153 Lys Arg Gly Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr 290 295 300 aca gtg gac tac acg tac ttc tca gag ccc gtc tcc tgt gag gtg acc 1201 Thr Val Asp Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr 305 310 315 aac gcc ctg ggc agc acc aac ctc agc cgc acg gtt gac gtc tac ttt 1249 Asn Ala Leu Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe 320 325 330 ggg ccc cgg atg acc aca gaa ccc caa tcc ttg ctc gtg gat ctg ggc 1297 Gly Pro Arg Met Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly 335 340 340 345 350 tct gat gcc atc ttc agc tgc gcc tgg acc ggc aac cca tcc ctg acc 1345 Ser Asp Ala Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr 355 360 365 atc gtc tgg atg aag cgg ggc tcc gga gtg gtc ctg agc aat gag aag 1393 Ile Val Trp Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys 370 375 380 acc ctg acc ctc aaa tcc gtg cgc cag gag gac gg gtg 1441 Thr Leu Thr Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val 385 390 395 tgc cgg gct gtg gtg ccc cgt gtg gga gcc ggg gag aga gag gtg acc 1489 Cys Arg Ala Val Val Pro Arg Val Gly Ala G ly Glu Arg Glu Val Thr 400 405 410 ctg acc gtc aat gga ccc ccc atc atc tcc agc acc cag acc cag cac 1537 Leu Thr Val Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His 415 420 425 430 gcc ctc cac ggc gag aag ggc cag atc aag tgc ttc atc cgg agc acg 1585 Ala Leu His Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr 435 440 445 ccg ccg ccg gac cgc atc gcc tgg tcc tgg aag gag ag gtt 33 Pro Pro Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu 450 455 460 tcg ggc aca tcg ggg cgc tat acg gtg gag acc atc agc acc gag gag 1681 Ser Gly Thr Ser Gly Arg Tyr Thr Val Val Glu Thr Ile Ser Thr Glu Glu 465 470 475 ggc gtc atc tcc acc ctg acc atc agc aac atc gtg cgg gcc gac ttc 1729 Gly Val Ile Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe 480 485 490 cag acc atc tac aac tgc acg gcc tac agc ttc ggc tcc gac act 1777 Gln Thr Ile Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr 495 500 505 510 gag atc atc cgg ctc aag gag caa ggt tcg gaa atg aag tcg gga gcc 1825 Glu Ile Arle Le u Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala 515 520 525 ggg ctg gaa gca gag tct gtg ccg atg gcc gtc atc att ggg gtg gcc 1873 Gly Leu Glu Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala 530 540 gta gga gct ggt gtg gcc ttc ctc gtc ctt atg gca acc atc gtg gcg 1921 Val Gly Ala Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala 545 550 555 ttc tgc tgt gcc cgt tcc cag aga aat gtcc gtg tca gcc 1969 Phe Cys Cys Ala Arg Ser Gln Arg Asn Leu Lys Gly Val Val Ser Ala 560 565 570 aaa aat gat atc cga gtg gaa att gtc cac aag gaa cca gcc tct ggt 2017 Lys Asn Asp Ile Arg Val Glu Ile His Lys Glu Pro Ala Ser Gly 575 580 585 590 cgg gag ggt gag gag cac tcc acc atc aag cag ctg atg atg gac cgg 2065 Arg Glu Gly Glu Glu Glu His Ser Thr Ile Lys Gln Leu Met Met Asp Arg 595 600 605 ggt gaa ttc cag caa gac tca gtc ctg aaa cag ctg gag gtc ctc aaa 2113 Gly Glu Phe Gln Gln Asp Ser Val Leu Lys Gln Leu Glu Val Leu Lys 610 615 620 gaa gag gag aaa gag ttt cag aac ctg aag gac ccc acc aatgg Glu Glu Glu Lys Glu Phe Gln Asn Leu Lys Asp Pro Thr Asn Gly Tyr 625 630 635 tac agc gtc aac acc ttc aaa gag cac cac tca acc ccg acc atc tcc 2209 Tyr Ser Val Asn Thr Phe Lys Glu His His Ser Thr Pro Thr Ile Ser 640 645 650 ctc tcc agc tgc cag ccc gac ctg cgt cct gcg ggt aag cag cgt gtg 2257 Leu Ser Ser Cys Gln Pro Asp Leu Arg Pro Ala Gly Lys Gln Arg Val 655 660 665 670 ccc aca ggc atg tacttccc atc tac agc acc ctg agc ggc cag 2305 Pro Thr Gly Met Ser Phe Thr Asn Ile Tyr Ser Thr Leu Ser Gly Gln 675 680 685 ggc cgc ctc tac gac tac ggg cag cgg ttt gtg ctg ggc atg ggc agc Leu Asp Tyr Gly Gln Arg Phe Val Leu Gly Met Gly Ser 690 695 700 tcg tcc atc gag ctt tgt gag cgg gag ttc cag aga ggc tcc ctc agc 2401 Ser Ser Ile Glu Leu Cys Glu Arg Glu Phe Gln Arg Gly Ser Leu Ser 705 710 gac agc agc tcc ttc ctg gac acg cag tgt gac agc agc gtc agc agc 2449 Asp Ser Ser Ser Phe Leu Asp Thr Gln Cys Asp Ser Ser Val Ser Ser 720 725 730 agc ggc aag cag gat ggc tat gtg ag gttc ac cc agc aag gct 2497 Ser Gly Lys Gln Asp Gly Tyr Val Gln Phe Asp Lys Ala Ser Lys Ala 735 740 745 750 tct gct tcc tcc tcc cac cac tcc cag tcc tcg tcc cag aac tct gac 2545 Ser Ala Ser Ser Ser His His Ser Gln Ser Ser Ser Gln Asn Ser Asp 755 760 765 ccc agt cga ccc ctg cag cgg cgg atg cag act cac gtc taaggatcac 2594 Pro Ser Arg Pro Leu Gln Arg Arg Met Gln Thr His Val 770 775 acaccgcgg tggggacggg cggg ggtgggtgggtggg caccagaatt ggccacttcc aggacagcct cccagcgcct 2714 ctgccactgc cttccttcga agctctgatc aagcacaaat ctgggtcccc aggtgctgtg 2774 tgccagaggt gggcgggtgg ggagacagac agaggctgcg gctgagtgcg ctgtgcttag 2834 tgctggacac ccgtgtcccc ggccctttcc tggaggcccc tctaccacct gctctgccca 2894 caggcacaag tggcagctat aactctgctt tcatgaaact gcggtccact ctctggtctc 2954 tctgtgggct ctacccctca ctgaccacaa gctctaccta cccctgtgcc tgtgctccca 3014 tacagccctg gggagaaggg gatgacgtct tcccagcact gagctgcccc agaaaccccg 3074 gctccccact gctgctcata gcccataccc tggaggttga caagccagaa atg gccttgg 3134 ctaaaggagc ctctctctca ccaggctggc cgggagccca cccccaattt gtttggtgtt 3194 ttgtgtccat actcttgcag ttctgtcctt ggacttgatg ccgctgaact ctgcggtggg 3254 accggtcccg tcagagcctg gtgtactggg gggagggagg gaggagggag cctgtgctga 3314 cggagcacct cgccgggtgt gcccctcctg ggctgtgtga ccccagcctc cccacccacc 3374 tcctgctttg tgtactcctc ccctccccct cagcacaatc ggagttcata taagaagtgc 3434 gggagcttct ctggtcaggg ttctctgaac acttatggag agagtgcttc ctgggaagtg 3494 tggcgtttga aggggctgga gggcaggtct ttaagatggc gagactgccc ttctcagctg 3554 ataaacacaa gaacggcgat cctgtcttca gtaaggctcc acgagaagag aggaagtata 3614 tctacacctc aaccctccta gtcaccacct gaaataaatg ttagggacac tactccaaca 3674 tgtttgttct gttcttttgt tcctacaaag ccacaggaag aacccaagag ctcatagaat 3734 gcgttgggaa cccaaggttc tctgccctcc tttgattcaa tcatcctaga caataaaggc 3794 agttgatagc tctg 3808 <210> 41 <211> 4742 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (735) <400> 41 gta gca gtg cag act gcc tca aaa caa gtt gat ggt gat tat gtt gtg 48 Val Ala Val Gln Thr Ala Ser Lys Gln Val Asp Gly Asp Tyr Val Val 1 5 10 15 tct gaa tgg agt gaa att ata gaa ttc tgc acc gca gac tat tca aaa 96 Ser Glu Trp Ser Glu Ile Ile Glu Phe Cys Thr Ala Asp Tyr Ser Lys 20 25 30 gtt cat cta aca caa ttg ttg gag aag gct gaa gtg att gca gga cgc 144 Val His Leu Thr Gln Leu Leu Glu Lys Ala Glu Val Ile Ala Gly Arg 35 40 45 atg ctt aag ttt tct gtt ttt tat cgt aat cag cac aaa gaa tat ttt 192 Met Leu Lys Phe Ser Val Phe Tyr Arg Asn Gln His Lys Glu Tyr Phe 50 55 60 gac tat gtt cga gaa cat cat ggg aat gct atg cag cca tct gtc aag 240 Asp Tyr Val Arg Glu His His Gly Asn Ala Met Gln Pro Ser Val Lys 65 70 75 80 gat aac agt ggt agc cat ggc tct cct atc agt gga aaa tta gaa ggc 288 Asp Asn Ser Gly Ser His Gly Ser Pro Ile Ser Gly Lys Leu Glu Gly 85 90 95 atc ttc ttc agc tgc agc act gaa ttc aat act gga aag cca ccc cag 336 Ile Phe Phe Ser Cys Ser Thr Glu Phe Asn Thr Gly Lys Pro Pro Gln 100 105 110 gat tca cct tat gga aga tac agg ttt gag att gcc gca gaa aaa ctt 384 Asp Ser Pro Tyr Gly Arg Tyr Arg Phe Glu Ile Ala Ala Glu Lys Leu 115 120 125 ttt aac ccc aat act aac tta tac ttt ggg gac ttc tac tgt atg tac 432 Phe Asn Pro Asn Thr Asn Leu Tyr Phe Gly Asp Phe Tyr Cys Met Tyr 130 135 140 act gct tat cat tat gtg att ctt gtt att gct cct gtg gga tca cca 480 Thr Ala Tyr His Tyr Val Ile Leu Val Ile Ala Pro Val Gly Ser Pro 145 150 155 160 gga gat gaa ttt tgt aag cag cgc ctt cct caa cta aat tct aag gat 528 Gly Asp Glu Phe Cys Lys Gln Arg Leu Pro Gln Leu Asn Ser Lys Asp 165 170 175 aat aaa ttt ttg acc tgt aca gaa gaa gat ggg gtg ctg gtt tac cac 576 Asn Lys Phe Leu Thr Cys Thr Glu Glu Asp Gly Val Leu Val Tyr His 180 185 190 cat gcc cag gat gtc att tta gaa gtc att tac act gac cct gtg gat 624 His Gln Asp Val Ile Leu Glu Val Ile Tyr Thr Asp Pro Val Asp 195 200 205 ctt tct ctg ggc acc gtg gca gaa atc act ggt cat cag ctc atg agt 672 Leu Ser Leu Gly Thr Val Ala Glu Ile Thr Gly His Gln Leu Met Se r 210 215 220 ttg tct act gca aat gca aag aaa gat ccc agc tgc aaa acc tgt aat 720 Leu Ser Thr Ala Asn Ala Lys Lys Asp Pro Ser Cys Lys Thr Cys Asn 225 230 235 240 atc agt gtt gga cgt taatgcccac ttttctgtt cttcattt 775 Ile Ser Val Gly Arg 245 cccttaggag cattggtcct ctgttgtcca tttttatcac cagatgtttt ccactgaagc 835 atgcacatgc cactgtcacc aaaacaaaca actaccactt tccaaatttc attcagaacc 895 attttagtgt tttcctattc cctacccctc ccactacttt caatgatgaa ataccctaag 955 ttaagttctc cttttgacac tttattgcct agatgctgca atgtttttat gtttccttta 1015 tgccaaacat aacaaaacag ttatatagac tgctttagca aagtacacaa taatggctta 1075 taaatggtgt ttaaatatgc attcatttta atctactgaa caaatattgg gataactcca 1135 aaccgcatga aagggtgtaa ttgcagcatg agttaaatct tgaagcctag aattgtcagc 1195 acttccaact tcttgtttga cagtgttatt tatgttattt atattagcta acaggaaaca 1255 actactgtgt ttcaacataa taaatataat agaaaaatat tttatttgta ttgttgtata 1315 aaatatttac aatcatatag aatatataga gttacatttt aatagcaact gtgtacatgt 1375 cacgaaacca tttcccttat caaagatgta atttgt aaac ctcaaatagt tgtgtatctg 1435 tcctgttaga agtagatgac ttcaattaaa caaatttatg aaggacatta ttctgattca 1495 taaaagttat aaaatattag gtaaatacag agaaaacaat aagcctctga aataagtctg 1555 tttctgaaat agtcaatagt cttcccatcc aaactataag agaatgtgaa tttcttcaac 1615 atcatactta aacattacag aaaatagaaa tacaaacaag gttggtacat gagagaaaat 1675 gttgaccttt tacttccttt tacaaaaatg aaaataataa acatgttttc gtataaaata 1735 acacaaaatg atatacactg aagttgatga agcaaataaa tattctggct tctttttcaa 1795 ggtatcaggg caaacaattt ccaaactttt cattttgtac agaaggatga ataactacag 1855 ctcatgggaa atgttttgac tttacaaagt atagatgttg gaacattaag aaaaatgtat 1915 attcccaatg aaaaaatagt tatatcatct tatagtaaac caaaagatta gcaataatac 1975 tatggacaca ttagattata tactacagac acatatctat ccaaaatacc tattttaaat 2035 ttttaataca atattttatt ttaatataaa catctgtcag ttatagacaa agataataat 2095 tcacaaagta catgctatca gaatgaactt tggtaaccag aaatgtaaaa tttcaaataa 2155 cggataaaat aatgtgttat ttttatagag aaagaaaaaa aatagcaaca caatctagtt 2215 tattttaggg tactgagagc ctagcagact taaaggacaa ggtagtaaat gttttatcac 2275 tcaaaaatcc attagaagtt tcaaataaat tgctttcttg ctagctgtat tccttcctac 2335 ttgaaaagcg aatttctttt cctcctatga ttgatttttt aaaatcatgc tcttttccat 2395 acatcaacat aaacagtctt tggatactaa ataaactttc cctaacaagt gtcctagcta 2455 tgttatttag atttgataaa atattagaca tttttaaaaa tacttgtatt gactatgagt 2515 tttctgcttg gcatggagga cactgaattt tttcccaatt atatggctac ctgttgtatt 2575 cttccccccg tttaaatccc ttctccttgt atataattaa acttgctatt ccttcttaaa 2635 aacagctaat actaccacta aagtgcttcc attttcattg tgtcaaaact acttagcaag 2695 gatggcagag gaaaataaac tttactttat atcatgggtg aaagtgatca taacatttcc 2755 tgaacctcaa atagttttgg ccacatcttg cttgctgatg aggacctcta atagtctcag 2815 tttggctttt atgtgcttat attcataata ctcatctgcc attggtatcc tatcttcctt 2875 ttgtggactt ctgcaaaaca aaaatacatt tgttagttca caatgagtca agtcattatt 2935 taaacattct tttataattc atacatgaga aagtatatga ggacctctaa tagtctcagt 2995 ttggctttta tgtgcttata ttcataatac tcatctgcca ttggtatcct atcttccttt 3055 tgtggacttc tgcaaaacaa aaatacattt gttagttcac aatgag tcaa gtcattattt 3115 aaacattctt ttataattca tacatgagaa agtatactgt aacagcctcc acttggtttt 3175 tgcatcatgt cttcttttcc ttccctttca ccttcattca ctccttcttc catgtgttac 3235 taagtttcta aataatagta acctttgaaa acttgaatgt cataagtgtt ttgcaaatat 3295 gtggtctagt gcttagactt acaacaaagg ggtcagtgaa aagatctaag gagaagcaaa 3355 caaacaagaa acagaacttt caaggcattc tttgtccagt cattcttcca ttatttgcca 3415 cacccctaca gctgtacaaa atgatcagcc ctaatacagt tgttaaaaat attaacctga 3475 aaatactaca ggaatttcat tataaaaata acataaacct atggtaacaa gaaaagcatt 3535 tagggtctgt cttacaaact tgaaacgttt ccagattttc ttgtaattat aatacctatc 3595 tctgctaata tatagtagaa ccactgagct gttccttgat tgaagtaatt gacaagagtc 3655 taaattgtgg tggttctctt ctgtacacta attctactaa ggctagacat gtaacaatgc 3715 atagattttt atacatatgc agcatactct tgctgtttac ttggaagaat aacttggtaa 3775 tatcaggagt taaaaccatt tgccttccca caaaaatatg ttgtcaggaa acgttttcta 3835 aagggaaaaa ttgcgacagg gtctcagaag gctcttgttt tcttggttaa taagatagcc 3895 aatcgttttg aaaacatttc cacccacgac tttgaaattc aaggggtaga g gacacagat 3955 atagtcacca caattacaac tgaatataac cacaagtatt ctctaatgtt agtatggctg 4015 aaaccaggta aatagcatat atttaatgtt ttatctttag ctccctttta tttttcccag 4075 tagtgataaa gagatatttc tatctcttac caaataaaaa acaagctaat ctatacaaat 4135 taagaatata gtatctactt gtatttcaac actatttatt gccctgcaat ttctagtaca 4195 gaactcagaa cagtatacaa atccatagac agcattcttc ttaactgttg tctaaattat 4255 ataacatata tctttgcctc cattctgtgt tatgagtcaa acttatcatg gctggatgtc 4315 tgaataccac cttaatttgt ataaatagat ctaagtaaag aaattgtcta attattacag 4375 agaaacatta ataatcaatt atgtaatttt ccgtagtttt gcatattcca ttttggctaa 4435 taagagtgct ttgaggccgg gcacagtggc tcacgcctgt aatcccagca ctttgagagg 4495 ccgaggcggg cggatcacaa ggtcaggaga ttgagaccat cctggctaac atggtgaaac 4555 cctgtctcta ctaaaaatat aaaaacttag ccacgcgtgg tggcgtacgc ctgtagtccc 4615 agctacttgg gaggctgagg caggagaatg gcgtgaaccg tgaacccagg aggcggagct 4675 tgcagtgagc cgagatcgcg tcactgcact ccagcccagg tgacagagtg agactccgtc 4735 tcaaaag 4742 <210> 42 <211> 4580 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (72) .. (2672) <400> 42 ggtttttttg gcatctgaac tggaagactt tgaatgcttc ctcctaagac tgagccgtat 60 tggaggtgta a tac agg ata ccc tcc ctg ttc aaa act aca aga cca aag 110 Tyr Arg Ile Pro Ser Leu Phe Lys Thr 5 gg atg attcc 1 aat tca ttc tct att gtt tgg agc aca 158 Lys Val Gly Ile Ser Ile Leu Asn Ser Phe Ser Ile Val Trp Ser Thr 15 20 25 gtc tgc agc atc ttc ttt atg tct acc ttg act gtt aca aat ccc aaa 206 Val Cys Ser Ile Phe Phe Met Ser Thr Leu Thr Val Thr Asn Pro Lys 30 35 40 45 ctg atc ttc cag gct agc ctt gca aat gct cag att ttg att ccc acc 254 Leu Ile Phe Gln Ala Ser Leu Ala Asn Ala Gln Ile Leu Ile Pro Thr 50 55 60 aat cag gcc agt gta agc agt atg cta ttg gaa gga cat acc ctc ctg 302 Asn Gln Ala Ser Val Ser Ser Met Leu Leu Glu Gly His Thr Leu Leu 65 70 75 gcc ctt gct act aca atg tat tct cct ggg ggt gtc agt cag gtt gtt 350 Ala Leu Ala Thr Thr Met Tyr Ser Pro Gly Gly Val Ser Gln Val Val 80 85 90 cag aat gaa gaa aat gaa aac tgt ttg aag aaa gtg gat ccc cag cta 398 Gln Asn Glu Glu As n Glu Asn Cys Leu Lys Lys Val Asp Pro Gln Leu 95 100 105 ttg aag atg gca tta act cct tac ccc aag cta aaa act gct ctc ttc 446 Leu Lys Met Ala Leu Thr Pro Tyr Pro Lys Leu Lys Thr Ala Leu Phe 110 115 120 125 cca cag tgc act cct cct agt gtc ctg cca tct gat att aca atc tac 494 Pro Gln Cys Thr Pro Pro Ser Val Leu Pro Ser Asp Ile Thr Ile Tyr 130 135 140 cac ctt att cag tca tta tca ccc ttt gat cct agc aga ttg ttt ggc 542 His Leu Ile Gln Ser Leu Ser Pro Phe Asp Pro Ser Arg Leu Phe Gly 145 150 155 tgg cag tct gct aac aca cta gct ata gga gat gca tgg agt cat ctc 590 Trp Gln Ser Ala Asn Thr Leu Ala Ile Gly Asp Ala Trp Ser His Leu 160 165 170 cca cat ttc tct agc cct gac ctg gtt aat aaa tat gct ata gtg gaa 638 Pro His Phe Ser Ser Pro Asp Leu Val Asn Lys Tyr Ala Ile Val Glu 175 180 185 cgt ctg aat ttt gct tat tat tta cat aat ggg cgg cca tca ttt gca 686 Arg Leu Asn Phe Ala Tyr Tyr Leu His Asn Gly Arg Pro Ser Phe Ala 190 195 200 205 ttt ggt act ttt ctg gtc cag gaa tta atc aag agc aag act ccc aag 734 Phe Gly Thr Phe Leu Val Gln Glu Leu Ile Lys Ser Lys Thr Pro Lys 210 215 220 cag ctg atc cag caa gta ggc aat gaa gcc tat gtt ata ggg ctc tcc 782 Gln Leu Ile Gln Gln Val Gly Asn Glu Ala Tyr Val Ile Gly Leu Ser 225 230 235 tcc ttc cac ata cct tca ata gga gct gca tgt gtt tgt ttc tta gaa 830 Ser Phe His Ile Pro Ser Ile Gly Ala Ala Cys Val Cys Phe Leu Glu 240 245 250 ttg ctt ggc ctt gac agc ctc aag ctc gtt gat atg aaa gtg gcc 878 Leu Leu Gly Leu Asp Ser Leu Lys Leu Arg Val Asp Met Lys Val Ala 255 260 265 aat ata att ttg agc tac aag tgc aga aat gaa gat gct cag tac agc 926 Asn Ile Lyle Tyr Cys Arg Asn Glu Asp Ala Gln Tyr Ser 270 275 280 285 ttt atc aga gag tct gta gcc gaa aaa cta tct aaa cta gct gat ggt 974 Phe Ile Arg Glu Ser Val Ala Glu Lys Leu Ser Lys Leu Ala Asp Gly 290 295 300 gaa aag aca acc aca gaa gaa ttg ctt gtt ctc tta gaa gaa ggt aca 1022 Glu Lys Thr Thr Thr Glu Glu Leu Leu Val Leu Leu Glu Glu Gly Thr 305 310 315 tgg aac agc att cag caa cag gaa ata aag agg gtta tcc aa tct 1070 Trp Asn Ser Ile Gln Gln Gln Glu Ile Lys Arg Leu Ser Ser Glu Ser 320 325 330 agc agc caa tgg gca tta gtg gtg cag ttc tgc agg cta cac aat atg 1118 Ser Ser Gln Trp Ala Leu Val Val Gln Phe Cys Arg Leu His Asn Met 335 340 345 aaa cta agc ata tct tac ctt aga gaa tgt gcc aaa gca aat gat tgg 1166 Lys Leu Ser Ile Ser Tyr Leu Arg Glu Cys Ala Lys Ala Asn Asp Trp 350 355 360 365 ctg cag ttc att at cac agc caa ctc cac aac tac cac cca gca gag 1214 Leu Gln Phe Ile Ile His Ser Gln Leu His Asn Tyr His Pro Ala Glu 370 375 380 gtg aaa tcc ctt atc cag tac ttc agc cca gtc att caa gac cac tta Val Ser Leu Ile Gln Tyr Phe Ser Pro Val Ile Gln Asp His Leu 385 390 395 agg ctg gct ttt gag aac ttg ccc tca gtg ccc acc tcc aaa atg gac 1310 Arg Leu Ala Phe Glu Asn Leu Pro Ser Val Pro Thr Ser Lys Met Asp 400 405 410 agc gat caa gtc tgc aat aag tgc ccc cag gaa ctt caa gga agc aaa 1358 Ser Asp Gln Val Cys Asn Lys Cys Pro Gln Glu Leu Gln Gly Ser Lys 415 420 425 caa gag atg acc gat tta ttt gaa attct g ctc caa tgc tca gag gag 1406 Gln Glu Met Thr Asp Leu Phe Glu Ile Leu Leu Gln Cys Ser Glu Glu 430 435 440 445 cca gac tcc tgg cac tgg ctt ctg gtt gaa gca gtg aaa caa cag gcc 1454 Pro Asp Ser Trp Trp Leu Leu Val Glu Ala Val Lys Gln Gln Ala 450 455 460 cct atc ctc agt gtt ctg gcc tca tgt ctc cag ggt gcc agt gcc att 1502 Pro Ile Leu Ser Val Leu Ala Ser Cys Leu Gln Gly Ala Ser Ala Ile 465 470 475 tct tgt ctc tgt gtt tgg atc atc act tct gtg gag gac aat gtt gca 1550 Ser Cys Leu Cys Val Trp Ile Ile Thr Ser Val Glu Asp Asn Val Ala 480 485 490 act gaa gca atg gga cac att cag gac tca aca gag gac cat acc tgg 1598 Thr Glu Ala Met Gly His Ile Gln Asp Ser Thr Glu Asp His Thr Trp 495 500 505 aac ctt gag gat ctt tca gtc atc tgg aga aca tta tta aca aga caa 1646 Asn Leu Glu Asp Leu Ser Val Ile Trp Arg Thr Leu Leu Thr Arg Gln 510 515 520 525 aag agc aaa act ctc atc aga ggt ttc cag ctt ttc ttt aag gat tcc 1694 Lys Ser Lys Thr Leu Ile Arg Gly Phe Gln Leu Phe Phe Lys Asp Ser 530 535 540 ccg tta cta ggt atg gag atg tat gaa ctg tgt atg ttc ttc agg 1742 Pro Leu Leu Leu Val Met Glu Met Tyr Glu Leu Cys Met Phe Phe Arg 545 550 555 aat tat aaa gaa gct gaa gct aaa ctt ctg gag ttt cag 1 Tyr Lys Glu Ala Glu Ala Lys Leu Leu Glu Phe Gln Lys Ser Leu 560 565 570 gaa acg ctt aac aca gca gcc aca aag gtc cac cct gtc atc cct gcc 1838 Glu Thr Leu Asn Thr Ala Ala Thr Lys Val His Pro Val Ile Pro Ala 575 580 585 atg tgg ctg gag gat cag gtg tgt ttc ctt ttg aag ctt atg cta cag 1886 Met Trp Leu Glu Asp Gln Val Cys Phe Leu Leu Lys Leu Met Leu Gln 590 595 600 605 cag tgt aag acc cag gg gag aag ctt tta cag ctc ttt gtt 1934 Gln Cys Lys Thr Gln Tyr Glu Leu Gly Lys Leu Leu Gln Leu Phe Val 610 615 620 gaa aga gag cat ctc ttc tct gat ggt cca gat gtg aaa aag ctt tgc 1982 Glu Arg Glu Ser Asp Gly Pro Asp Val Lys Lys Leu Cys 625 630 635 atc ctt tgc cag att ttg aag gat aca tcc ata gcc att aat cat aca 2030 Ile Leu Cys Gln Ile Leu Lys Asp Thr Ser Ile Ala Ile Asn His Thr 640 645 650 att att acc agc tac agc att gag aat ctt cag cat gaa tgt aga tct 2078 Ile Ile Thr Ser Tyr Ser Ile Glu Asn Leu Gln His Glu Cys Arg Ser 655 660 665 att ttg gaa aga ctg cag aca gat gga caa ttc gcc agg agg 2126 Ile Leu Glu Arg Leu Gln Thr Asp Gly Gln Phe Ala Leu Ala Arg Arg 670 675 680 685 gta gca gaa tta gct gag tta cct gtg gac aac ttg gtt att aaa gag 2174 Val Ala Glu Leu Ala Glu Pro Asp Asn Leu Val Ile Lys Glu 690 695 700 ata aca cag gaa atg cag acc cta aaa cac att gaa cag tgg tca cta 2222 Ile Thr Gln Glu Met Gln Thr Leu Lys His Ile Glu Gln Trp Ser Leu 705 710 715 715 aaa caa gca aga aga att gac ttc tgg aaa aaa tgc cat gag aat ttt aag 2270 Lys Gln Ala Arg Ile Asp Phe Trp Lys Lys Cys His Glu Asn Phe Lys 720 725 730 aaa aaa aat tca att tca agc aaa gca gct tct tcc ttt ttc tca acc cag 318 Asn Ser Ile Ser Ser Lys Ala Ala Ser Ser Phe Phe Ser Thr Gln 735 740 745 gcc cat gtg gca tgt gag cac cca act gga tgg agc agc atg gag gag 2366 Ala His Val Ala Cys Glu His Pro Thr Gly Trp Ser Ser M et Glu Glu 750 755 760 765 cgc cat ctg ctg ctc acc ttg gca ggg cac tgg ctt gcc cag gag gac 2414 Arg His Leu Leu Leu Thr Leu Ala Gly His Trp Leu Ala Gln Glu Asp 770 775 775 780 gtg gtg ccc ttg atg gag gag ctg gag aag cag atc tgg ctg 2462 Val Val Pro Leu Asp Lys Leu Glu Glu Leu Glu Lys Gln Ile Trp Leu 785 790 795 tgc cgc atc acc cag cac act ctt gga aga aat cag gag gaa aca gag 2510 Cys Arg Ile Gln His Thr Leu Gly Arg Asn Gln Glu Glu Thr Glu 800 805 810 ccc aga ttt tct cga cag atc tca act agt ggt gaa ctt tcc ttt gat 2558 Pro Arg Phe Ser Arg Gln Ile Ser Thr Ser Gly Glu Leu Ser Phe Asp 815 820 825 agt tta gcc aag cac tgg cct cag ggg aag cta gta tgg agg atc tgc 2606 Ser Leu Ala Lys His Trp Pro Gln Gly Lys Leu Val Trp Arg Ile Cys 830 835 840 845 acc cag aga tcc atg ctc tcc tac aaa gtg ctg tgc ttg agg aag 2654 Thr Gln Arg Ser Met Leu Ser Tyr Lys Val Leu Ser Cys Leu Arg Lys 850 855 860 aag cac ccg aca ttc ccc taaggagagt ccacagcact tcaagtctgg 2702 Lys His Pro Thr Phe Pro 865 atagtcag aa gtttgtgaca gtgccctcca gtaatgaagt ggtaactaac ctggaagtgc 2762 tgacaagcaa atgcctccat gggaagaact actgtcgaca ggtcctctgt ctgtatgatc 2822 ttgccaagga gttgggctgt tcctacacag atgttgctgc tcaggatggt gaagccatgc 2882 tccggaaaat cttggcctct cagcagcctg accgatgcaa acgagcccag gccttcatca 2942 gcacacaggg ccttaagcca gatactgtgg ctgaactcgt ggcagaagag gtgacacggg 3002 agctgcttac ttcatcacag ggaacaggac ataagcagat gttcaaccca acagaggaaa 3062 gccagacatt tcttcagctg accactctgt gtcaagaccg cacattggta ggcatgaagt 3122 tgttggataa gatttcctcc gttccccatg gggaactgtc ttgcaccaca gagctcctga 3182 tcctggccca tcattgcttc accctgacgt gccacatgga gggcatcatc cgagtcctac 3242 aggccgccca catgctcaca gataaccacc tggcccccag tgaggagtat gggctggtgg 3302 tacggctcct cactggcatt ggaaggtaca acgagatgac atacatattt gatttgctgc 3362 ataaaaagca ctactttgaa gtgctaatga ggaagaagtt ggatccgagt ggtaccctga 3422 aaacagccct gctggactac atcaaacgct gccgtcctgg agacagtgaa aagcacaata 3482 tgattgccct gtgcttcagc atgtgccggg agattggcga gaaccacgag gcagctgccc 3542 gcatccaact gaa attgatt gagtctcagc cctgggagga cagcctcaag gatgggcacc 3602 agctgaaaca actgctgctg aaggccctga ctctgatgtt ggatgcagca gagagttatg 3662 ccaaggactc ctgtgtgcga caggcccagc actgtcagcg gctcaccaag ttgataactc 3722 tgcagattca ctttctgaac actggccaga acacaatgct catcaacttg ggccgccaca 3782 agctgatgga ctgtattctg gccctacctc ggttctacca ggcttctatt gtggctgagg 3842 cctacgattt tgttccagat tgggctgaaa ttttatacca gcaagtgatt cttaaaggag 3902 actttaatta cttggaagaa tttaagcagc aaaggttatt aaagtccagt atatttgaag 3962 agatttccaa aaaatataaa caacatcagc ctactgacat ggtcatggaa aacctgaaga 4022 aattactcac atattgtgaa gatgtttacc tgtattacaa gttggcatac gaacacaagt 4082 tttatgaaat tgtaaatgtg cttctgaagg accctcagac aggttgctgt ctaaaggaca 4142 tgctagcagg ttagatgatt tcataggtgt ctgttttctt gtactgttag cagattctga 4202 cagatgtgat gagaagaaga atgcattgga gatctttgct aaagttgaac aatcccggta 4262 ctgtaccata tcagtccttt gtgggtagta ggtagcaagt aagaaacttt tcaggaggaa 4322 attcctattt aaaatagatt gattttagat gattgttcat ccacaccatt ttatatagat 4382 actagtatta agatcaaaa g cttcctcttc ctcaggacag cttctacttt agatgatcca 4442 ataatgatta aagaatacct gtacctgcag attccagttt caaagaaatt taattattat 4502 ttacacagtt aaggaacagg tgatacattt tcatttgtta gaaactgatc tttctgtagatta 4562 <210> 43 <211> 4364 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1767) .. (3956) <400> 43 aataatctct gaatagtgat gccacagtta ttctcttttc atattccttt tcctttttgc 60 ttccaggatg taacattgtt ctaatcttta atttgccaga gaatttaagt gatctgaaga 120 aaatacacag tatctgcttc tgtttctctc tgtcattaaa tctggattgc aagaaaaatt 180 atttatccag gtgtcctctt ttggttgttt ccttgattta cataaaaatg atctcctatc 240 cttttccctc ttttccccca aatgaggagg acaatgaaga tctgaagtgc cagctgcagt 300 ttgttaagga agaagccgct ttgatgagaa agaaaatggc caagattgat aaagaaaagg 360 acagatttga acacgagctc cagaagtaca gatcctttta tggggatctg gacagtcctt 420 tgcccaaagg agaagccgga ggccctccca gcactaggga ggccgagctc aagctacggc 480 taaggctggt ggaggaagaa gccaacatcc tgggcaggaa aatcgtcgaa ctggaggtgg 540 agaacagagg cctgaaggcg gaactggacg accttagggg cgatgacttc aacggctcgg 600 ccaacccgct catgagggag cagagcgaat ccctgtcgga gctgcggcag cacctgcagc 660 tggtggaaga cgagacggag ctgctgcgga ggaacgtggc cgacctggag gagcagaaca 720 agcgcatcac ggcggagctc aacaagtaca agtacaagtc cggcggccac gacagcgcgc 780 ggcaccacga caacgccaag accgaggccc tgcaggagga gctgaaggcg gcgcgcctgc 840 agatcaacga g ctcagcggc