JP2001335471A - Plaster - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a plaster capable of easily peeling off a peel sheet and sticking neatly and surely in a short time when peel-off operation of the peel sheet and sticking operation of the plaster to an affected part are simultaneously done, and, on the other hand, and an adhesive agent layer of which is surely protected so that the peel sheet is not peeled off when the plaster is not used. SOLUTION: The plaster has a support material, the adhesive agent layer laminated on the support material and the peel sheet stuck on the whole surface of the adhesive agent layer. The plaster is featured that bending resistance of the peel sheet is 20-100 mm, tensile strength is 5-30 N/cm, elongation percentage is 250-750%, 180 degree peel strength between the peel sheet and the adhesive agent layer is 0.03-0.4 N/40 mm and a cut part with a predetermined space is formed on the peel sheet.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a patch, and more particularly, to a patch having a release sheet.

[0002]

2. Description of the Related Art In recent years, as the aging society progresses, the frequency of use of various computers due to rationalization of office work has increased, and as a result, the number of people who complain of pain on the waist, shoulders, knees, elbows and the like tends to increase. Patches such as cataplasms and plasters are widely used as these symptomatic treatments.

[0003] Conventionally, as a patch, a pressure-sensitive adhesive layer containing a drug is laminated on a support, and a release sheet for protecting the pressure-sensitive adhesive layer is adhered to the entire surface of the pressure-sensitive adhesive layer. Is common. The patch having such a configuration is adhered to the affected area after peeling off the peeling sheet by searching for the corners with a nail or the like, but the peeling sheet is difficult to peel off, and wastes a lot of time in the peeling work or during the peeling work There is a problem that the patch is twisted and becomes entangled and becomes unusable.

[0004] Therefore, various attempts have been made to improve the releasability of the release sheet and to improve the convenience of the patch, and as one of the attempts, a cut portion or a cut portion provided at a predetermined portion of the release sheet is used. A patch is proposed that allows the peeling sheet to be peeled off and the patch to be applied at the same time by peeling off the peeling sheet while applying the exposed adhesive layer to the affected area so that the peeling sheet can be turned from the cut. Have been.

Japanese Patent Application Laid-Open No. 10-265372 discloses that a continuous cut line is provided in a release sheet, the bending strength of the release sheet is 70 to 150 mm, and the 180-degree peel force between the release sheet and the adhesive layer is 1 to 10 g / g. A patch in which the release property of the release sheet is improved by setting it to 15 mm is disclosed. However, if a continuous cut line is provided in the release sheet as in the above-mentioned patch, the release property of the release sheet certainly improves, but even when the patch is not used, the release sheet is turned up from the cut portion and the adhesive layer is exposed. This has the disadvantage that the medicinal component volatilizes from the exposed portion of the pressure-sensitive adhesive layer and a sufficient medicinal effect cannot be obtained during use.

Japanese Patent Application Laid-Open No. 8-112305 discloses a patch having cut portions formed on a release sheet at predetermined intervals and embossed portions formed on both ends of the cut portion. Have been. However,
Even with the above patch, the peelability of the release sheet to be stuck to the affected area more cleanly and securely in a short time without causing the patch to become entangled or wrinkled, and the corners and the like turning up when not in use However, it has not yet been sufficient to satisfy a sufficient balance between the release-preventing property of the release sheet for protecting the pressure-sensitive adhesive layer and the protective layer.

[0007]

DISCLOSURE OF THE INVENTION The present invention has been made in view of the above-mentioned problems of the prior art, and is intended for use in the case where the operation of peeling a release sheet and the operation of applying a patch to an affected area are performed simultaneously. It is intended to provide a patch in which the adhesive layer is easily peeled off and can be stuck to the affected area cleanly and securely in a short time, while the adhesive layer is securely protected without turning up the release sheet when not in use. Aim.

[0008]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to achieve the above object, and have found that the release sheet has a stiffness, a tensile strength, an elongation, and a gap between the release sheet and the pressure-sensitive adhesive layer. The release force of the release sheet satisfies a certain condition, and the patch having cut portions at predetermined intervals in the release sheet has contradictory properties of the release property of the release sheet when used and the release prevention property of the release sheet when not used. They have found that they are satisfied with a sufficient balance, and have completed the present invention.

That is, the patch of the present invention comprises a support,
An adhesive comprising a pressure-sensitive adhesive layer laminated on the support and a release sheet adhered to the entire surface of the pressure-sensitive adhesive layer,
The release sheet has a stiffness of 20 to 100 mm, a tensile strength of 5 to 30 N / cm, an elongation of 250 to 750%, and a 180-degree release force between the release sheet and the pressure-sensitive adhesive layer of 0.03. 0.4 N / 40 mm, and has a cut portion formed at a predetermined interval in the release sheet and a connecting portion formed between cut portions adjacent to each other.

