JP2002029984A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition used for prophylaxis of onset or relief of symptoms in diseases or complaints which occur with aging, more particularly prophylaxis of onset or relief of symptoms in osteoporosis or hypertension of females or men in their forties or over and indefinite complaint syndrome in climateric or mature stage. SOLUTION: This oral composition is characterized by including at least one kind of plant selected from plants of the genus Vitis and Polygonum cuspidatum Sieb. et Zucc. or dried plant thereof or extract thereof and is useful for prophylaxis of onset or relief of symptoms in diseases or complaints which occur with aging.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition useful for preventing the onset of diseases and complaints that occur with aging and for alleviating symptoms. More specifically, it is an oral composition used for the purpose of preventing the onset or alleviating the symptoms of osteoporosis and hypertension in men and women in their forties and menopause / maturity complaint syndrome. It is preferably used for prevention and treatment of indefinite complaint syndrome and indefinite complaint syndrome, osteoporosis and hypertension.

[0002]

BACKGROUND OF THE INVENTION Osteoporosis, hypertension, menopause /
Unidentified complaints of adulthood, hyperlipidemia and the like. Many of these illnesses and complaints develop in middle-aged and elderly
It is known that the time of onset and the degree of symptoms are greatly affected by dietary habits and lifestyle conditions in addition to genetic factors.

[0003] In recent years, in addition to the westernization of food, the use of processed foods, and an increase in opportunities for eating out, there has been a great change in the dietary consciousness itself. As a result, the nutritional intake balance has deteriorated,
People who have been deficient in essential nutrients for a long period of time are becoming prominent, especially in younger generations. In addition, everyday life is also exposed to various types of constant stress, and the onset and progress of the above-mentioned diseases and symptoms are becoming faster than before. This is extremely alarming, given the social phenomena in which the average life expectancy is increasing year by year and the birth rate is falling, and the situation in Japanese society, such as the tightness of medical finances due to the remarkable increase in social health care costs in recent years. It is a situation, and the urgent solution is becoming an important issue.

[0004] To cope with this problem, various medical practices and guidance for improving dietary habits and enlightenment have been made for the purpose of stopping the progress of the disease and alleviating or healing the symptoms. However, these diseases and complaints gradually develop symptoms not only due to the diet and lifestyle described above, but also due to the inevitable phenomenon of aging, a decline in the function of the endocrine and metabolic systems, that is, aging. As the disease progresses, performing its prevention and treatment by medical treatment such as medication increases medical costs and increases the risk of side effects due to long-term medication. In addition, there is a big problem that if medical practice is interrupted, illness and complaint symptoms will progress again because "impaired biological function cannot be fundamentally improved by medical practice".

[0005] On the other hand, with respect to the guidance of improving dietary habits, the improvement effect cannot be obtained when the deterioration of the biological function is caused, and even when the improvement effect can be expected, it is necessary to improve long-term habits and improve the long-term habit. There is a problem that it is difficult to execute for a long period of time, and it is often impossible to execute it, and it is difficult for a person who frequently eats out, such as a company employee, to execute the meal improvement itself.

[0006]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to prevent the onset and alleviation of illnesses and complaints which occur with aging, which are difficult to solve fundamentally.
The present invention provides an oral composition for the purpose of preventing the onset of osteoporosis and hypertension in men and their teens and the symptoms of climacteric / mature indefinite complaint syndrome or alleviating the symptoms.

[0007]

Means for Solving the Problems As a result of intensive studies on physiologically active substances contained in plant components, the present inventors have found that when a grape plant or knotweed is continuously taken,
The present inventors have found that prevention of onset or alleviation of symptoms of osteoporosis, hypertension, and climacteric / mature indefinite complaint syndrome can be expected, and have completed the present invention.