aaggtcatgc agctgcagta cgagaaccgc gtgcttatgt 900 ccaacatgca gcgctacgac ctggcctcgc acctgggcat ccgcggcagc ccccgcgaca 960 gcgacgccga gagcgacgcg ggcaagaagg agagcgacga cgactcgcgg cctccgcacc 1020 gcaagcgcga agggcccatc ggcggcgaga gcgactcgga ggaggtgcgc aacatccgct 1080 gcctcacgcc cactcgctcc ttctacccgg cgcccgggcc ctggcccaag agcttctccg 1140 atcggcagca gatgaaggac atccgctcgg aggccgagcg cctgggcaag accatcgacc 1200 ggctcatcgc cgacacgagc accatcatca ccgaggcgcg catctacgtg gccaacgggg 1260 acctgttcgg actcatggac gaggaggacg acggcagccg catccgggag cacgagctgc 1320 tctaccgcat caacgctcag atgaaggcct tccgcaagga gctgcagacc ttcatcgacc 1380 gcctcgaggt gcccaagtct gcggacgacc gcggcgccga ggagcccatt tccgtgagtc 1440 agatgttcca gcctatcatt ttacttattc tcattcttgt attattttca tcactttctt 1500 acacaacaat atttaaactt gtcttccttt ttacactgtt ttttgtactg taaatctttc 1560 atcatttacc attcattgta gtattttcag tttgtttatt ttgttcaccc ttcaagacaa 1620 gaagtaaaag aagtataatt tctgtagtaa ccaatgctat aaaaacactg aagactgctt 1680 atttctttaa aaagataca a ctcatcttac caagaccaaa ttcaataaga agcccaaaca 1740 ctaaaatatt tcaggcttta ttttaa agg caa gtg aga ctg ctt caa ata aaa 1793 Arg Gln Val Arg Leu Leu Gln Ile Lys 1 5 caa ctt caa gct tcc aag aga gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag cag Ala Ser Lys Lys Gln Leu Arg Gly Gly Arg Glu Glu Gln 10 15 20 25 aaa cac ttc ttt gct gac act tac act gtt gcc atg gac cta cat aag 1889 Lys His Phe Phe Ala Asp Thr Tyr Thr Val Ala Met Asp Leu His Lys 30 35 40 cag tgg gag aac aca gag act aac tgg cat aag gaa aag atg gaa tta 1937 Gln Trp Glu Asn Thr Glu Thr Asn Trp His Lys Glu Lys Met Glu Leu 45 50 55 ctg gac cag ttt gac aat gaa aga aag gaa tgg gaa agt caa tgg aag 1985 Leu Asp Gln Phe Asp Asn Glu Arg Lys Glu Trp Glu Ser Gln Trp Lys 60 65 70 att atg cag aag aaa ata gaa gag ctt tgc cgg gaa gta aag ctt tgg 2033 Ile Met Gln Lyslus Ilu Glu Leu Cys Arg Glu Val Lys Leu Trp 75 80 85 agg aaa atc aat atc aat gaa agt gct aag atc att gat ctt tac cat 2081 Arg Lys Ile Asn Ile Asn Glu Ser Ala Lys Ile Ile Asp Leu T yr His 90 95 100 105 gag aag acc att cca gag aaa gtg ata gaa tct tcc cca aat tac ccc 2129 Glu Lys Thr Ile Pro Glu Lys Val Ile Glu Ser Ser Pro Asn Tyr Pro 110 115 120 gat tta gga caa agt gaa ttt ata agg acg aat cac aaa gat ggt ctg 2177 Asp Leu Gly Gln Ser Glu Phe Ile Arg Thr Asn His Lys Asp Gly Leu 125 130 135 aga aaa gaa aat aaa aga gag cag agc tta gtc agt gga gga aat caa 2225 Arg Lys Glu Asn Lys Arg Glu Gln Ser Leu Val Ser Gly Gly Asn Gln 140 145 150 atg tgt aag gaa caa aaa gca aca aaa aaa tca aaa gta ggg ttt ttg 2273 Met Cys Lys Glu Gln Lys Ala Thr Lys Lys Ser Lys Val Gly Phe Leu 155 160 165 gat cct ttg gct aca gac aac caa aag gaa tgt gag gcc tgg cct gac 2321 Asp Pro Leu Ala Thr Asp Asn Gln Lys Glu Cys Glu Ala Trp Pro Asp 170 175 180 185 ctg agg act tct gag gaa gac agc aag aggc tgt gcc ctc agt 2369 Leu Arg Thr Ser Glu Glu Asp Ser Lys Ser Cys Ser Gly Ala Leu Ser 190 195 200 aca gct ctt gaa gaa ctt gcg aag gtg agt gaa gaa tta tgc agc ttt 2417 Thr Ala Leu Glu Glu Leu Ala Lys Val Ser Glu Glu Leu Cys Ser Phe 205 210 215 caa gag gaa att cga aag cgg tct aac cat aga agg atg aag tca gat 2465 Gln Glu Glu Glu Ile Arg Lys Arg Ser Asn His Arg Arg Met Lys Ser Asp 220 225 230 tct ttt ctc cag gaa atg cca aat gta act aat ata cct cat ggg gac 2513 Ser Phe Leu Gln Glu Met Pro Asn Val Thr Asn Ile Pro His Gly Asp 235 240 245 ccc atg atc aac aat gac cag tgc att ctt cca atc agt tta gaa aaa 2561 Pro Met Ile Asn Asn Asp Gln Cys Ile Leu Pro Ile Ser Leu Glu Lys 250 255 260 265 gaa aaa cag aaa aac agg aag aat ctg agc tgt acc aat gtg ctc cag 2609 Glu Lys Gln Lys Asn Arg Lys Asn Leu Ser Cys Thr Asn Val Leu Gln 270 275 280 agc aat tct acg aaa aaa tgt gga att gat aca atc gat tta aaa aga 2657 Ser Asn Ser Thr Lys Lys Cys Gly Ile Asp Thr Ile Asp Leu Lys Arg 285 290 295 aat gaa act cca cca gtt cct cctca aga agc acc tct cga aat ttt 2705 Asn Glu Thr Pro Pro Val Pro Pro Pro Arg Ser Thr Ser Arg Asn Phe 300 305 310 ccc agc tcg gat tct gaa caa gcc tat gaa aga tgg aag gaa agg tta 2753 Pro Ser Ser Asp S er Glu Gln Ala Tyr Glu Arg Trp Lys Glu Arg Leu 315 320 325 gac cac aac agc tgg gtg ccc cat gag ggt cga agt aaa agg aat tac 2801 Asp His Asn Ser Trp Val Pro His Glu Gly Arg Ser Lys Arg Asn Tyr 330 335 340 345 aac cct cac ttc cct ttg aga caa caa gag atg tct atg ttg tat cca 2849 Asn Pro His Phe Pro Leu Arg Gln Gln Glu Met Ser Met Leu Tyr Pro 350 355 360 aat gaa ggg aaa act tcg aaa gat ggt atc atc ttt tcc tct ttg gta 2897 Asn Glu Gly Lys Thr Ser Lys Asp Gly Ile Ile Phe Ser Ser Leu Val 365 370 375 cca gaa gtc aaa ata gat agc aag cct cca agt aat gaa gat gtt gga 2945 Pro Glu Val Lys Ile Asp Ser Lys Pro Pro Ser Asn Glu Asp Val Gly 380 385 390 ctt agc atg tgg tca tgt gac att ggg ata ggt gca aaa agg agc ccc 2993 Leu Ser Met Trp Ser Cys Asp Ile Gly Ile Gly Ala Lys Arg Ser Pro 395 400 405 tct act tcg tgg ttt cag aaa acc tgc tct acc ccc agt aat cca aaa 3041 Ser Thr Ser Trp Phe Gln Lys Thr Cys Ser Thr Pro Ser Asn Pro Lys 410 415 420 425 tat gaa atg gtg atc cca gat cac cct gct aaa tct cat cct gat ct t 3089 Tyr Glu Met Val Ile Pro Asp His Pro Ala Lys Ser His Pro Asp Leu 430 435 440 cat gta agt aat gac tgt agc tcc tca gta gca gag agc agt agc cca 3137 His Val Ser Asn Asp Cys Ser Ser Ser Val Ala Glu Ser Ser Ser Pro 445 450 455 ctt aga aat ttc agt tgt ggc ttt gaa agg act aca agg aat gag aag 3185 Leu Arg Asn Phe Ser Cys Gly Phe Glu Arg Thr Thr Arg Asn Glu Lys 460 465 470 ctg gca gca aag act gat gaa ttt aac aga act gta ttt aga aca gat 3233 Leu Ala Ala Lys Thr Asp Glu Phe Asn Arg Thr Val Phe Arg Thr Asp 475 480 485 aga aat tgt cag gca ata cag caa aat cac agc tgc tca aaa tca tcg 3281 Arg Asn Cys Gln Ala Ile Gln Gln Asn His Ser Cys Ser Lys Ser Ser 490 495 500 505 gag gat ctc aag ccc tgt gat acc tca tct act cac aca ggt agc ata 3329 Glu Asp Leu Lys Pro Cys Asp Thr Ser Ser Thr His Thr Gly Ser Ile 510 515 520 tca caa agt aac gat gtg tcc ggt att tgg aaa acc aat gcc cac atg 3377 Ser Gln Ser Asn Asp Val Ser Gly Ile Trp Lys Thr Asn Ala His Met 525 530 535 535 cct gtg ccc atg gaa aat gtg cct gat aat ccc acc aag aaa tcc aca 3425 Pro Val Pro Met Glu Asn Val Pro Asp Asn Pro Thr Lys Lys Ser Thr 540 545 550 aca ggc cta gta aga caa atg cag gga cac cta agt cct cgc agt tat 3473 Thr Gly Leu Val Arg Gln Met Gln Gly His Leu Ser Pro Arg Ser Tyr 555 560 565 cga aat atg ctc cac gag cat gac tgg aga ccg agt aat ttg tct ggc 3521 Arg Asn Met Leu His Glu His Asp Trp Arg Pro Ser Asn Leu Ser Gly 570 575 575 580 585 cgt ccg agg tca gct gat ccc agg tca aat tat ggt gtt gtg gaa aag 3569 Arg Pro Arg Ser Ala Asp Pro Arg Ser Asn Tyr Gly Val Val Glu Lys 590 595 600 ctg ctg aaa acc tat gag aca gca aca gag tct gca ttg caa aat tct 3617 Leu Leu Lys Thr Tyr Glu Thr Ala Thr Glu Ser Ala Leu Gln Asn Ser 605 610 615 aag tgc ttc cag gat aat tgg acc aaa tgt aat tct gat gtc agt ggt 3665 Lys Cys Phe Gln Asp Asn Trp Thr Lys Cys Asn Ser Asp Val Ser Gly 620 625 630 ggt gcc aca tta agt cag cat tta gaa atg ctc caa atg gaa caa cag 3713 Gly Ala Thr Leu Ser Gln His Leu Glu Met Leu Gln Met Glu Gln Gln 635 640 645 ttt cag caa aag aca gct gtg tgg ggg gga cag gaa gtg aag caa gga 3761 Phe Gln Gln Lys Thr Ala Val Trp Gly Gly Gln Glu Val Lys Gln Gly 650 655 660 665 ata gat ccg aaa aag ata aca gag gaa tcc atg tca gtg aac gcctca 3cc Pro Lys Lys Ile Thr Glu Glu Ser Met Ser Val Asn Ala Ser 670 675 680 cat gga aaa gga ttt tcc cga cct gct aga cca gca aat cgt cgt ctc 3857 His Gly Lys Gly Phe Ser Arg Pro Ala Arg Pro Ala Asn Arg Arg Leu 685 690 695 ccc tcc aga tgg gca tcc aga tct cca tct gca ccc cct gcc ttg cgg 3905 Pro Ser Arg Trp Ala Ser Arg Ser Pro Ser Ala Pro Pro Ala Leu Arg 700 705 710 aga act acc cac aac tat acc att tct ctg cga tcc gaa gca ttg atg 3953 Arg Thr Thr His Asn Tyr Thr Ile Ser Leu Arg Ser Glu Ala Leu Met 715 720 725 gtt taagtctttg gcctggattg ctatattaca gaagttctag tcccacttgt 4006 Val 730 caaacagagc attctgagtg tttacaggcg gacctgttct cttccgacaa gcaatttgaa 4066 tcttaacttt ccatcagtct tcagtgtttt taatctaagg aataattatc ttcctgcatt 4126 ttgatttctt agatcagaat ttttttaatg ccatcctcat tagttttcca atacaatata 4186 agttgaaac a atgtacaata ttgtatattc tttgttgcaa gtggcagaaa gtaaggttat 4246 gtgcatggcc atgtgtttgt aggtgcatgt gttgaaatag gaagtatcct agtatgtatt 4306 tagatatgaa aaacttatgt gctagtgttg actttgaaat tataacatgt atacctat <210> 44 <211> 3883 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1215) <400> 44 ctc aga aac agt ggt tta tcc tac tgc agc aag ttc att aaa agg aac 48 Leu Arg Asn Ser Gly Leu Ser Tyr Cys Ser Lys Phe Ile Lys Arg Asn 1 5 10 15 act aag gag aat aag gat tgt gag atg ccc act tta gag cca gga aat 96 Thr Lys Glu Asn Lys Asp Cys Glu Met Pro Thr Leu Glu Pro Gly Asn 20 25 30 gtc att tca att ctt att tct tcg gag ttt tta aaa atg gat tca cta 144 Val Ile Ser Ile Leu Ile Ser Ser Glu Phe Leu Lys Met Asp Ser Leu 35 40 45 gtt gaa cag tgt att cag tat tgc cac aaa aat atg aat gcc ata gta 192 Val Glu Gln Cys Ile Gln Tyr Cys His Lys Asn Met Asn Ala Ile Val 50 55 60 gct acc cca tgc aac atg aac tgt att aat gca aat ctt ctc aca cgt 240 Ala Thr Pro Cys Asn Met Asn Cys Ile Asn Ala Asn Leu Leu Thr Arg 65 70 75 80 ata gct gat ctg ttc tca cac aat gaa gtt gat gat tta aag gac aaa 288 Ile Ala Asp Leu Phe Ser His Asn Glu Val Asp Asp Leu Lys Asp Lys 85 90 95 aaa gat aaa ttt aaa agc aaa ctt ttt tgt aag aag att gaa aga ctg 336 Lys Asp Lys Phe Lys Ser Lys Leu Phe Cys Lys Lys Ile Glu Arg Leu 100 105 11 0 ttt gat cct gag tac ttg aat cca gat tct cgg agt aat gca gca aca 384 Phe Asp Pro Glu Tyr Leu Asn Pro Asp Ser Arg Ser Asn Ala Ala Thr 115 120 125 ttg tat aga tgc tgt ttg tgt aag aaa ctt tta aca aaa gaa aca gaa 432 Leu Tyr Arg Cys Cys Leu Cys Lys Lys Leu Leu Thr Lys Glu Thr Glu 130 135 140 aga aga att cct tgc att cct gga aaa atc aat gtg gat cga cgt gga 480 Arg Arg Ile Pro Cys Ile Pro Gly Lys Asn Val Asp Arg Arg Gly 145 150 155 160 aat att gtc tat att cac ata aga gat aag aca tgg gat gtt cat gag 528 Asn Ile Val Tyr Ile His Ile Arg Asp Lys Thr Trp Asp Val His Glu 165 170 175 tat ttg aat agt ctt ttc gaa gaa tta aaa tct tgg aga gat gta tac 576 Tyr Leu Asn Ser Leu Phe Glu Glu Leu Lys Ser Trp Arg Asp Val Tyr 180 185 190 tgg cga ttg tgg gga aca atc aat tgg ctg act tgt tca aga tgt tat 624 Arg Leu Trp Gly Thr Ile Asn Trp Leu Thr Cys Ser Arg Cys Tyr 195 200 205 cag gcc ttt ctc tgt att gaa ttt tca cat tgt caa tac cac tca gaa 672 Gln Ala Phe Leu Cys Ile Glu Phe Ser His Cys Gln Tyr His Ser Gl u 210 215 220 aca gtg gtt tat cct act gca gca agt tca ttg aat act gtt ggc act 720 Thr Val Val Tyr Pro Thr Ala Ala Ser Ser Leu Asn Thr Val Gly Thr 225 230 235 240 gga att tat ccc tgc tgt aac caa aag gtt ctt cgg ttt gat cct act 768 Gly Ile Tyr Pro Cys Cys Asn Gln Lys Val Leu Arg Phe Asp Pro Thr 245 250 255 cag ctt aca aag ggc tgt aaa gtg agg gac cac atg gtt aca ctt cgt 816 Gln Leu Thr Lys Gly Cys Lys Val Arg Asp His Met Val Thr Leu Arg 260 265 270 gat caa ggt gaa ggc gga gat ttg ccg tcc tgt ccc act gct aga atg 864 Asp Gln Gly Glu Gly Gly Asp Leu Pro Ser Cys Pro Thr Ala Arg Met 275 280 285 ttg gac gat ttg cac aag tac aga gat gtc att gtt gtg cct ttt tca 912 Leu Asp Asp Leu His Lys Tyr Arg Asp Val Ile Val Val Pro Phe Ser 290 295 300 aaa gat aca gtt agt gat gtt ggg gtt ggc ctc tgt gat ag ggt 960 Lys Asp Thr Val Ser Asp Val Gly Val Gly Leu Cys Asp Glu Lys Gly 305 310 315 320 ata gaa tgt gat gtt tta ctg gag cca aat aca cca tgg ggt ccc aaa 1008 Ile Glu Cys Asp Val Leu Leu Glu Pro Asn Thr P ro Trp Gly Pro Lys 325 330 335 act ggg gag ctc aat gct ttc ttg tca ttg aaa aac tgg act cta caa 1056 Thr Gly Glu Leu Asn Ala Phe Leu Ser Leu Lys Asn Trp Thr Leu Gln 340 345 350 ctg aaa caa cag tcactg ttt tca gaa gaa gaa tat acc act gga 1104 Leu Lys Gln Gln Ser Leu Phe Ser Glu Glu Glu Glu Tyr Thr Thr Gly 355 360 365 tct gag gtc act gaa gat gaa gtt gga gat gaa gaa gaa gta tcc aag 1152 Ser Glu Thr Glu Asp Glu Val Gly Asp Glu Glu Glu Val Ser Lys 370 375 380 aaa caa act act tgg gag gcc gag gca cga gaa tcg ctt gaa ccg ttg 1200 Lys Gln Thr Thr Trp Glu Ala Glu Ala Arg Glu Ser Leu Glu Pro Leu 385 390 395 400 aag cag aga ttg cag tgagccgaga tcatgccact gcactccagc atgggtgaca 1255 Lys Gln Arg Leu Gln 405 gaacaagact ctgtctcaaa aaaaaagaaa aagaaaatga acccctgtaa agcaatttca 1315 gcttatgaac ccctgtaaag caatttcagc tttgcttcat gggaaaaagg agaagccaaa 1375 gaagttcact agacaaccaa aaaagcaggt atcttcaccc tgtgcccaga ggaaagaaaa 1435 ggcattggag aagtcagctt ctagagatgt gtctcctttc gttatgagta tgcagaagaa 1495 taagtggg at gccacaagat ccttgagatt caaccaggat gcacaaagag aagacgatca 1555 acggcgaatg actgaaatta cagggcacct aataaaaatg agattggggg atctggaccg 1615 agtcaagtca aaggaagcaa aagaatttgc aggaggtatt tattccaggc tggaagcaca 1675 aatcaaggcc tcagtgccag ttagtgcacg ccaaagcagc tcagagaaaa acacaaggtc 1735 taaaagtcgt tttggtcaag ggcgtcctgc ataaagtacc ttaaaatata agtaaaaaga 1795 gagaaggcac tcttctggac atctgaaatt gctcacttct tgaagatctt cagaacaatg 1855 acttccaact gttttatgtt attattattt taatccacat aaatcataat tctaaaagaa 1915 atacatagtt aggttttatg aaaatctaat tgtaaatatg aaacttttta aatctgattt 1975 tcttctaata tcattctagg ctatgtagaa agcaattatt tacaaatttg catagttgag 2035 actcccagtg ttttccttta tttatttgaa aaagaaaggc ctaaactgtc aggtagccaa 2095 gtttttttaa gaccttaaaa gttaggggaa cacaactggt agtgttacca tgcatggcac 2155 tgattgtagt atgtctttgg agctgtaaat cttgagatag cattgagaac tgcaggttgt 2215 gtgacgaaat tcccaatgat gctaatttta agtctgcatg aatattaagg agtgacaggt 2275 ctcaagactg cattaaatga agtttcaggg taaggtattt cagtactgtg ttgggcagaa 2335 gggttaattt tt ttcagcat tatatcgtgg aaagtacaat gttaatccaa cttttttttc 2395 tttcagtttt taatgcttat ctattgatca tctgagctgg aattactgat tattactctg 2455 tcctctgtga aactagtggc attctgaatt tggtaaaata accattgata gttttaggat 2515 agtaaatcat ttctgttata tgagacaccc actgtacagt tctcagggct ctaaaaccca 2575 accatatttc tgtaaccatt caaataactc cttgaaacag ttatacttgc tagttcggtc 2635 taaaattttc caaatacatt agataggtga aaatttgcat atattcaaga aaaatcaaaa 2695 taaaattcta ttttataaat catgtttaaa tttttctagc caggcagaaa gagtgctcag 2755 ggaaaatttg ttccaaacta taaccatata ataaattatg tgtttgtaaa ttatatgtag 2815 gtctctgaaa aactttaaga tgcactgttt ctattttttt aagtcttaat ttgccttata 2875 actgacattt cttcaaatta ttcagagaac agactttaat aatgtgtgac aaaagagcaa 2935 tttccattga aatattgaag tgttacactc agtttacacg tacagaaatc attcttttta 2995 gtgagtcttt tagttgataa atgaagctag atgttatttg ataactggct ttgccaaggt 3055 ttttgaactg ctgtttagaa attttgttcc catttatatt tgtttcaatt gtttgatact 3115 gtggaaatag acttttattt tcgaaagaaa atgtcttgta gtacatatta tatgtaagta 3175 ctctgttaaa taccaga gtt ttttttgtag tttactgtgt tttctgatta aaggatttgg 3235 atttgtacat gtaaacagtg ctgtaatggt cacgactaga taaggaaaaa atatatatgc 3295 tcttttgatt tttaactgat ggtaaaaagg caaactgctt ctcccctggg aggcctatac 3355 cactgaatta atttttacaa accagagttt atcagaattt gattctcttc agaatgcttt 3415 tggccaggtg tagtggctca cgccagtaat cccagcactt tgggaggccg aggcgggcag 3475 atcacctgag gtcaggagtt tgagaccagc ctggccaacg tggtgaaacc ctatctctac 3535 taaaaataca aaaagattag ccaggcatgg tggcatacac ctgtagtccc agctactcgg 3595 gaggctgagg cacaagaatt gtttgaaccc gggtggcaga ggttgcagtg agctgagatc 3655 atgccactgc gctcctagcc tgggtgacag agcaagactc catctcaatt taaaacaaaa 3715 aaagaatgtg tttttaattt tgttaatgtt tgtctgttat acatagcact ggtaccgcaa 3775 acattttact taaactctta atagcatttc tttcgccaga tactttaata tttcacctta 3835 cattaatcct ggattcacat ttctttaatt gaaataaatg ttaatgac 3883 <210> 45 <211> 4195 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (31) .. (3873) <400> 45 tgcaactaga gtttcttcaa tattttctag gtg tgt ata gga caa att cta cga 54 Val Cys Ile Gly Gln Ile Leu Arg 1 5 ata ata caa cta ctt gga acc aca cca cga cta aga gct gtc act ttg 102 Ile Ile Gln Leu Thr Pro Arg Leu Arg Ala Val Thr Leu 10 15 20 cgc ttg ctg aca tct ttg tgg gaa aag cag gac cga gtc tat cct gaa 150 Arg Leu Leu Thr Ser Leu Trp Glu Lys Gln Asp Arg Val Tyr Pro Glu 25 30 35 40 ctg cag cgt ttc atg gct gtg tct gat gta cct tct ctt tcg gtg ggc 198 Leu Gln Arg Phe Met Ala Val Ser Asp Val Pro Ser Leu Ser Val Gly 45 50 55 aag gaa gtc caa tgg gag aaa ctg att gca aaa gca gca atc atc aga 246 Lys Glu Val Gln Trp Glu Lys Leu Ile Ala Lys Ala Ala Ser Ile Arg 60 65 70 gat ata tgt aag cag agg cca tat caa cat ggt gca gat atg ttg gca 294 Asp Ile Cys Lys Gln Arg Pro Tyr Gln His Gly Ala Asp Met Leu Ala 75 80 85 gct att tct caa gtg ttg aat gaa tgc acc aag cct gat caa gct act 342 Ala Ile Ser Gln Val Leu Asn Glu Cys Thr Lys Pro Asp Gln Ala Thr 90 95 100 cca gca gcc ttg gta tta cag ggt ctt c at gca ctc tgt caa gct gag 390 Pro Ala Ala Leu Val Leu Gln Gly Leu His Ala Leu Cys Gln Ala Glu 105 110 115 120 gtt gtt tgc att cgc tcc act tgg aat gct ctc tct cca aag ctg agt 438 Val Val Cys Ile Arg Ser Thr Trp Asn Ala Leu Ser Pro Lys Leu Ser 125 130 135 tgt gac aca aga cct ctc att ctg aag aca ctg agt gaa cta ttt tct 486 Cys Asp Thr Arg Pro Leu Ile Leu Lys Thr Leu Ser Glu Leu Phe Ser 140 145 150 cta gtt cct tcc tta acg gtc aat aca act gaa tat gag aat ttt aaa 534 Leu Val Pro Ser Leu Thr Val Asn Thr Thr Glu Tyr Glu Asn Phe Lys 155 160 165 gtt caa gtc ctc agc ttc ctc tgg act cat act caa aac aag gac cca 582 Val Gln Val Leu Ser Phe Leu Trp Thr His Thr Gln Asn Lys Asp Pro 170 175 180 att gta gca aat gct gca tat aga tcc ctg gcc aac ttt agt gca gga 630 Ile Val Ala Asn Ala Ala Tyr Arg Ser Leu Ala Asn Phe Ser Ala Gly 185 190 195 200 gaa cac acc att ctt cat ctg cct gaa aag ata aga cca gaa att ccc 678 Glu His Thr Ile Leu His Leu Pro Glu Lys Ile Arg Pro Glu Ile Pro 205 210 215 att cct gaa gag ttagat gac gat gaa gat gtt gag gat gtg gat ctt 726 Ile Pro Glu Glu Leu Asp Asp Asp Glu Asp Val Glu Asp Val Asp Leu 220 225 230 tca gtt cct ggc tct tgc tat ctc aaa ctg ttg tca ctc act ccc cct Pro Gly Ser Cys Tyr Leu Lys Leu Leu Ser Leu Thr Pro Pro 235 240 245 ttg gtt tta cca gct ttg gag gaa ttt ttt aca tca ctt gtg aag caa 822 Leu Val Leu Pro Ala Leu Glu Glu Phe Phe Thr Ser Leu Val Lys Gln 250 255 260 gaa atg gtg aat atg cct cgt ggg ata tat cac tct gca tta aaa gga 870 Glu Met Val Asn Met Pro Arg Gly Ile Tyr His Ser Ala Leu Lys Gly 265 270 275 280 ggt gcc cgc tca gac caa gga aag act gta gca gga atc ccc aat ttt 918 Gly Ala Arg Ser Asp Gln Gly Lys Thr Val Ala Gly Ile Pro Asn Phe 285 290 295 ata ttg aaa atg tat gaa aca aac aag caa cca gga ctg aaa cct ggc 966 Ile Leu Lys Met Gyr Asn Lys Gln Pro Gly Leu Lys Pro Gly 300 305 310 ctt gca ggt ggt atg tta ttt tgc tat gat gtt tcc atg tat cag agt 1014 Leu Ala Gly Gly Met Leu Phe Cys Tyr Asp Val Ser Met Tyr Gln Ser 315 320 325 aaa gat gga aaa cca ttg aac aga ctg atg gcc agc aga ggg cga agt 1062 Lys Asp Gly Lys Pro Leu Asn Arg Leu Met Ala Ser Arg Gly Arg Ser 330 335 340 ttc aag cag act tca ctt gct ctt gta cat gag gtt cat atc cag ctt 1110 Phe Lys Gln Thr Ser Leu Ala Leu Val His Glu Val His Ile Gln Leu 345 350 355 360 tca gag tgg cac cgt gca att ttt ctt cca cag gcc tgg ctt gca tac 1158 Ser Glu Trp His Arg Ala Ile Phe Leu Pro Gln Ala Trp Leu Ala Tyr 365 370 375 atg aat cga gct tat cat gcc att tta cag gga aga cta gga gag ctg 1206 Met Asn Arg Ala Tyr His Ala Ile Leu Gln Gly Arg Leu Gly Glu Leu 380 385 390 390 gag ttg cag tta cat g aaa gaa gaa cct gag gag gtg cag tac 1254 Glu Leu Gln Leu Lys His Gly Lys Glu Glu Glu Pro Glu Glu Val Gln Tyr 395 400 405 aaa aaa agc aca gcc tgg ctc tgg gtt aga gac atg ctg act gat gag 1302 Lys Lys Ala Trp Leu Trp Val Arg Asp Met Leu Thr Asp Glu 410 415 420 atc acc aag gca gct gca aag gag agt ccg gta gtg aaa ggc aat gcg 1350 Ile Thr Lys Ala Ala Ala Lys Glu Ser Pro Val Val Lys Gly Asn Ala 425 430 435 440 ctg tta gct cta agc agc ctt gct gtc gtc gta tct aga cat gaa gcc 1398 Leu Leu Ala Leu Ser Ser Leu Ala Val Val Val Ser Arg His Glu Ala 445 450 455 agc ctc tcc tca gac tct gacggg ct gag gtt caa cct aat ttc 1446 Ser Leu Ser Ser Asp Ser Asp Gly Leu Leu Glu Val Gln Pro Asn Phe 460 465 470 ctt tca atg aaa gag tgg gtt tcc atg gta ctt gat aca ctc ttg gtc 1494 Leu Ser Met Lys Glu Trp Val Ser Met Val Leu Asp Thr Leu Leu Val 475 480 485 att gtg gat agc cat tac caa ccc aga ggg caa ctt ctc tcc tgg ttt 1542 Ile Val Asp Ser His Tyr Gln Pro Arg Gly Gln Leu Leu Ser Trp Phe 490 495 500 tat tat aag tcc tat tct ggt gaa aac aca gct agt gcc att gcc cgt 1590 Tyr Tyr Lys Ser Tyr Ser Gly Glu Asn Thr Ala Ser Ala Ile Ala Arg 505 510 515 515 tct gct gcc gcc acg gct ttg tct ctc ctt gtc cca gtt ttc atc 1638 Ser Ala Ala Ala Thr Ala Leu Ser Leu Leu Val Pro Val Phe Ile Ile 525 530 535 tct tgc aaa gag aag gtt gag gaa atc ctg aac atg ctg act gcc agg 1686 Ser Cys Lys Glu Lys Val Glu Glu Ile Leu Asn Met Leu Thr Ala Arg 540 545 550 tta cct ggg aaa cca agt gct gat gag tct caa gcc gtg caa atc cac 1734 Leu Pro Gly Lys Pro Ser Ala Asp Glu Ser Gln Ala Val Gln Ile His 555 560 565 atg ggc ctt gct tta ggg atg ttt ctc tct cgc ttg tgt gaa gag aaa 1782 Met Gly Leu Ala Leu Gly Met Phe Leu Ser Arg Leu Cys Glu Glu Lys 570 575 580 ctc agt gat ata tct ggc caa gag atg aac ctt ctt tgg agag agag Asp Ile Ser Gly Gln Glu Met Asn Leu Leu Leu Met Lys Ser 585 590 595 600 ttg gat gcc ctg gaa aat tgc tgc ttt gac act agt ctt gaa tac aac 1878 Leu Asp Ala Leu Glu Asn Cys Cys Phe Asp Thryr Le Glu Asn 605 610 615 acg ggc tgt ata ttg gga gtt gga ctt gtt ctg tcc ctc atg agc cac 1926 Thr Gly Cys Ile Leu Gly Val Gly Leu Val Leu Ser Leu Met Ser His 620 625 630 agc agc caa atg cag ccc cgc gtt gca gca ttg ctc cgg aag 1974 Ser Ser Gln Met Gln Ser Arg Val His Val Ala Ala Leu Leu Arg Lys 635 640 645 ctg tct gcg cac gta gat gac agc ggg agc cag agc aga acg ttt cag 2022 Leu Ser Ala His Val A sp Asp Ser Gly Ser Gln Ser Arg Thr Phe Gln 650 655 660 gag gtc ctt gcc tac aca ctt agc tgt gta tgt aca tca gcg ttc agt 2070 Glu Val Leu Ala Tyr Thr Leu Ser Cys Val Cys Thr Ser Ala Phe Ser 665 670 670 675 680 gct gga att att gag gct aca gag gct gag gat gtt atg aac aag ctt 2118 Ala Gly Ile Ile Glu Ala Thr Glu Ala Glu Asp Val Met Asn Lys Leu 685 690 695 cga ctg tta gtg gag aat agc cag tact gca tcagt gcc ctg gct 2166 Arg Leu Leu Val Glu Asn Ser Gln Gln Thr Ser Gly Phe Ala Leu Ala 700 705 710 tta gga aac ata gtt cat ggg ttg tct gtg tgt gga cat gga aaa gct 2214 Leu Gly Asn Ile Val His Gly Leu Ser Val Cys Gly His Gly Lys Ala 715 720 725 gaa gac ttg ggc agc aaa cta ctc cct gcc tgg atc aga att gtt cta 2262 Glu Asp Leu Gly Ser Lys Leu Leu Pro Ala Trp Ile Arg Ile Val Leu 730 735 740 aca cag ggc act aca atg ctt tgt ctg gca gct ctt cat ggc atg 2310 Thr Glu Gly Thr Pro Thr Met Leu Cys Leu Ala Ala Leu His Gly Met 745 750 755 760 gtg gcc ttg gta ggc tct gaa ggg gat gta atg cag ctg aaa tcaga 8 Val Ala Leu Val Gly Ser Glu Gly Asp Val Met Gln Leu Lys Ser Glu 765 770 775 gcc atc cag acc tct cat ttt caa ggc aga ctt aat gaa gtc att aga 2406 Ala Ile Gln Thr Ser His Phe Gln Gly Arg Leu Asn Glu Val Ile Arg 780 785 790 acc tta act cag gtc att agt gtc tct ggg gtg att ggt ctc cag tca 2454 Thr Leu Thr Gln Val Ile Ser Val Ser Gly Val Ile Gly Leu Gln Ser 795 800 805 aat gca gtc tgg ctt ctt gga cat ctt cat cta tct act cta tcc tca 2502 Asn Ala Val Trp Leu Leu Gly His Leu His Leu Ser Thr Leu Ser Ser 810 815 820 agt caa agt aga gcc tct gtt cct act gac tat agc tac ttg cct gaa 2550 Ser Gln Ser Arg Ala Ser Val Pro Thr Asp Tyr Ser Tyr Leu Pro Glu 825 830 835 840 agc agt ttt att gga gca gct att ggc ttc ttc att aca gga gga aaa 2598 Ser Ser Phe Ile Gly Ala Ala Ile Gly Phe Phe Ile Thr Gly Gly Lys 845 850 855 aaa ggt cct gaa tct gtg cct cct tcc ctt ctt aaa gta gtg atg aaa 2646 Lys Gly Pro Glu Ser Val Pro Pro Ser Leu Leu Lys Val Val Met Lys 860 865 870 ccc ata gca act gtt gga gaa agc tac caa tat cct cct gtg aac tgg 2694 Pro Ile Ala Thr Val Gly Glu Ser Tyr Gln Tyr Pro Pro Asn Trp 875 880 885 gct gca ctt ctc tct cca ctt atg agg cta aat ttt ggt gaa gag atc 2742 Ala Ala Leu Leu Ser Pro Leu Met Arg Leu Asn Phe Gly Glu Glu Ile 890 895 900 cag caa ctg tgc ctt gaa att atg gtg acc cag gca cag tca tcc cag 2790 Gln Gln Leu Cys Leu Glu Ile Met Val Thr Gln Ala Gln Ser Ser Gln 905 910 910 915 920 aat gca g gca cta ttg ggc ttg tgg gtg aca cca cca ctg atc cac 2838 Asn Ala Ala Ala Leu Leu Gly Leu Trp Val Thr Pro Pro Leu Ile His 925 930 935 agt ctg agt ctg aat acc aag aga tat ctc ctg ata tg gca Ser Leu Ser Leu Asn Thr Lys Arg Tyr Leu Leu Ile Ser Ala Pro Leu 940 945 950 tgg ata aaa cac atc tct gat gaa cag atc ctg ggt ttt gtt gaa aat 2934 Trp Ile Lys His Ile Ser Asp Glu Gln Ile Leu Gly Phe Val Glu Asn 955 960 965 tta atg gtg gca gtt ttt aaa gca gct tcc cca ctt gga agt cct gag 2982 Leu Met Val Ala Val Phe Lys Ala Ala Ser Pro Leu Gly Ser Pro Glu 970 975 980 cta tgc cca agt gct tta cac ggt ctg agc cag gcc atg