JP2000142849A - Aerosol device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To always spray a powdery material including effective components by a specified quantity and improve its usability by equipping a constant quantity spray type valve in an aerosol device in which the powdery material is contained. SOLUTION: This aerosol device 1a is constituted of a close-ended cylindrical container body 26 filled with the contents including a powdery material A, a valve 3a, a spray button 4, and a tube 20 provided with a residence means 5. The constant quantity spray type valve 3a is equipped and the tube 20 in which a nearly spiral bent 21 is formed is fitted to the valve 3a. The powder A of the contents held therein can be sprayed by a specified quantity. When the spray button 4 is depressed, a tank 28 is deformed by the vapor pressure of the liquefied gas in the container body 26, led through a communication hole 33 and the contents in a constant volume chamber 31 are sprayed from a nozzle 18 through a hole 30, a communication hole 32, and a spraying passage 17.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an aerosol device. More specifically, the present invention relates to an aerosol device that can be suitably used as, for example, various pharmaceuticals, quasi-drugs, cosmetics, industrial products, and the like.

[0002]

2. Description of the Related Art Conventionally, as an aerosol device containing a powder (powder), there is an aerosol device for antiperspirant or an aerosol device for spraying a medicine to a locally affected part. As shown in FIG. 5, for example, such an aerosol device includes a cylindrical container body 50 having a bottom, a valve 53 caulked to a funnel-shaped opening 51 of the container body 50 via a gasket 52, Stem 54 projecting from
And a push button 56 for injecting the contents filled in the container body 50 through a dip tube 55 fitted to the valve 53 by reducing the pressure. Since the content is a composition comprising the powder 57, the oil-soluble component and the liquefied gas, the powder 57 is settled before use and is deposited on the bottom of the container body 50.

[0003]

Therefore, in such an aerosol device, the contents are usually shaken so as to be uniform before spraying. However, as shown in FIG.
Has a small diameter and internal pressure is applied inside, so the tube 5
The contents in 5 are not easily stirred. Therefore, the tube 5
It is difficult for the powder 57 to enter the inside 5. When the continuous injection is performed, the contents can be sufficiently injected except in the initial stage of the injection. However, when the intermittent injection is performed, FIGS.
As shown in the figure, the powder 57 that has been uniformly filled in the tube 55 after the previous injection also sinks down again,
Since the inside is mostly liquefied gas, there is a problem that a large amount of liquefied gas is sprayed in the early stage of the spraying than the powder 57 which is an effective component of the contents, and a predetermined amount of the effective component is not sprayed. In particular, an aerosol device using a valve with a small injection amount has a problem that a predetermined amount of powder cannot be injected.

On the other hand, it is conceivable to reduce the diameter of the tube to reduce the amount of liquefied gas in the tube. However, since the diameter of the tube is smaller, it is more difficult to stir the contents in the tube. The problem of jetting has not been solved.

[0005] In view of the circumstances described above, an object of the present invention is to provide an aerosol device which always sprays a predetermined amount of powder of an active ingredient and which is easy to use.

[0006]

The aerosol device according to the present invention is an aerosol device filled with contents including powder, wherein a valve mounted on the aerosol device is a fixed-quantity injection type valve. It is characterized by.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An aerosol device according to the present invention will be described below with reference to the accompanying drawings.

FIG. 1 is a partial sectional view showing a reference example of an aerosol device according to the present invention, FIG. 2 is a partial sectional view showing an embodiment of the present invention, and FIG. 3 is an enlarged view of the fixed injection valve in FIG. FIG. 4 is a partial sectional view showing another example of the tube.

As shown in FIG. 1, the aerosol device 1 comprises:
It is composed of a bottomed cylindrical container body 2 filled with contents including powder A, a valve 3, an injection button 4, and a tube 5, and the tube 5 has a retaining means B. If the valve is a fixed injection valve,
Preferably, the tube has retention means B.

The valve 3 is provided with a mounting cup 6
And a spray valve 7 supported by the mounting cup 6 and caulked via a gasket 10 to a curl portion 9 formed in a funnel-shaped opening 8 of the container body 2.

A communication hole 12 provided in the stem 11 of the valve 3 is sealed at a lower portion of the communication hole 12 by a stem rubber 14 fixed between the mounting cup 6 and the housing 13.

