JP2000080001A - Insect pest-controlling agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an insect pest-controlling agent that is useful for controlling insect pests, particularly for controlling fleas by using an insect growth regulator and a specific caranediol as active ingredients. SOLUTION: This insect pest-controlling agent includes, as active ingredients, (A) an insect growth regulator, preferably selected from pyriproxyfen, methoprene, fenoxycarb and the like and (B) a carane-3,4-diol, for example, 1S,3S,4S,6R-carane-3,4-diol. In a preferred embodiment, the weight ratio of the insect growth regulator to the carane-3,4-diol is 1/3-1/5,000, more preferably 1/10-1/1,000. This controlling agent can inhibit eggs of flea from hatching and is useful for controlling flea.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a pesticidal agent, particularly to a pesticidal agent suitable for controlling fleas by inhibiting hatching of flea eggs.

[0002]

2. Description of the Related Art Karan-3,4-diol is disclosed in
It is known as an active ingredient of a pest repellent in JP-A-4901.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a pesticidal agent suitable for controlling fleas.

[0004]

According to the present invention, an insect growth controlling substance is used for controlling pests, especially fleas, by using an insect growth controlling substance in combination with karan-3,4-diol. Compared to the case of using alone, it is possible to make the insect growth controlling substance act more effectively, and the present invention provides a new type of carane-3,4-diol known as an active ingredient of a repellent. It is intended to provide applications.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The insect growth controlling substances used in the present invention include juvenile hormone-like substances such as pyriproxyfen, mesoprene and phenoxycarb, chlorfluazuron, hexaflumuron, lufenuron, teflubenzuron, flufenoc. SULON, N-2,6-difluorobenzoyl-N '-[2-fluoro-4- (1,
1,2,3,3,3-hexafluoropropoxy) phenyl] urea, N-2,6-difluorobenzoyl-
Chitin synthesis inhibiting substances such as N ′-[2-fluoro-4- (1,1,2,2-tetrafluoroethoxy) phenyl] urea and the like.

[0006] In the present invention, the insect growth regulator and curan-
The use ratio with 3,4-diol is usually 1: 3 by weight.
１ ： 1: 5000, preferably 1: 10-1: 1000. Curan-3 used in the present invention,
There are various stereoisomers of 4-diol, and any active isomer can be used in the present invention.
S, 3S, 4S, 6R-calane-3,4-diol, 1
It is more effective to use R, 3R, 4R, 6S-calane-3,4-diol and an isomer mixture having an increased content thereof.

[0007] The pest control agent of the present invention usually contains, in addition to the active ingredients of the insect growth controlling substance and carane-3,4-diol, a suitable carrier, and if necessary, a surfactant and other auxiliary agents for preparation. It contains various forms such as lotions, spot-on preparations, pour-on preparations, shampoos, powders, aerosol preparations, collars, ear tags and the like.

[0008] Carriers used in the formulation include solid carriers such as kaolin clay, diatomaceous earth, bentonite, acid clay, sericite, quartz, talc, silica, ceramics, water, alcohols (methanol, ethanol, etc.),
Ketones (acetone, methyl ethyl ketone, etc.), hydrocarbons (toluene, xylene, kerosene, hexane, paraffin, petroleum benzene, etc.), halogenated hydrocarbons (dichloroethane, trichloroethane, etc.), esters (ethyl acetate, butyl acetate, etc.) And liquid carriers such as ethers (diethyl ether, dioxane, etc.). When the pest control agent of the present invention is an aerosol preparation, nitrogen, carbon dioxide, dimethyl ether, LP
A gas carrier such as G or chlorofluorocarbon is contained as a propellant.

When the pest control agent of the present invention contains a surfactant, specific examples of the surfactant used include alkyl sulfates, alkyl aryl sulfonates, alkyl aryl ethers, polyoxyethylenated alkyl aryl ethers , Polyoxyethylene glycol ethers, polyhydric alcohol esters, sugar alcohol derivatives and the like.

[0010] The pest control agent of the present invention may further include, as other pharmaceutical auxiliaries, casein, gelatin, starch, gum arabic, alginic acid, cellulose derivatives, lignin derivatives,
Fixing or dispersing agents such as synthetic water-soluble polymers (polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acids, etc.), PAP (acidic isopropyl phosphate), BHT, BH
A, a stabilizer such as vegetable oil, mineral oil, fatty acid, fatty acid ester and the like may be contained.

[0011] When the pesticidal composition of the present invention is formulated into a collar or ear tag, a resin such as vinyl chloride or polyurethane is usually used as the base material. In the substrate,
If necessary, a plasticizer such as phthalic acid ester (dimethyl phthalate, dioctyl phthalate, etc.), adipic acid ester, stearic acid and the like are contained. When manufacturing a collar or ear tag, for example, an insect growth controlling substance and kalan-3,4-diol are kneaded in the base material, and injection molding, extrusion molding,
After molding by press molding or the like, further molding or cutting is performed as appropriate.

Further, generally known insecticides can be appropriately added to the pest control agent of the present invention. For example,
Pyrethroid compounds such as permethrin, phenothrin and cyphenothrin, organic phosphorus compounds such as diazinon, dichlorvos and tetrachlorovinphos, carbamate compounds such as propoxur, carbaryl and methoxadiazon; (E) -N ¹ -[(6-chloro 3-pyridyl) methyl] -N ² - cyano -N ¹ - methyl acetamidine (common name: acetamiprid), N - [(6-chloro -
3-pyridinyl) methyl] -N-ethyl-N'-methyl-2-nitro-1,1-ethylidenediamine (generic name:
Nitenpyran), 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine, 1-
Chloronicotyl compounds such as (tetrahydrofuran-2-yl) methyl-3-methyl-2-nitroguanidine;
And phenylpyrazole compounds.