aaa ctg ccc 3030 Leu Cys Pro Ser Ala Leu His Gly Leu Ser Gln Ala Met Lys Leu Pro 985 990 995 1000 agc cct gcc cac cac ctc tgg agt ctg ctc tct gaa gct act ggg aaa 3078 Pro A His His Leu Trp Ser Leu Leu Ser Glu Ala Thr Gly Lys 1005 1010 1015 att ttt gac ctc ctg cca aat aag att cgg aga aag gat cta gag ctg 3126 Ile Phe Asp Leu Leu Pro Asn Lys Ile Arg Arg Lys Asp Leu Glu Leu10 1025 1030 tat atc agc ata gca aaa tgc ctc tta gaa atg aca gat gat gat gcc 3174 Tyr Ile Ser Ile Ala Lys Cys Leu Leu Glu Met Thr Asp Asp Asp Ala 1035 1040 1045 aat cgg atc gcc cag gtt act aag agac ac aaa gct gcc ttt 3222 Asn Arg Ile Ala Gln Val Thr Lys Ser Asn Ile Glu Lys Ala Ala Phe 1050 1055 1060 gtc aaa ctg tac tta gtc tct caa gga cga ttc ccc ttg gtg aac ctg 3270 Val Lys Leu Tyr Leu Val Ser Arg Phe Pro Leu Val Asn Leu 1065 1070 1075 1080 acc gat atg ctg agc gtt gct gtg cag cac cgt gag aaa gag gtg ttg 3318 Thr Asp Met Leu Ser Val Ala Val Gln His Arg Glu Lys Glu Val Leu 1085 1090 1095 gcc tgg atg att ctg cac agc tta tac cag gca cgg att gtg agc cat 3366 Ala Trp Met Ile Leu His Ser Leu Tyr Gln Ala Arg Ile Val Ser His 1100 1105 1110 gcc aat acg ggc gtt ttg aag gg atgag ctc ttg gaa ctg atg 3414 Ala Asn Thr Gly Val Leu Lys Arg Met Glu Trp Leu Leu Glu Leu Met 1115 1120 1125 ggt tat att aga aat gtt gct tac cag tca aca tcc ttt cac aat acg 3462 Gly Tyr Ila Arg Asn Val Gln Ser Thr Ser Phe His Asn Thr 1130 1135 1140 gct ctt gac gag gct ttg gac ttc ttc ttg ctg ata ttt gca acc gca 3510 Ala Leu Asp Glu Ala Leu Asp Phe Phe Leu Leu Ile Phe Ala Thr Ala 1145 1150 1tt 1160 gtg gca tgg gct gac cac act gcc cct ctc ctc ctc ggc ctc agt 3558 Val Val Ala Trp Ala Asp His Thr Ala Pro Leu Leu Leu Gly Leu Ser 1165 1170 1175 gcc agt tgg ttg cca tgg cat cag gag aat ggc ccg gct gca 3606 Ala Ser Trp Leu Pro Trp His Gln Glu Asn Gly Pro Ala Gly Pro Val 1180 1185 1190 cca agc ttc ctt ggc agg agt cca atg cac agg gtc act ctg cag gag 3654 Pro Ser Phe Leu Gly Arg Ser Pro Met His Arg Val Thr Leu Gln Glu 1195 1200 1205 gtt ctc act ctc ctt ccc aat agc atg gct ctg ctg ctg cag aaa gag 3702 Val Leu Thr Leu Leu Pro Asn Ser Met Ala Leu Leu Leu Gln Lys Glu 1210 1215 1220 cca tgg aag gaa cag acc cag aag ttc att gac tgg cta ttc agc atc 3750 Pro Trp Lys Glu Gln Thr Gln Lys Phe Ile Asp Trp Leu Phe Ser Ile 1225 1230 1235 1240 atg gaa agc cct aaa gaa gcc ctc tca gcag cag ctt ttg 3798 Met Glu Ser Pro Lys Glu Ala Leu Ser Ala Gln Ser Arg Asp Leu Leu 1245 1250 1255 aaa gcc acc ctg ctg tcc ttg aga gtt ctc cca gag ttt aag aag aaa 3846 Lys Ala Thr Leu Leu Ser Leu Arg Val Leu Pro Glu Phe Lys Lys Lys 1260 1265 1270 gct gta tgg acc aga gca tat ggt tgg tgaacagttt tgcagtaacc 3893 Ala Val Trp Thr Arg Ala Tyr Gly Trp 1275 1280 agcagcattc tcagctggat gaggaaaacc atataagtgg aagaagtttt tcagaattca 3953 tgcctggtat tgctgagaca tgatgcagag agttaagggt catgaaaaga tggccacatc 4013 actgacagct tgacacatgc ctcctaagag aggagtgcat tgctttagta cccgggccag 4073 ttgagactga aacaggaact tg gattttct ttatttggct tgagttcaat gtggagattt 4133 tctttgtgaa agcttgaaga tattatcttc tccctgctaa attccagtaa aataatgttg 4193 tc 4195 <210> 46 <211> 4101 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (72) .. (2414) <400> 46 agagtggaca gcaattgtga agatcgccag agagttctgt gtttcatcac cgccgaaagg 60 ttaaaaaata a atc atg act gaa tct gcc tct agc aca agt ggt caa gag 110 Ile Met Thr Glu Ser Ala Ser Ser Thr Ser Gly Gln Gtt 1g ttt g gac tgg aaa gat gga gtg ggc acg tta 158 Phe Asp Val Phe Ser Val Met Asp Trp Lys Asp Gly Val Gly Thr Leu 15 20 25 cca gga agt gac tta aag ttt cgg gta aat gag ttt gga gcc ctg gaa 206 Pro Gly Ser Asp Leu Lys Phe Arg Val Asn Glu Phe Gly Ala Leu Glu 30 35 40 45 gtt att aca gat gag aat gag atg gaa aat gtt aaa aaa gca act gct 254 Val Ile Thr Asp Glu Asn Glu Met Glu Asn Val Lys Lys Ala Thr Ala 50 55 60 acc acc act tgg atg gta cca act gct caa gaa gcc ccg acc tct ccc 302 Thr Thr Thr Trp Met Val Pro Thr Ala Gln Glu Ala Pro Thr Ser Pro 65 70 75 ccg agc tcc agg ccc gta ttt cca cct gcc tac tgg aca tct cca cct 350 Pro Ser Ser Arg Pro Val Phe Pro Pro Ala Tyr Trp Thr Ser Pro Pro 80 85 90 gga tgt ccc aca gtc ttt tca gag aag act ggg atg cct ttc agg ttg 398 Gly Cys Pro Thr Va l Phe Ser Glu Lys Thr Gly Met Pro Phe Arg Leu 95 100 105 aag gat cca gtg aaa gta gaa ggg ctt cag ttc tgt gag aac tgt tgt 446 Lys Asp Pro Val Lys Val Glu Gly Leu Gln Phe Cys Glu Asn Cys Cys 110 115 120 125 cag tat ggc aac gta gat gag tgt ctt tct gga gga aac tat tgc agc 494 Gln Tyr Gly Asn Val Asp Glu Cys Leu Ser Gly Gly Asn Tyr Cys Ser 130 135 140 cag aat tgt gct cgg cac atc aaa gat aaa gat cag aag gaa gaa agg 542 Gln Asn Cys Ala Arg His Ile Lys Asp Lys Asp Gln Lys Glu Glu Arg 145 150 155 gac gta gaa gaa gac aat gag gaa gaa gat cct aag tgt agt cgg aag 590 Asp Val Glu Glu Glu Asp Glu Glu Glu Glu Asp Pro Lys Cys Ser Arg Lys 160 165 170 aaa aaa cca aaa tta tct ctg aaa gct gac aac aag gag gat gga gaa 638 Lys Lys Pro Lys Leu Ser Leu Lys Ala Asp Asn Lys Glu Asp Gly Glu 175 180 185 gag aga gat gat gaa atg gag aac aaa caa gat gta aga atc ctg agg 686 Glu Arg Asp Asp Glu Met Glu Asn Lys Gln Asp Val Arg Ile Leu Arg 190 195 200 205 ggt tcg cag aga gca cgg agg aaa aga cga ggg gat tcg gct gta cta Gly Ser Gln Arg Ala Arg Arg Lys Arg Arg Gly Asp Ser Ala Val Leu 210 215 220 aag cag ggt ttg cct cct aaa gga aag aaa gcg tgg tgc tgg gca tcc 782 Lys Gln Gly Leu Pro Pro Lys Gly Lys Lys Ala Trp Cys Trp Ala Ser 225 230 235 tac ctg gaa gag gag aaa gcg gtg gca gtg ccg gcg aag ctg ttc aag 830 Tyr Leu Glu Glu Glu Lys Ala Val Ala Val Pro Ala Lys Leu Phe Lys 240 245 250 gag cat caa tcc ttt cca tat aac gga ttc aaa gtt ggc atg 878 Glu His Gln Ser Phe Pro Tyr Asn Lys Asn Gly Phe Lys Val Gly Met 255 260 265 aaa tta gaa ggc gtg gat ccc gag cat cag tct gtg tac tgt gtc ctc 926 Lys Leu Glu Asp Glu His Gln Ser Val Tyr Cys Val Leu 270 275 280 285 acc gtc gcg gag gtt tgt gga tac cgg ata aag ctt cac ttt gat ggg 974 Thr Val Ala Glu Val Cys Gly Tyr Arg Ile Lys Leu His Phe Asp Gly 290 295 295 300 tat tct gat tgc tat gac ttc tgg gtg aat gca gac gct ctg gat atc 1022 Tyr Ser Asp Cys Tyr Asp Phe Trp Val Asn Ala Asp Ala Leu Asp Ile 305 310 315 cac cca gtt ggg tgg tgt gag aaa acc ggc cac aaac t cca 1070 His Pro Val Gly Trp Cys Glu Lys Thr Gly His Lys Leu His Pro Pro 320 325 330 aaa ggg tat aaa gaa gaa gaa ttc aat tgg cag acc tat ctt aag aca 1118 Lys Gly Tyr Lys Glu Glu Glu Phe Asn Trp Gln Thr Tyr Leu Lys Thr 335 340 345 tgt aaa gct caa gct gct cct aag tca tta ttt gaa aat cag aat ata 1166 Cys Lys Ala Gln Ala Ala Pro Lys Ser Leu Phe Glu Asn Gln Asn Ile 350 355 360 365 aca gtg atc cca tcg ggc ttt cga gtt ggt atg aag ctt gag gca gta 1214 Thr Val Ile Pro Ser Gly Phe Arg Val Gly Met Lys Leu Glu Ala Val 370 375 380 gac aaa aag aat ccc tca ttc atc tgt gtt gct acg gta aca gat atg 1262 Asp Lys Lys Asn Pro Ser Phe Ile Cys Val Ala Thr Val Thr Asp Met 385 390 395 gtg gac aat cgt ttc ttg gta cat ttt gac aac tgg gat gag agc tat 1310 Val Asp Asn Arg Phe Leu Val His Phe Asp Asn Trp Asp Glu Ser Tyr 400 405 410 gac tat tgg tgt gaa gca tca agt cca cat att cat cca gtt ggt tgg 1358 Asp Tyr Trp Cys Glu Ala Ser Ser Pro His Ile His Pro Val Gly Trp 415 420 425 tgt aag gaa cat aga aga acc ctt att ac t cca cca ggt tat cca aat 1406 Cys Lys Glu His Arg Arg Thr Leu Ile Thr Pro Pro Gly Tyr Pro Asn 430 435 440 445 gtg aaa cat ttt tct tgg gat aaa tac tta gaa gaa acc aat tct tta 1454 Val Lys His Phe Ser Trp Asp Lys Tyr Leu Glu Glu Thr Asn Ser Leu 450 455 460 cct gct cct gca aga gct ttc aaa gtg aaa cct cct cat gga ttc cag 1502 Pro Ala Pro Ala Arg Ala Phe Lys Val Lys Pro Pro His Gly Phe Gln 465 470 475 475 aaa aaa atg aag ctt gag gtt gta gac aaa agg aac cct atg ttt att 1550 Lys Lys Met Lys Leu Glu Val Val Asp Lys Arg Asn Pro Met Phe Ile 480 485 490 aga gta gca act gtg gca gac aca gat gat cac cgg gtaaaa gtt cac 1598 Arg Val Ala Thr Val Ala Asp Thr Asp Asp His Arg Val Lys Val His 495 500 505 ttt gat ggc tgg aac aat tgc tat gat tac tgg ata gat gca gat tct 1646 Phe Asp Gly Trp Asn Asn Cys Tyr Asp Tyr Trp Ile Asp Ala Asp Ser 510 515 520 525 cct gat att cac cct gta ggc tgg tgt tca aaa aca gga cat ccc ctt 1694 Pro Asp Ile His Pro Val Gly Trp Cys Ser Lys Thr Gly His Pro Leu 530 535 540 cag cct cct ttg agc ccc tta gaa tta atg gaa gct tca gaa cat ggt 1742 Gln Pro Pro Leu Ser Pro Leu Glu Leu Met Glu Ala Ser Glu His Gly 545 550 555 gga tgc tca acc ccg gga tgt aaa ggg att ggc cat ttc aag Gaga gc790 Cys Ser Thr Pro Gly Cys Lys Gly Ile Gly His Phe Lys Arg Ala 560 565 570 aga cat ctg ggc cct cac agt gct gcc aac tgt ccc tat tca gaa atc 1838 Arg His Leu Gly Pro His Ser Ala Ala Asn Cys Pro Tyr Ser Glu Ile 575 580 585 aat ttg aat aaa gac cgt att ttt cca gac cgc tta agt ggt gag atg 1886 Asn Leu Asn Lys Asp Arg Ile Phe Pro Asp Arg Leu Ser Gly Glu Met 590 595 600 605 cct ccg gct agt ccg tcatt aat aaa agg aca gat gca aat 1934 Pro Pro Ala Ser Pro Ser Phe Pro Arg Asn Lys Arg Thr Asp Ala Asn 610 615 620 gaa agc tct tct tcc cct gaa atc aga gac cag cat gct gat gat gtc 1982 Glu Ser Ser Ser Ser Pro Glu Ile Arg Asp Gln His Ala Asp Asp Val 625 630 635 aaa gaa gac ttt gaa gag aga aca gaa agt gaa atg aga aca tca cat 2030 Lys Glu Asp Phe Glu Glu Arg Thr Glu Ser Glu Met Arg Thr Ser His 640 645 650 gaa gcc aga ggt gcc cgg gaa gaa ccc acc gtc cag cag gca cag cgt 2078 Glu Ala Arg Gly Ala Arg Glu Glu Pro Thr Val Gln Gln Ala Gln Arg 655 660 665 cgg tca gct gtc ttt ctg tcc ttt aag tcc cca tgt ctg ccc 2126 Arg Ser Ala Val Phe Leu Ser Phe Lys Ser Pro Ile Pro Cys Leu Pro 670 675 680 685 ttg cgc tgg gag cag caa agc aaa ctt ctt cca act gtc gca gga atc 2174 Leu Arg Trp Glu Gln Gln Ser Lys Leu Leu Pro Thr Val Ala Gly Ile 690 695 700 cct gcc agt aaa gtt tcc aaa tgg agc aca gac gag gtg tca gaa ttt 2222 Pro Ala Ser Lys Val Ser Lys Trp Ser Thr Asp Glu Val Ser Glu Phe 705 710 715 ata cag agc tta cct ggg tgt gaa gaa cat gga aag gta ttt aaa gat 2270 Ile Gln Ser Leu Pro Gly Cys Glu Glu His Gly Lys Val Phe Lys Asp 720 725 730 gaa caa att gat gga gaa gca ttt cta ctt atg act caa aca gac att 2318 Glu Gln Ile Asp Gly Glu Ala Phe Leu Leu Met Thr Gln Thr Asp Ile 735 740 745 gtt aaa att atg agc att aaa ctg ggc cct gct ctc aaa att ttc aat 2366 Val Lys Ile Met Ser Ile Lys Leu Gly Pro Ala Leu Lys Ile Phe Asn 750 755 760 765 tcc atc ctg atg ttc aaa gct gca gag aag aat tct cac aat gaa ctt 2414 Ser Ile Leu Met Phe Lys Ala Ala Glu Lys Asn Ser His Asn Glu Leu 770 775 780 tgaagatg t attgatt gat gaattgga tgatt gatt gatt gatt gat gaattg ttatt gatt gat gaattgga agcacaagga cggttataac tcctaagtga gaagtctcca aaactcaaaa gagcaacact 2534 atcggattat ttatattact caagagacaa tatatatgaa ttcttatgaa agtgcttgag 2594 cttttaacca ggtactgtct aacaacagtc atcttttggt tctgttcact gagctaaatt 2654 tatctttgta aatctttttg agtctggggg gtggggggaa ggggggcttc attaattatt 2714 tatggtaatg gggggcagag taagaacttt tggcattttg taaacattgt tgaattctct 2774 ttcatgtaca ctgtttcttt ttcaatactt tcagaaacct ttttatataa tcaaatttca 2834 atttaaacca aattagtcga aacctggcta agtttagcca gtaggactgt tatctgtatt 2894 gttaattttg tgccatattt tgaattgcaa cattatgcta agtataactt tgcaagtcat 2954 gatattgcct aactgcttgt cataattgtc agggctgaat agttgtaaga atgacttttc 3014 tttgaatcag tatttttcct tttgcacgca ttatgaatat tactacataat tactacattacattacta tactacattacta tactacattacta atgaaatt gaaaaataaa 3134 atatataaac ataaataaat taggtagtgt attttgagtg gcatcagtct cactcatctt 3194 ggtgccccgg tgtttacaag agccagatgg tgtcagagga gtacgcagtt gtatgcagtt 3254 atggttgggg ggaatgtttg tgagggtctt gaactattta tgagatgatc ttgagcttct 3314 aattttcatt gatgaaattg tggtggttta cagagactaa gagctcattc tgtcaacaga 3374 aacactaatc tgtacagagc gctgtctcag gtcatgcatt gtcctccaaa cccaaaggtt 3434 tttttcaggg ttggctagag agcgagtatt gtgattttgc tgaaaagaca aggtgtgaag 3494 gagcaacttc agttgacaca aaatttgaaa tgctcacaga tcagggaggt gatttcccaa 3554 agtaattgcc caagaacctc cgttttggaa ggattccttt ttctgtagaa tactttgcct 3614 cgatatataa gcatacagat gcactttaaa tgaaaaccct tgattataaa ttgatagctg 3674 gtagtgtttc ttttgcaaga atgcatttct aaggcaaaag gtaaattatt ttgtccgtct 3734 tttgatgtac tttctgattc caggattgga tatttattca aggactattt taaaaataga 3794 aagtaagttt gtagcatgct gtctgaattc tggggtaagt tccacctctt ctttagttgc 3854 tttcgttttt tatgatgtag gacttccttt gatatccctg ttggaagtcc attagcagtc 3914 ctttgcattt gccaattcaa ggtaaaacag ggtcagtgac atctgca gtg tcccagtcat 3974 ttatttgcat gaatctgctt aaataagttt tttgttgctg ttttttcttt tttatgtttt 4034 gttcagaatt tgtacattca agttgtactt gttatatctg acatgaatga aataaaatct 4094 taattac 4101 <210> 47 <211> 3973 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (87) .. (1916) <400> 47 attagagaaa ggccgagatc tgtccagctg cggtgagagg aacgctgaat cgccgaagag 60 aattggctgc gcttccttgt ttgtga gct aga att aga atg gcg atc agt cca 113 Ala Arg Ile Arg Met Ala Ig cca gccag ag ccag ccag ccag agt 161 Arg Ser Asp Ala Thr Phe Ser Ser Gln Lys Ser Thr Pro Ser Glu Ser 10 15 20 25 cct cga aca aag aaa ttt cca cta act gaa gag gaa ata ttt tat atg 209 Pro Arg Thr Lys Lys Phe Pro Leu Thr Glu Glu Glu Ile Phe Tyr Met 30 35 40 aat tgt aga gct gcc tac tta act gtc ttc aaa agc agc ttg gaa aac 257 Asn Cys Arg Ala Ala Ala Tla Leur Thr Val Phe Lys Ser Ser Leu Glu Asn 45 50 55 att att tct aaa gat caa ctt tac tta gct ctt cag cat gca gga aga 305 Ile Ile Ser Lys Asp Gln Leu Tyr Leu Ala Leu Gln His Ala Gly Arg 60 65 70 aat cca tcc caa aag acc att aat aag tat tgg act cct caa act gcc 353 Asn Pro Ser Gln Lys Thr Ile Asn Lys Tyr Trp Thr Pro Gln Thr Ala 75 80 85 aaa ctg aat ttt gat gat ttt tgt ata att tta agg aag gaa aaa cct 401 Lys Leu Asn Phe Asp Asp Phe Cys Ile I le Leu Arg Lys Glu Lys Pro 90 95 100 105 act tca aaa gca gaa cta cta aaa tca ttt aag caa tta gat gta aat 449 Thr Ser Lys Ala Glu Leu Leu Lyu Sers Phe Lys Gln Leu Asp Val Asn 110 115 120 gat gat ggc tgt att tta cac act gac ctt tat aaa ttt cta aca aag 497 Asp Asp Gly Cys Ile Leu His Thr Asp Leu Tyr Lys Phe Leu Thr Lys 125 130 135 aga ggt gag aag atg act cga gaa gaa gta aat gcc ata ata aat ttg 545 Arg Gly Glu Lys Met Thr Arg Glu Glu Val Asn Ala Ile Ile Asn Leu 140 145 150 gct gat gta aat gct gat ggc aaa ttt gac tac atc aag ttt tgt aaa 593 Ala Asp Val Asn Ala Asp Gly Lys Phe Asp Tyr Ile Lys Phe Cys Lys 155 160 165 tta tat atg aca acc aac gag caa tgt ctc aag act aca cta gaa aaa 641 Leu Tyr Met Thr Thr Asn Glu Gln Cys Leu Lys Thr Thr Leu Glu Lys 170 175 180 185 cta gag gtt gac agt aaa ttg atg cgt cac cag ttt gga aac cac atc 689 Leu Glu Val Asp Ser Lys Leu Met Arg His Gln Phe Gly Asn His Ile 190 195 200 gaa ggg tcc cct gaa agg gac cca tca cca gta cca aaa cca tca cct 737 Glu Gly Ser Pro Glu Arg Asp Pro Ser Pro Val Pro Lys Pro Ser Pro 205 210 215 aaa atc aca aga aaa act gat cca gaa aca ttc tta aat aaa ggt gac 785 Lys Ile Thr Arg Lys Thr Asp Pro Glu Thr Phe Leu Asn Lys Gly Asp 220 225 230 acc agg agt tct tta ctg tca gca acc agg aag ttc aaa aca tct gtt 833 Thr Arg Ser Ser Leu Leu Ser Ala Thr Arg Lys Phe Lys Thr Ser Val 235 240 245 tcc ttc aca gtt acc atg ggg gct aat ggt aac cga aac tca aag tta 881 Ser Phe Thr Val Thr Met Gly Ala Asn Gly Asn Arg Asn Ser Lys Leu 250 255 260 265 atg gag cca aat tta ata aag gac tgg caa cac atg caa tca aaa ggt 929 Met Glu Pro Asn Leu Ile Lys Asp Trp Gln His Met Gln Ser Lys Gly 270 275 280 tgc ttc ttc tta gaa gaa gat ggt gaa atc att agt cat cag tac agg 977 Cys Phe Phe Leu Glu Glu Asp Gly Glu Ile Ile Ser His Gln Tyr Arg 285 290 290 295 atg caa agg tcc atg gtt tat cta aca att aag cca tta 1025 Met Gln Ile Ala Gln Arg Ser Met Val Tyr Leu Thr Ile Lys Pro Leu 300 305 310 aac ctg agt caa gtt gaa gga aaa cca tcc cct tgg tta tcc gtt gat 1073 Asn Leu S er Gln Val Glu Gly Lys Pro Ser Pro Trp Leu Ser Val Asp 315 320 325 act gcc ttg tat att ctc aag gaa aat gag agt caa gca aat cta cag 1121 Thr Ala Leu Tyr Ile Leu Lys Glu Asn Glu Ser Gln Ala Asn Leu Gln 330 335 340 345 ctt gtg tgt ttt acc gaa cta cga aat aga gaa gtg ttt gga tgg act 1169 Leu Val Cys Phe Thr Glu Leu Arg Asn Arg Glu Val Phe Gly Trp Thr 350 355 360 ggt gaa cta gga cct gga att tac tgg tta att cct tcc aca act ggc 1217 Gly Glu Leu Gly Pro Gly Ile Tyr Trp Leu Ile Pro Ser Thr Thr Gly 365 370 375 tgt agg ctg agg aaa aaa ata aaa cca gta aca gat gaa gcc caa ctt 1265 Cys Arg Leu Arg Lys Lys Ile Lys Pro Val Thr Asp Glu Ala Gln Leu 380 385 390 gta tat aga gat gaa aca ggg gaa tta ttc ctt aca aag gaa ttt aag 1313 Val Tyr Arg Asp Glu Thr Gly Glu Leu Phe Leu Thr Lys Glu Phe Lys 395 400 405 tct act tta tca gat ata ttt gaa gta att gat tta gat gga aat ggt 1361 Ser Thr Leu Ser Asp Ile Phe Glu Val Ile Asp Leu Asp Gly Asn Gly 410 415 420 425 ctt ctt agc ctt gaa gaa tat aat ttt ttt gaa ttg aga aca agt ggt 1409 Leu Leu Ser Leu Glu Glu Tyr Asn Phe Phe Glu Leu Arg Thr Ser Gly 430 435 440 gag aaa tgt gat gaa gat gct tgg gct gtc tgc aga gag aat ttt gat 1457 Glu Lys Cys Asp Glu Asp Ala Trp Ala Cyla Arg Glu Asn Phe Asp 445 450 455 aca aag agg aat gaa cta aca aga caa gga ttt atg gat ttg aat cta 1505 Thr Lys Arg Asn Glu Leu Thr Arg Gln Gly Phe Met Asp Leu Asn Leu 460 465 470 470 atg gaa gga aat gat gaa gga gat cct tgt gac ctt tgg gta act 1553 Met Glu Ala Asn Asp Arg Glu Gly Asp Pro Cys Asp Leu Trp Val Thr 475 480 485 cta cac tct atg ggc tac aat aaa gct ctg gag ttg aca gag gca tgt 1601 Leu His Met Gly Tyr Asn Lys Ala Leu Glu Leu Thr Glu Ala Cys 490 495 500 505 cca ttt gtc att gat atc tat gca gaa aaa tgc aag cca aaa att aaa 1649 Pro Phe Val Ile Asp Ile Tyr Ala Glu Lys Cys Lys Pro Lys Ile Lys 510 515 520 gct gtc cat atg gag gca tgt agt gga caa ctt gag aag gcc att tgt 1697 Ala Val His Met Glu Ala Cys Ser Gly Gln Leu Glu Lys Ala Ile Cys 525 530 535 aaa tct gtt ctt agc aac ggt gat gcc aaa gta atg gat ggc tat gaa 1745 Lys Ser Val Leu Ser Asn Gly Asp Ala Lys Val Met Asp Gly Tyr Glu 540 545 550 aat ata atc gtg cat act tac agt tgt gac acc tgg ata acg tca gtt 1793 Asn Ile Ile Val His Thr Tyr Ser Cys Asp Thr Trp Ile Thr Ser Val 555 560 560 565 att gaa aac aag tca gat gag aaa gtg att att cac atc agc aat gag 1841 Ile Glu Asn Lys Ser Asp Glu Lys Val Ile Ile His Ile Ser Asn Glu 570 575 580 585 585 cta agt aaa aac tgc ata aac aac aga gga ctc aac ata ttt gca gta 1889 Leu Ser Lys Asn Cys Ile Asn Asn Arg Gly Leu Asn Ile Phe Ala Val 590 595 600 gaa gtg gga ccc aaa tct aca atg cct tgaacggaaa gata Gly Pro Lys Ser Thr Met Pro 605 610 cagctgccag tcttttggtt gtacaacaag aaggtctgga caatgagaac cctttttcta 1996 gattggttcc atcaatgctt tgtcgctgaa gtcaggaagt actttgccag taagcgacca 2056 ccttttacag tttttttgat ctggcacaat gtccctggcc acacggaacc ccatgattca 2116 acactgaagg tgtcaatgag gtctacttgc tccccaaaac aaggttccta attcaaccta 2176 tagattggag gtcatgaggg cctttaagtc tcatttcacg tgggaggtac tctgt ggaaa 2236 ggaatgtcaa cgctatggat gagaaccccc aatagagaga aaccatgata tgaagccgag 2296 atggcctttt agaaaagaaa actatataaa aataaaacac tgaaagatta aaacaacaat 2356 aacaaaagga catcataaaa gtctataaag ataataccat tgattatgct acagaaaaag 2416 ccatgaaagt catcaaacct gaaacaataa attcctgatg gagaaaactg tgtccagatg 2476 ttgtgcatca tttcacagaa tttatgacag acctaatcaa agaaatgaaa gacgtggata 2536 tggccaaaaa aaaaaaaaaa aaaaaagtgg gaggtgaaag gttttaagat atggatcttg 2596 gagaaattca agacaccaca ccagaggagt taagacaaca ggagagagtt gagtgattct 2656 gaaccagtgc caaatgatgt ggaagaagac atagaagaag cagtgccagg aaacaaaatg 2716 acatgagaca gtctggcata agggttctga ttattcaaga tcacttttga cttcttttgc 2776 aacatggaaa ctaaagcaaa cagtggaaga tggattgtac tgtatagaaa catttttaga 2836 gaaatgagaa agcaaaaaag tcagacaaaa attacagtgt agccgggtgt ggtggctcat 2896 gcctatatct cagcactttg ggaggctgag gtggaaggat tgcttgagga caggagttca 2956 agatcagcct gggcaacatg gtaagacatt gtctctacaa aaaataaaat tagctgggca 3016 tggtggcaca cacctgtagt cccggctact catgaggctg aggccagagg atcacttgag 3076 cccaggagtt cgaggctgca gtgagctatg attgcaccac cgcaatccag cctgggcaat 3136 ggagcaagat cttgtcttga aaaaagaaaa aaattacagt gtatttccaa gttacaccaa 3196 gtgtgcctgc ctcttctgct tctgctactc ttgagacagc aagaccaact tctcttcttc 3256 caccttctat tcaacatgga gataatgagg atgaagactt atgatgatcc actttcactt 3316 aatgaacagt aaatatatgt tctcttatgg taacaaataa cattttcctt tctctagcta 3376 actttattgt ttatgttcca taaggcttct ggtcaacata ggctattagt agttaagttt 3436 ggggggagtc aaaagttatg gatagatttt ccacttgtgg gggtggttgg cattcataac 3496 ccccatatta tttcagggtc aactgtacat tgttgagcat ttttgtgact gcataaaatg 3556 gatgttggtc tgtagttttc ttaattggaa atgtctttgt cttgtttggg tatcagagta 3616 attctggcct cataagatga gttgggaatg ctttctcgtt ttctggaaaa gactgtaaaa 3676 ttggtgttat ttctttaaat gttcacttga atttctcatt agaaacatct aggcatgaag 3736 atttattttg gaagaggttt tttttttttt aatacaaatt caatttcttt aacagctaca 3796 ggatattcag tttacctatt cttggttgag ttttggtagt ttgtagtttt tgagcatttg 3856 gtccatttta tctaagttgt caaatttatg tgcatagaat tttttaaaat tgtcaatgca 3916 gtctgtagtg atatcccttt ttcatttctg atattaataa aatgtgtctct ctctgtt 3973 <210> 48 <211> 4156 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2208) <400> 48 gaa gca tgg aga agg cta gaa agg ttt gat att aaa ctg ctc tca gaa 48 Glu Ala Trp Arg Arg Leu Glu Arg Phe Asp Ile Lys Leu Leu Ser Glu 1 5 10 15 ttt tcc tct tgc cta gca gat cag cat ttg tat ttt agt cca tta atg 96 Phe Ser Ser Cys Leu Ala Asp Gln His Leu Tyr Phe Ser Pro Leu Met 20 25 30 gga aaa ata gct gat att gtt cat agg aac ttg gaa acc aca cag gac 144 Gly Lys Ile Ala Asp Ile Val His Arg Asn Leu Glu Thr Thr Gln Asp 35 40 45 tta agt tcc ttg tct gtc ttg atg gtc aac ata tct tct tta ata tca 192 Leu Ser Ser Leu Ser Val Leu Met Val Asn Ile Ser Ser Leu Ile Ser 50 55 60 cga cat ttt caa caa caa ctg gtg aac aaa aca gaa ctt ctt ttt gac 240 Arg His Phe Gln Gln Gln Leu Val Asn Lys Thr Glu Leu Leu Phe Asp 65 70 75 80 acc ata gat tct tct gag gtc aac gtt gca aaa agc ata gca aag ttt 288 Thr Ile Asp Ser Ser Glu Val Asn Val Ala Lys Ser Ile Ala Lys Phe 85 90 95 ctt cga aat gtt aga tat cgt tat caa cca cta tta gaa aga tgt aat 336 Leu Arg Asn Val Arg Tyr Arg Tyr Gln Pro Leu Leu Glu Arg Cys Asn 100 105 110 aac gta ttt tta agt aat gtg gac cac ctt gat ttg gat tcc atc agt 384 Asn Val Phe Leu Ser Asn Val Asp His Leu Asp Leu Asp Ser Ile Ser 115 120 125 aaa ata ctt agt gta tac aaa ttt cta caa ttt aat agt ttt gaa ttt 432 Lys Ile Leu Ser Val Tyr Lys Phe Leu Gln Phe Asn Ser Phe Glu Phe 130 135 140 att ata atg gct aaa aag aag cta act gaa atg att cct ctg tgt aat 480 Ile Ile Met Ala Lys Lys Lys Leu Thr Glu Met Ile Pro Leu Cys Asn 145 150 155 160 cat cct gct agc ttt gta aaa ttg ttt gta gca ttg gga ccc att gca 528 His Pro Ala Ser Phe Val Lys Leu Phe Val Ala Leu Gly Pro Ile Ala 165 170 175 gga cct gaa gaa aag aaa caa ctt aaa tca act atg tta ttg atg tca 576 Gly Pro Glu Glu Lys Lys Gln Leu Lys Ser Thr Met Leu Leu Met Ser 180 185 190 gag gac cta act ggc gag caa gcc ctg gca gtg ttg gga gca atg gga 624 Glu Asp Leu Thr Gly Glu Gln Ala Leu Ala Val Leu Gly Ala Met Gly 195 200 205 gat atg gaa agc aga aac tca tgt ctg att aaa aga gtt act tca gtt 672 Asp Met Glu Ser Arg Asn Ser Cys Leu Ile Lys Arg Val Thr Ser Val 210 215 220 ctg cat aaa cat ttg gat ggc tat aaa cca tta gag ttg ttg aag ata 720 Leu His Lys His Leu Asp Gly Tyr Lys Pro Leu Glu Leu Leu Lys Ile 225 230 235 240 act caa gaa ttg act ttt ctg cat ttc caa agg aag gag ttt ttt gcg 768 Thr Gln Glu Leu Thr Phe Leu His Phe Gln Arg Lys Glu Phe Phe Ala 245 250 255 aaa ctt aga gaa tta ctg ctt agt tat ttg aaa aat agt ttc ata cca 816 Lys Leu Arg Glu Leu Leu Leu Ser Tyr Leu Lys Asn Ser Phe Ile Pro 260 265 270 act gag gtg tct gtt ctg gtc cgt gct att tcc ctg ctc cct tct cct 864 Thr Glu Val Val Ser Val Leu Val Arg Ala Ile Ser Leu Leu Pro Ser Pro 275 280 285 cac ttg gac gaa gtg ggg ata tcc cga att gaa gcc gtt tta cca cag 912 His Leu Asp Glu Val Gly Ile Ser Arg Ile Glu Ala Val Leu Pro Gln 290 295 300 tgt gac cta aat aac ctg agt agt ttt gcc aca tct gtt tta aga t 960 Cys Asp Leu Asn Asn Leu Ser Ser Phe Ala Thr Ser Val Leu Arg Trp 305 310 315 320 att cag cat gat cac gtg tat ttg gat aat atg act gcg aaa caa ctg 1008 Ile Gln His Asp His Val Tyr Leu Asp Asn Met Th r Ala Lys Gln Leu 325 330 335 aaa cta ctt caa aaa tta gat cac tat ggt cgt cag aga cta caa cac 1056 Lys Leu Leu Gln Lys Leu Asp His Tyr Gly Arg Gln Arg Leu Gln His 340 345 350 agc aac agt ttg gatct tta cgg aag gaa ctt aaa tct ctc aaa gga 1104 Ser Asn Ser Leu Asp Leu Leu Arg Lys Glu Leu Lys Ser Leu Lys Gly 355 360 365 aac acg ttt cct gag tca ctt ctt gaa gaa atg att gct act tta cag 1152 Asn Thr Pro Glu Ser Leu Leu Glu Glu Met Ile Ala Thr Leu Gln 370 375 380 cat ttc atg gat gat att aat tac ata aat gtt ggg gag att gca tct 1200 His Phe Met Asp Asp Ile Asn Tyr Ile Asn Val Gly Glu Ile Ala Ser 385 390 395 400 ttt att tct agt act gat tac ctc agt act ttg cta cta gat