JP2001226251A - Skin care composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To inexpensively provide a skin care composition that can give the skin sustainable moisture-retaining and softening properties with lowered irritation. SOLUTION: This skin care composition comprises glycerol and urea and can be served as a cosmetic for therapy, prophylaxis and alleviation for sicca dermatosis.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to urea and glycerin which are useful for treating, alleviating and preventing atopic dermatitis, keratosis, ichthyosis, dry skin eczema, dry skin, etc., and also as cosmetics. The present invention relates to a skin moisturizing softening external composition.

[0002]

2. Description of the Related Art Conventionally, for the treatment or prevention of dry skin diseases such as dry skin eczema, atopic dermatitis and keratosis, and for the improvement of dry skin and skin bulkiness. A treatment for applying an external preparation for skin containing a substance having a keratin water-retaining action to the skin has been performed.

At present, urea is the most commonly used substance as an active ingredient of such external preparations for skin, that is, a substance having a keratin water retention action. Urea has a keratolytic action in addition to its keratin water-retaining action, and exhibits an extremely excellent action as a skin moisturizer and emollient for treating the above-mentioned diseases. External preparations for skin containing urea as an active ingredient include keratinamine Kowa ointment (Kowa Co., Ltd.) (urea: 20% by mass) and urepearl ointment (Otsuka Pharmaceutical Co., Ltd.) (urea:
Ointment such as Urea Pearl L lotion (Otsuka Pharmaceutical Co., Ltd.) (urea: 10% by mass) and pastalone lotion (Sato Pharmaceutical Co., Ltd.) (urea: 10% by mass).
Mass%), which has been used as an effective therapeutic agent for dry skin diseases.

[0004] However, these agents have a high keratin moisture retention effect immediately after application and provide a moisturizing feeling, but have a disadvantage that the moisturizing effect is lost with time and the moisturizing feeling is less persistent. . Therefore, it was necessary to apply these drugs to the affected area at least several times a day in order to maintain moisture retention. Also, these agents are expensive to manufacture and, as a result, are expensive products.

[0005]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a highly moisturizing effect, excellent sustainability, low irritation and low cost for treating the above-mentioned diseases such as dry skin disease. The objective is to develop an external therapeutic agent for skin that can be manufactured.

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies to solve such problems, and as a result, the combination of glycerin and urea has an extremely excellent moisturizing effect,
The present invention has been found to have a hypoallergenic and long-lasting effect, and has completed the present invention. Accordingly, the present invention provides an external composition for skin containing glycerin and urea.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention has been completed based on the finding that a combination of urea and glycerin exerts a synergistic effect on the skin moisturizing effect. Therefore, the composition according to the present invention comprises urea and glycerin. It is characterized by containing glycerin. Urea is a colorless or white powdered compound represented by the chemical formula: CO (NH ₂ ) _2, which is known to have a keratin water-retaining action and a keratin softening action, and is widely used for treating dry skin diseases. Used as an active ingredient. The amount of urea used in the composition according to the present invention is not particularly limited as long as it is a physiologically acceptable amount, but if the amount is small, a desired effect cannot be obtained, and if it is too large, pain, heat, hypersensitivity and Since side effects such as eczema appear, the amount of 0.
Preferably, it is contained in an amount of about 1 to 30% by mass. More preferably, the amount is 1% by mass or more, still more preferably 5% by mass or more, most preferably 10% by mass or more, and preferably 30% by mass or less, more preferably 25% by mass or less, and most preferably 20% by mass or less. It is. Specifically, urea is preferably from 5 to 30 based on the total weight of the composition.
%, More preferably from 10 to 30% by weight, most preferably from 10 to 20% by weight.

[0008] Glycerin is also called glycerol,
It is a water-absorbing, colorless, transparent, viscous liquid that is miscible with water, ethanol, etc., and is represented by the chemical formula: C ₃ H ₈ O ₃ . This compound is used as an internal solution and an enema solution, and has been used as an external preparation for skin effective for cracks, irritations, and rough skin for a long time. The present invention is characterized by combining glycerin with urea. The amount of glycerin in the composition according to the present invention is not particularly limited as long as it is a physiologically acceptable amount, but if it is too small, the desired effect cannot be obtained. Since side effects such as redness appear, 1% by mass to 8%
Preferably, it is contained in an amount of about 0% by mass. More preferably, glycerin is from 1 to 70% by weight, more preferably from 1 to 60% by weight, still more preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, most preferably from 10 to 40% by weight.
30% amount.

