JP2001354573A - Anti-allergenic composition and method for deactivating allergen - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an anti-allergenic composition for deactivating environmental allergens in the environments, and to provide a method for deactivating such allergens. SOLUTION: This anti-allergenic composition comprises a high-molecular compound having ammonium salt on the main chain or side chain and a molecular weight of >=3,000. The other objective method for deactivating allergens comprises using the above composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an anti-allergen composition for inactivating environmental allergens and a method for inactivating allergens using the same.

[0002]

2. Description of the Related Art Allergic diseases such as asthma and atopic dermatitis have been plagued by many people for many years. Causes of these allergic diseases (hereinafter referred to as allergens)
As typical examples, mite, pet hair, pollen, and the like living indoors are well known. At present, pharmacotherapy is mainly applied to the treatment of allergic patients, while removing allergens from the living environment of the patient and rational measures to protect patients directly from exposure to allergens are also possible. It is. Such symptom improvement by allergen removal has been reported in Europe and the United States in addition to Japan.

[0003] As a method of removing allergens, there are suction by an electric vacuum cleaner, removal by an air cleaner, use of a high-density cover for bedding, and the like. However, there is a limit to the amount of allergen that can be removed only by suction using a vacuum cleaner, and an air purifier can only remove allergens that fly in the air. In addition, in the case of a high-density cover of bedding, allergens are removed from the inside, but allergens are not removed from the outside, and these methods are not always satisfactory.

As a method for chemically inactivating allergens, a method using tannic acid is proposed in Japanese Patent Publication No. 2-16731, and a method using tea extract, gallic acid or the like is proposed in JP-A-6-279273. ing. However, in these methods, there is a problem that it is difficult to obtain a stable allergen inactivation effect, and furthermore, some coloring occurs on the processed object.

[0005] Acaricides are generally used to control mites in house dust. Dermatophagoides farinae and Dermatophagoides pteronyssinus in house dust have allergenic properties even after dying. As it breaks down, it gradually releases allergens in particulate form, so killing a tick alone does not inactivate the allergen.

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve such problems, and as a result, a composition containing a high molecular compound having an ammonium salt or an amine in the molecule has been subjected to treatment. The present invention has found an antiallergen effect without causing coloring of the performed object, and a method for stably inactivating allergens in the environment by treating this composition in the environment. . That is, the present invention provides an anti-allergen composition comprising a high molecular compound having an ammonium salt or an amine in a main chain or a side chain and having a molecular weight of 3,000 or more, and spraying the anti-allergen composition to form an allergen. This is a method of inactivating allergens.

[0007] Cationic polymers having an ammonium salt are used in applications such as antistatic agents in resins and the like, antibacterial agents for textiles and the like, fixing agents for dyeing with dyes, and flocculants for aqueous suspensions. I have. For example, JP-A-7-18
No. 7936 proposes a polymer using a diallyldialkylammonium salt as a monomer as an antibacterial treating agent. However, it has not been found that a cationic polymer having an ammonium salt has the effect of inactivating allergens.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The polymer compound in the anti-allergen composition of the present invention has a structure of an ammonium salt or an amine in a main chain or a side chain (general formulas 1 to 4).

[General formula 1]

[General formula 2]

[General formula 3]

[General formula 4] (R1-R3 may be the same or different in the formula, a hydrogen or an alkyl group having 1 to 12 carbon ^{atoms, X m-represents} a counter ion.
m represents the valence of the counter ion. Examples of polymers having an ammonium salt in the main chain include polyalkylenepolyamines, and polymers having an ammonium salt in the side chain include diallyldialkylammonium, allylamine hydrochloride, and trialkylallylammonium salts. Polymers of Examples of the counter ion ( ^Xm- ) include anions such as a halogen ion, a phosphate ion, a lactate ion and a propionate ion, and usually include a chloride ion. Examples of the polymer having an amine include polyallylamine.

Among the polymers having an ammonium salt or an amine, those exhibiting good antiallergenicity are those having a molecular weight of 3,000 or more, and more preferably those having a molecular weight of 1 or more.
0000 or more. The polymer may have a structure having an ammonium salt or an amine, and functional groups such as a hydroxyl group, a thiol group, a sulfone group, a sulfonic acid group, a carboxyl group, a carbonyl group and a nitro group coexist in addition to the ammonium salt and the amine. It does not matter. Further, a copolymer with another vinyl monomer or the like may be used.