agg ata 1248 Phe Ile Ser Ser Thr Asp Tyr Leu Ser Thr Leu Leu Leu Asp Arg Ile 405 410 415 gcc tca gtg gct gtt cag cag att gaa aag atc cat cct ttt aca atc 1296 Ala Ser Val Ala Val Gln Gln Ile Glu Lys Ile His Pro Phe Thr Ile 420 425 430 cct gct att att cgt cca ttc agc gta ttg aac tat gat cca cct caa 1344 Pro Ala Ile Ile Arg Pro Ph e Ser Val Leu Asn Tyr Asp Pro Pro Gln 435 440 445 agg gat gaa ttt ttg gga act tgc gtg caa cat ctt aat tct tac tta 1392 Arg Asp Glu Phe Leu Gly Thr Cys Val Gln His Leu Asn Ser Tyr Leu 450 455 460 ggt ata ttg gat cct ttt ata tta gtg ttt ctt ggt ttc tct ttg gcc 1440 Gly Ile Leu Asp Pro Phe Ile Leu Val Phe Leu Gly Phe Ser Leu Ala 465 470 475 480 480 aca ctt gaa tat ttt cca gaa gat ctg cta g aac atc 1488 Thr Leu Glu Tyr Phe Pro Glu Asp Leu Leu Lys Ala Ile Phe Asn Ile 485 490 495 aaa ttc tta gct aga ttg gat tct caa ctt gaa att tta tct cca tct 1536 Lys Phe Leu Ala Arg Leu Asp Ser Gln Le Ile Leu Ser Pro Ser 500 505 510 cga agt gca aga gtc cag ttt cat ctt atg gag tta aat aga tca gtc 1584 Arg Ser Ala Arg Val Gln Phe His Leu Met Glu Leu Asn Arg Ser Val 515 520 525 tgc ttg gaa tgc cct gag ttt cag att cca tgg ttt cat gac cgc ttc 1632 Cys Leu Glu Cys Pro Glu Phe Gln Ile Pro Trp Phe His Asp Arg Phe 530 535 540 tgt caa caa tat aat aaa ggt att ggt ggc atg gat gga aca caa cag 1680 Cys Gln Gln Tyr Asn Lys Gly Ile Gly Gly Met Asp Gly Thr Gln Gln 545 550 555 560 cag att ttt aaa atg tta gca gag gta cta gga gga atc aat tgt gta 1728 Gln Ile Phe Lys Met Leu Ala Glu Val Leu Gly Gly Ile Asn Cy Val 565 570 575 aaa gcc tcg gtt ctt acg cct tat tac cac aaa gta gat ttt gag tgt 1776 Lys Ala Ser Val Leu Thr Pro Tyr Tyr His Lys Val Asp Phe Glu Cys 580 585 590 atc ttg gat aaa aga aaa aaa cct ctt ccg tat gga agc cat aat ata 1824 Ile Leu Asp Lys Arg Lys Lys Pro Leu Pro Tyr Gly Ser His Asn Ile 595 600 605 gca ttg gga caa cta cca gaa atg ccc tgg gaa tca aat atc gaa ata 1872 Ala Leu Gly Gln Leu Pro Met Pro Trp Glu Ser Asn Ile Glu Ile 610 615 620 gtt gga tca agg ctg cca cca ggg gct gaa agg att gct ttg gaa ttt 1920 Val Gly Ser Arg Leu Pro Pro Gly Ala Glu Arg Ile Ala Leu Glu Phe 625 630 635 640 tt gat tca aaa gca atg ccc tgg gaa tca aat atc gaa ata gtt gga 1968 Leu Asp Ser Lys Ala Met Pro Trp Glu Ser Asn Ile Glu Ile Val Gly 645 650 655 tca agg ctg cca cca ggg gct gaa agg att gct ttgga tt ttg gat 2016 Ser Arg Leu Pro Pro Gly Ala Glu Arg Ile Ala Leu Glu Phe Leu Asp 660 665 670 tca aaa gca ctt tgt aga aat atc cct cac atg aaa gga aaa tct gct 2064 Ser Lys Ala Leu Cys Arg Asn Ile Pro His Met Lys Gly Lys Ser Ala 675 680 685 atg aaa aaa cga cat ttg gaa att ctg ggg tat cgt gta att cag att 2112 Met Lys Lys Arg His Leu Glu Ile Leu Gly Tyr Arg Val Ile Gln Ile 690 695 700 tcc cagg tttgaa aac tct atg gca ctg tca aca aag gat gct cgg 2160 Ser Gln Phe Glu Trp Asn Ser Met Ala Leu Ser Thr Lys Asp Ala Arg 705 710 715 720 atg gac tac ctg aga gaa tgt ata ttt gga gaa gtc aag tca tgt ttg 2 Asp Tyr Leu Arg Glu Cys Ile Phe Gly Glu Val Lys Ser Cys Leu 725 730 735 tagtttttat ttaaaatgaa tgttatcgtg tgttacattt ggacctattt taataaagtg 2268 gcctgtctca attaaaaaat aggtacaaat gtcctaaggt gggaacatgc ctggcatgtt 2328 tgagaataac aaaggatcca gtgtggctgg agcagaacaa gtggggagtg gggtgggagt 2388 gtataagaga aaagataaga gataacagag tcaaatacaa cctcttggct actctgagcg 2448 agatgagaag ccattggggg cttttcaagt aaggaa tgat atgaattcac attttaactg 2508 cgttactttg gctaccttgt tgagataaga aaagactacg atgaggcaaa tgtgtaagaa 2568 agaaaactct ttacgaggtc attgcaataa tccagacaac aatggatggt ggcttggaga 2628 gagtggtagc agtggaggta ataagaagta gtcagatttt ttggatgtat gttgaagata 2688 aaggcaacag aatttgctca ctgattggat atgaggtatg agacaaatag gagtcaagga 2748 taattctaag tttttgtcct aagcaactaa gaggatgtca ttagcattaa ctaagatggg 2808 gatagtctat aggaagagca agatgggggg caggtggtgg gggttgatca caagtttgtt 2868 ttagatatgt tgagtttgtg atgtctttta aacatctaag tggatatatc aaatagagaa 2928 ttcagtaaat gagcttggag gtcagggaag aggtccaggc cccagatata aatgtataaa 2988 tgtcagcagt attcaatgcc atgagagtag atgaaatcgc ttaaaatgag attagagaag 3048 agtgtgaatg gaggagaggt ctgaggactg agttttcaag tgccccaaca ttaaaagatt 3108 aagaggaaga ggaggaatca ggaaaggaga ctgagcaggg atggccaatg aggtaggagg 3168 aaggaaggta agtaatactt cctagaagcc aagtggataa agcatttcaa gggggaggtg 3228 agtagttgta tcagatgctg ctgataggtc aggaaagatg acaaatggga aatggctatt 3288 aaatttagca acatgaaaat cattagtact ttgaaaatag t cgttttgaa gtggtgcatg 3348 tgaaagcctg actggttcaa gagaaaatgg gaggagatac attttctcct aaatggaagc 3408 aaagaaatgg ggtagtagct gagtggacca tcttgacctg gtgtaatcct acacattgag 3468 ggaataatgg cttctccctg tcttacaaca catttattca ataaaatggt tactaagggc 3528 ctactgtgtg atataatccc caacccttcc tctaagagtg atggttttgt gctcagcagg 3588 ccacagccta actactctca gttacgccac ctggtggtgg tggaggtaat tgaccatctg 3648 aaccgtggct atcttctgac tccatgacct tctcaattca tactatctca aaataagttg 3708 gtagctggag tgccttcaat cataagcata gctttaaaat ttgtgtcttg catgtaaatt 3768 gcttcactga tgtttggctt aggcttagtt gaagtacatg tttaaaatat ccaatgactt 3828 tgcatgattt gaactccaat acttaatgat tttgtggaat attaacttca caaaacgttt 3888 tgtgaaaaac aaaatcagaa tagtaagtga aagatgtctc attgtctctt cctctttctg 3948 aatttcctca tagtcatatt agtggaaatg ctaaattcag tgtttaattt ccatgaaatg 4008 tgttctattt ctcaagcaag tgataacaag aactagacca ttgaataggt taaaatattt 4068 tactatgcaa ctttagaata aaatgattag gctgatgagg gttataaagg gtttcctttg 4128 gatataaatc attaaaaatt tagtcatt 4156 <210> 49 <211> 4021 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3683) <400> 49 aa aga aca aga ttt aaa gac caa caa gaa aaa gaa gaa ttt atg aga 47 Arg Thr Arg Phe Lys Asp Gln Gln Glu Lys Glu Glu Glu Phe Met Arg 1 5 10 15 agt aaa acc gat tgt gcc act cct gat ttt gtt cct gag cct agt cct 95 Ser Lys Thr Asp Cys Ala Thr Pro Asp Phe Val Pro Glu Pro Ser Pro 20 25 30 cat gac ttg cct atg gat gaa cat gtt tta cca gat gat gct gat ata 143 His Asp Leu Pro Met Asp Glu His Val Leu Pro Asp Asp Ala Asp Ile 35 40 45 aat ttt gga tac tgt gaa gtg gaa gaa aaa tgt aga cag tct ttt gag 191 Asn Phe Gly Tyr Cys Glu Val Glu Glu Lys Cys Arg Gln Ser Phe Glu 50 55 60 gct tgg caa gag aaa cag aag gaa tta gaa gat aaa gag aaa caa act 239 Ala Trp Gln Glu Lys Gln Lys Glu Leu Glu Asp Lys Glu Lys Gln Thr 65 70 75 ctc aaa gct cag agg gat aga gaa gaa aaa caa ttt caagaa 287 Leu Lys Ala Gln Arg Asp Arg Glu Glu Lys Gln Phe Gln Glu Glu Glu 80 85 90 95 gaa aag cga cat tgc tgg atg aaa caa ttt aaa gtt gaa aag aag aaa 335 Glu Lys Arg His Cys Trp Met Lys Gln Phe Lys Val Glu Lys Lys Lys 100 105 110 tta gag aac att cag aag caa gaa cag gac aag atg aat gat gaa ctc 383 Leu Glu Asn Ile Gln Lys Gln Glu Gln Asp Lys Met Asn Asp Glu Leu 115 120 125 tat aaa gaa gag aaa att tgg aaa gag aaa ttt aaa cag gag 431 Tyr Lys Glu Glu Lys Ile Trp Lys Glu Lys Phe Lys Gln His Glu Glu 130 135 140 tat att aga aac ttg cat tta caa atg gaa gaa gaa aga aca aga ttt 479 Tyr Ile Arg Asn Leu His Leu Gln Glu Glu Glu Glu Arg Thr Arg Phe 145 150 155 aaa gac caa caa gaa aaa gaa aaa aat tct ttg tta aaa cag cag aat 527 Lys Asp Gln Gln Glu Lys Glu Lys Asn Ser Leu Leu Lys Gln Gln Asn 160 165 170 175 aat gca gct gtt aaat caa gct aaa tat aaa gca ttt gta gcc tat 575 Asn Ala Ala Val Lys Ile Gln Ala Lys Tyr Lys Ala Phe Val Ala Tyr 180 185 190 caa aaa tat ggc cca att att aaa gag caa att gaa agt aag aaa agg 623 Gln Lysyr Gly Pro Ile Ile Lys Glu Gln Ile Glu Ser Lys Lys Arg 195 200 205 aaa gca caa gag tgg aag gaa aag gaa gca aaa ata cga caa aag gag 671 Lys Ala Gln Glu Trp Lys Glu Lys Glu Ala Lys Ile Arg Gln Lys Glu 210215 220 gaa gaa aat cga aaa aga tta gag gag gaa caa agg ata aaa gaa gag 719 Glu Glu Asn Arg Lys Arg Leu Glu Glu Glu Gln Arg Ile Lys Glu Glu 225 230 235 aga aaa aag caa aag aga agg agaa gaa aaa gaa tat 767 Arg Lys Lys Gln Lys Glu Glu Glu Arg Lys Arg Arg Glu Lys Glu Tyr 240 245 250 255 gaa gaa aaa aag aat att gtg aaa cag gaa aga gag caa cta ata agc 815 Glu Glu Lys Lys As Gln Glu Arg Glu Gln Leu Ile Ser 260 265 270 aag gaa aaa ata ata tta aga gaa gat gca agc caa cag cta ata ata 863 Lys Glu Lys Ile Ile Leu Arg Glu Asp Ala Ser Gln Gln Leu Ile Ile 275 280 ggt agt tta aag aag agc gga tat aat aac aaa cat tta agt ctt 911 Ser Ser Ala Leu Lys Lys Ser Gly Tyr Asn Asn Lys His Leu Ser Leu 290 295 300 gaa gat att tca aat gat aag ggt gat ata gcc aaa aat cta gtg gat 959 Glu Asp Ile Ser Asn Asp Lys Gly Asp Ile Ala Lys Asn Leu Val Asp 305 310 315 gaa aat tca aag aag cag gaa gat gtt ctc ctt tgg cta gtt gag gaa 1007 Glu Asn Ser Lys Lys Gln Glu Asp Val Leu Leu Trp Leu Val Glu Glu 320 325 330 335 tca aat atg aaa gaa aat gta gat aga cag act ata tta aaa gaa tca 1055 Ser Asn Met Lys Glu Asn Val Asp Arg Gln Thr Ile Leu Lys Glu Ser 340 345 350 350 ata caa gta aag tta aaa gaa tct ata tca agc caa aca att ctg gca 1103 Ile Gln Val Lys Leu Lys Glu Ser Ile Ser Ser Gln Thr Ile Leu Ala 355 360 365 gat ttt aaa atg gaa gaa aaa aat gaa aac cta gca aaa aaa cga tgt 1151 Asp Phe Lys Met Glu Glu Lys Asn Glu Asn Leu Ala Lys Lys Arg Cys 370 375 380 tca gaa gaa ttg gtc aag caa gaa aga aaa tat gaa aat aca gat aac 1199 Ser Glu Glu Leu Val Lys Gln Glu Arg Lys Tyr Glu Asn Thr Asp Asn aaa act gaa ttg gga aac tct gat cta aaa gga aat ctg aaa gaa cag 1247 Lys Thr Glu Leu Gly Asn Ser Asp Leu Lys Gly Asn Leu Lys Glu Gln 400 405 410 415 ttt cca ttg caa gaa tta aag tct gat gca ca gaa aaa atc 1295 Phe Pro Leu Gln Glu Leu Lys Ser Asp Ala Gln Lys Glu Glu Lys Ile 420 425 430 atg aaa cat gtc ata aat gag aat aca gga caa aaa acc cag ata ata 1343 Met Lys His Val Ile Asn Glu Asn Thr Gly Gln Lys Thr Gln Ile Ile 435 440 445 tta gga cat aac caa gaa atc agt gag gtg aaa acc aat gaa gag cag 1391 Leu Gly His Asn Gln Glu Ile Ser Glu Val Lys Thr Asn Glu Glu Gln 450 455 460 aaa aaa ata atc aaa gat aat cag cag aaa aag ata caa aaa gta gaa aaa 1439 Lys Ile Ile Lys Asp Asn Gln Gln Lys Lys Ile Gln Lys Val Glu Lys 465 470 470 475 gaa gag ata caa gaa cag aat gga tta tta tat tat gat agat ag Glu Glu Ile Gln Glu Gln Asn Gly Leu Leu Tyr Lys Asp Lys Asp Thr 480 485 490 495 tta gtt att tca gtg aaa caa aga tca ctc tca cta aca tca gaa aat 1535 Leu Val Ile Ser Val Lys Gln Arg Ser Leu Ser Leu Thr Ser Glu Asn 500 505 510 tcc aaa gat gta aga gaa aac gta ata tta caa gaa aaa gaa att tat 1583 Ser Lys Asp Val Arg Glu Asn Val Ile Leu Gln Glu Lys Glu Ile Tyr 515 520 525 tca aaa tcc aaa gaa att gag aac cca aaa gac aat gct tgg aat 1631 Ser Lys Ser Lys Glu Ile Glu Glu Asn Pro Lys Asp Asn Ala Trp Asn 530 535 540 agt ggc att gtg att ttt aac aca act gat acc atg ata aat ata gaa 1679 Ser Gly Ile Val Ile Phe Asn Thr Thr Asp Thr Met Ile Asn Ile Glu 545 550 555 ggc aaa aga aat gac caa gat tat gtg tta ggt aga cat gct cct tgt 1727 Gly Lys Arg Asn Asp Gln Asp Tyr Val Leu Gly Arg His Ala Pro Cys 560 565 570 575 gag ggc ttg agt aac tat aat gca gaa agc tcc atg gta tct aaa gaa 1775 Glu Gly Leu Ser Asn Tyr Asn Ala Glu Ser Ser Met Val Ser Lys Glu 580 585 590 gtc aac tct ctt aaa tct atg attaga tca gaa aaa tgc cat 1823 Val Asn Ser Leu Lys Ser Glu Ile Arg Asn Ile Ser Glu Lys Cys His 595 600 605 gaa aat gca cct gaa cct gat agc atg acc tgc tgt gta tca gag tca 1871 Glu Asn Ala Pro Glu Pro Asp Ser Met Thr Cys Cys Val Ser Glu Ser 610 615 620 acc ctt cta tat tct att gaa gaa agg aga cta gcc tgg ata aaa tca 1919 Thr Leu Leu Tyr Ser Ile Glu Glu Arg Arg Leu Ala Trp Ile Lys Ser 625 630 635 ttt aaa cct tgg ctt gaa att ttc aag caa aat caa caa aag aaa att 1967 Phe Lys Pro Trp Leu Glu Ile Phe Lys Gln Asn Gln Gln Lys Lys Ile 640 645 650 655 655 gtt aga aga aag aga cct gtg aaa tgc cca gcc aac atg c gct 2015 Val Arg Arg Lys Arg Pro Val Lys Cys Pro Ala Asn Met Thr Pro Ala 660 665 670 ttg gat aaa ctg gaa att ctt cga tgt ggc cct tgg gat act tta cag 2063 Leu Asp Lys Leu Glu Ile Leu Arg Cys Gly Pro Trp Asp Thr Leu Gln 675 680 685 cag gtt aca aca gtt aca ttt caa gat ttg cca ggc tgt gtt ctc tcc 2111 Gln Val Thr Thr Val Thr Phe Gln Asp Leu Pro Gly Cys Val Leu Ser 690 695 700 aca ctg gca gag tgt aca aat ctt cag ttt cta tcc ctt cga cgc tgt 2159 Thr Leu Ala Glu Cys Thr Asn Leu Gln Phe Leu Ser Leu Arg Arg Cys 705 710 715 gga tta act tct ttg cac agc ctg agt aat tgt aaa aaa ctt aag tac 2207 Gly Le Ser Leu His Ser Leu Ser Asn Cys Lys Lys Leu Lys Tyr 720 725 730 735 att gat gca cag gaa aac cat att gag gct att gag tgt gaa aat ttg 2255 Ile Asp Ala Gln Glu Asn His Ile Glu Ala Ile Glu Cys Glu Asn Leu 740 745 750 gaa aat ctc tgt gtt gtt ctt ctt aat aaa aat caa ctg act tct ctt 2303 Glu Asn Leu Cys Val Val Leu Leu Asn Lys Asn Gln Leu Thr Ser Leu 755 760 765 cat ggt ttg gat ggc tgt act aat att cag tgt ctt gaa ctt tca tat 2351 His Gly Leu Asp Gly Cys Thr Asn Ile Gln Cys Leu Glu Leu Ser Tyr 770 775 780 aat aaa att act cga att gga tat tcc ttc ttt ctg gaa gaa aaa ctt 2399 Asn Lys Ile Gle Ile Thr Arg Tyr Ser Phe Phe Leu Glu Glu Lys Leu 785 790 795 gtt gac aat aca ggg ttc tgc cat cac ttg ggc acc tcc act tct tac 2447 Val Asp Asn Thr Gly Phe Cys His His Leu Gly Thr Ser Thr Ser Tyr 800 805 810 815 815 tta tcc ctg gca caa gtc tgg att cca act gga tta tgt tgg tcc tgg 2495 Leu Ser Leu Ala Gln Val Trp Ile Pro Thr Gly Leu Cys Trp Ser Trp 820 825 830 ata cct att acc tca ctt aca aaa aat tca gat tgt aat ttc ctt atc 2543 Ile Pro Ile Thr Ser Leu Thr Lys Asn Ser Asp Cys Asn Phe Leu Ile 835 840 845 tcc cac tta tac tgg aat tgt ggt tta gaa tct ttg aaa aat ctt caa 2591 Ser His Leu Tyr Trp Asn Cys Gly Leu Glu Ser Leu Lys Asn Leu Gln 850 855 860 caa cta att ttg gac cac aat cag tta att aat aca aaa ggt ctt tgt 2639 Gln Leu Ile Leu Asp His Asn Gln Leu Ile Asn Thr Lys Gly Leu Cys 865 870 875 875 gat aca cct acc att gta tac cta gat tgc tcc cat aat cat ctt act 2687 Asp Thr Pro Thr Ile Val Tyr Leu Asp Cys Ser His Asn His Leu Thr 880 885 890 895 gat gta gag ggc gtt gaa aat tgt gga ttg ctc caa ata ttg aag tta 2735 Asp Val Glu Gly Val Glu Asn Cys Gly Leu Leu Gln Ile Leu Lys Leu 900 905 910 cag gga aat tat ctg agt gag ctt cca tcc ttg gag aat ctt gtt tta 2783 Gln Gly Asn Tyr Leu Ser Glu Leu Pro Ser Leu Glu Asn Leu Val Leu 915 920 925 cta aga gaa ttg cac ttg gat gat aac agc att tca act gtg gaa gca 2831 Leu Arg Glu Leu His Leu Asp Asp Asn Ser Ile Ser Thr Val Glu Ala 930 935 940 ttt tct tca tac tgg ctg ccttta aat att act atc tct caa 2879 Phe Ser Ser Tyr Trp Leu Pro Leu Leu Gln Asn Ile Thr Ile Ser Gln 945 950 955 aac agc ttg act aaa atc gta cca ctt ttt cat ttt gtt tca ttg gaa 2927 Asn Ser Leu Thr Lys Ile Val Pro Leu Phe His Phe Val Ser Leu Glu 960 965 970 975 aag cta gat gtc agc cac aat tgt ctt tct gat ctt aaa agt gcc ata 2975 Lys Leu Asp Val Ser His Asn Cys Leu Ser Asp Leu Lys Ser Ala Ile 980 985 990 aaa tgg ttt gat gca tgc tat tct ctc cat gaa ttg tct ctt act gga 3023 Lys Trp Phe Asp Ala Cys Tyr Ser Leu His Glu Leu Ser Leu Thr Gly 995 1000 1005 aac cca ctt ctt caa gaa aca aac tgg agg gat tct c ctt aaa gtg 3071 Asn Pro Leu Leu Gln Glu Thr Asn Trp Arg Asp Ser Leu Leu Lys Val 1010 1015 1020 ttg cct gct ctg aga atc ctc aat ggc aat ata cta aac tct aat tca 3119 Leu Pro Ala Leu Arg Ile Leu Asn Gly Ile Leu Asn Ser Asn Ser 1025 1030 1035 gaa agc cgc act gaa gaa cac aat caa ctg gga tca gca ggt ttc ctg 3167 Glu Ser Arg Thr Glu Glu His Asn Gln Leu Gly Ser Ala Gly Phe Leu 1040 1045 1050 1055 gcatt tct cag att cga gaa ttc aac ttg cta att gaa aat 3215 Ala Leu Cys Gln Ser Gln Ile Arg Glu Phe Asn Leu Leu Ile Glu Asn 1060 1065 1070 tat ata act gga aaa gga gat gta ttt acc ttg gat act gca gaaat Ile Thr Gly Lys Gly Asp Val Phe Thr Leu Asp Thr Ala Glu Asn 1075 1080 1085 ctc tgt cat tat ttt aag aaa ttg atg ata ctt agt act gaa tac cga 3311 Leu Cys His Tyr Phe Lys Lys Leu Met Ile Leu Ser Thr Glu Tyr Arg 1090 1095 1100 cat gca cac gaa cga ggg gat gta act atc acc aag aaa gat gaa tca 3359 His Ala His Glu Arg Gly Asp Val Thr Ile Thr Lys Lys Asp Glu Ser 1105 1110 1115 gaa gcc cag aaa aat cat ttg gcc cct aca aac agt gac agc act ctg 3407 Glu Ala Gln Lys Asn His Leu Ala Pro Thr Asn Ser Asp Ser Thr Leu 1120 1125 1130 1135 caa aat gga gtc ttc tac tct tgt gca cgt gaa ggt gag cca gac tca 3455 Gln Asn Gly Val Phe Tyr Ser Cys Ala Arg Glu Gly Glu Pro Asp Ser 1140 1145 1150 cca gat att cct gag aaa tgg atg gac tct gtc tcc agc cac tcc cca 3503 Pro Asp Ile Pro Glu Lys Trp Met Asp Ser Val Ser Ser His His Ser Pro 1155 1160 1165 tta agc aaa tcc gcc aca tgt gaa aat atg gaa gga aga cat cag gaa 3551 Leu Ser Lys Ser Ala Thr Cys Glu Asn Met Glu Gly Arg His Gln Glu 1170 1175 1180 ata tta gta tgt cag aag agaa gac agc aag gca agc agt att ccc 3599 Ile Leu Val Cys Gln Lys Arg Glu Asp Ser Lys Ala Ser Ser Ile Pro 1185 1190 1195 acc ata aga atc cca ttt aag gaa gta gta atg aca aat tct ttg ctg 3647 Thr Ile Arg Ile Pro Phe Lys Glu Val Val Met Thr Asn Ser Leu Leu 1200 1205 1210 1215 agg aat cac caa aat att gag cct agt gaa aaa atg taagatatat 3693 Arg Asn His Gln Asn Ile Glu Pro Ser Glu Lys Met 1220 1225 aaataatt tcttttatag atgtatgttt actccttttg atggatgata ttagtcaatg 3753 gtacctagta atttgctgaa ggattcaaat cacaatcata tttcataccg attccattat 3813 gttttcgtga ggtgcattat gttttcatga ggtgcacaaa tcattaatta tagtgcatat 3873 taatttgatt aaattctcat ttaatttcta gtagtattta aatgagtaaa tgtgagtttt 3933 tttctgcctt gtaatttcta aataattaat atgttttaag gagaaataaa atatcacagt 3993 ctaaaaataa taaaaacatt ttctgagt 4021 <210> 50 <211> 3748 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1389) <400> 50 gtt ctg caa gcc tac atc agc aat gac ctc ttg gac tgt tat agc cac 48 Val Leu Gln Ala Tyr Ile Ser Asn Asp Leu Leu Asp Cys Tyr Ser His 1 5 10 15 aac cag agg agt gtg ctt cag ttg ctg cac tcc acg agc gac gtg gtg 96 Asn Gln Arg Ser Val Leu Gln Leu Leu His Ser Thr Ser Asp Val Val 20 25 30 cgg cag tac atg gcc agg ctc atc aat gct ttt gcg tca ctg gca gaa 144 Arg Gln Tyr Met Ala Arg Leu Ile Asn Ala Phe Ala Ser Leu Ala Glu 35 40 45 ggt cgc ctc tac ctt gcc cag aac aca aag gtg ctg cag atg ctg gag 192 Gly Arg Leu Tyr Leu Ala Gln Asn Thr Lys Val Leu Gln Met Leu Glu 50 55 60 gga agg ctg aag gag gag gac aag gat atc atc acc agg gag aat gtt 240 Gly Arg Leu Lys Glu Glu Asp Lys Asp Ile Ile Thr Arg Glu Asn Val 65 70 75 80 ctt ggg gcc ctg cag aag ttc agt ctc agg cgc ccg ccg cag aca gcg 288 Leu Gly Ala Leu Gln Lys Phe Ser Leu Arg Arg Pro Leu Gln Thr Ala 85 90 95 atg att caa gac ggc ctc atc ttc tgg ctg gtt gat gtt ctg aag gac 336 Met Ile Gln Asp Gly Leu Ile Phe Trp Leu Asp Val Leu Lys Asp 100 105 110 cct gac tgc ctg tct gac tac acg ctg gag tac tcg gtg gct ttg ctc 384 Pro Asp Cys Leu Ser Asp Tyr Thr Leu Glu Tyr Ser Val Ala Leu Leu 115 120 125 atg aac ctc tgc ctc cgc agc aca ggg agag ag agc aag gtg 432 Met Asn Leu Cys Leu Arg Ser Thr Gly Lys Asn Met Cys Ala Lys Val 130 135 140 gca ggc ctc gtg ctc aaa gtc ctt tcg gat ctt ctt ggc cat gaa aac 480 Ala Gly Leu Val Leu Lys Val Leu Serp Leu Gly His Glu Asn 145 150 155 160 cat gag ata cag ccg tat gtg aat gga gct ctg tac agc atc ctt tct 528 His Glu Ile Gln Pro Tyr Val Asn Gly Ala Leu Tyr Ser Ile Leu Ser 165 170 175 gtt cca tcc att cgt gag gaa gca aga gca atg gga atg gaa gac atc 576 Val Pro Ser Ile Arg Glu Glu Ala Arg Ala Met Gly Met Glu Asp Ile 180 185 190 cta cgc tgc ttc atc aaa gaa ggc aat gct gaa atg atc cgccag ata cg624 Cys Phe Ile Lys Glu Gly Asn Ala Glu Met Ile Arg Gln Ile 195 200 205 gaa ttc atc atc aag cag cta aat tcc gaa gag cta cca gat ggt gtt 672 Glu Phe Ile Ile Lys Gln Leu Asn Ser Glu Glu Leu Pro Asp Gly 210 215 220 ctt gaa tct gat gat gat gaa gat gaa gat gat gaa gag gac cat gac 720 Leu Glu Ser Asp Asp Asp Glu Asp Glu Asp Asp Glu Glu Asp His Asp 225 230 235 240 atc atg gaa gcc gat ctg gac aaa gac ctg atc cag ccc cag ctc 768 Ile Met Glu Ala Asp Leu Asp Lys Asp Glu Leu Ile Gln Pro Gln Leu 245 250 255 gga gaa ctc tca gga gag aag ctt ctg acc acg gag tac ctg ggg atc 816 Gly Glu Leu Ser Gly Leu Leu Thr Thr Glu Tyr Leu Gly Ile 260 265 270 atg acc aac acg ggg aag aca agg cgg aag ggg ctg gct aat gtg cag 864 Met Thr Asn Thr Gly Lys Thr Arg Arg Lys Gly Leu Ala Asn Val Gln 275 280 280 tgg agc ggg gat gag ccc ctg caa agg ccc gtc acc ccc ggc ggc cac 912 Trp Ser Gly Asp Glu Pro Leu Gln Arg Pro Val Thr Pro Gly Gly His 290 295 300 aga aac ggg tac cca gtg gtg gaa gac caa cac aca cct ccc cagca 960 Arg Asn Gly Tyr Pro Val Val Glu Asp Gln His Thr Pro Pro Gln Thr 305 310 315 320 gcc cag cac gcc aga aac ggc cac ccg cag gcc ctg cca gcc gct cac 1008 Ala Gln His Ala Arg Asn Gly His Pro Gln Ala L eu Pro Ala Ala His 325 330 335 gag gct gtc tac agg gag ggc aag ccc agc acc ccg gag tcc tgc gtc 1056 Glu Ala Val Tyr Arg Glu Gly Lys Pro Ser Thr Pro Glu Ser Cys Val 340 345 350 tcc tct tca tca gcc atc atc gcc aag cca gga gag tgg ctc cca aga 1104 Ser Ser Ser Ser Ala Ile Ile Ala Lys Pro Gly Glu Glu Trp Leu Pro Arg 355 360 365 gga cgc cag gaa gag cct cgc cca gcc ccc acg ggg acc ccc cgc cag 1152 Gly Arg Gln Glu Glu Pro Arg Pro Ala Pro Thr Gly Thr Pro Arg Gln 370 375 380 cca agg gag gcg ccc cag gac cca ggc aat gga gtg acc acc agg gaa 1200 Pro Arg Glu Ala Pro Gln Asp Pro Gly Asn Gly Val Thr Thr Arg Glu 385 390 395 400 tgt gca tca gcc ttc acc tgc aag ccc cgg gcc ccc tgc act cca gag 1248 Cys Ala Ser Ala Phe Thr Cys Lys Pro Arg Ala Pro Cys Thr Pro Glu 405 410 415 atg ctg gac tgg aac cca ccc aag gca aag gcg tca gtt ctg gcc cct 1296 Met Leu Asp Trp Asn Pro Pro Lys Ala Lys Ala Ser Val Leu Ala Pro 420 425 430 ctg ttc tct tcg tgt ggc ccc cag cag gcc agc cgc ccc ggc tcc aca 1344 Leu Phe Ser Ser Cys G Pr o Gln Gln Ala Ser Arg Pro Gly Ser Thr 435 440 445 gcg tcc tcc aca agg ggc ctg ccg agc agc cag tct cac agg aag 1389 Ala Ser Ser Thr Thr Arg Gly Leu Pro Ser Ser Gln Ser His Arg Lys 450 455 460 taaggatgtc cccgggtgtcccgtc tgccggagga ccagccagct tcccgctctc 1449 agctggcagc agctgccggt gatggatgtg aagggacagt tgtccacaag actctgggag 1509 ctgaggggag gccggctctc caggcagcac cagagcaagg ccatcgcagc cccgccagcc 1569 gggtcacttt ctcccagggc agagccacca aggagggctg gggagagcct ggcattgccc 1629 tcctggagag gggaatttcc tgctcaccct tcacacacag aggagagggg tggcttttgc 1689 ccgcaggaga tcttctggcc ccagaaacag caggtgctgg atttgcagcc ctggccctcc 1749 aggccccaac agggcgacag tgtagggcca gcctggagca gggcttttcc aaggctgctg 1809 aagccagccc tcctcacttg ggctgactac caggacccag aaggaactca gggtgaagct 1869 cattttattc tcaagcctgc gtctcagcag caaagttggt gttttcttcc tgtgttaaaa 1929 tctgagaaag aaggccaggt gcggtggctc acgcctgtaa ttccaggact ttggaaggct gg ggagcag 1989 gaggcgag 1989 gccgggcgtg gtggcgggcg cttgtagtcc 2109 cagctactct ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt 2169 gagccgagat cgtgccactg cactctagcc tgggtgacag agcgagactc cgtccccaaa 2229 aaaaaaattc tgagaatatg gtgtgttcca gcctcttcaa agctctgctc ttctgcacac 2289 gttttttgaa ggccttaaaa aggccaccag tgtgaccagg gagcaccctc tgcctccctc 2349 cctgcactgg gaccataaac ataaacagct ctaccagcaa agtgacccat cccgcggggg 2409 aggcctgcgc acgcccctca ccagggctgt catcagaatc cagtcttagg acagaggaag 2469 gatgtttgcc ttcaggacca gcaagtcaca ggtgtcctgg atgttaccca agctctaaaa 2529 tcaaataaaa cccatcagta tttagtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 2589 tgtgtgtgtg tgtgtgtgta tgagtgtatg aagggaaatg gaaagcagag aaaagtcgcg 2649 tgccctcccc caggcacctg atctgcccac agacccttca atggggacat ctctggtccc 2709 aatggtcgta aataaaggct aagcgctgga tttttccatg gccccctgac tcctcaggag 2769 cgcaggcaga ggaggtaaac aggaggccag gttacccatg agatgaccag aagctcatcc 2829 agggccggga ccctggttca tctcgtgaat tcttggcagc ggctccaggc tgggcacatt 2889 agatgctgtc atgtgactgg cctggtggcc acct cttggt tctctggaaa tgtgtccact 2949 ctgtgctcag ggaagaaggc tgccgtcctg acctgtcagc caccaggccc tctctgaact 3009 cctcacttga cccggaggca ttgggagcaa acacaaagct cgcccctggt gtcagtggtg 3069 cagacagagg aaaagcagag ggtccgcaaa atgcaactcc tccgtggtga gactttgaaa 3129 aggtgtagag tggttgcaga caaacagcaa aggagtggaa tggaaaaatc tctcttgctc 3189 cccacaagaa gtccactccc ctacggattc ctcagatgcc actggctggc acagcctttc 3249 ccgcccttgg tgtgggagca gcagaagtcc agcgggggtg ggagaatcat cggggtcagg 3309 tcagtgtctc cctcgtctga agtcaaccac tacttttccc tcaagcctac caaagagcta 3369 aagtctgatc tgtagatgtc tgatggtttg aggagaagaa aagatagtct tttagagaag 3429 tggggagtat ccaacttagg gtcaaaatac actgagatta ggccgggcac agtggctcac 3489 acctgtaatc ccagtgcttt gggaggccga ggcggatgga tcacttgagg cctccaggag 3549 ttcgagacca gcctggccaa catggcgaaa ccccgtctct actaaaatac aaaaaattag 3609 ctggatgtgg tggtgggtgc ctgtaatctc agctactcaa ggaggctgag gcacaagaat 3669 agcttgaacc gggagatgga agatgcagtg agccaagatc acgcccctgc actccagcct 3729 gggcgacaga gactccgtc 3748 <210> 51 <211> 4363 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1126) <400> 51 c aga tcc atg ttc act agc ggc ctt aca gaa agt act caa aaa gaa gtt 49 Arg Ser Met Phe Thr Ser Gly Leu Thr Glu Ser Thr Gln Lys Glu Val 1 5 10 15 cga ata gtt ggt gtt gaa gct gaa tcg atg gat