JP2002226353A - Cosmetic containing sphingoglycolipid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a cosmetic containing, in a high concentration, a sphingoglycolipid considered to play an important role in moisture retention by using, as a raw material, a by-product derived from potatoes which are scarcely utilized as a food. SOLUTION: This cosmetic is characterized by including a sphingoglycolipid derived from potatoes. A method for producing the cosmetic containing the sphingoglycolipid derived from the potatoes is characterized by adding an organic solvent to the potatoes and extracting the sphingoglycolipid with the solvent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to cosmetics containing glycosphingolipids extracted from potatoes and a method for producing the same.

[0002]

2. Description of the Related Art Recent studies have revealed that some complex lipids, especially glycolipids, have remarkable physiological activities. For example, ceramides composed of fatty acids and sphingosine and cerebrosides composed of sugars, fatty acids and sphingosine are found to be abundant in the stratum corneum of human skin, and have a function of preventing evaporation of water from the body. This glycosphingolipid penetrates into the stratum corneum by being applied to the skin, enhancing the moisturizing effect of the skin,
It has been found that it is effective in improving rough skin, wrinkles and atopic dermatitis. Therefore, application to the beauty field utilizing this high moisturizing property, and further application to the pharmaceutical field utilizing the elastase inhibitory effect and free radical inhibitory effect are progressing.

Conventionally, these ceramide-related substances, mainly glycosphingolipids, have been extracted from cattle brain and supplied. However, animal-derived glycosphingolipids have a problem of possible virus infection. In particular, since the occurrence of mad cow disease in 1986, the supply of human glycosphingolipids has dropped sharply due to the possibility of human infection. In some cases, a chemically synthesized ceramide-like compound is used, but the synthesis is costly and has no effect comparable to that of a natural product.

[0004] Recently, it has been found that a plant-derived ceramide-related substance is as effective as an animal-derived substance and has no side effects or toxicity. Therefore, studies on extracting a ceramide-related substance from a plant material have been actively conducted. ing. Up to now, plant-derived glycosphingolipids, particularly glycosylceramide among them, include rice (Agric. Biol. Chem., 49, 27).
53 (1985)) and rice bran (JP-A-62-1874).
04, JP-A-11-279586), wheat (Agric. Biol. Chem., 49, 3609 (1985),
Japanese Unexamined Patent Publication No. Hei 6-507765, soybean (Chem. Pharm.
Bull., 38 (11), 2933 (1990) and JP-A-7-2683) are known.

[0005]

However, as a plant raw material for obtaining a plant-derived glycosphingolipid, so far, cereals and beans have been limited. The content of these glycosphingolipids is not so large, and all are about 0.01% by mass. Moreover, all of these plant raw materials are edible by human beings, and residues after extraction of glycosphingolipids lose their value as foods. As described above, it is a problem of plant raw materials that a very large number of food raw materials lose their value as foods because a very small amount of glycosphingolipid components are extracted.

An object of the present invention is to provide a cosmetic product containing a high concentration of glycosphingolipid, which is considered to play an important role in moisturizing, by using by-products derived from potatoes which are not used as food at all. The purpose is.

[0007]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that glycosphingolipids are contained in potatoes at a concentration comparable to or surpassing that of cereals and beans. It was also found that this glycosphingolipid can be extracted with an organic solvent and that it can be used as a raw material for cosmetics after a certain degree of purification. Moreover,
The present inventors have found that by blending this glycosphingolipid in cosmetics and using it continuously, it has a remarkable effect on the moisturizing effect of the skin and the improvement of the rough skin, and reached the present invention.

[0008] That is, the first aspect of the present invention is a gist of cosmetics characterized by containing glycosphingolipids derived from potatoes, and the potatoes are preferably konjac potatoes. The second aspect of the present invention is to provide a method for producing a glycosphingolipid-containing cosmetic product, which comprises adding an organic solvent to potatoes and extracting the glycosphingolipid.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. The potatoes used as the extraction raw material in the present invention may be sweet potato, potato, taro, yam, konjac potato, yam, etc., may be used as it is, or may be processed by operations such as drying, grinding and heating. . Among these, preferred examples include konjac potato, which is preferably discarded in a large amount and is preferably used because it can be obtained at low cost. Konjac Tobi powder is made from konjac potato as a raw material by-product during the production of konjac 3,000-400 per year
Despite the generation of 0 tons, it has a unique astringent taste and pungent odor, so it is used as a thickener for some fertilizers, concrete, etc., but is not used as food at all.

