JP2002047193A - Composition for prophylaxis or treatment of allergic dermatitis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral composition or a composition of a preparation for external use used for the purpose of treatment or prevention of relapse of allergic dermatitis, especially treatment or prophylaxis of atopic dermatitis. SOLUTION: This oral composition and a composition of the preparation for external use are characterized as comprising at least one or more species of plants selected from a plant of the genus Vitis and Polygonum cuspidatum Sieb. et Zucc. or dried substances/extracts thereof and are useful prophylaxis of relapse and symptom alleviating actions on the allergic dermatitis.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition having an excellent symptom-relieving action or recurrence-preventing action with no side effects on a skin damage site or an external healing site caused by allergic dermatitis. More specifically, the present invention comprises at least one or more plants selected from grape vines (Vitis) and knotweeds, and a dried product / extract thereof to prevent recurrence and alleviate symptoms of allergic dermatitis. The present invention relates to an oral composition and an external preparation composition having the composition.

[0002]

2. Description of the Related Art In recent years, the number of people suffering from allergic dermatitis has increased, and among them, the number of people suffering from atopic dermatitis has shown a rapid increase. Conventionally, most patients with atopic dermatitis develop in infancy, and many have complete healing until puberty.Some patients remain as refractory adult-type atopic dermatitis that does not relieve beyond the age of 20 years. As it has been said, the number of patients who first develop after adulthood has been increasing recently, and the cumulative number of patients has risen dramatically. In addition, the number of people who have increased skin sensitivity even if they do not lead to atopic dermatitis is increasing, which is thought to be one of the factors that increase the number of patients with allergic dermatitis such as contact dermatitis. Have been.

[0003] The reasons for such a rapid increase in the number of patients include "a great improvement in airtightness due to changes in the living environment and office environment, resulting in prolonged drying and exposure to allergen substances", and "air pollution". (Nitrogen oxides, sulfur oxides, dust) increase the burden on the immune system. "" Increase in nutrient intake and long-term use of various chemicals resulting from disturbances in dietary habits such as increased use of eating out and processed foods. However, the causes and pathological conditions of allergic dermatitis, especially atopic dermatitis, have not been elucidated,
Because there are still many unknown points, medical treatment cannot be performed fundamentally. On the other hand, considering that the ever-increasing reduction in medical costs is becoming a major issue for Japan's national administration, measures to fundamentally treat and prevent the onset of allergic dermatitis, especially atopic dermatitis Need to be found immediately.

[0004] In response to this situation, in the medical field,
"Use of external preparations such as topical steroids and non-steroidal anti-inflammatory external preparations", "anti-allergic agents,
Antihistamines, Kampo preparations, steroids, antibiotics,
Various attempts have been made, such as "internal administration such as", specific / non-specific desensitization therapy, bacterial vaccine therapy, drug bath therapy, PUVA therapy, skin care, improvement of living environment, and allergen-free diet therapy. However, it is known that even with these treatments, it is possible to improve the skin condition without any abnormalities, and at first glance it seems that the disease has been cured, but the symptoms often recur within a short period of time. ing. Recently, it has been reported that several years are required after appearance skin symptoms are completely cured in order to improve the skin function completely. If treatment and prevention of the disease are performed by medical treatment such as medication until the skin function is completely restored, the treatment cost will increase,
Long-term medication has a high risk of side effects (for example, topical steroids may cause adrenocortical dysfunction, developmental disorders, erythema with capillary dilation, skin atrophy,
There is a problem of side effects such as induction and exacerbation of infectious disease).

[0005] On the other hand, with respect to guidance on improving dietary habits, when a specific component is an allergen, it is sufficient to ingest a meal from which the component has been removed, but in practice many factors are involved. Since the disease often occurs, even if dietary improvement is carried out, the effect is often not obtained at all, and in addition, the physical condition may be deteriorated due to biased nutritional intake. In addition, even if a certain improvement effect can be expected, it is difficult to improve long-term habits and implement it for a long period of time, and it is often impossible to implement it. There is a problem that it is difficult to implement the improvement itself.