tta gtg ttg aac tat 97 Arg Ile Val Gly Val Glu Ala Glu Ser Met Asp Leu Val Leu Asn Tyr 20 25 30 gcc tac act tcc aga gtt att ctt aca gag gcc aat gtt caa gcc ttg 145 Ala Tyr Thr Ser Arg Val Ile Leu Thr Glu Ala Asn Val Gln Ala Leu 35 40 45 ttc act gca gct agc atc ttc cag att cct tcc atc caa gac caa tgt 193 Phe Thr Ala Ala Serla Ile Phe Gln Ile Pro Ser Ile Gln Asp Gln Cys 50 55 60 gct aag tat atg atc agt cat ttg gac cca cag aat tct att ggg gtc 241 Ala Lys Tyr Met Ile Ser His Leu Asp Pro Gln Asn Ser Ile Gly Val 65 70 75 80 ttt atc ttt gct gat cat tat ggt cat cag gaa ctc gga gat cga tca 289 Phe Ile Phe Ala Asp His Tyr Gly His Gln Glu Leu Gly Asp Arg Ser 85 90 95 aaa gaa tac att cgt aaa aag ttt ctg tgt gtc acc aaa gaa caa gag 337 Lys Glu Tyr Ile Arg Lys Lys Phe Leu Cys Val Thr Lys Glu Gln Glu 100 105 1 10 ttt ctc cag ttg aca aaa gac caa ctg ata agt ata cta gac agt gac 385 Phe Leu Gln Leu Thr Lys Asp Gln Leu Ile Ser Ile Leu Asp Ser Asp 115 120 125 gat tta aat gta gac cga gaa gag cat gc tat gaag att ata agg 433 Asp Leu Asn Val Asp Arg Glu Glu His Val Tyr Glu Ser Ile Ile Arg 130 135 140 tgg ttt gag cat gaa cag aat gaa aga gaa gtg cac ctt cca gaa att 481 Trp Phe Glu His Glu Gln Asn Glu Arg Glu Val His Leu Pro Glu Ile 145 150 155 160 ttt gct aaa tgc ata cgt ttt cct ctg atg gaa gat acc ttt ata gag 529 Phe Ala Lys Cys Ile Arg Phe Pro Leu Met Glu Asp Thrhr Phe Ile Glu 165 170 175 aaa aaa att cca cct cag ttt gca cag gct ata gcc aaa agc tgt gta gaa 577 Lys Ile Pro Pro Gln Phe Ala Gln Ala Ile Ala Lys Ser Cys Val Glu 180 185 190 aag gga cca tcc aac acc aat ggc tgt aca cag agg ctt gga atg act 625 Lys Gly Pro Ser Asn Thr Asn Gly Cys Thr Gln Arg Leu Gly Met Thr 195 200 205 gct tct gaa atg atc ata tgt ttt gat gct gcc cac aaa cac tca gga 673 Ala Ser Glu Met Ile Ile Cys Phe Asp Ala Ala His Lys His Ser G ly 210 215 220 aag aag caa aca gtg cct tgt cta gat ata gtc aca gga agg gtg ttt 721 Lys Lys Gln Thr Val Pro Cys Leu Asp Ile Val Thr Gly Arg Val Phe 225 230 235 240 aaa cta tgc aaa cca cca aat gac ctg aga gaa gtt ggg att ctt gta 769 Lys Leu Cys Lys Pro Pro Asn Asp Leu Arg Glu Val Gly Ile Leu Val 245 250 255 tca cca gat aat gac att tac att gca gga ggg tac agg cca agc agc 817 Ser Pro Asp Asn Asp Ile Tyr Ile Ala Gly Gly Tyr Arg Pro Ser Ser 260 265 270 agt gag gtc tcc atc gac cat aag gca gaa aat gat ttc tgg atg tat 865 Ser Glu Val Ser Ile Asp His Lys Ala Glu Asn Asp Phe Trp Met Tyr 275 280 280 285 gat cat tcc acc aat aga tgg cta tcc aaa cca tcc ttg ctt cga gcc 913 Asp His Ser Thr Asn Arg Trp Leu Ser Lys Pro Ser Leu Leu Arg Ala 290 295 300 aga ata ggc tgc aaa ctt gtc tat tgc tgt ggt aaa atg tat gca atc 961 Arg Ile Gly Cys Lys Leu Val Tyr Cys Cys Gly Lys Met Tyr Ala Ile 305 310 315 320 gga ggt cgt gtt tat gaa ggt gat ggg aga att gtt gga cga ctg ttt 1009 Gly Gly Arg Val Tyr Glu Gly Asp Gly ArgVal Gly Arg Leu Phe 325 330 335 gcg cga tgc cag ttg caa tgg aat ttc ata atg ctg tgg agt aca aag 1057 Ala Arg Cys Gln Leu Gln Trp Asn Phe Ile Met Leu Trp Ser Thr Lys 340 345 350 aga aga tac atg ttt agg gag aat ttt ttc tct tct atg agc ctc 1105 Arg Arg Ser Met Phe Tyr Arg Glu Asn Phe Phe Ser Ser Met Ser Leu 355 360 365 aaa aag act act ggg gtt tct taacccccat gactgtgcct agaatccagg 1156 Lys Lys Thr Thr375 Gly Ser gcttagcagc tgtatacaag gactctatct actacatagc tggaacctgt ggaaatcatc 1216 aacgtatgtt tactgtagaa gcctatgata ttgagctaaa taaatggact cgtaagaaag 1276 actttccatg tgatcagtcc ataaatccat accttaaact ggtacttttc cagaacaaac 1336 tccatttatt tgttcgagct actcaagtga ctgttgaaga acacgtcttc agaaccagca 1396 gaaaaaattc cctttaccaa tatgatgaca ttgctgacca gtggatgaaa gtgtatgaga 1456 ccccagatcg gctctgggac cttggccggc attttgaatg tgctgttgct aaactgtatc 1516 ctcagtgtct tcagaaagta ctctaaatga gtagcaggcc ttagtgcatc actggcatct 1576 cattcttagg aaacttgtct ttgatacaaa agagtgctga cagtatttca gaaagctgag 1636 agagttt tat acatggaaaa tgggtatgct taaagattgc agggtaggga gggattttcc 1696 ttcatccttg tgacatttca tttcagtaag gaaaagataa caaagtgcaa ttatcagcat 1756 ttttttttcc tggcataaaa ttaatcattt cattttataa ttttgtgata aatagtaact 1816 gaggtaccag atgaatcagg acaactatgc actcttataa gagcatttag ggtattattg 1876 ggtaaagacg tctaaacttg tttgatgtga cttttaattt taaatacggg taacaatctg 1936 aggcaatatc actaggactt tagctgtgac ctctctaaca cagagaagca ctaacttaga 1996 tcctcattct taatatttat atgtatctat ttttgtgtac tgttttcaag tgtactgaga 2056 tttaaatgtg ttctattatt agagtagatc gaagaaaaaa ttagtctcag aaagagcttt 2116 tagtctgatt gtttccattt cccatgtaat tttaagttaa gctaaagttt taaagtggca 2176 gttttctgtc gatgactttt tcaagtgcta acactgtctc ttttgtgaaa atctggaaaa 2236 gtgctcatat tcacaggtgg ctggtgctag tctaacttaa ttcatgtgta taactagatg 2296 gatttaaatg gtctgagcct atgcctatct ttcaaattgg tgtggatttc atggccatag 2356 tactttacct gttgaactct tgtgatttca caagattctc tacttatgtg ataggagggt 2416 atggccagtt attcatctaa ctggactcaa tcttagaata gtaggaacat tatacccagt 2476 ttgcactaac at gggccatt tgtagcccaa ccttctcttc catctacctg tccattcatt 2536 attggtacaa ggaaaggtaa cttatttctc ttctgcacag agcataatgt gaagttttat 2596 acctactttt aaaattctgc tttccagaaa caaaattcct gcagtggtct aatttaatgt 2656 ctttaagttt catattacaa ttaaaacctc attttttttt tccatttttg cacttaacag 2716 tgatgaatac ttttacgttg gaatcctcct tctagctgaa ggtgattgaa aaggaaaaga 2776 gtgagtgaac agaaccatag ctttctaggt actaaagcat tttttgcatt taactgatga 2836 aatttctaac aatcatcagt taggaatatt aacatgaagg ataaaccaac ttatttgtat 2896 acctaaggca ggcatttgga tcagtaacat gttttactaa gcctagagta attcgtaaag 2956 ggtataagca taggacagat tttgccctca atcacaatat ttgtattcac ttgaaagcaa 3016 actggcatgg ttcgtatttt aaaaatcttg cacaaattgt aatgtgatac tgtgaaacaa 3076 attgaaaaca ttgcctcttt gcatcacata cctcgttttt cagaaacttt ccaaactgct 3136 ttacatagac ctctacaagt agggaatgtt ttctgaagca gaagttaaaa tggacagcat 3196 ttctagaatt aacattttaa aatctagtct tagctagata tgtggtttct tcttattggt 3256 gttgatagta tgtctgtaat ctctgtataa actttgtcaa catttttacc tccccagttt 3316 tatcttctgt tttgtttt tg tttttatcat catgatgttt tggagttatt actgtgtatt 3376 ttagaaatca ttctttacag ttttgcattg ctgaggagag agaaaaaaca atttttttgc 3436 aagagatgtt catgtaattt atttttgaaa gctttgttga ataagatttc ctgccgcttt 3496 ttgacaatct tgtgtattta gaaaaatgta ttacttgaaa acatgacata gaacattgag 3556 ttagcaattt acatgggctg tatgttatat aagagaatga catactgtgg ctaattcaac 3616 agtagattta ttcttttagc ctgcacaaca gttgatcttt tggctatgac aatttgtatg 3676 gagggtacga tctaagttaa gtgtgtcaaa agcaaggctt aggatttgtt atgggagtag 3736 aatatatatt gaattttgta tgaagaacta tttgtttaaa ttatatagct gggatatttt 3796 cccactgtta aaatggattc agaagaggtc ctagaaaagt aagattagtg acatgtgtgg 3856 gtttatattt agatatttaa ggtgcatttt catagtgtgg taagacctta agtaaaaggc 3916 acaatgggta ctacagaatt aaaatgtagg tctaacataa tgccagttcc actttaactt 3976 tgtttttgca tttgaagaat gtatgtagca ctttcctata tatttgtcac acattgaaaa 4036 ctggactggg tataactatg ttataggaaa gtagaaattg tattctttat tttccatctt 4096 tgttttctgt tctacaaagt tgatgcttaa gcatcaagct gattttattg gtcatgagaa 4156 caaatggatg tgatcatgaa gg aatcagat tccctatgta aagcagttta aaatggaatt 4216 caatgttcag tgctcaggta tgtagtaagt actgtagtcc tgtgggggca aatgtgtaga 4276 tatttttaaa cattttgcca taattgcaca attttttgca tttttacctg atgtcatttta ttctttttt 336t <210> 53 <211> 2576 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1062) <400> 53 cgc aca gtg ttg ctg aga ata cga gaa cag tgg aaa cag aac aag aac 48 Arg Thr Val Leu Leu Arg Ile Arg Glu Gln Trp Lys Gln Asn Lys Asn 1 5 10 15 acc ctg cta gaa aat agc cag cgt gtc acc act gcc ctg ctg gcc cga 96 Thr Leu Leu Glu Asn Ser Gln Arg Val Thr Thr Ala Leu Leu Ala Arg 20 25 30 tca gag atc agc gtg ggt gac cgc cag ctg ccg ccc tct gcc gcc acc 144 Ser Glu Ile Ser Val Gly Asp Arg Gln Leu Pro Pro Ser Ala Ala Thr 35 40 45 gtg aac aat cgc tgc ttc cag cag ctg gat gag ggc tat gat gag gaa 192 Val Asn Asn Arg Cys Phe Gln Gln Leu Asp Glu Gly Tyr Asp Glu Glu 50 55 60 tac ggt ggc ttc gct gag gcc ccc aag ttt ccc acg ccg gtg atc ctg 240 Tyr Gly Gly Phe Ala Glu Ala Pro Lys Phe Pro Thr Pro Val Ile Leu 65 70 75 80 agc ttc ctg ttc tcc tac tgg ctc agc cat cga ctg act gat ggc 288 Ser Phe Leu Phe Ser Tyr Trp Leu Ser His Arg Leu Thr Gln Asp Gly 85 90 95 tct cgg gcc cag cag atg gcc ttg cat acc ctg aaa atg atg gct aac 336 Ser Arg Ala Gln Gln Met Ala Leu His Thr Leu Lys Met Met Ala Asn 100 105 110 ggg ggc atc cgg gac cat gtg ggg cag ggc ttt cac cgc tac tcc aca 384 Gly Gly Ile Arg Asp His Val Gly Gln Gly Phe His Arg Tyr Ser Thr 115 120 125 gac cgc cag tgg cac gtc cct cac ttt gag aag atg ctc tat gac cag 432 Asp Arg Gln Trp His Val Pro His Phe Glu Lys Met Leu Tyr Asp Gln 130 135 140 gca cag ctc gct gtg gcc tat tcg cag gcc ttc cag ctc tct ggt gat 480 Ala Gln Leu Ala Val Ala Tyr Ser Gln Ala Phe Gln Leu Ser Gly Asp 145 150 155 160 gaa ttc tac tct gac gtg gcc aaa ggc atc ctg cag tac gtg gct cgg 528 Glu Phe Tyr Ser Asp Val Ala Lys Gly Ile Leu Gln Tyr Val Ala Arg 165 170 175 agc cgg ag tcc gga ggc ttc tat agc gca gaa gat gca gac 576 Ser Leu Ser His Arg Ser Gly Gly Phe Tyr Ser Ala Glu Asp Ala Asp 180 185 190 tcg ccc cca gag cgg ggc cag cgg ccc aaa gag ggc gcc tac tat gtg 624 Pro Glu Arg Gly Gln Arg Pro Lys Glu Gly Ala Tyr Tyr Val 195 200 205 tgg acg gtc aaa gag gtt cag cag ctc ctc ccg gag cct gtg ttg ggt 672 Trp Thr Val Lys Glu Val Gln Gln Leu Leu Pro Glu Pro Val Leu Gl y 210 215 220 gcc acc gag ccg ctg acc tca ggc cag ctc ctc atg aag cac tac ggc 720 Ala Thr Glu Pro Leu Thr Ser Gly Gln Leu Leu Met Lys His Tyr Gly 225 230 235 240 ctc aca gag gct ggt aac atc agc ccc agt cag gac ccc aag ggg gag 768 Leu Thr Glu Ala Gly Asn Ile Ser Pro Ser Gln Asp Pro Lys Gly Glu 245 250 255 ctg cag ggc cag aat gtg ctg acc gtc cgg tac tcg ctg gag ctg act 816 Leu Gln Gly Gln Val Leu Thr Val Arg Tyr Ser Leu Glu Leu Thr 260 265 270 gct gcc cgc ttt ggc ttg gat gtg gag gcc gtg cgg acc ttg ctc aat 864 Ala Ala Arg Phe Gly Leu Asp Val Glu Ala Val Arg Thr Leu Leu Asn 275 280 tca ggg ctg gag aag ctc ttc cag gcc cgg aag cat cgg ccc aag ccg 912 Ser Gly Leu Glu Lys Leu Phe Gln Ala Arg Lys His Arg Pro Lys Pro 290 295 300 cac ctg gac agc aag atg ctg gct gcc tgg aat ggt ggg cac 960 His Leu Asp Ser Lys Met Leu Ala Ala Trp Asn Gly Gly Ala Ala His 305 310 315 320 ctg aga ccg agc ctg tct gta gga tcc ccc ttc aca aag ccc ctg tct 1008 Leu Arg Pro Ser Leu Ser Val Gly Ser Pro Phe T hr Lys Pro Leu Ser 325 330 335 ttc cgg cag cgg cta aat gct cac tct ccc ttg att agc gtt att att 1056 Phe Arg Gln Arg Leu Asn Ala His Ser Pro Leu Ile Ser Val Ile Ile 340 345 350 ctc agt tgacaaaag ggccaagag g gtcacgcgca 1112 Leu Ser agggctggga accccgccat gtctggcttt ggagcccaag atcttaggga tcacccatgg 1172 ctccagggag gtgttggggc ctaaggtgat agggtggaca tgcctggagg gtcctggcca 1232 gcttcttacc actacttgtc tctcctggct ccaggcttga tggtgtcagg ctatgctgtg 1292 actggggctg tcctgggcca agacaggctg atcaactatg ccaccaatgg tgccaagttc 1352 ctgaagcggc acatgtttga tgtggccagt ggccgcctga tgcggacctg ctacaccggc 1412 cctgggggga ctgtggagca caggttgggg gctgggtaga ccgggagggc ccgtctcccc 1472 aacgcgtccc cagcctacct ctgccctact tctcccctcc atgtggactc cagtcctggc 1532 tctgccaggt gcttgctgtg agtttgtagc ttccctgggc ccatttactc atctgggaag 1592 tgggctgatg gcacctgccc aagagggttc atctggaggg ttaagtgaac aaatgcgtga 1652 aagggcctcc tctgggaaag gccctctctc ctggggctct ccccagcccc tcccgtaatg 1712 cctgtccccc agcaacccac cctgctgggg cttcc tggag gactacgcct tcgtggtgcg 1772 gggcctgctg gacctgtatg aggcctcaca ggagagtgcg tggctcgagt gggctctgcg 1832 gctgcaggac acacaggaca ggctcttttg ggactcccag ggtggcggct acttctgcag 1892 tgaggctgag ctgggggctg gcctgcccct gcgtctgaag gacgaccagg atggagcaga 1952 gcccagcgcc aattccgtgt cagcccacaa cctgctccgg ctgcatggct tcacgggcca 2012 caaggactgg atggacaagt gtgtgtgcct attgaccgcc ttttccgagc gcatgcgtcg 2072 tgtcccggtg gcgttgcccg agatggtccg cgccctctca gcccagcagc agaccctcaa 2132 gcagatcgtg atctgtggag accgtcaggc caaggacacc aaggccctgg tgcagtgcgt 2192 ccactctgtc tacattccta acaaggtgct gattctggct gatggggacc cctcgagctt 2252 cctgtcccgc cagctgcctt tcctgagtac cctccgacgg ttggaagacc aggccactgc 2312 atatgtgtgt gagaatcaag cctgctcagt gcccatcact gatccctgcg aattacgaaa 2372 actactacat ccatgactgc cccaaccccc ttggggtggg gcagaaggtg aagcatccca 2432 actgactaga gactcaggcc ctgcagggcc ctatagaacc tgtggccatc cctgagcacc 2492 ctgccaccag gtgacctcgg ccatactcac tgcccccctt gggcacccac tcaccctaga 2552 ataaacttaa cagtgtcccg tggt 2576 <210> 54 <211> 2576 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2146) <400> 54 g atc gtg aac cgg gag aag ctg tcg gag tcg gtg ctg atg aag gtg gag 49 Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 1 5 10 15 cgg gag atc gcc atc ctg aag ctc atc gaa cac cca cat gtc ctc aag 97 Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 20 25 30 ctc cac gac gtc tac gag aac aag aaa tat ttg tac ctg gtt ctg gag 145 Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 35 40 45 cac gtc tcg ggg ggt gag cta ttc gac tac ctg gta aag aag ggg aga 193 His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 50 55 60 ctg acg ccc aag gag gcc cga aag ttc ttc cgc cag att gtg tct gcg 241 Leu Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala 65 70 75 80 ctg gac ttc tgc cac agc tac tcc atc gc cc cta aag ccc 289 Leu Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro 85 90 95 gag aac ctg ctt ttg gat gag aaa aac aac atc cgc att gca gac ttc 337 Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 100 105 1 10 ggc atg gcg tcc ctg cag gtg ggg gac agc ctc ctg gag acc agc tgc 385 Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys 115 120 125 ggg tcc ccc cat tat gcg tgt cca gag gtg att ag gaa aaa tat 433 Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr 130 135 140 gat ggc cgc cgg gca gac atg tgg agc tgt gga gtc atc ctc ttc gcc 481 Asp Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala 145 150 155 160 ctg ctc gtg ggg gct ctg ccc ttt gat gac gac aac ctc cgc cag ctg 529 Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 165 170 a175 ctg g aaa cgg ggc gtc ttc cac atg ccc cac ttc att cct 577 Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 180 185 190 cca gat tgc cag agc ctc ctg agg gga atg atc gaa gtg gag ccc ga Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu 195 200 205 aaa agg ctc agt ctg gag caa att cag aaa cat cct tgg tac cta ggc 673 Lys Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu G ly 210 215 220 ggg aaa cac gag cca gac ccg tgc ctg gag cca gcc cct ggc cgc cgg 721 Gly Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg 225 230 235 240 gta gcc atg cgg agc ctg cca tcc ac gga gag ctg gac ccc gac gtc 769 Val Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val 245 250 255 cta gag agc atg gca tca ctg ggc tgc ttc agg gac cgc gag agg ctg 817 Leu Glu Ser Met Ala Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu 260 265 270 cat cgc gag ctg cgc agt gag gag gag aac caa gaa aag atg ata tat 865 His Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr 275 280 280 ctg ctt ttg gat cgg aag gag cgg tat ccc agc tgt gag gac cag 913 Tyr Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln 290 295 300 gac ctg cct ccc cgg aat gat gtt gac ccc cgt cgg ag gat 961 Asp Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp 305 310 315 320 tct ccc atg ctg agc cgt cac ggg aag cgg cga cca gag cgg aag tcc 1009 Ser Pro Met Leu Ser Arg His Gly Lys Arg ArgPro Glu Arg Lys Ser 325 330 335 atg gaa gtc ctg agc atc acc gat gcc ggg ggt ggt ggc tcc cct gta 1057 Met Glu Val Leu Ser Ile Thr Asp Ala Gly Gly Gly Gly Ser Pro Val 340 345 350 ccc acc cga cgg gcc ttg gag atg gcc cag cac agc cag aga tcc cgt 1105 Pro Thr Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg 355 360 365 agc gtc agt gga gcc tcc acg ggt ctg tcc tcc agc cct cta agc agc 1153 Ser Val Ser Gly Ala Ser Thr Gly Leu Ser Ser Ser Pro Leu Ser Ser 370 375 380 cca agg agt ccg gtc ttt tcc ttt tca ccg gag ccg ggg gct gga gat 1201 Pro Arg Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp 385 390 395 400 gag gct cga ggc ggg ggc tcc ccg act tcc aaa acg cag acg ctg cct 1249 Glu Ala Arg Gly Gly Gly Ser Pro Thr Ser Lys Thr Gln Thr Leu Pro 405 410 415 tct cgg ggc ccc agg ggt ggg ggc gcc ggg gag cag ccc ccg ccc ccc 1297 Ser Arg Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro 420 425 430 agt gcc cgc tcc aca ccc ctg ccc ggc ccc cca ggc tcc ccg cgc tcc 1345 Ser Ala Arg Ser Thr Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser 435 440 445 tct ggc ggg acc ccc ttg cac tcg cct ctg cac acg ccc cgg gcc agt 1393 Ser Gly Gly Thr Pro Leu His Ser Pro Leu His Thr Pro Arg Ala Ser 450 455 460 ccc acc ggg acc ccg ggg aca aca cca ccc ccc agc ccc ggc ggt ggc 1441 Pro Thr Gly Thr Pro Gly Thr Thr Pro Pro Pro Ser Pro Gly Gly Gly 465 470 475 480 gtc ggg gga gcc gcc tgg agg agt cgt ctc aac tcc atc cgc aac agc 1489 Val Gly Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser 485 490 495 ttc ctg ggc tcc cct cgc ttt cac cgg cgc aag atg cag gtc cct acc 1537 Phe Leu Gly Ser Pro Arg Phe His Arg Lyg Met Gln Val Pro Thr 500 505 510 gct gag gag atg tcc agc ttg acg cca gag tcc tcc ccg gag ctg gca 1585 Ala Glu Glu Met Ser Ser Leu Thr Pro Glu Ser Ser Pro Glu Leu Ala 515 520 525 aaa cgc tcc tgg ttc ggg aac ttc atc tcc ttg gac aaa gaa gaa caa 1633 Lys Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln 530 535 540 ata ttc ctc gtg cta aag gac aaa cct ctc agc agc atc aaa gca he Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp 545 550 555 560 atc gtc cat gcc ttt ctg tcg atc ccc agc ctg agt cac agt gtg ctg 1729 Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu 565 570 575 tca cag acc agc ttc agg gcc gag tac aag gcc agt ggc ggc ccc tcc 1777 Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser 580 585 590 gtc ttc caa aag ccc gtc cgc gtc cgc gtg gac atc agc tcc tct gag 1825 Val Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu 595 600 605 ggt cca gag ccc tcc ccg cga cgg gac ggc agc gga ggt ggt ggc atc 1873 Gly Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile 610 615 620 tac tcc gtc acc ttc act ctc atc tcg ggt ccc agc cgt cgg ttc aag 1921 Tyr Ser Val Thr Phe Thr Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys 625 630 635 640 cga gtg gtg gag acc atc cag gca cag ctc ctg agc act cat gac cag 1969 Arg Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Gln 645 650 655 ccc tcc gtg cag gcc ctg gca gac gag aag aac ggg gcc cag acc cgg 2017 Pro Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Thr Arg 660 665 670 cct gct ggt gcc cca ccc cga agc ctg cag ccc cca ccc ggc cgc cca 2065 Pro Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro 675 680 685 gac cca gag ctg agc agc tct ccc cgc cga ggc ccc ccc aag gac aag 2113 Asp Pro Glu Leu Ser Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys 690 695 700 aag ctc ctg gcc acc aac ggg acc cct ctg ccc tgaccccacg gggccgggga 2166 Lys Leu Leu Ala Thr Asn Gly Thr Pro Leu Pro 705 710 715 gggaggggac ccccctccac cccccttccg tgccccccaa ctgtgaatct gtaaataagg 2226 cccaaggaac atgtcgggag gggggtggac acaaaaaccg gccttgccct gcagggatgg 2286 ggctccacag gccgtgccca actgggggtg gttctagggg aacagggggc gggggagctg 2346 tttctatttt atttattgat taatttatta ttttatttat tgatcaatct ctctgcgggg 2406 tggggtgggg gagggacggg agctggttgg ggtggcttag cagatccgga cagggccctc 2466 tgtccctgtg tcgtccccaa ccccctcttc ccgggcccct cctcccctgg tcctcccccc 2526 acgaccttct gtacggattg gctctcgg gtt <210> 55 <211> 5263 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3142) .. (3459) <400> 55 gccaccccag cagggtggat gttcagggac acagctctga gcgagacctg caggccgaga 60 cacacgagaa ccttcaaagc ataggttttt atacgagtga caccccggcc gacctacttg 120 aacggacact tctgtttctg ttctttcgcg ccctgcgcct taaaagggtc gcaaaacatc 180 aaatcagata gggatcttag acttctgttg ctcaagtgca gatgttcccc agataaggaa 240 ataggcccag agaggttaat gatttgccca gagtcacgca ttcttggtcc gccgatgtca 300 agacaaaagc tggcgaacgg gggaggagga gtgaggggat agagtcaccc caggctttct 360 ggagaagtgt gcagttctgg agaagtactt acaattcaac atgagcagga cggagtcccg 420 ctctgtcacg caggctgcca ggctggcgta cagtggcgca atctcagctc gctgcaacct 480 ccacctcctg ggttcaagcg attttcttgc ctctgcctcc tgagtagctg ggattactgg 540 cacacaccac catgcacagt tccttgttca aaatgccaag aacctggatg actcatagtc 600 aagaccctcc accagtaaca tatattggcg agccagccag gagcttggaa ccctcggtgg 660 acagtgccta agcacagagg caaccacagg tttctaacag ggccactctc tggtgaaact 720 gaaaggtttc tgtgtgaaag tgcctgacca ccactgccca gttcagttgc aggaatttag 780 ccaattcaga ggtcttgctc tccataattt ggaattttcc ttcggatttg atcaagttgg 840 atagagttgg t caaacccaa tgggaaaaag atgaaaacaa caagaaacag aaacaaacag 900 caacaacaac aacaacaaaa acaagcagag accgccgtgt gaagatggag gcagagatcg 960 gagagatgct gccacacgcc acaaatgcct ggggctccca gaaactacac ggagcctccc 1020 ccagcggctt cagcaggagc atggctcggc caacactttg atcttggtct tccagcctcc 1080 agaacggtga gtcggtgagt ttctgtggtt taggcccccc agttgtggtt gtttcttacg 1140 gcagccccaa gaaaccaata cactcccccg tccactttcc acggcagagt ttgggcgtca 1200 ctgaatccca cctccacagc aggttttgct tggactgcac agtatttatt gatgctgctg 1260 ttggttttaa tttctaatgt gtgtgcctgt agctgtacca ctcctcctga tgactcacct 1320 ggctcctgcg ggcatctgag atgtggtttc tgctccacac ttcctggggg agcagaggaa 1380 ctcctcagcc tcctctcaaa cttctctcag gttgtgctgt tcactccctc cccaggcttc 1440 cggtccacac ggacagctct gaccccgaga agattctttg tcttagacaa acatctgcct 1500 ccctgtaact tcggttcacc gatacttgct ctgcactcca gggccataca gaacccctct 1560 gctattggct cctaggagac actagcttgt ccggccgtcg ctttaaactg tctagttcca 1620 actccctcag aacttcctca gtgatgcagt ttcctgacgg tcatattgcc tggataagct 1680 ccagtatgtt caactccct c tgtggttcag caaccaggac taaacaggat tcacctgatg 1740 cacattctaa ccagagtcaa gagggcagaa gcatcgcctc ctgcgttcca agctcaatat 1800 ctcaattgta atccccacgt gtcaagggag gggcttggtg ggaggtgatt ggatcttggg 1860 ggcagtttgc cccatgctgt tctcataata gtgaggggtt tctcacgaga tctgatggtt 1920 ttataagggg ctctttcccc tttgtgcacc ctctctcttt cctgcttcct tgtgaagaag 1980 gtacttgctt ctctttctcc tgccaaagca tgaccttata attgtaagtt tccggaggcc 2040 tccccagcca tgcggaactg tgagtcaatg aaacctcttt cttttataaa tgacccagtc 2100 ttgggtattt ctttatagca gtgtgaaaat ggactaacac agatatttgg caggcatcca 2160 gtagtcttcg ataaacacaa ccaccatcta gtggccagaa cagccttatc ggaccccact 2220 gtctgcaatg aaaagctgtt cctttcctca tcctttacag ggccaagcac ccagcatcct 2280 gggacagtgg ccccgtgtgc ccagctttga ggatgagctc atgcctggtt gctctgggtg 2340 gagagaggga agagttgaat caacatccat atgtataaat ctccttttgt gcatttagaa 2400 tcacgtcctt agaataaatt gcgatcagtg gcattactga agcaaattgt atcaaaaatg 2460 caaaaaagac ccatttttcc aaattgtttt ctaacaagga agtcatattg tttgcttttt 2520 gatactgttc tttagaaaac gat gcatgag agttttacat ttcctatagt gtgttctatt 2580 tattttatac tttgcaattt ctgtaatttt taagcactgt tcttcccata ctagaggctc 2640 tgctctaact attcaactct tgtttgtcct agttttccta aaattccctt ttccactggt 2700 gtgtggtgca agatgaggca cattttccat ggatggtgaa cagagggagg agccttttga 2760 tcacaaccag gtcaccccac ttctaagcca ctgtgcctcc agccccacaa gactaaggag 2820 agagagcgca gcgtggtgga gagtgagctg tgctgggacc attgtttccg taacctcgtt 2880 ttctgtgtcc agctgacaca ccttcaaagt ggcatcaggt cctaaactgt agcttgcaat 2940 gtgcctgttt ccagaaacca aggtgaaagt gctttagagt cccttcccag cttttttctg 3000 gaaatgcatg tttctctgaa ctctgagtcc caagaaaaat cacttgagac accaagaaaa 3060 tgggggaagt gctaaaattg tgtgggaatt caagcttaac aataaacatc aagacatttt 3120 tgataaaaat gaatccactg a cat cgg gga gga gca aga gaa cag cac gct 3171 His Arg Gly Gly Ala Arg Glu Gln His Ala 1 5 10 gac act ggg tca gag gct aag acc gac att tct ggg aac cac tcc cgg 3219 Asp Thr Gly Ser Glu Ala Lys Thr Asp Ile Ser Gly Asn His Ser Arg 15 20 25 aag ggc aca gag gag acg ctt tca gcc tct cat cag cca gcc t gg cct 3267 Lys Gly Thr Glu Glu Thr Leu Ser Ala Ser His Gln Pro Ala Trp Pro 30 35 40 gta gct gct gca cgt tat gag tgt gtt cct ggc atg act gct tct aac 3315 Val Ala Ala Ala Arg Tyr Glu Cys Val Pro Gly Met Thr Ala Ser Asn 45 50 55 agg acc aga tct gaa cag tct gga gag agg agc tgt ggt ggc agc aga 3363 Arg Thr Arg Ser Glu Gln Ser Gly Glu Arg Ser Cys Gly Gly Ser Arg 60 65 70 cag atc tct gct tca ggg gcc agg tgt cta gaa gaa atg ctg agg cag 3411 Gln Ile Ser Ala Ser Gly Ala Arg Cys Leu Glu Glu Met Leu Arg Gln 75 80 85 90 tgt cac gct ggt gtc tgt cct cct tac aga atg cct gaa cag ttc cat 3459 Cys Ala Gly Val Cys Pro Pro Tyr Arg Met Pro Glu Gln Phe His 95 100 105 tgactcaaag tgaagatcaa aagaaccaaa tgacagcaat agccaagtgt aatcatcagt 3519 aaccctgtgt tctatccaca gttaaaagaa tattggcaga gaaacagcct tggtgttcca 3579 gcaggagtga agaggaacag gaaaacgagt ggcagtagcc ctgaaacagc cacttctggt 3639 ggttgccact cacctgagga tctgacgttg gacatctcac ctctgtgagc tcaggaggct 3699 cacaatctcc tgagctttgg tctcctcaat tgtaaaagaa gccagctgac ttt tcacttg 3759 aacactcaag cactctctgg ggaggtgccg ggcagtgagg gactgaggcc tcctgccaac 3819 agccatagat ggagtctcgt tctgtcaccc