The stem 11 is made of, for example, metal or synthetic resin and has a smooth surface. The stem rubber 14 slides on the stem 11 when the stem 11 is pushed in the axial direction, facing the spring 15 housed in the housing 13, and slides on the stem 11 below the stem rubber 14. The communication hole 12 provided in the portion is pushed in, and the contents in the aerosol device 1
Through the conduction hole 16 of the stem 11.

The material of the stem rubber 14 includes, for example, natural rubber, synthetic rubber such as nitrile rubber, butyl rubber, chloroprene rubber, etc. Among them, nitrile rubber which can smoothly slide with the stem 11 is used. Acrylonitrile, especially 30% by weight
Nitrile rubbers containing above, for example, middle and high nitriles, high nitriles and extremely high nitriles are particularly preferred.

The mounting of the valve 3 is directly caulked to the container body 2, but this is not limited, and the valve 3 may be mounted via a shoulder which is mounted on the container body by double winding. Can also.

Injection button 4 fitted to the stem 11
Is an injection passage 17 communicating with the conduction hole 16 of the stem 11.
A nozzle 18 is fitted to the tip of the, so that the contents can be sprayed.

The upper end of the tube 5 is fitted to the housing 13 of the injection valve 7, and the lower end extends to the bottom of the container body 2. As a material of the tube 5, polyethylene, polypropylene, nylon, polyvinyl chloride, or the like can be used. The outer diameter of the tube 5 is 1.0 to 6.0 mm, preferably 1.0 to 6.0 mm.
5.0 mm. The inner diameter of the tube 5 is 0.5 to
It is 4.0 mm, and preferably 0.5 to 3.0 mm. The tube 5 is provided with a bent portion 19 serving as a staying means B, which is formed at an angle capable of staying the contents, and has a hiragana "" shape. This bent part 1
9, the powder A of the content can be retained in the bent portion 19 of the tube 5 even after the content is jetted, so that the predetermined amount of the powder A of the active ingredient is jetted at the next jet. Can be.

Although the retaining means B is formed as a bent portion having a substantially character shape, the present invention is not limited to this, as long as it retains the powder of the contents.

For example, in the embodiment shown in FIGS.
An aerosol device 1a is provided with a metering injection type valve 3a, and a tube 20 having a substantially spiral bent portion 21 is mounted on the metering valve 3a. In the present embodiment, the powder A of the content is retained in a larger amount than the bent portion 19 having the substantially character shape, and the powder A can be sprayed by a predetermined amount. Further, a predetermined amount of powder A can be sprayed as compared with a case where a normal straight tube before the tube 20 having the bent portion 21 is mounted.

The injection button 4 is connected to the stem 22 of the metering valve 3a, and the stem rubber 24 is pressed against the mounting cap 25 by a spring 23 provided below the stem 22 to keep the container body 26 hermetically sealed. It is.

On the outer periphery of the guide bush 27 to which the stem rubber 24 is fixed, for example, rubber, elastomer,
A tank 28 made of a flexible material such as a soft plastic is provided. The tank 28
Are fixed by the housing 29 and are parts that swing during injection. The tube 2 is provided on the lower surface of the housing 29.
0 is connected.

The contents filled in the container main body 26 enter the housing 29 via the tube 20 and enter the stem 2.
2 enters the inside of the guide bush 27 through the gap between the tank 28 and the stem 22 and the guide bush 27, and then passes through the hole 30 to form a fixed volume chamber 31 formed between the guide bush 27 and the tank 28. Is filled in.

The contents in the container body 26 enter the housing 29 through the tube 20 when the valve is operated, but since the lower portion of the stem 22 is completely sealed between the tank 28 and the guide bush 27, The contents are not introduced into the interior.

Since the internal pressure of the container main body 26 is higher than the external pressure (atmospheric pressure) of the container main body 26, when the injection button 4 is pressed downward, the injection passage 17 and the fixed amount chamber 31 are connected to the communication hole 32, When communicated via the guide bush 27, the tank 28 is deformed by the vapor pressure of the liquefied gas in the container main body 26 introduced through the communication hole 33,
The contents in the metering chamber 31 are jetted from the nozzle 18 through the hole 30, the communication hole 32 and the jet passage 17 in order.

