JP2000109417A - Cosmetic for improving somber color - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition for improving someber color which shows an excellent dark color improving effect and is effective on aging change and useful as a cosmetic or the like by including an elastase activity inhibitor and a melanin production suppressant. SOLUTION: This cosmetic composition is obtained by mixing (A) an elastase activity inhibitor, suitably a soybean protein and/or an essence of Engelhardtia chrysolepis H, with (B) a melanin production suppressant, suitably one or more than two kinds selected from arbutin, vitamin C, a vitamin C derivative, an essence of royal jelly and an essence of mulberry bark. Further, it is favorable that the components A and B are contained, for example, in amounts of about 0.01-10 wt.% and about 0.01-10 wt.%, respectively, and a hydrocarbon, e.g. Vaseline or the like, an ester, e.g. jojoba oil or the like, a triglyceride, e.g. beef tallow or the like, or the like is additionally added.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for external use on the skin such as cosmetics which is useful for improving troubles associated with aging such as dullness.

[0002]

2. Description of the Related Art The beauty of the skin changes with the age. After the middle age, wrinkles increase and dullness increases with the age, and the beauty of the past disappears. Among them, dullness is said to be a synergistic result of overproduction of melanin and morphological change of skin. In response to such age-related changes in appearance, people have been striving to reduce this change since ancient times and have developed various technologies. Such technologies include retinol,
Wrinkle removal technology using vitamin A such as retinoin and vitamin A acid, light damage mitigation technology using magnesium phosphate ascorbate, collagen fiber using collagen cross-linking inhibitor using aminoethyl compounds, extracts of plants of the family Saxifragaceae, etc. For suppressing the disappearance of elasticity. However, although these techniques do work, they are not quite satisfactory,
In addition, in the case of vitamins A and the like, undesired effects such as excessive symptoms may be exhibited, and the amount of vitamin A used is limited. That is, the development of a composition that has a further excellent dullness-improving effect and suppresses such aging changes has been desired.

On the other hand, it has not been known at all that skin external preparations contain an elastase activity inhibitor and a melanin production inhibitor, and further, a skin external preparation containing such components is excellent in skin conditioning. It had no effect, nor was it known to be effective against age-related changes.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and has an excellent dullness-improving effect and is effective against aging. It is an object to provide a composition.

[0005]

In view of such circumstances, the present inventors have sought to provide a skin external preparation such as a cosmetic, which has an excellent skin conditioning effect and is effective against aging. As a result of repeated research efforts, they have found such an effect in an external preparation for skin containing an elastase activity inhibitor and a melanin production inhibitor, and have completed the invention. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS (1) Elastase activity inhibitor which is an essential component of the present invention The external composition for skin of the present invention contains an elastase activity inhibitor as an essential component. The elastase activity inhibitor referred to in the present invention is 2 mM elastase substrate as a substrate solution,
0.1 ml of a 0.5 M sodium chloride buffer (pH 7.5) containing 0.1 M HEPES was used, and 50 ml of a human leucocyte elastase (Sigma, 1 unit) was used as an enzyme solution in a 50 ml HEPES sodium chloride buffer (pH 7). 1.8 ml of the solution dissolved in .5), 0.1 ml of the sample was added thereto, and after standing at room temperature for 1 hour, elastase activity was measured as an absorbance at 405 nm. 0.05% or less and a 50% inhibitory concentration of 0.5% or less, such as an inhibitory expression concentration of 0.01% and a 50% inhibitory concentration. Is 0.1% soybean protein (Elhibin; manufactured by Pentafarm Co., Ltd.) and Kouki having an inhibitory expression concentration of 0.001% and a 50% inhibitory concentration of 0.01% Kouki Extract BG (1,3-butanediol extract of leaves of Kouki;
(Maruzen Pharmaceutical Co., Ltd.) can be preferably exemplified. The essence referred to in the present invention is a plant itself, a processed product obtained by drying and pulverizing the plant, an alcohol, an ester, a halogenated hydrocarbon, a polyhydric alcohol, Extracts obtained by adding solvents such as ketones and water,
This is a generic term for the solvent-extracted product of the extract obtained by removing the solvent from the extract, and the fractionated product thereof. In the external composition for skin of the present invention, these elastase activity inhibitors can be contained alone or in combination of several kinds. The preferred content of these elastase activity inhibitors in the skin external composition of the present invention is 0.01 to 10% by weight,
More preferably, it is 0.05 to 5% by weight.