aggctggagt gcagtggcgc agtctcggct 3879 cgctgcaagc tctgcctccc ggattcccgc cattctcctg cctcagcctc cctagtagct 3939 gggactacag gcgcccccca ccatgcccgg ctaatttttg atatttttgg tagagacggg 3999 gtttcgctgt gttggccagg atggtctcga tctcctgacc tcgtgatcca cctgcctcgg 4059 cctcccaaag tgctgggatt acatgtgtga gccaccacac ccggccccat ttttaatacg 4119 ttttttaaag atgcatataa aatgcattac cctctggaag attccagtaa cttactgaag 4179 caagtttctc ctctacatat acctatttct gccatgagta actgttcatt ttcagtgagt 4239 catttgagtt tctgttattc aggtatacag agttcctgtt gtctttttag tcaacaaagt 4299 ttaacaaaga ccataataaa gatggctttc agcagctctg ttattgggaa gggttgtatt 4359 catgtgaaga aagaaattat tttattttat ttttaagttt tagtagaggg ggggttttgc 4419 tatgttggtt aggctggtct cgaactccca tcctcaagtg atccacctgc ctcggtctct 4479 caaagtgctg ggattacggg catgagccac tgtgcctgga cagtaataat attttttaaa 4539 aggctgacat cagcagatca gctattctgg aaagattttt aaacactcag aggttttt tt 4599 gtgtttgttt gttttctttt cttttctttt ttggaggcag ggtcttgctc tgtcgcccag 4659 gctaaggtgg agtggtgcaa tcatggctca ctgcagcctc gaactcctgg gctcaaacaa 4719 tcctcacacc tttcatacct taggcccctg agtagctggg tgggactaca ggcatgcatc 4779 accatgcttg gctaattttt aattttgtat aggtggggtc ttgccgtttg cccaggctgg 4839 tgtcaaactc ctcaagtaat ccttctgcct cggcctccta gggtgccggg attataggcc 4899 tgagccacta cacacagccc ggagttttta aaaaatactc aattaaaatg cttcatttaa 4959 gtgtatgtct aagaaaattt aataattgat taaatattgt tgaatagact gaaagcacaa 5019 catccaagca catgaattaa gcaaataatg caagcatagc tcccacactc cacaaatgtt 5079 ttctagtcat tccaaagcca ttctttttag aggatcttta agaaaatgct tggctctcat 5139 ccgattatta tacaagagat taagaattta ctgatcagtag atgatc aggtcagattag attag atgatc agatcagtag attag atgatc agatcagttag agg <210> 56 <211> 4018 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (207) .. (884) <400> 56 gcggccgcac agactcaaag ccccgcgggc gagctcagca gcccggagcg accgcggccc 60 cgccgcctcc cccgcgagtc ccggcgatgc ggcccggcct gtgagcggcc ggcgaccctg 120 ggacgccccg ccgcacaact acctcaacgc cgtgccgccc ccctcccgcc cccaggtttt 180 tgcactgcca tagggcgccc ccgtga ggc gct tcg ccc ccc acc atg ttc cag 233 Gly Ala Ser Pro Pro Thr Met Phe Gln 1 5 cgc ctc tcc agc ctc ttc ttc agc acc ccc tcg ccc ccc gaa gac ccc 281 Arg Leu Ser Ser Leu Phe Phe Ser Thr Pro Ser Pro Pro Glu Asp Pro 10 15 20 25 gac tgc ccc cgc gcc ttc gtg tcg gag gag gat gaa gt ggc tgg 329 Asp Cys Pro Arg Ala Phe Val Ser Glu Glu Asp Glu Val Asp Gly Trp 30 35 40 ctc atc att gac ctg ccg gac agc tac gcg gct cca ccc agc ccc ggg 377 Leu Ile Ile Asp Leu Pro Asp Ser Tyr Ala Ala Pro Pro Ser Pro Gly 45 50 55 gcc gcc cct gcc ccc gcg ggc cgc cct ccg ccc gcg ccc tcc ttg atg 425 Ala Ala Pro Ala Pro Ala Gly Arg Pro Pro Pro Ala Pro Ser Leu Met 60 65 70 gac gag agc tgg ttt gtt acc cct ccc gcc tgt ttt acg gca gag ggg 473 Asp Glu Ser Trp Phe Val Thr Pro Pro Al a Cys Phe Thr Ala Glu Gly 75 80 85 cct gga ctc ggt ccc gcc cgc ctc cag agc agt ccc ctg gag gac ctc 521 Pro Gly Leu Gly Pro Ala Arg Leu Gln Ser Ser Pro Leu Glu Asp Leu 90 95 100 105 ctc atc gag cac ccc agc atg tcc gtt tac gtc acc ggc agc acc ata 569 Leu Ile Glu His Pro Ser Met Ser Val Tyr Val Thr Gly Ser Thr Ile 110 115 120 gtg cta gag ccc ggg tcc cct tcc ccg ctc ccg gac gcg gcc ctg cct 617 Val Leu Glu Pro Gly Ser Pro Ser Pro Leu Pro Asp Ala Ala Leu Pro 125 130 135 gac ggc gac ctc agc gaa ggg gaa ttg acg ccc gcc cgc cgc gag ccg 665 Asp Gly Asp Leu Ser Glu Gly Glu Leu Thr Pro Ala Arg Arg Glu Pro 140 145 150 cgg gcc gcg cgc cac gcc gct cct ctc cca gcg cgg gcg gcg ctg ctg 713 Arg Ala Ala Ala Arg His Ala Ala Pro Leu Pro Ala Arg Ala Ala Leu Leu 155 160 165 gag aag gc g ggc cag gt cag cgg gcc cgg cag cgg gca 761 Glu Lys Ala Gly Gln Val Arg Arg Leu Gln Arg Ala Arg Gln Arg Ala 170 175 180 185 gag cgc cac gcg ctg agc gcc aag gcg gtg cag cgg cag aac cga gcc Aula Glu Arg Ser Ala Lys Ala Val Gln Arg Gln Asn Arg Ala 190 195 200 cgc gag agc cgt ccg cgc cgg tcc aag aac cag agc agc ttc atc tac 857 Arg Glu Ser Arg Pro Arg Arg Ser Lys Asn Gln Ser Ser Phe Ile Tyr 205 210 215 cag cc tgc cag cgc cag ttc aac tac tgagcgtcca ccggccgcgc 904 Gln Pro Cys Gln Arg Gln Phe Asn Tyr 220 225 cacgaacccc ttgccgatcc cgatccctgt cgggctcctc cgactcctcg ggctggacac 964 cgaaacctcc cttcttaaag cgtgtgaggt tgggtgatag ccgttccttc cccgacaccc 1024 tcaatttccc catctctgat cctctaatct gcctctgaac ccattcaccc ttcaccctca 1084 ctcctggtcc ccatacccag catctaatca tccatgcccc ctactcctgg cccctccatc 1144 ctttcttctc tggtccccat ccctgtctct ccctttcacc cttgccctcc agtcctctac 1204 ctctggcctg cccctatttc tgaaagcttc ttccagtccc tgatctggct cattccccac 1264 cttcaactcc caccttacat gtctcacact atcccatggt tggcattaca ctcactcctg 1324 ttcccttatt cttcattccc agtaattccc taccaaatgg tggggaccct gagcccagct 1384 ctgaccaggt agagcctgtg cagcctgggc tgctgtcatt gccctccagt aagggctcag 1444 ggttttgctt ttagtctccc cttccttctg ccttgggggc ggtactctgt ggagctgc tt 1504 aggcctggaa aggtacagta tgtagaagag gactgtgaga cgtgagttag agggagaaga 1564 tggagggaat ctagggaacg aggcagccta ttggagatgc ggacaggaca gacacgttga 1624 gaagctgcag ggagcagggc accaagggag tgtgcactgt gcttgctcag agaggccaaa 1684 ccctgctccc aggctgaagc ctggagtctg cccccacttc ccttttctat aatccaccct 1744 tctgcaggcc ctgaaatctg aagggcttag ttagtacctt gccactctac ccccaacacg 1804 tcacccgagt agaagctggg caaggcccta ccatcctggc cgtctgttca caagcccaag 1864 gtgctagaac tagcttagga gacatgcagg ccacagggct tctaggcagg gaaagggcac 1924 acaccctagg tcagcgtgca gagcagtgat gctggaggac acaccatggg gtgaagccat 1984 cccaaggctg acagctcagt cttcaccttg cctctggcct tgtatttcac accctgctca 2044 gtatggctag ccagcagtcc tgagtaggag tccaggactc ccactgtctc aatctgcaaa 2104 ttgttcctat ccaggttcag ggccttcagg gggcctcttt tcattttctc ccacaggcct 2164 ctctttcttt ctaggttgct ggggagaaat gggtacccta tgatccccct ccccttctcc 2224 tccagtaaat acctggaaga gggaacctga atccctgggg gagacagaag gggcaggggc 2284 caccagcctc cccttcttgt ggtgagactg aattttgggc tcagacacca gcaacagcct 23 44 cttgggatgc cctgagttgc ttcccatttc ctctttctag ccgtcctttt ctagtgtgtg 2404 ctcactcttc ctaggaactt ttaagacttc ttggtaccta tgaacatagg tcctcccctc 2464 accccaactc taggtttcca ggcctcacag ccaagctgaa gcttggagaa aactctgcat 2524 tcccatgagg gcaaaggcag ctgccctccc tgaccctata gccccaggcc tcatgggggg 2584 tatgtgggga agggatgggg tatccccatg gatgctggga tgaggacaga ggaagacctg 2644 atggggtctc ctattccagg gaataagcca aattaacact aaaaacggat caaagctccc 2704 acgccagtcc actagggccc cagtagttga cagccttgct cctctcccaa gttctccttc 2764 agaacctagt tgcttttatt cttccagcta ccacttgggc acttcacagc cagcctaggg 2824 tcttcggcac ctccaagagc tgaatctccc tccaaccctt cttgcctact cctcactgcc 2884 agctgggacc taggctcagt cctgtgtggt gcccatgatc cttctggtgg gggaagagtt 2944 taagttatag ggcatttggc tcaaatttta aaaggccttt tgtttaccta tatttctgga 3004 ggctcctgta ttctagaacc caatctctca cctgcttggt tgcaaggctc atattttttt 3064 gtacctttcc tatagattct gtagcatttg agtgtggcaa tattttaatt gtgtatagat 3124 ttctaagaac caacactact cagtctcctg ctagtctgac tcctgaagca tcagcccttg 3184 tca tactgta ttgactgtgt acgtgccttt caccttgagc atgcttcagg attttttttt 3244 aaaccacaga acttgaatac atgagggaac cagagttcaa agtcctatgc aaccttagga 3304 gggggttaga gagtctgttt tgattgatgt tttctgaggc cctagaggag tttgtatcaa 3364 tttgtgagta ttaatgtcag tactaccagc actttgccaa aactgtcaga gggacccgtt 3424 tctagagtga gtcccagtta catcaaacag tgacttccag ttattcccca gtaagtctga 3484 gtggttcctt caagctgggt gtctttccag cctttgccag tctagcccca gcagggcacc 3544 gtgtatgaat gcagtttggt gctgttttag agtatgcctg ctccccagcc ccctgcctgg 3604 aaccctctga gcaacttgct ctgacctata atgtcttagg tgcaacacgg accccaccag 3664 agctcttgga taccccccta gatccatgtg gctttatgtg aggggactga atgcagacac 3724 accatagccc ccttctacta ctttccctct cgccctgcca cctagttcca catggaacca 3784 acaagttgag tgcatccctg ttgggtgttt tgtgttgaga ctggctgaaa tgaggagact 3844 ttgaccatgt gacgtgtcaa cagactcaag gagacaacca cctcaactgg gtcatgtggc 3904 atgcctgtgt atgtgtgtaa cagaattctg attgttagac tgtaatgcta ttcctctatg 3964 ggagaaaaaa attaatataa agaaaaacaa ataaaaatat atttaaagca catg 4018 <210> 57 <211> 4891 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (317) <400> 57 tt tgg aaa ggg att gaa ttg gaa att gtc aat agc tgt gaa aag aac 47 Trp Lys Gly Ile Glu Leu Glu Ile Val Asn Ser Cys Glu Lys Asn 1 5 10 15 aat agt gtt tgt tcc cat cac cgt gaa cat gaa att ggt gct ccc cgt 95 Asn Ser Val Cys Ser His His Arg Glu His Glu Ile Gly Ala Pro Arg 20 25 30 tgt tcc tgt aac cat gga cac cag ctt gat tct gat gag aaa aca tgc 143 Cys Ser Cys Asn His Gly His Gln Leu Asp Ser Asp Glu Lys Thr Cys 35 40 45 ata gat ctt gac gaa tgt gag aat gga gaa gcc tgc tgt gcc cag ctc 191 Ile Asp Leu Asp Glu Cys Glu Asn Gly Glu Ala Cys Cys Ala Gln Leu 50 55 60 tgc atc aac tat tta gga ggc tac aaa tgc aga tgt cag gaa ggc ttt 239 Cys Ile Asn Tyr Leu Gly Gly Tyr Lys Cys Arg Cys Gln Glu Gly Phe 65 70 75 cag atc act tcc aat ggt tgt gaa tgt gat gat gtg gat g 287 Gln Ile Thr Ser Asn Gly Cys Glu Cys Asp Asp Val Asp Glu Cys Leu 80 85 90 95 gat gtc agt ata gtc tgt gac caa cta cat taattctgtg ggaacatacg 337 Asp Val Ser Ile Val Cys Asp Gln Leu His 100 105 aatgtagtc tgaaga gaaatgacag aaaaacttac ccctctttag 397 atgatgatga gctagaggaa gaagaagagg aatgagaagt tgtgaggttt ccaggtcttc 457 tattcaagag cccacctcaa cagcttcatt atgttgctac ttttctgcct cccacctaca 517 aagatgaaga agatgaggag gaagaggaaa aagatattca tagagaactg actgctttgc 577 acaattttgt ctgtttagat cacatctttg gacacaattg cagcttgagc tgcaaggact 637 gcatgaatgg aggaaagtgc caggaaggaa agagtgaatg ctcctgccca gcaggttgcc 697 gtgtcattct ttgtaatgaa agtaagtgac accctgagaa ttgggtaagt gctccaaact 757 actcctttac atatgttctc cccaaaatgt tttaataaag taagcaattg ataagtatga 817 gaagacaatt tatttgttgg gcataaataa tgcttatgaa gtgctttaag ttttaaactg 877 aatatgtgat ttaaaaagga gattttgtgt tccctaggaa actcaacatg ctgtctcttg 937 tttatccatg gaatgtaaaa gttaataaag gatcctaata ttctaggcct ataaaaatcc 997 ctccatttaa ataaatcatt aggccctgac aagctattcc caatgaagaa aaaaggaaag 1057 gatttgtgct acaaagtgca atttaaatgg acttgcttga ctgtttgcta cttggttttg 1117 tgtacttttt tgttcttttt ctttttaaaa acatgtaaac acagccaatg acactggttt 1177 aattttttta ttcaagtctc tcatgagtaa gttcaaagat ttaaaa atga tactgcccaa 1237 aattcctttc ctctatattt taaatgaagg tatgctttca ggagttcaaa cttccaagtg 1297 ataaaatgta ttgactatct ttgtttcttc tttctctttt taaattcatt ttatgagttc 1357 tatttatata agtgttttgt cttagttttt gtgattggct tggaagatga tatgaacaga 1417 ttttcttttg aactctctac atatgggagg aacacagctg ttgttactct tatatgatat 1477 agatgcaaaa cttcagtcat aacatagtga aatggtttaa ccaagattac tagttagggt 1537 tttgaggatc ttcctcatgc atccctctga tcatgtttct ctgctgctga aaagctttgt 1597 gcctttccct tcacataaag tgtatacatc ttacccagtc actagtggcc atcagactct 1657 cataaatcct tttggctttt tgtcctagtc ttaacgcttc acctaaccta ttatttcccg 1717 catactaaac cactcactac ttaatgtgct gcatttttca tctttgtgcc ttttgctaaa 1777 ctgtcatcct tgaaggccta tttctgccta ttgcatgaag ctttatttga tggcctcagt 1837 ctaacacagc tatttatgtt tttggtggat taaaaaaaaa ttctctctct ctacattgga 1897 ttattttcta tcttctttac tagactggga gcttgctggc caggtcctat tcatgcttat 1957 tcattgtgaa tttctccaca ctggaggtat ccagtgcatg aatgaacaca tgaataaaac 2017 ttggtgttga aactcccagc tatattgacc tgcaacttgg cacactcaaa t acataaaat 2077 tgggatcaaa taaatattat tgcatgacca ctagtaagtc aatatttacc ttatattgta 2137 agttttattg ataaatatgc atctcccaat acttatccct aacatagtaa aaaaactaaa 2197 aaatctatct caaacaaata agaataaaat aaataaaaat ttaaaaataa aaaataaaaa 2257 tataaaaaat attttacaca ctaataaatt taaaaactaa aaaataaaat aatgaaaaaa 2317 tctgtctcta acacgtaaga ataaaatatc tctgacataa aattaatacc aaaatattga 2377 aaatgagctt gctgataaaa tagaaatgag atggcatctt ctttggcttt agaaaacctt 2437 ggggatctct caaatattta tatgttgcaa taaaggggag tctacccctg aaagcagaac 2497 ttctatcttc tttgtacttt ctctatatcc ttctcttatt tcttttacaa caatgaaaac 2557 agaacaatct atttaggaga aacaaaaaac aattgttcat atttttttaa caaaaagaag 2617 gagtgggaat attttcttta aaatccctat tggccaggga tgctggctca tgcctgtaat 2677 ctcaacactc tgagaggctg aggcaggaag atcgcttgag gccaggagtt tgagaccagc 2737 ctgggcaaca tagcaagtcc tagtctctac aaaaataata ataataagaa gaataagaat 2797 aaatcccttt aaactacaat aagcagagac cagttattca ttggctatat ttttaagatt 2857 gccagctttt caaatgcagc aaaataaatg aaaaaagaac tttcaacagg gatcta gaag 2917 tcagttttcc cgttgagtag atcttctagc ccaatacatt tattagtcta taatgaaaat 2977 atctactttg atttcttaga ggtttcttca aataaatata ttgaaacaat tttaaaatga 3037 ccacatatta tttaatttta aaagcacact tttagaaccc catttcttat gaaaggtttc 3097 atatcgagat catttgttat tgtgagactg tatctggtgg aaaggaaaga taggagtatt 3157 tttcatatgt caaatgagta gactaaaaca tgggaggaga gatttatgac ttttttttta 3217 catcatccag ctatggtttg ggacgtgttt gttttacatt tttcttcccc agaatctcta 3277 cactgtttga tctaatgaag tatttggcaa atctatagac tatatgataa tcacagttta 3337 ctttgtgagg gagtgtcaaa ttatagtgtc ggtttgtcta tattgatgac tcgccataat 3397 ccagacgctg tgcaagccat ttaaacttcc ttagcttcat tttacaggtt aagtgtttaa 3457 aaattgcccc ttctgtagtt gctgttaaaa tgcaaacatt aacaaaatgt aaattaataa 3517 tataggccac aacaaatgct tgttgccagt ctctcatttt ttgtttatcc tttccttttt 3577 tccctttcat agtaacctat ggcttgaaag caaagaaaag ggtgaataag aagccaagtt 3637 ccatattagc atctggaatg ggagcagggg atgaatggag cagattttat aaatgtaatt 3697 ttataacatt tagcctatta tgataaaatg tcaattacaa ttattactga aattatctca 3 757 acagctacat ttgcttacat tacaatataa agtcaccgac atttttccca atttattgtt 3817 ttatagagca ctaaacacaa aaataccaac aacctaatga aaactgttgt ttgcctgact 3877 ttgtcttatc tttggcaatg caaactacct tgggaccccc atgagaacct tagctgcatt 3937 cattcctggt taaaaataca tgacatttta aaagcatttt tccctcagtt ttcaaaatag 3997 aagatgcagt ttgtttctcg ttagggttgg aattgtacag caaagttgtc tgggtagctt 4057 ttaaagtgtg agggttagag tttaagaaat gagataaatt ttgcatttga aacttgttag 4117 caatttcttc agtcatcatt attttaacta gctgtatcag taatcccctc gggagtgatt 4177 atgctataca aactaggaac atgccagaaa attttcctgg gtctgtaagc cactgagttt 4237 ttaattactt ggtatctatc ctgatagaaa gagaagctat tttttccctc catttgtatc 4297 agaacacgta tgttccattg cttgttcatc ttctctagtt tcttcatagc ttattcccca 4357 gagaccagtg agaaagaatg tggcagcatc ggtaattgtc agaatggagg catctgtgat 4417 cttctgactg ggcactgcca gagcccccca ggggttcatg ggaaaacttg tgaagataga 4477 aggaatgtct ggtgccagtc agttaagttc ttggggtttc taatgagaag taaactaagt 4537 gaaagttgca tgtgtatttt tcaaaatggc ctttttctga agaagtaaaa gactgtgaaa 4597 gc tgtgtctg tatatataaa agagtacaat tgttttgact gatgacatgt gtaacaacga 4657 aataagtgat atttaaatct ccaactgtga tctaagcagg acgaatcctc ttacagagaa 4717 agcctttttc ttctactgag caaaaagtta caattatgta tataggttta gatgtaggag 4777 cttaggagaa gttattttct ctgcataaca aaatgaagaa caatagagct ccttggggaa 4837 accagggagg aagacagatg aaaattagag aagaaaaggg aaggaggtag agag 4891 <210> 58 <211> 3983 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (864) <400> 58 gac gag ggt gac ggg gac ccc gcc agc ccc agc atc gcg cgc cgc agc 48 Asp Glu Gly Asp Gly Asp Pro Ala Ser Pro Ser Ile Ala Arg Arg Ser 1 5 10 15 cgc ggc ccc gca gct ccg ccc ccg gcc cgg ccc ggc ccc ggg ccc gct 96 Arg Gly Pro Ala Ala Pro Pro Pro Ala Arg Pro Gly Pro Gly Pro Ala 20 25 30 cgc ccg ccg ccc cgc atg gag ctg tca gcc atc ggc gag cag gtg ttc 144 Arg Pro Pro Pro Arg Met Glu Leu Ser Ala Ile Gly Glu Gln Val Phe 35 40 45 gcc gtg gag agc atc cgg aag aag cgc gtg cgg aag ggt aaa gtc gag 192 Ala Val Glu Ser Ile Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu 50 55 60 tat ctg gtg aag tgg aaa gga tgg ccc cca aag tac agc acg tgg gag 240 Tyr Leu Val Lys Trp Lys Gly Trp Pro Pro Lys Tyr Ser Thr Trp Glu 65 70 75 80 cca gaa gag cac atc ttg gac ccc cgc ctc gtc atg gcc tc gag gag 288 Pro Glu Glu His Ile Leu Asp Pro Arg Leu Val Met Ala Tyr Glu Glu 85 90 95 aag gag gag aga gac cga gca tcg ggg tat agg aag aag aga ggt ccg aaa 336 Lys Glu Glu Arg Asp Arg Ala Ser Gly Tyr Arg Lys Arg Gly Pro Lys 100 105 11 0 ccc aag cgg ctt ctg ctg cag cgg ctg tac agc atg gac ctg cgg agc 384 Pro Lys Arg Leu Leu Leu Gln Arg Leu Tyr Ser Met Asp Leu Arg Ser 115 120 125 tcc cac aag gcc aag ggc aag gag aag ctc tg ctg acg tgc 432 Ser His Lys Ala Lys Gly Lys Glu Lys Leu Cys Phe Ser Leu Thr Cys 130 135 140 cca ctc ggc agc ggg agc cct gag ggg gtg gtc aag gcg ggg gca cct 480 Pro Leu Gly Ser Gly Ser Pro Glu Gly Val Lys Ala Gly Ala Pro 145 150 155 160 gag ctg gtg gac aag ggc ccc ttg gtg ccc acc ctg ccc ttc ccg ctc 528 Glu Leu Val Asp Lys Gly Pro Leu Val Pro Thr Leu Pro Phe Pro Leu 165 170 175 cgc aag cccg aag gcc cac aag tac ctg cgg ctc tcg cgc aag aag 576 Arg Lys Pro Arg Lys Ala His Lys Tyr Leu Arg Leu Ser Arg Lys Lys 180 185 190 ttc ccg ccc cgc ggg ccc aac ctg gag agc cac agc cat cga cgg Pro Pro Arg Gly Pro Asn Leu Glu Ser His Ser His Arg Arg Glu 195 200 205 ctc ttc ctg cag gag cca ccg gcc cca gac gtc ctg cag gcg gct ggc 672 Leu Phe Leu Gln Glu Pro Pro Ala Pro Asp Val Leu Gln Ala Ala Gl y 210 215 220 gag tgg gag cct gct gcg cag ccc cct gaa gag gag gca gat gcc gac 720 Glu Trp Glu Pro Ala Ala Gln Pro Pro Glu Glu Glu Ala Asp Ala Asp 225 230 235 240 ctg gcc gag ggg ccc cct ccc tgg aca cct gcg ctc ccc tca agt gag 768 Leu Ala Glu Gly Pro Pro Pro Trp Thr Pro Ala Leu Pro Ser Ser Glu 245 250 255 gtg acc gtg acc gac atc acc gcc aac tcc atc acc gtc acc ttc cgc 816 Val Thr Val Thr Thr Asp Ile Thr Ala Asn Ser Ile Thr Val Thr Phe Arg 260 265 270 270 gag gcc cag gca gct gag ggc ttc ttc cga gac cgc agt ggg aag ttc 864 Glu Ala Gla Aln Ala Ala Glu Gly Phe Phe Arg Asp Arg Ser Gly Lys Phe 275c acc 285 t tttttactct tcttaaactg ttttcttttg ggcttggggt gggacttcca 924 gagataggga tgggttgggg gcggggtaat tattttttaa aaaaaaatac cgagcagcaa 984 aaggggagaa gatcccacta ctctcccacc acctgccctt tctctgaggg acgtttacca 1044 cgaggcctca ggctggggat ggagagagtt gctctgggag ttggggtacc acccccaggg 1104 caggatgagg acaggatcac ctgcccggga caccaccatt atcattctcc tctagtgacg 1164 cagcagctgg ttctgggagt taaaggagca ttggaaggcc caaaccct ct cccttgagtg 1224 gccaccccag cctggttggc tggttttccc cttttctctt gtttcaattg ggtctttacc 1284 ttgaactctc ctctctggct ttgcggtggg ctgtggaggc tggttttgac caaaagtgag 1344 tggggcggga ggaaggggca ggaggaaggg ttgaggttac ttggggcgag tcccttcccc 1404 ttcagagagg cttctatcct tcccagggag gaggcgccgc tgagaccctt ctgctgagag 1464 ctctgccctc ccctcatcac ctggcctgtg cagaaacgct catgcacacc tggctgcaca 1524 ggtgtgcacg cattaccctt cgcgtgtacg ttcccatgtg ccccgtgaaa gcatgtgtgg 1584 ctgcagacgt gtccacatgg gccttgcgaa cctgggttag aaaccttggc caggcgaacg 1644 tggggtgatt cacagcacaa aagacctcac caccacacct gcactcaccc caccttgcat 1704 gcaccttgct acctgcttgc ggctttcagc ggagggcagg ggtctggcac aggtgcgatg 1764 gcaccccatg ctccaggcat acagatgtgg tttctcggct gcaccgggcc aggctgcggg 1824 tgtgcaggcg tctgctaagt tgtgtgatgt atcagcacag gctttgagac gtctggaccc 1884 tgtccttcct cccgtgaggg gttcttgttc tttctgactc aggtgacttt tcagcccttc 1944 caattcccct ctttttctgc cctcccctcc aactcagcca acccaggtgt gggcagtcag 2004 ggagggaggg agtgtcccac cacgttctca gggcagccct tgactcctaa gcc ccttcct 2064 ccttccattc tgcatcccct ccccatccaa cctaaatgcc acagctgggg ctgagctgta 2124 ttcctgtgga gggacctctg ccgtgcctct ctgaggtcag gctgtgctgt gtgatgggca 2184 ggctttgccc cagcccaccc ctggcaaggt gcacttgttt tctggtttgt acaaggtgtc 2244 ctgggggccc gtcgcttccc tgccagtgag gagtgacttc tccctctctt ccagtcctgt 2304 aggggagaca aaaccagatt ggggggccca aggggagcat ggaaaaggcc ggctcccctg 2364 tctttccttg gctgtcagag tcagggtaac acacaccaag agtggagtgc ggccagcaag 2424 tttgagacct gcccgccctc ctcgcagctc tgctctgtgt cctcaggaag tcacagagtc 2484 tactgaggca aggagagggt gattctttcc ccaaatccct tcttccctgg ttcccaaacc 2544 aaagacagcc tgcagccctt tctgcatggg gtgctctgtt gacaggcttc ccagatccct 2604 gagtctctct ttccttcctc ctcgatcttt agttgtccac ggtcaattca gtgcttccat 2664 tgggggacag tcccctccgg gatgacctga ttcacctcca gcccagggaa tggaatctag 2724 aggaatacgt ggggtgggtc tggacaagga gcggcaggaa tcaccaccca tctccagctg 2784 tggagccctg tggaggggaa ggggaagctt ggggttcaga gggaactctt ccaggagagg 2844 ggtgcccagc ggaggtaaag atgatagagg gttgtggggg gtctctagtt gaatgtttt g 2904 gcccatgact ttggaacatg gctggcagct tccagcagaa gtcacgctcc ccatccccca 2964 ggggacatag gacctttttc ctgcttcctg gtcactttca aagaactatt tgcgcaatct 3024 gtgggtctgt ggattcacgg ggctttctgt gtgggtgctg cagttgcttt tgtctgcagc 3084 agcaggacac atctttcctc ttactcagcc ctttatggcc catggggaac tccgtggctc 3144 agggagagct gaactccagg ggtgtgacct gggacaggtg ggcctgaggt gcccagctca 3204 gggcagccag gtggctcatg ggctgtagtg agccagctcc ctgggggaaa aggctgtggg 3264 ccgttaggac catcctccag gacaggtgac ctctatgagg tcacctacgg ctgtggccgt 3324 gcaggcctcc ttccagccca gagtggccca gtagagcaag gcagacagtg acctccaccc 3384 ccgcagccct cttaaaaggc cagtactctt gggggtgggg ggagggttta gaaagcattt 3444 gcccatctgc ctttctttcc cccagccccc acccgctttg aatgtagaga cccgtgggca 3504 cttttccttt tgtggtgggg ggtgcggagg aggtaccccc acccctggca cagccgcctg 3564 gaatgcagga ctgtcactgc tgttcgggtg atgacctcgt tgccaagctc ctcctgtccc 3624 cttgttctgg gggcaggcgc tgtgcttctg tgaggtggtt tagcttttgc tttcgaagtg 3684 gccagctgcg gccaccaggt ctcagcacaa gagcgcttcc tttgcacaga atgagcttcg 3744 agctttgttc agactaaatg aatgtatctg ggaggggtcg ggggcacgag ttgattccaa 3804 gcacatgcct ttgctgagtg tgtgtgtgct gggagagtca gagtggatgt agagcgcggt 3864 tttatttttg tactgacatt ggtaagagac tgtatagcat ctatttattt agatgattta 3924 tctggtaaat gaggcaaaaa aaattattaa aaatacatta aagatgattt aaaaaaaag 3983 <210> 59 <211> 7164 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (805) .. (1914) <400> 59 gcagcgctga ggcgagaggt tggtgggtgt ctccggccat aatgacccag gctgagaagg 60 gtgatacgga gaacggaaag gagaagggcg gcgagaagga gaaggagcag cgcggcgtga 120 agcggcccat cgtgcccgcg ctggtgccgg agtcgctgca agagcaaatc cagagcaact 180 tcatcattgt catacatcca ggttcaacaa ctttaaggat tggtcgagcc acagacactc 240 ttcctgccag cattcctcac gtcattgccc gaagacacaa acaacaaggg cagcccctat 300 acaaggacag ttggctccta agggagggac taaataaacc agaaagtaat gaacaaagac 360 aaaatggcct taaaatggtg gatcaagcaa tatggtctaa aaagatgtcc aatggtacaa 420 gacgcattcc tgtgtcccct gaacaggcac gctcctacaa taagcagatg cgacctgcaa 480 ttttagatca ctgttcggga aataagtgga caaacacatc tcatcaccct gagtatttag 540 taggagaaga ggccttgtat gttaatccac tggactgtta caatattcac tggcctatca 600 gaagaggtca gttaaatatt cacccaggcc ctgggggctc tcttacagct gttctggcag 660 atattgaagt aatatggtct catgcgatac aaaaatactt ggaaatccca ctgaaagatt 720 taaagtatta tagatgtatc ttgttaattc ctgatatcta taataagcag catgtgaaag 780 aactagtgaa tatgatacta atga aga tgg gtt ttt tca ggg att gtg gtc 831 Arg Trp Val Phe Ser Gly Ile Val Val 1 5 cat cag gag tct gtg tgt gcc acc tat gga agt ggc tta agc agc acg 879 His Gln Glu Ser Val Cys Ala Thr Tyr Gly Ser Gly Leu Ser Ser Thr 10 15 20 25 tgt att gta gac gtt ggg gac cag aag aca agt gta tgc tgt gtg gag 927 Cys Ile Val Asp Val Gly Asp Gln Lys Thr Ser Val Cys Cys Val Glu 30 35 40 gat ggg gtg tct cat cgg aat act cgg ctt tgt ctg gca tac gga gga 975 Asp Gly Val Ser His Arg Asn Thr Arg Leu Cys Leu Ala Tyr Gly Gly 45 50 55 tct gat gtg tca aga tgt ttt tac tgg cta atg cag cga gct ggg ttc 1023 Ser Asp Val Ser Arg Cys Phe Tyr Trp Leu Met Gln Arg Ala Gly Phe 60 65 70 cct tac aga gaa tgc cag tta aca aat aaa atg gat tgt ctt ctt ctg 1071 Pro Tyr Arg Glu Cys Gln Leu Thr Asn Lys Met Asp Cys Leu Leu Leu 75 80 85 caa cac ctt aaa gaa act ttt tgt cat tta gat cag gac atc tct ggg 1119 Gln His Leu Lys Glu Thr Phe Cys His Leu Asp Gln Asp Ile Ser Gly 90 95 100 105 ctt cag gac cat gag ttt cag att cga cat cct gat tct cct gcc ctg 1167 Leu Gln Asp His Glu Phe Gln Ile Arg His Pro Asp S er Pro Ala Leu 110 115 120 ctt tac cag ttt cga tta gga gat gaa aaa ctg cag gct cca atg gct 1215 Leu Tyr Gln Phe Arg Leu Gly Asp Glu Lys Leu Gln Ala Pro Met Ala 125 130 135 ttg ttt tac ccc gca act ttt gga atc gtt gga cag aaa atg acg act 1263 Leu Phe Tyr Pro Ala Thr Phe Gly Ile Val Gly Gln Lys Met Thr Thr 140 145 150 ttg cag cac aga tct cag ggc gat cct gag gat cct cac gat gaa cat 1311 Leu Gln His Arg Ser Gln Gly Asp Pro Glu Asp Pro His Asp Glu His 155 160 165 tac ctg ctg gcc aca cag agc aaa caa gaa cag tct gca aaa gct act 1359 Tyr Leu Leu Ala Thr Gln Ser Lys Gln Glu Gln Ser Ala Lys Ala Thr 170 175 180 185 gct gac cga aag tct gca tcc aaa cct att gga ttt gaa ggg gat ctt 1407 Ala Asp Arg Lys Ser Ala Ser Lys Pro Ile Gly Phe Glu Gly Asp Leu 190 195 200 cgt ggc cag tcc tct gat ctt cca gaa aga ctc cat tcc cag gag gta 1455 Arg Gly Gln Ser Ser Asp Leu Pro Glu Arg Leu His Ser Gln Glu Val 205 210 215 gat ttg ggg tct gca cag gga gat ggc ctg atg gcc ggc aac gat tcc 1503 Asp Leu Gly Ser Ala Gln Gly A sp Gly Leu Met Ala Gly Asn Asp Ser 220 225 230 gag gag gcc ctc act gca ctg atg tcc agg aag act gcc atc tcg ctg 1551 Glu Glu Ala Leu Thr Ala Leu Met Ser Arg Lys Thr Ala Ile Ser Leu 235 240 245 ttt gaa gga aaa gcc ctg ggc ctg gat aaa gcc atc ctc cat agc ata 1599 Phe Glu Gly Lys Ala Leu Gly Leu Asp Lys Ala Ile Leu His Ser Ile 250 255 260 265 gac tgc tgt tca tct gac gac acc aaa aag aag atg tac ag atc 1647 Asp Cys Cys Ser Ser Asp Asp Thr Lys Lys Lys Met Tyr Ser Ser Ile 270 275 280 cta gtg gtg gga ggt ggt ttg atg ttt cat aaa