According to the present invention, the release sheet has a rigidity of 2
0-100 mm, a tensile strength of 5-30 N / cm, an elongation of 250-750%, a 180-degree peeling force between the release sheet and the adhesive layer of 0.03-0.4 N / 40 mm, and the release By providing cuts at predetermined intervals in the sheet, contradictory properties of the release property of the release sheet when the patch is used and the release prevention property of the release sheet when not used are sufficiently balanced. Therefore, when simultaneously performing the peeling operation of the release sheet and the attaching operation of the patch to the affected area, the release sheet can be easily peeled off and stuck cleanly and securely to the affected area in a short time. Sometimes the pressure-sensitive adhesive layer can be protected without the peel-off sheet being turned up.

The rigidity referred to herein is JIS L
A value [mm] measured by the cantilever method specified in 1085.

Further, the tensile strength and elongation according to the present invention are determined by a method according to JIS Z 1702, using a 10 mm wide strip-shaped test piece and a grip width of 5 mm.
It refers to the load [N / cm] and elongation [%] when the test piece is pulled at 0 mm at a pulling speed of 300 mm / min and broken.

Further, the 180-degree peeling force according to the present invention is determined by a method according to JIS C 2107 using a rheometer so that the angle between the release sheet and the patch after peeling becomes 180 degrees. The load [N / 40 mm] when the release sheet is peeled from the patch under the conditions of a grip width of 40 mm and a pulling speed of 300 mm / min.

In the patch of the present invention, the ratio of the length (a) of the connecting portion formed between adjacent cut portions to the length (b) of the cut portion is a: b = 1: 8. １ ： 1: 25 is preferred. When the ratio between the length of the connecting portion and the length of the cut portion is within the above range, the release sheet during use is sufficiently suppressed while the separation of the release sheet during non-use and the resulting exposure of the pressure-sensitive adhesive layer are sufficiently suppressed. Tends to be more easily separated and peeled.

[0015]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will be described below in detail with reference to the accompanying drawings.

FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention, and FIG. 2 is a sectional view of a main part thereof. The patch 1 includes a support 2, an adhesive layer 3 laminated on the support 2, a release sheet 4 attached to the entire surface of the adhesive layer 3,
It consists of And, in the adhesive patch 1 of the present invention, the release sheet 4 has a stiffness of 20 to 100 mm, a tensile strength of 5 to 30 N / cm, and an elongation of 250 to 750.
%, The 180-degree peeling force between the release sheet 4 and the pressure-sensitive adhesive layer 3 is 0.03 to 0.4 N / 40 mm, and the release sheet 4 has a predetermined interval, A part 5 is provided.

The rigidity of the release sheet according to the present invention is 20 to 100 mm as described above, and preferably 30 to 7 mm.
0 mm. If the stiffness of the release sheet is less than 20 mm, the release sheet will not be able to hold the support firmly when applying the patch, and the patch will twist and become entangled or wrinkled on the patch after application. Will come closer. On the other hand, when the bending resistance of the release sheet exceeds 100 mm, the release sheet becomes hard, and as a result, it becomes difficult to apply the patch neatly and easily in a short time.

Further, the tensile strength of the release sheet according to the present invention is 5 to 30 N / cm, preferably 10 to 25 N / cm as described above. As the tensile strength of the release sheet becomes smaller, the separation of the release sheet tends to become easier, but even if it is less than the lower limit, it may be caused by a small external force applied when manufacturing the patch or taking out the patch. The release sheet is divided, which causes entanglement of the patch and volatilization of the medicinal component from the divided part. On the other hand, if the tensile strength of the release sheet exceeds the upper limit, a strong force is required to divide the release sheet, and the feeling of use and work efficiency when attaching the patch are deteriorated.

Further, the elongation percentage of the release sheet according to the present invention is from 250 to 750% as described above, and preferably from 300 to 600%. As the elongation percentage of the release sheet becomes smaller, the release sheet tends to be easily separated, but if it is less than 250%, a small external force is applied during the production of the patch or when removing the patch from the packaging bag. This also causes the release sheet to be divided, causing entanglement of the patch and volatilization of the medicinal component from the divided portion. On the other hand, if the elongation percentage of the release sheet exceeds 750%, the release sheet is difficult to be divided even though the release sheet is sufficiently elongated, and the usability and work efficiency at the time of sticking the patch are deteriorated.

Furthermore, the 180-degree peeling force between the release sheet and the pressure-sensitive adhesive layer according to the present invention is 0.0 as described above.
3 to 0.4 N / 40 mm, preferably 0.05 to
0.3 N / 40 mm. If the 180-degree peeling force between the release sheet and the pressure-sensitive adhesive layer is less than the lower limit, the release sheet is likely to be peeled off at the time of production or storage of the patch, and the entanglement of the patch and volatilization of the medicinal component from the peeled portion. Cause. On the other hand, if the 180-degree peel force exceeds the upper limit, the release sheet is less likely to be peeled off from the patch, the usability and working efficiency when attaching the patch is reduced, and the patch is easily entangled or wrinkled. It becomes difficult to stick cleanly.