The dosage form of the anti-allergen composition of the present invention is as follows:
As long as a treatment that can inactivate allergens in the environment is possible, any dosage form such as a liquid, a powder, or a paste may be used. However, the use of a liquid is easy and effective. In order to carry out such a preparation, an ammonium salt or an amine having a main chain or a side chain and a molecular weight of 3000 is used.
Solvents suitable for dissolving or dispersing the above-mentioned polymer compound can be used alone or as a mixed solvent of two or more kinds. The solvent is not particularly limited, for example, water, methyl alcohol, ethyl alcohol, isopropyl alcohol, benzyl alcohol, acetic acid, acetone, dimethylformamide, dimethylacetamide, dimethylsulfoxide, ethylene glycol, propylene glycol, diethylene glycol, triethylene glycol,
Dipropylene glycol, hexylene glycol, polyethylene glycol, glycerin, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether acetate, γ-butyrolactone, sulfolane, etc. Non-polar solvents such as polar solvents, dimethylnaphthalene, dodecylbenzene, liquid paraffin, isophorone, kerosene, dibutyl adipate, diethyl phthalate, diethylene glycol monobutyl ether acetate, propylene carbonate, coconut oil, rapeseed oil, cottonseed oil, castor oil, and soybean oil It can be used as appropriate.

The anti-allergen composition of the present invention can be used in any convenient form such as an aqueous solution, spray, aerosol, etc., but is not particularly limited. Compositions that may come into contact with humans in the environment, such as textile processing agents, detergents, soaps, shampoos, softeners, deodorants, fungicides, disinfectants, insecticides, paints, adhesives, etc. It is also possible to inactivate allergens in the environment by adding them to materials that may come into contact with humans in the environment, such as building materials such as wood, concrete, metal, stone, and glass, rubber, and paper. It is also possible to inactivate allergens in the environment by processing them into molded articles made of resin or plastic.

[0012] The anti-allergen composition of the present invention can be used by mixing with other allergen inactivating agents. Also,
When used for the purpose of removing allergens from indoor dust mites, the effect can be further maintained by mixing with acaricides. The acaricide to be used is not particularly limited as long as it has a lethal effect or a repellent effect on indoor dust mites, for example, benzyl alcohol,
Benzyl benzoate, phenyl salicylate, cinnamaldehyde, hyssop oil, carrot seed oil and the like can also be used. Dicofol, chlorbenzylate, hexthiazox, tebufenpyrad, pyridaben and the like can be used.

In preparing the preparation of the present invention, a surfactant, a chelating agent, a rust inhibitor,
Antibacterial agent, binder, thickener, fragrance, scale inhibitor,
It is also possible to add a pH adjuster, an antifoaming agent, an antistatic agent, a softening agent and the like.

As a method of using the anti-allergen composition of the present invention, a method of inactivating the allergen by directly spraying it on carpets, tatami mats, beddings, curtains, stuffed animals and the like contaminated with the allergen is generally considered. There is no coloring of the object according to the invention. It is also effective to directly treat bedding and the like contaminated with allergens, such as gluing during washing. Further, a method of laying a cotton cloth or a non-woven fabric treated with the composition of the present invention on bedding is also effective. Before the treatment of the anti-allergen composition, it is desirable to treat miticides having a high degree of contamination with mites, or to wash the whole with a vacuum cleaner or suction with a vacuum cleaner.

The use of the present invention makes it possible to inactivate mite allergens and plant allergens (such as cedar pollen) in house dust, and to substantially reduce various allergens. Therefore, the present invention is particularly effective when the environmental allergen is mite allergen or house allergen in house dust.

[0016]

The present invention will be described in more detail with reference to Examples and Test Examples, but the present invention is not limited by these.

[0017]

[Anti-allergen compositions Examples 1 to 12] The components having the following compositions were thoroughly stirred to obtain a uniform solution. In addition, all the compounding ratios shown in the table are% by weight.

Example 1 Polyallyldimethylammonium chloride 2% (average molecular weight 40,000) (N is an integer of 1 or more) Ethanol 15% Water 83% (Total) 100%

Example 2 Polyallyldimethylammonium chloride 2% (average molecular weight 200000) ethanol 15% water 83% (total) 100%

Example 3 2% poly (diallylmethylammonium chloride) (average molecular weight: 20,000) (N is an integer of 1 or more) Ethanol 15% Water 83% (Total) 100%

Example 4 Polyallyl trimethylammonium chloride 2% (average molecular weight 20,000) (N is an integer of 1 or more) Ethanol 15% Water 83% (Total) 100
%

Example 5 Poly (hydroxypropylene) dimethylammonium chloride (average molecular weight 20,000) 2% (N is an integer of 1 or more) Ethanol 15% Water 83% (Total) 100%

Example 6 Polyallylamine hydrochloride (average molecular weight 3000) 2% (N is an integer of 1 or more) Ethanol 15% Water 83% (Total) 100%