gct caa gaa ttt ctg 1695 Leu Val Val Gly Gly Gly Leu Met Phe His Lys Ala Gln Glu Phe Leu 285 290 295 cag cac aga att ctc aac aaa atg cca cca tcc ttc agg cga att att 1743 Gln His Arg Ile Leu Asn Lys Met Pro Pro Ser Phe Arg Arg Ile Ile 300 305 310 gaa aat gtg gat gtg atc agg cct aag gac atg gac ccc cgg ctg 1791 Glu Asn Val Asp Val Ile Thr Arg Pro Lys Asp Met Asp Pro Arg Leu 315 320 325 att gca tgg aaa gga ggg gca gtg ttg gct tgt ttg gat aca aca cag 1839 Ile Ala Tr p Lys Gly Gly Ala Val Leu Ala Cys Leu Asp Thr Thr Gln 330 335 340 345 gaa ctg tgg att tat cag cga gag tgg cag cgc ttt ggt gtc cgc atg 1887 Glu Leu Trp Ile Tyr Gln Arg Glu Trp Gln Arg Phe Gly Ar Met 350 355 360 tta cga gag cgg gct gcg ttt gtg tgg tgaatgggga ggaaatgtca 1934 Leu Arg Glu Arg Ala Ala Phe Val Trp 365 370 ctgccgaaga ccaaaaacaa gcttcttggt ataaaagact cttacagaat atgtgtattg 1994 taatttattg atctggatgc ttaagtgtca tggacagtaa atgaatttga actttatgtt 2054 gaggacatga cattggtttg aaaatataaa ctgcttttga gcagtttagt cagggcattt 2114 gagaataaat aggaactttc tcttcagttg taaactctct tgccctctct cagggtctca 2174 taaactcccc agtgatgtaa acgttgctat tgaaggttct catgtggtga agcccttcat 2234 ttaagttggc ttgaatctca tcagcaggca gcctcatgca accatgaggg atagtatgtg 2294 acgagggaga actgtccact catgccattt tctctcttgt ctagtatttc attaggatct 2354 aaagttgtct gagttaaatg cacttatgtg actcatgtgt cctcttagaa tcccaaatag 2414 ggggaaaaag ttttggtggt ttttgttttt ttttcatttt ctgttggatt acagaaaaag 2474 aatgggaccc attcaggtct cgatttccaa aggta aagat ggaaggctgg gcagactggc 2534 ttttgttacc tgacatgccg tagggtgagc ttagaggaag aaagaaaaca atttttattt 2594 ggccaaaaca gaacaaatgc tgaaaaggaa atcttgtttt tttcctaaag ccaaatagaa 2654 atgatttggg tataatttaa gagtccttgt gttgtacaga tatggtgact gatgtagtta 2714 ttaatactac caacttagtc atcaagcctc aattttcctt tacctgaagg attaagtgaa 2774 agcttttgga gttcatgatg ttcagtatga tcagttaacc ttaacctctg agcatcctga 2834 agcaaaatct aaataatgca gctattacca ctggtggtcc aggctctggt gaagccctct 2894 gagcccagga ggaagagaaa gcattgtcca gaggtaggaa cacagtctgg gagcccagag 2954 ctctgggagg agtgggaaaa tgctgcttcc tgctgcttgc ttctaggcac ctgcttccgc 3014 catctcactt accatggcta gagatggggg tgagactggg gaaggacaaa agcagggaac 3074 agataaggga tggaaatcag aagggaatat agaaagaact ctggatgtgg agaaatgccg 3134 gtacctgagc attttgtatc aatgggagta ccctctgtaa ctgctcagta ggttacaaat 3194 gaagagtcca ccagtattag aaacaattta aacttgccag taccaactgg gatgtgtgcc 3254 ttcaatttga aaattgtatg ttttattttt taaatttgtt aacagcatta atttatagag 3314 tattgatgtc atttatgttt ctgaggtgtt tcaacacaat tttggatcag ctgcctgttt 3374 gcaaaaacat aatatatttc tgttaaacag ttcttcacct aacagcatat tgctcttata 3434 actggtagag ctgtttcaaa ggaagttggt ttctggtcca agttttgacc taaaccatgt 3494 ccatcttcta ttaccagcac ttacaagcac tgtgaaaact gatcatgaca aataagtaaa 3554 atttgctaca ttaaacatat tgcctcagcc attactaagc gtccacttgt aaagctggac 3614 acagttttta ctttatgctt cattttgatt ttttatccgt aagacataaa ttagaaggca 3674 tgaggtggcc ctttaaggat aatctgcaaa tatacacatt ttaatagtca tccatctgaa 3734 atcgatccac attccagaga agattcagta ttgtgctgtg tgaaataagc attcccagaa 3794 aaaaaacatt tatgctaata atacaacata acctctgcat taaagaaaaa gatgctttta 3854 ggccaggcgc cgtggctcac acctgtaatc cctgcacttt gagaggctga ggtgggtgga 3914 tcatgaggtc aggagatcaa gaccacaggc ttacaccatc acactcagct aattttttga 3974 atcttttgta gagatggagg tctcgctttg tgacgtagcc tggtcttgag cgatcctttt 4034 gccttggcct tgccaaagtg ctgggattgg aggcatgagc cactgcaccc acccctgttt 4094 tttatttaag taaaccatta taataactca tttataaaaa ggttacttca agagggcttt 4154 caacttaaga attattttca ttttgaacat gaaaagttaa atagta acta agaaactgag 4214 aactctgaca gtgacctcta ataggtaact ttaggcaaaa gtagacaagt ttgtgggtat 4274 tttgttgttc atgttaaaag gcacctgtac aagaatcaag atatgaatct agtttgtaga 4334 gggaaggtct tatgcaaata ccaaatcata caagtggtta cacatataat agatcatttg 4394 gtccagtaaa agtgggttca gcttgtttat tccctacttt tgttatctta aaaacaatga 4454 ttttttgcat gtaatagaag gtttttcact taagatgcta ttgagtgaat cagtgagggg 4514 ttcttagagt tagtattcat taattaaaca tagaatatta gctaaacagt tctgggtaca 4574 ctgcaatgca tggtctatgg aagactagat gtttggctga agatgcttta ttgttgcatt 4634 atcaaaatgg ttatagtttt caattaaaac tgtaattgat ttctatgtat aaaacagctt 4694 tgaagttgta aatgtagttt ccaatcgtta gttaatgcta cattagttag caatatttga 4754 aaattttatt ggtataaaat gttttaatta ctaaggctgt ttgtaggctg catagtaagc 4814 ttcaggatca tcacacgttt tttccctgta attggtggga taggaagcct ttaaggtctc 4874 ttgcttctca tgggtgggct acaaggagca gcagccatcg tggcaggctt gtgatctttt 4934 tcctgctgac acctgctgct tgacatggag aagttctgca cagaaagcag tggcatcctt 4994 catgaggtgg tacttggggc agacactgag agcattgtaa tcgtcttttg t atcaatctc 5054 tctaaagtag accaccacgt atttgtgcag atgaatctgg cttcttagat cactgcagaa 5114 aaggttaaag gcaaggggga agaggtcttg agagttctca ctgggactgc cctcgctctt 5174 gccacaggta ccatcgcaca cactgttgac gtcattggaa agaaggaaga cgactttgtc 5234 tgctgccttc ttttgagtgg caagccactg cactggaccc atctctgcta ttttcttttt 5294 ctgccacttt tcaaggatga cctcacttct gcaatggttt tgaagaaatt cagtgaagta 5354 acaaattgtg tgatggaaac atatttcaga tgggtaaacc acaagaacct taatgggggg 5414 cagtagtgtg gtggtagaaa aggaagtctt cttgatcctt tctgtgagag gagaaaagca 5474 tttgttatct gtgaacagca aacagcaggc tttcactctg taaaccatcc ctgacaaatg 5534 atcccttgct agagaatgtc agctgagcac caagggcctt gttagtgaca gcaaggaaaa 5594 acatcctgat gttccttttg aacacatcac ctgaaacaca ctgatgctta aaccttaact 5654 tttttttttt tggagacata gtctcactct gtcgcccagg ctggagtgca gtggcgtgac 5714 ctcggctgac tgcaacctcc gcctcctggg ttcacgccat tctcctgcct cggcctcccg 5774 agtagctggg actacaggcg cccgccacca cgcctggcta atttttgtgc ttttggtaga 5834 gacggggttt cgccctgtta gccaggatgg tctcgatctc ctgacctcgt gttccg cccg 5894 cctgggcctc ccagagtgct gggattacag gcgtgagcca ccgcaccctg ccttaaacct 5954 taacttttta aaccttattt taaaagcagt attttctaag tccctctcac taaaacaatc 6014 ctctcaacca agccttctct tttcagataa attcatagaa actttaggtt taagatactt 6074 tgttggccag gtgtggtggc ttacgccagg aatcccagca ctttgggagg ccaaggctgg 6134 tagatcactt gagtccagga gttccagacc agccagggca acatggcgaa accccatctc 6194 aacaaaaagt acaaatattg gctgggcttg atggcgtgca tctgtggtcc cagctactcg 6254 ggcggctaag gtgggaggtt cacttgagct caggaggcgg aggttgcggt gagccaagat 6314 cgcgccattc cactccagcc tgggcaacag agtgagaccc tgtctcaaaa aaaaaaaaaa 6374 aaaaaatact ttgaggtgtg tgattgtaac ctcagtactt ttagtgctgt atatgaacag 6434 ggacacttga cctctgcact tcacattttg agtcgggtca attaggtagt tgcttgtact 6494 gtcttctacc tgcaggtggt agagtttctt tatagttccc aaagttaagt ggcacccctt 6554 ttcagcccct ggaacttaac ctggaattct gccctatacg gtgctgtaaa acaaaccatg 6614 tttgaaacta ctgtaacgaa tacaggtcag acagcatccc taaatgtaag aattcctgag 6674 gtccaggtgc ccctgtggct ttcttagctt agaacatgga gttaatctca ttttatttac 6 734 aacatcacaa atgactcaaa ggatgcattt gtatttcctt tcctacatat ggagaagagg 6794 agttttttta atagctctgc cttgagctga gtatgtaaat gctctggttt ctgtattcaa 6854 atactccatg ttttgaagtt agcaaagccc ttagagagta cagctgaccc ttgaacaaca 6914 cagtggggag gggcaccggc cctgcatgca gttgaaaatc tcctataacc tttgattttc 6974 ccacaactta acttctaata gcctactgtt gactggaagt cttaccaata acataaacag 7034 ccaattaaca catattttgc atgttatgtg tattatgtgc tgtattataa taaagtaagc 7094 tagagaaaaa aatgtaatta aaatcatgag aaaatatatt tactaattca ttaaatggaa 7154 gtggaccatc 7164 <210> 60 <211> 7522 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (48) .. (3623) <400> 60 aaagattgct ttcttctggg acgctgcttg aacgctaacc gcgttga ttg gaa cag 56 Leu Glu Gln 1 att ttg tgt ctt ggc tgg ctt tgg gtg aag acc ggg gag aaa agg ttg 104 Ile Leu Les Glue Glug Trp 5 10 15 cgc tgc gat tct caa gat ctc tgg acc tgg att atc att gca aat cca 152 Arg Cys Asp Ser Gln Asp Leu Trp Thr Trp Ile Ile Ile Ile Ala Asn Pro 20 25 30 35 tta aag aag gag aag caa gcg gat ttc aga gag gtt gtt ctt cag aaa 200 Leu Lys Lys Glu Lys Gln Ala Asp Phe Arg Glu Val Val Leu Gln Lys 40 45 50 aaa atg gtt att tct ttg aac tca tgc ctg agc ttt att tgt tta ttg 248 Lys Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu 55 60 65 tta tgc cac tgg att ggg aca gca tca cct ctg aat ctt gaa gac cct 296 Leu Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro 70 75 80 aat gtg tgt agc cac tgg gaa agc tac tca gtg act gtg caa gag tca 344 Asn Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser 85 90 95 tac cca cat ccc ttt gat caa att tac tac acg agc tgc act gac a tt 392 Tyr Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile 100 105 110 115 cta aac tgg ttt aaa tgc acg cgg cac aga gtc agc tat cgg aca gcc 440 Leu Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala 120 125 130 tat cga cat ggg gag aag act atg tat agg cgc aag tct cag tgt tgt 488 Tyr Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys 135 140 145 cct gga ttt tat gaa agc ggg gaa atg tgt gtc ccc cac tgt gct gat 536 Pro Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp 150 155 160 aaa tgt gtc cat ggt cgc tgt att gct cca aac acc tgt cag tgt gag 584 Lys Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu 165 170 175 cct ggc tgg gga ggg acc aac tgc tcc agt gcc tgc gat ggt gat cac 632 Pro Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His 180 185 190 195 tgg ggt ccc cac tgc acc agc cgg tgc cag tgc aaa aat ggg gct ctg 680 Trp Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu 200 205 210 tgc aac ccc atc acc ggg gct tgc cac tgtgct g cg ggc ttc cgg ggc 728 Cys Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly 215 220 225 tgg cgc tgc gag gac cgc tgt gag cag ggc acc tat ggt aac gac tgt 776 Trp Arg Cys Glu Asp Arg Gln Gly Thr Tyr Gly Asn Asp Cys 230 235 240 cat cag aga tgc cag tgc cag aat gga gcc acc tgc gac cac gtc acg 824 His Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr 245 250 255 ggg gaa tgc cgc tgc cca cca gga tac acc gga gcc ttc tgt gag gat 872 Gly Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp 260 265 270 270 275 ctt tgt cct cct ggt aaa cat ggt cca cag tgt gag cag aga tgc c 920 Leu Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro 280 285 290 tgt caa aat gga gga gtg tgt cat cac gtc act gga gaa tgc tct tgc 968 Cys Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys 295 300 305 cct tct ggc tgg atg ggc aca gtg tgt ggt cag cct tgc ccc gag ggt 1016 Pro Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly 310 315 320 cgc ttt gga aag aac tgt tcc caagaa tgc cag tgc cat aat gga ggg 1064 Arg Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly 325 330 335 acg tgt gat gct gcc aca ggc caa tgt cat tgc agt cca gga tac aca 1112 Thr Cys Asp Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr 340 345 350 355 ggg gaa cgg tgc cag gat gag tgt cct gtt ggg acc tat ggc gtt ctc 1160 Gly Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu 360 365 370 tgt gct gag acc tgc cag tgt gtc aac gga ggg aag tgt tac cac gtg 1208 Cys Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val 375 380 385 agc ggc gca tgc ctc tgt gag ggg ggc gtt cgc tgc gaa 1256 Ser Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu 390 395 400 gca cgc ctg tgt cct gag ggg ctc tac ggc atc aaa tgt gac aaa cgg 1304 Ala Arg Leu Cys Pro Glu Gly Ile Lys Cys Asp Lys Arg 405 410 415 tgt ccc tgc cac ttg gaa aac act cat agc tgt cac ccc atg tct gga 1352 Cys Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly 420 425 430 435 gag tgt g cc tgc aag ccg ggc tgg tca gga ctc tac tgt aat gag aca 1400 Glu Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr 440 445 450 tgt tct cct gga ttc tac ggg gaa gct tgc cag ag atc tgc 1448 Cys Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys 455 460 465 caa aat ggg gca gac tgt gac agt gtg act gga aag tgc acc tgt gcc 1496 Gln Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala 470 475 480 cca gga ttc aaa gga att gac tgc tct acc cca tgc cct ctg gga acc 1544 Pro Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr 485 490 495 tat ggg ata aac tgt tcc tct cgc tgt ggc tgt aaa aat gat gca gtc 1592 Tyr Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val 500 505 510 515 tgc tct cct gtg gac ggg tct tgt act tgc aag gca ggc tgg cac ggg 1640 Cys Ser Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly 520 525 530 gtg gac tgc tcc atc aga tgt ccc agt ggc aca tgg ggc ttt ggc tgt 1688 Val Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys 53 5 540 545 aac tta aca tgc cag tgc ctc aac ggg gga gcc tgc aac acc ctg gac 1736 Asn Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp 550 555 560 ggg acc tgc acg tgt gca cct ggg tgg gag aaa tgc gaa ctt 1784 Gly Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu 565 570 575 ccc tgc cag gat ggc acg tac ggg ctg aac tgt gct gag cgc tgc gac 1832 Pro Cys Gln Gly Gly Thr Leu Asn Cys Ala Glu Arg Cys Asp 580 585 590 595 tgc agc cac gca gat ggc tgc cac cct acc acg ggc cat tgc cgc tgc 1880 Cys Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys 600 c 605 610 ctc gga tgg tca ggt gtc cac tgt gac agc gtg tgt gct gag gga 1928 Leu Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly 615 620 625 cgc tgg ggc ccc aac tgc tcc ctg ccc tgc tac ggt aaa a 1976 Arg Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala 630 635 640 tca tgc tcc cct gat gat ggc atc tgc gag tgt gca cca ggc ttc cga 2024 Ser Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Al a Pro Gly Phe Arg 645 650 655 ggc acc act tgt cag agg atc tgc tcc cct ggt ttt tat ggg cat cgc 2072 Gly Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg 660 665 670 675 tgc agc cag aca tgc cca cag tgc gtt cac agc agc ggg ccc tgc cac 2120 Cys Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His 680 685 690 cac atc acc ggc ctg tgt gac tgc ttg cct ggc ttc aca ggc Icc ctc 2 Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu 695 700 705 tgc aat gaa gtg tgt ccc agt ggc aga ttt ggg aaa aac tgt gca gga 2216 Cys Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly 710 715 720 att tgt acc tgc acc aac aac gga acc tgt aac ccc att gac aga tct 2264 Ile Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser 725 730 735 735 tgt cag tgt tac ccc ggt tgg att ggc agt gac tgc tct caa cca tgt 2312 Cys Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys 740 745 750 755 cca cct gcc cac tgg ggc cca aac tgc atc cac acg tgc aac tgc cat 2360 Pro Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His 760 765 770 aat gga gct ttc tgc agc gcc tac gat ggg gaa tgt aaa tgc act cct 2408 Asn Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro 775 780 785 gg tgg aca ggg ctc tac tgc act cag aga tgt cct cta ggg ttt tat 2456 Gly Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr 790 795 800 gga aaa gat tgt gca ctg ata tgc caa tgt caa aac gg gct tgc 2504 Gly Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys 805 810 815 gac cac att tct ggg cag tgt act tgc cgc act gga ttc atg gga cgg 2552 Asp His Ile Ser Gly Gln Cys Thr Cys Arg Thr G Phe Met Gly Arg 820 825 830 835 cac tgt gag cag aag tgc cct tca gga aca tat ggc tat ggc tgt cgc 2600 His Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg 840 845 850 cag ata tgt gat t aac aac tcc acc tgc gac cac atc act ggg 2648 Gln Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly 855 860 865 acc tgt tac tgc agc ccc gga tgg aag gga gcg aga tgt gat caa gct 2696 Thr Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala 870 875 880 ggt gtt atc ata gtt gga aat ctg aac agc tta agc cga acc agt act 2744 Gly Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr 885 890 895 gct ctc cct gct gat tcc tac cag atc ggg gcc att gca ggc atc atc 2792 Ala Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile 900 905 910 915 att ctt gtc cta gtt gtt cct ctc ctg gca ttg ttc att att tat 2840 Ile Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr 920 925 930 aga cac aag cag aag gga aag gaa tca agc atg cca gca gtt acc tac 2888 Arg His Lys Glns Lys Glu Ser Ser Met Pro Ala Val Thr Tyr 935 940 945 acc cct gct atg agg gtc gtc aat gca gat tat acc att tca gga acc 2936 Thr Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr 950 955 960 ctt cct cac agc aat ggt gga aac gct aat agc cac tac ttc acc aat 2984 Leu Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn 965 970 975 ccc agt tac cac acg ctc acc cag tgt gcc aca tcc cct c ac gtc aac 3032 Pro Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn 980 985 990 995 aac agg gac agg atg act gtc acg aag tca aaa aac aat caa ctg ttt 3080 Asn Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe 1000 1005 1010 gtg aat ctt aaa aat gtg aac cct ggg aag aga ggc cct gtg ggg gac 3128 Val Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp 1015 1020 1025 tgc act ggg aca ttg ccg gct gac tgg aaa cat ggc ggc tac ctc aac 3176 Cys Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn 1030 1035 1040 gag ctc ggt gct ttt gga ctt gac aga agc tat atg gga aaa tcctta Leu Gly Ala Phe Gly Leu Asp Arg Ser Tyr Met Gly Lys Ser Leu 1045 1050 1055 aaa gac ctg gga aag aat tct gaa tat aat tca agt aac tgc tcc cta 3272 Lys Asp Leu Gly Lys Asn Ser Glu Tyr Asn Ser Ser Asn Cys Ser Leu 1060 1065 1070 1075 agc agt tct gag aac cca tat gcc act att aaa gac cca cct gta ctt 3320 Ser Ser Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp Pro Pro Val Leu 1080 1085 1090 atc ccg aaa agc tca gag tgt ggt tat gtg gag atg aaa tcg ccg gca 3368 Ile Pro Lys Ser Ser Glu Cys Gly Tyr Val Glu Met Lys Ser Pro Ala 1095 1100 1105 cga aga gat tcc cca tat gca gag atc aat aac tca act tca gcc aac 34 Arg Arg Asp Ser Pro Tyr Ala Glu Ile Asn Asn Ser Thr Ser Ala Asn 1110 1115 1120 agg aat gtc tat gaa gtt gaa cct aca gtg agt gtt gtc caa gga gta 3464 Arg Asn Val Tyr Glu Val Glu Pro Thr Val Ser Val Val Gln Gly Val 1125 1130 1135 ttc agc aat aat ggg cgt ctc tcc cag gat cca tat gac ctc cca aag 3512 Phe Ser Asn Asn Gly Arg Leu Ser Gln Asp Pro Tyr Asp Leu Pro Lys 1140 1145 1150 1155 aac agt cac atc cct tgt cat gac ctg ctg cca gtc cga gac agt 3560 Asn Ser His Ile Pro Cys His Tyr Asp Leu Leu Pro Val Arg Asp Ser 1160 1165 1170 tca tcc tcc cct aag caa gag gac agt gga ggt agc agc agc aac agc 3608 Ser Ser Ser Pro Lys Gln Glu Asp Ser Gly Gly Ser Ser Ser Asn Ser 1175 1180 1185 agc agc agc agt gaa tgacaccaaa ggaccgcttg gtagccactg gaaccctttc 3663 Ser Ser Ser Ser Glu 1190 cagaactgct gtttggttct tc tccatcct caattttgcc actttcatgt gaatgttagt 3723 caattcggtg ggcaattttt ggacatgaac cagaaagctg aaagctgagg ctgacacgga 3783 ctgtaggtgc tttttgttca ggtggattcg aaggagttag agatgtgatt tgccattgct 3843 gttagtttta gaactatacc cgtgaagcat gacttattgt aagatgttgg ctgaaagcat 3903 gaacttgcag aactccctcg gagacgcagg ttgcagtgga cattgggatt gttgcttgaa 3963 aaattaaaat ttgaatattt tctctctcat ttgcatcata cagctctacc taggattgta 4023 cagtttacca taaaatttac ttcatgaaag tgggaatcac tgaacatgta gaagacaagg 4083 aacatattgt taactcctga ttcttaactt tattcaactg gactcagaat tgtagggata 4143 atatgaatgc aggaggaaac attctgtcag gcggtatgac tggacagact ttgaatatac 4203 tctaaaagtg gacagaaaat ttacgaaaat cttagatttt gtttagaatg agaaaatata 4263 caattagaat tattttagaa atagtaggaa gtattgcaga agtcaataca caaatgtgcc 4323 aggcagaggt ggttttctct gtttgactct caaccaactt cagatctatg acattattct 4383 gatcactggc tccatcatac atattcacca cttgagattc ataacatatc aatagttatt 4443 tcataaatat agaaatgaaa taattttatt tttgacagac tggatggaat gagtgtgtaa 4503 tgattgataa aggttgtaaa ttttaaat gc aagatgacgc ttacgttctg taaaccatta 4563 gtaatacatg ctgtaatata gaattagtgg aacattttga ttaatctttc cctagaagtg 4623 actgaaatat ttttgtgcat atttgagaaa gggaactttc cttttattaa ttgtcaattt 4683 agagaaacta tgcttaagct ggtcttttgc attgctaatg tgacatgtac ccaacttttc 4743 attaatttgt atttccattt ttaaattgca tattctatgt tttgtagtgt ttggattgtt 4803 aatgaaaaaa tattatatgt tcgttattcc ttgtattatt gccacttatc ttttgcttga 4863 taaaaatgcg ttgttctttt ttcttttgga gggacaagat gaaaatatat aatttgaatt 4923 gattaaaatt ggtcgttact aaaatagtat agtaaccaca agtgattggc ttataaatga 4983 agtagaaatg ctttttaata ttccaaaata gagttccttt tgatctgttg gtgctgagcc 5043 ttggttaaac cagggagaag gggagcagaa aggaaacgtt gttactgatg agtaccacag 5103 actcatctta aaaaaaactc tcattatggt gatcatagaa ttgaccatcc aaactgggac 5163 actcttgaga gtaaatggag ggcattatta ataattatct tgtaatgaac ttaaatctgg 5223 actgttccag gcaaaccaga cttatcttgc aatatgagaa tgctgacaca atgcaggaaa 5283 gccagtttcc cttttgttga tctacttgac caagcaaagg ggctgaaaaa ctgaataagg 5343 aaacaacttt ataagagaaa cagtggtctt caa tctttta aagacatgaa atcctatatg 5403 gcattctgtc tcagtgagtc agttaacaaa tacgtatgtg caacccttct gctagtagtg 5463 cacataagtg attatccctg ccaggtatcg agttggaata tccagttatt tcatgtcaca 5523 catcggcacg tatgatggtg gtttggtcag atggataata cagcagacac acttagaaca 5583 ctcactgcac tggtggctgt tcattttgag gaactccaaa gtcaattcaa ggaaataagg 5643 aatgacctgg aacaggcctt agaaacaatt gatttattcc aatagttaac cactggctgg 5703 ctcccaactc taggtgatag gcatctaatt gagacatgtg tgagtcaata gccatcgggg 5763 tcctttttgg tgagaagaaa taagacattt tctccctttt aaagatcatc tcttcagagc 5823 tgcatggtaa atttgaattt ccccattgtt ctctagagat aggtcaaaaa aacaactgtt 5883 tcttttctta ttccactatt aataaattga aagcttgctg tacaaaggca acagcaactt 5943 aaaaaagaaa atctggacaa tagatgtgga ctccaagggg ccactgccat cccttcctgt 6003 gtgctctttt tgacaagtaa atcactccag ttagctgatg tcctgaaatg acatttgtac 6063 ctgaggcaat tcttattaga gcttactcag gacttttcaa acatcaggac acacatagca 6123 atttggatgt tgtaaaacta cgtgttacat ttggagaggt cttgttgaga aggcaaaatt 6183 ttctaaatat tttgatatca atttgggtaa agaaagga at acttttgtta gaatgagaat 6243 taaagagaaa acaaaagaat cttggcaaaa ttttccctct gaaattacaa actttaggaa 6303 cttttccaga tgtatcgaat ttaatttgac attgatgtca ctcttcatac caagtgaatc 6363 tattctcatg aactttgaac ccatgttaat tttggaccct ataactaatt tcctttctgt 6423 atcccatggt ggtcaaagca gtaaaggagt ttagagatac ttagcaaatg ccattcatat 6483 agtattgtta gccaaactat tattccttcc ttagaagttg atgtatcaga aaatttataa 6543 gttatttgta tttatatata agtacatcag aacttgccca catgataact catgtttgct 6603 ttaataagga aaatatgtta tttgaggtta attatatgat agtgaggaac attttacaat 6663 tatttacagt gtttgacatt aattgctgtc ctatgataca gtagtaatgt taacagagag 6723 tttaatatgt ttagcattat ctttatggaa tttatattca ccaatttcag gaaaaccaac 6783 catagaactt tataatagga cagttataac ctgactgaac caaatccatc agcataatga 6843 ctgtgtgttc tgagaaatgc aaacaacttt atgaaagtgt ggtcatcttg acccccaaag 6903 agccacagta gctgtcaatt attgagattt ttaaatggta aatattgcaa aagttaaaca 6963 agggtaccac aatatcattt ataattgatg tcaatattag tagtccactt tatgcttaaa 7023 ataaaatcat aaaaaatcaa gttttaaggt tatatttttt aaa ataatga attttctatc 7083 tctaggcaac atgtctttat tattcaagct gaatgtttaa gagagatttt ggtcttaaag 7143 gcttcatcat gaaagtgtac atgcatatgc aagtgtgaat tacgtggtat ggatggttgc 7203 ttgtttatta actaaagatg tacagcaaac tgcccgttta gagtcctgtt aatattgatg 7263 tcctaacact gggtctgctt atgctagttc agtatttggt ctaggcttca ttttgatatg 7323 actgaattgc aatctatatt tttaaaaaga aaaatcaaaa tacattaggg tttacttggt 7383 tgtggcaaac aaacaaaaaa tgctttcagt gttgaaatat ctctattttc caaagatgat 7443 aaactttcat cgttcttagc ctacattgtc atttatatca ccaaatgagt ttatagatta 7503 atgcaataaa ctttctaat 7522 <210> 61 <211> 6216 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (195) .. (1217) <400> 61 gcgggcaagg cgggcggagc gcactggaac tcaagggggc gcacagcggc gcgctcgcac 60 cgctcggctc cgcgcggctc taggaggtgg cggcggtggc ggtggcggcg gtggcggcgg 120 cggcggcggc ggggcgcagg gctgagcgag cgtccgggtt ccggggctcc ggggaaggcg 180 gttgcagctc ctga gtg cag cgc ggc ttc ctg cca ctg tcc cgg ccc ggc 230 Val Gln Arg Gly Phe Leu Pro Leu Ser Arg Pro Gly 1 5 10 cac ctc tct gtc atg gct ctg gcg gac agc aca cgt gga tta ccc aac 278 His Leu Ser Val Met Ala Leu Ala Asp Ser Thr Arg Gly Leu Pro Asn 15 20 25 ggg ggc ggc ggc ggg ggc ggc gg tcc tcg tcg tcc tcc gcg gag 326 Gly Gly Gly Gly Gly Gly Gly Ser Gly Ser Ser Ser Ser Ser Ala Glu 30 35 40 cca ccg ctc ttc ccc gac atc gtg gag ctg aac gtg ggg ggc cag gtg 374 Pro Pro Leu Phe Ile Val Glu Leu Asn Val Gly Gly Gln Val 45 50 55 60 tac gtg acc cgg cgc tgc acg gtg gtg tcg gtg ccc gac tcg ctg ctc 422 Tyr Val Thr Arg Arg Cys Thr Val Val Ser Val Pro Asp Ser Leu Leu 65 70 75 tgg cgc atg ttc acg cag cag cag ccg cag gag ctg gcc cgg gac agc 470 Trp Arg Met Phe Thr Gln Gln Gln Pro Gln Glu Leu Ala Arg Asp Ser 80 85 90 aaa ggc cgc ttc ttt ctg gac cgg gac ggc ttc ctc ttc cgc tac atc 518 Lys Gly Arg Phe Phe Leu Asp Arg Asp Gly Phe Leu Phe Arg Tyr Ile 95 gat tac ctg cgg gac ttg cag ctc gtg ctg ccc gac tac ttc ccc 566 Leu Asp Tyr Leu Arg Asp Leu Gln Leu Val Leu Pro Asp Tyr Phe Pro 110 115 120 gag cgc agc cgg ctg cag cgc gag gcc gag tac gag 614 Glu Arg Ser Arg Leu Gln Arg Glu Ala Glu Tyr Phe Glu Leu Pro Glu 125 130 135 140 ctc gtg cgc cgc ctc ggg gcg ccc cag cag ccc ggc ccg ggg ccg ccg 662 Leu Val Arg Arg Leu Gly Ala Pro Gln Gly Pro Gly Pro Pro 145 150 155 ccc tcg cgg cgc ggg gtg cac aag gag ggc tcg ctg ggt gac gag ctg 710 Pro Ser Arg Arg Gly Val His Lys Glu Gly Ser Leu Gly Asp Glu Leu 160 165 170 ctg ccg ctt gc tac gag ccc gaa