The release sheet used in the present invention includes:
There are no particular restrictions on the softness, tensile strength and elongation as long as they satisfy all of the above conditions and can reliably protect the pressure-sensitive adhesive layer. Specifically, unstretched polypropylene ( CPP), expanded polypropylene (OPP), polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyethylene, polyester,
Processed paper such as plastic film of polyurethane, polyvinyl chloride, polystyrene, etc., synthetic resin, synthetic paper, silicon-processed paper obtained by silicon processing of synthetic fiber; aluminum foil, kraft paper, laminated paper obtained by laminating polyethylene etc. It can be used as it is colorless or colored in a desired color. Here, the thickness of the release sheet is preferably 10 μm to 75 μm, more preferably 1 μm to 75 μm.
2 μm to 40 μm, more preferably 15 μm to 35 μm
It is. When the thickness of the release sheet is less than 10 μm, at the time of release, the release sheet slips and is difficult to be picked, and the release sheet tends to be entangled with the pressure-sensitive adhesive layer and the feeling of use tends to be reduced. In addition, the release sheet tends to be easily cut or the release sheet is wrinkled, resulting in a decrease in workability. On the other hand, when the thickness of the release sheet exceeds 75 μm, the release sheet is easy to be gripped, but the separation tends to be difficult, and in addition, it becomes difficult to cut the raw sheet at the time of manufacturing, and Properties tend to decrease.

As shown in FIGS. 1 and 2, the release sheet used in the present invention has a cut 5 formed at a predetermined interval and a connection formed between two adjacent cuts 5. Part 6. Here, the ratio of the length (a) of the cut portion 5 to the length 6 (b) of the connecting portion is preferably a: b = 1: 5-1: 25, more preferably 1: 5.
8 to 1:25, more preferably a: b = 1: 8 to 1:
20, most preferably from 1: 8 to 1:15. When the length (b) of the cut portion 5 is less than 5 times the length (a) of the connecting portion 6, the release sheet is less likely to be divided when sticking the patch, and the feeling of use is worsened. At the time of production of a patch, it is difficult to cut the raw sheet, and the working efficiency tends to decrease. On the other hand, if the length (b) of the cut portion 5 exceeds 25 times the length (a) of the connecting portion 6, the release sheet is likely to be divided at the time of manufacture or storage of the patch, and the release sheet may be divided into portions. There is a tendency that the patch is entangled and entangled with the patch, or the medicinal component volatilizes from the divided portion, and the medicinal effect of the patch is reduced.

There is no particular limitation on the position where the cut portion 5 according to the present invention is provided. For example, the cut portion 5 may be provided so as to cross the release sheet 4 at a substantially central portion or a peripheral portion thereof. Examples of the shape of the cut portion 5 include a straight shape shown in FIGS. 1 and 2, an S shape, a wave shape, a saw blade shape, and the like, and particularly, the cut portion has an S shape, a wave shape, or a saw blade shape. This is preferable because the protruding pieces formed at predetermined intervals can be picked up and the release sheet can be smoothly peeled off from the patch, and the convenience at the time of sticking is improved.

Further, although not shown in FIGS. 1 and 2, in the present invention, it is preferable to provide an embossed portion on the entire surface or a part of the surface of the release sheet 4. When an embossed release sheet is used, the hand becomes less slippery in the separation and separation operations of the release sheet, so that the working efficiency tends to be higher. The shape of the embossed portion is not particularly limited as long as it is not slippery and easy to pick by hand, and specific examples include a lattice shape, a round shape, a square shape, and a star shape. Also, when embossing a part of the release sheet surface, the position is not particularly limited,
For example, by providing an embossed portion at a place where it is easy to pick by hand when separating the release sheet such as a portion having a width of 10 to 20 mm from both ends of the cut portion, the release sheet is more reliably divided without slipping the hand can do.
In addition, as described later, since the release sheet is turned up from the cut portion when the release sheet is cut, the release sheet that has been turned up after the cut can be more reliably peeled off by providing an embossed portion near the cut portion. . In addition, in order to clarify the method of dividing the release sheet,
It is also possible to provide a display section on which graphics such as arrows, characters, symbols, and the like are printed on both sides of the cut portion on the surface of the release sheet.