Urea can be dissolved in glycerin, but if an amount of urea that cannot be dissolved in glycerin is used, it is necessary to add a suitable solvent to the composition according to the present invention. The solvent for dissolving the urea may be any solvent that mixes urea and glycerin and is physiologically acceptable, but generally, urea can be dissolved at an extremely high concentration. Water, especially sterile water, distilled water, etc.
Alternatively, an aqueous solution, for example, an aqueous potassium hydroxide solution can be used. Although irritating, alcohols, especially ethanol, can also be used. When urea is not completely soluble in glycerin, it is preferable to dissolve urea in a solvent and then mix the solution with glycerin to produce the present composition. The amount of the solvent is enough to dissolve urea, and depends on the amounts of urea and glycerin used and the solubility in the solvent. 1 g of urea is water 1 at normal temperature
ml, 95% ethanol 10 ml, and glycerin 2
Since it can be dissolved in ml, the amount of the solvent used depends on the solvent, the ratio of glycerin to the solvent, the amount of the additive, etc., but is preferably 1 to 90% by mass based on the mass of the composition. %, More preferably 5 to 80% by mass,
More preferably, it is 10 to 70% by mass, more preferably 10% by mass.
-60% by mass, most preferably 20-50% by mass.

The present composition may be applied to the skin as it is by coating, rubbing or spraying, or may be applied after being impregnated with absorbent cotton or gauze. It can also be applied or rubbed as an ointment. The amount of administration varies depending on the location, condition, size, etc. of the affected part, but may be any amount applicable to the entire affected part, and is not particularly limited. The number of applications varies depending on the desired effect, but once a day or less.
A few applications are sufficient, and a single application can maintain a moisturizing feeling for a long time.

The composition may include other pharmacologically active ingredients for application to the skin. For example, a bactericidal disinfectant for dermis, for example, acrinol, isopropanol, ethanol, etc .; a wound protective agent, for example, aluminum chlorohydroxy allantoinate; Indomethacin, a heparin-like substance; an agent for parasitic skin diseases such as sulfur, salicylic acid, bifonazole, miconazole; an emollient other than urea such as sulfur; and other active substances such as iodine may be added to the composition according to the present invention. Good. Provided that they do not cause undesired chemical reactions with the other components in the composition according to the invention.

Further, the composition according to the present invention generally contains an external preparation for skin for controlling viscosity, increasing moisturizing effect, increasing emollient effect, and improving simplicity, preservability and ease of use. Or you may add the auxiliary additive added to the cosmetics for skin. Such additives include thickeners, surfactants, humectants, softeners, defoamers, wettable powders, propellants, propellants, ultraviolet absorbers, antioxidants, sequestering agents,
Examples include preservatives, vitamins, polymer compounds, esters, triglycerides, higher alcohols, fatty acids, polyhydric alcohols, pigments, fragrances and the like.

Specific examples include compounds commonly added to skin external preparations, such as petrolatum, paraffin wax, lanolin, jojoba oil, gay wax, tallow, olive oil, silicone oil, castor oil, cetanol, oleyl alcohol, Stearic acid, oleic acid, 1,3-butanediol, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, ethanol, carbopol, potassium hydroxide, silicone,
Modified cellulose, for example, hydroxyethyl cellulose, methyl cellulose, hydroxypropyl cellulose and carboxymethyl cellulose, sodium alginate, gum arabic, cellulose derivatives and the like can be added.

Since the present composition has a keratin water-retaining action and a keratin softening action, it requires a skin disease,
In particular, it can be applied to dry skin diseases. Applicable skin diseases include atopic dermatitis, keratosis, for example, palmoplantar keratosis, progressive palmar keratoderma, senile xerosis, footpad Rete dermatitis, lichen pilaris, Ichthyosis, dry skin eczema, and dry skin, fissure dermatitis, scaling dermatitis, cracks, red oak,
The skin is rough. Due to these properties, the compositions according to the invention may be used as cosmetics or added to other cosmetics.

[0015]

The composition according to the present invention has a keratin moisture-retaining action and an emollient action over a long period of time, so that it can be applied to the skin to cure dry skin diseases such as atopic dermatitis, keratosis such as palm Keratoderma keratosis, progressive palmar keratoderma, senile xeroderma, footpad Reticular dermatitis, lichen pilaris,
It can treat, alleviate and prevent ichthyosis, dry skin eczema, and dry skin, fissure dermatitis, scaling dermatitis, cracks, red ants, and rough skin. Further, the present composition has low irritation, so that it is easy to use and can be easily produced using inexpensive materials.

Continued on front page F-term (reference) 4C083 AA082 AA122 AB032 AC012 AC072 AC102 AC121 AC122 AC242 AC681 AD092 AD152 AD262 AD272 AD282 AD302 AD352 AD512 CC02 EE12 EE13 4C206 AA01 CA05 HA27 MA83 NA14 ZA89 ZA91 ZB13

Claims (3)

[Claims] 1. A skin moisturizing topical composition comprising glycerin and urea. 2. The composition according to claim 1, further comprising a solvent for dissolving urea. 3. The composition according to claim 1, wherein the urea is present in an amount of from 10 to 30% by weight, based on the weight of the composition.