[0006] Under such circumstances, in the treatment of allergic dermatitis, especially atopic dermatitis, the treatment of dermatitis is carried out in a mild manner as possible by combining various adjuvant therapies with the use of external preparations as symptomatic treatment. It is considered that the treatment is fundamental to lead to natural remission while suppressing deterioration and repetition. Therefore, there has been a demand for the development of a composition having no side effect, which has an excellent healing promoting action on a skin damage site caused by allergic dermatitis and an inhibitory effect on an allergic reaction itself in a living body.

[0007]

SUMMARY OF THE INVENTION Accordingly, the present invention relates to an oral or topical composition having no side effects and having an excellent effect of preventing recurrence and promoting healing of allergic dermatitis, for which the fundamental solution is difficult. The purpose is to provide.

[0008]

Means for Solving the Problems The present inventors have conducted intensive studies on physiologically active substances contained in plant components, and as a result, surprisingly, when a grape genus plant or a knotweed plant is ingested continuously. The present inventors have found that prevention of onset or alleviation of symptoms of allergic dermatitis, particularly atopic dermatitis can be expected, and have completed the present invention.

The present invention has been completed on the basis of such findings, and as an advantage of this solution, there are the following advantages. It is also a supplement to life and can be easily taken, so it is especially effective when it is difficult to improve dietary habits. " No.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The grape plant (Vitis) used in the present invention is not particularly limited, but includes European and Middle Eastern varieties of Vinifera species (V. vinifera) and Silbertoris species (V. silvestris). North American varieties of Labrasca (V.labru
sca), California species (V. california), Estivalis species (V. aestivalis), Mansoniana species (V. mansoniana), Linkecummy species (V. lincecumi)
i), vulpina species (V. vulpina), candicans species (V. candicans), cordifolia species (V. cordifo)
lia). Asian varieties of amulensis (V. amurensis), yamagrape (V. coignetia)
e), Korean grape (V. amurensis), shrimp (V. thunbergii), Sankakuzul (V. flexuosa)
Genus (Euvitis) and Mussoniana species (V. munsoniana), and Roton difolia species (V.
rotundifolia) (Muscadinia). Among them, the varieties belonging to the genus Euvitis and the species Rotondifolia (V. rotundifolia),
Vinifera species (V.vinifera), Labruska species (V.labrusc)
a), and varieties bred in Japan mainly using them are preferred.

[0011] More specifically, the species Rotonifolia (V. rotundifolia) includes Carlo (Carlo).
s), Cobalt (Cowart), Doreen, Fry, Higgins, Hunt, Jumbo, Magnolia, Magnolia, Noble, Scuppernong, Steering (Sterling), Sugargate (Sugargate), Summit (Summit), Tail (Tarheel), Watergate (Watergate), and the like, and Vinifera species (V.
vinifera) include Airen, Aligote, Riesling, Sauvignon blanc, Trebbiano
bbiano), Chardonnay, Chenin blanc, Semillon, Muscat, Cabernet Sauvign
on), Carignan, Cinsau
t), Grenache Noir, Merlot, Mataro, Pinot Noir
Noir), Sangiovese (Sangiovese), Syrah (Sy)
rah), Gamay, Tempranillo
llo), Gewurtraminer, Nebbiolo, Zweigl
trebe), Muller-Thurgau, Grolleau, Cabernet Fran
c), Petit Verdot and the like.

[0012] Also, Vistula labrusca species (V. labru
sca), Zinfandel, and Rotonifolia species (V. rotundifolia): Carlos, Cobalt (Cowart), Doreen (Doree)
n), Fry, Higgins, Hunt (H
unt), Jumbo, Magnolia,
Noble, Scuppernong,
Steering (Sterling), Sugar Gate (Sugargat)
e), Summit, Tail (Tarheel), Watergate (Watergate).