The cosmetics referred to in the present invention are permeated from the skin or hair by prescribing from the outside of the body, moisturizing skin effect, whitening effect, wrinkles, spots, freckles, improvement of rough skin, hair restoration, hair growth, branching. It is effective for one or more selected from hair prevention, atopic dermatitis, allergic dermatitis, pimples, xerosis and the like. The prescription is
The glycosphingolipid of the present invention may be used alone or mixed with other cosmetic ingredients. The form of the prescription is not limited, and lotion, milky lotion, moisture cream, sunscreen, tanning cosmetics, pack, foundation, toy, blusher, eye makeup, perfume,
It may be applied to the skin as a cologne, lip balm, lipstick or the like, or may be applied to the hair as a hair tonic, hair restorer, pomade, set lotion, hair spray, hair dye, hair tonic, eyelash cosmetic. It may also be formulated by adding it to a facial cleanser, facial cleanser soap, shampoo, rinse, treatment, or even a bath agent.

As the organic solvent used as the extraction solvent in the present invention, any organic solvent can be used as long as it reacts with the raw materials and the glycosphingolipids during the extraction and does not impair the effects of the present invention. Further, one kind of solvent may be used alone, or a plurality of solvents may be mixed and used. Examples of such organic solvents include alcohols such as methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol and tert-butanol, hexane, pentane, diethyl ether, chloroform, dichloromethane, acetone, acetonitrile, Ethyl acetate and the like can be mentioned. Preferred examples among these are:
Examples include methanol, ethanol, hexane, and acetone, and particularly preferred examples include ethanol and acetone. When extracting with these organic solvents, additives such as water and a surfactant can be added in order to increase the extraction efficiency as long as the effects of the present invention are not impaired.

The amount of the organic solvent used for the extraction is preferably about 1 to 30 times, more preferably about 1 to 10 times the amount of the potatoes as the raw material. If the amount of the solvent used is below this range, the solvent may not be distributed throughout the raw material, and extraction may be insufficient.Addition of the solvent exceeding this range no longer affects the amount of extraction, This only increases the burden of the solvent removal work in the subsequent concentration step.

The extraction temperature depends on the boiling point of the solvent used, but is preferably in the range of 0 ° C. to 80 ° C., more preferably in the range of about room temperature to 60 ° C. If the extraction temperature is lower than this range, the extraction efficiency decreases, and if the temperature is higher than this range, the extraction efficiency is not significantly affected, and the energy consumption is increased unnecessarily.

The extraction time is 1 to 48 hours, preferably 2 hours.
~ 20 hours. If the extraction time is shorter than this range, the extraction is not sufficiently performed, and even if the extraction is performed for a long time that exceeds this range, an increase in the amount of extraction can no longer be expected.

The extraction operation is not limited to a single batch operation. A fresh solvent can be added again to the residue after the extraction to perform the extraction operation, or the extraction solvent can be brought into contact with the extraction raw material a plurality of times. That is, as the extraction operation, any of a batch operation, a semi-continuous operation, and a countercurrent multi-stage contact operation can be used. Further, a known extraction method such as Soxhlet extraction may be used.

Next, the extraction residue is separated and removed. The method of separation is not particularly limited, and known methods such as suction filtration, filter press, cylinder press, decanter, centrifuge, and filtration centrifuge can be used.

The extract thus obtained is sent to a concentration step. The method of concentration is not particularly limited, and the concentration can be carried out, for example, by a reduced-pressure concentration device such as an evaporator or by removing the solvent by heating.

The above concentrate can be used as it is,
Subsequently, when it is necessary to remove impurities and further improve the purity, purification by a conventional method is possible. For example, washing with water, washing with hexane, a method of passing through a silica gel column, a resin column, a reversed phase column, or the like, a distribution with a solvent having a different polarity, a recrystallization method, and the like can be mentioned. If it is necessary to obtain particularly high glycosphingolipid, after treatment with an alkaline solution, partition with chloroform, diethyl ether, etc., separate and concentrate the organic layer, and further concentrate it on silica gel column chromatography. Preferably, the lipids are separated.

