JP2001181174A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition with slight skin irritation without deteriorating deodorizing actions, antiseptic and sterilizing actions, blood circula tion promoting actions, etc. of a substance derived from Alpinia speciosa K. Schum. SOLUTION: This cosmetic composition is obtained by formulating a substance derived from Alpinia speciosa K. Schum and a substance derived from Glycyrrhiza glabra L. var. glandulifera Regel et Herder, has deodorizing actions, antiseptic and sterilizing actions, blood circulation promoting actions, etc. and is excellent in skin safety without imparting skin irritation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION A cosmetic composition comprising a substance derived from peach and a substance derived from licorice, that is, "at least one of peach extract and peach essential oil" and "licorice extract, glycyrrhizic acid and salts thereof. And at least one glycyrrhetinic acid derivative ". The present invention relates to a cosmetic composition having a deodorizing action, an antiseptic action, a bactericidal action, a blood circulation promoting action, etc., and excellent skin safety.

[0002]

2. Description of the Related Art Moon peach (Alpinia sp.)
eciosa K .; Schum or Tyringet:
Alpinia uraiensis "Zingiberaceae")
Is widely distributed mainly in tropical and subtropical areas south of southern Kyushu. Moon peach has cineol, D-camphor, α-pinene, β-pinene, ρ-cymene, terpinen-4-ol, linalool, limonene, sabinene, myrcene, γ-
It has been clarified that terpinene, piperitol, bornyl acetate, carvacrol, β-caryophyllene, α-humulene, nerolidol, and the like are contained (Okinawa Industry Research Laboratory Research Report No. 20, 1992).

The following are known techniques relating to moon peaches. Method of using moon peach as a fragrance
No. 6728), a method for preparing an essential oil component (JP-A-2-4)
No. 5597), an insect repellent and antibacterial substance obtained by dispersing moon peach essential oil in a solvent with a dispersant, and then performing a coating treatment capable of sustained release with a coating agent, and a bark and a paint containing the same (JP-A-5-201821, JP-A-5-202229), a composition comprising an extract of hibiscus, aloe and moon peach (JP-A-5-306210), cineole eucalyptus oil, moon peach essential oil, hiba oil and clove oil Agricultural fungicides (Japanese Patent Application Laid-Open No. 6-116111), polyolefin fiber sheets containing natural insect repellent fibers (Japanese Patent Application Laid-Open No. 7-289412), tatami floors using moon peach (Japanese Patent Application Laid-Open No. 8-93192), Deodorant and antioxidant containing moon peach powder, juice or solvent extract
No. 615), a wax pack impregnated with an extract of moon peach or the like (Japanese Patent Application Laid-Open No. 9-2962), a moon formed by kneading with a mixture of ginger or mint gum liquid, hinokitiol and alcohol. A method using peach (JP-A-9-124677) and a method for alleviating the symptoms of hay fever and allergy by spraying an extract of moon peach from a spray container and sucking the same (JP-A-10-330276). ,
An insect repellent fragrance (Japanese Unexamined Patent Publication No. 10-338609) in which the roots and leaf stems of moon peaches are dried, cut into small pieces, and wrapped with Japanese paper or cloth (Japanese Patent Application Laid-Open No. 10-338609), a pendant having an action of insect repellent, preservative, antibacterial, antioxidant and fragrance. , Brooches, earrings and rings (JP-A-11-15
No. 8079) and a method of easily obtaining an extract of moon peach leaf scent (Japanese Patent Application Laid-Open No. H11-199891).

[0004]

The components obtained from moon peach are used as insect repellents, antioxidants, antibacterial agents, deodorants, etc., but when the moon peach component comes into direct contact with human skin, It is known to induce erythema and edema of the skin, and there is a problem that the amount of the compound must be limited particularly when it is used in cosmetics. Although more than 20 types of components are extracted from moon peach, it is difficult to remove only the compound of interest from the mixture because of similar properties such as structure and solubility in solvents. Therefore, when a component obtained from moon peach is used as a cosmetic, it is necessary to reduce irritation to the skin.