Alternatively, instead of the bent portions 19 and 21, a tube 40 can be formed as shown in FIG. 4 to form a substantially N-shaped bent portion 41. By forming the substantially N-shaped bent portion 41, the powder A similar to the substantially letter-shaped bent portion 19 can be retained. Can be sprayed.

Further, the bent portion as the retaining means is formed integrally with the tube, but the present invention is not limited to this. A tube bent portion formed separately can be connected to the tube. Further, in order to maintain the shape of the bent portion, for example, a steel wire or a coil spring may be attached along the tube outer wall portion of the bent portion. Further, although the nozzle is fitted in the ejection passage of the ejection button, for example, a long nozzle may be fitted instead of the nozzle, or an extension tube with a nozzle may be fitted.

Examples of the contents filled in the container bodies 2 and 26 include, for example, an aerosol composition comprising a powder (powder), an oil-soluble component and a propellant.

Depending on the type of the powder, for example, astringents for pharmaceuticals, antifungal agents, local anesthetics,
It is used as a medicinal ingredient such as a bactericide, an external medicine, an active ingredient of an asthma drug or a quasi-drug, or an active ingredient of cosmetics. And a component used for coloring the aerosol composition or imparting hiding power.

Examples of the powder include aluminum chlorohydrate, tolnaphthate, lidocaine, chlorohexidine gluconate, magnesium oxide,
Zinc oxide, titanium oxide, boron nitride, light (precipitated) calcium carbonate, heavy magnesium carbonate, light magnesium carbonate, heavy calcium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjo, chromium oxide, silicic anhydride, silica Magnesium oxide, talc, kaolin, mica, titanium mica,
Bismuth oxychloride, zirconium oxide, chromium hydroxide, calamine, nylon powder, polyethylene powder, polystyrene powder, acrylic resin powder, for example, hybrid fine powder of inorganic pigment such as titanium oxide and organic polymer powder such as nylon 12, etc. These powders are used alone or in combination of two or more.

If the content of the powder in the aerosol composition is too large, there is a risk of clogging the hole of a valve or a button. If the content is too small, the content of the powder is caused by containing the powder. Since the effect tends to not be sufficiently exhibited, 3 to 40% by weight,
In particular, it is preferably from 5 to 30% by weight.

The oil-soluble component is, in addition to the component itself having a medicinal effect, a solvent for solubilizing the active component, an improvement in powder dispersibility in an aerosol composition, and a spreadability of powder at the time of injection. It is a component used for improvement.

Specific examples of the oil-soluble component include silicone oils such as chain dimethyl silicone oil (methyl polysiloxane) and dimethyl trimethyl silicone oil; liquid paraffin, isoparaffin hydrocarbons (for example, Isopar A manufactured by Exxon, Inc .; C, D, E, G, H, K, L, M), petrolatum, squalane (hexamethyltetracosane), α-olefin oligomer, squalene (hexamethyltetracosahexaene), etc. Hydrocarbons; synthetic oils such as isopropyl myristate, myristyl myristate, isopropyl palmitate, octyl dodecyl myristate, butyl stearate, hexyl laurate and the like; olive oil, almond oil, jojoba oil, peanut oil, castor oil , Palm oil Vegetable oils such as palm oil, safflower oil, sunflower oil, cottonseed oil, avocado oil, camellia oil, corn oil, wheat germ oil, rice bran oil, cacao oil, sesame oil, evening primrose oil, safflower oil, sasanqua oil, soybean oil, and rapeseed oil Natural oils such as lanolin and lanolin derivatives, turtle oil, mink oil, beeswax, squalene, pristane, egg yolk oil, etc .; oil-soluble surfactants such as polyglycerin fatty acid ester, polyoxyethylene (5 mol) hydrogenated castor oil (Nonionic surfactants having an HLB of 2 to 7) and the like, and these oil-soluble components are used alone or in combination of two or more. Among these oil-soluble components, silicone oil, hydrocarbons, natural oils and the like are preferably used because they have a polishing effect, an improvement in sliding properties, and an effect of replenishing oil to the skin. Synthetic oils such as esters and the like are particularly effective in improving powder dispersibility and spreadability in addition to these effects, and thus can be particularly preferably used in the present invention.