Next, an analysis method of the obtained glycosphingolipid-containing mixture is described. The simplest analysis method is a thin layer chromatography method. Glycosphingolipids,
Among them, glucosylceramide is commercially available, so using this as a standard, using a silica gel thin layer plate and developing using an appropriate solvent system such as chloroform-methanol system,
Analysis can be easily performed by coloring with concentrated sulfuric acid or anthrone reagent. In addition, the analysis can be performed by a known method such as a high performance liquid chromatography method or various chromatograph-mass spectrometry methods.

The glycosphingolipid-containing substance obtained as described above can be used as it is as the cosmetic of the present invention, but if it is dissolved in an organic solvent such as ethanol or dispersed in water, handling becomes easier.

In the ethanol solution, since the glycosphingolipid-containing substance is soluble in ethanol, it may be dissolved in ethanol as it is. In order to prevent the purification and suspension of the precipitate, a stabilizer can be added as long as the effect of the present invention is not impaired.

In order to produce the aqueous dispersion, the glycosphingolipid-containing substance may be introduced into a predetermined amount of water and stirred, or may be heated or subjected to ultrasonic treatment as long as the effects of the present invention are not impaired. Alternatively, dispersion may be promoted by adding a conventionally known emulsifier or dispersant.

In the cosmetic of the present invention, vitamins, collagen, squalane, soy lecithin,
Plant-derived sterols, hyaluronic acid, sorbitol,
Chitin, chitosan, glycerin, butylene glycol,
Propylene glycol, niacinamide and the like can also be added.

The cosmetics of the present invention are highly safe because they contain glycosphingolipids derived from potatoes, and the content of glycosphingolipids is not particularly limited. The preferable content of glycosphingolipids derived from potatoes is 0.001% by mass to 100% by mass. If the content is less than this, the onset of the effects of the present invention tends to be slow or reduced.

The effects of using the cosmetic of the present invention include moisturizing the skin, improving skin roughness, and whitening effect. Regarding the moisturizing of the skin, the effect can be known by using a conventionally known measuring method such as measurement of transepidermal water loss (TEWL) and measurement of keratin water content. For example, to measure TEWL
Evaporimeter (Servo Med Sweden), Tewameter
(Courage + Khazaka Germany) can be used. For measuring the amount of keratin water, for example, Corneometer (Co
urage + Khazaka GmbH, Germany), Skikon-200
(S Co., Ltd.) can be used. About the improvement of rough skin, the effect can be known visually and by the sense of the person concerned. The effect of the whitening effect can also be seen visually, but the Megzameter MX16 (Courage + Khazaka
It can also be quantitatively measured using a skin color measuring device such as a German company.

The effect of applying the cosmetic of the present invention to the skin is as follows. Glycosphingolipids contained in potatoes have a specific effect on the skin, resulting in, especially, rough skin, atopic dermatitis, allergic dermatitis, pimples It is superior to wheat, rice bran, and soybeans, which are conventionally known plant materials, in improving the quality.

[0027]

EXAMPLES The present invention will be described below in detail with reference to examples, but the present invention is not limited to these examples. First,
The measuring device and measuring method used in the following examples will be described.

(1) Glycosphingolipid qualitative method The silica gel thin-layer chromatography (TLC) was used for the qualification of glycosphingolipids. A predetermined amount of a sample is applied to a silica gel plate (Silicagel 60F254 type, manufactured by Merck,
(Thickness: 0.5 mm), and introduced into a developing tank of chloroform: methanol: water = 87: 13: 2 (volume ratio) and developed. After the development, the silica gel plate was dried with a drier or the like, and the color was developed by spraying with sulfuric acid and heating.

(2) Glycosphingolipid Quantitative Method High-performance liquid chromatography (HPLC) was used for the quantification of glycosphingolipids. Using Waters LC Module 1,
The column used was GL Science's Inertsil SIL 100A. Solvent: chloroform: methanol = 9: 1 (volume ratio)
At 25 ° C. at a flow rate of 1.0 ml / min. A light scattering detector (500 ELSD manufactured by ALLTECH) was used for detection.