On the other hand, components obtained from licorice are known to have an anti-inflammatory effect, and are widely used in cosmetics for the purpose of soothing or preventing skin inflammation. However, it is not known that a component obtained from licorice reduces or suppresses skin erythema and edema induced by a moon peach component.

The inventors of the present invention have conducted intensive studies in view of the above-mentioned circumstances, and as a result, it has been found that a composition comprising a substance derived from moon peach and a substance derived from licorice described below has a deodorizing effect inherent to the substance derived from moon peach. It is an object of the present invention to provide a means for alleviating skin irritation of a substance derived from moon peach and thereby suppressing the occurrence of erythema and edema of the skin without impairing the antiseptic / bactericidal action and blood circulation promoting action.

[0007]

That is, claim 1 of the present invention, which achieves the above object, is a cosmetic composition comprising a substance derived from moon peach and a substance derived from licorice. Claim 2
The cosmetic composition according to claim 1, wherein the moon peach-derived substance comprises at least one of moon peach extract and moon peach essential oil, and the licorice-derived substance comprises at least one of licorice extract, glycyrrhizic acid and salts thereof, and a glycyrrhetinic acid derivative. It is. Further, claim 3 is a cosmetic composition wherein the glycyrrhetinic acid derivative in claim 2 is glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhetinyl stearate, disodium 3-succinyloxyglycyrrhetinate or glycyrrhetinic acid monoglucuronide. Still further, in claim 4, the compounding amount of the moon peach-derived substance in claim 1 is 0.01 in terms of pure content based on the total amount of the composition.
-10% by weight, the compounding amount of the licorice-derived substance is 0.01 to
It is a cosmetic composition that is 1.0% by weight.

Hereinafter, the configuration of the present invention will be described in detail. As the raw material of the moon peach used in the present invention, a moon peach extract obtained by extracting the above-ground parts, roots or whole plants of the moon peach with a solvent, and a moon peach essential oil obtained by distilling the above-mentioned materials are applied as the raw materials.

Water is used as a solvent for obtaining the moon peach extract,
Methanol, ethanol, acetone, n-butanol,
Hexane, ethyl acetate, diethyl ether, dimethyl ether, chloroform, acetonitrile and the like can be used alone or in combination.

The conditions for extraction with a solvent are not particularly limited, but usually extraction at room temperature and with heat is preferred.
After extraction, it is filtered and concentrated to dryness to obtain a solution, paste,
It may be used as a powder. In many cases, it can be used as it is, but if necessary, purification treatment such as deodorization and decolorization may be added as long as the desired effect is not impaired.

There are three known methods for producing moon peach essential oil. That is, a water distillation method of heating the water in which the aerial part, roots or whole plant of the moon peach is soaked with an open flame or steam to extract essential oil together with steam, or steam distillation by blowing steam into the raw material charged in the still. The essential oil is allowed to accompany the steam, and then cooled and separated to collect the essential oil. The steam distillation method (direct steam distillation method), the raw material is placed on a grid, and the raw material and the steam are brought into contact with the steam from below. Then, there is a steam distillation method (indirect steam distillation method) in which the essential oil is distilled with accompanying steam, and cooled and separated to collect the essential oil, but any method may be used. In addition, as for the substance derived from moon peach, the weight obtained by removing water and the solvent from the extract or the distillate is defined as a pure content equivalent.

The licorice-derived substances used in the present invention are all known substances, and at least one of licorice extract, glycyrrhizic acid and its salts and glycyrrhetinic acid derivatives is applied.

The licorice extract is obtained by concentrating an aqueous extract of licorice root, and as the salts of glycyrrhizic acid, any of ammonium salt, potassium salt and sodium salt can be used. Further, the glycyrrhetinic acid derivative may be any of glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhetinyl stearate, disodium 3-succinyloxyglycyrrhetinate or monoglucuronide glycyrrhetinate. The licorice-derived substance is used in terms of pure content based on glycyrrhizic acid and glycyrrhetinic acid.