[0013] The insect pest control agent of the present invention is a cat flea (Ctenocephal
ides felis), dog flea (Ctenocephalides canis), keops flea (Xenopsylla cheopis), human flea (Pulex
irritans) is particularly effective in controlling fleas,
Bovine lice (Haematopinus eurysternus), sheep lice
(Damalinia ovis), louse, Haemaphysalis longicornis (Haema
phyxalis longicornis) and Bovine ticks (Boophilus micr)
oplus) is also effective in controlling ticks. In addition, housefly (Musca domestica), housefly (Musca hervei), housefly (Musca bezzii), flies (Haematonia ir
ritans), Simulium iwatens, Culicoides oxystoma, and Tabanus chrysuru
s), Culex pipiens, Aedes albopictus (Aede
s albopictus), Drosophila, Chironomidae, and other dipteran pests, German cockroaches (Blattella germanica), black cockroaches (Periplaneta fuliginosa), cockroaches (P
It is also effective for controlling insects of the order Aphid, such as eriplaneta americana).

When the pesticidal composition of the present invention is a lotion, spot-on preparation, pour-on preparation, shampoo, etc., it is usually applied directly to animals. In the case of powders, aerosol preparations and the like, they may be applied directly to animals, or may be applied to the place where animals live and their surroundings, places where pests live, and the like.
Collars and ear tags are usually used by attaching them to animals. In the present invention in which an insect growth controlling substance and carane-3,4-diol are used in combination to control pests, the use of the pest control agent of the present invention containing both is convenient.
It is not always necessary to prepare and use the insect pest control agent of the present invention containing both in advance, and each preparation of the insect growth regulator and carane-3,4-diol may be used in combination. .

[0015]

The present invention will be described below in more detail with reference to examples. First, preparation examples of the pest control agent of the present invention will be described. Formulation Example 1 0.05 parts by weight of pyriproxyfen and 1S, 3S, 4S, 6
5 parts by weight of R-curane-3,4-diol is dissolved in ethanol to make the whole 35 parts by weight, and the solution is placed in an aerosol container. Next, a valve is attached to the aerosol container, and 65 parts by weight of LPG (propellant) is filled under pressure through the valve portion to obtain an aerosol formulation.

Formulation Example 2 5 parts by weight of pyriproxyfen, 45 parts by weight of permethrin, and 50 parts by weight of 1S, 3S, 4S, 6R-carane-3,4-diol are mixed to obtain a spot-on preparation.

Formulation Example 3 3 parts by weight of mesoprene, 47 parts by weight of 1S, 3S, 4S, 6R-calane-3,4-diol and 50 parts by weight of dipropylene glycol monomethyl ether are mixed to obtain a spot-on preparation.

Formulation Example 4 Artificial leather base material (Clarino 6038-0018, length 358 mm, width 15
mm, thickness 2.8mm), 0.01g of pyriproxyfen,
2.0 g of 1S, 3S, 4S, 6R-carane-3,4-diol is dropped and impregnated. A buckle is attached to one end of the impregnated base material to obtain a collar preparation.

Next, test examples show that the pest control method of the present invention is effective. Test Example 1 A single or mixture of pyriproxyfen and 1S, 3S, 4S, 6R-carane-3,4-diol was diluted with acetone, dropped on a filter paper having a diameter of 3.8 cm, and air-dried. Approximately 20 cat flea eggs (within 24 hours after childbirth) were placed on the obtained filter paper. Put the filter paper in a plastic petri dish,
After storing at a temperature of 26 ° C. and a humidity of 95%, the hatching of the fleas was observed 5 days later. Table 1 shows the results of the triplicate test. The hatching inhibition rate (%) in the table is the following formula when the flea egg hatching rate (92.4%) in the untreated section where no drug treatment was performed was C, and the flea egg hatch rate in each of the drug treated sections was T.

[0020]

[Equation 1] Hatching inhibition rate (%) = (CT) ÷ C × 100

The corrected hatching inhibition rate (%) calculated by In the table, PY in the drug column represents pyriproxyfen, CA
Represents 1S, 3S, 4S, 6R-carane-3,4-diol. In the table, the unit of the treatment dose is mg / m ² .

[0022]

【table 1】

As shown in the above table, the hatching inhibitory activity of pyriproxyfen (insect growth regulator) on flea eggs is greatly enhanced by the addition of carane-3,4-diol.

[0024]

The pest control agent of the present invention is suitable for controlling pests, particularly for controlling fleas.

Claims (6)

[Claims] A pest control agent comprising an insect growth controlling substance and carane-3,4-diol as active ingredients. 2. The pesticidal composition according to claim 1, wherein the weight ratio of the insect growth controlling substance and carane-3,4-diol is in the range of 1: 3 to 1: 5000. 3. The insect growth controlling substance is pyriproxyfen, mesoprene, phenoxycarb, chlorfluazuron, hexaflumuron, lufenuron, teflubenzuron, flufenoxuron, N-2,6-difluorobenzoyl-N ′-[ 2-fluoro-4- (1,1,2,
3,3,3-Hexafluoropropoxy) phenyl] urea and N-2,6-difluorobenzoyl-N'-
The pesticidal composition according to claim 1 or 2, which is at least one member selected from the group consisting of [2-fluoro-4- (1,1,2,2-tetrafluoroethoxy) phenyl] urea. 4. The pesticidal composition according to claim 1, wherein the insect growth controlling substance is pyriproxyfen. 5. A method for controlling insect pests, which comprises using an insect growth regulator and carane-3,4-diol in combination. 6. A method for inhibiting hatching of flea eggs, which comprises using an insect growth regulator and carane-3,4-diol in combination.