Specific examples of varieties developed in Japan include Ajilon Duck, Aki Queen, Italy, Izu Nishiki, Olympia, Ohira Della, Kaiji, Cabernet Suntory, Garnet, Kyoho, Campbell Early, King Della, and Glow Coleman. , Concord, Koshu, Koshu Sansho,
Suntory Blanc, Suntory Noir, Takao, Delawella, Niagara, Neo Muscat, Honey Seedless, Honey Red, Pione, Hiro Hamburg, Bioveld, Black Queen, Black Hamburg, Brighton, Fuefuki, Fuji Minoru, Hokko, Benizuho, Beniyamabiko , Muscat Hamburg, Muscat Violet, Muscat
Of Alexandria, Muscat Berry A, Yamagrape, Riesling Lion, Rizamart, Ruby Okuyama, Ryuho, Red Queen, Red Pearl, Rosary Bianco and the like.

Particularly preferred grapes are Vinifera species (Vv
inifera) Riesling, Sauvignon blanc, Trebbia
no), Chardonnay, Cabernet Sauvignon, Carignan,
Merlot, Pinot Noir, Syrah, Gamay, Cabernet Franc (Cabern)
et Franc). Zinfandel of Vistilla bruska species (V.labrusca). Kaiji, Cabernet Suntory, Kyoho, Campbell Early, Koshu, Suntory Blanc, Suntory Noir, Takao, Delawera, Neo Muscat, Pione, Hiro Hamburg, Bioveld, Black Hamburg, Fuefuki, Fuminuki, Beni Zuiho, Beniyamabiko, Muscat Berry A,
Ryuho, Red Queen is preferred, Riesling (Ries
ling), Sauvignon Blanc,
Chardonnay, Cabernet Sauvignon (Ca
Most preferred are bernet Sauvignon, Merlot, Pinot Noir, Cabernet Franc Kyoho, Concord, Campbell Early, Delawera, Pione, Koshu, Neo Muscat, Muscat of Alexandria, Glow Coleman, Yamagrape.

The site of use of these grapes is not particularly limited, but leaves or fruits (including pericarp and seeds)
Are preferred, and in particular, leaves are most preferred.

The knotweed used in the present invention is a perennial plant belonging to the family Polygonaceae, and includes knotweed, giant knotweed, Meietsutsuso, and knotweed, and knotweed is preferred. The use site of the Polygonaceae plant is not particularly limited, but the above-ground parts or roots, rhizomes are preferable,
Further, roots and rhizomes are most preferred. The plants listed above can be used as they are, or cut, crushed, dried naturally, dried with hot air, freeze-dried, processed by fermentation, or extracted, concentrated, powdered, and granulated according to a conventional method. And the like can be used.

The extraction can be performed by a general extraction method such as an extraction method using an organic solvent or water, a critical extraction method, or the like. As such a method, for example, JP-A-61-17142
No. 7 publication. The extraction solvent is preferably a polar solvent, more preferably alcohols, water and liquefied carbon dioxide, and most preferably ethyl alcohol, water and liquefied carbon dioxide.

The amount of the above-mentioned plants in the composition of the present invention is not particularly limited in the present invention as long as the desired effect can be obtained. Can be set. For example, in the case of an oral composition,
0.0001 to 10% by weight in terms of solid content, 0.001 to
It is preferably 1% by weight, particularly preferably 0.005 to 0.5% by weight.

In the case of an external preparation composition, 0.0
It is preferably from 0.01 to 10% by weight and from 0.01 to 5% by weight, particularly preferably from 0.05 to 5% by weight. These ranges are selected in terms of palatability, effects, stability over time, and the like.

The oral composition of the present invention may be, for example, a tablet,
Lump, liquid, syrup, capsule, granule, powder,
It can be prepared in various forms such as jelly and paste according to a conventional method. Specific examples of such forms include soft drinks, fruit juice drinks, milk drinks, drinks such as tea (drinks); powdered drinks such as powdered juices and powdered soups; cookies, biscuits, chewable tablets, chewing gums, Sweets such as candies, gummy, wafers, and crackers; dressings, sauces, spreads, sprinkles, seasonings such as powder seasonings; breads, noodles,
Staple food products such as mochi, cereal, oatmeal and the like; functional foods such as foods for the sick, foods for specified health use, and dietary supplements. Further, the composition of the present invention can be used as a food material (for example, a food additive or the like) that can be used for preparing any food.

