JP2001009021A - Packing material to defective part or cavity part of bone - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a packing material which puts the defective or gap part of a bone or a state extremely approximate to the properties, such as strength and modulus of elasticity intrinsic to the bone, is inexpensive and practicable and does not adversely affect the living body after packing. SOLUTION: At least either of a calcium compound, such as calcium carbonate of >=50 μm to <=1 mm in size, or a compound 12 containing calcium and phosphorus, such as apatite carbonate are dispersed into cement 11 for the living body prepared by forming a calcium phosphate compound to a paste form by a curing liquid at 5 to 900 vol.% of 100 vol.% cement for the living body. The calcium compound or the compound containing the calcium and the phosphorus has any of a granular, fibrous or planar form or their mixed shape.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a filler used for filling a defective or void part of a bone and restoring the same in a medical department, dentistry or the like.

[0002]

2. Description of the Related Art In the past, when bones have defects or voids in the medical fields such as dentistry, orthopedics, and surgery, bone fillers using various materials such as polymers and ceramics have been used. Among the ceramic materials, a biological cement prepared by preparing a calcium phosphate compound into a paste with a hardening liquid is known. The biocement can be freely changed into a shape such as a defective portion, and after filling the defective portion or the like, it changes into apatite. The changed apatite has excellent biocompatibility and has the property of forming new bone around the filler. After the biological cement hardens in the living body and changes to apatite, extremely fine pores are formed in the hardened body.

[0003]

However, the pores inside the cured body are not large enough to allow bone cells and the like having a role of forming new bone to enter into the pores and form new bone. Therefore, new bone is not sufficiently formed in the cured body formed by converting the biocement into apatite, and the physical properties of the portion filled with the biocement are different from the physical properties such as the original strength and elastic modulus of the bone. However, it is also fragile and may cause fractures, etc., and there is a point to be improved. An object of the present invention is to provide a filler for a defective portion or a void portion of a bone, which can be brought into a state very similar to physical properties such as the inherent strength and elastic modulus of the bone. It is another object of the present invention to provide a filler which is inexpensive and practical, has no adverse effect on the living body after filling, and is used for filling bone defects or voids. Still another object of the present invention is to provide a filler for a bone defect or void having a component in which a compound to be eluted can be used for new bone formation.

[0004]

The invention according to claim 1 is
As shown in FIG. 1A, a biological cement 11 in which a calcium phosphate compound is prepared in a paste form using a hardening liquid.
In addition, one or both of a calcium compound having a size of 50 μm or more and 1 mm or less or a compound 12 containing calcium and phosphorus is 5 to 100% by volume of the biocement.
It is a filler 10 for a bone defect or void that is dispersed by 900% by volume. In the invention according to claim 1, after the paste in which the compound is dispersed is filled into a bone defect or the like in a living body, the calcium compound or the compound containing calcium and phosphorus as shown in FIG. 12 is dissolved in the living body, and the portion where the compound 12 is dissolved becomes the pore 16. The size of the pores 16 is 50 μm or more and 1 mm or less corresponding to the size of the compound 12, where bone cells and the like enter, and new bone 17 is formed in the pores 16. When the size of the compound 12 is less than 50 μm, penetration of bone cells into the pores 16 becomes difficult, and when it exceeds 1 mm, bone formation in the pores 16 becomes insufficient. From the viewpoint of bone formation in the pores 16, the preferred size of the compound 12 is 100 μm.
m or more and 0.5 mm or less. In order for the bone to be formed to the inside of the biomedical cement, it is preferable that the pores 16 are sufficiently communicated with each other. When the dispersion ratio of the compound 12 in the biocement is less than 5% by volume, the pores 16 are difficult to communicate with each other, and the new bone 17 is not sufficiently formed inside the filler 10; The strength of No. 11 is insufficient, which is not preferable. The preferable dispersion ratio of the compound 12 depends on the shape of the compound 12, and when the compound 12 is granular, it is 10 to 900% by volume, more preferably 20 to 800% by volume. When the compound 12 is fibrous or plate-like, it is preferably 10
~ 500% by volume.

[0005]

Embodiments of the present invention will be described with reference to the drawings. As shown in FIG. 1A, the filler 10 of the present invention is constituted by dispersing one or both of a calcium compound and a compound 12 containing calcium and phosphorus in a cement 11 for living body. That is, the filler 10 of the present invention is:
The case where only the calcium compound or only the compound containing calcium and phosphorus is dispersed in the biocement 11 and the case where the calcium compound and the compound containing calcium and phosphorus are respectively dispersed in the biocement 11 including. The cement for living body 11 is prepared by mixing a powdered calcium phosphate compound and a hardening liquid into a paste.

An example of these is as follows. That is, the calcium phosphate compound contains α-type tribasic calcium phosphate (hereinafter referred to as α-TCP), quaternary calcium phosphate (hereinafter referred to as TeCP), or the like as a main component. Specifically, as the calcium phosphate compound, α-TCP or TeCP alone or a mixture thereof, a mixture of α-TCP and dicalcium phosphate (hereinafter, referred to as DCPD), α-TCP, DCPD and monocalcium phosphate (hereinafter, MCPM) Mixture of TeCP and DC
A mixture of PD, a mixture of TeCP, DCPD and MCPM, and a mixture of α-TCP, TeCP and DCP are exemplified. Examples of the curing liquid include water, an aqueous solution in which an organic acid is dissolved, and an aqueous solution in which water-soluble salts are dissolved. The aqueous solution in which the organic acid is dissolved includes polyacrylic acid, citric acid, malic acid or a mixture thereof, and the aqueous solution in which the water-soluble salts are dissolved includes sodium chloride, sodium chondroitin, sodium succinate, sodium lactate or these. There is a mixture of This biological cement 1
The compounding of No. 1 is preferably a calcium phosphate compound: hardening liquid = 2.0 to 5.0: 1.0 by weight ratio.

[0007] Examples of the calcium compound include calcium carbonate, calcium sulfate, calcium lactate, calcium alginate and calcium chloride. One or more of these calcium compounds are dispersed in the biocement. Also, as a compound containing calcium and phosphorus,
Examples thereof include calcium phosphate compounds having high solubility in a living body such as carbonate apatite, carbonate apatite, tricalcium phosphate, calcium pyrophosphate and calcium hydrogen phosphate. One or two or more of these compounds containing calcium and phosphorus are dispersed in the cement for living body. The calcium compound or the compound containing calcium and phosphorus has a granular, fibrous, or plate-like shape, or a mixture thereof.

A reagent having these shapes can be selected from commercially available reagents and used. on the other hand,
When producing compounds in these shapes, for example, when producing granules, a method of adding water to a calcium compound or a compound containing calcium and phosphorus to prepare a slurry, and spraying the slurry to a spray drier. It is manufactured by In the case of producing a fibrous material, for example, in the case of a compound containing calcium and phosphorus, the raw material containing calcium phosphate is used in a Ca / P molar ratio of 0.6 to 0.6.
The reaction can be carried out at a ratio of 1.7, followed by autoclaving. When manufacturing in plate form,
For example, in the case of a compound containing calcium and phosphorus, Ca / P
It is manufactured by a method of drying a compound having a molar ratio of 1.

As shown in FIG. 1B, in this embodiment, a filler 10 is filled in a defective portion 14 of a bone 13. The biological cement 11 of the filler 10 filled in the living body is about 4
It changes to apatite 11a (Ca ₅ (PO ₄ ) ₃ OH) in about a week. On the other hand, Compound 12
It elutes from the surface of the filler 10 into the living body in about a year. When the compound 12 is eluted, the portion where the compound 12 has been dispersed becomes the pore 16, and bone cells and the like enter into the pore 16 to form a new bone 17.

[0010]

As described above, since the filler of the present invention is constituted by dispersing one or both of a calcium compound and a compound containing calcium and phosphorus in a cement for living body, it can be applied to a bone defect or the like. After filling, the compound elutes to form pores, ions eluted from the compound become inorganic components of the new bone, and new bone is formed in the pores by the invading bone cells. As a result, a defect or the like can be repaired in a state very similar to the physical properties of the original bone.
Moreover, it is inexpensive and practical, and does not adversely affect the living body after filling.

[Brief description of the drawings]

FIG. 1A is a schematic view of a filler of the present invention. (B) A schematic diagram of a state where the filler of the present invention has been filled into a bone defect and solidified.

[Explanation of symbols]

Reference Signs List 10 filler 11 biocement 12 calcium compound or compound containing calcium and phosphorus

 ────────────────────────────────────────────────── ─── Continued on the front page F term (reference) 4C081 AB04 AB06 AC04 BA13 CA082 CE11 CF011 CF021 CF21 DA04 DA11 DA13 DB02 DB05 DC12 4C089 AA06 AA10 BA03 BA08 BA10 BA16 BA18 BC05 BE16 CA03 CA06 CA07

Claims (4)

[Claims] 1. A biological cement (11) in which a calcium phosphate compound is prepared in a paste form by using a hardening liquid, a calcium compound having a size of 50 μm or more and 1 mm or less or a compound containing calcium and phosphorus (12) or both. Is a filler for bone defects or voids in which 5 to 900% by volume is dispersed with respect to 100% by volume of the biocement. 2. The method according to claim 1, wherein the calcium compound or the compound (12) containing calcium and phosphorus has a granular, fibrous or plate-like shape or a mixture thereof. Filler. 3. The calcium compound is one or two selected from the group consisting of calcium carbonate, calcium sulfate, calcium lactate, calcium alginate and calcium chloride.
The filler according to claim 1 or 2, which is a compound of at least one kind. 4. The compound containing calcium and phosphorus is carbonate apatite, carbonate apatite, tricalcium phosphate,
3. The filler for a bone defect or void according to claim 1 or 2, which is one or more compounds selected from the group consisting of calcium pyrophosphate and calcium hydrogen phosphate.