(2) Melanin production inhibitor which is an essential component of the present invention The melanin production inhibitor referred to in the present invention means a substance which has no significant cytotoxicity and suppresses the production of melanin. Shows that in screening using melanoma B16 cells, when the concentration of the sample is 0.1% or less in final concentration, the cytotoxicity is so low that it is not significantly different from the control,
It means a substance that significantly suppresses the production of melanin. Such substances include, for example, derivatives thereof such as arbutin, glycosides and salts, derivatives thereof such as vitamin C, esters, ethers, glycosides and salts, essence of royal jelly and essence of soybean, and essence of birch ,
Examples thereof include phenolic substances such as tannin and resorcin and derivatives thereof. Of these, particularly preferred are:
One or more selected from arbutin, vitamin C, a derivative of vitamin C, royal jelly essence and soybean essence. This is because such a substance well suppresses the production of melanin, which is particularly involved in dullness and the like. In the skin external composition of the present invention, the preferred content of the melanin production inhibitor is 0.01
10 to 10% by weight, more preferably 0.05 to 5% by weight.

(3) The composition for external use of the skin of the present invention The composition for external use of the skin of the present invention is characterized by containing the above elastase activity inhibitor and melanin production inhibitor. Examples of the composition for external use of the skin of the present invention include cosmetics and antifungal agents, anti-inflammatory agents, external dermatological drugs such as steroid agents, and among them, it is particularly preferable to apply the composition to cosmetics.
Above all, because it can suppress skin changes due to aging changes such as loss of flexibility, improve dullness due to aging, and keep skin beautiful without dullness, dullness aimed at improving dullness and suppressing deterioration It is particularly preferable to use as cosmetics for cosmetics. The composition for external use on the skin of the present invention may contain, in addition to the above essential components, optional components usually used in the composition for external use on the skin. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, tallow, triglycerides such as olive oil, cetanol,
Higher alcohols such as oleyl alcohol, fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric interfaces Activators, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, pigments, powders and the like can be preferably exemplified. Among these optional components, particularly preferred are substances such as placenta extract, royal jelly, glycogen and the like which activate cells, sulfated alginic acid and physiologically acceptable salts thereof, and collagen such as essence of the root of Bacuga. It is a component that promotes synthesis, or a peroxide generation inhibitor such as mint essence, sage essence, rosemary essence, ginseng essence, and gougon essence. These cell activating components, collagen synthesis promoters, and peroxide production inhibitors are preferably contained in a total amount of about 0.01 to 1% by weight. By treating these components according to a conventional method, the composition for external use on skin of the present invention can be produced.

[0009]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited to only these Examples.

<Examples 1 to 6> Lotions were prepared according to the following formulations. That is, the ingredients were stirred at room temperature and solubilized to obtain a lotion. 1,3-butanediol 5 parts by weight Glycerin 3 parts by weight Ethanol 10 parts by weight Melanin production inhibitor * 1 part by weight Elastase activity inhibitor * 1 part by weight Methyl paraben 0.2 part by weight POE (60) hardened castor oil 0.1 part by weight 79.7 parts by weight of water * See Table 1 for details

[0011]

[Table 1]

<Example 7> Brown guinea pig (30 weeks old)
The dullness improvement of the lotions of Examples 1 to 6 was examined using a dullness model using. That is, the back of a group of three brown guinea pigs was shaved and exposed to ultraviolet rays of 0.5 × MED (minimum erythema concentration) for 5 days to prepare a dull model.
An administration site of 2 cm × 2 cm on the back was provided, and the sample was administered at 0.01 ml / time / day, 5 times / week for 8 weeks. Comparative Example 1 was obtained by substituting erhibin of Example 1 with water, Comparative Example 2 was obtained by substituting the essence of Sohakuhumi of Example 1 with water, and Comparative Example 3 was obtained by replacing the essence of Souhakuhhi of Example 2 with water. Comparative Example 4 was obtained by replacing erhibin of Example 3 with water, and Comparative Example 5 was obtained by replacing erhibin of Example 5 with water. In the control example, the essence of Elhibin and Sour pork in Example 1 was replaced with water.
The effect of improving dullness was as follows: 24 hours after the last administration, ++: markedly improved, +:
Clear improvement, ±: slight improvement,-: judgment was made for each animal on the basis of no improvement. Table 2 shows the results as the number of appearance cases. This shows that the lotion, which is a composition for external use on the skin of the present invention, has an excellent effect of improving dullness.