[0008] The present invention has been completed based on such findings, and the merits of this solution are as follows. It is also a supplement to life and can be easily taken, so it is especially effective when it is difficult to improve dietary habits. "," Ingredient that can be expected to improve not only nutritional value but also bioactive function Exists. "

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The grape plant (Vitis) used in the present invention is not particularly limited, but includes European and Middle Eastern varieties of Vinifera species (V. vinifera) and Silbertoris species (V. silvestris). North American varieties of Labrasca (V.labru
sca), California species (V. california), Estivalis species (V. aestivalis), Mansoniana species (V. mansoniana), Linkecummy species (V. lincecumi)
i), vulpina species (V. vulpina), candicans species (V. candicans), cordifolia species (V. cordifo)
lia). Asian varieties of amulensis (V. amurensis), yamagrape (V. coignetia)
e), Korean grape (V. amurensis), shrimp (V. thunbergii), Sankakuzul (V. flexuosa)
Genus (Euvitis) and Mussoniana species (V. munsoniana), and Roton difolia species (V.
rotundifolia) (Muscadinia). Among them, the varieties belonging to the genus Euvitis and the species Rotondifolia (V. rotundifolia),
Vinifera species (V.vinifera), Labruska species (V.labrusc)
a), and varieties bred in Japan mainly using them are preferred.

[0010] More specifically, the species Rotondifolia is Carlos (Carlo).
s), Cobalt (Cowart), Doreen, Fry, Higgins, Hunt, Jumbo, Magnolia, Magnolia, Noble, Scuppernong, Steering (Sterling), Sugargate (Sugargate), Summit (Summit), Tail (Tarheel), Watergate (Watergate), and the like, and Vinifera species (V.
vinifera) include Airen, Aligote, Riesling, Sauvignon blanc, Trebbiano
bbiano), Chardonnay, Chenin blanc, Semillon, Muscat, Cabernet Sauvign
on), Carignan, Cinsau
t), Grenache Noir, Merlot, Mataro, Pinot Noir
Noir), Sangiovese (Sangiovese), Syrah (Sy)
rah), Gamay, Tempranillo
llo), Gewurtraminer, Nebbiolo, Zweigl
trebe), Muller-Thurgau, Grolleau, Cabernet Fran
c), Petit Verdot and the like.

[0011] Also, Vistula labrusca species (V. labru
sca), Zinfandel, and Rotonifolia species (V. rotundifolia): Carlos, Cobalt (Cowart), Doreen (Doree)
n), Fry, Higgins, Hunt (H
unt), Jumbo, Magnolia,
Noble, Scuppernong,
Steering (Sterling), Sugar Gate (Sugargat)
e), Summit, Tail (Tarheel), Watergate (Watergate).

Specific examples of varieties developed in Japan include Ajilondak, Aki Queen, Italy, Izu Nishiki, Olympia, Ohira Della, Kaiji, Cabernet Suntory, Garnet, Kyoho, Campbell Early, King Della, Glow Coleman. , Concord, Koshu, Koshu Sansho,
Suntory Blanc, Suntory Noir, Takao, Delawella, Niagara, Neo Muscat, Honey Seedless, Honey Red, Pione, Hiro Hamburg, Bioveld, Black Queen, Black Hamburg, Brighton, Fuefuki, Fuji Minoru, Hokko, Benizuho, Beniyamabiko , Muscat Hamburg, Muscat Violet, Muscat
Of Alexandria, Muscat Berry A, Yamagrape, Riesling Lion, Rizamart, Ruby Okuyama, Ryuho, Red Queen, Red Pearl, Rosary Bianco and the like.

Particularly preferred grapes are Vinifera species (Vv
inifera) Riesling, Sauvignon blanc, Trebbia
no), Chardonnay, Cabernet Sauvignon, Carignan,
Merlot, Pinot Noir, Syrah, Gamay, Cabernet Franc (Cabern)
et Franc): Zinfandel of V. labrusca species and varieties developed in Japan, Kaiji, Cabernet Suntory, Kyoho, Campbell Early, Koshu, Suntory Blanc, Suntory Noir, Takao, Delawera, Neo Muscat, Pione, Hiro Hamburg, Bio Verd, Black Hamburg, Fuefuki, Fuji Minoru, Beni Ruiho, Beniyamabiko, Muscat Berry A,
Ryuho, Red Queen. Riesling
g), Sauvignon Blanc, Chardonnay, Cabernet Sauvignon (Cabern)
et Sauvignon) Merlot, Pinot Noir
t Noir) Cabernet Franc Kyoho, Concord, Campbell Early, Delawera, Pione,
Koshu, Neo Muscat, Muscat of Alexandria, Glow Coleman, Yama Grape are most preferred.