The compounding amount of the substance derived from moon peach and the substance derived from licorice used in the present invention is 0.01 to 10% by weight in terms of pure content, based on the total amount of the composition. The blending amount of the licorice-derived substance is preferably 0.01 to 2.0% by weight, and the blending ratio of the peach-derived substance to the licorice-derived substance is 1: 0.1 to It is preferably 1.

[0015] The dosage form of the cosmetic composition of the present invention in which the substance derived from moon peach and the substance derived from licorice are blended is arbitrary and is blended by a conventional method. For example, skin lotion, shaving lotion, milky lotion, skin cream, pack, powder, soap, face wash, hand soap,
It can be in the form of body soap, bath agent, deodorant, hair tonic, hair spray, shampoo, mascara, eye shadow, toothpaste and the like.

The form of the cosmetic composition of the present invention containing the substance derived from moon peach and the substance derived from licorice is optional, and is used as a solution, cream, paste, gel, foam, solid or powder. be able to.

According to the properties of the cosmetic composition to be designed, the desired effects of the cosmetic composition of the present invention are not impaired.
Moisturizers, sun protection agents, vitamins, plant and animal extracts,
Ingredients that can be roughly blended with the cosmetic composition, such as anti-inflammatory agents, whitening agents, vasodilators, astringents, cooling agents, hormonal agents and the like can be blended.

In the cosmetic composition of the present invention, a commonly known base component is used in accordance with the desired dosage form and form.
The composition can be widely used as long as the desired effect of the present invention is not impaired. That is, liquid fats and oils, solid fats and oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicones, various surfactants, sequestering agents, water-soluble polymers, thickeners, various Powder components, coloring agents, perfumes, water, and the like can be appropriately added to the cosmetic composition of the present invention as needed.

[0019]

Next, the present invention will be described in detail with reference to examples, but the scope of the present invention is not limited to these examples.

[Production Method 1: Preparation of Moon Water Extract by Water Extraction Method] Whole plant of Okinawa moon peach was ground by a mill. 1 kg of the pulverized product was put in a container, 10 L of water was added, the mixture was boiled for 5 hours, and the filtrate obtained by filtration under pressure was evaporated to dryness to obtain about 2 g of a light brown solid having a peculiar smell.

[Production Method 2: Preparation of Moon Peach Ethanol Extract by Ethanol Extraction] Okinawa whole moon peach was ground by a mill. 1 kg of the pulverized material was put in a container, 10 L of ethanol was added, the mixture was boiled for 1 hour, and the filtrate obtained by filtration was evaporated to dryness to obtain about 3 g of a light yellow-brown solid having a peculiar smell.

[Production method 3: Preparation of moon peach essential oil by steam distillation method] Okinawa moon peach whole plant was ground by a mill. Steam was blown into 5 kg of the pulverized product under normal pressure for 1 hour, and the steam was cooled to 4 ° C. to obtain a distillate. The mixture was kept at 4 ° C. for 2 hours, and separated into an essential oil layer and an aqueous layer.
g was obtained.

Example 1: Skin lotion weight% glycerin 10.0 xanthan gum 0.02 citric acid 0.01 sodium citrate 0.1 monoammonium glycyrrhizinate 0.01 moon peach essential oil 0.01 polyoxyethylene hydrogenated castor oil ( 60EO) 0.3 Make the total amount 100 with purified water.

Production method: The components (1) to (4) are added to the components and mixed, and the mixture is kept at 70 ° C. to form an aqueous phase. The components are dissolved by heating and mixed, and kept at 70 ° C. to form an oil phase. Add the water phase to the oil phase, mix and cool to produce the product.

Example 2: Deodorant cream weight% moon peach essential oil 3.0 behenyl alcohol 1.5 squalane 10.0 olive oil 3.0 stearic acid 2.0 beeswax 2.0 octyldodecyl myristate 3.5 polyoxyethylene cetyl Ether (20EO) 3.0 Glycerin monostearate 2.5 (10) Dipotassium glycyrrhizinate 0.5 (11) 1,3-butylene glycol 8.5 (12) Adjust the total amount to 100 with purified water.