(3) Measurement method of keratin water content Kerage water content is measured by Courage + Khazaka Corneometer
Measurements were taken at the same location inside the upper arm every time using CM825. The measurement was performed 10 times per person, and the average was taken as the data of that person, and expressed as the average value of all the subjects.

Example 1 1 kg of konjac flying powder was charged into a stirring tank, 2 L of ethanol was added thereto, and the mixture was stirred at room temperature for 2 hours. Thereafter, the extract and the residue were separated by filtration. The extract was concentrated by an evaporator to obtain 10.7 g of a brown waxy concentrate. When this was measured based on the qualitative and quantitative methods described above, a spot of glycosphingolipid was detected by TLC, and it was found by HPLC that 0.55 g of glycosphingolipid was contained. The purity of the glycosphingolipid in the flying powder extract was 5.1% by mass.

Next, 10.0 g of the obtained waxy concentrate was added to 2
It was dissolved in 0.0 g of ethanol, introduced into 200 g of water with stirring, and stirred as it was in a dispersed state. After 30 minutes, 5.0 g of sodium chloride was introduced, and 10 g of sodium chloride was added.
After stirring for minutes, a brown precipitate was obtained.
The weight of this precipitate was 6.8 g, and the content of glycosphingolipid measured by HPLC was 0.45 g. The purity of the glycosphingolipid in the extract after the washing operation was 6.6.
% By mass. When this washing operation was repeated once more, the weight of the precipitate was 6.4 g, and the content of glycosphingolipid measured by HPLC was 0.44 g.
The purity of glycosphingolipid after two washing operations was improved to 6.9% by mass.

A column was filled with 150 ml of silica gel (silica gel 60, 70-230 mesh, manufactured by Nacalai Tesque), and 200 ml of a mixed solvent of ethyl acetate: methanol = 9: 1.
Shed. When the liquid level of the solvent reached the upper end of the silica gel and the outflow became slow, 1.9 g of the precipitate obtained above was dissolved in hexane to make 6.0 ml and introduced. Then, a mixed solvent of ethyl acetate: methanol = 9: 1 400
and the effluent was collected in 20 ml increments. As a result of analyzing the collected effluent by thin-layer chromatography, spots of glycosphingolipids were found in the twelfth to seventeenth collected liquids counted from the beginning. When the effluent in this range was collected and the solvent was distilled off, 386 mg of a solid content was obtained. The content of this glycosphingolipid was determined by HPLC to be 226 mg, and the glycosphingolipid concentration in the obtained glycosphingolipid-containing substance was 58.5% by mass.

Next, silica gel (silica gel 60, 70-230 mesh, manufactured by Nacalai Tesque) was applied to the column.
0 ml was charged and 200 ml of a mixed solvent of ethyl acetate: methanol = 95: 5 was flowed. When the liquid level of the solvent reached the upper end of the silica gel and the outflow became slow, a solution obtained by dissolving 386 mg of the solid content obtained by the above silica gel column in a small amount of hexane was introduced. Then, ethyl acetate:
800 ml of a mixed solvent of methanol = 95: 5 was flowed, and an effluent was collected in 20 ml portions. As a result of analyzing the collected effluent by thin-layer chromatography, spots of glycosphingolipids were solely observed in the 20th to 26th collected liquids counted from the beginning. When the effluent in this range was collected and the solvent was distilled off, 87 mg of a solid was obtained. The content of this glycosphingolipid was determined by HPLC to be 86 mg, and the glycosphingolipid concentration in the obtained glycosphingolipid-containing substance was 98.9% by mass.

The obtained solid content (50.6 mg) was introduced into 10 ml of water while stirring, and BRANSON3200 manufactured by Yamato Scientific was introduced.
For 30 minutes by ultrasonic wave. Thus, a cosmetic product containing the glycosphingolipid derived from konjac flour of the present invention was obtained. The obtained glycosphingolipid-containing aqueous dispersion was uniform, and no precipitation occurred even after one day. In other words, 50 mg of glycosphingolipid derived from konjac flying powder is contained in this aqueous dispersion.