cag cag gag ggc gcc tct gcc 758 Leu Pro Leu Gly Tyr Ser Glu Pro Glu Gln Gln Glu Gly Ala Ser Ala 175 180 185 ggg gcg ccg tcg ccc acg ctg gag ctg gct agc cgc agt ccg Tcc ggg Prog 806 Ser Pro Thr Leu Glu Leu Ala Ser Arg Ser Pro Ser Gly 190 195 200 ggc gcg gcg ggc ccg ctg ctc acg ccg tcc cag tcg ctg gac ggc agc 854 Gly Ala Ala Gly Pro Leu Leu Thr Pro Ser Gln Ser Leu Asp Gly Ser 205 210 215 220 cgg cgc tcg ggc tac atc acc atc ggc tac cgc ggc tcc tac acc atc 902 Arg Arg Ser Gly Tyr Ile Thr Ile Gly Tyr Arg Gly Ser Tyr Thr Ile 225 230 235 ggg cgg gac gcg cag gcg gac gcc aag ttc gtg gcg cgc atc 950 Gly Arg Asp Ala Gln Ala Asp Ala Lys Phe Arg Arg Val Ala Arg Ile 240 245 250 acc gtt tgc gga aag acg tcg ctg gcc aag gag gtg ttt ggg gac acc 998 Thr Val Cys Gly Lys Thr Ser Leu Ala Lys Glu Val Phe Gly Asp Thr 255 260 265 ctg aac gaa agc cgg gac ccc gac cgt ccc ccg gag cgc tac acc tcg 1046 Leu Asn Glu Ser Arg Asp Pro Asp Arg Pro Pro Glu Arg Tyr Thr Ser 270 275 275 280 cgc tat tac ctc aag ttc aac ttc ctg gag cag gcc ttc gac aag ctg 1094 Arg Tyr Tyr Leu Lys Phe Asn Phe Leu Glu Gln Ala Phe Asp Lys Leu 285 290 295 295 300 tcc gag tcg ggc ttc cac atg gtg gcg tgc gcg tgcggcc tgc gcgcgggcc tgc 42 Ser Glu Ser Gly Phe His Met Val Ala Cys Ser Ser Thr Gly Thr Cys 305 310 315 gcc ttt gcc agc agc acc gac cag agc gag gac aag atc tgg acc agc 1190 Ala Phe Ala Ser Ser Thr Asp Gln Ser Glu Asp Lys Ile trp Thr Ser 320 325 330 tac acc gag tac gtc ttc tgc agg gag tgagctcccc agaccccctc 1237 Tyr Thr Glu Tyr Val Phe Cys Arg Glu 335 340 gccactccag cgcccagtcc ttctcctgcc cgagagatga ttacagagcc tcttgtccca 1297 cctttgtccc ctggctgctg ccctcccatt ctccccctcc agtagtagct gggtgagacc 1357 tgtccgccca ccttccctcc actacagaac ctgcagccgc aaatcctctg ggctgcttcg 1417 tcttctttgg acctcctgaa ccgagagaac ccagaggaac ccccacccca cccccaccta 1477 ccactccatg ctttctctac tccctgcctc aaaccacccc tcccccagat ggtacttcag 1537 tttggatcta ttgggggagt gtggccacag accgggggat gattgaattg ttcagaacct 1597 gattggaccg tgtccaatgt gcggaagatt tccttgaaat cttctcaagc tcttatgact 1657 cactgggggt ttaagagatc aggattggtt ccactgtctg gggttagtgt tttacaaggt 1717 cattacacag tctttttgac ctcttttgaa ggtagagttt tagaaggctg gatggaagat 1777 tctgagcctg gaattaggac cccatgg agg cagttcagta actaaactaa taaagttttg 1837 aaaagttaca cgtaaagtag aagaatctag tgcgtgggac agtaaaggat cctttctcgt 1897 acagaataaa aggtctcagc ctgtagctta aacttataga aagtgatccg cctgcctgca 1957 gaggcgccct tttcagctgc tgctcgccag aagcccttga ttccactggt tgacatggca 2017 gcagttactg gcaagaggga gaaaggacgc tgccgcctaa gagtgcaagg ctgctcaggt 2077 ctccaagcgc cgtaggaggt cacctggcag tgactgtagg gagctgggtc atagtgcacg 2137 tcgtgggtat taggaaagcc tgtattcttt caatgaatgt cagtaggacc ttcctttagc 2197 tgtaagactt ggtgggcggg gtggggtggg gagggaggaa agggtaggaa gggtgggaag 2257 ggagaagcag acatagtcat ttatgatttg aaagttggaa gtttgtacca tctgtttgag 2317 tatatgcaca tttaaaaaat atcatatagt aaatgcaaac atgccaagta ttttataaag 2377 attaataaca gacctactct tacctggcag tttacttaac ttactgtttt gagtcctaaa 2437 cttagagttg ttaatgctta tatataatct aaccaaagag ttacccagta gggttttagt 2497 ttttgaactt ttattttctt gttgattata aatcctgatt ttggaatcta ttgcgcaaaa 2557 gaagtttcat tttggttact tagacctaag atcacttatt aaaaatcctt attttctcca 2617 agcccagcaa acgttgactt ctgggcaaac ct gaaaacct gaaaatgcca ctttcatgca 2677 gtttgtttga agttaagtgg aatcctttca aatgacgagc tgcagagaac tcagcaccaa 2737 gggctgccta tctgtagata gctgtaaaat ggaatatttt taaatgaagg caaataagta 2797 cttaaaagtg agctgagcaa taaaatggtc caataatagg taaatgcaac agaaacagaa 2857 ggagacctgg ttgccttatg cctttactct tacatggaat aaattcccaa tgcatatcct 2917 atgtaaacca taagtgaagg gaaataaacc tcgtcatgct ccatgctgtg aggtgtcctt 2977 tggatattct gtgatgacag agaagcctat tttgttttgt tttcagcatc tttctctgat 3037 gtacgttttt aaggattttg taagagctgt tttcagtgtt taaattagtg ctatttttcc 3097 ttgtttttaa aaatgaatct cgtactgtat cttactatgt ccatacagat gttacaaatc 3157 gacagtttta ttcttagact catgtgatcc aagctgtata taccatatat aaacatttta 3217 catgaatcat ttagtttttt aattcattta ctaatgctat aaaatttcct atattacccc 3277 agtaatttgc atcagctggt ttatatacta aagcaacatg ttttgatgag tttcttacat 3337 ccttatcgag gaattgggtt aggaaaaaat acataattgt aaaactgagt ttgctgtatt 3397 atactttttt tcttgagtat tagttgtatt actaatcata tgttgattaa ctgtctactt 3457 aaagtcaagg tacctgtatt tttaatccac taattttt tt ttagttggga aatagatttc 3517 aagtctttta ttagactaac attttttgag aagtaaaatt gactttatat acaaagcctg 3577 taattttagg cgaaatggaa gcagaaatct aggaagttgt gcttgcttgt atggtctcag 3637 actaagtaat gcatcagaat tcatctgttt gaagcctgaa ataatttagg actctgattc 3697 actgaccaaa agtcagtgtt gcagagattt ctctaccccg tatggtattt tgttagattg 3757 ttcaacagga agcacatgat tgagaacatc ttgggacaga ccaaaaccac tgacagatgg 3817 caaggctcgg cgattctgat ttcccttctc aaatctgctc aactccaaga gtcttgagaa 3877 actgctaaaa ttttgcctct gtcactcaag tcttacaaat gttatcttgt aaacctttga 3937 ggtgaactat tccactgtct tgtacatagg catcttattc actgcaccct gtcacaccca 3997 gcaccccccg ccccgcacat tatttgaaag actgggaatt taatggttag ggacagtaaa 4057 tctacttctt tttccaggga cgactgtccc ctctaaagtt aaagtcaata caagaaaact 4117 gtctattttt agcctaaagt aaaggctgtg aagaaaattc attttacatt gggtagacag 4177 taaaaaacaa gtaaaataac ttgacatgag cacctttaga tcccttcccc tccatgggct 4237 ttgggccaca gaatgaacct ttgaggcctg taaagtggat tgtaatttcc tataagctgt 4297 aatagtggag gtattgtggg ttcatttgag taagccctcc aa agatacca ttcaaataac 4357 ctgggagaat gtcataaatt attcagataa ttatcactgc atgaatctga ttcagaggca 4417 tgcatttaca tatgttgccc taattaccat ttgatgatca taaatacaag tgaatgacat 4477 tggactttta gtaacaaact taatttttaa aaaagtgtag acaatggtgg ttaaaaaaaa 4537 aaaaaacagg tgccaggttc tgtgtgtttg caccaagtaa ttgacatgtt ttttgtttaa 4597 tacatgtgga ccatgaacag tattcattct actttttcaa atgatatgct gtagaaaata 4657 ttccttgaag atgtgagatt taaaaatttt tccctttcaa tgttgtttta attgtatttc 4717 ttacttggtt tttttgattg atagcacagt gataaatcat aatactagac aaaattgtct 4777 tctctttcaa accagagcca tatatatgtc tgtatatatg ggacctactg cttctctgag 4837 gaaatgcata atctgttaat atcagacaaa atgagcaatt ggcagtgctc ataatatatt 4897 ccaattttta ttggaatttt cgatggaatg ttatttcaat aaagccatgt aaggtgaaac 4957 tttgataact ttttactctt caagttaggg taaattctga tccaatattc aattcatttg 5017 tgtactccca catgcaaaat gctaaattac aatgcagaca ttaagaaaaa gtattgactg 5077 gaggggttga attccttgag aatttatttt atagtctaaa tcacaaatac tttactcaat 5137 ttagttttta aaatagtaaa ctgaatattt ttgttgtaag cctatcag ag tcaatccttc 5197 gtttggaatt gttttcctgt ttttccttac tataaatcat ttaaaaactg aattcatttt 5257 cttagatggc ataagtctgt ctcttgagaa ataagtaaaa tactcctatt ttcagtatct 5317 gtagcacctg aaataggtct ttgtatagcc agaaacaagt tatgttgaag ttagcttttc 5377 tttgtcaaca gttttggaca ataaaaatct gaaagtatta acacttgatt ttctactggg 5437 gcccttcaaa cttggttgga agaaattcaa ccagaatatc tacattagag tataatcatg 5497 tgtggtagga agatggacta gttaatcaag atttgttgtc acttaaattt tttgtgattt 5557 ttttccaagc cagttttttt aaattctaaa tgtgttttga ggtatgggta cattaattgt 5617 aatgtaaact attatacaac tgtttttgcg actttatagg caggtaaatt ttgctattac 5677 tattgaatac aaatgacaat tcatttatga ccactcaaac agcgttagta accatttagt 5737 gacaaaggat taaaacatcc atctggatgt taattttgaa gatgtaaatt atatgttgtt 5797 taaatttttc caggcatctg aaaaccttat ctgctagaca atgtaagatt cacacagagt 5857 tatctgggat tctgattttt taaatagtac atatcattaa accattttct ctaaatgtaa 5917 gaagagcaga aaaaatctta taagattatc agatttttct aatgacacag aaatgtaaga 5977 aaaaaatccc tttatattga aaaaagatgc agtcaaagtc ttttcagaca tgc ccaaact 6037 ttgagaattc cttcaaccat ctaatgctat aaagattttt gttcttcctg ttcacaacca 6097 gttgtataac agaaatacta gctactgttt tccttcctgt gtgtgaagta atgaatcatt 6157 gattatgtga cttgttatgt attcaattaa acactga <210> 62 <211> 4343 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1769) <400> 62 ct cag gag gtt ttt cag agt gga atc att cct tca gat act gac ttt 47 Gln Glu Val Phe Gln Ser Gly Ile Ile Pro Ser Asp Thr Asp Phe 1 5 10 15 cgt atc tac agg gat ttt ggg aac att cca gga ata gac tta gct ttt 95 Arg Ile Tyr Arg Asp Phe Gly Asn Ile Pro Gly Ile Asp Leu Ala Phe 20 25 30 att gag aat gga tac att tat cac acc aag tat gac aca gcg gac aga 143 Ile Glu Asn Gly Tyr Ile Tyr His Thr Lys Tyr Asp Thr Ala Asp Arg 35 40 45 att cta aca gat tcc att cag aga gca ggt gac aac att tta gca gtt 191 Ile Leu Thr Asp Ser Ile Gln Arg Ala Gly Asp Asn Ile Leu Ala Val 50 55 60 ctt aag cat cta gct aca tct gat atg ctg gct gct gct tct aag tat 239 Leu Lys His Leu Ala Thr Ser Asp Met Leu Ala Ala Ala Ser Lys Tyr 65 70 75 cga cat gga aac atg gtc ttc ttt gat gtg ctg ggc ctg ttt gtc att 287 Arg His Gly Asn Met Val Phe Phe Asp Val Leu Gly Leu Phe Val Ile 80 85 90 95 gcc tac ccc tct cgt att ggc tca atc ata aac tac atg gtg gta atg 335 Ala Tyr Pro Ser Arg Ile Gly Ser Ile Ile Asn Tyr Met Val Val Met 100 105 110 ggt gtt gtt ttg tac ctg ggc aaa aaa ttt ttg cag ccc aaa cat aag 383 Gly Val Val Leu Tyr Leu Gly Lys Lys Phe Leu Gln Pro Lys His Lys 115 120 125 act ggt aac tac aag aag gac ttc ttg tgt gga ctt ggc atc act ttg 431 Thr Gly Asn Tyr Lys Lys Asp Phe Leu Cys Gly Leu Gly Ile Thr Leu 130 135 140 atc agc tgg ttc act agc ctt gtt acc gtt ctc att ata gca gtg ttc 479 Ile Ser Trp Phe Thr Ser Leu Val Thr Val Leu Ile Ile Ala Val Phe 145 150 155 atc tct ctt att gga cag tct ctc tca tgg tat aac cac ttc tat gtc 527 Ile Ser Leu Ile Gly Gln Ser Leu Ser Trp Tyr Asn His Phe Tyr Val 160 165 170 175 tcc gtt tgt ctg tat gga act gca act gta gcc aaa ata ata ctt ata 575 Ser Val Cys Leu Tyr Gly Thr Ala Thr Val Ala Lys Ile Ile Leu Ile 180 185 190 cat act ctt gcg aaa aga ttt tat tac atg aat gcc agt gcc cag tat 623 His Thr Leu Ala Lys Arg Phe Tyr Tyr Met Asn Ala Ser Ala Gln Tyr 195 200 205 ctg gga gaa gta ttt ttt gac att tcg ctg ttt gtc cat tgc tgt ttt 671 Leu Gly Glu Val Phe Phe Asp Ile Ser Leu Phe Val His Cys Cys Phe 210 215 220 ctt gtt acc ctc act tac caa gga ctt tgc tcg gcg ttt att agt gct 719 Leu Val Thr Leu Thr Tyr Gln Gly Leu Cys Ser Ala Phe Ile Ser Ala 225 230 235 gtc tgg gta gca ttc cca ttg ctc aca aag ctc gtg cat aag gac 767 Val Trp Val Ala Phe Pro Leu Leu Thr Lys Leu Cys Val His Lys Asp 240 245 250 255 ttc aag cag cat ggt gcc caa gga aaa ttt att gct ttt tac ctt ttg 815 Phe Lys Gln His Gly Ala Gln Gly Lys Phe Ile Ala Phe Tyr Leu Leu 260 265 270 270 ggg atg ttt att cct tat ctt tat gca ttg tac ctc atc tgg gca gta 863 Gly Met Phe Ile Pro Tyr Leu Tyr Ala Leu Tyr Leu Ile Trp Ala Val 275 at 280 t285 gttag ttt acc cct atc ctc ggg aga agt ggt tct gaa atc cca 911 Phe Glu Met Phe Thr Pro Ile Leu Gly Arg Ser Gly Ser Glu Ile Pro 290 295 300 cct gat gtt gtg ctg gca tcc att ttg gct ggc tgt aca atg att ct Pro Asp Val Val Leu Ala Ser Ile Leu Ala Gly Cys Thr Met Ile Leu 305 310 315 tcg tcc tat ttt att aac ttc atc tac ctt gcc aag agc aca aaa aaa 1007 Ser Ser Tyr Phe Ile Asn Phe Ile Tyr Leu Ala Lys Ser T hr Lys Lys 320 325 330 335 acc atg cta act tta act ttg gta tgt gca att aca ttc ctc ctt gtt 1055 Thr Met Leu Thr Leu Thr Leu Val Cys Ala Ile Thr Phe Leu Leu Val 340 345 345 350 tgc agt gga aca ttt ttt cca tat agc tcc aat cct gct aat ccg aag 1103 Cys Ser Gly Thr Phe Phe Pro Tyr Ser Ser Asn Pro Ala Asn Pro Lys 355 360 365 cca aag aga gtg ttt ctt cag cat atg act aga aca ttc cat gac ttg 1151 Pro Lys Arg Val Phe Leu Gln His Met Thr Arg Thr Phe His Asp Leu 370 375 380 gaa gga aat gca gtt aaa cgg gac tct gga ata tgg atc aat ggg ttt 1199 Glu Gly Asn Ala Val Lys Arg Asp Ser Gly Ile Trp Ile Asn Gly Phe 385 390 395 gat tat act gga att tct cac ata acc cct cac att cct gag atc aat 1247 Asp Tyr Thr Gly Ile Ser His Ile Thr Pro His Ile Pro Glu Ile Asn 400 405 410 415 gat agt atc cga gct cac tgt gag gag aat gca cct ctt tgt ggt ttt 1295 Asp Ser Ile Arg Ala His Cys Glu Glu Asn Ala Pro Leu Cys Gly Phe 420 425 430 cct tgg tat ctt cca gtg cac ttt ctg atc agg aaa aac tgg tat ctt 1343 Pro Trp Tyr Leu Pro Val His Ph e Leu Ile Arg Lys Asn Trp Tyr Leu 435 440 445 cct gcc cca gaa gtt tct cca aga aat cct cct cat ttc cga ctc ata 1391 Pro Ala Pro Glu Val Ser Pro Arg Asn Pro Pro His Phe Arg Leu Ile 450 455 460 tcc aaa gaa cag aca cct tgg gat tct ata aaa ttg act ttt gaa gca 1439 Ser Lys Glu Gln Thr Pro Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala 465 470 475 aca gga cca agc cat atg tcc ttc tat gtt cga gcc cac aaa gca 1487 Thr Gly Pro Ser His Met Ser Phe Tyr Val Arg Ala His Lys Gly Ser 480 485 490 495 aca ctt tct cag tgg tct ctt ggc aat ggc acc cca gtc aca agt aaa 1535 Thr Leu Ser Gln Trp Ser Leu Gly Asn Gly Thr Pro Val Thr Ser Lys 500 505 510 gga gac tac ttt gtc ttt tac tcc cat gga ctc cag gcc tct gca 1583 Gly Gly Asp Tyr Phe Val Phe Tyr Ser His Gly Leu Gln Ala Ser Ala 515 520 525 tgg cag ttc tgg ata gaa gtg cag gtt tca gaa gaa cat cct gaa gga 1631 Trp Gln Phe Trp Ile Glu Val Gln Val Ser Glu Glu His Pro Glu Gly 530 535 540 atg gtc acc gtg gcc att gct gcc cac tat ctg tct ggg gaa gac aag 1679 Met Val Thr Val Ala Ile Ala Ala His Tyr Leu Ser Gly Glu Asp Lys 545 550 555 aga tcc cct caa ctg gat gct ctg aag gaa aag ttc cca gat tgg aca 1727 Arg Ser Pro Gln Leu Asp Ala Leu Lys Glu Lys Phe Pro Asp Trp Thr560 565 570 575 ttt ccc tct gcc tgg gtg tgc acc tac gat ctc ttt gta ttt 1769 Phe Pro Ser Ala Trp Val Cys Thr Tyr Asp Leu Phe Val Phe 580 585 taatcttgtg gatgagctct aagtacatgc ccagtggata ctccatgtga catggtttct 1829 ccctatgtta cgtggatgtt tgtaacgtaa gtcaatgaat tttaatgatc atatgttcaa 1889 agagctttct gggttaacgc ttttcagggc caagcactat aagggtttag ctgtggcgca 1949 gtgatgcatg gcctgttgac acttgaaaat gccagtcttt tggcacttca gcacatgtgg 2009 gtactgccac tacacacacg tcattttata tgaccttaag gacaaagcca acaatctact 2069 tcaatagctg cccctttagg atcaagaaag atgtacactg tcagagcatt gttaatgaga 2129 caaaagttgt ttccaattta agccccaaaa ccatttgttg tattagtgga tggtgggtaa 2189 aatatcattc actgaggtaa tgattcccct tgagaatata actctgtgta ggtcactgga 2249 aagtgattgc catagggctg ggagagaagc attgcactct tgaggctgta gcctgtgtca 2309 agctgtttct tcaggcagcc tctcaaatgt gctttgtctc tctgtgctga ggcctggacc 2369 ctgtgctgag ctggtgactc actgtcctga caagtggaca cacagatgca ctgctgtgct 2429 gctttcctga ggtggttttc tatgcctgtt ttcctctgaa acatgtctgt tacccctctc 2489 catcttacca agttgaaaag gggaatattt ggccacatac ccctctggtt ttcgtaggtt 2549 cttttggttc agaatattgt ttgtgccagt acatgacctt aacttccttc ctcagagcac 2609 tgagctgcca tctgggctat tctggggtaa aaggaaggct gggagtggtg ggaattttat 2669 aaatatttat tctcttttct ttgtttcata ggagtcttgt gttatacaag gttagtcctt 2729 catggtataa tcttactgat gcactgggcc tatctttttg ttttccagcc agttgaatag 2789 attagttttt ctcagtaact tactatccag cagactggct ttcctgagac ttgaggttgt 2849 ggcttatact ggaatgagac cactgtacgt gtaggtggtt cagatcctgc gtaatggcag 2909 catgaggact taaaaggtgg ttttcatttt gaagatggct atgtagcttg taaggtgtat 2969 cacagcagta cctctcatgg ctttttggtt ccagcagtga gggcattggt gagatcaatg 3029 gtaaactgtg caagctttct ttttatcatt aggaaatgtg aaacgttgga caaattttga 3089 gttttaacaa ggacaaaaag ttgaaagaaa aggcacagtt aacaaaaaag ggtggctaga 3149 tttatcttgg gtgatggagg aaatga gaga ggaatgctct tgaaaggtgg tctgtggatc 3209 tgtctgaata gaaagagcac agtaagtatg cattgccgga gaaaacgtcc ttgaagctgc 3269 ttgtctcatg tgtatgatgt gctttttaaa tcatgcccct cgttgcctgc ctaatctgtg 3329 actccctaaa aactaactgg gcccatgtag atggggctgc aaccagagct gaataacatg 3389 ttaggctcac acatgcatca gcactgcaca ctggaatcat tgctcttcct ggactttgta 3449 gaaatcagtc tcaagtgctt caagagtctg gctcctgcta cttttatctg tcaggtagca 3509 cataaggttt gcagggttta tattttgtat agaatcacag ttgtggagaa aaagtaataa 3569 tttctcaatg aattttaaaa atgggcctat tttctatccc cgtggttcat ctgatataat 3629 tagtgttccc tgtgaattcc ccccctctat gggaaggatg cctttactct ttatcagtaa 3689 taaattatga ctgttttcat attgccttag ggttatttcc ctgtgtaaac cattgtcttt 3749 tgttttggtt ttctttagca ttatgaagct ttggtattgt acaaggtcag tagtaagatg 3809 ctcactagtc tcagggcttg tgtaatattc tgggaggtca tttaaatgcc agaaatggtc 3869 aagcaattat acacagtatt tatgactctg ttaagcatac cgtttgtctg tcacattagt 3929 agattctgag attaaaaaaa atttttaaag agtgatcatt taaataattt ctaaaagggt 3989 cttttcaagc tctaacaaag tcactaacaa a tgcattatt ttctacagaa ttagatgtta 4049 gtagtacagt actgcatatt cagggaaaaa gtgtgaggaa ttgatttcaa aatagttcgt 4109 tcttgtgttt gacctaagaa tgattgtcgc atgaagtgtt tgtttttaca gtttagcata 4169 tataaacaaa catgatagga ttccttaaga tgttaccacc cagggggcca caagccagcc 4229 tgctgtctca ggaagctgta gaaggagtgt ttgtcaattt cttgtcactg gtttgctgac 4289 ttactgagga ttaattgttg ccttacaatg ttactgaaat aaactgttta atat 4343 <210> 63 <211> 4292 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1283) .. (1831) <400> 63 cgccctgacc acacaggctg cctacgagct gcacgtggac ctggaggact ttgagaatgg 60 cacggcctat gcccgctacg ggagcttcgg cgtgggcttg ttctccgtgg accctgagga 120 agacgggtac ccgctcaccg tggctgacta ttccggcact gcaggcgact ccctcctgaa 180 gcacagcggc atgaggttca ccaccaagga ccgtgacagc gaccattcag agaacaactg 240 tgccgccttc taccgcggtg cctggtggta ccgcaactgc cacacgtcca acctcaatgg 300 gcagtacctg cgcggtgcgc acgcctccta tgccgacggc gtggagtggt cctcctggac 360 cggctggcag tactcactca agttctctga gatgaagatc cggccggtcc gggaggaccg 420 ctagactggt gcaccttgtc cttggccctg ctggtccctg tcgccccatc cccgacccca 480 cctcactctt tcgtgaatgt tctccaccca cctgtgcctg gcggacccac tctccagtag 540 ggaggggccg ggccatccct gacacgaagc tccctgggcc ggtgaagtca cacatcgcct 600 tctcgccgtc cccaccccct ccatttggca gctcactgat ctcttgcctc tgctgatggg 660 ggctggcaaa cttgacgacc ccaactcctg cctgccccca ctgtgactcc ggtgctgttt 720 gccgtcccct ggccaggatg gtggagtctg ccccaggcac cctctgccct gcccggccaa 780 atacccggca ttatggggac agagagcagg gggcagacag cacccctgga gtcctcctag 840 cagatcgtgg g gaacgtcag gtctctctga ggtcaggtct gaggccagta tcctccagcc 900 ctcccaatgc caacccccac cccgtttccc tggtgcccag agaacccacc tctcccccaa 960 gggcctcagc ctggctgtgg gctgggtggc cccatcctac caggccctga ggtcaggatg 1020 gggagctgct gcctttgggg acccacgctc caaggctgag accagttccc tggaggccac 1080 ccaccctgtg ccccggcagg cctggggtct gcagtcctct tacctgctgt gcccacctgc 1140 tctctgtctc aaatgaggcc caacccatcc cccacccagc tcccggccgt cctcctacct 1200 ggggcagctg gggctgccat cccatttctc ctgcctctgg aaggtgggtg gggccctgca 1260 ccgtggggct ggactgcgct aa tgg gaa gct ctt ggt ttt ctg ggc tgg ggc 1312 Trp Glu Ala Leu Gly Phe Leu Gly Trp Gly 1 5 10 cta ggc agg gct ggg atg agg ctt gta caa ccc cca cca cca att tcc 1360 Leu Gly Arg Ala Gly Val Gln Pro Pro Pro Pro Ile Ser 15 20 25 cag gga ctc cag ggt cct gag gcc tcc cag gag ggc ctt ggg ggt gat 1408 Gln Gly Leu Gln Gly Pro Glu Ala Ser Gln Glu Gly Leu Gly Gly Asp 30 35 40 gac ccc ttc cct gag gtg gct gtc tcc atg agg agg cca acc ctt gcc 1456 Asp Pro Phe Pro Glu Val Ala Val Ser Met Arg Arg Pro Thr Leu Ala 45 50 55 att gac cgt ggc cac ctg gac cca ggc cag gcc cgg ccc ggc gag tgg 1504 Ile Asp Arg Gly His Leu Asp Pro Gly Gln Ala Arg Pro Gly Glu Trp 60 65 70 tca agg gac agg gac cac ctc acc ggg caa atg ggg tcg ggg gga ctg 1552 Ser Arg Asp Arg Asp His Leu Thr Gly Gln Met Gly Ser Gly Gly Leu 75 80 85 90 ggg cac cag acc agg cac cac ctg gac act ttc ttg ttg aat cct ccc 1600 Gly His Gln Thr Arg His His Leu Asp Thr Phe Leu Leu Asn Pro Pro 95 100 105 aac acc cag cac gct gtc atc ccc act cct tgt gtg cac aca tgc aga 1648 Asn Thr Gln His Ala Val Ile Pro Thr Pro Cys Val His Thr Cys Arg 110 115 120 ggt gag acc cgc agg ctc cca gga cca gca gcc aca agg gca ggg ctg 1696 Gly Glu Thr Arg Arg Leu Pro Gly Pro Ala Ala Thr Arg Ala Gly Leu 125 130 135 gag ccg ggt cct cag ctg tct gct cag cag ccc tgg acc cgc gtg cgt 1744 Glu Pro Gly Pro Gln Leu Ser Ala Gln Gln Pro Trp Thr Arg Val Arg 140 145 150 tac gtc agg ccc aga tgc agg gcg gct ttt cca agg cct cct gat ggg 1792 Tyr Val Arg Pro Arg Cys Arg Ala Ala Phe Pro Arg Pro Pro Asp Gly 155 160 165 170 ggc ctc cga aag ggc tgg agt cag cct tgg gga gct gcc tagcagcctc 1841 Gly Leu Arg Lys Gly Trp Ser Gln Pro Trp Gly Ala Ala 175 180 tcctcgggca ggaggcctgcctgcctgcctggtcctgcctgcc cactgaagtt tgtgcttaaa aaacaataaa 1961 tttgacttgg caccactggg ggttggtggg agaggccgtg tgacctggct ctctgtccca 2021 gtgccaccag gtcatccaca tgcgcagatg tctgcagcgc ttccttctgc cgtgggccca 2081 ggctggacag gacctggtcc ctgccctctc ggtcctcagc tggacgcaga tacagccaag 2141 aatcaggcag tggcagccta gtgtggccgg ggtggtggct ggagcaggcc aggtgcgggg 2201 ccacaagggg caagatgtgg gcaaaatgac cacatgagat tcaacgggaa atcccttctt 2261 ggctcctctt cccaccatct agaagccaag ggagcccacc cagaccatct gggttcccag 2321 agcaccctgt catattgcag gggctgggtg ggacccgagt tctcatccca ggagcccccc 2381 accgacaggc cccaggcagg agctaccagc ctccccatgc cagtgactgc gccagcgact 2441 gcttagaaag tgccagcact ttctgatgtg tcatcaaaca aactcctggt gagtgtgaag gaggacct gaggacct gaggacct ctcg tgccagggct 2561 tggctgtgga acagatgcac catggctggg gcctggcgag gggccggggg caggtgcagg 2621 tggcctgtga gcctgtggtc caggtccagg tcccggcagc atctgtcctc agtggctggc 2681 tgcactgggg atgcctgtcc cttctagagc cctgttactg ccctagagca ccggcccctg 2741 tcccagacca ggagagggca catggcccta ccaagcaccg gctgaatggg cacggagctt 2801 gacatggtgg ggagggccca ggccagcgca ccggccccac cctccccagg ggcaccttca 2861 aaggctggca ctggggaaaa acggtccctg cgcacctgct ccgggccaca ccctctcacc 2921 ctagccctgc agagcctacg gtctgatacc agtgcaaatg gctctcatct gagacaggag 2981 gatggggatg ctgggagagc cctgggcgag ggacagctcg agacctgtgg gctgagtgac 3041 caggccaagg gctagcatgt gcacagggtc gcctgggacc cacgggcccc aaaccgtccc 3101 ctgggaccca gtttgagggt ggatgcctgc agccctccat cccacaatgc cacctgactg 3161 agcctcctcc tgctgcttca cttgagggga gtaagctgag tgggaggggt ctctgcatcg 3221 ccacactggg acctggaggc agcgcacctg cgccgttgct tctccacgtg cacaggtagg 3281 ttttgtggct cagccagtgg ccttcctcct ttcccctaaa cttcacacat atctcagaga 3341 gttacaccaa aggccacgca gctgactgcc tgagcaccaa ggtccagagg a tggaaggaa 3401 ccttggtttc catgctggtg gcctcagcac attcagctgg agaacagcaa aggaacagag 3461 ctgtgagcca ttctcaaaca gctttcccct gcagctgcgt gtaaattggt tttataatgt 3521 ttgtctttgg gacaaaagct gtatcgccag tgcctacctc cttctggtgc ccctaaccct 3581 tcctgccacc tgtcctcgtc cacacaggcc tctggctggc ttggctgggg ccagagccct 3641 ggaagctggg agccagggtc tctggaggcc ctgtcaccca ggggcgtgtc tgagcaggca 3701 gagatttgga ggattgttga accatctcaa accatgagga cgctggctcc agggagggga 3761 aggaagagga gaggtaccgt ttgtgtgaga tggggggacg ggacataaag aacgcctgtg 3821 gccagcggca gacccgtcct gtgacttcag gagcaatgta ccggcaggag gacccagcag 3881 gggacacaca gaacccagaa caaggagaca ggacactaag ctttggcctc agcggaccgg 3941 gcttccccag ggcctccatt tcttcatctg ctttcagaga caaggatgtc cccaaactgt 4001 gtggcccaag cagccggcag gacttggcaa acccagaggg ctgaggtcgg gcctcggtgg 4061 gatttgtagg gagtgttggg agctctggct caaggctggc cacgttggcc cctcatgcgc 4121 tgacaggtgt gtctgactcg ggccacacag cactggccag ggctgcagag ggagctcaga 4181 gggccagcac agcgactggt ggaggaagcc tggtatggga gcatcgctag gcgagg ctgt 4241 cagcacttgg tgtctgtgcg ttctgtcttt aataaagtct catggtgacc c 4292

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Daisuke Nakajima 1532-3 Yana, Kisarazu-shi, Chiba F-term in Kazusa DeNA Research Laboratory (reference) 4B024 AA01 AA11 BA21 BA80 CA04 DA06 EA04 GA11 GA18 GA19 HA03 HA14 4H045 AA10 BA10 CA40 DA01 EA21 EA50 FA74

Claims (5)

[Claims] 1. A DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) SEQ ID NO:
1 to 63 (however, SEQ ID NOs: 4, 6, 11, 14, 1
(Excluding 7, 18, 26, 52, 54, 57 and 60)
A polypeptide consisting of an amino acid sequence identical or substantially identical to the amino acid sequence shown in any one of (b);
SEQ ID NOs: 1 to 63 (provided that SEQ ID NOs: 4, 6, 11,
14, 17, 18, 26, 52, 54, 57, and 60
In the amino acid sequence represented by any one of (a) to (b), wherein the amino acid sequence is composed of an amino acid sequence in which some amino acids have been deleted, substituted or added, and which has substantially the same function as the polypeptide of (a). A polypeptide having activity. 2. The DNA of the following (a) or (b):
(A) SEQ ID NOs: 1 to 63 (provided that SEQ ID NOs: 4, 6,
11, 14, 17, 18, 18, 26, 52, 54, 57, and 60), a DNA comprising a base sequence encoding an amino acid sequence represented by each of the base sequences; (b) DNA that hybridizes with the DNA of (a) under stringent conditions and encodes a protein having substantially the same biological activity as the function of the polypeptide of (a). A gene comprising the human DNA according to claim 1 or 2. 4. A recombinant polypeptide of the following (a) or (b): (a) SEQ ID NO: 1 to 63 (provided that SEQ ID NOs: 4, 6, 11, 14, 17, 18, 26, 52, 54,
A polypeptide consisting of an amino acid sequence identical or substantially identical to the amino acid sequence represented by any one of SEQ ID NOs: 1 to 63 (excluding 57 and 60);
SEQ ID NOs: 4, 6, 11, 14, 17, 18, 26, 5
2, 54, 57 and 60) in the amino acid sequence represented by any one of
A polypeptide consisting of a substituted or added amino acid sequence and having substantially the same biological activity as the function of the polypeptide of (a). A recombinant protein encoded by the gene according to claim 3.