As the support used in the present invention, a woven fabric,
Knitted fabric, non-woven fabric, non-woven paper, or stretchable or non-stretchable such as a laminate thereof, as the material,
Cellulose fibers such as bast fibers such as paper, cotton, cannabis and jute, and leaf vein fibers such as Manila hemp; animal fibers such as wool; natural fibers such as silk fibers and feather fibers; regenerated cellulose fibers such as rayon and cupra; Regenerated fiber such as protein fiber; semi-synthetic fiber such as cellulose acetate fiber and promix; nylon aramid fiber, polyethylene terephthalate fiber, polyester fiber, acrylic fiber, etc., polyolefin fiber such as polyethylene and polypropylene; polyvinyl alcohol fiber, polyvinyl chloride fiber , Polyvinylidene chloride fiber,
Polyurethane fiber, polyoxymethylene fiber, polytetrafluoroethylene fiber, polyparaphenylenebenzbisthiazole (PBT) fiber, polyimide fiber, and the like can be used. These supports have thickness, elongation,
Tensile strength, physical properties such as workability and feel at the time of application, sealing properties of the affected part, appropriately selected in consideration of the transferability of the drug to the support, etc., a support having a predetermined elasticity, More specifically, it is preferable to use a support having a stretch ratio of 10 to 300% in the vertical and / or horizontal direction measured according to the method of JIS L 1096. With such a support, the difference in elongation between the support and the release sheet,
By simply pulling the release sheet together with the support, the separation of the release sheet and the release from the pressure-sensitive adhesive layer can be easily performed. On the other hand, also in the case of using a non-stretchable support, the release sheet can be separated and peeled by utilizing the sliding of the release sheet and the pressure-sensitive adhesive layer, which is preferable because the convenience at the time of sticking is improved.

Among the above-mentioned supports, non-woven fabrics of polyester fibers are particularly preferably used because they have little effect on the medicinal component, and the basis weight is preferably 30 to 150 g / m2.
² , more preferably 35 to 120 g / cm ² , particularly preferably 40 to 100 g / m ² . Also,
The thickness of the yarn constituting the support is preferably 0.1 to 2 denier. If the thickness of the thread is within the above range, the patch is less likely to be peeled off, and the feeling of use tends to be improved even when the patch is applied to a place where the movement of the elbow, knee, face, etc. is large and the skin stretches greatly. is there.

The thickness of the support used in the present invention is as follows: the support is made of a woven fabric, a knitted fabric, a non-woven fabric other than polyester,
Or it is preferably 0.3 to 3 mm in the case of non-woven paper, and 1 ± 0.5 in the case of using polyester non-woven cloth.
mm.

In the present invention, the pressure-sensitive adhesive layer laminated on the support has an adhesive force capable of fixing the drug to the skin surface at room temperature for a long time, and is softened so that the plaster adheres to the skin. Those having cohesiveness to the extent that they do not remain are preferable,
Water, thickeners, wetting agents, fillers, and other additives such as crosslinking agents, polymerization agents, solubilizers, absorption enhancers, medicinal auxiliaries, stabilizers, antioxidants, emulsifiers, and chemicals are added as necessary. You.

The thickener used in the plaster according to the present invention preferably has a water content of 30 to 80% by mass and a stable water retention. Specific examples include guar gum, locust bean gum, carrageenan, alginic acid, sodium alginate, agar, arabic gum, tragacanth gum, karaya gum, pectin, starch and other plant systems, xanthan gum, acacia gum and other microbial systems, gelatin, collagen and other animals. -Based natural polymers, methylcellulose, ethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, carboxymethylcellulose sodium-based cellulose-based, soluble starch, carboxymethyl starch, semi-synthetic polymer such as dialdehyde starch, etc., polyvinyl alcohol, polyvinyl Vinyls such as pyrrolidone and polyvinyl methacrylate, acrylics such as polyacrylic acid and sodium polyacrylate, and other polyethylene oxides
A water-soluble polymer such as a synthetic polymer such as a methyl vinyl ether / maleic anhydride copolymer is preferably used. In particular, as such a thickener, sodium polyacrylate having high gel strength and excellent water retention is preferably used, and sodium polyacrylate having an average degree of polymerization of 20,000 to 70,000 is preferably used. As the average degree of polymerization becomes smaller than 20,000, the gel tends to be insufficient and sufficient gel strength cannot be obtained, and as the average degree of polymerization becomes larger than 70,000, the thickening effect becomes too strong and the workability tends to decrease. Not preferred. Further, by using two or more of the above water-soluble polymers in combination, for example, a polymer complex is formed with a strong ionic polymer of sodium polyacrylate, and an elastic gel having higher gel strength is formed. Obtainable.

Examples of the wetting agent used in the plaster according to the present invention include polyhydric alcohols such as glycerin, propylene glycol and sorbitol, and examples of the filler include kaolin, zinc oxide, talc, titanium, benite, and aluminum silicate. , Titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate and the like.

As a solubilizing agent or an absorption promoter,
Propylene carbonate, crotamiton, l-menthol, peppermint oil, limonene, diisopropyl adipate and the like, and as a medicinal auxiliary, methyl salicylate, glycol salicylate, l-menthol, thymol, peppermint oil, limonene,
Nonylate varanilideamide, capsicum extract and the like may be added to the plaster according to the present invention. If necessary, a stabilizer, an antioxidant, an emulsifier, or the like may be added to the plaster according to the present invention.