Production method: Components are heated and mixed,
Keep at 70 ° C to make oil phase. The components (10) to (12) are dissolved by heating and mixed, and kept at 75 ° C. to form an aqueous phase. The water phase is added to the oil phase, emulsified and stirred while cooling to obtain a product.

Example 3: Acne Cream wt% Stearic Acid 15.0 Cetanol 3.0 Glycyrrhetinic Acid 0.5 Moon Peach Essential Oil 5.0 Glycerin Monostearate 2.0 Glycerin 5.0 Propylene Glycol 3.0 Hydroxide Potassium 1.5 Make the total amount 100 with purified water.

Production method: oil phase of components and components
After mixing, heating and dissolving each of the aqueous phases at 75 ° C. and mixing, an aqueous phase is added to the oil phase and then mixed to obtain a product.

Example 4: Milky lotion wt% moon peach ethanol extract 1.0 cetanol 2.0 squalane 5.0 olive oil 5.0 jojoba oil 5.0 glyceryl monostearate 2.5 polyoxyethylene cetyl ether (20E) .O) 3.0 polyoxyethylene sorbitan monooleate (20EO) 2.0 dipropylene glycol 1.0 (10) glycerin 2.0 (11) licorice extract (licorice licorice extract) 0.1 (12) ▼ Make the total amount 100 with purified water.

Production method: Components are heated and mixed,
Keep at 70 ° C to make oil phase. Ingredients ~ (12) are dissolved by heating and mixed, and kept at 75 ° C to obtain an aqueous phase. The water phase is added to the oil phase, emulsified and stirred while cooling to obtain a product.

Example 5: Hair rinse weight% Cetanol 3.0 Stearyltrimethylammonium chloride 1.0 Monthly peach essential oil 2.0 Glycyrrhizic acid 0.5 Glycerin 3.0 The total amount is adjusted to 100 with purified water.

Production method: Add the components to the components,
Heat to ° C. On the other hand, the components are mixed and dissolved. While the oil phase is being stirred, the previously prepared aqueous phase is gradually added to pre-emulsify, homogenized by adding a homomixer, and then cooled to obtain a product.

Example 6: Hand soap weight% palm oil fatty acid amidopropyl betaine solution 50.0 citric acid qs polyoxyethylene lanolin alcohol (100EO) 1.0 lauric acid 3.0 caustic potassium 0.5 propylene glycol 5 0.0 Monthly Tomizu Extract 5.0 Stearyl glycyrrhetinate 0.5 Adjust the total amount to 100 with purified water.

Production method: The components are heated and mixed at 50 to 70 ° C. and cooled to obtain a product.

Example 7: Bath agent weight% sodium bicarbonate 50.0 aloe powder 3.0 moon water extract 10.0 10.0 disodium 3-succinyloxyglycyrrhetinate 1.0 The total amount is adjusted to 100 with sodium sulfate.

Manufacturing method: The components (1) and (2) are uniformly mixed to obtain a product.

Example 8: Shampoo weight% sodium alkyl ether sulfate 18.0 coconut oil fatty acid diethanolamide 2.0 month peach essential oil 2.0 glycyrrhetinyl stearate 0.5 Make up to 100 with purified water.

Production method: The components (1) to (4) are added to the components,
Mix evenly to form a product.

Test Example 1: Skin primary irritation test: Example 1,
Comparative Examples 1, 2, 3, 4 in which licorice-derived substances were excluded from Examples 2, 3, 4, and Examples 1, 2, 3, and 4, and Examples 1, 2, 3, and 3
Comparative Example 5 from which a substance derived from moon peach and a substance derived from licorice were removed from 4
Rabbits with depilated back (6, 7, 8) were used as samples (3 per group)
A feather). The evaluation was made 24, 48, and 72 hours later according to the criteria shown in Table 1, and the average value of the skin irritation index relating to the occurrence of erythema and edema was obtained. Table 2 shows the evaluation results.