Example 2 1 kg of potato skin crushed to 100 μm or less was charged into a stirring tank, and 2 L of ethanol was added thereto.
Stirred for hours. Thereafter, the extract and the residue were separated by filtration. The extract was concentrated by an evaporator to obtain 10.2 g of a yellow waxy concentrate. When this was measured based on the qualitative and quantitative methods described above, spots of glycosphingolipid were found by TLC, the glycosphingolipid quantified by HPLC was 0.42 g, and the purity in the potato skin extract was 4. It was 1% by mass.

5 g of the obtained potato skin extract was added to 10.0 g
g of ethanol, and introduced into 100 g of water with stirring, followed by stirring in a dispersed state. After a lapse of 30 minutes, 2.5 g of sodium chloride was introduced, and the mixture was further stirred for 10 minutes to obtain a light brown precipitate. The weight of this precipitate was 3.0 g, and the content of glycosphingolipid measured by HPLC was 0.18 g. The purity of the glycosphingolipid in the extract after the washing operation was 6.0% by mass. When this washing operation was repeated once more, the weight of the precipitate was 2.8 g, and the content of glycosphingolipid measured by HPLC was 0.18 g. The purity of glycosphingolipid after two washing operations was 6.4% by mass. The thus obtained potato skin-derived glycosphingolipid-containing material was purified by silica gel column chromatography twice in the same manner as in Example 1,
38 mg of glycosphingolipid-containing material containing 96.8% by mass of glycosphingolipid was obtained.

The above operation was repeated several times, and 51.7 mg of a glycosphingolipid-containing substance derived from potato skin was introduced into 10 ml of water with stirring, and BRANSON manufactured by Yamato Scientific was introduced.
Dispersion treatment was carried out by ultrasonic wave using a 3200 for 30 minutes. Thus, a cosmetic product containing the glycosphingolipids derived from potato skin of the present invention was obtained. The obtained glycosphingolipid-containing aqueous dispersion was uniform, and no precipitation occurred even after one day. That is, this aqueous dispersion contains 50 mg of glycosphingolipid derived from potato skin.

Comparative Example 1 1 kg of flour was charged into a stirring tank, 2 L of ethanol was added thereto, and the mixture was stirred at room temperature for 2 hours. Thereafter, the extract and the residue were separated by filtration. The extract was concentrated by an evaporator to obtain 6.8 g of a brown waxy concentrate. When this was measured based on the qualitative and quantitative methods described above, the glycosphingolipid spot confirmed by TLC was thin, and the glycosphingolipid quantified by HPLC was 0.05 g,
The purity in the flour extract was as low as 0.7% by mass.

5 g of the obtained flour extract was dissolved in 10.0 g of ethanol, introduced into 100 g of water with stirring, and stirred as it was in a dispersed state. After 30 minutes,
By introducing 2.5 g of sodium chloride and further stirring for 10 minutes, a brown precipitate was obtained. The weight of this precipitate was 3.6 g, and the content of glycosphingolipid measured by HPLC was 0.04 g. The purity of the glycosphingolipid in the extract after the washing operation was 1.1% by mass. When this washing operation was repeated once more, the weight of the precipitate was 3.4 g, and the content of glycosphingolipid measured by HPLC was 0.04 g. The purity of glycosphingolipid after two washing operations was 1.2% by mass.
The thus obtained wheat-derived glycosphingolipid-containing material was purified by silica gel column chromatography twice in the same manner as in Example 1 to obtain a glycosphingolipid containing 97.5% by mass of glycosphingolipid. Include 2
mg was obtained.

The above operation was repeated several times, and 51.3 mg of a wheat-derived glycosphingolipid-containing substance produced was added to 10 ml of water.
Branson 320 made by Yamato Scientific
Dispersion treatment was carried out for 30 minutes by ultrasonic using 0. The obtained glycosphingolipid-containing aqueous dispersion was uniform, and no precipitation occurred even after one day. That is, this aqueous dispersion contains 50 mg of glycosphingolipid derived from wheat.

Comparative Example 2 1 kg of defatted rice bran was charged into a stirring tank, and ethanol 3 was added thereto.
L was added and stirred at room temperature for 2 hours. Thereafter, the extract and the residue were separated by filtration. The extract was concentrated by an evaporator to obtain 22.3 g of a brownish waxy concentrate. This was measured based on the qualitative and quantitative methods described above. Glycosphingolipid spots confirmed by TLC were light, and spots of glyceroglycolipids, sterols, etc. developed dark. Glycosphingolipid quantified by HPLC was 0.38
g, and the purity in the defatted rice bran extract was as low as 1.7% by mass.