In addition, if necessary, a crosslinking agent or a polymerizing agent may be added to the plaster according to the present invention to strengthen the plaster (adhesive) and to retain water. Such a crosslinking agent and a polymerizing agent can be appropriately selected according to the type of the thickener and the like. For example, when polyacrylic acid or polyacrylate is applied to the thickener, a compound having at least two epoxy groups in the molecule, a hydrochloride such as Ca, Mg, or Al, a sulfate, a phosphate, Inorganic acid salts such as carbonates, organic acid salts such as citrate, tartrate, gluconate and stearate, oxides such as zinc oxide and silicic acid, and hydroxides such as aluminum hydroxide and magnesium hydroxide And the like are preferably used. When polyvinyl alcohol is used as the thickener, adipic acid, thioglycolic acid, epoxy compound (epichlorohydrin), aldehydes, N-methylol compound, Al, Ti, Zr, S
Complexes such as compounds such as n, V, Cu, B, and Cr are preferably used. When polypyrrolidone is used as the thickener, a methyl vinyl ester / maleic anhydride copolymer, a polyacid compound or an alkali metal salt (polyacrylic acid, tannic acid and derivatives thereof), etc. are preferably used. When polyethylene oxide is used as the thickener, peroxide, polysulfone azide and the like are preferably used. When a methyl vinyl ether / maleic anhydride copolymer is used as a thickener, a polyfunctional hydroxy compound, polyamine, iodine, gelatin,
Polyvinyl pyrrolidone, iron, mercury, lead salts and the like are preferably used. When gelatin is used as the thickener, aldehydes such as formaldehyde, glutaraldehyde and dialdehyde starch, diepoxides such as glyoxal and butadiene oxide, diketones such as divinyl ketone, and diisocyanates are preferably used.

When the patch of the present invention holds a drug, the drug may be blended into the pressure-sensitive adhesive layer. Such drugs include, for example, general anesthetics, sleep, painkillers,
Antipyretic antiphlogistic analgesics, steroid hormones, stimulants / stimulants, psychiatric agents, local anesthetics, skeletal muscle relaxants, autonomic agents, antiallergic agents, antihistamines, inotropic agents, arrhythmias, diuretics, antihypertensives , Vasoconstrictors, vasodilators, calcium antagonists, antibacterials, agents for parasitic skin diseases, emollients, antibiotics, antidotes, antitussives, antipruritics,
Hypnotics, psychoactive agents, asthma agents, hormone secretagogues, anti-ulcer agents, anticancer agents, vitamins, and the like, and these agents include methyl salicylate, glycol salicylate, l-menthol, pepper extract, nonylate wanilylamide, Mentha oil, diclofenac, ibuprofen, indomethacin, ketoprofen, loxoprofen, sulindac, tolmetin, lobenzarit, penicillamine, fempfen, flurbiprofen, suprofen, felbinac, ketorolac, oxaprozin, etodolac, zaltoprofen, tenidap, piroxibuphine, pentaxazoline hydrochloride, pentaxazoline Nonsteroidal anti-inflammatory drugs such as butorphanol; prednisolone, dexamethasone, hydrocortisone, betamethasone, fluocinide Fluocinolone acetonide,
Prednisolone acetate valerate, dexamethasone dipropionate, diflucortron valerate, difluprednate,
Betamethasone valerate, hydrocortisone butyrate, clobetasone butyrate, betamethasone butyrate, clobetasone propionate, dexamethasone succinate, prednisolone 21-
(2E, 6E) farnesheet, hydrocortisone valerate, diflorazone acetate, dexamethasone propionate,
Drugs such as betamethasone dipropionate, amcinodo, dexamethasone valerate, halcinonide, butesonide, and steroidal anti-inflammatory drugs such as alclomethasone propionate are contained as active ingredients. Here, the above-mentioned drugs may be used in combination of two or more if necessary, and may be in the form of a derivative such as an ester, an acetal or an amide, or a medically acceptable inorganic or organic salt. May be used. Furthermore, the amount of the drug used in the patch of the present invention is appropriately selected so that a preset effective amount can be applied to the affected part. Further, the patch may contain a whitening component, a beautiful skin component and the like in addition to the above-mentioned drugs.

As a preferred example of the pressure-sensitive adhesive layer when the patch of the present invention is applied to a poultice, the following composition: Thickener: 20 to 50% by mass (more preferably 10 to 15% by mass)
% By mass) Wetting agent: 5 to 40% by mass Filler: 0 to 20% by mass Water: 10 to 80% by mass Solubilizing agent: 0 to 8% by mass Drug: 0 to 5% by mass (preferably 0.5 to 5%) % By mass). When the composition of the pressure-sensitive adhesive layer is within the above range, the skin has good skin adhesion; the skin absorbability of the active ingredient is high; the water content is as high as possible; There is a tendency to achieve a very high level of properties such as no pain when the patch is peeled off; no stain or stickiness on the affected area after the patch is peeled off.