[0040]

[Table 1]

[0041]

[Table 2]

As shown in the results of the primary skin irritation test shown in Table 2, in Comparative Examples 1, 2, 3, and 4, clear erythema and edema were observed. However, in Examples 1, 2, 3, and 4, erythema and edema were not observed. From this, it was shown that the cosmetic composition comprising the substance derived from moon peach and the substance derived from licorice of the present invention does not have primary skin irritation.

Test Example 2: Skin Cumulative Irritation Test: Hartley guinea pigs (male, 5 per group) whose hair was removed from the flank once a day, 5 times a week, in Examples 1, 2, 3, 4 Comparative Examples 1 and 2, except that licorice-derived substances were removed from Examples 1, 2, 3, and 4.
2, 3, 4, and Comparative Examples 5, 6, 7, and 8 from Examples 1, 2, 3, and 4, in which the moon peach-derived substance and the licorice-derived substance were excluded.
5 mL / 8 cm ^{2 was} applied. Applying for 4 weeks
Hair removal was performed on the last application day of each week. The evaluation was performed on the day following the last day of each week according to the criteria shown in Table 1, and the average value of the skin irritation index relating to the occurrence of erythema and edema was determined. Table 3 shows the evaluation results.

[0044]

[Table 3]

As shown in the results of the skin cumulative irritation test shown in Table 3, in Comparative Examples 1, 2, 3, and 4, clear erythema and edema were observed. However, in Examples 1, 2, 3, 4 and Comparative Examples 5, 6, 7, and 8, erythema and edema were not observed. This indicates that the cosmetic composition comprising the substance derived from moon peach and the substance derived from licorice of the present invention does not have cumulative skin irritation.

Practical Test Example 1: Deodorizing action: In a healthy person (8 men and 2 women) of 20 to 55 years old, a licorice-derived substance was obtained from the body lotion of Example 2 and the body lotion of Example 2. As a sample, Comparative Example 2 in which the moon peach-derived substance and the licorice-derived substance were removed from the body lotion of Comparative Example 2 and Example 2, and about 1 g of body lotion was rubbed twice a day under each person's armpit. The deodorizing effect on the sides when each sample was used continuously for one week at different times was tested. The deodorizing effect was evaluated by self-report according to the following criteria. Table 4 shows the evaluation results.

：: Deodorizing effect is observed. Δ: Deodorizing effect is slightly observed. ×: No deodorizing effect was observed.

Practical test example 2: Bactericidal action: Acne cream of Example 3 and licorice-derived substance from acne cream of Example 3 as acne disease panelists (6 men and 4 women) of 15 to 20 years old Comparative Example 3 in which the peach-derived substance and the licorice-derived substance were removed from the acne cream of Example 3 except for the acne cream of Example 3, and about 0.5 g of acne twice a day was applied to each person's acne site. When the cream for use was rubbed and each sample was used continuously for four weeks with a different period, the effect of eliminating and improving acne skin by a bactericidal action was tested. The effect was evaluated by self-report according to the following criteria. Table 4 shows the evaluation results.

：: Improvement in acne appearance was observed. Δ: Slight improvement in acne appearance was observed. X: No improvement in acne appearance was observed at all.

Practical Test Example 3: Blood circulation promoting action: 20-35
Comparative Example 4 in which a licorice-derived substance was removed from Example 4 and Example 4 for healthy healthy persons (8 males and 2 females), and a comparison in which the peach and licorice-derived substances were removed from Example 4 Using Example 8 as a sample, about 1 g was applied to the cheek, and the subject himself
After a 30-minute massage, the temperature change on the skin surface after a 30-minute rest was measured by thermography (Nippon Avi).
nics). Table 4 shows the evaluation results.

：: Skin surface temperature rises, and blood circulation promoting effect is observed. Δ: Slight blood circulation promoting effect is observed. ×: No blood circulation promoting effect was observed.