The site of use of these grapes is not particularly limited, but leaves or fruits (including pericarp and seeds)
Are preferred, and in particular, leaves are most preferred.

The knotweed used in the present invention is a perennial plant belonging to the family Polygonaceae, and includes knotweed, giant knotweed, Meietsutsuso, and knotweed, and knotweed is preferred.

The site of use of the Polygonaceae plant is not particularly limited, but is preferably an above-ground part or a root or rhizome.
Further, roots and rhizomes are most preferred. The plants listed above can be used as they are, or cut, crushed, dried naturally, dried with hot air, freeze-dried, processed by fermentation, or extracted, concentrated, powdered, and granulated according to a conventional method. And the like can be used.

The extraction can be performed by a general extraction method such as an extraction method using an organic solvent or water, a critical extraction method, or the like. As such a method, for example, Japanese Patent Laid-Open No.
For example, a method as described in JP-A-71427 can be mentioned. The extraction solvent is preferably a polar solvent, more preferably alcohols, water and liquefied carbon dioxide, and most preferably ethyl alcohol, water and liquefied carbon dioxide.

The amount of the above-mentioned plants in the composition of the present invention is not particularly limited as long as the desired effects of the present invention can be obtained. It can be appropriately set according to the like, but is 0.0001 to 10% by weight, more preferably 0.001 to 1% by weight, particularly 0.005 to 0.5% by weight in terms of solid content.
Is preferred.

When the composition of the present invention is used for the purpose of prevention or treatment, it can be prepared in various forms such as powders, granules, tablets, capsules and liquids according to a conventional method. The method of ingestion is not particularly limited, and it can be performed by a method according to various forms.

When the composition of the present invention is ingested as a food, it is usually used in various forms such as tablets, lumps, liquids, syrups, capsules, granules, powders, jellies, and pastes. It can be prepared according to the method. Specific examples of such forms include beverages (drinks) such as soft drinks, juices and teas; powdered beverages such as powdered juices, freeze-dried beverages, powdered soups; cookies, biscuits, cereals, chewable tablets, Chewing gum, candy, gummy, wafers, rice crackers and other confectionery; dressings, sauces, seasonings such as powdered seasonings; staple food products such as bread, noodles, rice cakes; foods for the sick, foods for specified health use, nutritional supplements, etc. Functional foods and the like.

Further, the composition of the present invention can be used as a food material (for example, a food additive or the like) that can be used for preparing any food. The composition of the present invention, as long as it does not impair the effects of the present invention, if necessary, usually components used in medicines and foods, for example,
Other medicinal ingredients, micronutrients (vitamins, minerals, etc.), animal and plant ingredients (milk-related ingredients, fats and oils, waxes,
Polysaccharides, amino acids and proteolytic peptides, polyphenols, phospholipids, juices, liquid and solid extracts, etc.), excipients, extenders, sweeteners, flavoring agents, coloring agents, flavorings, foods Fiber, preservative, anionic surfactant,
Nonionic surfactants, cationic surfactants, amphoteric surfactants, alcohols (lower alcohols, higher alcohols, polyhydric alcohols and their ester derivatives, etc.), organic and inorganic acids and their salts, water-soluble polymers, etc. Can be blended. Further, when the plant component to be mixed has an astringent taste, it is preferable to coexist a protein in order to suppress the astringent taste, and it is particularly preferable to mix the protein with milk or dairy products or to add a dairy protein.

The dose and intake of the composition of the present invention are appropriately set depending on the form, age and sex of the patient or the recipient, other conditions, and the degree of the disease, and are divided into once or several times a day. Can be administered or ingested. In particular, when the composition of the present invention is used for the purpose of preventing and treating hypertension and osteoporosis, it is effective to use it for menopause and women after menopause.