[0013]

[Table 2]

Example 8 A lotion was prepared according to the following formulation. That is, the ingredients were stirred at room temperature and solubilized to obtain a lotion. 1,3-butanediol 5 parts by weight Glycerin 3 parts by weight Ethanol 10 parts by weight Sulfated sodium alginate 0.1 part by weight Bakgacon essence 0.1 parts by weight Elhibin 0.5 parts by weight Kouki extract BG 0.5 parts by weight Plastic Center extract 0.1 parts by weight Sour bean essence 0.5 parts by weight Glycogen 0.1 parts by weight Royal jelly 0.5 parts by weight Methyl paraben 0.2 parts by weight POE (60) hardened castor oil 0.1 parts by weight Parts by weight Ginseng essence 0.1 parts by weight Birch essence 0.1 parts by weight Water 79 parts by weight

<Example 9> A woman over 50 years old,
A total of 30 panelists, a group of panelists suffering from dull skin, gathered a total of 30 persons, and applied the lotion of Comparative Example 6 in which the essence of Souhakuh and the royal jelly of the lotion of Example 6 and Example 8 were replaced with water. Comparative Example 7 in which Elhibin and Kouki Extract BG in Example 8 were replaced with water was evaluated for its dullness-improving effect. These lotions are used twice a day, morning and evening for 8 weeks, and the improvement of dullness of the skin is ++: marked improvement, +: obvious improvement, ±: slight improvement,-: standard without improvement I was evaluated. The results are shown in Table 3 as the number of appearance cases. This shows that the cosmetics of the present invention are excellent in the effect of improving dullness and making the skin healthy by improving the dullness on the skin in which dullness has accumulated due to aging changes.

[0016]

[Table 3]

Example 10 According to the following formulation,
A cream was made. That is, each of the components (a), (b), (c), and (d) are heated to 70 ° C., (a) and (b) are mixed, kneaded well, and the mixture is diluted by adding (c), and gradually added and emulsified. After stirring and cooling, a cream was obtained. A 70% maltose aqueous solution 5 parts by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methyl paraben 0.2 parts by weight b Triglycerin diisostearate 4 parts by weight Sorbitan sesquiolate 0.5 parts by weight C Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight Glyceryl triisooctanoate 5 parts by weight D water 55.3 parts by weight Sulfated sodium alginate 0.1 part by weight Essence of bacgacone 0.1 part by weight Elhibin 0.5 part by weight Kouki extract BG 0. 1 part by weight Placenta extract 0.1 part by weight Glycogen 0.1 part by weight Royal jelly 0.5 part by weight Ginseng essence 0.1 part by weight Ougon essence 0.1 part by weight Birch essence 0.1 part by weight Sohakuhi essence 0.1 parts by weight Butyne 0.1 part by weight

<Example 11> According to the following formulation,
A cream was made. That is, each of the components (a), (b), (c), and (d) are heated to 70 ° C., (a) and (b) are mixed, kneaded well, and the mixture is diluted by adding (c), and gradually added and emulsified. After stirring and cooling, a cream was obtained. A 70% maltose aqueous solution 5 parts by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methyl paraben 0.2 parts by weight b Triglycerin diisostearate 4 parts by weight Sorbitan sesquiolate 0.5 parts by weight C Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight Glyceryl triisooctate 5 parts by weight D. water 56.1 parts by weight Sulfated sodium alginate 0.1 part by weight Bacgacone essence 0.1 part by weight Elhibin 0.1 part by weight Kouki extract BG 0. 1 part by weight Placenta extract 0.1 part by weight Glycogen 0.1 part by weight Royal jelly 0.1 part by weight Ginseng essence 0.1 part by weight Ougon essence 0.1 part by weight Birch essence 0.1 part by weight ascorbic acid phosphoric acid Magnesium 0.1 weight Amount 0.1 parts by weight of arbutin