When the patch of the present invention is applied to a plaster or the like, the base material may be an acrylic copolymer, A-
Those having a BA block copolymer, an alicyclic petroleum resin, and a softener are preferably used. Further, AB type block copolymer and other polybutene rubber, butyl rubber,
Silicone rubber, natural rubber, styrene butadiene copolymer, thermoplastic elastomer such as NBR polyisobutylene, polyalkyl acrylate, synthetic isoprene, terpene resin, petroleum resin, rosin, hydrogenated rosin, rosin
Tackifiers such as hydrogenated rosin esters, liquid paraffin,
Animal and vegetable oils such as olive oil, soybean oil, beef tallow, tongue fat, polybutene, liquid polyisobutylene, low-grade isoprene, adhesives and holding power regulators such as wax, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate, etc. A filler is compounded. As the ABA-type block copolymer and the AB-type block copolymer, a block copolymer of a monovinyl-substituted aromatic compound A and a conjugated diolefin copolymer B is suitably used, The amount is 10 to 40% by mass, preferably 15 to 30% by mass in the pressure-sensitive adhesive composition. If the compounding ratio of the block copolymer is within the above range, the compatibility and anchoring power of the medicinal component, and the cohesive force due to the oil component can be improved while the adhesive strength is improved, but it is out of the range. Therefore, these effects tend to decrease.

The thickness (coating thickness) of the pressure-sensitive adhesive layer laminated on the support in the patch of the present invention is 0.1 mm to 3 mm.
mm is preferred. When the thickness of the pressure-sensitive adhesive layer exceeds 3 mm, the release property of the drug contained in the plaster tends to deteriorate, while when it is less than 0.1 mm, the adhesiveness to the skin is poor, and it tends to cause peeling.

The thickness of the patch of the present invention including the support and the pressure-sensitive adhesive layer is preferably 0.5 mm to 5 mm. When the thickness including the support and the pressure-sensitive adhesive layer exceeds 5 mm, the edge of the patch is stuck to clothes and the like at the time of sticking and tends to peel off, while if less than 0.5 mm, the patch has no supportability. In addition, the patches tend to be entangled or wrinkled, making it difficult to apply them cleanly and easily in a short time.

Further, in the patch of the present invention, it is preferable that the corner is cut in an arc shape. The patch after peeling off the release sheet, once turned up, once peeled off, the stratum corneum and dust adhere to the part,
It is difficult to stick again. In particular, when the shape of the poultice is rectangular, the corners tend to be caught on clothing or the like, turned up first, and easily peeled off. Therefore, it is preferable that the corner of the cataplasm is formed in an arc shape so as to be hardly caught on clothes or the like, whereby the occurrence of peeling tends to be more sufficiently prevented.

Further, when the corners of the patch of the present invention are formed in an arc shape, the arc has a radius of curvature (R) of 5 mm.
It is preferably about 20 mm. This radius (R) is 5
If it is less than 20 mm, there is a tendency that reduction of peeling at the time of sticking is not sufficiently achieved, while if it is more than 20 mm, the phenomenon of peeling off from a corner is prevented, but much waste is produced during production. Manufacturing costs tend to be high and profits tend to be poor.

The conventional patch has the drawback that the peeling effect of the release sheet is increased while the effect of preventing peeling is increased by making the corners of the patch into an arc shape. In the above, since the contradictory properties of the release property of the release sheet during use and the anti-peeling property of the release sheet during non-use are satisfied in a well-balanced manner as described above, the release sheet is separated and separated at a cut portion. It is easy to perform, and in addition, the adhesiveness of the patch of the present invention inherently and the difficulty of peeling due to the arc shape of the corner are combined to improve the peeling preventing effect synergistically. It becomes possible.

An example of the method for using the patch of the present invention having the above-described structure will be described below. FIG.
FIG. 4 is an explanatory view showing an operation of separating the release sheet of the patch shown in FIG. 1, and FIG. 4 is an explanatory view showing an operation of attaching the patch shown in FIG. 1 to an affected part. First, as shown in FIG.
By pinching both ends of the patch 1 and pulling the release sheet 4 together with the support 2 to slightly bend the cut portion 5, the release sheet 4 can be divided right and left along the cut portion 5. The separated release sheet 4 is turned up from the separated portion by the elasticity of the release sheet just by slightly bending the cut portion 5, and the adhesive layer 3 is exposed.
Next, as shown in FIG. 4, while the exposed pressure-sensitive adhesive layer 3 is applied to the affected part, each piece of the peeled-off release sheet 4 is pulled to the left and right to peel off the release sheet 4 and remove the peeled sheet from the affected part. The operation of attaching the patch 1 is performed at the same time.
Thus, by using the patch of the present invention, the patch can be stuck neatly and easily to the affected part in a short time without entanglement or wrinkling.

[0042]

EXAMPLES Hereinafter, the content of the present invention will be described in more detail based on examples and comparative examples, but the present invention is not limited to the following examples.

Example 1 A patch as shown in FIG. 1 was prepared according to the following procedure.

A stretchable polyester nonwoven fabric (basis weight: 100 g / m ² , thread thickness: 1 denier) was used as a support. Further, 5% by mass of sodium polyacrylate, 2% by mass of polyvinyl alcohol, 2% by mass of kaolin, 10% by mass of glycerin, 0.5% by mass of aluminum hydroxide as a thickener, and 0.5% by mass of ketoprofen as a drug
% By mass and 80% by mass of water were blended, and the mixture was used as a plaster. Then, a plaster was spread on the support to form an adhesive layer.

Next, unstretched polypropylene (thickness: 30 μm, softness: 20 mm, tensile strength: 5 N / cm, elongation: 280%) was used as a release sheet. This release sheet is adhered to the entire surface of the pressure-sensitive adhesive layer, and the ratio of the length (a) of the connecting portion to the length (a) of the cut portion is approximately at the center of the release sheet, where a: b = 1: 8 to provide the desired patch (long side: 14 cm, short side:
10 cm). The 180 degree peeling force between the release sheet and the pressure-sensitive adhesive layer of the obtained patch was 0.15 N / 40 mm.

Example 2 Instead of the release sheet used in Example 1, a release sheet made of unstretched polypropylene (thickness: 50 μm, softness: 50 mm, tensile strength: 22 N / cm, elongation: 7)
A patch was prepared in the same manner as in Example 1 except that 30%) was used. The 180-degree peeling force between the release sheet and the pressure-sensitive adhesive layer of the obtained patch was 0.05 N / 40 mm.

Example 3 A release sheet made of polyethylene (PE) instead of the release sheet used in Example 1 (thickness: 40 μm, bending resistance: 60 mm, tensile strength: 14.7 N / cm, elongation: 410) %) Was used in the same manner as in Example 1 except that the patch was used. The 180-degree peeling force between the release sheet of the obtained patch and the pressure-sensitive adhesive layer is 0.3 N / 40 mm.
Met.

Example 4 A release sheet made of polyethylene instead of the release sheet used in Example 1 (thickness: 50 μm, softness: 80 m)
m, tensile strength: 26 N / cm, elongation: 600%), and a patch was prepared in the same manner as in Example 1. The 180-degree peel force between the release sheet and the pressure-sensitive adhesive layer of the obtained patch was 0.4 N / 40 mm.

Example 5 Instead of the release sheet used in Example 1, a release sheet made of unstretched polypropylene (thickness: 100 μm, bending resistance: 100 mm, tensile strength: 30 N / cm, elongation:
310%) in the same manner as in Example 1 except that
A patch was prepared. The 180 degree peeling force between the obtained release sheet of the adhesive patch and the pressure-sensitive adhesive layer is 0.3 N / 40.
mm.

Example 6 The procedure was performed except that the cut portion was provided such that the ratio of the length (a) of the connecting portion of the release sheet to the length (b) of the cut portion was a: b = 1: 5. A patch was prepared in the same manner as in Example 1.

Example 7 Except that the cut portion was provided such that the ratio of the length (a) of the connecting portion of the release sheet to the length (b) of the cut portion was a: b = 1: 15. A patch was prepared in the same manner as in Example 1.

Comparative Example 1 In place of the release sheet used in Example 1, a release sheet made of unstretched polypropylene (thickness: 20 μm, bending resistance: 15 mm, tensile strength: 4 N / cm, elongation: 24)
0%) was used in the same manner as in Example 1 to prepare a patch. The 180 degree peeling force between the obtained release sheet of the adhesive patch and the pressure-sensitive adhesive layer is 0.1 N / 40 mm.
Met.

Comparative Example 2 A release sheet made of polyethylene instead of the release sheet used in Example 1 (thickness: 80 μm, softness: 120)
mm, tensile strength: 43 N / cm, elongation: 310%)
A patch was prepared in the same manner as in Example 1 except that the patch was used. The 180 degree peeling force between the obtained release sheet of the patch and the pressure-sensitive adhesive layer was 0.3 N / 40 mm.

Comparative Example 3 In place of the release sheet used in Example 1, a release sheet made of stretched polypropylene (thickness: 50 μm, bending resistance:
80 mm, tensile strength: 35 N / cm, elongation: 150
%) Was used in the same manner as in Example 1 except that the patch was used. The 180-degree peeling force between the obtained release sheet of the adhesive patch and the pressure-sensitive adhesive layer is 0.05 N / 40 mm.
Met.

Comparative Example 4 In place of the release sheet used in Example 1, a release sheet made of stretched polypropylene (thickness: 30 μm, bending resistance:
50 mm, tensile strength: 15 N / cm, elongation: 130
%) Was used in the same manner as in Example 1 except that the patch was used. The 180-degree peel force between the release sheet and the pressure-sensitive adhesive layer of the obtained patch was 0.5 N / 40 mm.

Comparative Example 5 A release sheet (thickness: 40 μm) made of stretched propylene treated with silicon instead of the release sheet used in Example 1.
m, bristles: 45 mm, tensile strength: 26 N / cm, elongation: 420%), and a patch was prepared in the same manner as in Example 1. The 180-degree peeling force between the obtained release sheet of the patch and the pressure-sensitive adhesive layer is 0.01.
N / 40 mm.

Using the patch thus obtained, the following sensory evaluation test was carried out.