Example 7 Polyallylamine hydrochloride (average molecular weight 5000) 2% ethanol 15% water 83% (total) 100%

Example 8 Polyallylamine hydrochloride (average molecular weight 60000) 2% ethanol 15% water 83% (total) 100%

Example 9 Polyallylamine hydrochloride (average molecular weight 15000) 2% ethanol 15% water 83% (total) 100%

Example 10 Polyallylamine hydrochloride (average molecular weight 15000) 2% Diethylene glycol monomethyl ether 20% Water 78% (Total) 100%

Example 11 Polyallylamine (average molecular weight 15000) 2% (N is an integer of 1 or more) Lactic acid 2% Ethanol 15% Water 81% (Total) 100%

Example 12 Polyallylamine (average molecular weight 15000) 2% ethanol 15% water 83% (total) 100%

Comparative Example 1 Ethylhexylamine (molecular weight 129) 2% Ethanol 15% Water 83% (Total) 100%

Comparative Example 2 Didecyldimethylammonium Chloride (Molecular Weight 361) 2% Ethanol 15% Water 83% (Total) 100%

Comparative Example 3 Benzalkonium chloride (molecular weight: 349) 2% Ethanol 15% Water 83% (total) 100%

Comparative Example 4 Ethylhexylamine (molecular weight 129) 2% Lactic acid 2% Ethanol 15% Water 81% (Total) 100%

[0034]

[Test Example 1] Measurement of inactivation effect of mite allergen by anti-allergen composition Standard house dust (about 0.02 g) containing about 26 μg of mite allergen was placed on an unused carpet (50 cm x 50 cm).
m) and then left for about 1 hour. Thereafter, about 12 ml of the anti-allergen composition of Example 1 was sprayed, left at room temperature for about 4 hours, and air-dried. Suction for 1 minute with a vacuum cleaner equipped with a dust sampler (manufactured by Shinto Fine Co., Ltd.), a dust filter (manufactured by Shinto Fine Co., Ltd.), and a mighty felt (manufactured by Shinto Fine Co., Ltd.) House dust was collected. Mighty felt and phosphate buffer (pH 7.0, containing 15% by weight of bovine serum albumin) 1
0 mL was placed in a vinyl bag with a zipper and rubbed well to extract mite allergen. After the extract was centrifuged (12,000 rpm × 60 min), mite allergen test was performed using the supernatant. For the mite allergen test, an indoor dust mite simple test kit, Mighty Checker (manufactured by Shinto Fine Co., Ltd.) was used. Table 1 shows the criteria for determining the amount of mite allergen by the mighty checker. Similarly, Examples 2 to 12 and Comparative Example 1
The same operation was performed for ~ 3, and the mite allergen inactivating effect of each preparation was measured. In addition, the same operation was performed except that the spraying of the example or the comparative example was not performed, and a blank was obtained. Table 2 shows the results. In Examples 1 to 12, the mite allergen amount is lower than any of the blanks,
It showed a mite allergen inactivation effect. On the other hand, in the comparative example, the amount of mite allergen was hardly changed from that of the blank, and no effect of inactivating mite allergen was shown.

[0035]

[Table 1] Judgment criteria of mite allergen amount by mighty checker

[0036]

[Table 2] Mite allergen inactivation effect according to Example 1 and Example 2

[0037]

By treating the antiallergen composition of the present invention containing a polymer compound having an ammonium salt in the main chain or side chain and having a molecular weight of 3000 or more,
It has become possible to inactivate allergens.

 ──────────────────────────────────────────────────続 き Continued on front page F-term (reference) 4C086 AA01 AA02 FA03 MA01 MA04 NA14 ZB13 4J043 PA02 PC015 PC016 PC065 PC066 QA03 QA05 RA09 SA42 SA43 SB01 UA511 ZA60 ZB60 4J100 AN02P AN03P AN04P AN05P AN14P CA01 JA53

Claims (3)

[Claims] 1. An anti-allergen composition comprising at least one polymer compound having an ammonium salt or amine in the main chain or side chain and having a molecular weight of 3000 or more. 2. The anti-allergen composition according to claim 1, wherein the ammonium salt or amine in the structure of the polymer compound is at least one of formulas (1) to (4). [General formula 1] [General formula 2] [General formula 3] [General formula 4] (R1-R3 may be the same or different in the formula, a hydrogen or an alkyl group having 1 to 12 carbon ^{atoms, X m-represents} a counter ion.
m represents the valence of the counter ion. ) 3. A method for inactivating allergens, which comprises spraying the anti-allergen composition according to claim 1 or 2 to inactivate allergens in the environment.