When the composition of the present invention is used for the purpose of preventing or treating hypertension or osteoporosis, for example, 30
Applicable to older women. In addition, the oral composition of the present invention having the above-mentioned effects can be ingested as functional foods such as foods for patients and food supplements for specified health use.

[0024]

EXAMPLES Hereinafter, the present invention will be described in more detail based on examples and experimental examples, but the present invention is not limited to these examples. In addition, the numerical value of the compounding amount means "% by weight" unless otherwise specified.

EXPERIMENTAL EXAMPLE 1 Human Drinking Test Ten patients diagnosed with climacteric indefinite complaint syndrome were used as subjects. First, the subjects were asked to fill out a questionnaire shown in the table below. Thereafter, the subjects were randomly divided into two groups, and placebo (A: 250 mg sugar-coated tablet) or the composition of the present invention (B: 250 mg sugar-coated tablet) was administered 4 times a day. The grains were drunk for one month. After drinking,
The same questionnaire was again filled out, and changes in symptoms before and after administration were investigated. During the test period, they performed normal diet and daily life except for drinking test samples, and did not perform any counseling or dietary restrictions. The evaluation was based on the comparison of the total points obtained by adding the answers of each item in the questionnaire and the results of counseling.

[0026]

[0027] * 1: Knotweed (Polygonum cuspidatum Sieb. Et Zuc
After the rhizome and root of c.) were dried and pulverized, water / ethanol = 30/70 (volume ratio) was added thereto, and the mixture was extracted with stirring. After concentrating the extract with a vacuum heating and concentration device, the spray drying device was used. Powdered using.

Questionnaire The following items are evaluated on a 7-point scale (1 when they do not think so, and 7 when they think so). Evaluation items: (1) I often cannot sleep. (2) I often feel depressed. (3) Good dizziness.
(4) The body is often sluggish. (5) I often feel palpitations. (6) The muscles and joints often hurt.
(7) I often feel a hot flash of my body. (8) Sweat often comes out for no reason. (9) It often causes headaches.

As a result of the test, when the score in the questionnaire was evaluated, it was slightly improved (about 8 to 19) by taking placebo.
However, in the case of drinking the product of the present invention, a clear improvement effect (about 35 to 46) was observed. Similar results were obtained in counseling. In addition, no opinion such as discomfort due to taking was found. Therefore,
The product of the present invention was found to be able to ameliorate the symptoms of menopausal indefinite complaint syndrome without worrying about side effects as seen in conventional hormone therapy.

Experimental Example 2: Antihypertensive Action Using male rats, the preventive effect of the composition of the present invention on increasing blood pressure was examined. That is, 6-week-old male spontaneously hypertensive rats (SHR / izm) were divided into two groups, and a test food and a control food containing the knotweed extract (* 1) of the present invention were freely fed. The test meal was powdered feed SP (Funabashi Farm Co., Ltd.) and 0.15 knotweed extract used in Experimental Example 1 above.
%, And the control diet was a feed that contained nothing. Each group consisted of 5 animals, and were bred under the condition of 1 animal / cage for 12 weeks. The blood pressure was measured every four weeks without any anesthesia using a rat tail arterial pressure measuring device. Table 1 shows the results
Shown in

[0031]

[Table 1]

The test diet group showed a significant blood pressure increase inhibitory effect as compared with the control diet group. There was no significant difference in the amount of food consumed between the two groups.

Example 1 Concentrated Beverage A concentrated beverage was prepared from the components according to the following formulation according to a conventional method. * 2: Compressed residue of 80 grape berries after pressing
Circulating extraction with hot water of ~ 90 °, and extracting the resulting extract with Brix
The solution is concentrated by heating under vacuum until the value reaches 15, and after concentration, filtered by cooling. (Solid content: about 14%)

The obtained concentrated beverage is used as it is, or mixed with water, milk, fruit drinks or the like according to the taste. It can be used to alleviate symptoms of menopause or adult indefinite complaint syndrome and prevent recurrence.