Practical Test Example 4: Skin irritation test: 20-35
In healthy humans (five males and five females), comparative examples 2, 3, and 4 of licorice-derived substances from Examples 2, 3, and 4, and Examples 2, 3, and 4 From Comparative Examples 6, 7, and 8 in which the peach-derived substance and the licorice-derived substance were removed from
The number of people who developed erythema / edema when 1 g was applied to the lower arm of the left hand once a day for a month was counted. At this time, if erythema / edema occurred once, the subsequent application was stopped. Table 4 shows the results.

：: Erythema / edema is observed. Δ: Erythema / edema is slightly observed. X: Erythema and edema are not observed at all.

[0054]

[Table 4]

As shown in Table 4, as a result of the deodorizing test, a better deodorizing effect was observed in Example 2 than in Comparative Example 6. In addition, as a result of the sterilization test, Example 3 was compared with Comparative Example 7.
Had a good bactericidal action. Furthermore, as a result of the blood circulation promoting test, a better blood circulation promoting effect was observed in Example 4 as compared with Comparative Example 8. On the other hand, in Examples 2, 3, and 4, the occurrence of marked erythema and edema was significantly suppressed as compared with Comparative Examples 2, 3, and 4.

Thus, the composition of the present invention comprising a substance derived from moon peach and a substance derived from licorice can be used alone without impairing the deodorizing action, preservative / bactericidal action, blood circulation promoting action and the like. It was confirmed that the composition was extremely safe and less irritating to the skin than when it was blended.

[0057]

As described above in detail, the cosmetic composition comprising a substance derived from moon peach and a substance derived from licorice according to the present invention has a deodorizing effect, preservative and sterilization inherent in the substance derived from moon peach. A composition that reduces the irritation of the peach-derived substance to the skin and thus suppresses the occurrence of erythema and edema of the skin, as compared to cosmetics and the like that contain only the peach-derived substance without impairing the action and blood circulation promoting action It has excellent skin safety.

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Hiroshi Iwase 5-141, Kamihama-cho, Tsu-shi, Mie Prefecture Hiroki Co., Ltd. (72) Inventor Hiroyuki Takai 3-9-1, Uchikanda 3-9-3, Uchikanda, Chiyoda-ku, Tokyo Co., Ltd. (72) Inventor Yoshikazu Hayata 3-9-1, Uchikanda, Chiyoda-ku, Tokyo Hiroki, Inc. (72) Inventor Mamoru Abe 2-17-9, Wakabayashi, Setagaya-ku, Tokyo Eva Cosmetics (72) Inventor Atsushi Morokita 18 Nakijin, Nakijin Village, Okinawa Prefecture 2 Yumejin Limited company F term (reference) 4C083 AA082 AA111 AA121 AA122 AB032 AB312 AC022 AC072 AC102 AC122 AC172 AC182 AC242 AC302 AC352 AC422 AC432 AC692 AC712 AC782 AD352 AD512 AD531 AD532 CC01 CC04 CC05 CC23 CC25 CC38 CC39 DD23 DD31 EE10 EE12 EE14 EE18 4C088 AB60 AB81 AC02 AC11 BA09 BA10 CA03 MA08 MA63 ZA89

Claims (4)

[Claims] 1. A cosmetic composition comprising a substance derived from moon peach and a substance derived from licorice. 2. The moon peach-derived substance comprises at least one of moon peach extract and moon peach essential oil, and the licorice-derived substance is a licorice extract,
The cosmetic composition according to claim 1, comprising at least one of glycyrrhizic acid and salts thereof and a glycyrrhetic acid derivative. 3. The cosmetic composition according to claim 2, wherein the glycyrrhetinic acid derivative is glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhetinyl stearate, disodium 3-succinyloxyglycyrrhetinate or monoglucuronide glycyrrhetinate. 4. The amount of the substance derived from moon peach is 0.01 to 10% by weight in terms of pure content based on the total amount of the composition, and the amount of the substance derived from licorice is 0.01 to 1.0% by weight. The cosmetic composition according to claim 1, which is: