JP2000302678A - Hair activity by isoflavone derived from soybean - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve a male depilation by keeping hormone balance in the body by administration of female hormone so as to adjust rise in reactivity of male hormone since the cause of male depilation is considered to be lessening of papilla and noncontinuation of the growth period in a hair period but not reduction in cell growth of hair-mother cells. SOLUTION: Isoflavone in a hypocotyl of soybean is considered to be a chemical substance to act as a phytoestrogen due to structural similarity to female hormone (estrogen). Daidzein and genistein are bonded to an estrogen receptor and show an estrogen action (agonist) and an antiestrogen action (antagonist) according to concentration. It is understood that 17β estradiol being a representative estrogen contains hydroxy groups at both ends and a flat ring structure common to isoflavonoid. A proper amount of isoflavone (phytoestrogen) derived from a hypocotyl of soybean structurally similar to the female hormone (estrogen) is orally administered so as to prevent and improve male depilation or white hair.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

FIELD OF THE INVENTION The present invention is based on the assumption that the cause of gray hair and male pattern hair loss on hair is due to the internal balance of male and female hormones, and how to adjust the internal balance of male and female hormones. We searched for it and focused on isoflavones derived from soy. Oral ingestion of this isoflavone regulates hormonal balance in the body and helps prevent and activate gray hair and male pattern hair loss.

[0002]

2. Description of the Related Art Most of the hair tonics and hair restorers currently on the market are mainly composed of components that promote blood circulation. I think minoxidil, which has recently been talked about, is one such substance. In this way, most products are only sprinkled on the head to activate the hair, and there are no hair growth and hair growth products that are taken orally due to hormonal balance in the body.

[0003]

The general hair loss phenomenon is as follows.
Male pattern baldness and alopecia areata. In alopecia areata or drug-induced alopecia, the growth of the hair matrix stops cell growth for some reason, so the hair shaft elongates rapidly and loses hair by changing to telogen hair. . In contrast, male pattern hair loss reduces the thickness and length of hair as the hair cycle increases. This is due to the smaller hair follicles and the shorter anagen of the hair cycle. So,
Hair thinning may be closer to the body than hair loss.

[0004] Male pattern hair loss progresses with age, and it is common to thin the hair from the hairline of the bangs to the top of the head. A study by Dr. Hamilton in the United States has shown that male hormones may be involved in the progression of male pattern hair loss. He found no male pattern hair loss in men castrated or before castration. When the testicles are removed by castration, they can no longer make male hormones. Then, when male hormones were administered to castrated men, hair loss began to be seen only in men who were predisposed to male pattern hair loss in the family. Furthermore, even if the treatment was stopped halfway, alopecia symptoms that had begun once did not progress, but did not return to their original state. This means that male pattern hair loss is an irreversible change that depends on genetic factors and male hormones.

[0005] The relationship between hair development and male hormones is that males develop testicles during puberty and begin to make male hormones actively. By the action of this male hormone, beard, chest hair,
Hair characteristic of men, such as shin hair, develops. By the way, men and women develop side hair and pubic hair during puberty, and male hormones are also involved in the growth of these hairs. Androgens regulate the expression of various genes by binding to their receptors, the androgen receptors.
Patients with testicular feminization who lack the androgen receptor do not develop beards, chest hairs, or side and pubic hair. In other words, if the information on male hormones is not transmitted properly, the genetic programs that develop these hairs will not work properly. The levels of androgens in the blood do not differ between men with androgenetic alopecia and those who do not. The concentration of male hormones in the blood is not due to the increase in hair thinning due to the large number of male hormones, but due to individual differences in the sensitivity to male hormones due to genetic factors or the genetic program after receiving male hormones. Even if they are the same, male pattern hair loss may or may not occur. In the scalp hair, between the forehead and occipital hair follicles, the amount of androgen receptor and 5α-reductase are relatively high in papilla cells, but scarcely in hair mother cells. Therefore, androgens do not act directly on hair cells to alter the rate of hair growth or the length of the hair cycle, but are first taken up by papillae and cause some changes, which in turn act on hair cells. It seems that.
It is presumed that male hormones cause hair thinning by altering the secretion of growth factors of papilla cells. Sebaceous glands that secrete sebum are also developed by male hormones. As the hair follicles and sebaceous glands age, they become much more responsive to androgens, and the levels of androgens rise, rather than puberty, when these changes (male hair loss or gray hair) ) Will appear. Then,
Does stopping male hormones prevent male pattern hair loss? As a matter of principle, male hormones are deeply involved in the development and maintenance of male-specific functions, so side effects are a problem.