The dose and the intake of the composition of the present invention are appropriately determined depending on the form, age and sex of the patient or the recipient, other conditions, and the degree of the disease. Further, in the oral composition, in order to suppress the specific astringent taste, it is preferable to coexist proteins and protein hydrolysates, especially mixed with milk and dairy products, milk proteins and collagen hydrolysates It is preferred to add.

The composition of the present invention can be administered or taken once or several times a day for the purpose of treating allergic dermatitis or preventing recurrence. It is particularly effective when used for the purpose of preventing or treating recurrence of atopic dermatitis.

When the composition of the present invention is used as an external preparation, it may be prepared in various forms such as tablets, capsules, blocks, liquids, powders, jellies, and pastes according to a conventional method. it can. Specific examples of such forms include nutritional creams, moisturizing creams, emulsions, mist,
Lotion, serum, skin lotion, cleansing (cream, gel), UV protection cosmetics, face wash (cream, gel, powder), body powder, body shampoo, soap, body rinse, shampoo, rinse, Treatment, hair tonic, hair restorer,
Examples include scalp lotion, bath agent, hand soap, hand cream, patch, lip balm, lipstick, antiperspirant and the like. It can also be used in the form of an aerosol or impregnated in wet tissue, cotton, diapers, or the like.

The composition of the present invention may contain, if necessary, components usually used in pharmaceuticals, cosmetics and foods, for example, other medicinal components, micronutrients (vitamin, etc.) as long as the effects of the present invention are not impaired. , Minerals, dietary fiber, etc.), animal and plant components (milk-related components, fats and oils, waxes, polysaccharides, amino acids and proteolytic peptides and their ester derivatives, polyphenols (including glycosides), phospholipids, crush Juice, solvent extract, etc.), anionic surfactant,
Nonionic surfactants, cationic surfactants, amphoteric surfactants, alcohols (lower alcohols, higher alcohols, polyhydric alcohols and their ester derivatives, etc.), organic and inorganic acids and their salts, polymers (agar, tamarind) Natural polymers such as gum, xanthan gum, pectin, gelatin, sodium alginate, starch; cationized cellulose, methylcellulose, carboxymethylcellulose, hydroxyethylcellulose,
Semi-synthetic polymers such as hydroxypropyl methylcellulose, cationized starch, cationized collagen, cationized xanthan gum; synthetic polymers such as polyethyleneimine, polyethylene glycol, acrylic polymers, vinyl polymers, methacrylic polymers) Agent, extender,
Antioxidants, ultraviolet absorbers, ultraviolet scattering agents, sweeteners, flavoring agents, coloring agents, flavors, preservatives and the like can be added.

[0025]

EXAMPLES Hereinafter, the present invention will be described in more detail based on examples and experimental examples, but the present invention is not limited to these examples. In addition, the numerical value of the compounding amount means "% by weight" unless otherwise specified.

Experiment 1 Inhibition of histamine release It is known that in a type I allergic reaction, chemical mediators such as histamine are released from sensitized mast cells or basophils. Therefore, these substances that suppress the histamine release reaction can be expected to have an antiallergic effect. In this test, a human basophil cell line (KU812) was used.
The effect of inhibiting histamine release using the cells was measured.

(Test method) KU812 cells were cultured in RPMI1640 medium (GIBCOBR) containing 10% fetal bovine serum.
L) at 37 ° C. under 5% CO ₂ . The cells were supplemented with histamine release buffer (* 1), 1500 rpm, 4 ° C., 5
After centrifugation for 1 minute, remove the supernatant, and after washing twice, 10 ⁵ cel
Prepared ls / ml with histamine release buffer. 100 μl of cell suspension and 0.0 prepared in histamine release buffer
1%, 0.05% knotweed extract (* 2) or 1.0
100% of dipotassium glycyrrhizinate in 1.5%
The mixture was placed in a ml eppendorf tube and left under ice cooling for 30 minutes. Then, centrifuge at 1500 rpm, 4 ° C for 5 minutes,
The cells obtained by removing the supernatant are combined with histamine release buffer 2
After mixing again with 00 μl, 3 μl of 1 mg / ml high-affinity IgE receptor antibody (CRA-1, Kyokuto Pharmaceutical Co., Ltd.) was added, followed by incubation at 37 ° for 30 minutes. The measurement is 20
The supernatant obtained by centrifugation at 00 rpm at 4 ° C. for 10 minutes was performed using a histamine EIA kit (IM-MUNOTECH).

(Calculation method) From the histamine calculated from the calibration curve, the histamine release inhibition rate (%) was determined based on the following equation (1). The measurement was performed at n = 5, and represented by an average value and a standard deviation. The results are shown in Table 1. * 1: 30 mM Tris-HCl (pH 7.6), 120 mM NaCl, 5 mM
KCl, 1 mM CaCl ₂ , 1 mM MgCl ₂ , 0.03% BSA * 2: Knotweed (Polygonum cuspidatum Sieb. Et Zuc
c.) A rhizome containing the roots is dried and pulverized, water / ethanol = 30/70 (volume ratio) is added, stirred and extracted, and then powdered.

[0029]

(Equation 1)

[Amount of histamine of test substance (A): amount of histamine released from cells to which test substance and CRA-1 were added (nM), amount of histamine of negative control (B): released from untreated cells Histamine amount (n
M), histamine level of positive control (C):
Amount of histamine released from cells to which only CRA-1 was added (nM)].

[0031]

[Table 1]

From the results shown in Table 1, it was confirmed that the knotweed extract has a remarkably excellent release inhibiting action as compared with dipotassium glycyrrhizinate.

Example 1: Sugar-coated tablets Dragee-coated tablets were prepared according to the following formulation and according to a conventional method. Ingredients Amount (%) Starch 60.0 Powdered reduced maltose starch syrup 20.0 Lactose 15.0 Itadori extract (* 2) 5.0 Total 100.0 The obtained sugar-coated tablets alleviate the skin symptoms of atopic dermatitis Can be administered or taken for prophylaxis.

Example 2 Beverage Additives Each component was mixed according to the following formulation to prepare a beverage additive according to a conventional method. Ingredients Blended amount (%) Grape skin extract concentrate (* 4) 50.0 Ethyl alcohol 20.0 Maltose 15.0 Isomerized sugar liquid sugar (fructose content 50%) 10.0 Ascorbic acid 5.0 Preservatives Trace Total 100.0 * 4: The crushed Kyoho fruit is circulated and extracted with hot water at 80 to 90 ° C, and the obtained extract is concentrated by heating under vacuum until the Brix value reaches around 10. After concentration, the mixture is cooled and filtered. (Solid content: 9%) The obtained beverage additive can be used as a preparation for use in a beverage used for the purpose of, for example, alleviating the symptoms of allergic dermatitis and preventing recurrence, and as an in-use preparation. When used as a business preparation agent, it is mixed with a beverage such as water or a fruit juice beverage at an arbitrary ratio and used for drinking. The mixing ratio is optional, but is suitably about 5 to 10% by weight based on the beverage to be mixed.

Example 3 Beverage Each component was mixed by the following production method to prepare a beverage according to a conventional method. That is, lactic acid bacteria (S
treptcoccus lactis), pH 4
After culturing until a yogurt-like composition is obtained,
Homogenize. Next, a sweetener prepared by dissolving 5 parts of sugar, 10 parts of apple juice, and 30 parts of pectin in water is added to the homogenized yogurt-like composition at a weight ratio of 4: 5 and mixed. Furthermore, 10 parts of a mixture of calcium gluconate and magnesium gluconate in a weight ratio of 2: 1 dissolved in water at a ratio of 20% by weight was added and mixed. Finally, a grape leaf extract (solid content) About 10%) to 10
% By weight. The resulting beverage can treat and prevent recurrence of allergic dermatitis.