When the content of the oil-soluble component in the aerosol composition is too large, the feeling of dryness of the aerosol composition is reduced, the feeling of use becomes extremely poor, and when the content is too small, Is preferably 0.1 to 10% by weight, more preferably 0.5 to 8% by weight, since the adhesiveness of the aerosol composition at the time of spraying is low and the composition tends to peel off on the coated surface.

As the propellant, dimethyl ether,
Fluorocarbons, aliphatic hydrocarbon compounds having 3 to 5 carbon atoms (liquefied petroleum gas, LPG), for example, propane, i
-Butane, n-butane, i-pentane and n-pentane, and these can be used alone or in combination of two or more. Such a propellant is preferably adjusted so that the pressure at 35 ° C. is 0.2 to 0.8 MPa.

If the content of the propellant in the aerosol composition is too large, the content of other components becomes relatively small, and the aerosol composition decreases rapidly, which is uneconomical. If the amount is too small, the aerosol composition tends to be insufficiently sprayed, so that 50 to 95% by weight, especially 60 to 95% by weight.
Preferably it is 90% by weight.

The aerosol composition may contain, for example, humectants (polyhydric alcohols such as glycerin, propylene glycol, and sorbitol, pyrrolidone carboxylate, lactate, sodium hyaluronate, etc.) depending on the use.
Hair setting agents (polyvinylpyrrolidone, methoxyethylene maleic anhydride copolymer, amphoteric methacrylate copolymer, etc.), ultraviolet absorbers (benzophenone derivatives, paraaminobenzoic acid derivatives, methoxycinnamate, salicylic acid derivatives, etc.), whitening Agents (such as albumin, kojic acid, vitamin C and derivatives thereof), agents for hair growth (such as assembly extract, cepharanthin, γ-oryzanol, capsicum tincture, ginger tincture, cantaristin tincture, nicotinic acid benzyl ester, vitamins (A, B1, B2, B6, E and derivatives thereof), pantothenic acid, biotin, cystine, cysteine, methionine, serine, leucine, tryptophan, amino acid extract, estradiol, ethinylestradiol, placenta extract, ara Knights Inn etc.), anti-inflammatory agents (beta-
Glycyrrhetinic acid, glycyrrhetinic acid derivatives, azulene, ε-aminocaproic acid, etc.), astringents (allantoin hydroxyaluminum, zinc sulfate, zinc oxide, aluminum chloride, aluminum sulfate, tannic acid, citric acid, etc.), fresheners (menthol, camphor) ), Antihistamines (diphenhydramine hydrochloride, chlorferamine maleate, glycyrrhizinate derivatives, etc.), acne drugs (estrone, estradiol, ethinyl estradiol, resorcinol, salicylic acid, etc.), fungicides (benzalkonium chloride, benzethonium chloride, halocarban) , Zinc pyrithione, chlorhexidine, 2,
4,4-trichloro-2-hydroxyphenol, isopropylmethylphenol, etc., antiperspirants (chlorohydroxyaluminum, aluminum chloride, allantoinchlorohydroxyaluminum, zinc oxide, aluminum potassium sulfate, zinc paraphenolsulfonate, etc.), anti-inflammatory An active ingredient such as an analgesic (methyl salicylate, indomethacin, ketoprofen, ibuprofen piconol, piroxicam, ferpinac, glycyrrhetinic acid, benzatac, etc.), a fragrance and the like may be added.

The amount of the active ingredient, solvent and the like added is preferably 10% by weight or less, more preferably 8% by weight or less in the aerosol composition.

Further, a thickener may be added to suppress the sedimentation of the active ingredient and disperse the active ingredient in the composition.

Examples of the thickener include bentonite, laponite, finely divided silicon oxide, colloidal alumina, cellulose powder (methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose), carboxymethyl starch, methyl starch, Propylene glycol alginate, alginate, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxyvinyl polymer, sodium polyacrylate, guar gum, locust bingham, quince seed, carrageenan, galactan, arabic gum, tragacanth gum, pectin, mannan, xanthan gum, Dextran, succino glucan, curdlan Hyaluronic acid, gelatin, casein, albumin, such as collagen and the like. In the present invention, the thickener is dissolved in the oil-soluble component and the propellant,
It is not particularly limited as long as it is dispersed.