10 g of the defatted rice bran extract was added to 20.0 g
g of ethanol, introduced into 200 g of water with stirring, and stirred in a dispersed state. After a lapse of 30 minutes, 5.0 g of sodium chloride was introduced, and the mixture was further stirred for 10 minutes to obtain a brown precipitate. The weight of this precipitate was 7.4 g, and the content of glycosphingolipid measured by HPLC was 0.24 g. The purity of the glycosphingolipid in the extract after the washing operation is 3.2% by mass.
Met. When this washing operation was repeated once more, the weight of the precipitate was 6.9 g, and the content of glycosphingolipid measured by HPLC was 0.22 g. The purity of glycosphingolipid after two washing operations was 3.2% by mass. The thus obtained rice bran-derived glycosphingolipid-containing substance was purified by silica gel column chromatography twice in the same manner as in Example 1 to obtain a glycosphingolipid containing 98.2% by mass of glycosphingolipid. 28 mg of the product were obtained.

The above procedure was repeated several times, and 50.9 mg of a rice bran-derived glycosphingolipid-derived material was added to 10 m of water.
l with stirring, and Yamato Scientific BRANSON32
The dispersion treatment was carried out for 30 minutes by ultrasonic wave using 00. The obtained glycosphingolipid-containing aqueous dispersion was uniform, and no precipitation occurred even after one day. That is, the aqueous dispersion contains 50 mg of glycosphingolipids derived from rice bran.

Test Example 1 Cosmetic products of the present invention obtained in Examples 1 and 2 and comparative examples were obtained from volunteers of 10 women with dry skin (5 to 20 years old, 5 to 20 years old, 40 to 60 years old). The effects of the aqueous dispersions obtained in Examples 1 and 2 on the keratin water content of the skin were examined. 0.5 ml of each aqueous dispersion was applied to the inner side of the left upper arm every day for 30 days.
Corneomete 0 days later,
Table 1 shows the results measured using r, together with the uncoated control.
Shown in

[0046]

[Table 1]

From Table 1, it was found that the application of glycosphingolipids derived from konjac flour powder and skin of potato skin has an excellent effect on improving the keratin water content of the skin.

Example 3, Comparative Example 3 According to the formulation examples shown in Table 2 below, a lotion (Example 3) containing konjac flour-derived glycosphingolipid was prepared. In addition, a lotion (Comparative Example 3) was prepared with the same formulation except that the glycosphingolipid-containing material was removed from this lotion.

[0049]

[Table 2]

Test Example 2 For the lotion obtained in Example 3 and the lotion of Comparative Example 3,
Twenty women were used for two months, and a sensory test was conducted on the feeling of use. Table 3 shows the results. From Table 3, it was found that the lotion containing glycosphingolipids derived from konjac tobi powder had a long lasting moist feeling and also had an excellent effect on flexibility.

[0051]

[Table 3]

[0052]

Industrial Applicability The cosmetics containing glycosphingolipids derived from potatoes of the present invention contain glycosphingolipids present in human skin at a high concentration which is considered to play an important role in moisturizing. It has excellent effects in improving the amount of keratin water in human skin, improving skin roughness, and the like. In addition, by using konjac powder, which is not used as a food at all, as a raw material, it can be easily manufactured at low cost.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Katsuyuki Mukai 23 Uji Kozakura, Uji-shi, Kyoto Unitika F-term in Central Research Laboratories (reference) 4C083 AC102 AC122 AC132 AC302 AC482 AD391 AD392 CC04 DD27 EE12 FF01 FF04 4H059 BA01 BA04 BA12 BA15 BA22 BA30 BA44 BB02 BC14 BC44 CA12 EA13 EA21

Claims (3)

[Claims] 1. A cosmetic product comprising a glycosphingolipid derived from potatoes. 2. The cosmetic according to claim 1, wherein the potatoes are konjac potatoes. 3. The method for producing cosmetics according to claim 1, wherein an organic solvent is added to the potatoes to extract glycosphingolipids.