Example 2: Beverage Each component was mixed by the following production method to prepare a beverage according to a conventional method. That is, lactic acid bacteria (S
After inoculating a starter of treptococcus lactis) and culturing until a pH of about 4 is obtained, a yogurt-like composition is obtained and homogenized. Next, a sweetener prepared by dissolving 5 parts of sugar, 10 parts of apple juice, and 30 parts of pectin in water is added to the homogenized yogurt-like composition at a weight ratio of 4: 5 and mixed. Furthermore, 10 parts of a mixture of calcium gluconate and magnesium gluconate at a weight ratio of 2: 1 dissolved in water at a ratio of 20% by weight was added and mixed. Finally, a grape skin extract (* 3) ) Is added by 10% by weight. * 3: Extraction of the pressed residue of a brew of red wine produced using Pinot Noir fruit with 70-90 ° hot water, Br
ix. The concentrated extract is obtained by heating and concentrating the mixture to about 20 and then precipitating a part of the organic acid such as tartaric acid at a low temperature of about 5 ° and separating by filtration. The obtained beverage can be used for the purpose of preventing or treating osteoporosis.

Example 3 Sugar-Coated Tablets The following components were mixed to prepare sugar-coated tablets according to a conventional method. * 4: Dried leaves of V. rotundifolia are ethanol 20
% (W / W) extracted with a supercritical carbon dioxide gas solvent, and then the solvent is removed to form a powder. The obtained sugar-coated tablet can be used for the purpose of preventing or treating osteoporosis.

Example 4: Specified health food A specified health food was prepared according to a conventional method by mixing the components according to the following formulation. * 5: Water / ethanol = 40/60 (V / V) was added to dried and ground rhizome or root of Polygonum sachalinens and extracted with stirring. Is an extract concentrated to around 15. The obtained food for specified health use can be used for the purpose of preventing hypertension.

Example 5: Granules Each component was mixed according to the following formulation, and granules were prepared according to a conventional method. Ingredient Content (%) Dextrin Residue Lactose 20.0 Heme Iron Powder 5.0 Sucrose 5.0 Soybean Isoflavone 2.5 Itadori Extract (* 1) 2.5 Vitamin C 1.0 Coffee Flavor 1.5 Vitamin D ₃₀ 0.005 Total 100.0 The obtained granules can be used for the purpose of preventing or alleviating the symptoms of menopausal and mature indefinite complaints.

Example 6: Jelly-like food A jelly-like food was prepared according to a conventional method by mixing the components according to the following formulation. The obtained jelly-like food can be used for the purpose of preventing hypertension.

Example 6: Solid food A solid food was prepared according to a conventional method by mixing the components according to the following formulation. * 6: Bee leaves dried and powdered The obtained solid food can be used for the purpose of preventing or alleviating symptoms of menopausal and adulthood indefinite complaint syndrome.

Example 6 Bread Bread was prepared according to a conventional method by mixing the components according to the following formulation. Ingredient Amount (parts by weight) Flour 100.0 Sucrose 6.0 Butter 5.0 Skim milk powder 5.0 Shortening 4.0 Salt 2.0 Yeast 2.0 Yeast food 0.2 Margarine 6.0 Grape leaf dried product (* 6) 5.0 Purified water 22.0 The obtained bread can be used for the purpose of preventing or alleviating the symptoms of menopausal and mature indefinite complaints.

[0042]

The grape plant (Vitis), knotweed and its dried product / extract have an effect of preventing diseases and complaints that occur with aging and alleviating symptoms. The composition is useful for the prevention, symptom relief and treatment of menopausal and adulthood indefinite complaint syndrome, hypertension and osteoporosis.

Claims (3)

[Claims] 1. Prevention or amelioration of climacteric and maturity indeterminate complaints, hypertension or osteoporosis, characterized by containing at least one plant selected from the genus Vitis and the Polygonaceae. Oral composition for use. 2. The composition according to claim 1, wherein the grape plant (Vitis) is of the genus Euvitis. 3. The composition according to claim 1, wherein the Polygonaceae plant is a knotweed.