Next, the aerosol device of the present invention will be further described by way of examples, but the present invention is not limited to only these examples.

REFERENCE EXAMPLE 1 A metal pressure-resistant container (full injection volume: 200 ml) was charged with 90 g of an aerosol composition by mixing the following components, and a valve and a button shown in FIG. 1 were attached to obtain a drug for athlete's foot.

Ingredient Incorporation amount (wt%) Tolnaftate 0.3 Zinc oxide 2.0 Talc 9.7 Isopropyl myristate 3.0 LPG 85.0 (Total) (100.0)

Example 1 A metal pressure-resistant container (full injection volume: 200 ml) was filled with 100 g of an aerosol composition by mixing the following components, and a valve and a button shown in FIG. 2 were attached to obtain an antiperspirant.

Ingredients Compounding amount (wt%) Aluminum chlorohydrate 6.0 Talc 9.8 Zinc oxide 1.5 Hydroxymethylcellulose 0.2 Isopropyl myristate 3.0 Dimethylpolysiloxane 2.0 Sorbitanic acid aliphatic ester 1 2.0 perfume appropriate amount dimethyl ether 5.0 LPG 70.0 (total) (100.0)

Reference Example 2 A metal pressure-resistant container (full injection volume: 200 ml) was filled with 100 g of the aerosol composition by mixing the following components, and the valve and button of FIG. 1 equipped with a dip tube shown in FIG. I got the powder foundation.

Component Blended amount (wt%) Benkara 0.9 Yellow iron oxide 0.5 Black iron oxide 0.1 Boron nitride 7.0 Liquid paraffin 1.0 Isopropyl myristate 0.5 Perfume Appropriate amount LPG 90.0 (Total) (100.0)

Example 2 A metal pressure-resistant container (full injection volume: 200 ml) was charged with 90 g of an aerosol composition by mixing the following components, and a valve and a button shown in FIG. 2 were attached to obtain a wound medicine.

Ingredient Compounding amount (wt%) Zinc oxide 0.46 Talc 2.4 Acrinol 0.01 Lidocaine 0.02 Dipotassium glycyrrhizinate 0.01 Isopropyl myristate 7.0 LPG 90.0 (Total) (100) .0)

Examples 1 and 2 and Reference Examples 1 and 2
, An injection test was performed using the obtained aerosol device. As a result, it was found that a predetermined amount of the active ingredient can always be injected.

[0049]

As described above, according to the present invention,
Since the valve of the aerosol device filled with the contents including the powder is a fixed-quantity injection type valve, the powder of the active ingredient is always injected in a predetermined amount, thereby improving the usability.

[Brief description of the drawings]

FIG. 1 is a partial cross-sectional view showing a reference example of an aerosol device according to the present invention.

FIG. 2 is a partial sectional view showing an embodiment of the present invention.

FIG. 3 is an enlarged view of a fixed injection type valve in FIG. 2;

FIG. 4 is a partial sectional view showing another example of the tube.

FIG. 5 is a partial sectional view showing a conventional aerosol device.

FIG. 6 is a partial sectional view showing an example of use of the aerosol device in FIG.

FIG. 7 is a partial sectional view showing an example of use of the aerosol device in FIG.

[Explanation of symbols]

 1a Aerosol device 3a Valve 4 Injection button 20 Tube 21 Bend 22 Stem 26 Container body A Powder

Claims (5)

[Claims] 1. An aerosol device filled with contents including a powder, wherein a valve mounted on the aerosol device is a fixed injection type valve. 2. The fixed injection type valve has a structure for sealing a lower portion of a stem when the valve is operated.
An aerosol device as described. 3. The aerosol device according to claim 1, wherein a tube is attached to said fixed injection type valve. 4. The fixed injection type valve is configured such that a stem rubber is pressed against a mounting cap by a spring provided below a stem, and a tank is provided between a guide bush that fixes the stem rubber in the housing and the housing. The aerosol device according to claim 2 or 3, which is fixed. 5. The content of the powder is 3 to 40% by weight.
The aerosol device according to claim 1, 2, 3, or 4, wherein