Example 12 According to the following formulation,
An anti-inflammatory cream, a skin external medicine, was prepared. That is, each of the components (a), (b), (c), and (d) are heated to 70 ° C., (a) and (b) are mixed, kneaded well, and the mixture is diluted by adding (c), and gradually added and emulsified. After stirring and cooling, a cream was obtained. A 70% maltose aqueous solution 5 parts by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methyl paraben 0.2 parts by weight Indomethacin 1 part by weight b Triglycerin diisostearate 4 parts by weight Sorbitan sesquiolate 0.5 parts by weight C Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight Glyceryl triisooctanoate 5 parts by weight D. water 57.1 parts by weight Sulfated sodium alginate 0.1 part by weight Bacgacone essence 0.1 parts by weight Elhibin 0.1 parts by weight Kouki extraction Material BG 0.1 part by weight Placenta extract 0.1 part by weight Glycogen 0.1 part by weight Royal jelly 0.1 part by weight Ginseng essence 0.1 part by weight Ougon essence 0.1 part by weight Birch essence 0.1 part by weight Part ascorbic acid Magnesium acid 0.1 parts by weight arbutin 0.1 part by weight

Example 13 According to the following formulation,
A steroid cream for external use on the skin was prepared. That is, each of the components (a), (b), (c), and (d) are heated to 70 ° C., (a) and (b) are mixed, kneaded well, and the mixture is diluted by adding (c), and gradually added and emulsified. After stirring and cooling, a cream was obtained. A 70% maltose aqueous solution 5 parts by weight glycerin 3 parts by weight 1,3-butanediol 5 parts by weight methyl paraben 0.2 parts by weight estradiol 1 part by weight b triglycerin diisostearate 4 parts by weight sorbitan sesquiolate 0.5 parts by weight c Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight Glyceryl triisooctanoate 5 parts by weight D. water 57.1 parts by weight Sulfated sodium alginate 0.1 part by weight Bacgacone essence 0.1 parts by weight Elhibin 0.1 parts by weight Kouki extraction Material BG 0.1 part by weight Placenta extract 0.1 part by weight Glycogen 0.1 part by weight Royal jelly 0.1 part by weight Ginseng essence 0.1 part by weight Ougon essence 0.1 part by weight Birch essence 0.1 part by weight Department Ascorbin Magnesium phosphate 0.1 part by weight arbutin 0.1 part by weight

Example 14 According to the following formulation,
An antifungal cream, a skin external medicine, was prepared. That is,
Heat each component of b, b, c and d to 70 ° C, mix a and b, knead well, dilute by adding c, add d slowly to this, emulsify and stir Cool to obtain a cream. A 70% maltose aqueous solution 5 parts by weight Glycerin 3 parts by weight 1,3-butanediol 5 parts by weight Methylparaben 0.2 parts by weight Bifonazole 1 part by weight b Triglycerin diisostearate 4 parts by weight Sorbitan sesquiolate 0.5 parts by weight C Light isoparaffin 10 parts by weight Liquid paraffin 10 parts by weight Glyceryl triisooctanoate 5 parts by weight D. water 57.1 parts by weight Sulfated sodium alginate 0.1 part by weight Bacgacone essence 0.1 parts by weight Elhibin 0.1 parts by weight Kouki extraction Material BG 0.1 part by weight Placenta extract 0.1 part by weight Glycogen 0.1 part by weight Royal jelly 0.1 part by weight Ginseng essence 0.1 part by weight Ougon essence 0.1 part by weight Birch essence 0.1 part by weight Part ascorbic acid Magnesium acid 0.1 parts by weight arbutin 0.1 part by weight

[0022]

According to the present invention, it is possible to provide a skin external composition such as a cosmetic, which has an excellent dulling effect and is effective against aging.

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Claims (7)

[Claims] 1. A composition for external use on the skin, comprising an elastase activity inhibitor and a melanin production inhibitor. 2. The composition for external use on skin according to claim 1, wherein the elastase activity inhibitor is an essence of soybean protein and / or kouki. 3. The method according to claim 1, wherein the melanin production inhibitor is one or more selected from arbutin, vitamin C, a derivative of vitamin C, royal jelly essence and soybean essence. External composition for skin. 4. The composition for external use on the skin according to any one of claims 1 to 3, which is a cosmetic. 5. It is for improving dullness,
The composition for external use on the skin according to any one of claims 1 to 4. 6. A cosmetic containing soybean protein and / or kouki essence and one or more selected from arbutin, vitamin C, vitamin C derivative, royal jelly essence and soybean essence. 7. It is for improving dullness,
The cosmetic according to claim 6.