Also, as a phenomenon peculiar to women, hair may come off three to four months after giving birth to a baby. This is called postpartum alopecia and is due to the effects of female hormones. Female hormones work to prolong the hair cycle. Since female hormones are continuously secreted during pregnancy, hair follicles that would otherwise end the hair cycle and enter into a telogen are also kept in anagen.
When female hormone levels drop after giving birth, these hair follicles go into a telogen, causing a large amount of hair to fall off at one time. It is thought that male pattern hair loss is not due to a decrease in cell proliferation of hair matrix cells, but to a decrease in papillae and a lack of sustained anagen during the hair cycle. In order to achieve this, the challenge is to maintain female hormonal balance by administering female hormones that work to prolong the hair cycle, and to resolve male pattern hair loss.

[0007]

[Means for Solving the Problems] The present invention relates to hair activity against male pattern hair loss and gray hair by oral administration of female hormones, but it is difficult to obtain female hormones because they are not sold in general stores. is. We focused on isoflavones derived from the hypocotyl of soybeans. Isoflavones have been shown to be effective in preventing and treating menopause and osteoporosis in women due to a decrease in female hormones (estrogens). Isoflavones are thought to be chemicals that act as phytoestrogens in soybeans due to their structural similarity to the female hormone (estrogens). d
Aidzein and genistin bind to estrogen receptor and show estrogen action (agonist) or anti-estrogen action (antagonist) depending on the concentration. It can be seen that 17β estradiol, a typical estrogen, has the same hydroxyl group at both ends and a flat cyclic structure as isoflavonoids. The isoflavone (phytoestrogen) derived from the hypocotyl of soybean, which is structurally similar to this female hormone (estrogen), is taken orally in an appropriate amount for the purpose of male pattern hair loss or hair activity against gray hair.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The isoflavone derived from the hypocotyl of soybean of the present invention can be prepared by converting a soybean food containing phytoestrogens as an active ingredient into a foodstuff known per se or a food ingredient, a pharmaceutical carrier or an excipient by a method known per se. Together, it can be a food that activates hair. The food or food ingredient to be used is not particularly limited, and can be appropriately selected by those skilled in the art according to the intended use of hair activity and the specific use of hair loss prevention. In addition, the form of hair activity and hair loss prevention is not particularly limited, and can be made into various individuals and shapes depending on the specific application. In order to exert the effect of the present invention on the hair activity and the prevention of hair loss, it is particularly important to commercialize the soybean hypocotyl derived isoflavones from the blending ratio of daily soybeans. . The method of ingestion depends on oral intake. When orally ingesting isoflavones derived from soy hypocotyls containing phytoestrogens as an active ingredient, 40 m / day as an active ingredient for adults
By taking this in the form of g-200mg, divided into one or several times a day, the desired effect can be achieved without side effects.

[0009]

EXAMPLE The isoflavone derived from the hypocotyl of soybean of the present invention was
We tried to commercialize it by blending 100mg in 10 tablets. The shape was a tablet tablet. As other food ingredients,
Sesame mineral and amino acid were blended. The male-type hair removal activator commercialized in this way was asked to take orally by a tennis player of a 23-year-old decup player,
I took about a grain. His hair condition was always the worst, and his frontal hair was thinning, because he was sweating and wearing a hat during an outdoor game or practice. As a result of continuing to drink for 4 months, hair growth began to appear on the frontal region.

[0010]

[Effects of the Invention] In the current research, drugs that inhibit the activity of type II 5α reductase, which is mainly involved in beard development and male pattern hair loss, are being advanced. The study suggests that hair activity is due to the relationship between male and female hormones. For example, female hormones are used to treat prostate cancer, and it was originally thought to be due to estrogenic effects. Inhibiting 5α reductase reductase, which produces the male hormone testosterone,
Furthermore, it was verified that various actions such as reduction of free radical lipid peroxide are likely to be effective in combination. Many of those patients have hair activity phenomena. Also, as a phenomenon peculiar to women, hair may fall out three to four months after giving birth to a baby. This is called postpartum alopecia and is due to the effects of female hormones. Female hormones work to prolong the hair cycle. Since female hormones are continuously secreted during pregnancy, hair follicles that would otherwise end the hair cycle and enter into a telogen are also kept in anagen.
When female hormone levels drop after giving birth, these hair follicles go into a telogen, causing a large amount of hair to fall off at one time. Oral ingestion of isoflavones from soybean hypocotyls is considered to be a chemical substance that acts as a phytoestrogen due to its structural similarity to the female hormone (estrogen), and is expected to be effective in male pattern hair loss.

Claims (1)

[Claims] 1. Hair activity by oral ingestion of isoflavones derived from soybean.