Example 4: Patch A patch was prepared according to a conventional method by mixing the components according to the following formulation. Ingredients Amount (%) Polyvinyl alcohol 20.0 White petrolatum 10.0 Ethyl alcohol 5.0 Carboxymethylcellulose sodium 5.0 Itadori extract (* 2) 3.0 Trimethylglycine 3.0 1-Menthol 1.0 Purified water Remainder Total 100.0 The resulting patch can be used for alleviating skin symptoms of atopic dermatitis and preventing recurrence.

Example 5: Ointment Each component was mixed according to the following formulation to prepare an ointment according to a conventional method. Ingredients Amount (%) White petrolatum 30.0 Glycerin 20.0 Squalane 10.0 Cetyl alcohol 5.0 Magnesium stearate 3.0 1-Menthol 1.0 Grape leaf extract (* 5) 0.05 Purified water Remaining Total 100.0 * 5: Dipped leaves of Pinot Noir were immersed and extracted at a bath ratio of 1:10 (dry leaves: ethanol) for 5 hours while stirring slowly, and the obtained extract was dried under reduced pressure to obtain powder. It is obtained by performing a chemical conversion treatment. The obtained ointment can be used for alleviating skin symptoms of allergic dermatitis and preventing recurrence.

Example 6: Lotion A lotion was prepared according to a conventional method by mixing the components according to the following formulation. Ingredients Compounding amount (%) Knotweed extract (* 6) 20.0 Isoprene glycol 5.0 Dipotassium glycyrrhizinate 0.2 Hydroxypropyl methylcellulose 0.1 Methylparaben 0.05 1-Menthol 0.03 Purified water Remaining Total 100.0 * 6: Knotweed (Polygonum cuspidatum Sieb. Et Zuc
c.) The rhizomes containing the roots were dried and pulverized, water was added at 40 times the weight in weight, and the mixture was stirred and extracted for 3 hours while maintaining the liquid temperature in the range of 60 to 80 ° C., followed by cooling filtration and concentration under reduced pressure. It is obtained about 2 times concentrated in the apparatus. (Solid content: about 9%) The obtained lotion can be used for alleviating skin symptoms of allergic dermatitis and preventing recurrence.

Example 7: Emulsion Emulsion was prepared by mixing each component according to the following formulation according to a conventional method. Ingredients Amount (%) Propylene glycol 5.0 Stearyl glycyrrhetinate 2.5 Squalane 2.0 Sodium citrate 2.0 Cetyl alcohol 1.5 Polyoxyethylene hydrogenated castor oil 1.0 1-Menthol 1.0 Polyoxyethylene 0.5 Sorbitan monostearate carboxymethylcellulose 0.2 Methyl paraben 0.05 Itadori extract (* 2) 0.01 Purified water Remainder Total 100.0 The obtained emulsion is used to alleviate or relapse the skin symptoms of allergic dermatitis Can be used for prevention.

Example 8: Shampoo Each component was mixed according to the following formulation to prepare a shampoo according to a conventional method. Ingredients Compounding amount (%) Polyoxyethylene (3) 10.0 Sodium lauryl ether sulfate Polyoxyethylene (3) 10.0 Sodium lauryl sulfosuccinate Giant knotweed extract (* 7) 10.0 Coconut oil fatty acid dimethylpropyl 5.0 Betaine aminoacetate Palm oil fatty acid diethanolamide 3.5 Propylene glycol 3.0 Cationized cellulose 0.5 l-menthol 0.5 Sodium benzoate 0.5 Perfume and pigment Appropriate amount Purified water Remainder Total 100.0 * 7: Oitadori (Polygonum sachalinens) rhizomes and roots were dried and ground, and water / ethanol =
30/70 (volume ratio) added and extracted with stirring. (3% solid content) The obtained shampoo can be used for preventing recurrence of skin symptoms of allergic dermatitis.