Test Example 1 For each of the patches of Examples 1 to 5 and Comparative Examples 1 to 5, 20 healthy adult men and women were the subjects, and each subject pulled each patch to the left and right to remove the release sheet. The following criteria are used when separating, peeling, and sticking to the sticking site (knee): 5: very easy to peel 4: easy to peel 3: relatively easy to peel 2: hard to peel 1: very hard to peel It was evaluated based on: Table 1 shows the average value of the scores obtained for each patch.

The adhesive preparations of Examples 1 to 5 in which the bending softness, the tensile strength, the elongation, and the 180-degree peeling force between the release sheet and the pressure-sensitive adhesive layer all satisfy the conditions of the present invention. In each case, it was confirmed that the release sheet could be easily separated and peeled without turning over the release sheet in a portion other than the cut portion, and that the usability at the time of sticking was good.

On the other hand, when the patches of Comparative Examples 1 to 5 were used, a good feeling in use could not be obtained. Specifically, in the case of the patch of Comparative Example 1, it was difficult to support the patch because the release sheet was soft, and the patch was likely to be entangled or wrinkled at the time of sticking. In the case of the patch of Comparative Example 2, the release sheet was difficult to be divided, and the release sheet was hard, so that it was difficult to smoothly adhere along the applied portion. In the case of the patch of Comparative Example 3, a very strong force was required for separating the release sheet. In the case of the patch of Comparative Example 4, the release sheet was hardly peeled off, and the patch was likely to be entangled or wrinkled during sticking. Comparative Example 5
In the case of the patch, the separation of the release sheet was easy,
The peelability of the release sheet was excessively high, and it was difficult to support the patch at the time of application. In the patch of Comparative Example 5, a phenomenon in which the release sheet was turned from the corner was observed.

Test Example 2 For each of the patches of Examples 1, 6 and 7, a test was conducted in the case where 20 healthy male and female adults were the subjects, and each subject pulled each patch to the left and right to separate the release sheet. Easiness of division (easiness of division) is evaluated based on the following criteria: 5: very easy to split 4: easy to split 3: relatively easy to split 2: hard to split 1: very difficult to split did. Table 1 shows the average values of the obtained scores.

As shown in Table 1, it was confirmed that the patches of Examples 1, 6, and 7 all had high easiness of division, and among them, Examples 1 and 7 showed particularly high easiness of division. Was.

Test Example 3 Each of the patches of Examples 1 to 5 and Comparative Examples 1 to 5 was put in an aluminum foil packaging bag with a release sheet adhered, and sealed by heat sealing. This aluminum foil packaging bag is 40 ℃,
After storing for 1 month under the condition of 75% RH, the patch was taken out of the packaging bag and the presence or absence of peeling between the pressure-sensitive adhesive layer and the release sheet was evaluated according to the following criteria. No peeling was observed between them. ×: Partial peeling was observed between the pressure-sensitive adhesive layer and the release sheet. Table 1 shows the results.

As shown in Table 1, none of the patches of Examples 1 to 5 showed peeling of the release sheet when not used.

As described above, it was confirmed that in the patches of Examples 1 to 7, high releasability at the time of use and high anti-peelability at the time of non-use were achieved in a sufficiently balanced manner. On the other hand, in the case of the patches of Comparative Examples 1 to 5, at least one of the releasability at the time of use and the anti-peeling property at the time of non-use was insufficient, and a good feeling in use was not obtained.

[0066]

[Table 1]

[0067]

As described above, according to the present invention, when the peeling operation of the release sheet and the operation of applying the patch to the affected area are performed at the same time, the release sheet can be easily and neatly cleaned in a short time. The adhesive can be securely adhered to the affected area, while a patch in which the pressure-sensitive adhesive layer is securely protected without turning up the release sheet when not in use can be obtained.

[Brief description of the drawings]

FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention.

FIG. 2 is a sectional view of a main part of the patch shown in FIG.

FIG. 3 is an explanatory view showing an example of an operation of dividing the release sheet of the patch shown in FIG. 1;

FIG. 4 is an explanatory view showing an example of an operation of attaching the patch shown in FIG. 1 to an affected part.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... patch, 2 ... support, 3 ... adhesive layer, 4 ... release sheet, 5 ... cut part, 6 ... connecting part.

Claims (2)

[Claims] 1. A support, a pressure-sensitive adhesive layer laminated on the support, a release sheet stuck on the entire surface of the pressure-sensitive adhesive layer,
Wherein the release sheet has a stiffness of 2
0-100 mm, a tensile strength of 5-30 N / cm, an elongation of 250-750%, and a 180-degree peeling force between the release sheet and the pressure-sensitive adhesive layer of 0.03-0.4 N / 4.
A patch having a cutout of 0 mm and formed at predetermined intervals on the release sheet. 2. In the release sheet, the ratio of the length (a) of the connecting portion formed between adjacent cut portions to the length (b) of the cut portion is a: b = 1: 8- The patch according to claim 1, wherein the ratio is 1:25.