Example 9: Treatment A treatment was prepared by mixing the components according to the following formulation and following a conventional method. Ingredients Amount (%) Stearyltrimethylammonium chloride 5.0 Distearyldimethylammonium chloride 2.0 Nettlebird extract (* 7) 10.0 Cetanol 3.0 Propylene glycol 4.0 Dimethylpolysiloxane (20cs) 4.0 Dimethyl Polysiloxane (1 million cs) 2.0 Stearyl alcohol 1.0 Isopropyl palmitate 0.5 Methyl paraben 0.3 Perfume, pigment, UV absorber Appropriate amount Purified water Remaining total 100.0 The treatment obtained is allergic dermatitis Skin symptoms can be prevented.

Example 8: Body rinse A body rinse was prepared according to a conventional method by mixing the components according to the following formulation. Ingredients Blended amount (%) Isoprene glycol 30.0 Squalene 20.0 Giant knotweed extract (* 8) 10.0 Polyoxyethylene hydrogenated castor oil 5.0 Decamethylcyclopentasiloxane 3.0 Dimethylpolysiloxane (1,000,000 cs) 2.0 1-Menthol 0.5 Sodium benzoate 0.5 Purified water Remaining Total 100.0 * 8: Water / ethanol = 50/5 after drying and pulverizing leaf of Polygonum sachalinens
0 (volume ratio) at a bath ratio of 1: 5 (dry leaves: extraction solvent), followed by extraction for 12 hours with stirring. (Solid content 4%) The obtained body rinse can be used for alleviating the symptoms of skin symptoms of allergic dermatitis and preventing recurrence.

Example 8 Bath Agent A bath agent was prepared according to a conventional method by mixing the components according to the following formulation. Ingredients Amount (%) Sodium bicarbonate 60.0 Anhydrous sodium sulfate 32.0 Borax 3.0 Itadori extract (* 2) 1.0 1-Menthol 0.1 Total 100.0 It can be used to alleviate skin symptoms of allergic dermatitis and prevent recurrence.

Example 9: Food for the sick The ingredients for the sick were mixed according to the following formulation to prepare a food for the sick according to a conventional method. Ingredients Amount (%) Sugar syrup 40.0 Sugar 13.0 Knotweed extract (* 2) 4.0 Preservatives, acidulant Suitable amount Total 100.0 The resulting food preparation for the sick is atopic dermatitis skin It can be used to alleviate symptoms and prevent recurrence.

Example 10: Jelly-like food A jelly-like food was prepared by mixing the components according to the following formulation and according to a conventional method. Ingredients Blended amount (%) Grape skin extract concentrate (* 4) 30.0 Grape concentrated reduced juice 10.0 Sugar 8.0 Carrageenan 1.5 Citric acid 0.1 Grape flavor 0.03 Purified water Remaining Total 100.0 The obtained jelly-like food can be used for alleviating the skin symptoms of atopic dermatitis and preventing recurrence.

[0046]

EFFECTS OF THE INVENTION Since grape plants (Vitis) and knotweeds and their dried products / extracts have an effect of preventing recurrence and treatment of allergic dermatitis, an oral composition containing them has an effect on disease. It can also be consumed as functional foods such as foods for the elderly, foods for specified health use, and dietary supplements. In addition, the external preparation composition is useful for treating and preventing recurrence of allergic dermatitis, particularly atopic dermatitis.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (Reference) // A23G 3/00 101 A23G 3/00 101 A23L 1/06 A23L 1/06 2/52 2/38 C 2/38 2/00 F

Claims (3)

[Claims] 1. An oral composition useful for preventing or alleviating allergic dermatitis, comprising at least one member selected from the group consisting of grape vines (Vitis) and knotweeds. 2. An external preparation composition useful for preventing recurrence and alleviating symptoms of allergic dermatitis, which comprises at least one selected from grape plants (Vitis) and knotweeds. 3. The composition according to claim 1, wherein the allergic dermatitis is atopic dermatitis.